Tifab (TIFA inhibitor) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Tifab (TIFA inhibitor) Rattus norvegicus
Analyze
Symbol: Tifab
Name: TIFA inhibitor
RGD ID: 1311681
Description: Predicted to enable deubiquitinase activator activity. Predicted to be involved in several processes, including cochlea morphogenesis; cranial nerve development; and hard palate morphogenesis. Predicted to act upstream of with a negative effect on toll-like receptor signaling pathway. Predicted to act upstream of or within several processes, including hemopoiesis; lipopolysaccharide-mediated signaling pathway; and regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator. Orthologous to human TIFAB (TIFA inhibitor); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC364674; MGC108845; RGD1311681; similar to MGC37193 protein; TIFA inhibitor B; TIFA-like protein; TRAF-interacting protein with FHA domain-containing protein B; TRAF-interacting protein with forkhead-associated domain, family member B
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2178,433,406 - 8,436,541 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl178,431,635 - 8,436,592 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx178,449,150 - 8,452,171 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0179,982,163 - 9,985,180 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0178,445,541 - 8,448,562 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0179,234,948 - 9,239,266 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl179,236,249 - 9,239,265 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01711,393,749 - 11,400,318 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41714,409,442 - 14,412,459 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11714,409,441 - 14,412,458 (+)NCBI
Celera178,517,840 - 8,520,857 (+)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:23419067  


Genomics

Comparative Map Data
Tifab
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2178,433,406 - 8,436,541 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl178,431,635 - 8,436,592 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx178,449,150 - 8,452,171 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0179,982,163 - 9,985,180 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0178,445,541 - 8,448,562 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0179,234,948 - 9,239,266 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl179,236,249 - 9,239,265 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01711,393,749 - 11,400,318 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41714,409,442 - 14,412,459 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11714,409,441 - 14,412,458 (+)NCBI
Celera178,517,840 - 8,520,857 (+)NCBICelera
Cytogenetic Map17p14NCBI
TIFAB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385135,444,226 - 135,452,351 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5135,444,226 - 135,452,351 (-)EnsemblGRCh38hg38GRCh38
GRCh375134,779,916 - 134,788,041 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365134,812,457 - 134,815,988 (-)NCBINCBI36Build 36hg18NCBI36
Celera5130,908,347 - 130,911,878 (-)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5129,972,262 - 129,975,793 (-)NCBIHuRef
CHM1_15134,217,201 - 134,220,732 (-)NCBICHM1_1
T2T-CHM13v2.05135,971,397 - 135,979,522 (-)NCBIT2T-CHM13v2.0
Tifab
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391356,318,917 - 56,326,816 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1356,321,517 - 56,326,698 (-)EnsemblGRCm39 Ensembl
GRCm381356,173,703 - 56,179,002 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1356,173,704 - 56,178,885 (-)EnsemblGRCm38mm10GRCm38
MGSCv371356,275,064 - 56,280,246 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361356,183,333 - 56,188,423 (-)NCBIMGSCv36mm8
Celera1357,228,509 - 57,233,670 (-)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1330.06NCBI
TIFAB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan15128,871,681 - 128,880,987 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05130,836,697 - 130,846,050 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15136,982,454 - 136,985,986 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5136,983,040 - 136,983,525 (-)Ensemblpanpan1.1panPan2
TIFAB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11123,492,317 - 23,495,825 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1123,492,867 - 23,493,352 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1122,241,429 - 22,244,942 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01124,309,269 - 24,312,784 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1124,309,819 - 24,310,304 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11122,997,445 - 23,000,957 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01122,863,108 - 22,866,620 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01123,513,134 - 23,516,647 (-)NCBIUU_Cfam_GSD_1.0
Tifab
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213123,595,278 - 123,596,398 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365972,620,661 - 2,621,302 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TIFAB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2137,672,407 - 137,678,612 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12137,675,245 - 137,678,880 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TIFAB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12338,228,904 - 38,232,892 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603439,683,902 - 39,686,777 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tifab
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473311,578,934 - 11,587,250 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tifab
28 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:317
Count of miRNA genes:182
Interacting mature miRNAs:215
Transcripts:ENSRNOT00000015878
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122871563Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17211514921881669Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
631499Stl1Serum triglyceride level QTL 13.6blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)17327139827389946Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)17429913021293263Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17429913021293263Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17435448727028127Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17435448727028127Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
1581553Pur14Proteinuria QTL 145.30.0001urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)17797996816317111Rat

