Plp1 (proteolipid protein 1) - Rat Genome Database

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Gene: Plp1 (proteolipid protein 1) Rattus norvegicus
Analyze
Symbol: Plp1
Name: proteolipid protein 1
RGD ID: 3354
Description: A structural constituent of myelin sheath. Involved in several processes, including AMPA selective glutamate receptor signaling pathway; nervous system development; and positive regulation of calcium ion transmembrane transport. Located in myelin sheath. Part of integrin alphav-beta3 complex. Used to study demyelinating disease and visual epilepsy. Human ortholog(s) of this gene implicated in Pelizaeus-Merzbacher disease and hereditary spastic paraplegia 2. Orthologous to human PLP1 (proteolipid protein 1); INTERACTS WITH 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol; 2,3-Dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: lipophilin; myelin proteolipid protein; Plp; proteolipid protein; proteolipid protein (myelin); proteolipid protein (myelin) 1; Proteolipid protein (Pelizaeus-Merzbacher disease spastic paraplegia 2 uncomplicated); Proteolipid protein (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Plp1md  
Genetic Models: W-Plp1md/Nya
Is Marker For: Strains:   W-Plp1md/Nya  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X100,184,039 - 100,201,035 (+)NCBImRatBN7.2
mRatBN7.2 EnsemblX100,185,767 - 100,201,032 (+)Ensembl
Rnor_6.0X107,494,326 - 107,511,355 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX107,496,072 - 107,511,348 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X107,379,831 - 107,394,881 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X124,488,627 - 124,503,639 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X124,562,059 - 124,577,072 (+)NCBI
CeleraX101,020,110 - 101,035,276 (+)NCBICelera
Cytogenetic MapXq32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,4-trimethylbenzene  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3-Dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
alachlor  (EXP)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (EXP)
AMPA receptor agonist  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (EXP)
caffeine  (ISO)
capsaicin  (EXP)
carbofuran  (EXP)
carbon nanotube  (ISO)
chlordecone  (ISO)
chlorpyrifos  (EXP)
clozapine  (ISO)
cocaine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
Cuprizon  (EXP,ISO)
cycloheximide  (EXP)
cytarabine  (ISO)
dabigatran  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
etoposide  (ISO)
fenvalerate  (EXP)
genistein  (ISO)
haloperidol  (ISO)
hydrazine  (ISO)
hydrogen sulfide  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
lead diacetate  (EXP)
lidocaine  (EXP)
linagliptin  (ISO)
mechlorethamine  (ISO)
methylmercury chloride  (ISO)
mitomycin C  (ISO)
nickel atom  (ISO)
nitrofen  (EXP)
olanzapine  (ISO)
oxaliplatin  (EXP)
panobinostat  (ISO)
paraquat  (EXP)
PCB138  (EXP)
phencyclidine  (ISO)
phenylmercury acetate  (ISO)
progesterone  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
undecane  (EXP)
valproic acid  (ISO)
warfarin  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
premature death  (IAGP)
tremors  (IAGP)
References

References - curated
1. Boison D and Stoffel W, EMBO J 1989 Nov;8(11):3295-302.
2. Boucher SE, etal., J Neurosci 2002 Mar 1;22(5):1772-83.
3. Csiza CK and de Lahunta A, Am J Pathol 1979 Apr;95(1):215-23.
4. Dautigny A, etal., FEBS Lett 1985 Aug 19;188(1):33-6.
5. Duncan ID, etal., Proc Natl Acad Sci U S A 1987 Sep;84(17):6287-91.
6. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Gordon MN, etal., Int J Dev Neurosci 1992 Aug;10(4):243-53.
8. Gudz TI, etal., J Neurosci 2002 Sep 1;22(17):7398-407.
9. Gudz TI, etal., J Neurosci. 2006 Mar 1;26(9):2458-66. doi: 10.1523/JNEUROSCI.4054-05.2006.
10. Hudson LD J Child Neurol 2003 Sep;18(9):616-24.
11. MGD data from the GO Consortium
12. Milner RJ, etal., Cell 1985 Oct;42(3):931-9.
13. Nadon NL and Duncan ID, J Neurosci Res 1995 May 1;41(1):96-104.
14. NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. OMIM Disease Annotation Pipeline
16. Peacock JW, etal., Eur J Immunol. 2003 Jul;33(7):1849-58. doi: 10.1002/eji.200323148.
17. RGD automated data pipeline
18. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. RGD automated import pipeline for gene-chemical interactions
20. Schaich M, etal., Biol Chem Hoppe Seyler 1986 Aug;367(8):825-34.
21. Yamaguchi Y, etal., J Neurosci Res. 2008 Mar;86(4):766-75.
22. Yamamoto T and Nanba E, Hum Mutat 1999 Aug 19;14(2):182.
23. Zhu WH, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2014 May;34(5):562-5.
Additional References at PubMed
PMID:1150661   PMID:1373175   PMID:1689377   PMID:1694232   PMID:1702593   PMID:2432393   PMID:2441390   PMID:11746780   PMID:12477932   PMID:14169723   PMID:16288477   PMID:17634366  
PMID:17962415   PMID:19808102   PMID:20578039   PMID:21784154   PMID:22871113   PMID:22926577   PMID:24038504   PMID:24103481   PMID:25003183   PMID:25368380   PMID:25936639   PMID:26002313  
PMID:26563642   PMID:28251676   PMID:29476059   PMID:31885393   PMID:32357304  


