lidocaine - Ontology Report - Rat Genome Database

lidocaine - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	lidocaine	go back to main search page
Accession:	CHEBI:6456	browse the term
Definition:	The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
Synonyms:	exact_synonym:	N-(2,6-dimethylphenyl)-N(2),N(2)-diethylglycinamide
	related_synonym:	2-(Diethylamino)-2',6'-acetoxylidide; 2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide; Formula=C14H22N2O; InChI=1S/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,5-6,10H2,1-4H3,(H,15,17); InChIKey=NNJVILVZKWQKPM-UHFFFAOYSA-N; Lidoderm; SMILES=CCN(CC)CC(=O)Nc1c(C)cccc1C; alpha-diethylamino-2,6-dimethylacetanilide
	xref:	CAS:137-58-6; DrugBank:DB00281; Drug_Central:1579; HMDB:HMDB0014426; KEGG:C07073; KEGG:D00358; LINCS:LSM-3165
	xref_mesh:	MESH:D008012
	xref:	PMID:11106996; PMID:11120381; PMID:11431418; PMID:11692349; PMID:15056998; PMID:16668583; PMID:17214917; PMID:18940244; Patent:GB706409; Patent:GB758224; Patent:US2441498; Reaxys:2215784; VSDB:1903; Wikipedia:Lidocaine

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Genes (647)

lidocaine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 1

increases expression

Lidocaine results in increased expression of ABCA1 mRNA

NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:67,681,297...67,801,170

G

ATP binding cassette subfamily A member 8

decreases expression

Lidocaine results in decreased expression of ABCA8 mRNA

NCBI chr10:95,416,984...95,490,647
Ensembl chr10:94,917,520...94,990,988

G

ATP binding cassette subfamily B member 4

increases expression

Lidocaine results in increased expression of ABCB4 mRNA

NCBI chr 4:26,106,895...26,164,440
Ensembl chr 4:25,151,953...25,209,202

G

actinin alpha 3

increases expression

Lidocaine results in increased expression of ACTN3 mRNA

NCBI chr 1:211,588,473...211,604,401
Ensembl chr 1:202,159,082...202,175,012

G

ADAM metallopeptidase with thrombospondin type 1 motif, 13

increases expression

Lidocaine results in increased expression of ADAMTS13 mRNA

NCBI chr 3:30,697,354...30,736,539
Ensembl chr 3:10,300,028...10,346,687

G

ADAM metallopeptidase with thrombospondin type 1 motif, 15

decreases expression

Lidocaine results in decreased expression of ADAMTS15 mRNA

NCBI chr 8:37,566,064...37,589,446
Ensembl chr 8:29,307,865...29,331,249

G

adhesion G protein-coupled receptor A2

decreases expression

Lidocaine results in decreased expression of ADGRA2 mRNA

NCBI chr16:71,635,814...71,674,275
Ensembl chr16:64,933,315...64,971,483

G

1-acylglycerol-3-phosphate O-acyltransferase 2

increases expression

Lidocaine results in increased expression of AGPAT2 mRNA

NCBI chr 3:29,814,924...29,826,569
Ensembl chr 3:9,416,843...9,428,371

G

A-kinase anchoring protein 5

decreases expression

Lidocaine results in decreased expression of AKAP5 mRNA

NCBI chr 6:100,787,169...100,796,712
Ensembl chr 6:95,051,537...95,061,578

G

AKT1 substrate 1

multiple interactions

bafilomycin A1 inhibits the reaction [Lidocaine results in decreased expression of [MTOR protein binds to RPTOR protein binds to MLST8 protein binds to PRAS40 protein binds to DEPTOR protein]]; dorsomorphin inhibits the reaction [Lidocaine results in decreased expression of [MTOR protein binds to RPTOR protein binds to MLST8 protein binds to PRAS40 protein binds to DEPTOR protein]]; Lidocaine results in decreased expression of [MTOR protein binds to RPTOR protein binds to MLST8 protein binds to PRAS40 protein binds to DEPTOR protein]; MK-8722 promotes the reaction [Lidocaine results in decreased expression of [MTOR protein binds to RPTOR protein binds to MLST8 protein binds to PRAS40 protein binds to DEPTOR protein]]

NCBI chr 1:104,469,823...104,476,168
Ensembl chr 1:95,332,898...95,339,677

G

aldehyde dehydrogenase 3 family, member B1

increases expression

Lidocaine results in increased expression of ALDH3B1 mRNA

NCBI chr 1:210,574,545...210,605,188
Ensembl chr 1:201,145,309...201,163,921

G

arachidonate 12-lipoxygenase, 12S type

increases expression

Lidocaine results in increased expression of ALOX12 mRNA

NCBI chr10:55,456,923...55,469,239
Ensembl chr10:54,958,271...54,970,542

G

alpha-kinase 1

increases expression

Lidocaine results in increased expression of ALPK1 mRNA

NCBI chr 2:218,801,425...218,924,013
Ensembl chr 2:216,128,825...216,247,157

G

amidohydrolase domain containing 2

increases expression

Lidocaine results in increased expression of AMDHD2 mRNA

NCBI chr10:13,692,136...13,700,632
Ensembl chr10:13,187,578...13,196,095

G

amelogenin, X-linked

increases expression

Lidocaine results in increased expression of AMELX mRNA

NCBI chr X:28,648,803...28,660,099
Ensembl chr X:25,076,362...25,087,660

G

adenosine monophosphate deaminase 1

increases expression

Lidocaine results in increased expression of AMPD1 mRNA

NCBI chr 2:193,287,219...193,308,446
Ensembl chr 2:190,598,700...190,619,938

G

angiopoietin 2

decreases expression

Lidocaine results in decreased expression of ANGPT2 mRNA

NCBI chr16:77,790,760...77,841,241
Ensembl chr16:71,088,364...71,138,804

G

angiopoietin 4

increases expression

Lidocaine results in increased expression of ANGPT4 mRNA

NCBI chr 3:160,880,539...160,913,923
Ensembl chr 3:140,420,389...140,453,583

G

angiopoietin-like 2

increases expression

Lidocaine results in increased expression of ANGPTL2 mRNA

NCBI chr 3:36,914,876...36,944,715
Ensembl chr 3:16,517,420...16,548,178

G

ankyrin repeat domain 33B

increases expression

Lidocaine results in increased expression of ANKRD33B mRNA

NCBI chr 2:82,277,604...82,359,420
Ensembl chr 2:82,283,108...82,358,872

G

acidic nuclear phosphoprotein 32 family member A

increases expression

Lidocaine results in increased expression of ANP32A mRNA

NCBI chr 8:71,724,578...71,760,922
Ensembl chr 8:62,827,456...62,865,443

G

annexin A6

increases expression

Lidocaine results in increased expression of ANXA6 mRNA; Lidocaine results in increased expression of ANXA6 protein

NCBI chr10:39,602,106...39,657,183
Ensembl chr10:39,097,109...39,156,433

G

amine oxidase, copper containing 3

decreases expression

Lidocaine results in decreased expression of AOC3 mRNA

NCBI chr10:86,773,018...86,780,961

G

apolipoprotein B mRNA editing enzyme catalytic subunit 1

increases expression

Lidocaine results in increased expression of APOBEC1 mRNA

NCBI chr 4:157,472,879...157,500,496
Ensembl chr 4:155,800,887...155,827,390

G

apolipoprotein L domain containing 1

increases expression

Lidocaine results in increased expression of APOLD1 mRNA

NCBI chr 4:169,499,728...169,557,075
Ensembl chr 4:167,818,271...167,825,706

G

aquaporin 4

decreases expression

Lidocaine results in decreased expression of AQP4 mRNA

NCBI chr18:6,782,389...6,799,034
Ensembl chr18:6,507,903...6,524,856

G

Rho GTPase activating protein 11A

increases expression

Lidocaine results in increased expression of ARHGAP11A mRNA

NCBI chr 3:121,045,187...121,071,985
Ensembl chr 3:100,590,865...100,607,559

G

Rho GTPase activating protein 30

decreases expression

Lidocaine results in decreased expression of ARHGAP30 mRNA

NCBI chr13:86,354,448...86,376,552
Ensembl chr13:83,822,283...83,854,885

G

Rho GTPase activating protein 45

increases expression

Lidocaine results in increased expression of ARHGAP45 mRNA

NCBI chr 7:10,325,515...10,340,955
Ensembl chr 7:9,674,897...9,690,268

G

Rho guanine nucleotide exchange factor 3

decreases expression

Lidocaine results in decreased expression of ARHGEF3 mRNA

NCBI chr16:2,308,311...2,588,634
Ensembl chr16:2,300,138...2,581,945

G

ARF like GTPase 11

increases expression

Lidocaine results in increased expression of ARL11 mRNA

NCBI chr15:39,659,404...39,661,651
Ensembl chr15:35,480,018...35,496,596

G

asparaginase

increases expression

Lidocaine results in increased expression of ASPG mRNA

NCBI chr 6:136,997,832...137,017,417
Ensembl chr 6:131,176,874...131,196,268

G

assembly factor for spindle microtubules

increases expression

Lidocaine results in increased expression of ASPM mRNA

NCBI chr13:53,625,584...53,674,489
Ensembl chr13:51,074,849...51,123,755

G

asporin

decreases expression

Lidocaine results in decreased expression of ASPN mRNA

NCBI chr17:15,286,338...15,310,567
Ensembl chr17:15,080,639...15,104,041

G

ATPase family, AAA domain containing 2

increases expression

Lidocaine results in increased expression of ATAD2 mRNA

NCBI chr 7:91,523,626...91,566,238
Ensembl chr 7:89,634,123...89,676,738

G

ATPase family, AAA domain containing 5

increases expression

Lidocaine results in increased expression of ATAD5 mRNA

NCBI chr10:65,568,569...65,616,379
Ensembl chr10:65,070,689...65,117,845

G

ATPase secretory pathway Ca2+ transporting 1

increases expression

Lidocaine results in increased expression of ATP2C1 mRNA

NCBI chr 8:114,913,551...115,034,706
Ensembl chr 8:106,034,636...106,156,006

G

ATPase H+ transporting V0 subunit D2

increases expression

Lidocaine results in increased expression of ATP6V0D2 mRNA

NCBI chr 5:38,133,151...38,182,245
Ensembl chr 5:33,336,264...33,385,354

G

ATPase phospholipid transporting 8B4 (putative)

increases expression

Lidocaine results in increased expression of ATP8B4 mRNA

NCBI chr 3:134,008,367...134,212,394
Ensembl chr 3:113,556,192...113,757,225

G

aurora kinase A and ninein interacting protein

increases expression

Lidocaine results in increased expression of AUNIP mRNA

NCBI chr 5:152,006,021...152,018,614
Ensembl chr 5:146,722,337...146,736,501

G

bile acid CoA:amino acid N-acyltransferase

increases expression

Lidocaine results in increased expression of BAAT mRNA

NCBI chr 5:68,647,166...68,656,137
Ensembl chr 5:63,850,705...63,860,685

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

SIRT1 protein inhibits the reaction [Lidocaine results in increased expression of BAX protein]

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression
multiple interactions

Lidocaine results in decreased expression of BCL2 protein
SIRT1 protein inhibits the reaction [Lidocaine results in decreased expression of BCL2 protein]

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 2

decreases expression

Lidocaine results in decreased expression of BCL2L2 mRNA

NCBI chr15:32,326,686...32,337,834
Ensembl chr15:28,356,807...28,361,624

G

bestrophin 2

increases expression

Lidocaine results in increased expression of BEST2 mRNA

NCBI chr19:40,047,191...40,053,216
Ensembl chr19:23,141,602...23,148,339

G

baculoviral IAP repeat-containing 5

increases expression

Lidocaine results in increased expression of BIRC5 mRNA

NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,073,408...103,081,380

G

BLK proto-oncogene, Src family tyrosine kinase

increases expression

Lidocaine results in increased expression of BLK mRNA

NCBI chr15:41,802,701...41,841,004
Ensembl chr15:37,627,039...37,665,031

G

B-cell linker

increases expression

Lidocaine results in increased expression of BLNK mRNA

NCBI chr 1:249,703,064...249,770,533
Ensembl chr 1:239,753,648...239,821,113

G

biliverdin reductase B

decreases expression

Lidocaine results in decreased expression of BLVRB protein

NCBI chr 1:91,866,258...91,883,921
Ensembl chr 1:82,738,695...82,770,375

G

Bcl2 modifying factor

increases expression

Lidocaine results in increased expression of BMF mRNA

NCBI chr 3:125,953,466...125,974,087
Ensembl chr 3:105,499,538...105,520,145

G

BPI fold containing family A, member 5

decreases expression

Lidocaine results in decreased expression of BPIFA5 mRNA

NCBI chr 3:163,106,258...163,113,039
Ensembl chr 3:142,646,103...142,652,883

G

BPI fold containing family B, member 2

decreases expression

Lidocaine results in decreased expression of BPIFB2 mRNA

NCBI chr 3:162,818,223...162,837,219
Ensembl chr 3:142,358,051...142,377,044

G

bassoon (presynaptic cytomatrix protein)

decreases expression

Lidocaine results in decreased expression of BSN mRNA

NCBI chr 8:117,663,447...117,754,412
Ensembl chr 8:108,788,542...108,875,819

G

betacellulin

increases expression

Lidocaine results in increased expression of BTC mRNA

NCBI chr14:16,992,668...17,031,178
Ensembl chr14:16,707,982...16,747,049

G

butyrophilin-like 5

increases expression

Lidocaine results in increased expression of BTNL5 mRNA

NCBI chr20:4,348,162...4,378,309
Ensembl chr20:4,365,793...4,376,385

G

BUB1 mitotic checkpoint serine/threonine kinase

increases expression

Lidocaine results in increased expression of BUB1 mRNA

NCBI chr 3:135,473,525...135,504,921
Ensembl chr 3:115,020,254...115,051,650

G

BUB1 mitotic checkpoint serine/threonine kinase B

increases expression

Lidocaine results in increased expression of BUB1B mRNA

NCBI chr 3:126,017,019...126,069,470
Ensembl chr 3:105,563,138...105,615,547

G

complement C1q C chain

increases expression

Lidocaine results in increased expression of C1QC mRNA

NCBI chr 5:154,410,845...154,414,208
Ensembl chr 5:149,127,415...149,131,017

G

similar to human chromosome 6 open reading frame 132

increases expression

Lidocaine results in increased expression of C9H6ORF132 mRNA

NCBI chr 9:13,524,822...13,561,756
Ensembl chr 9:13,525,395...13,561,585

G

calcitonin-related polypeptide alpha

increases secretion
multiple interactions
increases expression

Lidocaine results in increased secretion of CALCA protein
capsazepine inhibits the reaction [Lidocaine results in increased secretion of CALCA protein]; TRPV1 protein affects the reaction [Lidocaine results in increased secretion of CALCA protein]
Lidocaine inhibits the reaction [Potassium results in increased secretion of CALCA protein]
Lidocaine results in increased expression of CALCA mRNA

PMID:18172555 PMID:18178321 PMID:35283115

NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:168,878,214...168,883,105

G

calcium homeostasis modulator family member 2

increases expression

Lidocaine results in increased expression of CALHM2 mRNA

NCBI chr 1:255,963,661...255,969,387
Ensembl chr 1:246,022,324...246,028,218

G

capping actin protein, gelsolin like

increases expression

Lidocaine results in increased expression of CAPG mRNA

NCBI chr 4:106,152,912...106,170,010
Ensembl chr 4:104,594,753...104,611,856

G

caspase 3

decreases expression
decreases activity
increases activity

Lidocaine results in decreased expression of CASP3 protein
Lidocaine results in decreased activity of CASP3 protein
Lidocaine results in increased activity of CASP3 protein

PMID:15099683 PMID:17585225 PMID:20194319 PMID:21047305

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

decreases expression
increases expression
multiple interactions

Lidocaine results in decreased expression of CASP9 protein
Lidocaine results in increased expression of CASP9 mRNA; Lidocaine results in increased expression of CASP9 protein
cordycepin inhibits the reaction [Lidocaine results in increased expression of CASP9 mRNA]; cordycepin inhibits the reaction [Lidocaine results in increased expression of CASP9 protein]

PMID:20194319 PMID:29382532

Ensembl chr 5:154,109,046...154,126,626

G

coiled-coil domain containing 172

decreases expression

Lidocaine results in decreased expression of CCDC172 mRNA

NCBI chr 1:267,615,341...267,661,568
Ensembl chr 1:257,629,208...257,675,247

G

coiled-coil domain containing 42

decreases expression

Lidocaine results in decreased expression of CCDC42 mRNA

NCBI chr10:53,788,833...53,799,011
Ensembl chr10:53,289,956...53,300,135

G

coiled-coil domain containing 69

increases expression

Lidocaine results in increased expression of CCDC69 mRNA

NCBI chr10:39,673,984...39,701,080
Ensembl chr10:39,173,282...39,199,878

G

coiled-coil domain containing 71-like

decreases expression

Lidocaine results in decreased expression of CCDC71L mRNA

NCBI chr 6:48,960,020...48,964,112
Ensembl chr 6:48,960,191...48,960,841
Ensembl chr 6:48,960,191...48,960,841

G

C-C motif chemokine ligand 19

decreases expression

Lidocaine results in decreased expression of CCL19 mRNA

NCBI chr 5:61,759,220...61,761,164
Ensembl chr 5:56,963,364...56,965,308

G

C-C motif chemokine ligand 2

multiple interactions

Lidocaine inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; Lidocaine inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 20

decreases expression

Lidocaine results in decreased expression of CCL20 mRNA

NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:84,388,904...84,391,629

G

C-C motif chemokine ligand 3

increases expression

Lidocaine results in increased expression of CCL3 mRNA

NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,451,388...68,452,938

G

C-C motif chemokine ligand 4

increases expression

Lidocaine results in increased expression of CCL4 mRNA

NCBI chr10:68,963,893...68,965,728
Ensembl chr10:68,452,052...68,468,231

G

C-C motif chemokine ligand 9

increases expression

Lidocaine results in increased expression of CCL6 mRNA

NCBI chr10:68,863,994...68,868,928
Ensembl chr10:68,366,487...68,371,369

G

cyclin A1

affects expression

Lidocaine affects the expression of CCNA1 mRNA

NCBI chr 2:141,383,352...141,428,205
Ensembl chr 2:139,201,074...139,243,157

G

cyclin A2

affects expression
increases expression

Lidocaine affects the expression of CCNA2 mRNA
Lidocaine results in increased expression of CCNA2 mRNA