Markers in Region
RPLP1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2178,431,994 - 8,432,082 (+)MAPPERmRatBN7.2
mRatBN7.2862,395,183 - 62,395,271 (+)MAPPERmRatBN7.2
Rnor_6.0866,863,319 - 66,863,406NCBIRnor6.0
Rnor_6.0179,234,720 - 9,234,807NCBIRnor6.0
Rnor_5.01711,393,529 - 11,393,616UniSTSRnor5.0
Rnor_5.0866,595,700 - 66,595,787UniSTSRnor5.0
RGSC_v3.4866,047,396 - 66,047,483UniSTSRGSC3.4
RGSC_v3.41714,407,913 - 14,408,000UniSTSRGSC3.4
Celera178,516,311 - 8,516,398UniSTS
Celera861,814,968 - 61,815,055UniSTS
Cytogenetic Map17p14UniSTS
Cytogenetic Map8q24UniSTS
RH131325  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2178,436,193 - 8,436,380 (+)MAPPERmRatBN7.2
Rnor_6.0179,238,919 - 9,239,105NCBIRnor6.0
Rnor_5.01711,397,728 - 11,397,914UniSTSRnor5.0
RGSC_v3.41714,412,112 - 14,412,298UniSTSRGSC3.4
Celera178,520,510 - 8,520,696UniSTS
RH 3.4 Map1774.4UniSTS
Cytogenetic Map17p14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 11 2 1
Low 2 35 57 41 8 41 8 9 72 35 36 10 8
Below cutoff 6 2 2 3

Sequence


RefSeq Acc Id: ENSRNOT00000015878   ⟹   ENSRNOP00000015878
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl178,431,635 - 8,436,592 (+)Ensembl
Rnor_6.0 Ensembl179,236,249 - 9,239,265 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000116729   ⟹   ENSRNOP00000083675
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl178,433,406 - 8,436,544 (+)Ensembl
RefSeq Acc Id: NM_001025029   ⟹   NP_001020200
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2178,433,524 - 8,436,541 (+)NCBI
Rnor_6.0179,236,249 - 9,239,266 (+)NCBI
Rnor_5.01711,393,749 - 11,400,318 (+)NCBI
RGSC_v3.41714,409,442 - 14,412,459 (+)RGD
Celera178,517,840 - 8,520,857 (+)RGD
Sequence:
RefSeq Acc Id: XM_006253578   ⟹   XP_006253640
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2178,433,406 - 8,436,541 (+)NCBI
Rnor_6.0179,234,948 - 9,239,266 (+)NCBI
Rnor_5.01711,393,749 - 11,400,318 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006253579   ⟹   XP_006253641
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2178,433,406 - 8,436,541 (+)NCBI
Rnor_6.0179,234,948 - 9,239,266 (+)NCBI
Rnor_5.01711,393,749 - 11,400,318 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001020200   ⟸   NM_001025029
- UniProtKB: Q5BK67 (UniProtKB/Swiss-Prot),   A6KAN8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253640   ⟸   XM_006253578
- Peptide Label: isoform X1
- UniProtKB: Q5BK67 (UniProtKB/Swiss-Prot),   A6KAN8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253641   ⟸   XM_006253579
- Peptide Label: isoform X1
- UniProtKB: Q5BK67 (UniProtKB/Swiss-Prot),   A6KAN8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000015878   ⟸   ENSRNOT00000015878
RefSeq Acc Id: ENSRNOP00000083675   ⟸   ENSRNOT00000116729
Protein Domains
FHA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5BK67-F1-model_v2 AlphaFold Q5BK67 1-147 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700294
Promoter ID:EPDNEW_R10817
Type:multiple initiation site
Name:Tifab_1
Description:TIFA inhibitor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0179,236,156 - 9,236,216EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311681 AgrOrtholog
BioCyc Gene G2FUF-10245 BioCyc
Ensembl Genes ENSRNOG00000011947 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015878 ENTREZGENE
  ENSRNOT00000015878.5 UniProtKB/Swiss-Prot
  ENSRNOT00000116729 ENTREZGENE
  ENSRNOT00000116729.1 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.200.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7367314 IMAGE-MGC_LOAD
InterPro FHA_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD_FHA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIFA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:364674 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:108845 IMAGE-MGC_LOAD
NCBI Gene 364674 ENTREZGENE
PANTHER PTHR31266 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRAF-INTERACTING PROTEIN WITH FHA DOMAIN-CONTAINING PROTEIN B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tifab PhenoGen
RatGTEx ENSRNOG00000011947 RatGTEx
Superfamily-SCOP SMAD/FHA domain UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6KAN8 ENTREZGENE, UniProtKB/TrEMBL
  Q5BK67 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-08 Tifab  TIFA inhibitor  Tifab  TIFA inhibitor B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-03 Tifab  TIFA inhibitor B  Tifab  TRAF-interacting protein with forkhead-associated domain, family member B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-31 Tifab  TRAF-interacting protein with forkhead-associated domain, family member B  RGD1311681  similar to MGC37193 protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1311681  similar to MGC37193 protein  RGD1311681_predicted  similar to MGC37193 protein (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1311681_predicted  similar to MGC37193 protein (predicted)  LOC364674_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC364674_predicted  similar to MGC37193 protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL