 Gene-Chemical Interaction Annotations | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations |
Welcome {{ username}}
Message Center
{{ messageCount }} Messages
Watched Genes
{{$index + 1}}. {{ watchedObject.symbol }} (RGD ID:{{watchedObject.rgdId}})
Watched Ontology Terms
{{gene.symbol}}: {{ gene.description }}
Save List to My RGD
| Create Name: | |
| Description: |
|
| Save what matters to you |
| {{ loginError }} |
| Sign in with your RGD account |
| Create New Account | Recover Password |
{{ watchLinkText }}
Select categories you would like to watch. Updates to this gene will be send to {{ username }}
Analyze GeneStrainQTL List |
 Gene Annotator (Functional Annotation) unavailable |
 Gene Annotator (Annotation Distribution) unavailable |
 Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable |
Gene Annotator (Functional Annotation) |
Gene Annotator (Annotation Distribution) |
Variant Visualizer (Genomic Variants) |
 InterViewer (Protein-Protein Interactions) unavailable |
 Gviewer (Genome Viewer) unavailable |
 Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable |
InterViewer (Protein-Protein Interactions) |
GViewer (Genome Viewer) |
Variant Visualizer (Damaging Variants) |
 Gene Annotator (Annotation Comparison) unavailable |
 OLGA (Gene List Generator) unavailable |
 |
Gene Annotator (Annotation Comparison) |
OLGA (Gene List Generator) |
Excel (Download) |
 MOET (Multi-Ontology Enrichement) unavailable |
 GOLF (Gene-Ortholog Location Finder) unavailable |
|
MOET (Multi-Ontology Enrichement) |
GOLF (Gene-Ortholog Location Finder) |
Gene Ontology AnnotationsDisease Annotations
|
|
Gene-Chemical Interaction Annotations
|
|
|
Gene Ontology AnnotationsBiological Process
|
Cellular Component
|
|
Molecular Function
|
|
|
References - curated| 1. | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 2. | RGD automated import pipeline for gene-chemical interactions |
References - uncurated| PubMed | 24220035 |
Genomics
Comparative Map Data| Adamts15 (Rattus norvegicus - Norway rat) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ADAMTS15 (Homo sapiens - human) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Adamts15 (Mus musculus - house mouse) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Adamts15 (Chinchilla lanigera - long-tailed chinchilla) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ADAMTS15 (Pan paniscus - bonobo/pygmy chimpanzee) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ADAMTS15 (Canis lupus familiaris - dog) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Adamts15 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ADAMTS15 (Sus scrofa - pig) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ADAMTS15 (Chlorocebus sabaeus - African green monkey) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Adamts15 (Heterocephalus glaber - naked mole-rat) |
No map positions available. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Position Markers| RH135150 |
|
QTLs in Region (Rnor_6.0)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
miRNA Target Status
Predicted Target Of
| The detailed report is available here: | | Full Report | | CSV | | TAB | | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
||||||||
Expression
RNA-SEQ ExpressionHigh: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM
| alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
| High | |||||||||||||
| Medium | 4 | 2 | 2 | 2 | 6 | 22 | 22 | 11 | |||||
| Low | 3 | 39 | 43 | 27 | 19 | 27 | 8 | 11 | 68 | 13 | 17 | 8 | |
| Below cutoff | 12 | 12 | 12 | 2 |
View RNA-SEQ Expression Data
Sequence
Nucleotide Sequences| RefSeq Transcripts | NM_001106810 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR07069574 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| AAHX01053902 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01053903 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| CH474007 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
Reference Sequences
| RefSeq Acc Id: | ENSRNOT00000013341 ⟹ ENSRNOP00000013341 | ||||||||
| RefSeq Status: | |||||||||
| Type: | CODING | ||||||||
| Position: |
|
| RefSeq Acc Id: | NM_001106810 ⟹ NP_001100280 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Position: |
|
||||||||||||||||||||
| Sequence: |
TGCACCGCGAACGGCTACGGTTCGCAGAGCAGCCCGCCACCTCGCGTCACTTCTCCACCGCAAAhide sequence |