Genomics

Comparative Map Data
Plp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X100,184,039 - 100,201,035 (+)NCBImRatBN7.2
mRatBN7.2 EnsemblX100,185,767 - 100,201,032 (+)Ensembl
Rnor_6.0X107,494,326 - 107,511,355 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX107,496,072 - 107,511,348 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X107,379,831 - 107,394,881 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X124,488,627 - 124,503,639 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X124,562,059 - 124,577,072 (+)NCBI
CeleraX101,020,110 - 101,035,276 (+)NCBICelera
Cytogenetic MapXq32NCBI
PLP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX103,773,718 - 103,792,619 (+)EnsemblGRCh38hg38GRCh38
GRCh38X103,776,506 - 103,792,619 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X103,031,434 - 103,047,548 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X102,918,410 - 102,934,204 (+)NCBINCBI36hg18NCBI36
Build 34X102,837,898 - 102,853,690NCBI
CeleraX103,470,449 - 103,486,558 (+)NCBI
Cytogenetic MapXq22.2NCBI
HuRefX92,687,547 - 92,703,609 (+)NCBIHuRef
CHM1_1X102,924,426 - 102,940,535 (+)NCBICHM1_1
Plp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X135,720,897 - 135,739,331 (+)NCBIGRCm39mm39
GRCm39 EnsemblX135,723,420 - 135,740,482 (+)Ensembl
GRCm38X136,820,148 - 136,838,582 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX136,822,671 - 136,839,733 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X133,357,375 - 133,372,282 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X132,169,200 - 132,184,107 (+)NCBImm8
CeleraX120,104,727 - 120,119,592 (+)NCBICelera
Cytogenetic MapXF1NCBI
cM MapX59.1NCBI
Plp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955548781,015 - 797,935 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955548781,522 - 797,246 (+)NCBIChiLan1.0ChiLan1.0
PLP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X103,353,181 - 103,412,513 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX103,353,184 - 103,412,513 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X93,015,098 - 93,031,193 (+)NCBIMhudiblu_PPA_v0panPan3
PLP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X77,191,112 - 77,207,772 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX77,191,150 - 77,205,964 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX63,420,093 - 63,434,914 (+)NCBI
ROS_Cfam_1.0X78,808,649 - 78,825,317 (+)NCBI
UMICH_Zoey_3.1X76,287,255 - 76,302,076 (+)NCBI
UNSW_CanFamBas_1.0X77,974,000 - 77,988,806 (+)NCBI
UU_Cfam_GSD_1.0X77,741,107 - 77,755,923 (+)NCBI
Plp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X77,107,149 - 77,123,012 (+)NCBI
SpeTri2.0NW_00493649910,534,953 - 10,553,411 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX84,665,925 - 84,695,533 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X84,676,627 - 84,683,517 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X98,648,731 - 98,655,621 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X91,671,535 - 91,687,693 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 EnsemblX91,671,878 - 91,687,878 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606516,533,357 - 16,552,347 (+)NCBIVero_WHO_p1.0
Plp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624954135,065 - 150,911 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
DXWox26  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X100,203,334 - 100,203,482 (+)MAPPERmRatBN7.2
Rnor_6.0X107,513,655 - 107,513,802NCBIRnor6.0
Rnor_5.0X107,397,181 - 107,397,328UniSTSRnor5.0
RGSC_v3.4X124,505,946 - 124,506,093UniSTSRGSC3.4
CeleraX101,037,576 - 101,037,723UniSTS
Cytogenetic MapXq35UniSTS
D4Ulb4  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXq35UniSTS
DXMit9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X100,200,819 - 100,200,920 (+)MAPPERmRatBN7.2
Rnor_6.0X107,511,140 - 107,511,240NCBIRnor6.0
Rnor_5.0X107,394,666 - 107,394,766UniSTSRnor5.0
RGSC_v3.4X124,503,431 - 124,503,531UniSTSRGSC3.4
CeleraX101,035,061 - 101,035,161UniSTS
Cytogenetic MapXq35UniSTS
PMC311008P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X100,194,197 - 100,195,139 (+)MAPPERmRatBN7.2
Rnor_6.0X107,504,519 - 107,505,460NCBIRnor6.0
Rnor_5.0X107,388,045 - 107,388,986UniSTSRnor5.0
RGSC_v3.4X124,496,811 - 124,497,752UniSTSRGSC3.4
CeleraX101,028,440 - 101,029,381UniSTS
Cytogenetic MapXq35UniSTS
D573  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X100,200,676 - 100,200,920 (+)MAPPERmRatBN7.2
Rnor_6.0X107,510,997 - 107,511,240NCBIRnor6.0
Rnor_5.0X107,394,523 - 107,394,766UniSTSRnor5.0
RGSC_v3.4X124,503,288 - 124,503,531UniSTSRGSC3.4
CeleraX101,034,918 - 101,035,161UniSTS
Cytogenetic MapXq35UniSTS
RH140080  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X100,200,230 - 100,200,435 (+)MAPPERmRatBN7.2
Rnor_6.0X107,510,551 - 107,510,755NCBIRnor6.0
Rnor_5.0X107,394,077 - 107,394,281UniSTSRnor5.0
RGSC_v3.4X124,502,843 - 124,503,047UniSTSRGSC3.4
CeleraX101,034,472 - 101,034,676UniSTS
RH 3.4 Map71131.62UniSTS
Cytogenetic MapXq35UniSTS
RH141820  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X100,199,170 - 100,199,372 (+)MAPPERmRatBN7.2
Rnor_6.0X107,509,491 - 107,509,692NCBIRnor6.0
Rnor_5.0X107,393,017 - 107,393,218UniSTSRnor5.0
RGSC_v3.4X124,501,783 - 124,501,984UniSTSRGSC3.4
CeleraX101,033,412 - 101,033,613UniSTS
RH 3.4 Map71128.32UniSTS
Cytogenetic MapXq35UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat
724551Glom1Glomerulus QTL 12.80.0004kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)X75294106120294106Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat


Related Rat Strains
The following Strains have been annotated to Plp1


Genetic Models
This gene Plp1 is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:485
Count of miRNA genes:263
Interacting mature miRNAs:327
Transcripts:ENSRNOT00000003283
Prediction methods:Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 25
Medium 8 2 2 29 35 3 2
Low 3 43 49 41 19 41 6 9 20 35 6 8 6
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_030990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC093596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB697155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ841934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M11185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M14126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M16471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M25888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X02809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X62523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X62524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X62525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X62526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X62527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X62611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000003283   ⟹   ENSRNOP00000003283
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX100,185,767 - 100,201,032 (+)Ensembl
Rnor_6.0 EnsemblX107,496,072 - 107,511,348 (+)Ensembl
RefSeq Acc Id: NM_030990   ⟹   NP_112252
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X100,185,767 - 100,201,035 (+)NCBI
Rnor_6.0X107,496,072 - 107,511,355 (+)NCBI
Rnor_5.0X107,379,831 - 107,394,881 (+)NCBI
RGSC_v3.4X124,488,627 - 124,503,639 (+)RGD
CeleraX101,020,110 - 101,035,276 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017601913   ⟹   XP_017457402
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X100,184,040 - 100,201,035 (+)NCBI
Rnor_6.0X107,494,332 - 107,511,355 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017601914   ⟹   XP_017457403
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X100,184,039 - 100,201,035 (+)NCBI
Rnor_6.0X107,494,326 - 107,511,355 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_112252   ⟸   NM_030990
- UniProtKB: P60203 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017457403   ⟸   XM_017601914
- Peptide Label: isoform X2
- UniProtKB: A0A097BVK2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457402   ⟸   XM_017601913
- Peptide Label: isoform X1
- UniProtKB: P60203 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000003283   ⟸   ENSRNOT00000003283

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701946
Promoter ID:EPDNEW_R12469
Type:initiation region
Name:Plp1_1
Description:proteolipid protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X107,496,063 - 107,496,123EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN-Lx/CubMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BUF/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
DA/OlaHsd (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
F344/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FXLE16/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/FarMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
HXB10/IpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEXF10A/StmMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
M520/NRrrcMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MWF/Hsd (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/OlalpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/RijCrl (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3354 AgrOrtholog
Ensembl Genes ENSRNOG00000002419 Ensembl, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000003283 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000003283 UniProtKB/Swiss-Prot
InterPro Myelin_PLP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myelin_PLP_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24943 UniProtKB/Swiss-Prot
NCBI Gene 24943 ENTREZGENE
PANTHER PTHR11683 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Myelin_PLP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Plp1 PhenoGen
PRINTS MYELINPLP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MYELIN_PLP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MYELIN_PLP_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PLP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A097BVK2 ENTREZGENE, UniProtKB/TrEMBL
  MYPR_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P04400 UniProtKB/Swiss-Prot
  P06905 UniProtKB/Swiss-Prot
  Q561K5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-09 Plp1  proteolipid protein 1  Plp1  proteolipid protein (myelin) 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Plp1  proteolipid protein (myelin) 1  Plp  proteolipid protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Plp  proteolipid protein      Symbol and Name updated 629477 APPROVED
2003-03-06 Plp  proteolipid protein  Plp1    Data Merged 628472 PROVISIONAL
2002-08-07 Plp1        Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Plp  Proteolipid protein (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression altered expression (over or under) by oligodendrocytes causes axonal pathology and is directly responsible for neuron viability 1298599
gene_expression expressed during development under strict regulation 729337
gene_function major integral myelin membrane protein 729337