Gdf7 (growth differentiation factor 7)

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Gene: Gdf7 (growth differentiation factor 7) Rattus norvegicus

Analyze

Symbol:

Gdf7

Name:

growth differentiation factor 7

RGD ID:

620105

Description:

Predicted to have cytokine activity and identical protein binding activity. Predicted to be involved in several processes, including morphogenesis of an epithelium; nervous system development; and transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to localize to extracellular space. Orthologous to human GDF7 (growth differentiation factor 7); PARTICIPATES IN transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH ammonium chloride; bisphenol A; C60 fullerene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

growth/differentiation factor 7; LOC366572

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	6	33,496,596 - 33,507,626 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	33,503,217 - 33,507,542 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	43,281,722 - 43,292,667 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	31,857,104 - 31,861,428 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	6	31,860,390 - 31,860,592 (-)	NCBI
Celera	6	30,628,297 - 30,632,622 (-)	NCBI		Celera
Cytogenetic Map	6	q14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

4,4'-sulfonyldiphenol (ISO)

5-aza-2'-deoxycytidine (ISO)

ammonium chloride (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

bisphenol F (ISO)

C60 fullerene (EXP)

decabromodiphenyl ether (ISO)

dioxygen (ISO)

fonofos (ISO)

parathion (ISO)

terbufos (ISO)

testosterone (ISO)

Tetrachlorobisphenol A (ISO)

triclosan (ISO)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

activin receptor signaling pathway (ISO)

axon guidance (ISO)

BMP signaling pathway (IBA,ISO)

branching morphogenesis of an epithelial tube (ISO)

cell fate commitment (ISO)

epithelial cell differentiation (ISO)

forebrain morphogenesis (ISO)

gland morphogenesis (ISO)

midbrain development (ISO)

morphogenesis of an epithelial fold (ISO)

neural tube development (ISO)

pathway-restricted SMAD protein phosphorylation (ISO)

positive regulation of gene expression (ISO)

positive regulation of neuron differentiation (ISO)

positive regulation of pathway-restricted SMAD protein phosphorylation (IBA,ISO)

positive regulation of tendon cell differentiation (ISO)

positive regulation of transcription, DNA-templated (ISO)

reproductive structure development (ISO)

roof plate formation (ISO)

SMAD protein signal transduction (IBA)

spinal cord association neuron differentiation (ISO)

Cellular Component

extracellular region (ISO)

extracellular space (IBA,NAS)

Molecular Function

cytokine activity (IBA)

growth factor activity (IEA)

identical protein binding (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

transforming growth factor-beta superfamily mediated signaling pathway (IEA)

References

References - curated


1.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	NCBI rat LocusLink and RefSeq merged data July 26, 2002
3.	Pipeline to import KEGG annotations from KEGG into RGD
4.	RGD automated data pipeline
5.	RGD automated import pipeline for gene-chemical interactions
6.	Sena K, etal., J Dent Res 2003 Mar;82(3):166-71.

Additional References at PubMed

PMID:9786991	PMID:10693795	PMID:11356021	PMID:11356025	PMID:12639970	PMID:12741987	PMID:15883363	PMID:16049014	PMID:21412429	PMID:21469182

Genomics

Comparative Map Data

Gdf7
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	6	33,496,596 - 33,507,626 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	33,503,217 - 33,507,542 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	43,281,722 - 43,292,667 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	31,857,104 - 31,861,428 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	6	31,860,390 - 31,860,592 (-)	NCBI
Celera	6	30,628,297 - 30,632,622 (-)	NCBI		Celera
Cytogenetic Map	6	q14	NCBI

GDF7
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	2	20,667,144 - 20,679,243 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	2	20,667,144 - 20,679,243 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	2	20,866,424 - 20,871,250 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	20,729,905 - 20,734,731 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	2	20,788,051 - 20,792,878	NCBI
Celera	2	20,728,800 - 20,733,639 (+)	NCBI
Cytogenetic Map	2	p24.1	NCBI
HuRef	2	20,623,337 - 20,628,206 (+)	NCBI		HuRef
CHM1_1	2	20,795,793 - 20,800,641 (+)	NCBI		CHM1_1

Gdf7
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	8,347,918 - 8,351,954 (-)	NCBI	GRCm39		mm39
GRCm38	12	8,297,918 - 8,301,954 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	8,297,918 - 8,301,954 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	8,304,724 - 8,308,760 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	12	8,323,926 - 8,327,962 (-)	NCBI			mm8
Celera	12	8,691,764 - 8,695,838 (-)	NCBI		Celera
Cytogenetic Map	12	A1.1	NCBI

Gdf7
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955469	3,134,355 - 3,149,177 (+)	NCBI	ChiLan1.0	ChiLan1.0

