Ctsz (cathepsin Z) - Rat Genome Database

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Gene: Ctsz (cathepsin Z) Rattus norvegicus
Analyze
Symbol: Ctsz
Name: cathepsin Z
RGD ID: 708479
Description: Predicted to enable carboxypeptidase activity and cysteine-type endopeptidase activity. Involved in negative regulation of neuron projection development; positive regulation of neural precursor cell proliferation; and positive regulation of neuron apoptotic process. Located in several cellular components, including cell surface; extracellular space; and growth cone. Orthologous to human CTSZ (cathepsin Z); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',5,5'-tetrabromobisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cathepsin X; cathepsin Y; CATX; LOC252929
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23163,224,875 - 163,235,645 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3163,224,875 - 163,235,645 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3167,023,616 - 167,034,386 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03175,520,073 - 175,530,842 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03173,264,462 - 173,275,232 (-)NCBIRnor_WKY
Rnor_6.03172,527,107 - 172,537,877 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3172,527,107 - 172,537,877 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03178,574,619 - 178,585,389 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera3162,398,362 - 162,409,134 (-)NCBICelera
Cytogenetic Map3q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Differential expression of Cathepsin S and X in the spinal cord of a rat neuropathic pain model. Leichsenring A, etal., BMC Neurosci. 2008 Aug 12;9:80.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Determination of the mRNA sequence of cathepsin Y, a cysteine endopeptidase from rat spleen, 1 and confirmation of its ubiquitous expression. Nakazono E, etal., Biol Chem 2002 Dec;383(12):1971-5.
5. Cathepsin X cleaves the C-terminal dipeptide of alpha- and gamma-enolase and impairs survival and neuritogenesis of neuronal cells. Obermajer N, etal., Int J Biochem Cell Biol. 2009 Aug-Sep;41(8-9):1685-96. doi: 10.1016/j.biocel.2009.02.019. Epub 2009 Mar 6.
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Cathepsin Y (a novel thiol enzyme) produces kinin potentiating peptide from the component protein of rat plasma. Sakamoto E, etal., Immunopharmacology 1999 Dec;45(1-3):207-14.
Additional References at PubMed
PMID:12477932   PMID:17500053   PMID:20551380   PMID:23376485   PMID:23533145  


Genomics

Comparative Map Data
Ctsz
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23163,224,875 - 163,235,645 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3163,224,875 - 163,235,645 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3167,023,616 - 167,034,386 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03175,520,073 - 175,530,842 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03173,264,462 - 173,275,232 (-)NCBIRnor_WKY
Rnor_6.03172,527,107 - 172,537,877 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3172,527,107 - 172,537,877 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03178,574,619 - 178,585,389 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera3162,398,362 - 162,409,134 (-)NCBICelera
Cytogenetic Map3q43NCBI
CTSZ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382058,995,185 - 59,007,254 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2058,985,686 - 59,008,238 (-)EnsemblGRCh38hg38GRCh38
GRCh372057,570,240 - 57,582,309 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362057,003,635 - 57,015,697 (-)NCBINCBI36Build 36hg18NCBI36
Build 342057,003,634 - 57,015,680NCBI
Celera2054,310,657 - 54,322,736 (-)NCBICelera
Cytogenetic Map20q13.32NCBI
HuRef2054,357,148 - 54,369,230 (-)NCBIHuRef
CHM1_12057,471,631 - 57,483,697 (-)NCBICHM1_1
T2T-CHM13v2.02060,778,286 - 60,790,364 (-)NCBIT2T-CHM13v2.0
Ctsz
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392174,269,287 - 174,280,832 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2174,269,286 - 174,280,832 (-)EnsemblGRCm39 Ensembl
GRCm382174,427,494 - 174,439,039 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2174,427,493 - 174,439,039 (-)EnsemblGRCm38mm10GRCm38
MGSCv372174,252,995 - 174,264,493 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362174,070,433 - 174,081,931 (-)NCBIMGSCv36mm8
Celera2180,388,324 - 180,399,730 (-)NCBICelera
Cytogenetic Map2H4NCBI
cM Map297.94NCBI
Ctsz
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955445586,902 - 597,753 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955445586,901 - 597,753 (+)NCBIChiLan1.0ChiLan1.0
CTSZ
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12056,706,511 - 56,718,941 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2056,706,511 - 56,718,941 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02055,346,241 - 55,358,354 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CTSZ
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12443,743,291 - 43,750,154 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2443,743,294 - 43,754,424 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2442,989,417 - 42,996,868 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02444,609,433 - 44,616,884 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2444,609,441 - 44,620,531 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12443,712,987 - 43,720,434 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02443,831,671 - 43,839,127 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02444,491,470 - 44,498,960 (-)NCBIUU_Cfam_GSD_1.0
Ctsz
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640181,815,540 - 181,824,209 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365301,482,012 - 1,490,736 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365301,482,007 - 1,490,685 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CTSZ
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1759,138,621 - 59,149,377 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11759,141,497 - 59,149,377 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21766,511,905 - 66,519,788 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CTSZ
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.125,135,729 - 5,146,063 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl25,135,770 - 5,145,630 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605053,186,955 - 53,197,273 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ctsz
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474125,280,916 - 25,301,800 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474125,280,916 - 25,301,724 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ctsz
20 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:66
Count of miRNA genes:52
Interacting mature miRNAs:59
Transcripts:ENSRNOT00000072069
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3145925360166177555Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3145925360166177555Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3145925360166177555Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3145925360166177555Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3145925360166177555Rat
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3145925360166177555Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145925360166177555Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3145956084169034231Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3149040888168026850Rat
1300161Rf10Renal function QTL 103.57renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)3161192952169034231Rat