Protein Sequences| Protein RefSeqs | NP_001100280 | (Get FASTA) | NCBI Sequence Viewer |
| GenBank Protein | EDL83322 | (Get FASTA) | NCBI Sequence Viewer |
Reference Sequences
| RefSeq Acc Id: | NP_001100280 ⟸ NM_001106810 |
| - Peptide Label: | precursor |
| - UniProtKB: | D3ZXM1 (UniProtKB/TrEMBL) |
| - Sequence: |
MLLLGISILALAWRPASSSEPEWEVVVPIRRDPDINGRHYYRRGTEDSGDQGLIFQITAFQQDFhide sequence |
| RefSeq Acc Id: | ENSRNOP00000013341 ⟸ ENSRNOT00000013341 |
Protein Domains
Peptidase M12B
TranscriptomePromoters| RGD ID: | 13695822 | ||||||||
| Promoter ID: | EPDNEW_R6347 | ||||||||
| Type: | single initiation site | ||||||||
| Name: | Adamts15_1 | ||||||||
| Description: | ADAM metallopeptidase with thrombospondin type 1 motif, 15 | ||||||||
| SO ACC ID: | SO:0000170 | ||||||||
| Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
| Experiment Methods: | Single-end sequencing. | ||||||||
| Position: |
|
Strain Variation
Strain Sequence Variants (Rnor 6.0)
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
Damaging VariantsAssembly: Rnor_5.0
| Chromosome | Start Pos | End Pos | Reference Nucleotide | Variant Nucleotide | Variant Type | Strain |
| 8 | 32010642 | 32010643 | A | G | snv | LE/Stm (SOLiD) (KNAW), LE/Stm (KyushuU), LE/Stm (Illumina) (KNAW) |
Assembly: Rnor_6.0
| Chromosome | Start Pos | End Pos | Reference Nucleotide | Variant Nucleotide | Variant Type | Strain |
| 8 | 31984079 | 31984080 | A | G | snv | LE/Stm (RGD) |
Assembly: RGSC_v3.4
| Chromosome | Start Pos | End Pos | Reference Nucleotide | Variant Nucleotide | Variant Type | Strain |
| 8 | 30690360 | 30690361 | A | G | snv | LE/Stm (ICL), LE/Stm (KNAW) |
Additional Information
External Database Links| Database | Acc Id | Source(s) |
| AGR Gene | RGD:1309770 | AgrOrtholog |
| Ensembl Genes | ENSRNOG00000009892 | Ensembl, ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000013341 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000013341 | ENTREZGENE, UniProtKB/TrEMBL |
| Gene3D-CATH | 2.20.100.10 | UniProtKB/TrEMBL |
| 3.40.390.10 | UniProtKB/TrEMBL | |
| InterPro | ADAM_CR_2 | UniProtKB/TrEMBL |
| ADAM_Cys-rich | UniProtKB/TrEMBL | |
| ADAM_spacer1 | UniProtKB/TrEMBL | |
| ADAMTS/ADAMTS-like | UniProtKB/TrEMBL | |
| MetalloPept_cat_dom | UniProtKB/TrEMBL | |
| Pept_M12B_ADAM-TS8 | UniProtKB/TrEMBL | |
| Peptidase_M12B | UniProtKB/TrEMBL | |
| Peptidase_M12B_N | UniProtKB/TrEMBL | |
| Thrombospondin_1_rpt | UniProtKB/TrEMBL | |
| TSP1_rpt_sf | UniProtKB/TrEMBL | |
| KEGG Report | rno:300474 | UniProtKB/TrEMBL |
| NCBI Gene | 300474 | ENTREZGENE |
| Pfam | ADAM_CR_2 | UniProtKB/TrEMBL |
| ADAM_spacer1 | UniProtKB/TrEMBL | |
| Pep_M12B_propep | UniProtKB/TrEMBL | |
| Reprolysin | UniProtKB/TrEMBL | |
| TSP_1 | UniProtKB/TrEMBL | |
| PhenoGen | Adamts15 | PhenoGen |
| PRINTS | ADAMTS8 | UniProtKB/TrEMBL |
| ADAMTSFAMILY | UniProtKB/TrEMBL | |
| PROSITE | ADAM_MEPRO | UniProtKB/TrEMBL |
| TSP1 | UniProtKB/TrEMBL | |
| SMART | ACR | UniProtKB/TrEMBL |
| TSP1 | UniProtKB/TrEMBL | |
| Superfamily-SCOP | TSP1 | UniProtKB/TrEMBL |
| UniGene | Rn.41227 | ENTREZGENE |
| UniProt | D3ZXM1 | ENTREZGENE, UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2008-09-18 | Adamts15 | ADAM metallopeptidase with thrombospondin type 1 motif, 15 | Adamts15 | a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 15 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
| 2008-04-30 | Adamts15 | a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 15 | Adamts15_predicted | a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 15 (predicted) | 'predicted' is removed | 2292626 | APPROVED |
| 2006-03-30 | Adamts15_predicted | a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 15 (predicted) | a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 15 (predicted) | Name updated | 1299863 | APPROVED | |
| 2005-01-12 | Adamts15_predicted | a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 15 (predicted) | Symbol and Name status set to approved | 70820 | APPROVED |
 |
| More on Adamts15 | |
|
Alliance Gene |
|
NCBI Gene |
|
Ensembl Gene |
|
|
JBrowse: rn5 rn6 |
|
NCBI Genome Data Viewer |
| RGD Object Information | |
| RGD ID: | 1309770 |
| Created: | 2005-01-12 |
| Species: | Rattus norvegicus |
| Last Modified: | 2020-03-04 |
| Status: | ACTIVE |