PMID:18931217 PMID:35283115

NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:119,426,089...119,433,577

G

cyclin B1

affects expression
increases expression

Lidocaine affects the expression of CCNB1 mRNA
Lidocaine results in increased expression of CCNB1 mRNA

PMID:18931217 PMID:35283115

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172

G

cyclin B2

affects expression
increases expression

Lidocaine affects the expression of CCNB2 mRNA
Lidocaine results in increased expression of CCNB2 mRNA

PMID:18931217 PMID:35283115

NCBI chr 8:79,968,459...79,981,717
Ensembl chr 8:71,087,595...71,100,874

G

cyclin C

affects expression

Lidocaine affects the expression of CCNC mRNA

NCBI chr 5:40,063,589...40,081,731
Ensembl chr 5:35,266,823...35,296,584

G

cyclin D1

affects expression

Lidocaine affects the expression of CCND1 mRNA

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602

G

cyclin E1

affects expression

Lidocaine affects the expression of CCNE1 mRNA

NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:90,781,949...90,791,101

G

cyclin F

affects expression

Lidocaine affects the expression of CCNF mRNA

NCBI chr10:13,757,884...13,783,669
Ensembl chr10:13,253,380...13,279,101

G

C-C motif chemokine receptor 1

decreases expression

Lidocaine results in decreased expression of CCR1 mRNA

NCBI chr 8:132,433,711...132,439,266

G

CD200 receptor 1

increases expression

Lidocaine results in increased expression of CD200R1 mRNA

NCBI chr11:69,392,943...69,427,213
Ensembl chr11:55,887,717...55,921,285

G

Cd276 molecule

increases expression

Lidocaine results in increased expression of CD276 mRNA

NCBI chr 8:67,833,587...67,863,918
Ensembl chr 8:58,937,751...58,968,380

G

CD34 molecule

increases expression

Lidocaine results in increased expression of CD34 mRNA

NCBI chr13:109,008,786...109,029,317
Ensembl chr13:106,480,043...106,499,832

G

Cd48 molecule

increases expression

Lidocaine results in increased expression of CD48 mRNA

NCBI chr13:86,717,960...86,741,540
Ensembl chr13:84,185,532...84,209,142

G

Cd68 molecule

increases expression

Lidocaine results in increased expression of CD68 mRNA

NCBI chr10:54,880,562...54,882,441
Ensembl chr10:54,381,815...54,383,697

G

Cd72 molecule

increases expression

Lidocaine results in increased expression of CD72 mRNA

NCBI chr 5:62,493,155...62,500,779
Ensembl chr 5:57,697,367...57,704,725

G

CD84 molecule

increases expression

Lidocaine results in increased expression of CD84 mRNA

NCBI chr13:86,859,979...86,899,984
Ensembl chr13:84,327,553...84,362,076

G

CD86 molecule

increases expression

Lidocaine results in increased expression of CD86 mRNA

NCBI chr11:77,647,565...77,706,178
Ensembl chr11:64,163,828...64,200,818

G

cell division cycle 20

increases expression

Lidocaine results in increased expression of CDC20 mRNA

NCBI chr 5:137,251,596...137,255,799
Ensembl chr 5:131,966,215...131,970,512

G

cell division cycle 25C

increases expression

Lidocaine results in increased expression of CDC25C mRNA

NCBI chr18:26,608,483...26,630,292
Ensembl chr18:26,335,834...26,356,185

G

cell division cycle 45

increases expression

Lidocaine results in increased expression of CDC45 mRNA

NCBI chr11:95,689,702...95,714,980
Ensembl chr11:82,185,473...82,210,619

G

cell division cycle 6

increases expression

Lidocaine results in increased expression of CDC6 mRNA

NCBI chr10:84,360,361...84,374,239
Ensembl chr10:83,864,638...83,878,011

G

cell division cycle associated 3

increases expression

Lidocaine results in increased expression of CDCA3 mRNA

NCBI chr 4:159,321,203...159,325,072
Ensembl chr 4:157,634,928...157,638,799

G

cell division cycle associated 7

increases expression

Lidocaine results in increased expression of CDCA7 mRNA

NCBI chr 3:77,730,315...77,740,950
Ensembl chr 3:57,322,708...57,333,353

G

cell division cycle associated 7 like

increases expression

Lidocaine results in increased expression of CDCA7L mRNA

NCBI chr 6:144,936,885...144,982,844
Ensembl chr 6:138,794,228...138,839,888

G

cell division cycle associated 8

increases expression

Lidocaine results in increased expression of CDCA8 mRNA

NCBI chr 5:142,461,082...142,483,336
Ensembl chr 5:137,176,417...137,198,629

G

cadherin-related family member 3

decreases expression

Lidocaine results in decreased expression of CDHR3 mRNA

NCBI chr 6:49,641,833...49,702,016
Ensembl chr 6:49,641,813...49,702,017

G

cyclin-dependent kinase 1

increases expression

Lidocaine results in increased expression of CDK1 mRNA

NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,266,248...19,281,408

G

cyclin dependent kinase 2

affects expression
increases expression

Lidocaine affects the expression of CDK2 mRNA
Lidocaine results in increased expression of CDK2 mRNA

PMID:18931217 PMID:35283115

NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase 4

affects expression

Lidocaine affects the expression of CDK4 mRNA

NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase 6

increases expression

Lidocaine results in increased expression of CDK6 mRNA

NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:30,646,460...30,829,634

G

cyclin-dependent kinase-like 4

decreases expression

Lidocaine results in decreased expression of CDKL4 mRNA

NCBI chr 6:20,202,047...20,244,821
Ensembl chr 6:14,450,681...14,492,046

G

cyclin-dependent kinase inhibitor 1A

affects expression
increases expression

Lidocaine affects the expression of CDKN1A mRNA
Lidocaine results in increased expression of CDKN1A mRNA

PMID:18931217 PMID:35283115

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

affects expression

Lidocaine affects the expression of CDKN1B mRNA

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982

G

cyclin-dependent kinase inhibitor 2A

affects expression

Lidocaine affects the expression of CDKN2A mRNA

NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:103,984,949...104,003,149

G

cyclin-dependent kinase inhibitor 2C

increases expression

Lidocaine results in increased expression of CDKN2C mRNA

NCBI chr 5:129,639,736...129,645,564
Ensembl chr 5:124,411,124...124,416,278

G

chromatin licensing and DNA replication factor 1

increases expression

Lidocaine results in increased expression of CDT1 mRNA

NCBI chr19:67,529,249...67,534,195
Ensembl chr19:50,620,713...50,625,659

G

CEA cell adhesion molecule 4

increases expression

Lidocaine results in increased expression of CEACAM4 mRNA

NCBI chr 1:89,504,555...89,510,831
Ensembl chr 1:80,376,648...80,382,915

G

centromere protein A

increases expression

Lidocaine results in increased expression of CENPA mRNA

NCBI chr 6:31,420,062...31,431,703
Ensembl chr 6:25,700,142...25,711,675

G

centromere protein E

increases expression

Lidocaine results in increased expression of CENPE mRNA

NCBI chr 2:226,310,970...226,369,636
Ensembl chr 2:223,636,998...223,695,669

G

centromere protein H

increases expression

Lidocaine results in increased expression of CENPH mRNA

NCBI chr 2:33,630,738...33,644,258
Ensembl chr 2:31,894,667...31,910,154

G

centromere protein M

increases expression

Lidocaine results in increased expression of CENPM mRNA

NCBI chr 7:115,628,117...115,639,401
Ensembl chr 7:113,747,516...113,764,258

G

centromere protein O

increases expression

Lidocaine results in increased expression of CENPO mRNA

NCBI chr 6:32,923,127...32,937,879
Ensembl chr 6:27,188,537...27,218,314

G

centromere protein T

increases expression

Lidocaine results in increased expression of CENPT mRNA

NCBI chr19:33,734,684...33,741,159
Ensembl chr19:33,734,685...33,741,142

G

centromere protein U

increases expression

Lidocaine results in increased expression of CENPU mRNA

NCBI chr16:52,448,446...52,471,662
Ensembl chr16:45,714,294...45,738,823

G

centromere protein W

increases expression

Lidocaine results in increased expression of CENPW mRNA

NCBI chr 1:29,353,939...29,359,109
Ensembl chr 1:27,525,324...27,530,464

G

centrosomal protein 55

increases expression

Lidocaine results in increased expression of CEP55 mRNA

NCBI chr 1:235,832,823...235,848,401
Ensembl chr 1:235,832,878...235,848,394

G

centrosomal protein 72

increases expression

Lidocaine results in increased expression of CEP72 mRNA

NCBI chr 1:31,053,884...31,083,863
Ensembl chr 1:29,225,361...29,255,271

G

carboxylesterase 1D

increases hydrolysis

CES1D protein results in increased hydrolysis of Lidocaine

NCBI chr19:30,046,494...30,085,039
Ensembl chr19:13,796,623...13,912,035

G

carboxylesterase-like 1

decreases expression

Lidocaine results in decreased expression of CESL1 mRNA

NCBI chr19:38,554,365...38,612,663
Ensembl chr19:22,670,712...22,712,608

G

complement factor D

increases expression

Lidocaine results in increased expression of CFD mRNA

NCBI chr 7:10,463,773...10,465,496
Ensembl chr 7:9,813,150...9,815,053

G

cyclic GMP-AMP synthase

increases expression

Lidocaine results in increased expression of CGAS mRNA

NCBI chr 8:88,172,559...88,187,538
Ensembl chr 8:79,294,511...79,305,496

G

chromatin assembly factor 1 subunit B

increases expression

Lidocaine results in increased expression of CHAF1B mRNA

NCBI chr11:46,670,560...46,690,739
Ensembl chr11:33,200,981...33,221,070

G

chondrolectin

decreases expression

Lidocaine results in decreased expression of CHODL mRNA

NCBI chr11:31,141,030...31,163,342
Ensembl chr11:17,654,206...17,676,441

G

chromosome transmission fidelity factor 18

increases expression

Lidocaine results in increased expression of CHTF18 mRNA

NCBI chr10:15,247,525...15,255,573
Ensembl chr10:14,742,621...14,751,050

G

cellular inhibitor of PP2A

increases expression

Lidocaine results in increased expression of CIP2A mRNA

NCBI chr11:65,255,123...65,285,914
Ensembl chr11:51,795,024...51,822,938

G

cytoskeleton associated protein 2

increases expression

Lidocaine results in increased expression of CKAP2 mRNA

NCBI chr16:76,542,114...76,567,297
Ensembl chr16:69,839,630...69,864,913

G

CDC28 protein kinase regulatory subunit 1-like

increases expression

Lidocaine results in increased expression of CKS1L mRNA

NCBI chr 5:112,098,270...112,099,009
Ensembl chr 5:106,982,882...106,983,121

G

CDC28 protein kinase regulatory subunit 2

increases expression

Lidocaine results in increased expression of CKS2 mRNA

NCBI chr17:13,722,360...13,727,519

G

chloride channel calcium activated 4-like

increases expression

Lidocaine results in increased expression of CLCA4L mRNA

NCBI chr 2:236,486,485...236,506,483
Ensembl chr 2:233,826,133...233,846,716

G

cardiotrophin-like cytokine factor 1

increases expression

Lidocaine results in increased expression of CLCF1 mRNA

NCBI chr 1:210,937,763...210,947,064
Ensembl chr 1:201,507,859...201,517,605

G

claudin 14

increases expression

Lidocaine results in increased expression of CLDN14 mRNA

NCBI chr11:46,701,940...46,799,049
Ensembl chr11:33,232,220...33,329,171

G

claudin 23

increases expression

Lidocaine results in increased expression of CLDN23 mRNA

NCBI chr16:63,117,045...63,118,769
Ensembl chr16:56,413,381...56,415,523

G

C-type lectin domain family 12, member A

increases expression

Lidocaine results in increased expression of CLEC12A mRNA

NCBI chr 4:164,484,162...164,502,793
Ensembl chr 4:162,798,125...162,816,753

G

C-type lectin domain family 2, member D

increases expression

Lidocaine results in increased expression of CLEC2D mRNA

NCBI chr 4:163,902,124...163,925,587
Ensembl chr 4:162,216,572...162,239,527

G

C-type lectin domain family 4, member E

decreases expression

Lidocaine results in decreased expression of CLEC4E mRNA

NCBI chr 4:158,292,624...158,298,607
Ensembl chr 4:156,607,614...156,612,767

G

C-type lectin domain containing 7A

increases expression

Lidocaine results in increased expression of CLEC7A mRNA

NCBI chr 4:164,588,737...164,599,953
Ensembl chr 4:162,902,732...162,913,897

G

CKLF-like MARVEL transmembrane domain containing 3

increases expression

Lidocaine results in increased expression of CMTM3 mRNA

NCBI chr19:629,000...637,152
Ensembl chr19:604,458...629,790

G

carnosine dipeptidase 1

increases expression

Lidocaine results in increased expression of CNDP1 mRNA

NCBI chr18:80,254,499...80,305,845
Ensembl chr18:77,984,907...78,007,765

G

cyclic nucleotide gated channel subunit alpha 2

increases expression

Lidocaine results in increased expression of CNGA2 mRNA

NCBI chr X:154,741,742...154,759,814
Ensembl chr X:149,696,997...149,715,051

G

cannabinoid receptor 2

increases expression

Lidocaine results in increased expression of CNR2 mRNA

NCBI chr 5:153,408,968...153,435,092
Ensembl chr 5:148,125,604...148,151,548

G

contactin 5

decreases expression

Lidocaine results in decreased expression of CNTN5 mRNA

NCBI chr 8:15,017,424...16,249,418
Ensembl chr 8:6,738,239...7,967,957

G

contactin associated protein 1

decreases expression

Lidocaine results in decreased expression of CNTNAP1 mRNA

NCBI chr10:86,610,140...86,625,896
Ensembl chr10:86,111,643...86,125,611

G

contactin associated protein family member 3

increases expression

Lidocaine results in increased expression of CNTNAP3 mRNA

NCBI chr17:267,379...455,478
Ensembl chr17:267,508...454,102

G

ceruloplasmin

decreases expression

Lidocaine results in decreased expression of CP mRNA

NCBI chr 2:104,368,336...104,427,119
Ensembl chr 2:102,439,624...102,498,075

G

corticotropin releasing hormone

increases expression

Lidocaine results in increased expression of CRH mRNA

NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:102,143,055...102,144,919

G

cysteine-rich secretory protein LCCL domain containing 1

decreases expression

Lidocaine results in decreased expression of CRISPLD1 mRNA

NCBI chr 5:6,050,970...6,098,265
Ensembl chr 5:1,274,647...1,314,926

G

cartilage associated protein

increases expression

Lidocaine results in increased expression of CRTAP mRNA

NCBI chr 8:122,926,117...122,945,843
Ensembl chr 8:114,047,933...114,067,631

G

colony stimulating factor 2 receptor subunit alpha

increases expression

Lidocaine results in increased expression of CSF2RA mRNA

NCBI chr14:113,219...118,808
Ensembl chr14:89,172...103,128

G

cysteine and glycine rich protein 3

increases expression

Lidocaine results in increased expression of CSRP3 mRNA

NCBI chr 1:107,664,338...107,682,916
Ensembl chr 1:98,528,068...98,546,653

G

cathepsin C

increases expression

Lidocaine results in increased expression of CTSC mRNA

NCBI chr 1:151,440,860...151,472,430
Ensembl chr 1:142,028,392...142,060,387

G

cathepsin Z

increases expression

Lidocaine results in increased expression of CTSZ mRNA

NCBI chr 3:183,643,077...183,653,847
Ensembl chr 3:163,224,875...163,235,645

G

cut-like homeobox 1

increases expression

Lidocaine results in increased expression of CUX1 mRNA

NCBI chr12:25,728,393...26,062,497
Ensembl chr12:20,107,311...20,425,866
Ensembl chr 4:20,107,311...20,425,866

G

C-X-C motif chemokine ligand 1

decreases expression

Lidocaine results in decreased expression of CXCL1 mRNA

NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,193,365...17,195,215

G

C-X-C motif chemokine ligand 12

decreases expression

Lidocaine results in decreased expression of CXCL12 mRNA

NCBI chr 4:152,060,781...152,073,628
Ensembl chr 4:150,388,325...150,401,168

G

C-X-C motif chemokine ligand 13

decreases expression

Lidocaine results in decreased expression of CXCL13 mRNA

NCBI chr14:13,912,858...13,917,920
Ensembl chr14:13,608,902...13,613,933

G

C-X-C motif chemokine ligand 16

increases expression

Lidocaine results in increased expression of CXCL16 mRNA

NCBI chr10:55,665,355...55,669,950
Ensembl chr10:55,166,723...55,171,592

G

cytochrome b-245 beta chain

increases expression

Lidocaine results in increased expression of CYBB mRNA

NCBI chr X:16,030,596...16,065,065
Ensembl chr X:13,359,430...13,392,586

G

cytochrome P450, family 1, subfamily a, polypeptide 2

affects metabolic processing

CYP1A2 protein affects the metabolism of Lidocaine

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 2, subfamily ac, polypeptide 1

decreases expression

Lidocaine results in decreased expression of CYP2AC1 mRNA

NCBI chr 9:20,035,823...20,058,570
Ensembl chr 9:20,033,780...20,058,837

G

cytochrome P450, family 2, subfamily d, polypeptide 1

increases expression

Lidocaine results in increased expression of CYP2D1 mRNA

NCBI chr 7:115,789,026...115,793,430
Ensembl chr 7:113,908,947...113,922,084

G

cytochrome P450, family 2, subfamily d, polypeptide 5

increases expression

Lidocaine results in increased expression of CYP2D5 mRNA

NCBI chr 7:115,779,981...115,784,554
Ensembl chr 7:113,899,890...113,904,495

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
decreases ethylation
affects metabolic processing
decreases methylation
increases metabolic processing

Rifampin promotes the reaction [CYP3A4 protein results in increased metabolism of Lidocaine]
CYP3A4 protein results in decreased ethylation of Lidocaine
CYP3A4 protein affects the metabolism of Lidocaine
CYP3A4 protein results in decreased methylation of Lidocaine

