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Gene: Plp1 (proteolipid protein 1) Rattus norvegicus
Symbol: Plp1
Name: proteolipid protein 1
RGD ID: 3354
Description: A structural constituent of myelin sheath. Involved in several processes, including AMPA selective glutamate receptor signaling pathway; nervous system development; and positive regulation of calcium ion transmembrane transport. Localizes to integrin alphav-beta3 complex and myelin sheath. Used to study demyelinating disease and visual epilepsy. Human ortholog(s) of this gene implicated in Pelizaeus-Merzbacher disease and hereditary spastic paraplegia 2. Orthologous to human PLP1 (proteolipid protein 1); INTERACTS WITH 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol; 2,3-Dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: lipophilin; myelin proteolipid protein; Plp; proteolipid protein; proteolipid protein (myelin); proteolipid protein (myelin) 1; Proteolipid protein (Pelizaeus-Merzbacher disease spastic paraplegia 2 uncomplicated); Proteolipid protein (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated)
Homo sapiens (human) : PLP1 (proteolipid protein 1)  HGNC  Alliance
Mus musculus (house mouse) : Plp1 (proteolipid protein (myelin) 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Plp1 (proteolipid protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PLP1 (proteolipid protein 1)
Canis lupus familiaris (dog) : PLP1 (proteolipid protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Plp1 (proteolipid protein 1)
Sus scrofa (pig) : PLP1 (proteolipid protein 1)
Chlorocebus sabaeus (African green monkey) : PLP1 (proteolipid protein 1)
Heterocephalus glaber (naked mole-rat) : Plp1 (proteolipid protein 1)
more info ...
Allele / Splice: Plp1md  
Genetic Models: W-Plp1md/Nya
Is Marker For: Strains:   W-Plp1md/Nya  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0X107,494,326 - 107,511,355 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX107,496,072 - 107,511,348 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X107,379,831 - 107,394,881 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X124,488,627 - 124,503,639 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X124,562,059 - 124,577,072 (+)NCBI
CeleraX101,020,110 - 101,035,276 (+)NCBICelera
Cytogenetic MapXq32NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Plp1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3354
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.