GDF7
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	2A	20,766,776 - 20,773,082 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
Mhudiblu_PPA_v0	2A	20,651,617 - 20,664,586 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

GDF7
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	15,627,739 - 15,636,513 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Gdf7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936493	10,808,714 - 10,812,761 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GDF7
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	117,588,431 - 117,592,466 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	117,586,188 - 117,592,541 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	125,548,358 - 125,553,115 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GDF7
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1 Ensembl	14	87,023,028 - 87,027,194 (-)	Ensembl
ChlSab1.1	14	87,013,821 - 87,027,977 (-)	NCBI

Gdf7
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624738	3,281,828 - 3,286,627 (+)	NCBI

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
738023	Alc17	Alcohol consumption QTL 17	3.1	0.003	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	6	1	35623029	Rat
1354616	Despr12	Despair related QTL 12		0.0012	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	6	1	35623029	Rat
1549905	Stresp10	Stress response QTL 10	6.83	0.0066	stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	6	1	35623029	Rat
2300176	Bmd51	Bone mineral density QTL 51	11.7	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	6	1	35623029	Rat
2300190	Bmd52	Bone mineral density QTL 52	11.2	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	6	1	35623029	Rat
1331743	Uae28	Urinary albumin excretion QTL 28	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	6	1	41917988	Rat
9589048	Scfw3	Subcutaneous fat weight QTL 3	4.57	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	6	1	42388212	Rat
9589129	Insul24	Insulin level QTL 24	19.06	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	6	1	42388212	Rat
7411603	Foco13	Food consumption QTL 13	5.5	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	6	1	42388212	Rat
7411542	Bw127	Body weight QTL 127	5.5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	1	42388212	Rat
8552962	Pigfal16	Plasma insulin-like growth factor 1 level QTL 16	9.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	6	1	42388212	Rat
2293709	Bss23	Bone structure and strength QTL 23	5.18	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	6	1	43665660	Rat
2293650	Bss31	Bone structure and strength QTL 31	5.05	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	6	1	43665660	Rat
2293656	Bss28	Bone structure and strength QTL 28	6.79	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	6	1	43665660	Rat
7411584	Foco4	Food consumption QTL 4	4.3	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	6	1	44015370	Rat
738024	Sach5	Saccharine consumption QTL 5	3.9	0.00039	consumption behavior trait (VT:0002069)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	6	1	44570292	Rat
2301972	Bp325	Blood pressure QTL 325	4.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	1	75623393	Rat
2292589	Emca10	Estrogen-induced mammary cancer QTL 10		0.048	mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	6	1120393	46120393	Rat
1354664	Slep2	Serum leptin concentration QTL 2	4.49		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	6	1120393	75023446	Rat
1576309	Emca7	Estrogen-induced mammary cancer QTL 7	4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	2537030	111715717	Rat
1578665	Bss16	Bone structure and strength QTL 16	4.4		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	6	6161722	76002731	Rat
1578668	Bmd14	Bone mineral density QTL 14	3.8		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	6	6161722	76002731	Rat
4145119	Mcs25	Mammary carcinoma susceptibility QTL 25		0.0001	mammary gland integrity trait (VT:0010552)	ratio of deaths to total study population during a period of time (CMO:0001023)	6	7009971	115379601	Rat
634322	Bw12	Body weight QTL 12	0		body mass (VT:0001259)	body weight (CMO:0000012)	7	10173862	55173862	Rat
1300128	Rf16	Renal function QTL 16	3.89		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	13122958	34367603	Rat
1300164	Rf15	Renal function QTL 15	3.12		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	13122958	57516539	Rat
10401812	Kidm54	Kidney mass QTL 54			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	16810107	61810107	Rat
10401800	Kidm49	Kidney mass QTL 49			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	16810107	61810107	Rat
8552910	Pigfal5	Plasma insulin-like growth factor 1 level QTL 5	4.3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	6	19417887	64417887	Rat
1641898	Colcr4	Colorectal carcinoma resistance QTL4	3.71	0.0007	intestine integrity trait (VT:0010554)	well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)	6	21515302	65784818	Rat
2293839	Kiddil2	Kidney dilation QTL 2	4.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	22042854	84763421	Rat
2293841	Kiddil4	Kidney dilation QTL 4	4.4		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	22042854	84763421	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	216
Count of miRNA genes:	157
Interacting mature miRNAs:	174
Transcripts:	ENSRNOT00000007928
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	hemolymphoid system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium									4
Low			2				17	15	7	2
Below cutoff	2	23	10	4	5	6	44	14	18	7	5

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001170350	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006239878	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAHX01042566	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB087406	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC142360	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000007928 ⟹ ENSRNOP00000007928

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	6	33,503,217 - 33,507,542 (-)	Ensembl

RefSeq Acc Id:

NM_001170350 ⟹ NP_001163821

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	6	33,503,217 - 33,507,542 (-)	NCBI
Rnor_5.0	6	43,281,722 - 43,292,667 (-)	NCBI
RGSC_v3.4	6	31,857,104 - 31,861,428 (-)	RGD
Celera	6	30,628,297 - 30,632,622 (-)	RGD

Sequence:

show sequence

GCCGGCCGGCCCACGGAGCCCATGGACCTGAGCGCTGCCGCCGCGCTGTGTCTCTGGCTGCTGA
GCGCTTGCCGTCCCCGCGACGGGCTGGAAGCTGCCGCGGTGCTCCGAGCGGCGGGAGCAGGACC
AGCCTGGAGCCCGGGGGGCGGCGGCGGCGGGCGGACCCTCGCCCCAGCTCCAGGCCCTTCAGCT
CTCCAGGCCGCTGCGGTTCCCGGTCCCCGCGCTGTGCGCCGCGCCGCGGGCTCCGGCTTCAGGA
ACGGCTCGGTGGTGCCACACCACTTCATGATGTCGCTTTACCGGAGCCTGGCGGGGAGGGCTCC
TGCCGCGGCAACTTCAGGGCACGGGCGCGTGGACACGATCACCGGCTTCACAGACCAAGCAACT
CAAGGCCAGAGCTTCTTATTCGACGTATCCAGCCTCTCGGACTCCGACGAGGTGGTGAATGCCG
AGCTGCGCGTGCTGCGCCGGAGGTCTCCGGAGCCAGACAGGGACAGTGCGACCCTCCCTCCGCT
GCTGCTGCTGTCCACGTGCCCGGACGAGGCCGGCACAGCTCACTTGCTGCACTCGCGGGCCGCC
GAGCCCCTAGACAGCGCGCGCTGGGAAGCGTTCGACGTGACGGACGCGGTGCAGAGTCACCGCC
GCTGGCCGCGCACCTCCCGCAAGTTCTGCCTGGTGCTGCGCGCGGTGACGGGCGCCGAGAGCAG
CCCGCTGGCCCTGAGAAGACTGGGCTTCGGCTGGCCTGGCGGTGGCGACGGCGGCGGCACGGCA
GCCGAGGAGCGCGCGCTGTTGGTGATCTCCTCCCGCACGCACAGGAAAGAGAGTCTGTTCCGGG
AGATACGCGCCCAGGCCCGCGCTCTCCGGGCCGCCGCAGAGCTGCCACCAGATCCAGGACTAGG
CGCTGGATCTCGGAAAGCCACCCCGGGCGGTCGCAGGCGGCGACGGACCGCGCTGGCTGGGACT
CGGGGAGCGCAGGGAAGCGGTGGCGGCGGTGGGGGCGGTGGCGGCGGCGGCGGCGGCGGCGGTG
GCGCAGGCAGGGGCCACGGGCGCAGAGGCAGGAGCCGCTGCAGTCGCAAGCCACTGCATGTGGA
CTTTAAGGAGCTGGGCTGGGACGACTGGATCATCGCGCCATTAGACTACGAGGCATACCACTGC
GAGGGCGTTTGCGACTTTCCTCTGCGCTCGCACCTGGAGCCTACCAACCACGCCATCATCCAGA
CGCTGCTCAACTCCATGGCGCCGGATGCGGCGCCAGCCTCCTGCTGCGTGCCCGCACGTCTCAG
CCCCATCAGCATCCTCTACATCGACGCCGCCAACAACGTGGTCTACAAGCAGTACGAGGACATG
GTGGTAGAGGCCTGCGGCTGCAGGTAGCATGAGGTCTGGGGAGGGTTTTGCTGCCCAGGACCCT
AGCCGAAGAGCGTGAGTCACCAGGCCCGAGGGAAGGCGGACAATGTTCTCTGCCAGCAGAGGAG
AGCACACAGTTAACACTCACATTTACACACTCCTTCACTCGCGCACATGTTTACTGTGGATGCC
AGGCGCTGAAAGCCTTGGACAGAGATAGTATGCAGCGACTTGATGTCATAGCCGTGTTCGTTTG
CTGACGTTGATACAAACCTCTGTCCCTTTGGGGAGAGGGAAGGGTGTCTGTGTTTATGTT

hide sequence

RefSeq Acc Id:

XM_006239878 ⟹ XP_006239940

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	6	33,496,596 - 33,507,626 (-)	NCBI
Rnor_5.0	6	43,281,722 - 43,292,667 (-)	NCBI