PMID:9298257 PMID:15383492 PMID:15447735 PMID:15887009 PMID:18846481

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 9

decreases methylation

CYP3A5 protein results in decreased methylation of Lidocaine

NCBI chr12:21,919,955...21,960,160
Ensembl chr12:16,806,207...16,846,422

G

cytohesin 1 interacting protein

increases expression

Lidocaine results in increased expression of CYTIP mRNA

NCBI chr 3:63,106,895...63,183,769
Ensembl chr 3:42,698,768...42,725,993

G

death associated protein-like 1

increases expression

Lidocaine results in increased expression of DAPL1 mRNA

NCBI chr 3:64,369,734...64,389,677
Ensembl chr 3:43,960,810...43,980,940

G

DBF4-CDC7 kinase regulatory subunit

increases expression

Lidocaine results in increased expression of DBF4 mRNA

NCBI chr 4:26,631,491...26,656,080
Ensembl chr 4:25,676,634...25,701,066

G

decorin

decreases expression

Lidocaine results in decreased expression of DCN mRNA

NCBI chr 7:34,167,973...34,208,004
Ensembl chr 7:32,281,252...32,321,270

G

DDAH family member 2, ADMA-independent

decreases expression
increases expression

Lidocaine results in decreased expression of DDAH2 protein
Lidocaine results in increased expression of DDAH2 mRNA

NCBI chr20:3,766,115...3,769,161
Ensembl chr20:3,761,465...3,764,511

G

DNA damage-induced apoptosis suppressor

increases expression

Lidocaine results in increased expression of DDIAS mRNA

NCBI chr 1:156,318,559...156,342,869
Ensembl chr 1:146,906,154...146,930,462

G

DEXD/H-box helicase 60

increases expression

Lidocaine results in increased expression of DDX60 mRNA

NCBI chr16:33,087,940...33,208,843
Ensembl chr16:28,076,999...28,179,526

G

DENN domain containing 2D

increases expression

Lidocaine results in increased expression of DENND2D mRNA

NCBI chr 2:196,661,465...196,680,505
Ensembl chr 2:193,973,231...193,992,270

G

DEP domain containing MTOR-interacting protein

multiple interactions

bafilomycin A1 inhibits the reaction [Lidocaine results in decreased expression of [MTOR protein binds to RPTOR protein binds to MLST8 protein binds to PRAS40 protein binds to DEPTOR protein]]; dorsomorphin inhibits the reaction [Lidocaine results in decreased expression of [MTOR protein binds to RPTOR protein binds to MLST8 protein binds to PRAS40 protein binds to DEPTOR protein]]; Lidocaine results in decreased expression of [MTOR protein binds to RPTOR protein binds to MLST8 protein binds to PRAS40 protein binds to DEPTOR protein]; MK-8722 promotes the reaction [Lidocaine results in decreased expression of [MTOR protein binds to RPTOR protein binds to MLST8 protein binds to PRAS40 protein binds to DEPTOR protein]]

NCBI chr 7:88,404,745...88,574,065
Ensembl chr 7:86,514,988...86,667,773

G

diaphanous-related formin 3

increases expression

Lidocaine results in increased expression of DIAPH3 mRNA

NCBI chr15:68,951,992...69,421,623
Ensembl chr15:62,543,375...63,012,975

G

iodothyronine deiodinase 3

decreases expression

Lidocaine results in decreased expression of DIO3 mRNA

NCBI chr 6:135,107,072...135,108,933
Ensembl chr 6:129,285,749...129,286,660

G

DLG associated protein 5

increases expression

Lidocaine results in increased expression of DLGAP5 mRNA

NCBI chr15:23,113,678...23,144,281
Ensembl chr15:20,633,966...20,664,518

G

DnaJ heat shock protein family (Hsp40) member B7

decreases expression

Lidocaine results in decreased expression of DNAJB7 mRNA

NCBI chr 7:114,812,886...114,814,200
Ensembl chr 7:112,932,616...112,945,537

G

DnaJ heat shock protein family (Hsp40) member C22

increases expression

Lidocaine results in increased expression of DNAJC22 mRNA

NCBI chr 7:130,257,504...130,262,880
Ensembl chr 7:130,257,851...130,263,230

G

deoxyribonuclease 2, lysosomal

increases expression

Lidocaine results in increased expression of DNASE2 mRNA

NCBI chr19:40,149,505...40,152,225
Ensembl chr19:23,244,664...23,247,376

G

dedicator of cytokinesis 8

increases expression

Lidocaine results in increased expression of DOCK8 mRNA

NCBI chr 1:232,075,468...232,268,830
Ensembl chr 1:222,649,309...222,842,474

G

dipeptidase 2

increases expression

Lidocaine results in increased expression of DPEP2 mRNA

NCBI chr19:50,795,322...50,806,320
Ensembl chr19:33,885,478...33,891,954

G

diphthamine biosynthesis 6

decreases expression

Lidocaine results in decreased expression of DPH6 mRNA

NCBI chr 3:101,307,229...101,437,463
Ensembl chr 3:101,307,231...101,534,603

G

DNA replication and sister chromatid cohesion 1

increases expression

Lidocaine results in increased expression of DSCC1 mRNA

NCBI chr 7:88,372,349...88,390,815
Ensembl chr 7:86,482,588...86,498,212

G

denticleless E3 ubiquitin protein ligase homolog

decreases expression

Lidocaine results in decreased expression of DTL mRNA

NCBI chr13:105,646,908...105,685,921
Ensembl chr13:103,117,186...103,154,890

G

deltex E3 ubiquitin ligase 4

increases expression

Lidocaine results in increased expression of DTX4 mRNA

NCBI chr 1:218,882,391...218,969,837
Ensembl chr 1:209,460,735...209,492,818

G

E2F transcription factor 1

affects expression

Lidocaine affects the expression of E2F1 mRNA

NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:143,049,478...143,075,361

G

E2F transcription factor 2

affects expression

Lidocaine affects the expression of E2F2 mRNA

NCBI chr 5:153,682,789...153,706,087
Ensembl chr 5:148,399,642...148,421,217

G

E2F transcription factor 3

affects expression
increases expression

Lidocaine affects the expression of E2F3 mRNA
Lidocaine results in increased expression of E2F3 mRNA

PMID:18931217 PMID:35283115

NCBI chr17:34,810,355...34,887,725
Ensembl chr17:34,601,830...34,676,253

G

E2F transcription factor 4

affects expression

Lidocaine affects the expression of E2F4 mRNA

NCBI chr19:50,084,335...50,091,731
Ensembl chr19:33,174,410...33,181,806

G

epithelial cell transforming 2

increases expression

Lidocaine results in increased expression of ECT2 mRNA

NCBI chr 2:111,904,522...111,966,786
Ensembl chr 2:109,975,813...110,037,911

G

EF-hand calcium binding domain 11

increases expression

Lidocaine results in increased expression of EFCAB11 mRNA

NCBI chr 6:124,738,531...124,892,623
Ensembl chr 6:119,008,919...119,162,046

G

early growth response 1

increases expression

Lidocaine results in increased expression of EGR1 mRNA

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,462,981...26,466,766

G

early growth response 2

increases expression

Lidocaine results in increased expression of EGR2 mRNA

NCBI chr20:21,050,149...21,055,201
Ensembl chr20:21,051,277...21,055,562

G

essential meiotic structure-specific endonuclease 1

increases expression

Lidocaine results in increased expression of EME1 mRNA

NCBI chr10:80,083,585...80,092,450
Ensembl chr10:79,586,729...79,595,435

G

epithelial membrane protein 1

increases expression

Lidocaine results in increased expression of EMP1 mRNA

NCBI chr 4:169,931,537...169,964,366
Ensembl chr 4:168,212,861...168,232,904

G

epithelial membrane protein 3

increases expression

Lidocaine results in increased expression of EMP3 mRNA

NCBI chr 1:105,525,086...105,528,370
Ensembl chr 1:96,388,652...96,391,988

G

endo-beta-N-acetylglucosaminidase

increases expression

Lidocaine results in increased expression of ENGASE mRNA

NCBI chr10:103,707,169...103,719,833
Ensembl chr10:103,707,169...103,719,819

G

epithelial cell adhesion molecule

increases expression

Lidocaine results in increased expression of EPCAM mRNA

NCBI chr 6:12,633,715...12,649,678
Ensembl chr 6:6,878,237...6,896,127

G

erythropoietin receptor

increases expression

Lidocaine results in increased expression of EPOR mRNA

NCBI chr 8:28,765,738...28,770,371
Ensembl chr 8:20,489,678...20,494,257

G

epithelial stromal interaction 1

increases expression

Lidocaine results in increased expression of EPSTI1 mRNA

NCBI chr15:59,692,712...59,791,376
Ensembl chr15:53,284,216...53,382,191

G

ERCC excision repair 6 like, spindle assembly checkpoint helicase

increases expression

Lidocaine results in increased expression of ERCC6L mRNA

NCBI chr X:71,285,380...71,301,186
Ensembl chr X:67,245,414...67,280,756

G

establishment of sister chromatid cohesion N-acetyltransferase 2

increases expression

Lidocaine results in increased expression of ESCO2 mRNA

NCBI chr15:44,210,124...44,230,785
Ensembl chr15:40,034,568...40,055,306
Ensembl chr15:40,034,568...40,055,306

G

establishment of cohesion 1 homolog 2 (S. cerevisiae), pseudogene 1

increases expression

Lidocaine results in increased expression of ESCO2-PS1 mRNA

NCBI chr 7:63,948,207...63,951,641

G

endothelial cell-specific molecule 1

decreases expression

Lidocaine results in decreased expression of ESM1 mRNA

NCBI chr 2:46,609,253...46,617,991
Ensembl chr 2:44,876,067...44,884,804

G

extra spindle pole bodies like 1, separase

increases expression

Lidocaine results in increased expression of ESPL1 mRNA

NCBI chr 7:135,302,460...135,329,570
Ensembl chr 7:133,424,130...133,450,984

G

estrogen receptor 1

increases expression

Lidocaine results in increased expression of ESR1 mRNA

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002

G

coagulation factor X

increases expression

Lidocaine results in increased expression of F10 mRNA

NCBI chr16:83,170,973...83,190,280
Ensembl chr16:76,468,838...76,488,141

G

F2R like thrombin or trypsin receptor 3

increases expression

Lidocaine results in increased expression of F2RL3 mRNA

NCBI chr16:17,151,516...17,153,509
Ensembl chr16:17,117,441...17,119,472

G

family with sequence similarity 72, member A

increases expression

Lidocaine results in increased expression of FAM72A mRNA

NCBI chr13:45,519,940...45,531,322
Ensembl chr13:42,967,578...42,984,208

G

FA complementation group D2

increases expression

Lidocaine results in increased expression of FANCD2 mRNA

NCBI chr 4:148,234,633...148,299,035
Ensembl chr 4:146,679,179...146,743,412

G

fibulin 2

increases expression

Lidocaine results in increased expression of FBLN2 mRNA

NCBI chr 4:125,261,464...125,321,030
Ensembl chr 4:123,704,373...123,763,948

G

F-box and leucine-rich repeat protein 21

increases expression

Lidocaine results in increased expression of FBXL21 mRNA

NCBI chr17:8,063,731...8,082,920
Ensembl chr17:8,060,414...8,073,359

G

F-box protein 5

increases expression

Lidocaine results in increased expression of FBXO5 mRNA

NCBI chr 1:44,601,412...44,607,781
Ensembl chr 1:42,196,068...42,202,437

G

Fc receptor-like 2

increases expression

Lidocaine results in increased expression of FCRL2 mRNA

NCBI chr 2:174,992,226...175,005,177
Ensembl chr 2:172,694,308...172,707,051

G

FYVE, RhoGEF and PH domain containing 2

increases expression

Lidocaine results in increased expression of FGD2 mRNA

NCBI chr20:7,426,407...7,443,207
Ensembl chr20:7,424,790...7,441,603

G

fibroblast growth factor 20

decreases expression

Lidocaine results in decreased expression of FGF20 mRNA

NCBI chr16:58,734,003...58,741,650
Ensembl chr16:52,010,194...52,038,204

G

fibroblast growth factor binding protein 1

decreases expression

Lidocaine results in decreased expression of FGFBP1 mRNA

NCBI chr14:71,316,171...71,319,965
Ensembl chr14:67,104,545...67,107,496

G

fidgetin-like 1

increases expression

Lidocaine results in increased expression of FIGNL1 mRNA

NCBI chr14:90,573,090...90,595,342
Ensembl chr14:86,368,675...86,377,455

G

fat storage-inducing transmembrane protein 1

increases expression

Lidocaine results in increased expression of FITM1 mRNA

NCBI chr15:29,064,746...29,066,015
Ensembl chr15:29,064,707...29,066,015

G

filamin C

increases expression

Lidocaine results in increased expression of FLNC mRNA

NCBI chr 4:58,999,445...59,027,240
Ensembl chr 4:58,034,189...58,061,844

G

Fms related receptor tyrosine kinase 3

decreases expression

Lidocaine results in decreased expression of FLT3 mRNA

NCBI chr12:12,660,035...12,735,584
Ensembl chr12:7,623,930...7,699,474

G

flavin-containing monooxygenase 13

decreases expression

Lidocaine results in decreased expression of FMO13 mRNA

NCBI chr13:78,726,398...78,738,178
Ensembl chr13:78,726,398...78,738,178

G

folate receptor beta

increases expression

Lidocaine results in increased expression of FOLR2 mRNA

NCBI chr 1:165,612,047...165,630,382
Ensembl chr 1:156,200,060...156,205,724

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
affects expression

Lidocaine inhibits the reaction [Bee Venoms promotes the reaction [Methamphetamine results in increased expression of FOS protein]]
Lidocaine affects the expression of FOS protein
Lidocaine inhibits the reaction [Propofol results in increased expression of FOS protein]

PMID:7887109 PMID:17136530 PMID:20950675

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036

G

forkhead box O3

multiple interactions

Dexmedetomidine inhibits the reaction [Lidocaine results in increased expression of FOXO3 protein]; SIRT1 protein inhibits the reaction [Lidocaine results in increased expression of FOXO3 protein]
Lidocaine results in increased expression of and results in increased acetylation of FOXO3 protein

NCBI chr20:47,251,968...47,348,254
Ensembl chr20:45,672,995...45,764,561

G

fascin actin-bundling protein 3

increases expression

Lidocaine results in increased expression of FSCN3 mRNA

NCBI chr 4:58,008,124...58,017,674
Ensembl chr 4:57,042,797...57,052,404

G

ferritin light chain 1 like 5

increases expression

Lidocaine results in increased expression of FTL1L5 mRNA

NCBI chr 7:12,295,404...12,871,512
Ensembl chr 7:12,220,103...12,221,023
Ensembl chr 2:12,220,103...12,221,023

G

galactosylceramidase

increases expression

Lidocaine results in increased expression of GALC mRNA

NCBI chr 6:123,182,636...123,252,024
Ensembl chr 6:117,452,895...117,515,830

G

polypeptide N-acetylgalactosaminyltransferase 3

increases expression

Lidocaine results in increased expression of GALNT3 mRNA

NCBI chr 3:71,150,559...71,187,321
Ensembl chr 3:50,742,512...50,766,268

G

golgi associated kinase 1B

increases expression

Lidocaine results in increased expression of FAM198B mRNA

NCBI chr 2:167,345,738...167,410,606
Ensembl chr 2:165,047,684...165,112,477

G

growth differentiation factor 15

increases expression

Lidocaine results in increased expression of GDF15 mRNA

NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,805,239...18,808,055

G

growth differentiation factor 3

increases expression

Lidocaine results in increased expression of GDF3 mRNA

NCBI chr 4:157,503,547...157,507,923
Ensembl chr 4:155,830,909...155,835,937

G

growth differentiation factor 7

decreases expression

Lidocaine results in decreased expression of GDF7 mRNA

NCBI chr 6:36,890,799...36,901,783
Ensembl chr 6:31,178,119...31,182,447

G

glial cell derived neurotrophic factor

increases expression

Lidocaine results in increased expression of GDNF mRNA

NCBI chr 2:58,621,327...58,647,242
Ensembl chr 2:56,895,010...56,917,209

G

GEN1 Holliday junction 5' flap endonuclease

increases expression

Lidocaine results in increased expression of GEN1 mRNA

NCBI chr 6:39,666,675...39,697,480
Ensembl chr 6:33,948,206...33,978,401

G

GINS complex subunit 1

increases expression

Lidocaine results in increased expression of GINS1 mRNA

NCBI chr 3:160,184,920...160,206,334
Ensembl chr 3:139,724,490...139,745,936

G

gliomedin

increases expression

Lidocaine results in increased expression of GLDN mRNA

NCBI chr 8:63,575,270...63,619,346
Ensembl chr 8:54,679,119...54,723,196

G

GLI pathogenesis-related 1

increases expression

Lidocaine results in increased expression of GLIPR1 mRNA

NCBI chr 7:49,373,579...49,399,190
Ensembl chr 7:47,487,345...47,498,429

G

G protein subunit beta 2

increases expression

Lidocaine results in increased expression of GNB2 mRNA; Lidocaine results in increased expression of GNB2 protein

