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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dichloroethane | decreases expression | ISO | RGD:1557804 | 6480464 | ethylene dichloride results in decreased expression of TGIF2 mRNA | CTD | PMID:28960355 | 1,2-dimethylhydrazine | increases expression | ISO | RGD:1557804 | 6480464 | 1, 2-Dimethylhydrazine results in increased expression of TGIF2 mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:1557804 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TGIF2 mRNA | CTD | PMID:17942748 | 17beta-estradiol | increases expression | ISO | RGD:1344249 | 6480464 | Estradiol results in increased expression of TGIF2 mRNA | CTD | PMID:23019147 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1557804 | 6480464 | Tetrachlorodibenzodioxin affects the expression of TGIF2 mRNA | CTD | PMID:21570461, PMID:24058054 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of TGIF2 mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:1557804 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TGIF2 mRNA, Tetrachlorodibenzodioxin affects the reaction [AHR protein binds to TGIF2 promoter] | CTD | PMID:17942748, PMID:19654925 | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | RGD:1557804 | 6480464 | N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of TGIF2 mRNA | CTD | PMID:20188158 | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of TGIF2 mRNA | CTD | PMID:24780913 | acrylamide | increases expression | EXP | | 6480464 | Acrylamide results in increased expression of TGIF2 mRNA | CTD | PMID:28959563 | Aflatoxin B2 alpha | decreases methylation | ISO | RGD:1344249 | 6480464 | aflatoxin B2 results in decreased methylation of TGIF2 promoter | CTD | PMID:30157460 | all-trans-retinoic acid | decreases expression | ISO | RGD:1344249 | 6480464 | Tretinoin results in decreased expression of TGIF2 mRNA | CTD | PMID:33167477 | arsenite(3-) | increases methylation | ISO | RGD:1344249 | 6480464 | arsenite results in increased methylation of TGIF2 promoter | CTD | PMID:23974009 | benzo[a]pyrene | multiple interactions | ISO | RGD:1557804 | 6480464 | Benzo(a)pyrene affects the reaction [AHR protein binds to TGIF2 promoter] | CTD | PMID:19654925 | benzo[a]pyrene | affects methylation | ISO | RGD:1344249 | 6480464 | Benzo(a)pyrene affects the methylation of TGIF2 promoter | CTD | PMID:27901495 | benzo[a]pyrene | decreases expression | ISO | RGD:1557804 | 6480464 | Benzo(a)pyrene results in decreased expression of TGIF2 mRNA | CTD | PMID:21569818 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of TGIF2 mRNA | CTD | PMID:30816183, PMID:34947998 | cannabidiol | multiple interactions | ISO | RGD:1557804 | 6480464 | [lipopolysaccharide, E coli O55-B5 co-treated with Cannabidiol] results in decreased expression of TGIF2 mRNA | CTD | PMID:30742662 | choline | multiple interactions | ISO | RGD:1557804 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TGIF2 mRNA, [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TGIF2 gene | CTD | PMID:20938992 | copper atom | multiple interactions | ISO | RGD:1344249 | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of TGIF2 mRNA | CTD | PMID:20971185 | copper(0) | multiple interactions | ISO | RGD:1344249 | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of TGIF2 mRNA | CTD | PMID:20971185 | copper(II) sulfate | decreases expression | ISO | RGD:1344249 | 6480464 | Copper Sulfate results in decreased expression of TGIF2 mRNA | CTD | PMID:19549813 | coumestrol | multiple interactions | ISO | RGD:1344249 | 6480464 | [Coumestrol co-treated with 2 more ... | CTD | PMID:19167446 | coumestrol | increases expression | ISO | RGD:1344249 | 6480464 | Coumestrol results in increased expression of TGIF2 mRNA | CTD | PMID:19167446 | Cuprizon | increases expression | EXP | | 6480464 | Cuprizone results in increased expression of TGIF2 mRNA | CTD | PMID:26577399 | cyclosporin A | decreases expression | ISO | RGD:1344249 | 6480464 | Cyclosporine results in decreased expression of TGIF2 mRNA | CTD | PMID:25562108 | diazinon | increases methylation | ISO | RGD:1344249 | 6480464 | Diazinon results in increased methylation of TGIF2 gene | CTD | PMID:22964155 | dibutyl phthalate | decreases expression | ISO | RGD:1557804 | 6480464 | Dibutyl Phthalate results in decreased expression of TGIF2 mRNA | CTD | PMID:17361019 | dicrotophos | increases expression | ISO | RGD:1344249 | 6480464 | dicrotophos results in increased expression of TGIF2 mRNA | CTD | PMID:28302478 | dorsomorphin | multiple interactions | ISO | RGD:1344249 | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TGIF2 mRNA | CTD | PMID:27188386 | endosulfan | decreases expression | EXP | | 6480464 | Endosulfan results in decreased expression of TGIF2 mRNA | CTD | PMID:29391264 | Enterolactone | multiple interactions | ISO | RGD:1344249 | 6480464 | [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of TGIF2 mRNA | CTD | PMID:19167446 | etoposide | decreases expression | ISO | RGD:1557804 | 6480464 | Etoposide results in decreased expression of TGIF2 mRNA | CTD | PMID:25270620 | folic acid | multiple interactions | ISO | RGD:1557804 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TGIF2 mRNA, [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TGIF2 gene | CTD | PMID:20938992 | gentamycin | affects expression | EXP | | 6480464 | Gentamicins affects the expression of TGIF2 mRNA | CTD | PMID:33387578 | glyphosate | increases expression | ISO | RGD:1344249 | 6480464 | glyphosate results in increased expression of TGIF2 mRNA | CTD | PMID:31295307 | hydralazine | multiple interactions | ISO | RGD:1344249 | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of TGIF2 mRNA | CTD | PMID:17183730 | L-methionine | multiple interactions | ISO | RGD:1557804 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TGIF2 mRNA, [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TGIF2 gene | CTD | PMID:20938992 | lidocaine | increases expression | EXP | | 6480464 | Lidocaine results in increased expression of TGIF2 mRNA | CTD | PMID:35283115 | methotrexate | affects expression | ISO | RGD:1557804 | 6480464 | Methotrexate affects the expression of TGIF2 mRNA | CTD | PMID:18502557 | methyl methanesulfonate | decreases expression | ISO | RGD:1344249 | 6480464 | Methyl Methanesulfonate results in decreased expression of TGIF2 mRNA | CTD | PMID:23649840 | paracetamol | decreases expression | ISO | RGD:1344249 | 6480464 | Acetaminophen results in decreased expression of TGIF2 mRNA | CTD | PMID:22230336 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of TGIF2 mRNA | CTD | PMID:33387578 | perfluorononanoic acid | decreases expression | ISO | RGD:1344249 | 6480464 | perfluoro-n-nonanoic acid results in decreased expression of TGIF2 mRNA | CTD | PMID:25812627 | perfluorooctane-1-sulfonic acid | decreases expression | ISO | RGD:1344249 | 6480464 | perfluorooctane sulfonic acid results in decreased expression of TGIF2 mRNA | CTD | PMID:25812627 | perfluorooctanoic acid | decreases expression | ISO | RGD:1344249 | 6480464 | perfluorooctanoic acid results in decreased expression of TGIF2 mRNA | CTD | PMID:25812627 | phenylmercury acetate | decreases expression | ISO | RGD:1344249 | 6480464 | Phenylmercuric Acetate results in decreased expression of TGIF2 mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | RGD:1344249 | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TGIF2 mRNA | CTD | PMID:27188386 | pirinixic acid | increases expression | ISO | RGD:1557804 | 6480464 | pirinixic acid results in increased expression of TGIF2 mRNA | CTD | PMID:23811191 | quercetin | decreases expression | ISO | RGD:1344249 | 6480464 | Quercetin results in decreased expression of TGIF2 mRNA | CTD | PMID:21632981 | quercitrin | decreases expression | ISO | RGD:1344249 | 6480464 | quercitrin results in decreased expression of TGIF2 mRNA | CTD | PMID:25193878 | resveratrol | multiple interactions | ISO | RGD:1344249 | 6480464 | [Coumestrol co-treated with Resveratrol] results in increased expression of TGIF2 mRNA, [Plant Extracts co-treated with Resveratrol] results in decreased expression of TGIF2 mRNA | CTD | PMID:19167446, PMID:23557933 | rimonabant | multiple interactions | ISO | RGD:1557804 | 6480464 | Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of TGIF2 mRNA] | CTD | PMID:19030233 | SB 431542 | multiple interactions | ISO | RGD:1344249 | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TGIF2 mRNA | CTD | PMID:27188386 | temozolomide | increases expression | ISO | RGD:1344249 | 6480464 | Temozolomide results in increased expression of TGIF2 mRNA | CTD | PMID:31758290 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of TGIF2 mRNA | CTD | PMID:34492290 | trichloroethene | decreases expression | EXP | | 6480464 | Trichloroethylene results in decreased expression of TGIF2 mRNA | CTD | PMID:33387578 | trichostatin A | affects expression | ISO | RGD:1344249 | 6480464 | trichostatin A affects the expression of TGIF2 mRNA | CTD | PMID:28542535 | tungsten | increases expression | ISO | RGD:1557804 | 6480464 | Tungsten results in increased expression of TGIF2 mRNA | CTD | PMID:30912803 | uranium atom | affects expression | ISO | RGD:1344249 | 6480464 | Uranium affects the expression of TGIF2 mRNA | CTD | PMID:15672453 | urethane | decreases expression | ISO | RGD:1344249 | 6480464 | Urethane results in decreased expression of TGIF2 mRNA | CTD | PMID:28818685 | valproic acid | multiple interactions | ISO | RGD:1344249 | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of TGIF2 mRNA | CTD | PMID:17183730 | valproic acid | affects expression | ISO | RGD:1344249 | 6480464 | Valproic Acid affects the expression of TGIF2 mRNA | CTD | PMID:25979313 | valproic acid | decreases expression | ISO | RGD:1344249 | 6480464 | Valproic Acid results in decreased expression of TGIF2 mRNA | CTD | PMID:23179753 more ... | |