Sequence:

show sequence

GCTGCGCACACTTCCCCCATTATTAAACACTATGTTCAAAAGGCGTCGGGGGACTTCCCGGAGC
CACGGAGCCCGTGTCGCGCGGCCGGCCGGCCCACGGAGCCCATGGACCTGAGCGCTGCCGCCGC
GCTGTGTCTCTGGCTGCTGAGCGCTTGCCGTCCCCGCGACGGGCTGGAAGCTGCCGCGGTGCTC
CGAGCGGCGGGAGCAGGACCAGCCTGGAGCCCGGGGGGCGGCGGCGGCGGGCGGACCCTCGCCC
CAGCTCCAGGCCCTTCAGCTCTCCAGGCCGCTGCGGTTCCCGGTCCCCGCGCTGTGCGCCGCGC
CGCGGGCTCCGGCTTCAGGAACGGCTCGGTGGTGCCACACCACTTCATGATGTCGCTTTACCGG
AGCCTGGCGGGGAGGGCTCCTGCCGCGGCAACTTCAGGGCACGGGCGCGTGGACACGATCACCG
GCTTCACAGACCAAGCAACTCAAGAGGAATCGGCGGCCGAGCCAGGCCAGAGCTTCTTATTCGA
CGTATCCAGCCTCTCGGACTCCGACGAGGTGGTGAATGCCGAGCTGCGCGTGCTGCGCCGGAGG
TCTCCGGAGCCAGACAGGGACAGTGCGACCCTCCCTCCGCTGCTGCTGCTGTCCACGTGCCCGG
ACGAGGCCGGCACAGCTCACTTGCTGCACTCGCGGGCCGCCGAGCCCCTAGACAGCGCGCGCTG
GGAAGCGTTCGACGTGACGGACGCGGTGCAGAGTCACCGCCGCTGGCCGCGCACCTCCCGCAAG
TTCTGCCTGGTGCTGCGCGCGGTGACGGGCGCCGAGAGCAGCCCGCTGGCCCTGAGAAGACTGG
GCTTCGGCTGGCCTGGCGGTGGCGACGGCGGCGGCACGGCAGCCGAGGAGCGCGCGCTGTTGGT
GATCTCCTCCCGCACGCACAGGAAAGAGAGTCTGTTCCGGGAGATACGCGCCCAGGCCCGCGCT
CTCCGGGCCGCCGCAGAGCTGCCACCAGATCCAGGACTAGGCGCTGGATCTCGGAAAGCCACCC
CGGGCGGTCGCAGGCGGCGACGGACCGCGCTGGCTGGGACTCGGGGAGCGCAGGGAAGCGGTGG
CGGCGGTGGGGGCGGTGGCGGCGGCGGCGGCGGCGGCGGTGGCGCAGGCAGGGGCCACGGGCGC
AGAGGCAGGAGCCGCTGCAGTCGCAAGCCACTGCATGTGGACTTTAAGGAGCTGGGCTGGGACG
ACTGGATCATCGCGCCATTAGACTACGAGGCATACCACTGCGAGGGCGTTTGCGACTTTCCTCT
GCGCTCGCACCTGGAGCCTACCAACCACGCCATCATCCAGACGCTGCTCAACTCCATGGCGCCG
GATGCGGCGCCAGCCTCCTGCTGCGTGCCCGCACGTCTCAGCCCCATCAGCATCCTCTACATCG
ACGCCGCCAACAACGTGGTCTACAAGCAGTACGAGGACATGGTGGTAGAGGCCTGCGGCTGCAG
GTAGCATGAGGTCTGGGGAGGGTTTTGCTGCCCAGGACCCTAGCCGAAGAGCGTGAGTCACCAG
GCCCGAGGGAAGGCGGACAATGTTCTCTGCCAGCAGAGGAGAGCACACAGTTAACACTCACATT
TACACACTCCTTCACTCGCGCACATGTTTACTGTGGATGCCAGGCGCTGAAAGCCTTGGACAGA
GATAGTATGCAGCGACTTGATGTCATAGCCGTGTTCGTTTGCTGACGTTGATACAAACCTCTGT
CCCTTTGGGGAGAGGGAAGGGTGTCTGTGTTTATGTTGCGGTAATTGGCACTAAATCCAAGTAG
AAACGGGTTAGCATTGGATTCTCCTTTTATTTGGAGGCCGTGTGGCTCTGCTAGGTGGCTGGAT
TCCTGACACTGGACGTGGAGTTCCACTGTAGGGCTGTAATACCCAGATTCTCTTGGGGGGTGGG
CATTGGGAATCTTCAAAAAGGACCCGCTGGGGGTCGCAAGGAGGCGCACATCTCCTAGACACGT
CTCACGTGGTACTGTCTCAGTTTTGAAAAGGAAGCTTTATGCAAACGAATGGGTTGTGCTGCAA
AAGCCAAGACCGACTTAAAAACATCAATTCCAATTAGGAATGATCGGGAAAGTAGGAAGAACAG
CTTTCTCCTGAGGATGTGTGTGAAATGGAGGAGACAGGTGAGGAATAGGATAGGATCTGCCAGG
TTTAGAAGCGTCTAGAAGGCAGTAGCAGGAGGAAGATAGAGCAATGGCTGTATACGGGGTAGTG
GAGGATTGTGCCAAGAGGATTTCCTAAGAGGCTGGAAACGGCTGTCTGTCAGGGAGTCAGTGTC
