CTSZ (cathepsin Z) - Rat Genome Database

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Gene: CTSZ (cathepsin Z) Sus scrofa
Analyze
Symbol: CTSZ
Name: cathepsin Z
RGD ID: 13999589
Description: ENCODES a protein that exhibits carboxypeptidase activity (inferred); cysteine-type endopeptidase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN epithelial tube branching involved in lung morphogenesis (inferred); negative regulation of plasminogen activation (inferred); proteolysis (inferred); ASSOCIATED WITH acute myeloid leukemia (ortholog); COVID-19 (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cell surface (ortholog); growth cone (ortholog); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: PROVISIONAL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1759,138,621 - 59,149,377 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11759,141,497 - 59,149,377 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21766,511,905 - 66,519,788 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:19496772   PMID:30032202  


Genomics

Comparative Map Data
CTSZ
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1759,138,621 - 59,149,377 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11759,141,497 - 59,149,377 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21766,511,905 - 66,519,788 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CTSZ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382058,995,185 - 59,007,254 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2058,985,686 - 59,008,238 (-)EnsemblGRCh38hg38GRCh38
GRCh372057,570,240 - 57,582,309 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362057,003,635 - 57,015,697 (-)NCBINCBI36Build 36hg18NCBI36
Build 342057,003,634 - 57,015,680NCBI
Celera2054,310,657 - 54,322,736 (-)NCBICelera
Cytogenetic Map20q13.32NCBI
HuRef2054,357,148 - 54,369,230 (-)NCBIHuRef
CHM1_12057,471,631 - 57,483,697 (-)NCBICHM1_1
T2T-CHM13v2.02060,778,286 - 60,790,364 (-)NCBIT2T-CHM13v2.0
Ctsz
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392174,269,287 - 174,280,832 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2174,269,286 - 174,280,832 (-)EnsemblGRCm39 Ensembl
GRCm382174,427,494 - 174,439,039 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2174,427,493 - 174,439,039 (-)EnsemblGRCm38mm10GRCm38
MGSCv372174,252,995 - 174,264,493 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362174,070,433 - 174,081,931 (-)NCBIMGSCv36mm8
Celera2180,388,324 - 180,399,730 (-)NCBICelera
Cytogenetic Map2H4NCBI
cM Map297.94NCBI
Ctsz
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83183,643,077 - 183,653,847 (-)NCBIGRCr8
mRatBN7.23163,224,875 - 163,235,645 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3163,224,875 - 163,235,645 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3167,023,616 - 167,034,386 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03175,520,073 - 175,530,842 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03173,264,462 - 173,275,232 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03172,527,107 - 172,537,877 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3172,527,107 - 172,537,877 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03178,574,619 - 178,585,389 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera3162,398,362 - 162,409,134 (-)NCBICelera
Cytogenetic Map3q43NCBI
Ctsz
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955445586,902 - 597,753 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955445586,901 - 597,753 (+)NCBIChiLan1.0ChiLan1.0
CTSZ
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22164,758,586 - 64,770,698 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12064,751,705 - 64,763,824 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02055,346,241 - 55,358,354 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12056,706,511 - 56,718,941 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2056,706,511 - 56,718,941 (-)Ensemblpanpan1.1panPan2
CTSZ
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12443,743,291 - 43,750,154 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2443,743,294 - 43,754,424 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2442,989,417 - 42,996,868 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02444,609,433 - 44,616,884 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2444,609,441 - 44,620,531 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12443,712,987 - 43,720,434 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02443,831,671 - 43,839,127 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02444,491,470 - 44,498,960 (-)NCBIUU_Cfam_GSD_1.0
Ctsz
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640181,815,540 - 181,824,209 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365301,482,012 - 1,490,736 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365301,482,007 - 1,490,685 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CTSZ
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.125,135,729 - 5,146,063 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl25,135,770 - 5,145,630 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605053,186,955 - 53,197,273 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ctsz
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474125,280,916 - 25,301,800 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474125,280,916 - 25,301,724 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CTSZ
239 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 8 3 5 2 1 3
Low 2 1 3 2 23 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000008249   ⟹   ENSSSCP00000008030
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1759,141,501 - 59,149,298 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000091896   ⟹   ENSSSCP00000078181
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1759,141,491 - 59,149,377 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000099736   ⟹   ENSSSCP00000076682
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1759,142,940 - 59,149,377 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000100945   ⟹   ENSSSCP00000079955
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1759,138,621 - 59,149,377 (-)Ensembl
RefSeq Acc Id: NM_001123104   ⟹   NP_001116576
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11759,141,497 - 59,149,377 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001116576   ⟸   NM_001123104
- Peptide Label: precursor
- UniProtKB: A5GFX7 (UniProtKB/TrEMBL),   A0A4X1UVH7 (UniProtKB/TrEMBL),   A0A8D1CAY0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000008030   ⟸   ENSSSCT00000008249
RefSeq Acc Id: ENSSSCP00000078181   ⟸   ENSSSCT00000091896
RefSeq Acc Id: ENSSSCP00000079955   ⟸   ENSSSCT00000100945
RefSeq Acc Id: ENSSSCP00000076682   ⟸   ENSSSCT00000099736
Protein Domains
Peptidase C1A papain C-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000007522 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025054501 UniProtKB/TrEMBL
  ENSSSCG00030049223 UniProtKB/TrEMBL
  ENSSSCG00035026790 UniProtKB/TrEMBL
  ENSSSCG00040038393 UniProtKB/TrEMBL
  ENSSSCG00045033055 UniProtKB/TrEMBL
  ENSSSCG00050023775 UniProtKB/TrEMBL
  ENSSSCG00055013866 UniProtKB/TrEMBL
  ENSSSCG00060039081 UniProtKB/TrEMBL
  ENSSSCG00065039366 UniProtKB/TrEMBL
  ENSSSCG00070019760 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000008249 ENTREZGENE
  ENSSSCT00000008249.3 UniProtKB/TrEMBL
  ENSSSCT00000091896.1 UniProtKB/TrEMBL
  ENSSSCT00000099736.1 UniProtKB/TrEMBL
  ENSSSCT00000100945.1 UniProtKB/TrEMBL
  ENSSSCT00025074516.1 UniProtKB/TrEMBL
  ENSSSCT00030068661.1 UniProtKB/TrEMBL
  ENSSSCT00035035364.1 UniProtKB/TrEMBL
  ENSSSCT00040051355.1 UniProtKB/TrEMBL
  ENSSSCT00045056446.1 UniProtKB/TrEMBL
  ENSSSCT00050032067.1 UniProtKB/TrEMBL
  ENSSSCT00055027320.1 UniProtKB/TrEMBL
  ENSSSCT00060052835.1 UniProtKB/TrEMBL
  ENSSSCT00065053814.1 UniProtKB/TrEMBL
  ENSSSCT00070039117.1 UniProtKB/TrEMBL
  ENSSSCT00070039129.1 UniProtKB/TrEMBL
Gene3D-CATH Cysteine proteinases UniProtKB/TrEMBL
InterPro Cathepsin_X UniProtKB/TrEMBL
  Papain_like_cys_pep_sf UniProtKB/TrEMBL
  Pept_asp_AS UniProtKB/TrEMBL
  Peptidase_C1A UniProtKB/TrEMBL
  Peptidase_C1A_C UniProtKB/TrEMBL
KEGG Report ssc:100141405 UniProtKB/TrEMBL
NCBI Gene CTSZ ENTREZGENE
PANTHER CATHEPSIN Z UniProtKB/TrEMBL
  CYSTEINE PROTEASE FAMILY C1-RELATED UniProtKB/TrEMBL
Pfam Peptidase_C1 UniProtKB/TrEMBL
PRINTS PAPAIN UniProtKB/TrEMBL
PROSITE THIOL_PROTEASE_ASN UniProtKB/TrEMBL
SMART Pept_C1 UniProtKB/TrEMBL
Superfamily-SCOP SSF54001 UniProtKB/TrEMBL
UniProt A0A4X1UVH7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1CAY0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8W4FBP0_PIG UniProtKB/TrEMBL
  A0A8W4FH28_PIG UniProtKB/TrEMBL
  A0A8W4FNS6_PIG UniProtKB/TrEMBL
  A5GFX7 ENTREZGENE, UniProtKB/TrEMBL
  B3LDT2_PIG UniProtKB/TrEMBL
  B3LDT3_PIG UniProtKB/TrEMBL
VGNC ID VGNC:96084 ENTREZGENE