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Gene: Thop1 (thimet oligopeptidase 1) Mus musculus
Symbol: Thop1
Name: thimet oligopeptidase 1
Description: Exhibits metalloendopeptidase activity. Involved in intracellular signal transduction and peptide metabolic process. Predicted to localize to the mitochondrial intermembrane space. Is expressed in head mesenchyme and vertebral axis musculature. Orthologous to human THOP1 (thimet oligopeptidase 1); PARTICIPATES IN renin-angiotensin cascade pathway; sleeping sickness pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dibromophenyl 2,4,5-tribromophenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI131655; AI327041; endopeptidase 24.15; EP24.15; thimet oligopeptidase
Homo sapiens (human) : THOP1 (thimet oligopeptidase 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Thop1 (thimet oligopeptidase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Thop1 (thimet oligopeptidase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : THOP1 (thimet oligopeptidase 1)
Canis lupus familiaris (dog) : THOP1 (thimet oligopeptidase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Thop1 (thimet oligopeptidase 1)
Sus scrofa (pig) : THOP1 (thimet oligopeptidase 1)
Chlorocebus sabaeus (African green monkey) : THOP1 (thimet oligopeptidase 1)
Heterocephalus glaber (naked mole-rat) : Thop1 (thimet oligopeptidase 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1081,070,035 - 81,082,559 (+)EnsemblGRCm38mm10GRCm38
GRCm381081,070,083 - 81,082,360 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371080,532,828 - 80,545,105 (+)NCBIGRCm37mm9NCBIm37
MGSCv361080,473,279 - 80,485,687 (+)NCBImm8
Celera1082,090,182 - 82,102,459 (+)NCBICelera
Cytogenetic Map10 C1NCBI
cM Map1039.72NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Cell Lines
Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Thop1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68461
Created: 2001-07-11
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.