Lrrc8e (leucine rich repeat containing 8 VRAC subunit E)

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Gene: Lrrc8e (leucine rich repeat containing 8 VRAC subunit E) Rattus norvegicus

Analyze

Symbol:

Lrrc8e

Name:

leucine rich repeat containing 8 VRAC subunit E

RGD ID:

1311979

Description:

Predicted to contribute to volume-sensitive anion channel activity. Predicted to be involved in several processes, including cell volume homeostasis; monoatomic anion transmembrane transport; and organic anion transport. Predicted to be located in endoplasmic reticulum membrane; lysosomal membrane; and plasma membrane. Predicted to be part of ion channel complex. Orthologous to human LRRC8E (leucine rich repeat containing 8 VRAC subunit E); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

leucine rich repeat containing 8 family, member E; leucine-rich repeat-containing protein 8E; LOC304203; MGC124693; RGD1311979; volume-regulated anion channel subunit LRRC8E

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	12	2,578,240 - 2,589,407 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	2,578,315 - 2,589,412 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	3,226,163 - 3,237,359 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	12	3,849,752 - 3,860,950 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	12	2,612,632 - 2,624,059 (+)	NCBI	Rnor_WKY
Rnor_6.0	12	2,557,267 - 2,568,416 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	2,557,275 - 2,568,382 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	4,710,039 - 4,721,300 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	1,554,464 - 1,566,012 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	12	1,554,997 - 1,566,044 (-)	NCBI
Celera	12	4,393,851 - 4,404,933 (+)	NCBI		Celera
Cytogenetic Map	12	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

familial hemophagocytic lymphohistiocytosis 5 (ISO)

genetic disease (ISO)

long QT syndrome (ISO)

mucolipidosis type IV (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2-hydroxypropanoic acid (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

bisphenol A (EXP)

cadmium dichloride (EXP)

choline (ISO)

coumestrol (ISO)

cyclosporin A (ISO)

dorsomorphin (ISO)

entinostat (ISO)

flutamide (EXP)

folic acid (ISO)

fulvestrant (ISO)

furan (EXP)

gentamycin (EXP)

glycidol (EXP)

hydralazine (ISO)

ivermectin (ISO)

L-methionine (ISO)

lidocaine (EXP)

lipopolysaccharide (ISO)

menadione (ISO)

methimazole (EXP)

panobinostat (ISO)

paracetamol (EXP,ISO)

rac-lactic acid (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium dodecyl sulfate (ISO)

sodium fluoride (ISO)

temozolomide (ISO)

tetrachloromethane (EXP)

trichostatin A (ISO)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

aspartate transmembrane transport (ISO,ISS)

cell volume homeostasis (ISO,ISS)

cellular response to osmotic stress (ISO,ISS)

cyclic-GMP-AMP transmembrane import across plasma membrane (ISO,ISS)

monoatomic anion transmembrane transport (ISO,ISS)

Cellular Component

cytoplasm (ISO,ISS)

endoplasmic reticulum membrane (ISO)

lysosomal membrane (ISO,ISS)

monoatomic ion channel complex (ISO,ISS)

obsolete integral component of endoplasmic reticulum membrane (ISO)

obsolete integral component of lysosomal membrane (ISO)

plasma membrane (ISO,ISS)

Molecular Function

protein binding (ISO)

volume-sensitive anion channel activity (ISO,ISS)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:15489334	PMID:22871113	PMID:24790029	PMID:26824658	PMID:28193731

Genomics

Comparative Map Data

Lrrc8e
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	12	2,578,240 - 2,589,407 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	2,578,315 - 2,589,412 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	3,226,163 - 3,237,359 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	12	3,849,752 - 3,860,950 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	12	2,612,632 - 2,624,059 (+)	NCBI	Rnor_WKY
Rnor_6.0	12	2,557,267 - 2,568,416 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	2,557,275 - 2,568,382 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	4,710,039 - 4,721,300 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	1,554,464 - 1,566,012 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	12	1,554,997 - 1,566,044 (-)	NCBI
Celera	12	4,393,851 - 4,404,933 (+)	NCBI		Celera
Cytogenetic Map	12	p12	NCBI

LRRC8E
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	7,888,510 - 7,902,016 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	19	7,888,505 - 7,902,021 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	7,953,395 - 7,966,901 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	7,859,390 - 7,872,907 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	19	7,824,591 - 7,838,110 (+)	NCBI		Celera
Cytogenetic Map	19	p13.2	NCBI
HuRef	19	7,623,841 - 7,637,152 (+)	NCBI		HuRef
CHM1_1	19	7,952,868 - 7,966,380 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	7,889,464 - 7,902,971 (+)	NCBI		T2T-CHM13v2.0

Lrrc8e
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	4,274,269 - 4,287,470 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	4,276,827 - 4,287,470 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	4,224,268 - 4,237,470 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	4,226,827 - 4,237,470 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	4,226,827 - 4,237,470 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	4,226,827 - 4,236,898 (+)	NCBI		MGSCv36	mm8
Celera	8	4,416,312 - 4,438,059 (+)	NCBI		Celera
Cytogenetic Map	8	A1.1	NCBI

