Kif14 (kinesin family member 14) - Rat Genome Database

Name: Kif14
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Kif14 (kinesin family member 14) Rattus norvegicus

Analyze

Symbol:

Kif14

Name:

kinesin family member 14

RGD ID:

1310650

Description:

Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and PDZ domain binding activity. Predicted to be involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; brain development; and regulation of cell cycle process. Predicted to act upstream of or within several processes, including negative regulation of integrin activation; regulation of Rap protein signal transduction; and substrate adhesion-dependent cell spreading. Predicted to be located in Flemming body; cytosol; and spindle midzone. Predicted to be part of kinesin complex. Predicted to be active in microtubule. Predicted to colocalize with plasma membrane. Human ortholog(s) of this gene implicated in Meckel syndrome and primary autosomal recessive microcephaly. Orthologous to human KIF14 (kinesin family member 14); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide.

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

kinesin-like protein KIF14; LOC360849

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	KIF14 (kinesin family member 14)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Kif14 (kinesin family member 14)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Kif14 (kinesin family member 14)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	KIF14 (kinesin family member 14)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	KIF14 (kinesin family member 14)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Kif14 (kinesin family member 14)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	KIF14 (kinesin family member 14)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	KIF14 (kinesin family member 14)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Kif14 (kinesin family member 14)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	CRYBB2 (crystallin beta B2)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	KIF14 (kinesin family member 14)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Kif14 (kinesin family member 14)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	kif14 (kinesin family member 14)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	neb	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	kif14	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	13	47,926,975 - 47,990,598 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	47,927,044 - 47,989,164 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	13	53,350,073 - 53,421,992 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	53,351,717 - 53,420,111 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	58,400,186 - 58,466,702 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	49,514,095 - 49,576,012 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	49,509,198 - 49,592,154 (+)	NCBI
Celera	13	48,238,110 - 48,300,358 (+)	NCBI		Celera
Cytogenetic Map	13	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

COVID-19 (ISO)

familial adult myoclonic epilepsy 5 (ISO)

gastrointestinal stromal tumor (ISO)

genetic disease (ISO)

hepatocellular carcinoma (ISO)

Hypokalemic Periodic Paralysis, Type 1 (ISO)

Joubert syndrome (ISO)

Meckel Syndrome 12 (ISO)

parathyroid carcinoma (ISO)

Primary Autosomal Recessive Microcephaly 20 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

(1->4)-beta-D-glucan (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

5-fluorouracil (ISO)

acrylamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

antimycin A (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

azoxystrobin (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (ISO)

butanal (ISO)

cadmium atom (ISO)

calcitriol (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

coumestrol (ISO)

cyclosporin A (ISO)

disodium selenite (ISO)

doxorubicin (ISO)

Enterolactone (ISO)

folic acid (ISO)

formaldehyde (ISO)

fulvestrant (ISO)

genistein (ISO)

indole-3-methanol (EXP)

irinotecan (ISO)

ivermectin (ISO)

leflunomide (ISO)

lidocaine (EXP)

lipopolysaccharide (ISO)

lucanthone (ISO)

methotrexate (ISO)

methyl methanesulfonate (ISO)

N-methyl-4-phenylpyridinium (ISO)

N-Nitrosopyrrolidine (ISO)

nickel atom (ISO)

ozone (ISO)

palbociclib (ISO)

paracetamol (ISO)

paraquat (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

pirinixic acid (ISO)

piroxicam (ISO)

potassium chromate (ISO)

progesterone (ISO)

propanal (ISO)

quercetin (ISO)

resveratrol (ISO)

rotenone (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sulforaphane (ISO)

sulindac (ISO)

sunitinib (ISO)

testosterone (ISO)

trichloroethene (EXP)

triclosan (ISO)

trimellitic anhydride (ISO)

triptonide (ISO)

troglitazone (ISO)

trovafloxacin (ISO)

tungsten (ISO)

tunicamycin (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

activation of protein kinase activity (ISO)

cell division (ISO)

cell proliferation in forebrain (ISO)

cerebellar cortex development (ISO)

cerebellar granular layer structural organization (ISO)