NCBI chr12:24,795,505...24,800,796
Ensembl chr12:19,158,973...19,164,019

G

glycoprotein nmb

increases expression

Lidocaine results in increased expression of GPNMB mRNA

NCBI chr 4:79,341,128...79,362,366
Ensembl chr 4:78,010,197...78,049,367

G

G protein-coupled receptor 182

decreases expression

Lidocaine results in decreased expression of GPR182 mRNA

NCBI chr 7:65,471,254...65,474,110
Ensembl chr 7:63,578,750...63,589,210

G

G protein-coupled receptor 31

increases expression

Lidocaine results in increased expression of GPR31 mRNA

NCBI chr 1:55,474,484...55,475,443

G

G protein-coupled receptor 34

increases expression

Lidocaine results in increased expression of GPR34 mRNA

NCBI chr X:11,777,667...11,786,640
Ensembl chr X:9,104,565...9,148,601

G

G-protein coupled receptor 65

increases expression

Lidocaine results in increased expression of GPR65 mRNA

NCBI chr 6:123,245,534...123,262,758
Ensembl chr 6:117,515,648...117,536,512

G

granulin precursor

increases expression

Lidocaine results in increased expression of GRN mRNA

NCBI chr10:87,887,834...87,893,938
Ensembl chr10:87,387,638...87,393,775

G

germ cell associated 1

increases expression

Lidocaine results in increased expression of GSG1 mRNA

NCBI chr 4:168,090,773...168,107,039
Ensembl chr 4:168,090,776...168,107,039

G

H19 imprinted maternally expressed transcript

increases expression

Lidocaine results in increased expression of H19 mRNA

NCBI chr 1:207,160,175...207,162,851
Ensembl chr 1:197,730,698...197,733,134

G

H2A clustered histone 25

decreases expression

Lidocaine results in decreased expression of H2AC25 mRNA

NCBI chr10:44,233,283...44,234,835
Ensembl chr10:43,733,668...43,744,874

G

histone H3 associated protein kinase

increases expression

Lidocaine results in increased expression of GSG2 mRNA

NCBI chr10:58,246,244...58,249,031
Ensembl chr10:57,747,573...57,750,512

G

hepatitis A virus cellular receptor 1

increases expression

Lidocaine results in increased expression of HAVCR1 mRNA

NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,119,088...31,151,698

G

hepatitis A virus cellular receptor 2

increases expression

Lidocaine results in increased expression of HAVCR2 mRNA

NCBI chr10:31,383,801...31,415,334
Ensembl chr10:30,882,606...30,909,137

G

heparin-binding EGF-like growth factor

increases expression

Lidocaine results in increased expression of HBEGF mRNA

NCBI chr18:28,380,337...28,390,220
Ensembl chr18:28,105,760...28,116,441

G

hematopoietic cell specific Lyn substrate 1

increases expression

Lidocaine results in increased expression of HCLS1 mRNA

NCBI chr11:77,322,873...77,346,333
Ensembl chr11:63,817,476...63,841,014

G

hematopoietic cell signal transducer

increases expression

Lidocaine results in increased expression of HCST mRNA

NCBI chr 1:94,804,429...94,806,661
Ensembl chr 1:85,676,979...85,679,012

G

heme binding protein 2

decreases expression

Lidocaine results in decreased expression of HEBP2 mRNA

NCBI chr 1:15,014,729...15,021,523
Ensembl chr 1:13,194,982...13,201,777

G

homogentisate 1, 2-dioxygenase

increases expression

Lidocaine results in increased expression of HGD mRNA

NCBI chr11:76,592,202...76,643,776
Ensembl chr11:63,086,752...63,138,323

G

histone linker H1 domain, spermatid-specific 1

increases expression

Lidocaine results in increased expression of HILS1 mRNA

NCBI chr10:80,410,361...80,411,157
Ensembl chr10:79,913,480...79,914,321

G

histone cluster 1 H2A family member F

increases expression

Lidocaine results in increased expression of HIST1H2AF mRNA

NCBI chr17:41,807,261...41,807,653
Ensembl chr17:41,379,404...41,379,796

G

histone cluster 1 H2A family member H

increases expression

Lidocaine results in increased expression of HIST1H2AH mRNA

NCBI chr17:41,812,378...41,812,875

G

hexokinase 3

increases expression

Lidocaine results in increased expression of HK3 mRNA

NCBI chr17:9,602,119...9,620,038
Ensembl chr17:9,599,865...9,614,863

G

high mobility group box 1

multiple interactions

Lidocaine inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased localization of HMGB1 protein]; Lidocaine inhibits the reaction [Lipopolysaccharides results in increased expression of HMGB1 mRNA]

NCBI chr12:11,009,236...11,015,941
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

high mobility group box 2

increases expression

Lidocaine results in increased expression of HMGB2 mRNA

NCBI chr16:37,721,374...37,723,950
Ensembl chr16:32,710,658...32,713,140
Ensembl chr 1:32,710,658...32,713,140

G

high mobility group box 2, pseudogene 6

increases expression

Lidocaine results in increased expression of HMGB2-PS6 mRNA

NCBI chr 1:19,409,161...19,410,260
Ensembl chr 1:19,409,539...19,410,168

G

high mobility group box 2-like 1

increases expression

Lidocaine results in increased expression of HMGB2L1 mRNA

NCBI chr11:60,721,545...60,722,608
Ensembl chr11:47,252,569...47,253,669
Ensembl chr 1:47,252,569...47,253,669

G

high mobility group box 2 like 2

increases expression

Lidocaine results in increased expression of HMGB2L2 mRNA

NCBI chr14:73,258,013...73,258,780
Ensembl chr14:69,045,641...69,046,640
Ensembl chr 1:69,045,641...69,046,640

G

hyaluronan-mediated motility receptor

increases expression

Lidocaine results in increased expression of HMMR mRNA

NCBI chr10:25,635,249...25,665,389
Ensembl chr10:25,132,977...25,163,060

G

heme oxygenase 1

increases expression

Lidocaine results in increased expression of HMOX1 mRNA

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079

G

HORMA domain containing 2

increases expression

Lidocaine results in increased expression of HORMAD2 mRNA

NCBI chr14:83,438,555...83,524,015
Ensembl chr14:79,214,998...79,299,910

G

15-hydroxyprostaglandin dehydrogenase

increases expression

Lidocaine results in increased expression of HPGD mRNA

NCBI chr16:38,996,876...39,034,831
Ensembl chr16:33,986,266...34,024,228

G

hematopoietic prostaglandin D synthase

increases expression

Lidocaine results in increased expression of HPGDS mRNA

NCBI chr 4:95,698,265...95,727,733
Ensembl chr 4:94,373,342...94,397,883

G

histamine receptor H 1

affects binding
multiple interactions

HRH1 protein binds to Lidocaine
[HRH1 protein binds to Lidocaine] which results in increased import of Calcium

NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:147,645,995...147,647,455

G

heat shock protein family A (Hsp70) member 1B

increases expression

Lidocaine results in increased expression of HSPA1B mRNA

NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240

G

hydrogen voltage-gated channel 1

increases expression

Lidocaine results in increased expression of HVCN1 mRNA

NCBI chr12:40,001,205...40,030,671
Ensembl chr12:34,335,190...34,370,141

G

IFI30, lysosomal thiol reductase

increases expression

Lidocaine results in increased expression of IFI30 mRNA

NCBI chr16:18,709,570...18,713,635
Ensembl chr16:18,675,613...18,681,175

G

interferon-induced protein 44-like

increases expression

Lidocaine results in increased expression of IFI44L mRNA

NCBI chr 2:243,328,629...243,366,404
Ensembl chr 2:240,668,713...240,706,359

G

interferon-induced protein with tetratricopeptide repeats 1B-like

decreases expression

Lidocaine results in decreased expression of IFIT1BL mRNA

NCBI chr 1:241,535,776...241,580,476
Ensembl chr 1:232,122,562...232,167,518

G

insulin-like growth factor 1

increases expression

Lidocaine results in increased expression of IGF1 mRNA

NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor binding protein 2

increases expression

Lidocaine results in increased expression of IGFBP2 mRNA

NCBI chr 9:81,864,811...81,892,179
Ensembl chr 9:74,415,546...74,442,937

G

interleukin 10 receptor subunit alpha

increases expression

Lidocaine results in increased expression of IL10RA mRNA

NCBI chr 8:54,459,754...54,474,786
Ensembl chr 8:45,563,137...45,578,061

G

interleukin 13

decreases expression

Lidocaine results in decreased expression of IL13 protein

NCBI chr10:38,290,926...38,293,483
Ensembl chr10:37,790,130...37,792,737

G

interleukin 16

increases expression

Lidocaine results in increased expression of IL16 mRNA

NCBI chr 1:147,026,852...147,127,177
Ensembl chr 1:137,617,944...137,718,130

G

interleukin 1 receptor accessory protein

increases expression

Lidocaine results in increased expression of IL1RAP mRNA

NCBI chr11:87,567,813...87,704,346
Ensembl chr11:74,070,304...74,199,530

G

interleukin 33

increases expression

Lidocaine results in increased expression of IL33 mRNA

NCBI chr 1:237,115,478...237,149,897
Ensembl chr 1:227,721,435...227,736,373

G

interleukin 4

decreases expression

Lidocaine results in decreased expression of IL4 protein

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

decreases expression

Lidocaine results in decreased expression of IL6 protein

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178

G

innate immunity activator

increases expression

Lidocaine results in increased expression of INAVA mRNA

NCBI chr13:50,218,149...50,238,430
Ensembl chr13:47,666,447...47,686,729

G

inhibitory synaptic factor family member 2B

decreases expression

Lidocaine results in decreased expression of INSYN2B mRNA

NCBI chr10:19,420,561...19,528,006
Ensembl chr10:19,003,131...19,022,139

G

IQ motif containing GTPase activating protein 3

increases expression

Lidocaine results in increased expression of IQGAP3 mRNA

NCBI chr 2:175,840,001...175,881,799
Ensembl chr 2:173,542,110...173,583,956

G

interleukin-1 receptor-associated kinase 2

increases expression

Lidocaine results in increased expression of IRAK2 mRNA

NCBI chr 4:148,341,704...148,398,211
Ensembl chr 4:146,786,100...146,842,602

G

interferon regulatory factor 5

increases expression

Lidocaine results in increased expression of IRF5 mRNA

NCBI chr 4:59,092,914...59,104,596
Ensembl chr 4:58,127,640...58,139,267

G

interferon regulatory factor 8

increases expression

Lidocaine results in increased expression of IRF8 mRNA

NCBI chr19:65,699,284...65,721,066
Ensembl chr19:48,790,588...48,811,829

G

interferon stimulated exonuclease gene 20

increases expression

Lidocaine results in increased expression of ISG20 mRNA

NCBI chr 1:142,234,729...142,246,403
Ensembl chr 1:132,815,123...132,837,027

G

integrin subunit alpha 4

increases expression

Lidocaine results in increased expression of ITGA4 mRNA

NCBI chr 3:84,569,487...84,646,276
Ensembl chr 3:64,163,085...64,233,715

G

integrin subunit alpha 5

increases expression

Lidocaine results in increased expression of ITGA5 mRNA

NCBI chr 7:136,358,097...136,381,305
Ensembl chr 7:134,478,968...134,502,837

G

integrin subunit alpha M

multiple interactions
increases expression

Lidocaine inhibits the reaction [TNF protein results in increased expression of [ITGAM protein binds to ITGB2 protein]]
Lidocaine results in increased expression of ITGAM mRNA

PMID:9336308 PMID:35283115

NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:182,659,000...182,709,503

G

integrin subunit alpha X

increases expression

Lidocaine results in increased expression of ITGAX mRNA

NCBI chr 1:192,140,089...192,171,151
Ensembl chr 1:182,719,609...182,740,698

G

integrin subunit beta 2

multiple interactions

Lidocaine inhibits the reaction [TNF protein results in increased expression of [ITGAM protein binds to ITGB2 protein]]

NCBI chr20:11,061,009...11,097,242
Ensembl chr20:11,061,430...11,097,600

G

intersectin 1

increases expression

Lidocaine results in increased expression of ITSN1 mRNA

NCBI chr11:44,464,515...44,646,598
Ensembl chr11:30,978,590...31,160,645

G

IZUMO family member 2

decreases expression

Lidocaine results in decreased expression of IZUMO2 mRNA

NCBI chr 1:95,196,459...95,209,131
Ensembl chr 1:95,196,459...95,209,092

G

jagged canonical Notch ligand 1

decreases expression

Lidocaine results in decreased expression of JAG1 mRNA

NCBI chr 3:144,859,453...144,894,883
Ensembl chr 3:124,406,794...124,442,209

G

potassium voltage-gated channel subfamily B member 2

decreases expression

Lidocaine results in decreased expression of KCNB2 mRNA

NCBI chr 5:8,340,085...8,811,184
Ensembl chr 5:3,569,685...4,028,599

G

potassium voltage-gated channel subfamily H member 2

decreases activity

Lidocaine results in decreased activity of KCNH2 protein

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:10,826,928...10,859,008

G

potassium two pore domain channel subfamily K member 18

multiple interactions

Lidocaine inhibits the reaction [KCNK18 protein results in increased transport of Potassium]

NCBI chr 1:268,360,738...268,375,012
Ensembl chr 1:258,374,671...258,388,945

G

potassium two pore domain channel subfamily K member 9

multiple interactions

Lidocaine inhibits the reaction [KCNK9 protein results in increased transport of Potassium]

NCBI chr 7:106,316,783...106,362,452
Ensembl chr 7:104,437,934...104,473,175

G

potassium calcium-activated channel subfamily N member 4

increases expression

Lidocaine results in increased expression of KCNN4 mRNA

NCBI chr 1:89,084,306...89,102,279
Ensembl chr 1:79,959,322...79,974,340

G

potassium channel tetramerization domain containing 19

decreases expression

Lidocaine results in decreased expression of KCTD19 mRNA

NCBI chr19:50,169,814...50,202,121
Ensembl chr19:33,259,970...33,292,006

G

kinesin family member 11

increases expression

Lidocaine results in increased expression of KIF11 mRNA

NCBI chr 1:244,494,916...244,589,250
Ensembl chr 1:235,124,316...235,176,766

G

kinesin family member 14

increases expression

Lidocaine results in increased expression of KIF14 mRNA

NCBI chr13:50,478,646...50,542,256
Ensembl chr13:47,927,044...47,989,164

G

kinesin family member 18A

increases expression

Lidocaine results in increased expression of KIF18A mRNA

NCBI chr 3:116,219,007...116,279,378
Ensembl chr 3:95,764,388...95,824,582

G

kinesin family member 18B

increases expression

Lidocaine results in increased expression of KIF18B mRNA

NCBI chr10:88,370,520...88,392,388
Ensembl chr10:87,870,428...87,889,850

G

kinesin family member 20A

increases expression

Lidocaine results in increased expression of KIF20A mRNA

NCBI chr18:26,504,422...26,512,908
Ensembl chr18:26,230,230...26,238,780

G

kinesin family member 22

increases expression

Lidocaine results in increased expression of KIF22 mRNA

NCBI chr 1:191,065,875...191,080,955
Ensembl chr 1:181,635,183...181,650,401

G

kinesin family member 28

decreases expression

Lidocaine results in decreased expression of KIF28P mRNA

NCBI chr13:93,959,492...94,014,255
Ensembl chr13:91,427,736...91,482,237

G

kinesin family member C1

increases expression

Lidocaine results in increased expression of KIFC1 mRNA

NCBI chr20:5,000,929...5,018,967
Ensembl chr20:4,999,047...5,017,105

G

kinesin light chain 1

decreases expression

Lidocaine results in decreased expression of KLC1 mRNA

NCBI chr 6:136,644,592...136,690,399
Ensembl chr 6:130,823,419...130,867,031

G

kelch-like family member 38

increases expression

Lidocaine results in increased expression of KLHL38 mRNA

NCBI chr 7:91,744,634...91,753,843
Ensembl chr 7:89,855,148...89,864,276

G

kelch-like family member 6

increases expression

Lidocaine results in increased expression of KLHL6 mRNA

NCBI chr11:94,475,262...94,514,653
Ensembl chr11:80,970,917...81,009,677

G

kynurenine 3-monooxygenase

increases expression

Lidocaine results in increased expression of KMO mRNA

NCBI chr13:90,089,340...90,121,108
Ensembl chr13:87,557,286...87,588,881

G

kininogen 1

multiple interactions
decreases activity

Lidocaine inhibits the reaction [[Propofol co-treated with Pharmaceutical Vehicles] results in increased expression of KNG1 protein modified form]
Lidocaine results in decreased activity of KNG1 protein