Lrrc8e
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955563	1,362,266 - 1,370,226 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955563	1,362,266 - 1,370,221 (-)	NCBI	ChiLan1.0	ChiLan1.0

LRRC8E
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	19	8,041,185 - 8,055,684 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	8,041,185 - 8,055,684 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	19	7,189,490 - 7,203,310 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

LRRC8E
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	52,585,636 - 52,593,207 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	52,588,973 - 52,593,214 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	52,388,171 - 52,395,753 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	53,113,833 - 53,121,423 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	53,113,855 - 53,120,403 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	52,317,074 - 52,324,699 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	52,761,721 - 52,769,297 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	52,993,083 - 53,000,668 (+)	NCBI		UU_Cfam_GSD_1.0

Lrrc8e
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	212,954,121 - 212,961,388 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936588	4,873,412 - 4,880,533 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936588	4,873,412 - 4,880,574 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LRRC8E
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	71,309,402 - 71,314,701 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	71,309,404 - 71,318,225 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	71,710,888 - 71,718,616 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LRRC8E
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	7,337,918 - 7,351,914 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	7,346,243 - 7,351,855 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666081	462,397 - 474,514 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lrrc8e
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624828	860,744 - 868,595 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624828	859,419 - 868,595 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Lrrc8e
48 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	297
Count of miRNA genes:	189
Interacting mature miRNAs:	224
Transcripts:	ENSRNOT00000035142
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300174	Bw15	Body weight QTL 15	2.93		body mass (VT:0001259)	body weight loss (CMO:0001399)	12	1	9318387	Rat
2312418	Kidm41	Kidney mass QTL 41	3.7	0.0001	kidney mass (VT:0002707)	single kidney wet weight to body weight ratio (CMO:0000622)	12	1	19611090	Rat
10755457	Coatc14	Coat color QTL 14		0.01759	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	12	1	22591684	Rat
6893681	Bw109	Body weight QTL 109	2.3	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	12	1	23297788	Rat
1581516	Cm56	Cardiac mass QTL 56	4.2	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	12	1	29333307	Rat
1598855	Bp294	Blood pressure QTL 294	3.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	1	34851688	Rat
7411660	Foco28	Food consumption QTL 28	10.9	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
9590086	Insglur6	Insulin/glucose ratio QTL 6	18.97	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	12	1	42110980	Rat
8694179	Bw150	Body weight QTL 150	2.9	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	12	1	42110980	Rat
7411586	Foco5	Food consumption QTL 5	5.4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
7411595	Foco9	Food consumption QTL 9	4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
7411545	Bw128	Body weight QTL 128	5.2	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	12	1	42110980	Rat
9590147	Scort7	Serum corticosterone level QTL 7	13.61	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	12	1	42110980	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	1	42450532	Rat
737979	Pia22	Pristane induced arthritis QTL 22	53.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	1	44465750	Rat
634351	Apr5	Acute phase response QTL 5	6.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	12	1	44503507	Rat
2302042	Pia38	Pristane induced arthritis QTL 38	3.5	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	12	1	44503507	Rat
7243862	Mcs30	Mammary carcinoma susceptibility QTL 30	8.62		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	12	797729	8525593	Rat
634350	Apr4	Acute phase response QTL 4	6		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	1172005	46172005	Rat

Markers in Region

RH131894

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Celera	12	4,404,790 - 4,404,939	UniSTS
Cytogenetic Map	12	p12	UniSTS

UniSTS:235828

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_5.0	12	4,712,549 - 4,712,771	NCBI	Rnor5.0
Rnor_5.0	7	84,220,191 - 84,220,413	NCBI	Rnor5.0
RGSC_v3.4	7	81,194,021 - 81,194,242	UniSTS	RGSC3.4
RGSC_v3.4	12	1,556,967 - 1,557,188	UniSTS	RGSC3.4
Cytogenetic Map	12	p12	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	1									15	2
Low	2	2	19	6	5	6	1	1	2	20	37	11	1
Below cutoff		38	34	31	14	31	7	9	64		2		7

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001034139	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006248763	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006248764	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008768954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089309	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089310	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089311	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC105779	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474084	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000223	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000035142 ⟹ ENSRNOP00000037487

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	2,578,315 - 2,589,412 (+)	Ensembl
Rnor_6.0 Ensembl	12	2,557,275 - 2,568,382 (-)	Ensembl

RefSeq Acc Id:

NM_001034139 ⟹ NP_001029311

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	12	2,578,299 - 2,589,399 (+)	NCBI
Rnor_6.0	12	2,557,275 - 2,568,382 (-)	NCBI
Rnor_5.0	12	4,710,039 - 4,721,300 (-)	NCBI
RGSC_v3.4	12	1,554,464 - 1,566,012 (-)	RGD
Celera	12	4,393,851 - 4,404,933 (+)	RGD

