Adamts13 (ADAM metallopeptidase with thrombospondin type 1 motif, 13) - Rat Genome Database

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Gene: Adamts13 (ADAM metallopeptidase with thrombospondin type 1 motif, 13) Rattus norvegicus
Analyze
Symbol: Adamts13
Name: ADAM metallopeptidase with thrombospondin type 1 motif, 13
RGD ID: 1311594
Description: Enables endopeptidase activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipopolysaccharide; and response to potassium ion. Located in extracellular space. Biomarker of cholestasis and non-alcoholic fatty liver disease. Human ortholog(s) of this gene implicated in thrombotic thrombocytopenic purpura. Orthologous to human ADAMTS13 (ADAM metallopeptidase with thrombospondin type 1 motif 13); INTERACTS WITH lidocaine; lipopolysaccharide; N-nitrosodimethylamine.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: A disintegrin and metalloproteinase with thrombospondin motifs 13; A disintegrin and metalloproteinase with thrombospondin motifs 13-like; a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 13; LOC102554283; LOC102554393; LOC362091
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2310,299,264 - 10,338,464 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl310,300,028 - 10,346,687 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.035,519,921 - 5,558,390 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl35,519,990 - 5,558,166 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0310,881,333 - 10,920,130 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.435,868,906 - 5,908,061 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera35,098,096 - 5,136,496 (+)NCBICelera
Cytogenetic Map3p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Regulation of the basolateral chloride/base exchangers AE1 and SLC26A7 in the kidney collecting duct in potassium depletion. Barone S, etal., Nephrol Dial Transplant. 2007 Dec;22(12):3462-70. Epub 2007 Sep 5.
2. Prevalence of the ADAMTS-13 missense mutation R1060W in late onset adult thrombotic thrombocytopenic purpura. Camilleri RS, etal., J Thromb Haemost. 2008 Feb;6(2):331-8. Epub 2007 Nov 20.
3. Inflammatory cytokines inhibit ADAMTS13 synthesis in hepatic stellate cells and endothelial cells. Cao WJ, etal., J Thromb Haemost. 2008 Jul;6(7):1233-5. Epub 2008 Jul 1.
4. Deficient activity of von Willebrand factor-cleaving protease in chronic relapsing thrombotic thrombocytopenic purpura. Furlan M, etal., Blood. 1997 May 1;89(9):3097-103.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Hepatic stellate cell damage may lead to decreased plasma ADAMTS13 activity in rats. Kume Y, etal., FEBS Lett. 2007 Apr 17;581(8):1631-4. Epub 2007 Mar 20.
8. Mild to moderate reduction of a von Willebrand factor cleaving protease (ADAMTS-13) in pregnant women with HELLP microangiopathic syndrome. Lattuada A, etal., Haematologica. 2003 Sep;88(9):1029-34.
9. Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura. Levy GG, etal., Nature. 2001 Oct 4;413(6855):488-94.
10. Severe malaria is associated with a deficiency of von Willebrand factor cleaving protease, ADAMTS13. Lowenberg EC, etal., Thromb Haemost. 2010 Jan;103(1):181-7. doi: 10.1160/TH09-04-0223. Epub 2009 Sep 15.
11. Von Willebrand factor cleaving protease (ADAMTS-13) in 123 patients with connective tissue diseases (systemic lupus erythematosus and systemic sclerosis). Mannucci PM, etal., Haematologica. 2003 Aug;88(8):914-8.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Shigatoxin triggers thrombotic thrombocytopenic purpura in genetically susceptible ADAMTS13-deficient mice. Motto DG, etal., J Clin Invest. 2005 Oct;115(10):2752-61.
14. Increased ADAMTS-13 proteolytic activity in rat hepatic stellate cells upon activation in vitro and in vivo. Niiya M, etal., J Thromb Haemost. 2006 May;4(5):1063-70.
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. Severe secondary deficiency of von Willebrand factor-cleaving protease (ADAMTS13) in patients with sepsis-induced disseminated intravascular coagulation: its correlation with development of renal failure. Ono T, etal., Blood. 2006 Jan 15;107(2):528-34. Epub 2005 Sep 27.