PMID:1371395 PMID:10655909

NCBI chr11:91,317,354...91,340,148
Ensembl chr11:77,812,752...77,835,555

G

kinetochore-localized astrin/SPAG5 binding protein

increases expression

Lidocaine results in increased expression of KNSTRN mRNA

NCBI chr 3:126,254,633...126,274,412
Ensembl chr 3:105,800,954...105,820,715

G

kinetochore associated 1

increases expression

Lidocaine results in increased expression of KNTC1 mRNA

NCBI chr12:38,429,925...38,500,564
Ensembl chr12:32,769,020...32,839,561

G

karyopherin subunit alpha 2

increases expression

Lidocaine results in increased expression of KPNA2 mRNA

NCBI chr10:92,433,678...92,445,841
Ensembl chr10:91,933,951...91,946,150

G

karyopherin subunit alpha 7

decreases expression

Lidocaine results in decreased expression of KPNA7 mRNA

NCBI chr12:14,690,124...14,728,478
Ensembl chr12:9,576,378...9,612,833

G

keratin 34

decreases expression

Lidocaine results in decreased expression of KRT34 mRNA

NCBI chr10:85,470,391...85,474,501
Ensembl chr10:84,970,017...84,974,040

G

keratin 8

increases expression

Lidocaine results in increased expression of KRT8 mRNA

NCBI chr 7:135,002,886...135,010,339
Ensembl chr 7:133,124,203...133,131,728

G

lactalbumin, alpha

decreases expression

Lidocaine results in decreased expression of LALBA mRNA

NCBI chr 7:131,504,572...131,520,707
Ensembl chr 7:129,625,535...129,628,061

G

lysosomal protein transmembrane 5

increases expression

Lidocaine results in increased expression of LAPTM5 mRNA

NCBI chr 5:148,371,880...148,393,927
Ensembl chr 5:143,087,759...143,109,807

G

lymphocyte cytosolic protein 1

increases expression

Lidocaine results in increased expression of LCP1 mRNA

NCBI chr15:56,846,375...56,954,090
Ensembl chr15:50,488,149...50,544,680

G

lymphocyte cytosolic protein 2

increases expression

Lidocaine results in increased expression of LCP2 mRNA

NCBI chr10:19,146,846...19,193,750
Ensembl chr10:18,642,658...18,689,559

G

galectin 1

decreases expression

Lidocaine results in decreased expression of LGALS1 protein

NCBI chr 7:112,365,695...112,368,801
Ensembl chr 7:110,481,392...110,488,345

G

galectin 12

decreases expression

Lidocaine results in decreased expression of LGALS12 mRNA

NCBI chr 1:214,261,216...214,272,825
Ensembl chr 1:204,832,065...204,842,759

G

galectin 3 binding protein

increases expression

Lidocaine results in increased expression of LGALS3BP mRNA

NCBI chr10:104,118,510...104,127,848
Ensembl chr10:103,619,908...103,629,256

G

leukocyte immunoglobulin-like receptor, subfamily C, member 2

decreases expression

Lidocaine results in decreased expression of LILRC2 mRNA

NCBI chr 1:65,272,134...65,277,278
Ensembl chr 1:65,272,796...65,277,271

G

LIM domain kinase 2

increases expression

Lidocaine results in increased expression of LIMK2 mRNA

NCBI chr14:82,384,256...82,509,755
Ensembl chr14:78,218,063...78,286,007

G

lipoprotein lipase

increases expression

Lidocaine results in increased expression of LPL mRNA

NCBI chr16:25,596,205...25,621,928
Ensembl chr16:20,829,465...20,855,249

G

leupaxin

increases expression

Lidocaine results in increased expression of LPXN mRNA

NCBI chr 1:219,353,319...219,387,743
Ensembl chr 1:209,929,202...209,963,084

G

leucine rich repeat protein 1

increases expression

Lidocaine results in increased expression of LRR1 mRNA

NCBI chr 6:87,643,195...87,651,894
Ensembl chr 6:87,643,217...87,651,894

G

leucine rich repeat containing 8 VRAC subunit E

increases expression

Lidocaine results in increased expression of LRRC8E mRNA

NCBI chr12:7,376,103...7,387,250
Ensembl chr12:2,578,315...2,589,412

G

LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated

increases expression

Lidocaine results in increased expression of LSM2 mRNA

NCBI chr20:3,848,120...3,853,298
Ensembl chr20:3,843,466...3,847,266

G

leukocyte specific transcript 1

increases expression

Lidocaine results in increased expression of LST1 mRNA

NCBI chr20:3,639,353...3,644,399
Ensembl chr20:3,634,749...3,637,997

G

Ly49 inhibitory receptor 9

increases expression

Lidocaine results in increased expression of LY49I9 mRNA

G

Ly49 stimulatory receptor 7

increases expression

Lidocaine results in increased expression of LY49S7 mRNA

NCBI chr 4:164,761,847...164,779,735
Ensembl chr 4:164,761,855...164,779,735

G

LYL1, basic helix-loop-helix family member

increases expression

Lidocaine results in increased expression of LYL1 mRNA

NCBI chr19:40,356,967...40,359,834
Ensembl chr19:23,452,140...23,455,007

G

mitotic arrest deficient 2 like 1

increases expression

Lidocaine results in increased expression of MAD2L1 mRNA

NCBI chr 4:97,236,419...97,247,603
Ensembl chr 4:95,906,817...95,913,470

G

MAGE family member B11 like 1

decreases expression

Lidocaine results in decreased expression of MAGEB11L1 mRNA

NCBI chr X:56,619,858...56,621,033
Ensembl chr X:56,619,985...56,621,013

G

MAM and LDL receptor class A domain containing 1

increases expression

Lidocaine results in increased expression of MALRD1 mRNA

NCBI chr17:83,327,372...84,039,558
Ensembl chr17:78,418,819...79,131,016

G

mannosidase, alpha, class 2B, member 1

increases expression

Lidocaine results in increased expression of MAN2B1 mRNA

NCBI chr19:39,959,964...39,979,299
Ensembl chr19:23,055,097...23,074,389

G

mannosidase, alpha, class 2B, member 2

increases expression

Lidocaine results in increased expression of MAN2B2 mRNA

NCBI chr14:73,969,079...73,994,089
Ensembl chr14:73,969,003...74,004,281

G

microtubule-associated protein 1 light chain 3 alpha

increases expression
multiple interactions

Lidocaine results in increased expression of MAP1LC3A protein
bafilomycin A1 inhibits the reaction [Lidocaine results in increased expression of MAP1LC3A protein]; dorsomorphin inhibits the reaction [Lidocaine results in increased expression of MAP1LC3A protein]; MK-8722 promotes the reaction [Lidocaine results in increased expression of MAP1LC3A protein]

NCBI chr 3:164,243,204...164,244,850
Ensembl chr 3:143,783,024...143,784,670

G

mitogen activated protein kinase kinase kinase kinase 1

increases expression

Lidocaine results in increased expression of MAP4K1 mRNA

NCBI chr 1:93,398,460...93,419,996
Ensembl chr 1:84,271,069...84,292,493

G

mitogen activated protein kinase 1

multiple interactions

Lidocaine inhibits the reaction [Capsaicin results in increased phosphorylation of and results in increased activity of MAPK1 protein]

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

Lidocaine inhibits the reaction [Capsaicin results in increased phosphorylation of and results in increased activity of MAPK3 protein]

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863

G

microtubule associated serine/threonine kinase-like

increases expression

Lidocaine results in increased expression of MASTL mRNA

NCBI chr17:90,158,592...90,195,550
Ensembl chr17:85,251,997...85,287,353

G

myelin basic protein

decreases expression
multiple interactions

Lidocaine results in decreased expression of MBP mRNA; Lidocaine results in decreased expression of MBP protein
[Antagomirs results in decreased expression of MIR199A2 mRNA] inhibits the reaction [Lidocaine results in decreased expression of MBP mRNA]; [Antagomirs results in decreased expression of MIR199A2 mRNA] inhibits the reaction [Lidocaine results in decreased expression of MBP protein]

NCBI chr18:78,130,652...78,241,174
Ensembl chr18:75,855,878...75,966,404

G

MCL1 apoptosis regulator, BCL2 family member

increases expression

Lidocaine results in increased expression of MCL1 mRNA

NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:183,219,220...183,222,303

G

minichromosome maintenance 10 replication initiation factor

increases expression

Lidocaine results in increased expression of MCM10 mRNA

NCBI chr17:78,172,049...78,197,644
Ensembl chr17:73,266,095...73,287,364

G

minichromosome maintenance complex component 2

increases expression

Lidocaine results in increased expression of MCM2 mRNA

NCBI chr 4:122,903,679...122,918,205
Ensembl chr 4:121,346,434...121,360,847

G

minichromosome maintenance complex component 3

increases expression

Lidocaine results in increased expression of MCM3 mRNA

NCBI chr 9:30,715,602...30,733,746
Ensembl chr 9:23,219,169...23,237,314

G

minichromosome maintenance complex component 4

increases expression

Lidocaine results in increased expression of MCM4 mRNA

NCBI chr11:98,762,599...98,776,300
Ensembl chr11:85,258,443...85,272,144

G

minichromosome maintenance complex component 5

increases expression

Lidocaine results in increased expression of MCM5 mRNA

NCBI chr19:13,488,813...13,510,131
Ensembl chr19:13,483,066...13,504,389

G

minichromosome maintenance complex component 6

increases expression

Lidocaine results in increased expression of MCM6 mRNA

NCBI chr13:42,379,161...42,404,352
Ensembl chr13:39,826,763...39,851,960

G

mesenchyme homeobox 1

decreases expression

Lidocaine results in decreased expression of MEOX1 mRNA

NCBI chr10:87,318,668...87,338,169
Ensembl chr10:86,818,478...86,837,660

G

MER proto-oncogene, tyrosine kinase

increases expression

Lidocaine results in increased expression of MERTK mRNA

NCBI chr 3:136,391,936...136,498,366
Ensembl chr 3:115,939,351...116,046,554

G

mast cell immunoglobulin-like receptor 1

increases expression

Lidocaine results in increased expression of MILR1 mRNA

NCBI chr10:92,184,002...92,205,001
Ensembl chr10:91,687,831...91,705,282

G

microRNA 199a-2

multiple interactions
increases expression

[Antagomirs results in decreased expression of MIR199A2 mRNA] inhibits the reaction [Lidocaine results in decreased expression of MBP mRNA]; [Antagomirs results in decreased expression of MIR199A2 mRNA] inhibits the reaction [Lidocaine results in decreased expression of MBP protein]; [Antagomirs results in decreased expression of MIR199A2 mRNA] inhibits the reaction [Lidocaine results in decreased expression of MOG mRNA]; [Antagomirs results in decreased expression of MIR199A2 mRNA] inhibits the reaction [Lidocaine results in decreased expression of MYRF mRNA]; [Antagomirs results in decreased expression of MIR199A2 mRNA] inhibits the reaction [Lidocaine results in decreased expression of MYRF protein]; [Antagomirs results in decreased expression of MIR199A2 mRNA] inhibits the reaction [Lidocaine results in decreased expression of PLP1 mRNA]
Lidocaine results in increased expression of MIR199A2 mRNA

NCBI chr13:77,116,225...77,116,334
Ensembl chr13:74,582,954...74,583,063

G

MIS18 kinetochore protein A

increases expression

Lidocaine results in increased expression of MIS18A mRNA

NCBI chr11:43,454,129...43,467,157
Ensembl chr11:29,967,701...29,981,062

G

MIS18 binding protein 1

increases expression

Lidocaine results in increased expression of MIS18BP1 mRNA

NCBI chr 6:88,918,743...88,968,225
Ensembl chr 6:83,182,499...83,231,383

G

MTOR associated protein, LST8 homolog

multiple interactions

bafilomycin A1 inhibits the reaction [Lidocaine results in decreased expression of [MTOR protein binds to RPTOR protein binds to MLST8 protein binds to PRAS40 protein binds to DEPTOR protein]]; dorsomorphin inhibits the reaction [Lidocaine results in decreased expression of [MTOR protein binds to RPTOR protein binds to MLST8 protein binds to PRAS40 protein binds to DEPTOR protein]]; Lidocaine results in decreased expression of [MTOR protein binds to RPTOR protein binds to MLST8 protein binds to PRAS40 protein binds to DEPTOR protein]; MK-8722 promotes the reaction [Lidocaine results in decreased expression of [MTOR protein binds to RPTOR protein binds to MLST8 protein binds to PRAS40 protein binds to DEPTOR protein]]

NCBI chr10:14,002,927...14,008,678
Ensembl chr10:13,498,388...13,504,128

G

matrix metallopeptidase 12

increases expression

Lidocaine results in increased expression of MMP12 mRNA

NCBI chr 8:12,866,652...12,876,554
Ensembl chr 8:4,581,785...4,599,611

G

matrix metallopeptidase 3

multiple interactions
increases expression

cordycepin inhibits the reaction [Lidocaine results in increased expression of MMP3 mRNA]; cordycepin inhibits the reaction [Lidocaine results in increased expression of MMP3 protein]
Lidocaine results in increased expression of MMP3 mRNA; Lidocaine results in increased expression of MMP3 protein

NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:4,640,416...4,653,961

G

matrix metallopeptidase 7

increases expression

Lidocaine results in increased expression of MMP7 mRNA

NCBI chr 8:13,133,043...13,140,761
Ensembl chr 8:4,848,186...4,855,902

G

MMS22-like, DNA repair protein

increases expression

Lidocaine results in increased expression of MMS22L mRNA

NCBI chr 5:42,994,382...43,110,371
Ensembl chr 5:38,197,779...38,313,745

G

myeloid cell nuclear differentiation antigen

increases expression

Lidocaine results in increased expression of PYHIN1 mRNA

NCBI chr13:88,550,224...88,567,892
Ensembl chr13:86,017,892...86,034,201

G

myelin-associated oligodendrocyte basic protein

decreases expression

Lidocaine results in decreased expression of MOBP mRNA

NCBI chr 8:128,747,117...128,777,238
Ensembl chr 8:119,869,626...119,899,563

G

myelin oligodendrocyte glycoprotein

multiple interactions
decreases expression

[Antagomirs results in decreased expression of MIR199A2 mRNA] inhibits the reaction [Lidocaine results in decreased expression of MOG mRNA]

NCBI chr20:1,514,110...1,528,716
Ensembl chr20:1,513,239...1,523,474

G

membrane spanning 4-domains A1

decreases expression

Lidocaine results in decreased expression of MS4A1 mRNA

NCBI chr 1:217,331,274...217,351,934
Ensembl chr 1:207,906,374...207,918,512

G

membrane spanning 4-domains A4A

increases expression

Lidocaine results in increased expression of MS4A4A mRNA

NCBI chr 1:217,495,704...217,510,019
Ensembl chr 1:208,046,971...208,085,119

G

membrane-spanning 4-domains, subfamily A, member 6B-like 1

increases expression

Lidocaine results in increased expression of MS4A6BL1 mRNA

NCBI chr 1:208,243,561...208,255,400
Ensembl chr 1:208,243,559...208,257,340

G

macrophage scavenger receptor 1

increases expression

Lidocaine results in increased expression of MSR1 mRNA

NCBI chr16:59,421,250...59,507,070
Ensembl chr16:52,717,732...52,799,676

G

msh homeobox 3

decreases expression

Lidocaine results in decreased expression of MSX3 mRNA

NCBI chr 1:204,268,688...204,271,881
Ensembl chr 1:194,839,041...194,841,969

G

MDM2 binding protein

increases expression

Lidocaine results in increased expression of MTBP mRNA

NCBI chr 7:88,862,939...88,945,491
Ensembl chr 7:86,973,069...87,050,827

G

mechanistic target of rapamycin kinase

multiple interactions

bafilomycin A1 inhibits the reaction [Lidocaine results in decreased expression of [MTOR protein binds to RPTOR protein binds to MLST8 protein binds to PRAS40 protein binds to DEPTOR protein]]; dorsomorphin inhibits the reaction [Lidocaine results in decreased expression of [MTOR protein binds to RPTOR protein binds to MLST8 protein binds to PRAS40 protein binds to DEPTOR protein]]; Lidocaine results in decreased expression of [MTOR protein binds to RPTOR protein binds to MLST8 protein binds to PRAS40 protein binds to DEPTOR protein]; MK-8722 promotes the reaction [Lidocaine results in decreased expression of [MTOR protein binds to RPTOR protein binds to MLST8 protein binds to PRAS40 protein binds to DEPTOR protein]]

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311

G

murinoglobulin 2

increases expression

Lidocaine results in increased expression of PZP mRNA

NCBI chr 4:156,836,140...156,908,972
Ensembl chr 4:155,164,011...155,236,475

G

Max dimerization protein 3

increases expression

Lidocaine results in increased expression of MXD3 mRNA

NCBI chr17:9,306,552...9,310,278
Ensembl chr17:9,301,399...9,305,157

G

MYB proto-oncogene like 2

increases expression

Lidocaine results in increased expression of MYBL2 mRNA

NCBI chr 3:172,124,765...172,153,221
Ensembl chr 3:151,705,288...151,733,708

G

myosin binding protein C2

increases expression

Lidocaine results in increased expression of MYBPC2 mRNA

NCBI chr 1:104,130,642...104,154,101
Ensembl chr 1:94,994,104...95,017,584

G

myosin light chain kinase 3

increases expression

Lidocaine results in increased expression of MYLK3 mRNA

NCBI chr19:37,858,298...37,916,805
Ensembl chr19:21,691,929...21,742,954

G

myosin XVIIIb

increases expression

Lidocaine results in increased expression of MYO18B mRNA

NCBI chr12:49,421,062...49,614,127
Ensembl chr12:43,747,010...43,953,695

G

myosin IF

increases expression

Lidocaine results in increased expression of MYO1F mRNA

NCBI chr 7:15,065,530...15,116,087
Ensembl chr 7:14,363,350...14,413,911

G

myosin VIIA

increases expression

Lidocaine results in increased expression of MYO7A mRNA

NCBI chr 1:161,755,110...161,825,397
Ensembl chr 1:152,344,448...152,414,157

G

myelin regulatory factor

multiple interactions
decreases expression

[Antagomirs results in decreased expression of MIR199A2 mRNA] inhibits the reaction [Lidocaine results in decreased expression of MYRF mRNA]; [Antagomirs results in decreased expression of MIR199A2 mRNA] inhibits the reaction [Lidocaine results in decreased expression of MYRF protein]
Lidocaine results in decreased expression of MYRF mRNA; Lidocaine results in decreased expression of MYRF protein

NCBI chr 1:216,279,057...216,311,155
Ensembl chr 1:206,854,175...206,886,157

G

N-acetyl-alpha-glucosaminidase

increases expression

Lidocaine results in increased expression of NAGLU mRNA

NCBI chr10:86,501,864...86,509,333
Ensembl chr10:86,001,566...86,008,972

G

neuron navigator 1

decreases expression

Lidocaine results in decreased expression of NAV1 mRNA

NCBI chr13:49,418,755...49,671,117
Ensembl chr13:46,873,689...47,126,449

G

neurocan

increases expression

Lidocaine results in increased expression of NCAN mRNA

NCBI chr16:19,335,907...19,362,371
Ensembl chr16:19,301,969...19,328,436

G

non-SMC condensin I complex, subunit G

increases expression

Lidocaine results in increased expression of NCAPG mRNA

NCBI chr14:69,616,473...69,645,445
Ensembl chr14:65,404,163...65,432,902

G

non-SMC condensin II complex, subunit G2

increases expression

Lidocaine results in increased expression of NCAPG2 mRNA

NCBI chr 6:143,484,651...143,561,850
Ensembl chr 6:137,342,943...137,415,159

G

non-SMC condensin I complex, subunit H

increases expression

Lidocaine results in increased expression of NCAPH mRNA

NCBI chr 3:134,825,271...134,852,502
Ensembl chr 3:114,371,941...114,399,180

G

neutrophil cytosolic factor 1

increases expression

Lidocaine results in increased expression of NCF1 mRNA

NCBI chr12:28,121,816...28,131,080
Ensembl chr12:22,485,451...22,494,646

G

NCK associated protein 1 like

increases expression

Lidocaine results in increased expression of NCKAP1L mRNA

NCBI chr 7:136,455,900...136,501,384
Ensembl chr 7:134,577,482...134,622,934

G

NDC80 kinetochore complex component

increases expression

Lidocaine results in increased expression of NDC80 mRNA

NCBI chr 9:118,853,806...118,887,582
Ensembl chr 9:111,407,191...111,440,924

G

neurofilament medium chain

multiple interactions
decreases expression

NGF protein inhibits the reaction [Lidocaine results in decreased expression of NEFM protein]; NNAT protein inhibits the reaction [Lidocaine results in decreased expression of NEFM protein]