CCAGGGCCACCAGCTTCAGCTTCTCACCTTCAGAAGTCAAGCGCATTTGTCAGGTAGGCACAGT
CCCTTCCAAAAGACAATGAGTGCTTGTGCTTAGCTTCCCTTTGTTAGCACATCTGTGGTGGCCT
GTGTGTGCCTTGTGCCTTTGACTGTGTTCCTTGCTTTTTTTTTTTTTTTTTTTTTTTTTTTTTG
GCAGTGTGACAATGATGAGGGGGAGTGAAGCCACACAAATGCCTTTGTCAGACCTAAACACACA
GTCTGGGAGGAGTCGGGTCCTTGCTCCTAGATGGTGGAATGAGTGGGTTGCAGGCCTGTCTCCC
AGCTCCAGAATTTTTTGTTCTGCAGAGGCATTTGATTTCTTGGTACCGGTTCATCCTCTGGGGC
CTCCTGTCAATGGCTGGGGAAACAGAAACAAGCTGGGCTGCACCTGTCAGAGGGCTCAGAGGAC
CTCTTTAACATTACTCTAGGTTTTCTAATTTAGGCTTTGGGAGAGGAGTTAATTCTGTCTTGAA
TGCCAAGGCCCAGGGCAGTTTACAGGTATTTTATTTTAGTTCTTAGTGGATACTCCTGAGAGAC
AGGAAGGATGAAAATTTAGATTCAGTGAATTTTATATTTAAGAGTCACATCTGAGTCCTTTTCA
TCCCCTCCCCCCATGTATAATTTATCCTTTTAGAATGTGAACTTATTGACTGGGGATCTCTGTA
ATCGGAAAACACAACACTTTCATCATTTTTTTTCTTTTTCACAAAGTGGCTACTCTTGATACAA
TTTCTTTCTTTCTTTTTTTCTTTCTTTCTTTCTTTCTTTTTCTTTTCTTTTTTCTTTTTTTGGC
GCCTGGGCAGAGATGTACATCCAGATTTCTGGATTCTGCCAGGAAACTTCCCTCTTCTGTTTAA
GATGATTTAATAGTGGCTGTTCTCGTGTCACAATGGAGAATAAAATGCTTGAAAAGCTAAAAGC
TGTATTAGAAAGTTTAGAAAAAAAATGAAAATTTACAGTTGACTATTATTTTTTGAGAAAAACT
TAGAGTGTTTACTACTTTTGTATAGAAGCAAACATTTTAATACTTTTTTTGTGACTAGGCCAAA
CAACTTTTGGGGGAAAATAACTTGATTTAGCTTGGTTGTTATACAGTAGGGAAATATCCATTAG
CCCTGCCCCTTTTAACTTGATGACTTCTTTCTAACAAGACATATTGCATGTGACGTTTTGAGAG
TGGGTTTTCCCCTGTGTTGAGGTTGTACCCACAAGAGGGTACTGTCCTTAGAATGGTCACCATT
GTCTTCTGTCTCTGAGACCTCCGGTGCTCTTTGTTTACTGAATGATCGGAACTTCTCCCAGGTT
TCCCTTGAACCTTTGTAGAACTATCCCTAGCAACAGTGCCCCTCTTCTGGTTCTATTTCCTATG
GCCATCTTCTAGAGGATGTATTTTGTGACCACAAAAGGGCTAACCGCATGTGGGGCAGATGGGA
TGTGGTTAAACTAGCTTGCCAAGAGGCGGAGAAAGACTGCTGCCTGCACAGTTGGGAACACTCT
TCATCATCTGCCTGTCACCTAGGGTTTAGTGGGGCTGGGTGACCAGGACAAACTCAGCTGAAAT
CCTTGGTTGGATGCTGTGGTCAGCACAGACTATGTCTGTTAGGGTGTTCCCTCATCCCCAGCCT
GAGATCACCAAAATCTTCCTGCTGAAGTAAACAGAATTCTCCATGTTGCTGGGGAACAGTGCAC
AGCTACTTGAGATAACCTGAACCACTACTTCAAGTGAGTGGAGACTGACAGTCCCAGCTCAGGA
AGCAGGGGCAGGCCAGCTGGGCCTACAGGCTTGCCAGACACTAAGCTGGTCTGGTTTGCTGCTT
GAAGCCATAATTTATGGATTAAAGTAACTCCTCCATTGGCAGGAAAGCATTTTCAGGATTCCTA
GACTCTGGCCTTGTGGGATTTGGGGTTACCAAGCAGCTGGGCTGGACCTTTGCAGAGAGGGTGG
TCGGTTACTTAATCTTATTGTGAGGAAAAATGGCTGGATCTGTGCTGGGCTGTGTAGTGTTCAT
GCTCGGCCTTTGCCCACTTTCCTGGCATTTCCATGCTCAAGCGGCATGGGGTAATAAGCTTGTG
CATTGTGGGTGGTAGCGCTGCCGAAGGTCAGCGGATCTGTCTGTCCCATGCTGATCTTCCCTGA
CAATCATCATGGTGTCAGCAGGGACAGAAGCTGGATGTGAGTCTTGAAGAGAGCTTGGGCATGC
TCTGGATGCCAATCCTACAGGTCCCCACCTCCCCAGCTACTCCCACTCAAGGCCAACACAAGTG
