CTSZ (cathepsin Z) - Rat Genome Database

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Gene: CTSZ (cathepsin Z) Canis lupus familiaris
Analyze
Symbol: CTSZ
Name: cathepsin Z
RGD ID: 12368038
Description: ENCODES a protein that exhibits carboxypeptidase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN epithelial tube branching involved in lung morphogenesis (inferred); negative regulation of plasminogen activation (inferred); proteolysis (inferred); ASSOCIATED WITH acute myeloid leukemia (ortholog); amyotrophic lateral sclerosis type 8 (ortholog); COVID-19 (ortholog); FOUND IN cell surface (ortholog); growth cone (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12443,743,291 - 43,750,154 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2443,743,294 - 43,754,424 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2442,989,417 - 42,996,868 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02444,609,433 - 44,616,884 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2444,609,441 - 44,620,531 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12443,712,987 - 43,720,434 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02443,831,671 - 43,839,127 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02444,491,470 - 44,498,960 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
CTSZ
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12443,743,291 - 43,750,154 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2443,743,294 - 43,754,424 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2442,989,417 - 42,996,868 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02444,609,433 - 44,616,884 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2444,609,441 - 44,620,531 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12443,712,987 - 43,720,434 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02443,831,671 - 43,839,127 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02444,491,470 - 44,498,960 (-)NCBIUU_Cfam_GSD_1.0
CTSZ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382058,995,185 - 59,007,254 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2058,985,686 - 59,008,238 (-)EnsemblGRCh38hg38GRCh38
GRCh372057,570,240 - 57,582,309 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362057,003,635 - 57,015,697 (-)NCBINCBI36Build 36hg18NCBI36
Build 342057,003,634 - 57,015,680NCBI
Celera2054,310,657 - 54,322,736 (-)NCBICelera
Cytogenetic Map20q13.32NCBI
HuRef2054,357,148 - 54,369,230 (-)NCBIHuRef
CHM1_12057,471,631 - 57,483,697 (-)NCBICHM1_1
T2T-CHM13v2.02060,778,286 - 60,790,364 (-)NCBIT2T-CHM13v2.0
Ctsz
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392174,269,287 - 174,280,832 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2174,269,286 - 174,280,832 (-)EnsemblGRCm39 Ensembl
GRCm382174,427,494 - 174,439,039 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2174,427,493 - 174,439,039 (-)EnsemblGRCm38mm10GRCm38
MGSCv372174,252,995 - 174,264,493 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362174,070,433 - 174,081,931 (-)NCBIMGSCv36mm8
Celera2180,388,324 - 180,399,730 (-)NCBICelera
Cytogenetic Map2H4NCBI
cM Map297.94NCBI
Ctsz
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83183,643,077 - 183,653,847 (-)NCBIGRCr8
mRatBN7.23163,224,875 - 163,235,645 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3163,224,875 - 163,235,645 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3167,023,616 - 167,034,386 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03175,520,073 - 175,530,842 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03173,264,462 - 173,275,232 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03172,527,107 - 172,537,877 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3172,527,107 - 172,537,877 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03178,574,619 - 178,585,389 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera3162,398,362 - 162,409,134 (-)NCBICelera
Cytogenetic Map3q43NCBI
Ctsz
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955445586,902 - 597,753 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955445586,901 - 597,753 (+)NCBIChiLan1.0ChiLan1.0
CTSZ
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22164,758,586 - 64,770,698 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12064,751,705 - 64,763,824 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02055,346,241 - 55,358,354 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12056,706,511 - 56,718,941 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2056,706,511 - 56,718,941 (-)Ensemblpanpan1.1panPan2
Ctsz
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640181,815,540 - 181,824,209 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365301,482,012 - 1,490,736 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365301,482,007 - 1,490,685 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CTSZ
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1759,138,621 - 59,149,377 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11759,141,497 - 59,149,377 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21766,511,905 - 66,519,788 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CTSZ
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.125,135,729 - 5,146,063 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl25,135,770 - 5,145,630 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605053,186,955 - 53,197,273 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ctsz
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474125,280,916 - 25,301,800 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474125,280,916 - 25,301,724 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CTSZ
117 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000019357   ⟹   ENSCAFP00000017955
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2443,743,294 - 43,754,424 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000067171   ⟹   ENSCAFP00000047997
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2443,743,526 - 43,751,532 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845025140   ⟹   ENSCAFP00845019771
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2444,609,441 - 44,616,896 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845025157   ⟹   ENSCAFP00845019787
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2444,609,635 - 44,620,531 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845025181   ⟹   ENSCAFP00845019802
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2444,609,635 - 44,616,884 (-)Ensembl
RefSeq Acc Id: XM_038434235   ⟹   XP_038290163
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02444,609,433 - 44,616,884 (-)NCBI
RefSeq Acc Id: XM_038457730   ⟹   XP_038313658
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha2442,989,417 - 42,996,868 (-)NCBI
RefSeq Acc Id: XM_038509393   ⟹   XP_038365321
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12443,712,987 - 43,720,434 (-)NCBI
RefSeq Acc Id: XM_038572737   ⟹   XP_038428665
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02444,491,470 - 44,498,960 (-)NCBI
RefSeq Acc Id: XM_038637016   ⟹   XP_038492944
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02443,831,671 - 43,839,127 (-)NCBI
Ensembl Acc Id: ENSCAFP00000017955   ⟸   ENSCAFT00000019357
Ensembl Acc Id: ENSCAFP00000047997   ⟸   ENSCAFT00000067171
RefSeq Acc Id: XP_038365321   ⟸   XM_038509393
RefSeq Acc Id: XP_038492944   ⟸   XM_038637016
RefSeq Acc Id: XP_038290163   ⟸   XM_038434235
- UniProtKB: A0A8C0L900 (UniProtKB/TrEMBL),   A0A8I3S0K4 (UniProtKB/TrEMBL),   A0A8C0P1W5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038313658   ⟸   XM_038457730
- UniProtKB: A0A8C0L900 (UniProtKB/TrEMBL),   A0A8I3S0K4 (UniProtKB/TrEMBL),   A0A8C0P1W5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038428665   ⟸   XM_038572737
- UniProtKB: A0A8C0L900 (UniProtKB/TrEMBL),   A0A8C0P1W5 (UniProtKB/TrEMBL),   A0A8I3S0K4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845019802   ⟸   ENSCAFT00845025181
Ensembl Acc Id: ENSCAFP00845019787   ⟸   ENSCAFT00845025157
Ensembl Acc Id: ENSCAFP00845019771   ⟸   ENSCAFT00845025140
Protein Domains
Peptidase C1A papain C-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000012183 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030018986 UniProtKB/TrEMBL
  ENSCAFG00040019678 UniProtKB/TrEMBL
  ENSCAFG00845014050 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000019357.5 UniProtKB/TrEMBL
  ENSCAFT00000067171.2 UniProtKB/TrEMBL
  ENSCAFT00000100202.1 UniProtKB/TrEMBL
  ENSCAFT00000102443.1 UniProtKB/TrEMBL
  ENSCAFT00000104247.1 UniProtKB/TrEMBL
  ENSCAFT00030034891.1 UniProtKB/TrEMBL
  ENSCAFT00040036552.1 UniProtKB/TrEMBL
  ENSCAFT00040036630.1 UniProtKB/TrEMBL
  ENSCAFT00845025140 ENTREZGENE
  ENSCAFT00845025140.1 UniProtKB/TrEMBL
  ENSCAFT00845025157.1 UniProtKB/TrEMBL
  ENSCAFT00845025181.1 UniProtKB/TrEMBL
Gene3D-CATH Cysteine proteinases UniProtKB/TrEMBL
InterPro CTSZ UniProtKB/TrEMBL
  Papain-like_cys_pep_sf UniProtKB/TrEMBL
  Pept_asp_AS UniProtKB/TrEMBL
  Peptidase_C1A UniProtKB/TrEMBL
  Peptidase_C1A_C UniProtKB/TrEMBL
NCBI Gene CTSZ ENTREZGENE
PANTHER CATHEPSIN Z UniProtKB/TrEMBL
  CYSTEINE PROTEASE FAMILY C1-RELATED UniProtKB/TrEMBL
Pfam Peptidase_C1 UniProtKB/TrEMBL
PRINTS PAPAIN UniProtKB/TrEMBL
PROSITE THIOL_PROTEASE_ASN UniProtKB/TrEMBL
SMART Pept_C1 UniProtKB/TrEMBL
Superfamily-SCOP SSF54001 UniProtKB/TrEMBL
UniProt A0A8C0L900 ENTREZGENE
  A0A8C0P1W5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0T549_CANLF UniProtKB/TrEMBL
  A0A8C0T5A9_CANLF UniProtKB/TrEMBL
  A0A8I3NS39_CANLF UniProtKB/TrEMBL
  A0A8I3NT46_CANLF UniProtKB/TrEMBL
  A0A8I3S0K4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0NE53_CANLF UniProtKB/TrEMBL
  A0A8P0T0V7_CANLF UniProtKB/TrEMBL
  A0A8P0TUD5_CANLF UniProtKB/TrEMBL
UniProt Secondary A0A8P0PPM2 UniProtKB/TrEMBL
VGNC ID VGNC:39717 ENTREZGENE