NCBI chr15:46,535,857...46,541,161
Ensembl chr15:42,360,454...42,365,755

G

nei-like DNA glycosylase 3

increases expression

Lidocaine results in increased expression of NEIL3 mRNA

NCBI chr16:45,091,401...45,151,419
Ensembl chr16:38,359,371...38,418,527

G

NIMA-related kinase 2

increases expression

Lidocaine results in increased expression of NEK2 mRNA

NCBI chr13:105,936,809...105,950,054
Ensembl chr13:103,405,819...103,419,051

G

nestin

increases expression

Lidocaine results in increased expression of NES mRNA

NCBI chr 2:175,735,715...175,745,631
Ensembl chr 2:173,438,734...173,447,777

G

neurofascin

decreases expression

Lidocaine results in decreased expression of NFASC mRNA

NCBI chr13:46,549,369...46,735,989
Ensembl chr13:43,997,224...44,183,880

G

nuclear factor, erythroid 2

decreases expression

Lidocaine results in decreased expression of NFE2 mRNA

NCBI chr 7:136,261,234...136,273,850
Ensembl chr 7:134,382,761...134,390,108

G

NFKB inhibitor delta

increases expression

Lidocaine results in increased expression of NFKBID mRNA

NCBI chr 1:94,808,459...94,824,726
Ensembl chr 1:85,680,861...85,690,447

G

nerve growth factor

decreases expression
multiple interactions

Lidocaine results in decreased expression of NGF protein
NGF protein inhibits the reaction [Lidocaine results in decreased expression of NEFM protein]; NGF protein inhibits the reaction [Lidocaine results in decreased expression of NNAT protein]; NNAT protein inhibits the reaction [Lidocaine results in decreased expression of NGF protein]
NGF protein inhibits the reaction [Lidocaine results in decreased expression of NEFM protein]; NGF protein inhibits the reaction [Lidocaine results in decreased expression of NNAT protein]; NGF protein inhibits the reaction [Lidocaine results in decreased expression of UCHL1 protein]; NNAT protein inhibits the reaction [Lidocaine results in decreased expression of NGF protein]

NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:189,901,058...189,954,452

G

nerve growth factor receptor

increases expression

Lidocaine results in increased expression of NGFR mRNA

NCBI chr10:81,012,077...81,030,305
Ensembl chr10:80,515,299...80,533,518

G

Sodium/potassium transporting ATPase interacting 1

increases expression

Lidocaine results in increased expression of NKAIN1 mRNA

NCBI chr 5:142,747,702...142,792,665
Ensembl chr 5:142,747,505...142,791,863

G

neuronatin

multiple interactions
decreases expression

NGF protein inhibits the reaction [Lidocaine results in decreased expression of NNAT protein]; NNAT protein inhibits the reaction [Lidocaine results in decreased expression of NEFM protein]; NNAT protein inhibits the reaction [Lidocaine results in decreased expression of NGF protein]; NNAT protein inhibits the reaction [Lidocaine results in decreased expression of UCHL1 protein]

NCBI chr 3:166,646,373...166,648,845
Ensembl chr 3:146,226,407...146,228,834

G

nuclear receptor subfamily 1, group I, member 2

increases activity

Lidocaine results in increased activity of NR1I2 protein

NCBI chr11:75,965,717...76,006,733
Ensembl chr11:62,460,213...62,496,658

G

NSL1 component of MIS12 kinetochore complex

increases expression

Lidocaine results in increased expression of NSL1 mRNA

NCBI chr13:105,176,163...105,205,179
Ensembl chr13:102,649,058...102,674,054

G

5'-nucleotidase domain containing 2

increases expression

Lidocaine results in increased expression of NT5DC2 mRNA

NCBI chr16:6,328,925...6,336,978
Ensembl chr16:6,322,236...6,330,537

G

NUF2 component of NDC80 kinetochore complex

increases expression

Lidocaine results in increased expression of NUF2 mRNA

NCBI chr13:84,226,448...84,290,957
Ensembl chr13:81,693,598...81,722,766

G

nucleolar and spindle associated protein 1

increases expression

Lidocaine results in increased expression of NUSAP1 mRNA

NCBI chr 3:127,057,220...127,092,779
Ensembl chr 3:106,603,289...106,633,624

G

2'-5'-oligoadenylate synthetase-like

increases expression

Lidocaine results in increased expression of OASL mRNA

NCBI chr12:47,343,551...47,356,509
Ensembl chr12:41,682,900...41,695,641

G

Opa interacting protein 5

increases expression

Lidocaine results in increased expression of OIP5 mRNA

NCBI chr 3:127,047,559...127,057,043
Ensembl chr 3:106,593,760...106,603,250

G

oxidized low density lipoprotein receptor 1

increases expression

Lidocaine results in increased expression of OLR1 mRNA

NCBI chr 4:164,612,460...164,635,082
Ensembl chr 4:162,926,439...162,948,523

G

5-oxoprolinase (ATP-hydrolysing)

increases expression

Lidocaine results in increased expression of OPLAH mRNA

NCBI chr 7:109,892,136...109,932,403
Ensembl chr 7:108,011,475...108,035,297

G

olfactory receptor family 10 subfamily A member 48B

decreases expression

Lidocaine results in decreased expression of OR10A48 mRNA

NCBI chr 1:172,228,688...172,229,623
Ensembl chr 1:162,793,610...162,797,017

G

olfactory receptor family 1 subfamily O member 2C

decreases expression

Lidocaine results in decreased expression of OR1X2C mRNA

NCBI chr10:35,865,669...35,866,610
Ensembl chr10:35,364,667...35,365,608

G

olfactory receptor family 52 subfamily E member 15C

decreases expression

Lidocaine results in decreased expression of OR52E15C mRNA

NCBI chr 1:168,813,740...168,814,681
Ensembl chr 1:159,401,808...159,408,026

G

olfactory receptor family 6 subfamily K member 2

increases expression

Lidocaine results in increased expression of OR6K2 mRNA

NCBI chr13:88,721,361...88,722,326
Ensembl chr13:86,185,529...86,190,815

G

olfactory receptor family 8 subfamily G member 36B

decreases expression

Lidocaine results in decreased expression of OR8G36B mRNA

NCBI chr 8:48,700,906...48,701,859
Ensembl chr 8:39,803,767...39,804,720

G

origin recognition complex, subunit 1

increases expression

Lidocaine results in increased expression of ORC1 mRNA

NCBI chr 5:128,552,975...128,581,943
Ensembl chr 5:123,324,315...123,348,375

G

orosomucoid 1

affects binding
multiple interactions

Lidocaine binds to ORM1 protein alternative form
Lidocaine inhibits the reaction [Warfarin binds to ORM1 protein alternative form]

NCBI chr 5:81,788,509...81,791,661
Ensembl chr 5:76,772,941...76,776,154

G

OTU deubiquitinase with linear linkage specificity like

increases expression

Lidocaine results in increased expression of FAM105A mRNA

NCBI chr 2:80,136,411...80,164,290
Ensembl chr 2:78,408,593...78,433,838

G

ovochymase 2

decreases expression

Lidocaine results in decreased expression of OVCH2 mRNA

NCBI chr 1:171,105,366...171,125,699
Ensembl chr 1:161,693,647...161,713,952

G

poly (ADP-ribose) polymerase family, member 10

increases expression

Lidocaine results in increased expression of PARP10 mRNA

NCBI chr 7:109,829,721...109,839,054
Ensembl chr 7:107,949,043...107,958,304

G

poly (ADP-ribose) polymerase family, member 14

increases expression

Lidocaine results in increased expression of PARP14 mRNA

NCBI chr11:78,408,134...78,440,201
Ensembl chr11:64,902,785...64,934,916

G

protocadherin related 15

decreases expression

Lidocaine results in decreased expression of PCDH15 mRNA

NCBI chr20:13,996,383...15,495,206
Ensembl chr20:13,963,565...15,494,719

G

protocadherin alpha 12

increases expression

Lidocaine results in increased expression of PCDHA12 mRNA

Ensembl chr18:28,581,225...28,846,211

G

PCNA clamp associated factor

increases expression

Lidocaine results in increased expression of PCLAF mRNA

NCBI chr 8:75,311,028...75,328,108
Ensembl chr 8:66,420,587...66,432,994
Ensembl chr 8:66,420,587...66,432,994

G

programmed cell death 1

increases expression

Lidocaine results in increased expression of PDCD1 mRNA

NCBI chr 9:101,866,124...101,879,278
Ensembl chr 9:94,418,791...94,431,937

G

phosphodiesterase 6B

increases expression

Lidocaine results in increased expression of PDE6B mRNA

NCBI chr14:1,468,302...1,511,435
Ensembl chr14:1,323,310...1,366,450

G

platelet factor 4

increases expression

Lidocaine results in increased expression of PF4 mRNA

NCBI chr14:17,582,477...17,583,392
Ensembl chr14:17,298,308...17,299,365

G

post-GPI attachment to proteins inositol deacylase 1

increases expression

Lidocaine results in increased expression of PGAP1 mRNA

NCBI chr 9:63,470,023...63,538,772
Ensembl chr 9:55,975,667...56,044,464

G

pleckstrin homology-like domain, family B, member 3

increases expression

Lidocaine results in increased expression of PHLDB3 mRNA

NCBI chr 1:89,328,991...89,347,446
Ensembl chr 1:80,201,578...80,219,534

G

peptidase inhibitor 15

decreases expression

Lidocaine results in decreased expression of PI15 mRNA

NCBI chr 5:6,178,427...6,206,548
Ensembl chr 5:1,395,094...1,423,213

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma

increases expression

Lidocaine results in increased expression of PIK3CG mRNA

NCBI chr 6:54,494,247...54,529,563
Ensembl chr 6:48,766,864...48,802,043

G

PICALM interacting mitotic regulator

increases expression

Lidocaine results in increased expression of FAM64A mRNA

NCBI chr10:57,168,136...57,173,713
Ensembl chr10:56,669,675...56,674,791

G

PTEN induced kinase 1

multiple interactions
increases expression

bafilomycin A1 inhibits the reaction [Lidocaine results in increased expression of PINK1 protein]; dorsomorphin inhibits the reaction [Lidocaine results in increased expression of PINK1 protein]; MK-8722 promotes the reaction [Lidocaine results in increased expression of PINK1 protein]

NCBI chr 5:155,813,838...155,825,950
Ensembl chr 5:150,530,523...150,542,635

G

prolactin induced protein

increases expression

Lidocaine results in increased expression of PIP mRNA

NCBI chr 4:71,754,265...71,758,559
Ensembl chr 4:70,787,627...70,791,921

G

phospholipase A2 group IIA

decreases expression

Lidocaine results in decreased expression of PLA2G2A mRNA

NCBI chr 5:156,359,725...156,362,302
Ensembl chr 5:151,076,442...151,079,014

G

placenta associated 8

decreases expression

Lidocaine results in decreased expression of PLAC8 mRNA

NCBI chr14:9,356,950...9,378,586
Ensembl chr14:9,063,048...9,074,264

G

plasminogen activator, urokinase

increases expression

Lidocaine results in increased expression of PLAU mRNA

NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,456,232...3,462,775

G

plasminogen activator, urokinase receptor

increases expression

Lidocaine results in increased expression of PLAUR mRNA

NCBI chr 1:89,181,363...89,196,308
Ensembl chr 1:80,050,324...80,068,595

G

phospholipase B domain containing 1

increases expression

Lidocaine results in increased expression of PLBD1 mRNA

NCBI chr 4:171,204,198...171,260,488
Ensembl chr 4:169,472,983...169,529,277

G

phospholipase C, beta 2

increases expression

Lidocaine results in increased expression of PLCB2 mRNA

NCBI chr 3:126,134,925...126,158,303
Ensembl chr 3:105,684,815...105,704,302

G

phospholipase D family, member 4

increases expression

Lidocaine results in increased expression of PLD4 mRNA

NCBI chr 6:137,639,948...137,647,462
Ensembl chr 6:131,818,860...131,826,376

G

pleckstrin 2

decreases expression

Lidocaine results in decreased expression of PLEK2 mRNA

NCBI chr 6:103,434,156...103,452,457
Ensembl chr 6:97,701,106...97,719,326

G

pleckstrin homology domain containing A2

increases expression

Lidocaine results in increased expression of PLEKHA2 mRNA

NCBI chr16:73,641,338...73,704,068
Ensembl chr16:66,939,109...66,999,395

G

perilipin 2

increases expression

Lidocaine results in increased expression of PLIN2 mRNA

NCBI chr 5:106,202,634...106,258,748
Ensembl chr 5:101,154,411...101,242,319

G

phospholamban

decreases expression

Lidocaine results in decreased expression of PLN mRNA

NCBI chr20:33,166,512...33,182,241

G

proteolipid protein 1

decreases expression
multiple interactions

Lidocaine results in decreased expression of PLP1 mRNA
[Antagomirs results in decreased expression of MIR199A2 mRNA] inhibits the reaction [Lidocaine results in decreased expression of PLP1 mRNA]

NCBI chr X:104,933,921...104,993,317
Ensembl chr X:100,185,767...100,201,032

G

peptidase M20 domain containing 2

increases expression

Lidocaine results in increased expression of PM20D2 mRNA

NCBI chr 5:52,362,384...52,382,647
Ensembl chr 5:47,566,072...47,586,212

G

polyamine-modulated factor 1

increases expression

Lidocaine results in increased expression of PMF1 mRNA

NCBI chr 2:176,145,896...176,166,022
Ensembl chr 2:173,848,074...173,868,270

G

POF1B, actin binding protein

decreases expression

Lidocaine results in decreased expression of POF1B mRNA

NCBI chr X:81,875,348...81,942,046
Ensembl chr X:77,683,128...77,749,688

G

DNA polymerase alpha 1, catalytic subunit

increases expression

Lidocaine results in increased expression of POLA1 mRNA

NCBI chr X:62,028,475...62,342,455
Ensembl chr X:58,034,619...58,348,536

G

DNA polymerase epsilon, catalytic subunit

increases expression

Lidocaine results in increased expression of POLE mRNA

NCBI chr12:52,005,155...52,053,761
Ensembl chr12:46,345,420...46,393,939

G

DNA polymerase epsilon 2, accessory subunit

increases expression

Lidocaine results in increased expression of POLE2 mRNA

NCBI chr 6:93,410,713...93,448,782
Ensembl chr 6:87,674,702...87,699,305

G

DNA polymerase theta

increases expression

Lidocaine results in increased expression of POLQ mRNA

NCBI chr11:77,179,190...77,281,270
Ensembl chr11:63,673,816...63,775,878

G

proopiomelanocortin

multiple interactions

Lidocaine inhibits the reaction [Capsaicin results in increased secretion of POMC protein]

NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:26,939,837...26,945,664

G

periostin

increases expression

Lidocaine results in increased expression of POSTN mRNA

NCBI chr 2:140,677,774...140,709,304
Ensembl chr 2:138,527,696...138,559,099

G

protein phosphatase 4 regulatory subunit 3C

decreases expression

Lidocaine results in decreased expression of PPP4R3C mRNA

NCBI chr X:53,630,250...53,722,658

G

protein regulator of cytokinesis 1

increases expression

Lidocaine results in increased expression of PRC1 mRNA

NCBI chr 1:143,659,312...143,681,019
Ensembl chr 1:134,250,081...134,271,765

G

primase and DNA directed polymerase

increases expression

Lidocaine results in increased expression of PRIMPOL mRNA

NCBI chr16:45,681,252...45,715,758
Ensembl chr16:45,681,326...45,715,565

G

protein kinase AMP-activated catalytic subunit alpha 1

multiple interactions

bafilomycin A1 inhibits the reaction [Lidocaine results in increased phosphorylation of PRKAA1 protein]; dorsomorphin inhibits the reaction [Lidocaine results in increased phosphorylation of PRKAA1 protein]; MK-8722 promotes the reaction [Lidocaine results in increased phosphorylation of PRKAA1 protein]

NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:54,240,137...54,275,978

G

protein kinase C, beta

increases expression
multiple interactions

Lidocaine results in increased expression of PRKCB protein
Dexmedetomidine inhibits the reaction [Lidocaine results in increased expression of PRKCB protein]

NCBI chr 1:186,263,397...186,594,743
Ensembl chr 1:176,832,226...177,163,536

G

protein kinase C, gamma

multiple interactions

Lidocaine inhibits the reaction [remifentanil affects the localization of PRKCG protein]

NCBI chr 1:74,748,272...74,777,611
Ensembl chr 1:65,832,855...65,859,384

G

prokineticin 2

decreases expression

Lidocaine results in decreased expression of PROK2 mRNA

NCBI chr 4:133,903,210...133,918,126
Ensembl chr 4:132,347,103...132,361,385

G

peripherin 2

decreases expression

Lidocaine results in decreased expression of PRPH2 mRNA

NCBI chr 9:21,563,770...21,579,074
Ensembl chr 9:14,066,156...14,081,454

G

proline rich 11

increases expression

Lidocaine results in increased expression of PRR11 mRNA

NCBI chr10:72,396,127...72,440,643
Ensembl chr10:71,901,202...71,921,012

G

proline rich and Gla domain 4

increases expression

Lidocaine results in increased expression of PRRG4 mRNA

NCBI chr 3:111,669,508...111,698,205
Ensembl chr 3:91,214,653...91,243,273

G

serine protease 56

increases expression

Lidocaine results in increased expression of PRSS56 mRNA

NCBI chr 9:95,289,984...95,307,877
Ensembl chr 9:87,854,805...87,859,978

G

prostaglandin E synthase

decreases expression

Lidocaine results in decreased expression of PTGES mRNA

NCBI chr 3:34,575,643...34,586,987

G

prostaglandin-endoperoxide synthase 2

decreases expression

Lidocaine results in decreased expression of PTGS2 mRNA

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine phosphatase, non-receptor type 18

increases expression

Lidocaine results in increased expression of PTPN18 mRNA

NCBI chr 9:44,166,571...44,185,885
Ensembl chr 9:36,672,362...36,690,995

G

protein tyrosine phosphatase, non-receptor type 6

increases expression

Lidocaine results in increased expression of PTPN6 mRNA

NCBI chr 4:159,212,320...159,237,069
Ensembl chr 4:157,526,035...157,550,984

G

PTTG1 regulator of sister chromatid separation, securin

increases expression

Lidocaine results in increased expression of PTTG1 mRNA

NCBI chr10:28,394,940...28,406,410
Ensembl chr10:27,893,689...27,904,837

G

pentraxin 3

decreases expression

Lidocaine results in decreased expression of PTX3 mRNA

NCBI chr 2:152,797,563...152,803,372
Ensembl chr 2:150,487,513...150,493,323

G

PVR cell adhesion molecule

increases expression

Lidocaine results in increased expression of PVR mRNA

NCBI chr 1:88,689,235...88,704,641
Ensembl chr 1:79,546,879...79,576,715

G

Pvt1 oncogene

increases expression

Lidocaine results in increased expression of PVT1 mRNA

NCBI chr 7:95,545,916...95,769,306

G

PYD and CARD domain containing

increases expression

Lidocaine results in increased expression of PYCARD mRNA

NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:182,601,174...182,602,955

G

peptide YY

increases expression

Lidocaine results in increased expression of PYY mRNA

NCBI chr10:87,561,347...87,562,470
Ensembl chr10:87,061,161...87,061,815

G

quinolinate phosphoribosyltransferase

increases expression

Lidocaine results in increased expression of QPRT mRNA

NCBI chr 1:191,148,715...191,164,006
Ensembl chr 1:181,718,190...181,733,486

G

Rab7b, member RAS oncogene family

increases expression

Lidocaine results in increased expression of RAB7B mRNA

NCBI chr13:45,673,396...45,699,798
Ensembl chr13:43,121,226...43,147,581

G

RAB8A, member RAS oncogene family

increases expression

Lidocaine results in increased expression of RAB8A mRNA

NCBI chr16:17,688,049...17,709,412
Ensembl chr16:17,654,034...17,675,678

G

Rac GTPase-activating protein 1

increases expression

Lidocaine results in increased expression of RACGAP1 mRNA

NCBI chr 7:132,629,789...132,659,738
Ensembl chr 7:130,750,936...130,780,831

G

RAD51 recombinase

increases expression

Lidocaine results in increased expression of RAD51 mRNA

NCBI chr 3:126,554,210...126,578,888
Ensembl chr 3:106,100,381...106,125,035

G

RAD54 like

increases expression

Lidocaine results in increased expression of RAD54L mRNA

NCBI chr 5:134,812,158...134,841,821
Ensembl chr 5:129,575,378...129,605,070

G

RAS p21 protein activator 4

increases expression

Lidocaine results in increased expression of RASA4 mRNA

NCBI chr12:26,189,416...26,216,801
Ensembl chr12:20,552,806...20,580,147

G

RB transcriptional corepressor like 1

affects expression
increases expression

Lidocaine affects the expression of RBL1 mRNA
Lidocaine results in increased expression of RBL1 mRNA