Markers in Region
RH130740  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23163,224,497 - 163,224,698 (+)MAPPERmRatBN7.2
Rnor_6.03172,526,730 - 172,526,930NCBIRnor6.0
Rnor_5.03178,574,242 - 178,574,442UniSTSRnor5.0
Celera3162,397,985 - 162,398,185UniSTS
RH 3.4 Map31496.8UniSTS
AA818798  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23163,225,050 - 163,225,230 (+)MAPPERmRatBN7.2
Rnor_6.03172,527,283 - 172,527,462NCBIRnor6.0
Rnor_5.03178,574,795 - 178,574,974UniSTSRnor5.0
Celera3162,398,538 - 162,398,717UniSTS
RH 3.4 Map31496.9UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 36 57 41 19 41 1 4 66 33 34 11 1
Low 7 7 7 8 2 7 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000072069   ⟹   ENSRNOP00000066523
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3163,224,875 - 163,235,645 (-)Ensembl
Rnor_6.0 Ensembl3172,527,107 - 172,537,877 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000110056   ⟹   ENSRNOP00000087446
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3163,224,875 - 163,231,804 (-)Ensembl
RefSeq Acc Id: NM_183330   ⟹   NP_899159
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23163,224,875 - 163,235,645 (-)NCBI
Rnor_6.03172,527,107 - 172,537,877 (-)NCBI
Rnor_5.03178,574,619 - 178,585,389 (-)NCBI
Celera3162,398,362 - 162,409,134 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_899159 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH91110 (Get FASTA)   NCBI Sequence Viewer  
  BAA82844 (Get FASTA)   NCBI Sequence Viewer  
  EDL85083 (Get FASTA)   NCBI Sequence Viewer  
  EDL85084 (Get FASTA)   NCBI Sequence Viewer  
  Q9R1T3 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_899159   ⟸   NM_183330
- Peptide Label: precursor
- UniProtKB: Q5BKD9 (UniProtKB/Swiss-Prot),   Q9R1T3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000066523   ⟸   ENSRNOT00000072069
RefSeq Acc Id: ENSRNOP00000087446   ⟸   ENSRNOT00000110056
Protein Domains
Pept_C1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R1T3-F1-model_v2 AlphaFold Q9R1T3 1-306 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692721
Promoter ID:EPDNEW_R3245
Type:initiation region
Name:Ctsz_1
Description:cathepsin Z
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03172,537,883 - 172,537,943EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708479 AgrOrtholog
BioCyc Gene G2FUF-46452 BioCyc
Ensembl Genes ENSRNOG00000050697 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000066523 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000087446.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000072069 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000110056.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7379777 IMAGE-MGC_LOAD
InterPro Cathepsin_X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Papain-like_cys_pep_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_asp_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C1A_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:252929 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108536 IMAGE-MGC_LOAD
NCBI Gene 252929 ENTREZGENE
PANTHER PTHR12411:SF569 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Peptidase_C1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ctsz PhenoGen
PRINTS PAPAIN UniProtKB/Swiss-Prot
PROSITE THIOL_PROTEASE_ASN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Pept_C1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54001 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6GG04_RAT UniProtKB/TrEMBL
  CATZ_RAT UniProtKB/Swiss-Prot
  Q5BKD9 ENTREZGENE
  Q9R1T3 ENTREZGENE
UniProt Secondary Q5BKD9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-07-08 Ctsz  cathepsin Z  LOC252929  cathepsin Y  Symbol and Name updated 1299863 APPROVED