17. Impaired activity of plasma von Willebrand factor-cleaving protease may predict the occurrence of hepatic veno-occlusive disease after stem cell transplantation. Park YD, etal., Bone Marrow Transplant. 2002 May;29(9):789-94.
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Comprehensive gene review and curation RGD comprehensive gene curation
21. ADAMTS-13 is produced by glial cells and upregulated after spinal cord injury. Tauchi R, etal., Neurosci Lett. 2012 May 23;517(1):1-6. doi: 10.1016/j.neulet.2012.03.002. Epub 2012 Mar 7.
22. Potential for Recombinant ADAMTS13 as an Effective Therapy for Acquired Thrombotic Thrombocytopenic Purpura. Tersteeg C, etal., Arterioscler Thromb Vasc Biol. 2015 Nov;35(11):2336-42. doi: 10.1161/ATVBAHA.115.306014. Epub 2015 Sep 3.
23. Antibodies to von Willebrand factor-cleaving protease in acute thrombotic thrombocytopenic purpura. Tsai HM and Lian EC, N Engl J Med. 1998 Nov 26;339(22):1585-94.
24. Severe deficiency of the specific von Willebrand factor-cleaving protease (ADAMTS 13) activity in a subgroup of children with atypical hemolytic uremic syndrome. Veyradier A, etal., J Pediatr. 2003 Mar;142(3):310-7.
25. Increased production of ADAMTS13 in hepatic stellate cells contributes to enhanced plasma ADAMTS13 activity in rat models of cholestasis and steatohepatitis. Watanabe N, etal., Thromb Haemost. 2009 Aug;102(2):389-96.
26. Decreased levels of von Willebrand factor-cleaving protease in coronary heart disease and thrombotic thrombocytopenic purpura: study of a simplified method for assaying the enzyme activity based on ristocetin-induced platelet aggregation. Yoo G, etal., Br J Haematol. 2003 Apr;121(1):123-9.
27. Antithrombotic effect of grape seed proanthocyanidins extract in a rat model of deep vein thrombosis. Zhang Y, etal., J Vasc Surg. 2011 Mar;53(3):743-53. doi: 10.1016/j.jvs.2010.09.017. Epub 2010 Nov 20.
28. [The effects of activated protein C on the von Willebrand factor and von Willebrand factor cleaving protease of rat aortic endothelial cell induced by lipopolysaccharide]. Zheng GJ, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2012 Aug;24(8):487-9.
Additional References at PubMed
PMID:11535495   PMID:15136581   PMID:21878173  


Genomics

Comparative Map Data
Adamts13
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2310,299,264 - 10,338,464 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl310,300,028 - 10,346,687 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.035,519,921 - 5,558,390 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl35,519,990 - 5,558,166 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0310,881,333 - 10,920,130 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.435,868,906 - 5,908,061 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera35,098,096 - 5,136,496 (+)NCBICelera
Cytogenetic Map3p12NCBI
ADAMTS13
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389133,414,337 - 133,459,386 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl9133,414,358 - 133,459,402 (+)EnsemblGRCh38hg38GRCh38
GRCh379136,279,457 - 136,324,508 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369135,276,941 - 135,314,328 (+)NCBINCBI36Build 36hg18NCBI36
Build 349133,316,673 - 133,344,631NCBI
Celera9106,830,032 - 106,875,101 (+)NCBICelera
Cytogenetic Map9q34.2NCBI
HuRef9105,781,289 - 105,826,219 (+)NCBIHuRef
CHM1_19136,429,966 - 136,475,028 (+)NCBICHM1_1
T2T-CHM13v2.09145,628,765 - 145,673,828 (+)NCBIT2T-CHM13v2.0
Adamts13
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39226,863,363 - 26,899,638 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl226,863,428 - 26,899,640 (+)EnsemblGRCm39 Ensembl
GRCm38226,973,361 - 27,009,625 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl226,973,416 - 27,009,628 (+)EnsemblGRCm38mm10GRCm38
MGSCv37226,828,936 - 26,865,145 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36226,795,546 - 26,831,456 (+)NCBIMGSCv36mm8
Celera226,682,908 - 26,716,063 (+)NCBICelera
Cytogenetic Map2A3NCBI
Adamts13
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555132,764,186 - 2,786,187 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555132,761,386 - 2,786,447 (+)NCBIChiLan1.0ChiLan1.0
ADAMTS13
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19133,163,788 - 133,193,913 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9133,156,761 - 133,193,707 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v09104,541,051 - 104,582,574 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ADAMTS13