PMID:18931217 PMID:35283115

NCBI chr 3:166,226,187...166,289,862
Ensembl chr 3:145,807,095...145,869,330

G

RB transcriptional corepressor like 2

affects expression

Lidocaine affects the expression of RBL2 mRNA

NCBI chr19:32,049,690...32,096,467
Ensembl chr19:15,876,853...15,923,572

G

RNA binding motif protein 47

increases expression

Lidocaine results in increased expression of RBM47 mRNA

NCBI chr14:42,407,226...42,545,304
Ensembl chr14:42,154,142...42,189,431

G

RecQ like helicase 4

increases expression

Lidocaine results in increased expression of RECQL4 mRNA

NCBI chr 7:110,304,092...110,311,426
Ensembl chr 7:108,423,455...108,430,619

G

regenerating family member 3 beta

increases expression

Lidocaine results in increased expression of REG3B mRNA

NCBI chr 4:112,419,776...112,423,014
Ensembl chr 4:110,861,775...110,865,015

G

similar to ATPase inhibitory factor 1

decreases expression

Lidocaine results in decreased expression of RGD1559545 mRNA

NCBI chr 6:89,821,916...89,842,882

G

similar to nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

increases expression

Lidocaine results in increased expression of RGD1560225 mRNA

G

regulator of G-protein signaling 18

increases expression

Lidocaine results in increased expression of RGS18 mRNA

NCBI chr13:59,043,431...59,066,342
Ensembl chr13:56,494,010...56,516,098

G

28S ribosomal RNA

decreases expression

Lidocaine results in decreased expression of RN28S mRNA

G

regulatory associated protein of MTOR, complex 1

multiple interactions

bafilomycin A1 inhibits the reaction [Lidocaine results in decreased expression of [MTOR protein binds to RPTOR protein binds to MLST8 protein binds to PRAS40 protein binds to DEPTOR protein]]; dorsomorphin inhibits the reaction [Lidocaine results in decreased expression of [MTOR protein binds to RPTOR protein binds to MLST8 protein binds to PRAS40 protein binds to DEPTOR protein]]; Lidocaine results in decreased expression of [MTOR protein binds to RPTOR protein binds to MLST8 protein binds to PRAS40 protein binds to DEPTOR protein]; MK-8722 promotes the reaction [Lidocaine results in decreased expression of [MTOR protein binds to RPTOR protein binds to MLST8 protein binds to PRAS40 protein binds to DEPTOR protein]]

NCBI chr10:105,376,943...105,675,416
Ensembl chr10:104,878,487...105,176,983

G

ribonucleotide reductase catalytic subunit M1

increases expression

Lidocaine results in increased expression of RRM1 mRNA

NCBI chr 1:166,235,904...166,260,206
Ensembl chr 1:156,823,960...156,848,261

G

ribonucleotide reductase regulatory subunit M2

increases expression

Lidocaine results in increased expression of RRM2 mRNA

NCBI chr 6:47,044,755...47,075,370
Ensembl chr 6:41,340,557...41,346,773

G

radical S-adenosyl methionine domain containing 2

increases expression

Lidocaine results in increased expression of RSAD2 mRNA

NCBI chr 6:48,774,985...48,788,245
Ensembl chr 6:43,047,658...43,059,699

G

RT1 class I, locus CE10

decreases expression

Lidocaine results in decreased expression of RT1-CE10 mRNA

NCBI chr20:3,381,377...3,385,052

G

RT1 class I, locus CE2

decreases expression

Lidocaine results in decreased expression of RT1-CE2 mRNA

NCBI chr20:3,542,984...3,546,753
Ensembl chr20:3,537,809...3,541,790

G

RT1 class I, locus CE5

decreases expression

Lidocaine results in decreased expression of RT1-CE5 mRNA

NCBI chr20:3,407,880...3,484,130

G

RT1 class II, locus DMb

increases expression

Lidocaine results in increased expression of RT1-DMB mRNA

NCBI chr20:4,695,009...4,702,560
Ensembl chr20:4,693,103...4,700,340

G

RT1 class Ib, locus N2

increases expression

Lidocaine results in increased expression of RT1-N2 mRNA

NCBI chr20:2,645,980...2,650,260
Ensembl chr20:2,641,202...2,644,900

G

RT1 class I, locus T24, gene 3

increases expression

Lidocaine results in increased expression of RT1-T24-3 mRNA

NCBI chr20:2,723,043...2,752,691
Ensembl chr20:2,718,279...2,776,154

G

S100 calcium binding protein A11

increases expression

Lidocaine results in increased expression of S100A11 mRNA

NCBI chr 2:181,875,132...181,880,542
Ensembl chr 2:179,191,715...179,197,044

G

S100 calcium binding protein A3

increases expression

Lidocaine results in increased expression of S100A3 mRNA

NCBI chr 2:178,331,856...178,387,280
Ensembl chr 2:176,049,520...176,089,702

G

S100 calcium binding protein A8

increases expression
decreases expression

Lidocaine results in increased expression of S100A8 protein
Lidocaine results in decreased expression of S100A8 mRNA

PMID:18382663 PMID:35283115

NCBI chr 2:178,464,095...178,465,223
Ensembl chr 2:176,167,124...176,167,643

G

S100 calcium binding protein A9

increases expression

Lidocaine results in increased expression of S100A9 protein

NCBI chr 2:178,487,941...178,490,622
Ensembl chr 2:176,190,361...176,193,230

G

suppressor APC domain containing 2

increases expression

Lidocaine results in increased expression of SAPCD2 mRNA

NCBI chr 3:28,583,615...28,590,694
Ensembl chr 3:8,187,266...8,192,546

G

sterol-C5-desaturase

decreases expression

Lidocaine results in decreased expression of SC5D mRNA

NCBI chr 8:51,526,669...51,538,277
Ensembl chr 8:42,632,672...42,641,273

G

secretoglobin family 1A member 1

increases expression

Lidocaine results in increased expression of SCGB1A1 mRNA

NCBI chr 1:215,406,138...215,409,686
Ensembl chr 1:205,977,060...205,980,610

G

sodium voltage-gated channel alpha subunit 4

multiple interactions

Lidocaine binds to and results in decreased activity of SCN4A protein

NCBI chr10:91,745,459...91,796,452
Ensembl chr10:91,246,936...91,296,545

G

sodium voltage-gated channel alpha subunit 5

affects response to substance

SCN5A protein mutant form affects the susceptibility to Lidocaine

NCBI chr 8:128,098,613...128,196,515
Ensembl chr 8:119,220,905...119,318,769

G

secretin

increases expression

Lidocaine results in increased expression of SCT mRNA

NCBI chr 1:205,812,435...205,813,246
Ensembl chr 1:196,382,856...196,383,658

G

signal peptide, CUB domain and EGF like domain containing 1

increases expression

Lidocaine results in increased expression of SCUBE1 mRNA

NCBI chr 7:116,639,027...116,760,986
Ensembl chr 7:114,759,010...114,880,940

G

stromal cell-derived factor 2-like 1

increases expression

Lidocaine results in increased expression of SDF2L1 mRNA

NCBI chr11:97,376,878...97,379,120
Ensembl chr11:83,872,659...83,874,902

G

selectin L

multiple interactions

Lidocaine inhibits the reaction [TNF protein results in increased cleavage of SELL protein]

NCBI chr13:78,950,100...78,969,604
Ensembl chr13:76,416,915...76,436,456

G

semaphorin 5B

increases expression

Lidocaine results in increased expression of SEMA5B mRNA

NCBI chr11:78,607,805...78,730,724
Ensembl chr11:65,102,031...65,225,311

G

shugoshin 2

increases expression

Lidocaine results in increased expression of SGO2 mRNA

NCBI chr 9:67,032,083...67,067,439
Ensembl chr 9:59,548,683...59,573,229

G

small G protein signaling modulator 3

decreases expression

Lidocaine results in decreased expression of SGSM3 mRNA

NCBI chr 7:114,394,724...114,424,285
Ensembl chr 7:112,514,630...112,544,108

G

SHC adaptor protein 4

increases expression

Lidocaine results in increased expression of SHC4 mRNA

NCBI chr 3:133,334,026...133,428,404
Ensembl chr 3:112,880,600...112,974,366

G

SHC binding and spindle associated 1

increases expression

Lidocaine results in increased expression of SHCBP1 mRNA

NCBI chr16:91,373,843...91,405,409
Ensembl chr16:84,672,321...84,703,844

G

serine hydroxymethyltransferase 1

increases expression

Lidocaine results in increased expression of SHMT1 mRNA

NCBI chr10:45,968,959...45,990,341
Ensembl chr10:45,468,700...45,497,820

G

sirtuin 1

decreases expression
multiple interactions

Lidocaine results in decreased expression of SIRT1 protein
Bortezomib inhibits the reaction [Lidocaine results in decreased expression of SIRT1 protein]; Dexmedetomidine inhibits the reaction [Lidocaine results in decreased expression of SIRT1 protein]; SIRT1 protein inhibits the reaction [Lidocaine results in decreased expression of BCL2 protein]; SIRT1 protein inhibits the reaction [Lidocaine results in increased expression of BAX protein]; SIRT1 protein inhibits the reaction [Lidocaine results in increased expression of FOXO3 protein]

NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260

G

sirtuin 4

decreases expression

Lidocaine results in decreased expression of SIRT4 mRNA

NCBI chr12:46,785,852...46,800,179
Ensembl chr12:41,131,262...41,139,439

G

spindle and kinetochore associated complex subunit 1

increases expression

Lidocaine results in increased expression of SKA1 mRNA

NCBI chr18:70,069,957...70,080,303
Ensembl chr18:67,794,725...67,805,037

G

spindle and kinetochore associated complex subunit 3

increases expression

Lidocaine results in increased expression of SKA3 mRNA

NCBI chr15:36,067,372...36,086,563
Ensembl chr15:31,951,825...31,971,010

G

SLAM family member 7

increases expression

Lidocaine results in increased expression of SLAMF7 mRNA

NCBI chr13:86,668,060...86,688,222
Ensembl chr13:84,136,899...84,154,105

G

SLAM family member 9

increases expression

Lidocaine results in increased expression of SLAMF9 mRNA

NCBI chr13:87,474,290...87,477,108
Ensembl chr13:84,941,982...84,944,748

G

solute carrier family 10 member 6

increases expression

Lidocaine results in increased expression of SLC10A6 mRNA

NCBI chr14:6,385,348...6,407,532
Ensembl chr14:6,080,717...6,103,037

G

solute carrier family 13 member 3

decreases expression

Lidocaine results in decreased expression of SLC13A3 mRNA

NCBI chr 3:174,561,174...174,623,893
Ensembl chr 3:154,141,872...154,204,606

G

solute carrier family 22 member 1

multiple interactions

Lidocaine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:48,076,666...48,103,678

G

solute carrier family 22 member 16

multiple interactions

Lidocaine inhibits the reaction [SLC22A16 protein results in increased uptake of Tetraethylammonium]

NCBI chr20:45,527,275...45,647,675
Ensembl chr20:43,972,836...44,065,019

G

solute carrier family 22 member 2

multiple interactions

Lidocaine inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 22 member 3

multiple interactions

Lidocaine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr 1:50,783,218...50,872,358
Ensembl chr 1:48,235,476...48,324,612

G

solute carrier family 22 member 4

multiple interactions

Lidocaine inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]

NCBI chr10:38,634,098...38,687,409
Ensembl chr10:38,133,322...38,179,720

G

solute carrier family 22 member 5

multiple interactions

Lidocaine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]

NCBI chr10:38,509,072...38,536,240
Ensembl chr10:38,008,311...38,035,309

G

solute carrier family 26 member 2

decreases expression

Lidocaine results in decreased expression of SLC26A2 mRNA

NCBI chr18:56,918,662...56,937,032
Ensembl chr18:54,652,951...54,666,626

G

solute carrier family 28 member 1

decreases expression

Lidocaine results in decreased expression of SLC28A1 mRNA

NCBI chr 1:144,490,453...144,532,025
Ensembl chr 1:135,081,385...135,122,464

G

solute carrier family 39 member 12

increases expression

Lidocaine results in increased expression of SLC39A12 mRNA

NCBI chr17:82,262,303...82,348,974
Ensembl chr17:77,353,805...77,440,353

G

solute carrier family 41 member 2

decreases expression

Lidocaine results in decreased expression of SLC41A2 mRNA

NCBI chr 7:22,271,298...22,378,764
Ensembl chr 7:20,383,757...20,491,166

G

solute carrier family 6 member 2

multiple interactions

Lidocaine inhibits the reaction [[Desipramine results in decreased activity of SLC6A2 protein] which results in decreased abundance of Norepinephrine]

NCBI chr19:30,183,289...30,228,292
Ensembl chr19:14,010,386...14,050,357

G

solute carrier family 7 member 7

increases expression

Lidocaine results in increased expression of SLC7A7 mRNA

NCBI chr15:31,792,122...31,852,732
Ensembl chr15:27,822,091...27,865,648

G

solute carrier organic anion transporter family, member 2b1

increases expression

Lidocaine results in increased expression of SLCO2B1 mRNA

NCBI chr 1:163,371,410...163,419,412
Ensembl chr 1:153,959,293...154,007,353

G

structural maintenance of chromosomes 2

increases expression

Lidocaine results in increased expression of SMC2 mRNA

NCBI chr 5:71,592,428...71,648,636
Ensembl chr 5:66,807,011...66,853,242

G

sorting nexin 20

increases expression

Lidocaine results in increased expression of SNX20 mRNA

NCBI chr19:18,435,935...18,445,108
Ensembl chr19:18,435,935...18,445,107

G

sterol O-acyltransferase 1

increases expression

Lidocaine results in increased expression of SOAT1 mRNA

NCBI chr13:71,105,178...71,147,776
Ensembl chr13:68,552,317...68,597,494

G

SPC24 component of NDC80 kinetochore complex

increases expression

Lidocaine results in increased expression of SPC24 mRNA

NCBI chr 8:28,576,409...28,581,481
Ensembl chr 8:20,300,319...20,305,310

G

SPC25 component of NDC80 kinetochore complex

increases expression

Lidocaine results in increased expression of SPC25 mRNA

NCBI chr 3:74,337,872...74,396,825
Ensembl chr 3:53,975,704...53,988,959

G

Spi-1 proto-oncogene

increases expression

Lidocaine results in increased expression of SPI1 mRNA

NCBI chr 3:97,529,509...97,548,204
Ensembl chr 3:77,073,012...77,092,393

G

serine peptidase inhibitor, Kazal type 2

increases expression

Lidocaine results in increased expression of SPINK2 mRNA

NCBI chr14:31,321,976...31,328,622
Ensembl chr14:30,967,714...30,974,326

G

secreted phosphoprotein 1

increases expression

Lidocaine results in increased expression of SPP1 mRNA

NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,308,885...5,315,162

G

steroid 5 alpha-reductase 2

decreases expression

Lidocaine results in decreased expression of SRD5A2 mRNA

NCBI chr 6:27,178,089...27,217,588
Ensembl chr 6:21,426,215...21,462,112

G

ST14 transmembrane serine protease matriptase

increases expression

Lidocaine results in increased expression of ST14 mRNA

NCBI chr 8:37,798,994...37,839,881
Ensembl chr 8:29,540,811...29,581,517

G

signal transducing adaptor family member 1

increases expression

Lidocaine results in increased expression of STAP1 mRNA

NCBI chr14:22,301,278...22,336,218
Ensembl chr14:21,952,496...21,981,245

G

signal transducer and activator of transcription 6

increases expression

Lidocaine results in increased expression of STAT6 mRNA

NCBI chr 7:65,365,505...65,382,825
Ensembl chr 7:63,479,642...63,498,495

G

STEAP4 metalloreductase

decreases expression

Lidocaine results in decreased expression of STEAP4 mRNA

NCBI chr 4:27,032,096...27,054,769
Ensembl chr 4:26,054,671...26,099,859

G

stefin A2-like 3

decreases expression

Lidocaine results in decreased expression of STFA2L3 mRNA

NCBI chr11:78,093,735...78,098,750
Ensembl chr11:64,588,465...64,593,327

G

stefin A3-like 1

decreases expression

Lidocaine results in decreased expression of STFA3L1 mRNA

NCBI chr11:78,114,013...78,121,232
Ensembl chr11:64,608,683...64,615,902

G

STIL, centriolar assembly protein

increases expression

Lidocaine results in increased expression of STIL mRNA

NCBI chr 5:133,757,598...133,810,493
Ensembl chr 5:128,520,953...128,573,730

G

serine/threonine kinase-like domain containing 1

decreases expression

Lidocaine results in decreased expression of STKLD1 mRNA

NCBI chr 3:30,659,659...30,678,650
Ensembl chr 3:10,261,828...10,280,566

G

stathmin 1

increases expression

Lidocaine results in increased expression of STMN1 mRNA; Lidocaine results in increased expression of STMN1 protein