CGACTGTAGATTGCATTTCTTCTTAAATTAGGGTATCCAGGCACATTCTTTCCAAGAGCATCTT
GTGCCCCAAGAGGCTCGCTCCTCCTTTGAGTCTACCTTGAAAAGGCAATAGAAAGTAGAGGACA
CACTGCCTTGATGGTTCCCCAGAGAGTGTCCTCTTGGGGGCCACATATAGGGAGGCAGGGCCCT
TGCCAATGGACTCAGCACAGGGGCCTCAGCAAGTGGGTTGAGAAGGTAGAGGTCTGGAGGATGG
AGGTCTGAAAGCAGCTTTCTGTCAGGGAGCAGTGGGTCTCCATTTCCCTTTTGTAAGTGTCAGG
GGTGGGAAGGGAAGAAAGAATGTGGATAAGATGTCAAAGTTGTTACCCAATTTGAGGAGTGGGT
GAGACATTACTAGATCTCCATAGGGTGGTCAGCTGATGTCTCTGGTTAGCCTTAGAATGAAGGC
TTCTCTATACCCAGGAGTTAGTTCTCTTCATAGTGTAGCCTGGACTCACCTTGTAGGAGACCAT
GCAGGCATCAGGTCTCTACAGGTGCCTCTCTTGAGAGACATCTGAGACACTCAGTCATGGGCAG
TCATCTCCCTGCCTAGATCTTCAGCATCTGTCCCTTACATGACAACTGCTCCAGTCCCAAGGTT
CCAAGATTCTTCTTAGAAAGTTGTCCAGACACTCCAAGACAAATAATCCTAGCCACAGCCGCAT
CACCAGAGTTCTGAGAGTGTGGGCTTGTGCACTTATCTGAATGCTGGAGCTTAGCAAACACTGC
TTCAGTTTTCTACCCAGGGTGGAGCAGGTGCAGGAGAGGCCAGGATCTGGGTCCTGGGCTTTGG
CTCCCCAACAGCCAGGAGCTGCTCTGTGCCCCCTGGTTGGAGAGTGTGCTTGTGTTCACATTGA
GTCACATCCAGGCTGAGCTTGCCAGGTGACTTTTTGAAAATGGTGGCAGAGTCAAGCATTAAAA
GAAACACTAAATGGGAAGAGTTCAGAAGAGGTTTATTTAGATCCTCCCTCCCCACCAGCTCTGC
TTTTTGTAGCAGATCCCTTTGCAGCTTTAGGCTGAAGCCAAGTTTTTTCTCCCCCCTCCTTTTT
TGGGCCAGAGCTAAGGACAGCACAAAGGGGTACCCCAATTGGGGCAGTGGTGAGGGAACTGTTC
TTAAGAGGACCAAATCCCAGGCTGCCATGAGCTCTCTTGAGTCAGCTGCTGTGAGCTCTGAGAT
CATCCAGGGACTGAGAGATGCTCTGCTTCTGACGTGCACACATCCTTCTTCAGGAGCCCTGCTG
CCCGTGCTGTGCTTGCAGACAGCTTACAACTTGGCTGTAGACCTCCAGCCAGGCAGAACTGGGG
ATGGTGCCTCCTGGCAGCAGTGGCAGTCATTACAACAAAGTGTAAGTCAGCATGGGCAGTGGAA
GGTGTGAGGTCACTGAAGACCAGTCTGCATTTCAAGGCTCTCTTGCTATTGTCAGTCAGTCGAT
GTACTCTCTTAGCAGCAAACCCGTTCACCTGGCAATGGTCCTGTTCAGTGCTGAGCTTACAGGC
CTCCTCCAGCATCTGTGAGGCAAACACAGGACTGGTTTCTTTCACATGCATCCCTTTCAATGGT
AAGAGGGCTGTGGCAACCATAGACACTTCCTGAGACTCGTTTCTGTGTTTGGTGTGAAGGTGTG
AGGAACACATTTTGCTCCAGCAGGTGAAGTCCCTTCCAGAGTGAAAACGCCGCTTTTAGAGGGA
GTGGCGAGAGAGAATCTGTAGCTCAGAATTTCTTATCCCTTTTGGTGGATACTGAAATAAGCTG
CCTAAAGAAATCAGAAAAGACTGAATGCCAAACCCAGGCACCGTGAGTGCTGTGCTACAAACGT
CCAGAACAAGGTCAGCTATTGTGTTTTCGCTAGCTGTTTTGCTATTATTTGAATGGTGGTGGCT
GGAGATGTGACCAGGCAGGAGGTGGGCATGGAGTTGTCTTCTTGTAGTTATGTAGTGCTCCATC
TGACCAACACTGGAATCCACCTCCCTAGTTCCAATGTCTAGCGATGGGATGAGATGCCATGTTT
TATATCTAGGGCCCTCAGACTCTCCTCTGTCAGTTTCCAGAACTATCTGGCCCGTCTAGCATGT
GTACATAGTGGACCAAAACAAGAGTTGTGGGAAAGGTGTTGCAGAAGTCCTGCTGAGTTAGAAG
CAAATGTGAATTGATCCCTCCAAAGCACACAATCTCAACTCCCTTGGTGTGCGTGTGTGTGTGT
GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTCCATGCCTGCAAGCTATTCA
TTCGAAGCGATTGCGTATAACCTGTCCCTACTTAGACAGTTAGTACTTCTAGACCCCTGTGACG
GCCTGGCTCCTTTAAGACAACTCATGTGGGCAATAGGAAACCCTTACAGGACTTCTCAGTGGAT
CAAGTCTGCAAGGCAGTGACAAGATGTTCTGGGGTTAGATGTGGGGGGCTTTCCCTGAGGCAGG
AGTGAGGTCCTAGATTCCTTCCGAGGTGCAGCAGCCTTTTGCTTTGAGGACTATGGGATGGCTT
GAGGAATGGGCCTTACTTTTGGAGTCAGCCTGTCAGAGTCATACAGAGTCAACCAATCTGCACT
GTGTATAACCGATGATCCAGTTTGGTGAGAAGGTTCAGCATGCAACATGCTTCCAGGCCGGGCA
ACAGGTTAGTGTTCCAAGCTGGGAACTGAGACTCTCTTGAGAGGAGTTTCTCTGGCATTCTCCA
CCTCTGATAAATCACAGACTAAACAGAGCACCCTTAGGGTCCTTTTATTTTTGCATTTCACATT
ATATGATAGGACAAACAGCTTTTATGTTTTTGGGTTCTTGGATAAAGTCATCATTAGGTCTTTT
AGTTGGGAATTTTTGTTTTTGTTTTTTTCTCACTCCAAATGAGCAGTTGATGCAATAAAAACAA
AAAATAGGGTATAACACAGTCTGTGACTTGCCCTTTTAGCGGATGAGGTAAGCAGTTCTGGGAA
GTTTGGGATATGTTTTCACCCTGCCTTATGTATAAATAAAGAAGTAGATCCTTCCAGTCCTCTC
ACTGGGGAGGTTGTTGCTGAATCCTGAACCTGCTCGTGGCATGATGCTGTGTAAGCAGGTCCTG
GGTGGGCGATGGAATGCGGCACACACGGTGAGTGGCCCGCAGCTTAAAAAGTAAATTTAATCTG
ATTCCTGATACTGTTATTTTAAGGAAATGGCAAAGCTGGAGCGATGTAATGCCACCAAAGCTCA
GTTCCACGCTGTTCCCTCAGCAGCTAAAGACAGAATTAATTAGTTTCAGGGGAAGTAGCTTTCA
TTTTGCAATGACACCTACTGTTCCTCAGGAGGTGGAGCAGGCGCTGGGAGGGAGAGGTTTTTAA
AACCCGAAATCTCCTTGTTGGCAATCTTCCAGCTCGGATTTGGCCAGAGCAGAGCTCCGTAGCT
TGCAGGCTACAGTTGAGCATCTGCCTGCTGCCCAGACTGGCCACTCAGGCGGTCCCCAATGACA
CTGTGCAATGCTGTTGTGACCAGACTAGCTAGCAGAGAACCAACCCTTGGAGGGCGGGCGTGAA
TCCATGTGTATATGTATTCTTGAATTTAAGTAGGTTGTACATATTGAAATGTAAATGACCTGTA
AAACAGCAAGCTATTTTTTCTTAACCATTACATAGCAGTATATATTTGCTAAACAGCTTGTACG
CCCATCATTCACCACTTTAATATTTTGTACAGACAGACAAAGTCGATTAAATATTTTATTCATA
AA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001163821	(Get FASTA)	NCBI Sequence Viewer
	XP_006239940	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAC02715	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_001163821 ⟸ NM_001170350
- Peptide Label:	precursor
- UniProtKB:	F1MAE8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MDLSAAAALCLWLLSACRPRDGLEAAAVLRAAGAGPAWSPGGGGGGRTLAPAPGPSALQAAAVP GPRAVRRAAGSGFRNGSVVPHHFMMSLYRSLAGRAPAAATSGHGRVDTITGFTDQATQGQSFLF DVSSLSDSDEVVNAELRVLRRRSPEPDRDSATLPPLLLLSTCPDEAGTAHLLHSRAAEPLDSAR WEAFDVTDAVQSHRRWPRTSRKFCLVLRAVTGAESSPLALRRLGFGWPGGGDGGGTAAEERALL VISSRTHRKESLFREIRAQARALRAAAELPPDPGLGAGSRKATPGGRRRRRTALAGTRGAQGSG GGGGGGGGGGGGGGGAGRGHGRRGRSRCSRKPLHVDFKELGWDDWIIAPLDYEAYHCEGVCDFP LRSHLEPTNHAIIQTLLNSMAPDAAPASCCVPARLSPISILYIDAANNVVYKQYEDMVVEACGC R hide sequence