cerebellar Purkinje cell layer structural organization (ISO)

cerebral cortex development (ISO)

establishment of protein localization (ISO)

hippocampus development (ISO)

microtubule depolymerization (ISO)

microtubule-based movement (IBA)

mitotic metaphase plate congression (ISO)

negative regulation of apoptotic process (ISO)

negative regulation of integrin activation (ISO)

negative regulation of neuron apoptotic process (ISO)

olfactory bulb development (ISO)

positive regulation of cell population proliferation (ISO)

positive regulation of cytokinesis (ISO)

proteasome-mediated ubiquitin-dependent protein catabolic process (ISO)

regulation of cell adhesion (ISO)

regulation of cell growth (ISO)

regulation of cell maturation (ISO)

regulation of cell migration (ISO)

regulation of G1/S transition of mitotic cell cycle (ISO)

regulation of G2/M transition of mitotic cell cycle (ISO)

regulation of myelination (ISO)

regulation of neuron apoptotic process (ISO)

regulation of Rap protein signal transduction (ISO)

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (ISO)

substrate adhesion-dependent cell spreading (ISO)

Cellular Component

cytosol (IEA,ISO)

Flemming body (IEA,ISO)

kinesin complex (IBA)

microtubule (IBA,ISO)

midbody (ISO)

plasma membrane (ISO)

spindle midzone (ISO)

Molecular Function

ATP binding (ISO)

ATP hydrolysis activity (IBA,ISO)

microtubule binding (IBA,ISO)

microtubule motor activity (IBA)

PDZ domain binding (ISO)

plus-end-directed microtubule motor activity (ISO)

protein binding (ISO)

protein kinase binding (ISO)

tubulin binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:15843429	PMID:16431929	PMID:19946888	PMID:20309963	PMID:23209302	PMID:23308235	PMID:24784001	PMID:24854087	PMID:24931760	PMID:24949858

Genomics

Comparative Map Data

Kif14
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	13	47,926,975 - 47,990,598 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	47,927,044 - 47,989,164 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	13	53,350,073 - 53,421,992 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	53,351,717 - 53,420,111 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	58,400,186 - 58,466,702 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	49,514,095 - 49,576,012 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	49,509,198 - 49,592,154 (+)	NCBI
Celera	13	48,238,110 - 48,300,358 (+)	NCBI		Celera
Cytogenetic Map	13	q13	NCBI

KIF14
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	200,551,497 - 200,620,751 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	1	200,551,497 - 200,620,751 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	200,520,625 - 200,589,879 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	198,787,930 - 198,856,485 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	197,252,963 - 197,321,519	NCBI
Celera	1	173,643,207 - 173,712,428 (-)	NCBI		Celera
Cytogenetic Map	1	q32.1	NCBI
HuRef	1	171,687,033 - 171,756,258 (-)	NCBI		HuRef
CHM1_1	1	201,943,245 - 202,012,495 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	199,808,434 - 199,877,845 (-)	NCBI		T2T-CHM13v2.0

Kif14
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	136,394,044 - 136,483,676 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	136,394,081 - 136,459,249 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	136,466,301 - 136,555,938 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	136,466,343 - 136,531,511 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	138,364,535 - 138,428,088 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	138,284,369 - 138,347,922 (+)	NCBI		MGSCv36	mm8
Celera	1	139,105,105 - 139,173,763 (+)	NCBI		Celera
Cytogenetic Map	1	E4	NCBI
cM Map	1	59.8	NCBI

Kif14
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955406	36,737,484 - 36,791,756 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955406	36,732,135 - 36,791,756 (-)	NCBI	ChiLan1.0	ChiLan1.0

KIF14
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	1	48,720,667 - 48,788,642 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	176,156,870 - 176,223,093 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	180,462,381 - 180,528,302 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	180,462,578 - 180,526,323 (-)	Ensembl	panpan1.1		panPan2

KIF14
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	2,548,407 - 2,602,371 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	2,548,258 - 2,601,581 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	2,221,247 - 2,287,287 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	2,195,400 - 2,250,507 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	2,195,260 - 2,249,717 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	2,167,231 - 2,233,487 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	2,268,791 - 2,334,912 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	2,299,753 - 2,366,285 (+)	NCBI		UU_Cfam_GSD_1.0