Sequence:

show sequence

GCGGGAGTCCGGGTCCATCTACTCCCAGTGATCTAGGAGTTGGGCCCCAGAGTTCCATCCCAGA
GCAACAGGATGATCCCAGTGGCGGAGTTCAAGCAGTTCACGGAGCAGCAGCCTGCGTTCAAGGT
GCTCAAACCCTGGTGGGATGTTTTGGCTGAGTACCTCACTGTGGCTATGCTCATGATTGGGGTG
TTCGGGTGCACCCTCCAGGTGACACAGGACAAGATCATCTGCCTGCCCAGCCATGAATCTCGTG
AGAACTCATCAGAGGCTCCTTGCCAGCAGCTGTTGCCTCAAGGGATCTCTGAGCAGATTGGAGG
CCTACGAGAGCTCAGCGGCCTCAAGAATAACCTAGACCTCCAGCAATACAGCTTTATTAACCAG
CTCTGCTATGAGACTGCCCTCCACTGGTACGCCAAGTACTTCCCCTACCTGGTGGTCATTCATA
CTCTTATCTTTATGGTCTGTACCAGCTTTTGGTTCAAATTCCCTGGTACCAGCTCCAAAATAGA
ACACTTCATCTCTATCCTGGGCAAGTGTTTCGACTCTCCGTGGACCACTCGGGCCTTGTCTGAG
GTGTCTGGAGAAAATCACAAGGGCCCAGCTGCTGGACGGGCCACGGTGACCACAGTAACCACGG
TGGGGACAGGGACAGGGAAGGTGGGCGAGGGTGAGAAGGAGAAAGTGCTGATAGAGCCTGAGAA
GGTGGTGACTGAACCCCCAGCTGTAACCCTGCTGGATAAGAAGGAGGGCGAACAAGCTAAGGCC
CTATTTGAGAAGGTCAAAAAGTTCCGAGTGCACGTGGAAGAGGGTGACATCCTCTACTCCATGT
ACATCCGGCAGACGGTGCTCAAAGTGTGTAAGTTTTTTGCCATCCTGGTTTACAACCTGGTCTA
TGTGGAGAAGATCAGCTTTCTGGTGGCCTGTAGGGTGGAGACATCAGAGATCACAGGCTACGCC
AGTTTCTGCTGCAACCACACCAAGGCCCACCTCTTTTCTAAGCTGGCCTTCTGCTACATCTCCT
TCGTGTGTGTCTATGGCATCACCTGCCTGTACACGCTCTACTGGCTCTTCCACAGGCCCCTTAA
AGAGTACTCCTTCCGTTCTGTGCGGGAGGAGACAGGGATGAATGATATCCCGGATGTTAGGAAT
GACTTCGCCTTCATGCTCCACCTCATTGACCAGTATGACTCCCTCTATTCTAAACGGTTTGCAG
TCTTCCTCTCTGAAGTCAGTGAAAGCCGCCTTAAGCAGCTCAACCTCAACCACGAGTGGACACC
TGATAAGCTGAGGCAGAAGCTGCAGCGTAACGCACGCGGTCGGCTGGAGCTGAGCCTCTGTATG
CTCCCTGGGCTTCCGGACACTGTCTTTGAGCTCAGTGAGGTAGAGGCGCTCAGACTGGAGGCCA
TCTGCGACATCTCCTTTCCACCAGGGCTATCCCAGCTCGTGAACCTTCAGGAGCTCAGCCTGCT
TCACTCACCAGCCAGGCTGCCCTTCTCTTCACAGATCTTCCTGCGAGACCGGCTGAAAGTGATC
TGTGTCAAGTTTGAGGAGCTCCGCGAGGTACCCCTCTGGGTGTTTGGGCTCCGAGGCTTGGAAG
AACTACACCTGGAAGGACTCTTCCCCCCAGAAATGGCTCGGGGTGCCACCCTCGAGAGCCTCCG
GGAGCTTAAACAGCTCAAGGTACTGTCTCTCCGTAGCAATGCAGGGAAGGTGCCAGCCAGCGTG
ACCGATGTAGCCGGGCACCTTCAGCGACTCAGCCTGCACAATGATGGCGCTCGTCTGCTCGCCT
TAAACAGCCTCAAGAAGCTGGCGGTGTTACGGGAGCTGGAGCTGGTGGCCTGTGGGCTGGAACG
TATCCCCCATGCAATCTTCAGCCTGGGGGCTCTGCAGGAACTCGACCTTAAGGACAACCACCTC
CGGTCTATTGAGGAGATCCTCAGCTTCCAGCACTGTCGGAAGCTGGTCATTCTCAGGCTGTGGC
ACAACCAGATAGCCTATGTGCCTGAGCATGTGAGGAAGCTCCGAAGCCTGGAGCAGCTCTACCT
CAGTCACAACAAGCTTGAGACTCTGCCTGCCCAGCTTGGCCAGTGCTTTGGCCTCCGCCTGCTG
GATGTGTCCCACAACGGGCTTCGTTCCCTGCCACCTGAGTTGGGTCTTCTCCAGAGTCTCCAGC
ATCTAGCCCTCTCCTACAACGCACTTGAGAGCCTGCCTGATGAACTGTTCTTCTGCCATAAGCT
GCGGACATTACTCTTGGGCTACAACCACCTGACTCAGTTTTCGCCCCACGTGGCTGCCCTTCAG
GCCCTCAGCCGTCTGGAGCTCAAGGGTAACAGGTTGGAGGCACTGCCAGAAGAACTCGGTGACT
GCAAGGGGCTGAAAAAGTCAGGGCTCCTGGTGGAGGACACCCTTTATGAGGGGCTGCCTGCAGA
GGTTCGGGAGAAAATGGAAGAGGAATGAAGCCTCTTGGGGAACGGGGCAGGATGACAGAGAGGC
CTTTATGTTTCTGCCCCAACGTTGTATTACAAGGGAGCTGGGTCCAGCAGGAGTGGGAGGCAGG
CCAGACATGTCGGTTTTGTGCAGCTCAGACGAGATCCTGGGACTGGTTTGTCTGGGGGAGAAAC
AGGAGGTGGTGGATTTGGGGTGTAACGCCTTAGGGAAGGATTAACTCAGTCCTAGGTTCTTCAA
CCAAAACCACACCTGTGTCTTTGGCTGGTTGGCTCTTCCTCTAAACATTCCAGCTTAGTTAGTT
TCCTATACAGGAGTGGGGGACACATCCCAATGGGATTTCCAACCCTTCCAGCAACGATCAACAT
ATATTTAAGGAGAAGAGGACACAGGGTCCACTTCCGAAGTTCTGTATCCCAACTTTAATGCCAA
GTCCTTATGTTATAAGCTCTTTGTCACAGGGATGGGTACTTAGAACAATGGTTCTCACATGTGG
CTATGTAATTAAATCAGCAGAAGGGCCCGGAAGAAAATAAAACCTTTACACGATTCAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006248763 ⟹ XP_006248825

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	12	2,578,248 - 2,589,407 (+)	NCBI
Rnor_6.0	12	2,557,267 - 2,568,416 (-)	NCBI
Rnor_5.0	12	4,710,039 - 4,721,300 (-)	NCBI

Sequence:

show sequence

CTGACTCACCCTCTCTGGCCCGCCCGGGAACTCTGCGGGAGTCCGGGTCCATCTACTCCCAGTG
ATCTAGGAGTTGGGCCCCAGAGTTCCATCCCAGAGCAGTGAACAGGATGATCCCAGTGGCGGAG
TTCAAGCAGTTCACGGAGCAGCAGCCTGCGTTCAAGGTGCTCAAACCCTGGTGGGATGTTTTGG
CTGAGTACCTCACTGTGGCTATGCTCATGATTGGGGTGTTCGGGTGCACCCTCCAGGTGACACA
GGACAAGATCATCTGCCTGCCCAGCCATGAATCTCGTGAGAACTCATCAGAGGCTCCTTGCCAG
CAGCTGTTGCCTCAAGGGATCTCTGAGCAGATTGGAGGCCTACGAGAGCTCAGCGGCCTCAAGA
ATAACCTAGACCTCCAGCAATACAGCTTTATTAACCAGCTCTGCTATGAGACTGCCCTCCACTG
GTACGCCAAGTACTTCCCCTACCTGGTGGTCATTCATACTCTTATCTTTATGGTCTGTACCAGC
TTTTGGTTCAAATTCCCTGGTACCAGCTCCAAAATAGAACACTTCATCTCTATCCTGGGCAAGT
GTTTCGACTCTCCGTGGACCACTCGGGCCTTGTCTGAGGTGTCTGGAGAAAATCACAAGGGCCC
AGCTGCTGGACGGGCCACGGTGACCACAGTAACCACGGTGGGGACAGGGACAGGGAAGGTGGGC
GAGGGTGAGAAGGAGAAAGTGCTGATAGAGCCTGAGAAGGTGGTGACTGAACCCCCAGCTGTAA
CCCTGCTGGATAAGAAGGAGGGCGAACAAGCTAAGGCCCTATTTGAGAAGGTCAAAAAGTTCCG
AGTGCACGTGGAAGAGGGTGACATCCTCTACTCCATGTACATCCGGCAGACGGTGCTCAAAGTG
TGTAAGTTTTTTGCCATCCTGGTTTACAACCTGGTCTATGTGGAGAAGATCAGCTTTCTGGTGG
CCTGTAGGGTGGAGACATCAGAGATCACAGGCTACGCCAGTTTCTGCTGCAACCACACCAAGGC
CCACCTCTTTTCTAAGCTGGCCTTCTGCTACATCTCCTTCGTGTGTGTCTATGGCATCACCTGC
CTGTACACGCTCTACTGGCTCTTCCACAGGCCCCTTAAAGAGTACTCCTTCCGTTCTGTGCGGG
AGGAGACAGGGATGAATGATATCCCGGATGTTAGGAATGACTTCGCCTTCATGCTCCACCTCAT
TGACCAGTATGACTCCCTCTATTCTAAACGGTTTGCAGTCTTCCTCTCTGAAGTCAGTGAAAGC
CGCCTTAAGCAGCTCAACCTCAACCACGAGTGGACACCTGATAAGCTGAGGCAGAAGCTGCAGC
GTAACGCACGCGGTCGGCTGGAGCTGAGCCTCTGTATGCTCCCTGGGCTTCCGGACACTGTCTT
TGAGCTCAGTGAGGTAGAGGCGCTCAGACTGGAGGCCATCTGCGACATCTCCTTTCCACCAGGG
CTATCCCAGCTCGTGAACCTTCAGGAGCTCAGCCTGCTTCACTCACCAGCCAGGCTGCCCTTCT