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1949,839,252 - 49,867,295 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl949,839,252 - 49,867,295 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha949,120,490 - 49,148,471 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0950,710,574 - 50,741,239 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl950,710,605 - 50,741,236 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1949,475,353 - 49,503,303 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0949,816,885 - 49,845,047 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0949,895,000 - 49,923,185 (+)NCBIUU_Cfam_GSD_1.0
Adamts13
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947199,894,464 - 199,925,811 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366693,456,494 - 3,478,512 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049366693,449,259 - 3,478,471 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAMTS13
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1273,024,009 - 273,056,039 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11273,022,014 - 273,066,916 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21306,995,806 - 307,029,855 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADAMTS13
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1124,677,237 - 4,718,825 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl124,677,229 - 4,714,386 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666058270,510 - 311,999 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adamts13
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247601,865,376 - 1,889,203 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247601,865,474 - 1,889,394 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adamts13
169 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:132
Count of miRNA genes:110
Interacting mature miRNAs:118
Transcripts:ENSRNOT00000007640, ENSRNOT00000070873
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3865816227494778Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 5 5 1 5
Low 2 7 44 36 36 1 1 1 5 15 11 1
Below cutoff 1 32 8 18 6 9 46 20 25 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000007640   ⟹   ENSRNOP00000007640
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl310,300,028 - 10,346,687 (+)Ensembl
Rnor_6.0 Ensembl35,519,990 - 5,558,166 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000070873   ⟹   ENSRNOP00000064846
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl310,300,028 - 10,333,018 (+)Ensembl
Rnor_6.0 Ensembl35,519,990 - 5,551,707 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000087635
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl34,893,872 - 4,897,116 (+)Ensembl
RefSeq Acc Id: XM_006233879   ⟹   XP_006233941
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2310,299,368 - 10,338,464 (+)NCBI
Rnor_6.035,519,921 - 5,558,390 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039106131   ⟹   XP_038962059
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2310,299,363 - 10,338,240 (+)NCBI
RefSeq Acc Id: XM_039106132   ⟹   XP_038962060
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2310,299,368 - 10,338,240 (+)NCBI
RefSeq Acc Id: XM_039106133   ⟹   XP_038962061
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2310,299,391 - 10,338,240 (+)NCBI
RefSeq Acc Id: XM_039106134   ⟹   XP_038962062
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2310,299,377 - 10,338,240 (+)NCBI
RefSeq Acc Id: XM_039106135   ⟹   XP_038962063
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2310,299,404 - 10,338,240 (+)NCBI
RefSeq Acc Id: XM_039106136   ⟹   XP_038962064
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2310,299,271 - 10,338,240 (+)NCBI
RefSeq Acc Id: XM_039106137   ⟹   XP_038962065
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2310,299,367 - 10,338,464 (+)NCBI
RefSeq Acc Id: XM_039106138   ⟹   XP_038962066
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2310,299,264 - 10,338,240 (+)NCBI
RefSeq Acc Id: XM_039106139   ⟹   XP_038962067
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2310,306,188 - 10,338,240 (+)NCBI
RefSeq Acc Id: XM_039106140   ⟹   XP_038962068
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2310,299,365 - 10,331,774 (+)NCBI
RefSeq Acc Id: XM_039106141   ⟹   XP_038962069
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2310,323,119 - 10,338,240 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_006233941   ⟸   XM_006233879