NCBI chr 5:151,964,308...151,970,843
Ensembl chr 5:146,681,436...146,687,154

G

syntaxin binding protein 2

increases expression

Lidocaine results in increased expression of STXBP2 mRNA

NCBI chr12:6,487,265...6,498,351
Ensembl chr12:1,689,410...1,700,458

G

sulfotransferase family 1A member 1

increases sulfation

SULT1A1 protein results in increased sulfation of Lidocaine metabolite

NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:181,272,023...181,275,562

G

sulfotransferase family 1B member 1

increases sulfation

SULT1B1 protein results in increased sulfation of Lidocaine metabolite

NCBI chr14:20,771,917...20,784,665
Ensembl chr14:20,492,708...20,505,483

G

spleen associated tyrosine kinase

increases expression

Lidocaine results in increased expression of SYK mRNA

NCBI chr17:12,756,493...12,830,927
Ensembl chr17:12,604,619...12,661,410

G

synaptophysin-like 2

increases expression

Lidocaine results in increased expression of SYPL2 mRNA

NCBI chr 2:198,537,208...198,551,939
Ensembl chr 2:195,849,062...195,863,794

G

tachykinin, precursor 1

increases expression

Lidocaine results in increased expression of TAC1 mRNA

NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:35,679,704...35,687,178

G

transforming, acidic coiled-coil containing protein 3

increases expression

Lidocaine results in increased expression of TACC3 mRNA

NCBI chr14:81,275,755...81,289,894
Ensembl chr14:77,051,215...77,065,219

G

T-cell activation RhoGTPase activating protein

increases expression

Lidocaine results in increased expression of TAGAP mRNA

NCBI chr 1:49,575,750...49,584,747
Ensembl chr 1:47,170,725...47,179,792

G

transcription factor 19

increases expression

Lidocaine results in increased expression of TCF19 mRNA

NCBI chr20:3,223,464...3,227,569
Ensembl chr20:3,218,693...3,223,271

G

trichohyalin-like 1

decreases expression

Lidocaine results in decreased expression of TCHHL1 mRNA

NCBI chr 2:179,134,941...179,138,467
Ensembl chr 2:179,135,796...179,138,202

G

transcriptional and immune response regulator

increases expression

Lidocaine results in increased expression of TCIM mRNA

NCBI chr16:74,298,344...74,299,637
Ensembl chr16:67,593,410...67,597,581

G

tec protein tyrosine kinase

increases expression

Lidocaine results in increased expression of TEC mRNA

NCBI chr14:35,706,557...35,815,563
Ensembl chr14:35,352,829...35,461,557

G

terminal nucleotidyltransferase 5A

increases expression

Lidocaine results in increased expression of FAM46A mRNA

NCBI chr 8:95,102,349...95,109,100
Ensembl chr 8:86,225,357...86,229,045

G

terminal nucleotidyltransferase 5C

increases expression

Lidocaine results in increased expression of FAM46C mRNA

NCBI chr 2:190,541,668...190,563,902
Ensembl chr 2:187,853,024...187,894,744

G

testis expressed 56

increases expression

Lidocaine results in increased expression of TEX56P mRNA

NCBI chr17:29,929,855...29,966,578
Ensembl chr17:29,929,780...29,966,579

G

trefoil factor 3

increases expression

Lidocaine results in increased expression of TFF3 mRNA

NCBI chr20:9,194,623...9,199,333
Ensembl chr20:9,193,262...9,198,054

G

transforming growth factor alpha

decreases expression

Lidocaine results in decreased expression of TGFA protein

NCBI chr 4:120,175,549...120,258,342
Ensembl chr 4:118,618,269...118,700,894

G

transforming growth factor, beta 1

increases expression

Lidocaine results in increased expression of TGFB1 mRNA

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847

G

TGFB-induced factor homeobox 2

increases expression

Lidocaine results in increased expression of TGIF2 mRNA

NCBI chr 3:165,791,101...165,808,669
Ensembl chr 3:145,333,418...145,348,596
Ensembl chr17:145,333,418...145,348,596

G

thrombospondin 2

increases expression

Lidocaine results in increased expression of THBS2 mRNA

NCBI chr 1:64,343,523...64,372,918
Ensembl chr 1:55,670,394...55,699,789

G

thrombospondin 4

increases expression

Lidocaine results in increased expression of THBS4 mRNA

NCBI chr 2:25,718,219...25,760,345
Ensembl chr 2:23,983,158...24,026,313

G

TIR domain containing adaptor molecule 2

increases expression

Lidocaine results in increased expression of TICAM2 mRNA

NCBI chr18:41,481,057...41,498,065
Ensembl chr18:39,294,453...39,311,462

G

TOPBP1-interacting checkpoint and replication regulator

increases expression

Lidocaine results in increased expression of TICRR mRNA

NCBI chr 1:143,006,989...143,048,836
Ensembl chr 1:133,597,716...133,639,523

G

TIFA inhibitor

increases expression

Lidocaine results in increased expression of TIFAB mRNA

NCBI chr17:8,438,622...8,441,750
Ensembl chr17:8,431,635...8,436,592

G

T-cell immunoglobulin and mucin domain containing 2

increases expression

Lidocaine results in increased expression of TIMD2 mRNA

NCBI chr10:31,561,563...31,602,515
Ensembl chr10:31,060,326...31,094,623

G

thymidine kinase 1

increases expression

Lidocaine results in increased expression of TK1 mRNA

NCBI chr10:103,533,449...103,544,818
Ensembl chr10:103,031,521...103,046,920

G

talin 1

increases expression

Lidocaine results in increased expression of TLN1 mRNA

NCBI chr 5:62,583,730...62,613,687
Ensembl chr 5:57,787,943...57,817,900

G

toll-like receptor 3

increases expression

Lidocaine results in increased expression of TLR3 mRNA

NCBI chr16:53,554,916...53,572,321
Ensembl chr16:46,822,039...46,836,545

G

toll-like receptor 4

increases expression

Lidocaine results in increased expression of TLR4 mRNA

NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628

G

toll-like receptor 8

increases expression

Lidocaine results in increased expression of TLR8 mRNA

NCBI chr X:30,708,714...30,733,104
Ensembl chr X:27,091,778...27,116,549

G

toll-like receptor 9

increases expression

Lidocaine results in increased expression of TLR9 mRNA

NCBI chr 8:115,743,407...115,747,523
Ensembl chr 8:106,864,680...106,868,796

G

transmembrane protein 119

increases expression

Lidocaine results in increased expression of TMEM119 mRNA

NCBI chr12:48,489,157...48,496,214
Ensembl chr12:42,828,418...42,835,689

G

transmembrane protein 176B

increases expression

Lidocaine results in increased expression of TMEM176B mRNA

NCBI chr 4:79,097,808...79,105,263
Ensembl chr 4:77,766,928...77,774,384

G

transmembrane serine protease 7

decreases expression

Lidocaine results in decreased expression of TMPRSS7 mRNA

NCBI chr11:68,583,710...68,629,200
Ensembl chr11:55,128,998...55,164,882

G

transmembrane serine protease 9

increases expression

Lidocaine results in increased expression of TMPRSS9 mRNA

NCBI chr 7:9,460,998...9,481,854
Ensembl chr 7:8,810,320...8,831,177

G

tenascin C

increases expression

Lidocaine results in increased expression of TNC mRNA

NCBI chr 5:82,391,340...82,476,197
Ensembl chr 5:77,375,851...77,460,624

G

tumor necrosis factor

multiple interactions

Lidocaine inhibits the reaction [TNF protein results in increased cleavage of SELL protein]; Lidocaine inhibits the reaction [TNF protein results in increased expression of [ITGAM protein binds to ITGB2 protein]]
Lidocaine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; Lidocaine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]

PMID:9336308 PMID:32471037

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629

G

TNF alpha induced protein 8 like 2

increases expression

Lidocaine results in increased expression of TNFAIP8L2 mRNA

NCBI chr 2:185,399,442...185,415,798
Ensembl chr 2:182,709,378...182,726,760

G

TNF receptor superfamily member 12A

increases expression

Lidocaine results in increased expression of TNFRSF12A mRNA

NCBI chr10:13,211,670...13,213,666
Ensembl chr10:12,689,890...12,709,045

G

troponin I2, fast skeletal type

increases expression

Lidocaine results in increased expression of TNNI2 mRNA

NCBI chr 1:206,882,358...207,027,034
Ensembl chr 1:197,594,813...197,597,560

G

TOP6B like initiator of meiotic double strand breaks

decreases expression

Lidocaine results in decreased expression of TOP6BL mRNA

NCBI chr 1:211,331,973...211,419,015

G

tumor protein p53

affects expression
decreases expression

Lidocaine affects the expression of TRP53 mRNA
Lidocaine results in decreased expression of TP53 mRNA

PMID:18931217 PMID:35283115

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524

G

trophoblast glycoprotein-like

increases expression

Lidocaine results in increased expression of TPBGL mRNA

NCBI chr 1:163,335,851...163,338,677
Ensembl chr 1:153,925,098...153,926,252

G

tryptophan hydroxylase 1

increases expression

Lidocaine results in increased expression of TPH1 mRNA

NCBI chr 1:106,293,695...106,314,628
Ensembl chr 1:97,157,409...97,178,344

G

TPX2, microtubule nucleation factor

increases expression

Lidocaine results in increased expression of TPX2 mRNA

NCBI chr 3:161,778,709...161,820,941
Ensembl chr 3:141,318,455...141,360,468

G

TRAF-interacting protein

increases expression

Lidocaine results in increased expression of TRAIP mRNA

NCBI chr 8:117,520,476...117,540,253
Ensembl chr 8:108,641,852...108,661,638

G

translocation associated membrane protein 2

increases expression

Lidocaine results in increased expression of TRAM2 mRNA

NCBI chr 9:30,915,624...30,995,162
Ensembl chr 9:23,424,232...23,498,689

G

T cell receptor alpha variable 12-3

decreases expression

Lidocaine results in decreased expression of TRAV12-3 mRNA

NCBI chr15:25,503,871...25,504,883
Ensembl chr15:25,503,985...25,504,565

G

tripartite motif-containing 7

decreases expression

Lidocaine results in decreased expression of TRIM7 mRNA

NCBI chr10:33,706,614...33,722,609
Ensembl chr10:33,205,491...33,221,468

G

thyroid hormone receptor interactor 13

increases expression

Lidocaine results in increased expression of TRIP13 mRNA

NCBI chr 1:31,185,700...31,230,638
Ensembl chr 1:29,357,130...29,402,074

G

trophinin associated protein

increases expression

Lidocaine results in increased expression of TROAP mRNA

NCBI chr 7:132,111,892...132,121,296
Ensembl chr 7:130,234,544...130,242,365

G

transient receptor potential cation channel, subfamily A, member 1

increases activity

Lidocaine results in increased activity of TRPA1 protein

NCBI chr 5:9,163,060...9,217,325
Ensembl chr 5:4,379,999...4,433,570

G

transient receptor potential cation channel, subfamily V, member 1

increases activity
multiple interactions

Lidocaine results in increased activity of TRPV1 protein
TRPV1 protein affects the reaction [Lidocaine results in increased secretion of CALCA protein]
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Lidocaine results in increased activity of TRPV1 protein]; capsazepine inhibits the reaction [Lidocaine results in increased activity of TRPV1 protein]; Lidocaine promotes the reaction [Camphor results in increased activity of TRPV1 protein]; Lidocaine promotes the reaction [Capsaicin results in increased activity of TRPV1 protein]; Lidocaine promotes the reaction [TRPV1 protein results in increased abundance of Calcium]; N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [Lidocaine results in increased activity of TRPV1 protein]; oxophenylarsine inhibits the reaction [Lidocaine promotes the reaction [Capsaicin results in increased activity of TRPV1 protein]]; oxophenylarsine inhibits the reaction [Lidocaine results in increased activity of TRPV1 protein]; Ruthenium Red inhibits the reaction [Lidocaine results in increased activity of TRPV1 protein]; Tetradecanoylphorbol Acetate promotes the reaction [Lidocaine results in increased activity of TRPV1 protein]

NCBI chr10:58,349,936...58,375,021
Ensembl chr10:57,851,428...57,876,513

G

Ttk protein kinase

increases expression

Lidocaine results in increased expression of TTK mRNA

NCBI chr 8:93,632,678...93,672,664
Ensembl chr 8:84,754,315...84,792,651

G

thymidylate synthetase

increases expression

Lidocaine results in increased expression of TYMS mRNA

NCBI chr 9:120,760,057...120,776,149
Ensembl chr 9:113,313,452...113,329,536

G

transmembrane immune signaling adaptor Tyrobp

increases expression

Lidocaine results in increased expression of TYROBP mRNA

NCBI chr 1:94,800,372...94,804,307
Ensembl chr 1:85,672,994...85,676,848

G

ubiquitin D

decreases expression

Lidocaine results in decreased expression of UBD mRNA

NCBI chr20:1,390,734...1,392,685
Ensembl chr20:1,385,864...1,408,639
Ensembl chr20:1,385,864...1,408,639

G

ubiquitin-conjugating enzyme E2C

increases expression

Lidocaine results in increased expression of UBE2C mRNA

NCBI chr 3:173,925,975...173,928,375
Ensembl chr 3:153,506,636...153,513,339

G

ubiquitin-conjugating enzyme E2T

increases expression

Lidocaine results in increased expression of UBE2T mRNA

NCBI chr13:48,955,166...48,965,668
Ensembl chr13:46,403,375...46,414,835

G

ubiquitin-like 7

decreases expression

Lidocaine results in decreased expression of UBL7 protein

NCBI chr 8:67,217,151...67,236,224
Ensembl chr 8:58,320,866...58,340,344

G

ubiquitin C-terminal hydrolase L1

multiple interactions
decreases expression

NGF protein inhibits the reaction [Lidocaine results in decreased expression of UCHL1 protein]; NNAT protein inhibits the reaction [Lidocaine results in decreased expression of UCHL1 protein]

NCBI chr14:41,838,859...41,849,743
Ensembl chr14:41,485,031...41,495,590

G

urocortin

increases expression

Lidocaine results in increased expression of UCN mRNA

NCBI chr 6:30,958,086...30,958,916
Ensembl chr 6:25,238,120...25,238,950

G

uncoupling protein 2

increases expression

Lidocaine results in increased expression of UCP2 mRNA

NCBI chr 1:164,251,373...164,257,742
Ensembl chr 1:154,839,209...154,845,611

G

unc-5 family C-terminal like

increases expression

Lidocaine results in increased expression of UNC5CL mRNA

NCBI chr 9:20,025,719...20,041,083
Ensembl chr 9:12,528,246...12,542,233

G

unc-93 homolog B1, TLR signaling regulator

increases expression

Lidocaine results in increased expression of UNC93B1 mRNA

NCBI chr 1:210,596,639...210,607,579
Ensembl chr 1:201,152,693...201,178,338

G

ubiquitin specific peptidase 18

increases expression

Lidocaine results in increased expression of USP18 mRNA

NCBI chr 4:156,143,770...156,171,292
Ensembl chr 4:154,471,592...154,499,144

G

urotensin 2

increases expression

Lidocaine results in increased expression of UTS2 mRNA

NCBI chr 5:166,725,471...166,739,063
Ensembl chr 5:161,450,846...161,456,237

G

vav guanine nucleotide exchange factor 1

increases expression

Lidocaine results in increased expression of VAV1 mRNA

NCBI chr 9:2,248,856...2,295,905
Ensembl chr 9:2,157,900...2,208,937

G

versican

increases expression

Lidocaine results in increased expression of VCAN mRNA

NCBI chr 2:22,497,035...22,595,955
Ensembl chr 2:20,761,718...20,860,637

G

VGF nerve growth factor inducible

increases expression

Lidocaine results in increased expression of VGF mRNA

NCBI chr12:25,274,004...25,281,803
Ensembl chr12:19,637,320...19,640,341

G

von Willebrand factor A domain containing 5A like 1

decreases expression

Lidocaine results in decreased expression of VWA5AL1 mRNA

NCBI chr 8:39,869,937...39,890,669
Ensembl chr 8:39,870,563...39,893,187

G

WDFY family member 4

increases expression

Lidocaine results in increased expression of WDFY4 mRNA

NCBI chr16:8,228,147...8,456,777
Ensembl chr16:8,221,719...8,450,491

G

Z-DNA binding protein 1

increases expression

Lidocaine results in increased expression of ZBP1 mRNA

NCBI chr 3:182,411,665...182,427,604
Ensembl chr 3:161,993,351...162,003,870

G

zinc finger CCCH-type containing, antiviral 1

increases expression

Lidocaine results in increased expression of ZC3HAV1 mRNA

NCBI chr 4:67,979,055...68,029,353
Ensembl chr 4:67,012,185...67,062,428

G

zinc finger protein 281

decreases expression

Lidocaine results in decreased expression of ZFP281 mRNA

NCBI chr13:50,647,750...50,655,912
Ensembl chr13:48,037,286...48,104,888

G

zinc finger protein 597

decreases expression

Lidocaine results in decreased expression of ZFP597 mRNA

NCBI chr10:12,159,533...12,165,207
Ensembl chr10:11,653,127...11,660,675

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19887
role	19858
biological role	19856
xenobiotic	18730
lidocaine	647
lidocaine hydrochloride +	0
Path 2
Term	Annotations
CHEBI ontology	19887
subatomic particle	19885
composite particle	19885
hadron	19885
baryon	19885
nucleon	19885
atomic nucleus	19885
atom	19885
main group element atom	19824
main group molecular entity	19824
s-block molecular entity	19658
hydrogen molecular entity	19640
hydrides	19145
inorganic hydride	18162
pnictogen hydride	18152
nitrogen hydride	18059
azane	17869
ammonia	17868
organic amino compound	17868
amino acid	16061
alpha-amino acid	13936
serine family amino acid	5765
glycine	3329
glycine derivative	3317
glycinamide	649
lidocaine	647
lidocaine hydrochloride +	0

paths to the root