CTTCACAGATCTTCCTGCGAGACCGGCTGAAAGTGATCTGTGTCAAGTTTGAGGAGCTCCGCGA
GGTACCCCTCTGGGTGTTTGGGCTCCGAGGCTTGGAAGAACTACACCTGGAAGGACTCTTCCCC
CCAGAAATGGCTCGGGGTGCCACCCTCGAGAGCCTCCGGGAGCTTAAACAGCTCAAGGTACTGT
CTCTTCGTAGCAATGCAGGGAAGGTGCCAGCCAGCGTGACCGATGTAGCCGGGCACCTTCAGCG
ACTCAGCCTGCACAATGATGGCGCTCGTCTGCTCGCCTTAAACAGCCTCAAGAAGCTGGCGGTG
TTACGGGAGCTGGAGCTGGTGGCCTGTGGGCTGGAACGTATCCCCCATGCAATCTTCAGCCTGG
GGGCTCTGCAGGAACTCGACCTTAAGGACAACCACCTCCGGTCTATTGAGGAGATCCTCAGCTT
CCAGCACTGTCGGAAGCTGGTCATTCTCAGGCTGTGGCACAACCAGATAGCCTATGTGCCTGAG
CATGTGAGGAAGCTCCGAAGCCTGGAGCAGCTCTACCTCAGTCACAACAAGCTTGAGACTCTGC
CTGCCCAGCTTGGCCAGTGCTTTGGCCTCCGCCTGCTGGATGTGTCCCACAACGGGCTTCGTTC
CCTGCCACCTGAGTTGGGTCTTCTCCAGAGTCTCCAGCATCTAGCCCTCTCCTACAACGCACTT
GAGAGCCTGCCTGATGAACTGTTCTTCTGCCATAAGCTGCGGACATTACTCTTGGGCTACAACC
ACCTGACTCAGTTTTCGCCCCACGTGGCTGCCCTTCAGGCCCTCAGCCGTCTGGAGCTCAAGGG
TAACAGGTTGGAGGCACTGCCAGAAGAACTCGGTGACTGCAAGGGGCTGAAAAAGTCAGGGCTC
CTGGTGGAGGACACCCTTTATGAGGGGCTGCCTGCAGAGGTTCGGGAGAAAATGGAAGAGGAAT
GAAGCCTCTTGGGGAACGGGGCAGGATGACAGAGAGGCCTTTATGTTTCTGCCCCAACGTTGTA
TTACAAGGGAGCTGGGTCCAGCAGGAGTGGGAGGCAGGCCAGACATGTCGGTTTTGTGCAGCTC
AGACGAGATCCTGGGACTGGTTTGTCTGGGGGAGAAACAGGAGGTGGTGGATTTGGGGTGTAAC
GCCTTAGGGAAGGATTAACTCAGTCCTAGGTTCTTCAACCAAAACCACACCTGTGTCTTTGGCT
GGTTGGCTCTTCCTCTAAACATTCCAGCTTAGTTAGTTTCCTATACAGGAGTGGGGGACACATC
CCAATGGGATTTCCAACCCTTCCAGCAACGATCAACATATATTTAAGGAGAGGACACAGGGTCC
ACTTCCGAAGTTCTGTATCCCAACTTTAATGCCAAGTCCTTATGTTATAAGCTCTTTGTCACAG
GGATGGGTACTTAGAACAATGGTTCTCACATGTGGCTATGTAATTAAATCAGCAGAAGGGCCCG
GAAGAAAATAAAACCTTTACACGATTCCCACCCCA

hide sequence

RefSeq Acc Id:

XM_006248764 ⟹ XP_006248826

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	12	2,578,249 - 2,589,407 (+)	NCBI
Rnor_6.0	12	2,557,267 - 2,568,416 (-)	NCBI
Rnor_5.0	12	4,710,039 - 4,721,300 (-)	NCBI

Sequence:

show sequence

CTGACTCACCCTCTCTGGCCCGCCCGGGAACTCTGCGGGAGTCCGGGTCCATCTACTCCCAGTG
ATCTAGGAGTTGGGCCCCAGAGTTCCATCCCAGAGCAGTGAAGGCAGGCAGCCAGAGGAGGAGA
CCGGAGGACAGCTGTCCTGTGTTTTTACCCTCACGGGTTCTGAGAAGGCAGGCAGTGAGAGATA
AAACAGCGCTTTGGAGACGGGGAAACACTGTGAGATTGGGAAAGAGACAGGATGATCCCAGTGG
CGGAGTTCAAGCAGTTCACGGAGCAGCAGCCTGCGTTCAAGGTGCTCAAACCCTGGTGGGATGT
TTTGGCTGAGTACCTCACTGTGGCTATGCTCATGATTGGGGTGTTCGGGTGCACCCTCCAGGTG
ACACAGGACAAGATCATCTGCCTGCCCAGCCATGAATCTCGTGAGAACTCATCAGAGGCTCCTT
GCCAGCAGCTGTTGCCTCAAGGGATCTCTGAGCAGATTGGAGGCCTACGAGAGCTCAGCGGCCT
CAAGAATAACCTAGACCTCCAGCAATACAGCTTTATTAACCAGCTCTGCTATGAGACTGCCCTC
CACTGGTACGCCAAGTACTTCCCCTACCTGGTGGTCATTCATACTCTTATCTTTATGGTCTGTA
CCAGCTTTTGGTTCAAATTCCCTGGTACCAGCTCCAAAATAGAACACTTCATCTCTATCCTGGG
CAAGTGTTTCGACTCTCCGTGGACCACTCGGGCCTTGTCTGAGGTGTCTGGAGAAAATCACAAG
GGCCCAGCTGCTGGACGGGCCACGGTGACCACAGTAACCACGGTGGGGACAGGGACAGGGAAGG
TGGGCGAGGGTGAGAAGGAGAAAGTGCTGATAGAGCCTGAGAAGGTGGTGACTGAACCCCCAGC
TGTAACCCTGCTGGATAAGAAGGAGGGCGAACAAGCTAAGGCCCTATTTGAGAAGGTCAAAAAG
TTCCGAGTGCACGTGGAAGAGGGTGACATCCTCTACTCCATGTACATCCGGCAGACGGTGCTCA
AAGTGTGTAAGTTTTTTGCCATCCTGGTTTACAACCTGGTCTATGTGGAGAAGATCAGCTTTCT
GGTGGCCTGTAGGGTGGAGACATCAGAGATCACAGGCTACGCCAGTTTCTGCTGCAACCACACC
AAGGCCCACCTCTTTTCTAAGCTGGCCTTCTGCTACATCTCCTTCGTGTGTGTCTATGGCATCA
CCTGCCTGTACACGCTCTACTGGCTCTTCCACAGGCCCCTTAAAGAGTACTCCTTCCGTTCTGT
GCGGGAGGAGACAGGGATGAATGATATCCCGGATGTTAGGAATGACTTCGCCTTCATGCTCCAC
CTCATTGACCAGTATGACTCCCTCTATTCTAAACGGTTTGCAGTCTTCCTCTCTGAAGTCAGTG
AAAGCCGCCTTAAGCAGCTCAACCTCAACCACGAGTGGACACCTGATAAGCTGAGGCAGAAGCT
GCAGCGTAACGCACGCGGTCGGCTGGAGCTGAGCCTCTGTATGCTCCCTGGGCTTCCGGACACT
GTCTTTGAGCTCAGTGAGGTAGAGGCGCTCAGACTGGAGGCCATCTGCGACATCTCCTTTCCAC
CAGGGCTATCCCAGCTCGTGAACCTTCAGGAGCTCAGCCTGCTTCACTCACCAGCCAGGCTGCC
CTTCTCTTCACAGATCTTCCTGCGAGACCGGCTGAAAGTGATCTGTGTCAAGTTTGAGGAGCTC
CGCGAGGTACCCCTCTGGGTGTTTGGGCTCCGAGGCTTGGAAGAACTACACCTGGAAGGACTCT
TCCCCCCAGAAATGGCTCGGGGTGCCACCCTCGAGAGCCTCCGGGAGCTTAAACAGCTCAAGGT
ACTGTCTCTTCGTAGCAATGCAGGGAAGGTGCCAGCCAGCGTGACCGATGTAGCCGGGCACCTT
CAGCGACTCAGCCTGCACAATGATGGCGCTCGTCTGCTCGCCTTAAACAGCCTCAAGAAGCTGG
CGGTGTTACGGGAGCTGGAGCTGGTGGCCTGTGGGCTGGAACGTATCCCCCATGCAATCTTCAG
CCTGGGGGCTCTGCAGGAACTCGACCTTAAGGACAACCACCTCCGGTCTATTGAGGAGATCCTC
AGCTTCCAGCACTGTCGGAAGCTGGTCATTCTCAGGCTGTGGCACAACCAGATAGCCTATGTGC
CTGAGCATGTGAGGAAGCTCCGAAGCCTGGAGCAGCTCTACCTCAGTCACAACAAGCTTGAGAC
TCTGCCTGCCCAGCTTGGCCAGTGCTTTGGCCTCCGCCTGCTGGATGTGTCCCACAACGGGCTT
CGTTCCCTGCCACCTGAGTTGGGTCTTCTCCAGAGTCTCCAGCATCTAGCCCTCTCCTACAACG
CACTTGAGAGCCTGCCTGATGAACTGTTCTTCTGCCATAAGCTGCGGACATTACTCTTGGGCTA
CAACCACCTGACTCAGTTTTCGCCCCACGTGGCTGCCCTTCAGGCCCTCAGCCGTCTGGAGCTC
AAGGGTAACAGGTTGGAGGCACTGCCAGAAGAACTCGGTGACTGCAAGGGGCTGAAAAAGTCAG
GGCTCCTGGTGGAGGACACCCTTTATGAGGGGCTGCCTGCAGAGGTTCGGGAGAAAATGGAAGA
GGAATGAAGCCTCTTGGGGAACGGGGCAGGATGACAGAGAGGCCTTTATGTTTCTGCCCCAACG
TTGTATTACAAGGGAGCTGGGTCCAGCAGGAGTGGGAGGCAGGCCAGACATGTCGGTTTTGTGC
AGCTCAGACGAGATCCTGGGACTGGTTTGTCTGGGGGAGAAACAGGAGGTGGTGGATTTGGGGT
GTAACGCCTTAGGGAAGGATTAACTCAGTCCTAGGTTCTTCAACCAAAACCACACCTGTGTCTT
TGGCTGGTTGGCTCTTCCTCTAAACATTCCAGCTTAGTTAGTTTCCTATACAGGAGTGGGGGAC
ACATCCCAATGGGATTTCCAACCCTTCCAGCAACGATCAACATATATTTAAGGAGAGGACACAG
GGTCCACTTCCGAAGTTCTGTATCCCAACTTTAATGCCAAGTCCTTATGTTATAAGCTCTTTGT
CACAGGGATGGGTACTTAGAACAATGGTTCTCACATGTGGCTATGTAATTAAATCAGCAGAAGG
GCCCGGAAGAAAATAAAACCTTTACACGATTCCCACCCCA