Kif14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	74,468,314 - 74,529,610 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936567	3,704,672 - 3,764,111 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

KIF14
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	23,123,480 - 23,174,273 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	10	23,123,379 - 23,177,919 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	27,601,816 - 27,655,240 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

KIF14
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	28,789,952 - 28,856,713 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	28,789,614 - 28,856,570 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666055	29,591,469 - 29,660,607 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Kif14
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624807	10,092,934 - 10,143,399 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624807	10,093,518 - 10,144,484 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Kif14
365 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	31
Count of miRNA genes:	30
Interacting mature miRNAs:	31
Transcripts:	ENSRNOT00000012038
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	1	101056920	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	1	101056920	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	101056920	Rat
1581554	Pur11	Proteinuria QTL 11			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	5994833	77046787	Rat
1581573	Uae36	Urinary albumin excretion QTL 36			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	5994833	77046787	Rat
1581570	Eae17	Experimental allergic encephalomyelitis QTL 17	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	13	8897350	101631289	Rat
7411662	Foco29	Food consumption QTL 29	20.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	13	9313465	54313465	Rat
9589141	Insul28	Insulin level QTL 28	10.82	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	13	9313465	54313465	Rat
2317040	Aia21	Adjuvant induced arthritis QTL 21	2.75		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	9831541	54831541	Rat
2317046	Aia8	Adjuvant induced arthritis QTL 8	3.9700000286102295		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	9831541	54831541	Rat
631645	Bp121	Blood pressure QTL 121	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	14915655	59915655	Rat
9589164	Gluco66	Glucose level QTL 66	6.67	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	13	15158722	60158722	Rat
1331784	Bp222	Blood pressure QTL 222	2.944		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	17694436	53050594	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	20605871	101339738	Rat
61391	Bp5	Blood pressure QTL 5	5.6		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	22301875	67301875	Rat
70170	Eae14	Experimental allergic encephalomyelitis QTL 14		0.0024	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	13	23203448	68203448	Rat
6893338	Cm76	Cardiac mass QTL 76	0	0.99	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	13	23692969	68692969	Rat
1558644	Cm45	Cardiac mass QTL 45	3.6	0.002	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	13	23692969	68692969	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	30395351	101056920	Rat
2301962	Cm72	Cardiac mass QTL 72	4.12		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	13	31241331	58363171	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	31241331	93395974	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	31241331	93395974	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	31241331	93395974	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	13	31241331	93395974	Rat
2303563	Bw89	Body weight QTL 89	6		body mass (VT:0001259)	body weight (CMO:0000012)	13	32284471	77284471	Rat
61340	Bp25	Blood pressure QTL 25	4.2	0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	34535218	79535218	Rat
12879477	Bp401	Blood pressure QTL 401			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	37262092	82262092	Rat
61349	Bp31	Blood pressure QTL 31	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	37374509	82374509	Rat
70220	Bp55	Blood pressure QTL 55	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	37374509	82374509	Rat
4889861	Pur29	Proteinuria QTL 29	13.8	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	37415584	80753406	Rat
1331750	Bp220	Blood pressure QTL 220	2.98		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	37415584	82415584	Rat
1549897	Stresp12	Stress response QTL 12	3.35		stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	13	38433408	83433408	Rat
619615	Bp80	Blood pressure QTL 80		0.0354	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	39754544	84754544	Rat
6893344	Cm79	Cardiac mass QTL 79	1.5	0.04	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	13	43720770	62022792	Rat
12879444	Bp397	Blood pressure QTL 397			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	45049404	90049404	Rat
12879471	Bp398	Blood pressure QTL 398			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	45514719	90514719	Rat
12879441	Bp396	Blood pressure QTL 396			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	45699983	90699983	Rat
1298066	Bp159	Blood pressure QTL 159		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	46088046	91088046	Rat
71119	Thym2	Thymus enlargement QTL 2	3.8		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	13	46197976	84753113	Rat