RefSeq Acc Id:

XP_006239940 ⟸ XM_006239878

- Peptide Label:

isoform X1

- Sequence:

show sequence

MDLSAAAALCLWLLSACRPRDGLEAAAVLRAAGAGPAWSPGGGGGGRTLAPAPGPSALQAAAVP
GPRAVRRAAGSGFRNGSVVPHHFMMSLYRSLAGRAPAAATSGHGRVDTITGFTDQATQEESAAE
PGQSFLFDVSSLSDSDEVVNAELRVLRRRSPEPDRDSATLPPLLLLSTCPDEAGTAHLLHSRAA
EPLDSARWEAFDVTDAVQSHRRWPRTSRKFCLVLRAVTGAESSPLALRRLGFGWPGGGDGGGTA
AEERALLVISSRTHRKESLFREIRAQARALRAAAELPPDPGLGAGSRKATPGGRRRRRTALAGT
RGAQGSGGGGGGGGGGGGGGGGAGRGHGRRGRSRCSRKPLHVDFKELGWDDWIIAPLDYEAYHC
EGVCDFPLRSHLEPTNHAIIQTLLNSMAPDAAPASCCVPARLSPISILYIDAANNVVYKQYEDM
VVEACGCR

hide sequence

RefSeq Acc Id:

ENSRNOP00000007928 ⟸ ENSRNOT00000007928

Protein Domains

TGF_BETA_2

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Damaging Variants

Assembly: Rnor_5.0

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
6	43288760	43288761	C	G	snv	IS/Kyo (KyushuU)

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620105	AgrOrtholog
Ensembl Genes	ENSRNOG00000006046	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000007928	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000007928	ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH	2.10.90.10	UniProtKB/TrEMBL
InterPro	Cystine-knot_cytokine	UniProtKB/TrEMBL
	TGF-b_C	UniProtKB/TrEMBL
	TGF-b_N	UniProtKB/TrEMBL
	TGF-beta-rel	UniProtKB/TrEMBL
	TGFb_CS	UniProtKB/TrEMBL
KEGG Report	rno:252833	UniProtKB/TrEMBL
NCBI Gene	252833	ENTREZGENE
PANTHER	TGFbeta	UniProtKB/TrEMBL
Pfam	TGF_beta	UniProtKB/TrEMBL
	TGFb_propeptide	UniProtKB/TrEMBL
PhenoGen	Gdf7	PhenoGen
PROSITE	TGF_BETA_1	UniProtKB/TrEMBL
	TGF_BETA_2	UniProtKB/TrEMBL
SMART	TGFB	UniProtKB/TrEMBL
Superfamily-SCOP	SSF57501	UniProtKB/TrEMBL
UniGene	Rn.92437	ENTREZGENE
UniProt	F1MAE8	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-05-02	Gdf7	growth differentiation factor 7	Gdf7_predicted	growth differentiation factor 7 (predicted)	Data Merged	737654	APPROVED
2005-01-20	Gdf7	growth differentiation factor 7			Symbol and Name status set to approved	1299863	APPROVED
2005-01-12	Gdf7_predicted	growth differentiation factor 7 (predicted)			Symbol and Name status set to approved	70820	APPROVED
2002-08-07	Gdf7	growth differentiation factor 7			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Annotations - KEGG (archival)