hide sequence

RefSeq Acc Id:

XM_039089309 ⟹ XP_038945237

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	12	2,578,240 - 2,589,407 (+)	NCBI

RefSeq Acc Id:

XM_039089310 ⟹ XP_038945238

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	12	2,578,249 - 2,589,407 (+)	NCBI

RefSeq Acc Id:

XM_039089311 ⟹ XP_038945239

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	12	2,578,256 - 2,589,407 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001029311	(Get FASTA)	NCBI Sequence Viewer
	XP_006248825	(Get FASTA)	NCBI Sequence Viewer
	XP_006248826	(Get FASTA)	NCBI Sequence Viewer
	XP_038945237	(Get FASTA)	NCBI Sequence Viewer
	XP_038945238	(Get FASTA)	NCBI Sequence Viewer
	XP_038945239	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI05780	(Get FASTA)	NCBI Sequence Viewer
	EDL74984	(Get FASTA)	NCBI Sequence Viewer
	Q3KRC6	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001029311 ⟸ NM_001034139

- UniProtKB:

Q3KRC6 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MIPVAEFKQFTEQQPAFKVLKPWWDVLAEYLTVAMLMIGVFGCTLQVTQDKIICLPSHESRENS
SEAPCQQLLPQGISEQIGGLRELSGLKNNLDLQQYSFINQLCYETALHWYAKYFPYLVVIHTLI
FMVCTSFWFKFPGTSSKIEHFISILGKCFDSPWTTRALSEVSGENHKGPAAGRATVTTVTTVGT
GTGKVGEGEKEKVLIEPEKVVTEPPAVTLLDKKEGEQAKALFEKVKKFRVHVEEGDILYSMYIR
QTVLKVCKFFAILVYNLVYVEKISFLVACRVETSEITGYASFCCNHTKAHLFSKLAFCYISFVC
VYGITCLYTLYWLFHRPLKEYSFRSVREETGMNDIPDVRNDFAFMLHLIDQYDSLYSKRFAVFL
SEVSESRLKQLNLNHEWTPDKLRQKLQRNARGRLELSLCMLPGLPDTVFELSEVEALRLEAICD
ISFPPGLSQLVNLQELSLLHSPARLPFSSQIFLRDRLKVICVKFEELREVPLWVFGLRGLEELH
LEGLFPPEMARGATLESLRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLLALNS
LKKLAVLRELELVACGLERIPHAIFSLGALQELDLKDNHLRSIEEILSFQHCRKLVILRLWHNQ
IAYVPEHVRKLRSLEQLYLSHNKLETLPAQLGQCFGLRLLDVSHNGLRSLPPELGLLQSLQHLA
LSYNALESLPDELFFCHKLRTLLLGYNHLTQFSPHVAALQALSRLELKGNRLEALPEELGDCKG
LKKSGLLVEDTLYEGLPAEVREKMEEE

hide sequence

RefSeq Acc Id:	XP_006248825 ⟸ XM_006248763
- Peptide Label:	isoform X1
- UniProtKB:	Q3KRC6 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MIPVAEFKQFTEQQPAFKVLKPWWDVLAEYLTVAMLMIGVFGCTLQVTQDKIICLPSHESRENS SEAPCQQLLPQGISEQIGGLRELSGLKNNLDLQQYSFINQLCYETALHWYAKYFPYLVVIHTLI FMVCTSFWFKFPGTSSKIEHFISILGKCFDSPWTTRALSEVSGENHKGPAAGRATVTTVTTVGT GTGKVGEGEKEKVLIEPEKVVTEPPAVTLLDKKEGEQAKALFEKVKKFRVHVEEGDILYSMYIR QTVLKVCKFFAILVYNLVYVEKISFLVACRVETSEITGYASFCCNHTKAHLFSKLAFCYISFVC VYGITCLYTLYWLFHRPLKEYSFRSVREETGMNDIPDVRNDFAFMLHLIDQYDSLYSKRFAVFL SEVSESRLKQLNLNHEWTPDKLRQKLQRNARGRLELSLCMLPGLPDTVFELSEVEALRLEAICD ISFPPGLSQLVNLQELSLLHSPARLPFSSQIFLRDRLKVICVKFEELREVPLWVFGLRGLEELH LEGLFPPEMARGATLESLRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLLALNS LKKLAVLRELELVACGLERIPHAIFSLGALQELDLKDNHLRSIEEILSFQHCRKLVILRLWHNQ IAYVPEHVRKLRSLEQLYLSHNKLETLPAQLGQCFGLRLLDVSHNGLRSLPPELGLLQSLQHLA LSYNALESLPDELFFCHKLRTLLLGYNHLTQFSPHVAALQALSRLELKGNRLEALPEELGDCKG LKKSGLLVEDTLYEGLPAEVREKMEEE hide sequence