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000064846   ⟸   ENSRNOT00000070873
RefSeq Acc Id: ENSRNOP00000007640   ⟸   ENSRNOT00000007640
RefSeq Acc Id: XP_038962066   ⟸   XM_039106138
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038962064   ⟸   XM_039106136
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038962059   ⟸   XM_039106131
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038962068   ⟸   XM_039106140
- Peptide Label: isoform X9
RefSeq Acc Id: XP_038962065   ⟸   XM_039106137
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038962060   ⟸   XM_039106132
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038962062   ⟸   XM_039106134
- Peptide Label: isoform X4
- UniProtKB: D4A0T9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962061   ⟸   XM_039106133
- Peptide Label: isoform X4
- UniProtKB: D4A0T9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962063   ⟸   XM_039106135
- Peptide Label: isoform X4
- UniProtKB: D4A0T9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962067   ⟸   XM_039106139
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038962069   ⟸   XM_039106141
- Peptide Label: isoform X10
Protein Domains
Peptidase M12B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A0T9-F1-model_v2 AlphaFold D4A0T9 1-1425 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691921
Promoter ID:EPDNEW_R2445
Type:multiple initiation site
Name:Adamts13_1
Description:ADAM metallopeptidase with thrombospondin type 1 motif, 13
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.035,519,946 - 5,520,006EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311594 AgrOrtholog
BioCyc Gene G2FUF-50315 BioCyc
Ensembl Genes ENSRNOG00000005780 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000061920 Ensembl
Ensembl Protein ENSRNOP00000007640 ENTREZGENE
  ENSRNOP00000007640.6 UniProtKB/TrEMBL
  ENSRNOP00000064846 ENTREZGENE
  ENSRNOP00000064846.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007640 ENTREZGENE
  ENSRNOT00000007640.9 UniProtKB/TrEMBL
  ENSRNOT00000070873 ENTREZGENE
  ENSRNOT00000070873.2 UniProtKB/TrEMBL
Gene3D-CATH 2.20.100.10 UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/TrEMBL
InterPro ADAM_CR_2 UniProtKB/TrEMBL
  ADAMTS/ADAMTS-like UniProtKB/TrEMBL
  ADAMTS_CR_3 UniProtKB/TrEMBL
  ADAMTS_spacer1 UniProtKB/TrEMBL
  MetalloPept_cat_dom UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/TrEMBL
  sperma_CUB_dom UniProtKB/TrEMBL
  Thrombospondin_1_rpt UniProtKB/TrEMBL
  TSP1_rpt_sf UniProtKB/TrEMBL
KEGG Report rno:102554393 UniProtKB/TrEMBL
NCBI Gene Adamts13 ENTREZGENE
Pfam ADAM_CR_2 UniProtKB/TrEMBL
  ADAM_CR_3 UniProtKB/TrEMBL
  ADAM_spacer1 UniProtKB/TrEMBL
  Reprolysin UniProtKB/TrEMBL
  TSP_1 UniProtKB/TrEMBL
PhenoGen Adamts13 PhenoGen
PRINTS ADAMTSFAMILY UniProtKB/TrEMBL
PROSITE ADAM_MEPRO UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
SMART TSP1 UniProtKB/TrEMBL
Superfamily-SCOP CUB UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
UniProt D4A0T9 ENTREZGENE, UniProtKB/TrEMBL
  M0R609_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Adamts13  ADAM metallopeptidase with thrombospondin type 1 motif, 13  LOC102554283  A disintegrin and metalloproteinase with thrombospondin motifs 13-like  Data Merged 737654 PROVISIONAL
2015-07-21 Adamts13  ADAM metallopeptidase with thrombospondin type 1 motif, 13  LOC102554393  A disintegrin and metalloproteinase with thrombospondin motifs 13-like  Data Merged 737654 APPROVED
2013-12-18 LOC102554283  A disintegrin and metalloproteinase with thrombospondin motifs 13-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2013-12-17 LOC102554393  A disintegrin and metalloproteinase with thrombospondin motifs 13-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-09-18 Adamts13  ADAM metallopeptidase with thrombospondin type 1 motif, 13  Adamts13  a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Adamts13  a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13   Adamts13_predicted  a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Adamts13_predicted  a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13 (predicted)    a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 13 (predicted)  Name updated 1299863 APPROVED
2005-01-12 Adamts13_predicted  a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 13 (predicted)      Symbol and Name status set to approved 70820 APPROVED