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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Lrrc8e | Rat | (1->4)-beta-D-glucan | multiple interactions | ISO | Lrrc8e (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of LRRC8E mRNA | CTD | PMID:36331819 | Lrrc8e | Rat | 17beta-estradiol | increases expression | ISO | LRRC8E (Homo sapiens) | 6480464 | Estradiol results in increased expression of LRRC8E mRNA | CTD | PMID:20106945 | Lrrc8e | Rat | 2,3',4,4',5-Pentachlorobiphenyl | increases expression | ISO | Lrrc8e (Mus musculus) | 6480464 | 2,3',4,4',5-pentachlorobiphenyl results in increased expression of LRRC8E mRNA | CTD | PMID:31388691 | Lrrc8e | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of LRRC8E mRNA | CTD | PMID:33387578 | Lrrc8e | Rat | 2-hydroxypropanoic acid | decreases expression | ISO | LRRC8E (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of LRRC8E mRNA | CTD | PMID:30851411 | Lrrc8e | Rat | 4,4'-sulfonyldiphenol | multiple interactions | ISO | LRRC8E (Homo sapiens) | 6480464 | [bisphenol S co-treated with Fulvestrant] results in increased methylation of LRRC8E gene | CTD | PMID:31601247 | Lrrc8e | Rat | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of LRRC8E mRNA | CTD | PMID:22504374|PMID:24780913 | Lrrc8e | Rat | aflatoxin B1 | affects expression | ISO | LRRC8E (Homo sapiens) | 6480464 | Aflatoxin B1 affects the expression of LRRC8E protein | CTD | PMID:20106945 | Lrrc8e | Rat | aristolochic acid A | increases expression | ISO | LRRC8E (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of LRRC8E mRNA | CTD | PMID:33212167 | Lrrc8e | Rat | atrazine | increases expression | EXP | | 6480464 | Atrazine results in increased expression of LRRC8E mRNA | CTD | PMID:36841081 | Lrrc8e | Rat | benzo[a]pyrene | increases expression | ISO | LRRC8E (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of LRRC8E mRNA | CTD | PMID:20064835|PMID:20106945|PMID:21632981 | Lrrc8e | Rat | benzo[a]pyrene | increases methylation | ISO | LRRC8E (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of LRRC8E promoter | CTD | PMID:27901495 | Lrrc8e | Rat | benzo[a]pyrene | affects methylation | ISO | LRRC8E (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of LRRC8E 3' UTR; Benzo(a)pyrene affects the methylation of LRRC8E intron | CTD | PMID:27901495|PMID:30157460 | Lrrc8e | Rat | benzo[b]fluoranthene | increases expression | ISO | Lrrc8e (Mus musculus) | 6480464 | benzo(b)fluoranthene results in increased expression of LRRC8E mRNA | CTD | PMID:26377693 | Lrrc8e | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of LRRC8E mRNA | CTD | PMID:25181051 | Lrrc8e | Rat | cadmium dichloride | increases methylation | EXP | | 6480464 | Cadmium Chloride results in increased methylation of LRRC8E promoter | CTD | PMID:22457795 | Lrrc8e | Rat | cadmium dichloride | increases expression | ISO | LRRC8E (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of LRRC8E mRNA | CTD | PMID:38568856 | Lrrc8e | Rat | choline | multiple interactions | ISO | Lrrc8e (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression more ... | CTD | PMID:20938992 | Lrrc8e | Rat | coumestrol | decreases expression | ISO | LRRC8E (Homo sapiens) | 6480464 | Coumestrol results in decreased expression of LRRC8E mRNA | CTD | PMID:19167446 | Lrrc8e | Rat | cyclosporin A | increases expression | ISO | LRRC8E (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of LRRC8E mRNA | CTD | PMID:20106945 | Lrrc8e | Rat | dorsomorphin | multiple interactions | ISO | LRRC8E (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression more ... | CTD | PMID:27188386 | Lrrc8e | Rat | entinostat | increases expression | ISO | LRRC8E (Homo sapiens) | 6480464 | entinostat results in increased expression of LRRC8E mRNA | CTD | PMID:26272509|PMID:27188386 | Lrrc8e | Rat | entinostat | multiple interactions | ISO | LRRC8E (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression more ... | CTD | PMID:27188386 | Lrrc8e | Rat | flutamide | decreases expression | EXP | | 6480464 | Flutamide results in decreased expression of LRRC8E mRNA | CTD | PMID:24793618 | Lrrc8e | Rat | folic acid | multiple interactions | ISO | Lrrc8e (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression more ... | CTD | PMID:20938992 | Lrrc8e | Rat | fulvestrant | multiple interactions | ISO | LRRC8E (Homo sapiens) | 6480464 | [bisphenol S co-treated with Fulvestrant] results in increased methylation of LRRC8E gene | CTD | PMID:31601247 | Lrrc8e | Rat | furan | increases expression | EXP | | 6480464 | furan results in increased expression of LRRC8E mRNA | CTD | PMID:27387713 | Lrrc8e | Rat | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of LRRC8E mRNA | CTD | PMID:33387578 | Lrrc8e | Rat | glycidol | increases expression | EXP | | 6480464 | glycidol results in increased expression of LRRC8E mRNA | CTD | PMID:24395379 | Lrrc8e | Rat | hydralazine | multiple interactions | ISO | LRRC8E (Homo sapiens) | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of LRRC8E mRNA | CTD | PMID:17183730 | Lrrc8e | Rat | ivermectin | decreases expression | ISO | LRRC8E (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of LRRC8E protein | CTD | PMID:32959892 | Lrrc8e | Rat | L-methionine | multiple interactions | ISO | Lrrc8e (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression more ... | CTD | PMID:20938992 | Lrrc8e | Rat | lidocaine | increases expression | EXP | | 6480464 | Lidocaine results in increased expression of LRRC8E mRNA | CTD | PMID:35283115 | Lrrc8e | Rat | lipopolysaccharide | multiple interactions | ISO | LRRC8E (Homo sapiens) | 6480464 | [S-(1,2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in decreased expression of LRRC8E mRNA | CTD | PMID:35811015 | Lrrc8e | Rat | menadione | affects expression | ISO | LRRC8E (Homo sapiens) | 6480464 | Vitamin K 3 affects the expression of LRRC8E mRNA | CTD | PMID:20044591 | Lrrc8e | Rat | methimazole | increases expression | EXP | | 6480464 | Methimazole results in increased expression of LRRC8E mRNA | CTD | PMID:22504374 | Lrrc8e | Rat | okadaic acid | increases expression | ISO | LRRC8E (Homo sapiens) | 6480464 | Okadaic Acid results in increased expression of LRRC8E mRNA | CTD | PMID:38832940 | Lrrc8e | Rat | panobinostat | multiple interactions | ISO | LRRC8E (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression more ... | CTD | PMID:27188386 | Lrrc8e | Rat | panobinostat | increases expression | ISO | LRRC8E (Homo sapiens) | 6480464 | panobinostat results in increased expression of LRRC8E mRNA | CTD | PMID:26272509 | Lrrc8e | Rat | paracetamol | increases expression | ISO | LRRC8E (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of LRRC8E mRNA | CTD | PMID:26690555 | Lrrc8e | Rat | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of LRRC8E mRNA | CTD | PMID:33387578 | Lrrc8e | Rat | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Lrrc8e (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of LRRC8E mRNA | CTD | PMID:36331819 | Lrrc8e | Rat | rac-lactic acid | decreases expression | ISO | LRRC8E (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of LRRC8E mRNA | CTD | PMID:30851411 | Lrrc8e | Rat | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | LRRC8E (Homo sapiens) | 6480464 | [S-(1,2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in decreased expression of LRRC8E mRNA | CTD | PMID:35811015 | Lrrc8e | Rat | SB 431542 | multiple interactions | ISO | LRRC8E (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression more ... | CTD | PMID:27188386 | Lrrc8e | Rat | silicon dioxide | increases expression | ISO | LRRC8E (Homo sapiens) | 6480464 | Silicon Dioxide results in increased expression of LRRC8E mRNA | CTD | PMID:25351596 | Lrrc8e | Rat | sodium dodecyl sulfate | increases expression | ISO | LRRC8E (Homo sapiens) | 6480464 | Sodium Dodecyl Sulfate results in increased expression of LRRC8E mRNA | CTD | PMID:31734321 | Lrrc8e | Rat | sodium fluoride | increases expression | ISO | Lrrc8e (Mus musculus) | 6480464 | Sodium Fluoride results in increased expression of LRRC8E mRNA | CTD | PMID:27862939 | Lrrc8e | Rat | temozolomide | decreases expression | ISO | LRRC8E (Homo sapiens) | 6480464 | Temozolomide results in decreased expression of LRRC8E mRNA | CTD | PMID:31758290 | Lrrc8e | Rat | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of LRRC8E mRNA | CTD | PMID:31150632 | Lrrc8e | Rat | trichostatin A | increases expression | ISO | LRRC8E (Homo sapiens) | 6480464 | trichostatin A results in increased expression of LRRC8E mRNA | CTD | PMID:24935251 | Lrrc8e | Rat | urethane | increases expression | ISO | LRRC8E (Homo sapiens) | 6480464 | Urethane results in increased expression of LRRC8E mRNA | CTD | PMID:28818685 | Lrrc8e | Rat | valproic acid | increases methylation | ISO | LRRC8E (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of LRRC8E gene | CTD | PMID:29154799 | Lrrc8e | Rat | valproic acid | multiple interactions | ISO | LRRC8E (Homo sapiens) | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of LRRC8E mRNA | CTD | PMID:17183730 | Lrrc8e | Rat | valproic acid | increases expression | ISO | LRRC8E (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of LRRC8E mRNA | CTD | PMID:24935251 | |