Markers in Region

AU049182

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	47,956,867 - 47,957,164 (+)	MAPPER	mRatBN7.2
mRatBN7.2	16	79,362,320 - 79,363,905 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	85,175,580 - 85,177,164	NCBI	Rnor6.0
Rnor_6.0	13	53,381,304 - 53,381,598	NCBI	Rnor6.0
Rnor_5.0	16	84,615,001 - 84,616,585	UniSTS	Rnor5.0
Rnor_5.0	13	58,430,632 - 58,430,926	UniSTS	Rnor5.0
RGSC_v3.4	13	49,542,734 - 49,543,028	UniSTS	RGSC3.4
RGSC_v3.4	16	84,722,568 - 84,724,154	UniSTS	RGSC3.4
Celera	16	77,149,496 - 77,151,080	UniSTS
Celera	13	48,267,324 - 48,267,584	UniSTS
Cytogenetic Map	13	q13	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		6	18	12	9	12			16	12	13
Low	3	27	25	19	10	19	2	2	40	10	28	9	2
Below cutoff		7	10	6		6	6	7	14	10		2	6

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008762819	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017599026	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039091329	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039091330	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473958	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000242	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000012038 ⟹ ENSRNOP00000012038

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	47,927,044 - 47,989,164 (+)	Ensembl
Rnor_6.0 Ensembl	13	53,351,717 - 53,420,111 (+)	Ensembl

RefSeq Acc Id:

XM_039091329 ⟹ XP_038947257

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	47,926,975 - 47,990,598 (+)	NCBI

RefSeq Acc Id:

XM_039091330 ⟹ XP_038947258

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	47,926,975 - 47,990,598 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_038947257	(Get FASTA)	NCBI Sequence Viewer
	XP_038947258	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM09658	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

ENSRNOP00000012038 ⟸ ENSRNOT00000012038

RefSeq Acc Id:	XP_038947258 ⟸ XM_039091330
- UniProtKB:	D3ZE01 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038947257 ⟸ XM_039091329
- UniProtKB:	D3ZE01 (UniProtKB/TrEMBL)

Protein Domains

FHA Kinesin motor

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZE01-F1-model_v2	AlphaFold	D3ZE01	1-1672	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310650	AgrOrtholog
BioCyc Gene	G2FUF-18170	BioCyc
Ensembl Genes	ENSRNOG00000037211	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000012038	ENTREZGENE
	ENSRNOP00000012038.8	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000012038	ENTREZGENE
	ENSRNOT00000012038.8	UniProtKB/TrEMBL
Gene3D-CATH	2.60.200.20	UniProtKB/TrEMBL
	3.40.850.10	UniProtKB/TrEMBL
InterPro	FHA_dom	UniProtKB/TrEMBL
	Kinesin_assoc	UniProtKB/TrEMBL
	Kinesin_motor_CS	UniProtKB/TrEMBL
	Kinesin_motor_dom	UniProtKB/TrEMBL
	Kinesin_motor_dom_sf	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
	SMAD_FHA_domain	UniProtKB/TrEMBL
NCBI Gene	360849	ENTREZGENE
PANTHER	AFADIN	UniProtKB/TrEMBL
	SI:CH73-375G18.1	UniProtKB/TrEMBL
Pfam	FHA	UniProtKB/TrEMBL
	Kinesin	UniProtKB/TrEMBL
	Kinesin_assoc	UniProtKB/TrEMBL
PhenoGen	Kif14	PhenoGen
PRINTS	KINESINHEAVY	UniProtKB/TrEMBL
PROSITE	FHA_DOMAIN	UniProtKB/TrEMBL
	KINESIN_MOTOR_DOMAIN1	UniProtKB/TrEMBL
	KINESIN_MOTOR_DOMAIN2	UniProtKB/TrEMBL
SMART	FHA	UniProtKB/TrEMBL
	KISc	UniProtKB/TrEMBL
Superfamily-SCOP	SMAD_FHA	UniProtKB/TrEMBL
	SSF52540	UniProtKB/TrEMBL
UniProt	D3ZE01	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Kif14	kinesin family member 14	Kif14_predicted	kinesin family member 14 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Kif14_predicted	kinesin family member 14 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

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