RefSeq Acc Id:	XP_006248826 ⟸ XM_006248764
- Peptide Label:	isoform X1
- UniProtKB:	Q3KRC6 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MIPVAEFKQFTEQQPAFKVLKPWWDVLAEYLTVAMLMIGVFGCTLQVTQDKIICLPSHESRENS SEAPCQQLLPQGISEQIGGLRELSGLKNNLDLQQYSFINQLCYETALHWYAKYFPYLVVIHTLI FMVCTSFWFKFPGTSSKIEHFISILGKCFDSPWTTRALSEVSGENHKGPAAGRATVTTVTTVGT GTGKVGEGEKEKVLIEPEKVVTEPPAVTLLDKKEGEQAKALFEKVKKFRVHVEEGDILYSMYIR QTVLKVCKFFAILVYNLVYVEKISFLVACRVETSEITGYASFCCNHTKAHLFSKLAFCYISFVC VYGITCLYTLYWLFHRPLKEYSFRSVREETGMNDIPDVRNDFAFMLHLIDQYDSLYSKRFAVFL SEVSESRLKQLNLNHEWTPDKLRQKLQRNARGRLELSLCMLPGLPDTVFELSEVEALRLEAICD ISFPPGLSQLVNLQELSLLHSPARLPFSSQIFLRDRLKVICVKFEELREVPLWVFGLRGLEELH LEGLFPPEMARGATLESLRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLLALNS LKKLAVLRELELVACGLERIPHAIFSLGALQELDLKDNHLRSIEEILSFQHCRKLVILRLWHNQ IAYVPEHVRKLRSLEQLYLSHNKLETLPAQLGQCFGLRLLDVSHNGLRSLPPELGLLQSLQHLA LSYNALESLPDELFFCHKLRTLLLGYNHLTQFSPHVAALQALSRLELKGNRLEALPEELGDCKG LKKSGLLVEDTLYEGLPAEVREKMEEE hide sequence

RefSeq Acc Id:

ENSRNOP00000037487 ⟸ ENSRNOT00000035142

RefSeq Acc Id:	XP_038945237 ⟸ XM_039089309
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038945238 ⟸ XM_039089310
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038945239 ⟸ XM_039089311
- Peptide Label:	isoform X2

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q3KRC6-F1-model_v2	AlphaFold	Q3KRC6	1-795	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698384

Promoter ID:

EPDNEW_R8908

Type:

single initiation site

Name:

Lrrc8e_1

Description:

leucine rich repeat containing 8 VRAC subunit E

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	12	2,568,406 - 2,568,466	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311979	AgrOrtholog
BioCyc Gene	G2FUF-20353	BioCyc
Ensembl Genes	ENSRNOG00000028460	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSRNOP00000037487	ENTREZGENE
	ENSRNOP00000037487.3	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000035142	ENTREZGENE
	ENSRNOT00000035142.5	UniProtKB/Swiss-Prot
Gene3D-CATH	3.80.10.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7932319	IMAGE-MGC_LOAD
InterPro	Leu-rich_rpt	UniProtKB/Swiss-Prot
	Leu-rich_rpt_typical-subtyp	UniProtKB/Swiss-Prot
	LRR_dom_sf	UniProtKB/Swiss-Prot
	LRRC8_Pannexin-like	UniProtKB/Swiss-Prot
KEGG Report	rno:304203	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:124693	IMAGE-MGC_LOAD
NCBI Gene	304203	ENTREZGENE
PANTHER	PTHR48051	UniProtKB/Swiss-Prot
	VOLUME-REGULATED ANION CHANNEL SUBUNIT LRRC8C-LIKE	UniProtKB/Swiss-Prot
Pfam	LRR_8	UniProtKB/Swiss-Prot
	Pannexin_like	UniProtKB/Swiss-Prot
PhenoGen	Lrrc8e	PhenoGen
PROSITE	LRR	UniProtKB/Swiss-Prot
SMART	LRR_BAC	UniProtKB/Swiss-Prot
	LRR_TYP	UniProtKB/Swiss-Prot
Superfamily-SCOP	L domain-like	UniProtKB/Swiss-Prot
UniProt	LRC8E_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-08-16	Lrrc8e	leucine rich repeat containing 8 VRAC subunit E	Lrrc8e	leucine rich repeat containing 8 family, member E	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Lrrc8e	leucine rich repeat containing 8 family, member E	RGD1311979	similar to hypothetical protein	Symbol and Name updated	1299863	APPROVED
2005-12-06	RGD1311979	similar to hypothetical protein	RGD1311979_predicted	similar to hypothetical protein (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-20	RGD1311979_predicted	similar to hypothetical protein (predicted)	LOC304203_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC304203_predicted	similar to hypothetical protein (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar