TIFAB (TIFA inhibitor) - Rat Genome Database

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Gene: TIFAB (TIFA inhibitor) Homo sapiens
Analyze
Symbol: TIFAB
Name: TIFA inhibitor
RGD ID: 2291818
HGNC Page HGNC
Description: Involved in several processes, including animal organ morphogenesis; cranial nerve development; and hard palate morphogenesis.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: FLJ00292; TIFA-like protein; TIFA-related protein TIFAB; TRAF-interacting protein with FHA domain-containing protein B; TRAF-interacting protein with forkhead-associated domain, family member B
RGD Orthologs
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl5135,444,226 - 135,452,351 (-)EnsemblGRCh38hg38GRCh38
GRCh385135,444,226 - 135,452,351 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375134,779,916 - 134,788,041 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365134,812,457 - 134,815,988 (-)NCBINCBI36hg18NCBI36
Celera5130,908,347 - 130,911,878 (-)NCBI
Cytogenetic Map5q31.1NCBI
HuRef5129,972,262 - 129,975,793 (-)NCBIHuRef
CHM1_15134,217,201 - 134,220,732 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11181995   PMID:14702039   PMID:15047173   PMID:23419067   PMID:26458771   PMID:32101751   PMID:32910997  


Genomics

Comparative Map Data
TIFAB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl5135,444,226 - 135,452,351 (-)EnsemblGRCh38hg38GRCh38
GRCh385135,444,226 - 135,452,351 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375134,779,916 - 134,788,041 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365134,812,457 - 134,815,988 (-)NCBINCBI36hg18NCBI36
Celera5130,908,347 - 130,911,878 (-)NCBI
Cytogenetic Map5q31.1NCBI
HuRef5129,972,262 - 129,975,793 (-)NCBIHuRef
CHM1_15134,217,201 - 134,220,732 (-)NCBICHM1_1
Tifab
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391356,318,917 - 56,326,816 (-)NCBIGRCm39mm39
GRCm39 Ensembl1356,321,517 - 56,326,698 (-)Ensembl
GRCm381356,173,703 - 56,179,002 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1356,173,704 - 56,178,885 (-)EnsemblGRCm38mm10GRCm38
MGSCv371356,275,064 - 56,280,246 (-)NCBIGRCm37mm9NCBIm37
MGSCv361356,183,333 - 56,188,423 (-)NCBImm8
Celera1357,228,509 - 57,233,670 (-)NCBICelera
Cytogenetic Map13B1NCBI
Tifab
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2178,433,406 - 8,436,541 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl178,431,635 - 8,436,592 (+)Ensembl
Rnor_6.0179,234,948 - 9,239,266 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl179,236,249 - 9,239,265 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01711,393,749 - 11,400,318 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41714,409,442 - 14,412,459 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11714,409,441 - 14,412,458 (+)NCBI
Celera178,517,840 - 8,520,857 (+)NCBICelera
Cytogenetic Map17p14NCBI
TIFAB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15136,982,454 - 136,985,986 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5136,983,040 - 136,983,525 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05130,836,697 - 130,846,050 (-)NCBIMhudiblu_PPA_v0panPan3
TIFAB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11123,492,317 - 23,495,825 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1123,492,867 - 23,493,352 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1122,241,429 - 22,244,942 (-)NCBI
ROS_Cfam_1.01124,309,269 - 24,312,784 (-)NCBI
ROS_Cfam_1.0 Ensembl1124,309,819 - 24,310,304 (-)Ensembl
UMICH_Zoey_3.11122,997,445 - 23,000,957 (-)NCBI
UNSW_CanFamBas_1.01122,863,108 - 22,866,620 (-)NCBI
UU_Cfam_GSD_1.01123,513,134 - 23,516,647 (-)NCBI
Tifab
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213123,595,278 - 123,596,398 (-)NCBI
SpeTri2.0NW_0049365972,620,661 - 2,621,302 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TIFAB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2137,672,407 - 137,678,612 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12137,675,245 - 137,678,880 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TIFAB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12338,228,904 - 38,232,892 (-)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603439,683,902 - 39,686,777 (+)NCBIVero_WHO_p1.0
Tifab
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473311,578,934 - 11,587,250 (+)NCBIHetGla_female_1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2600
Count of miRNA genes:1167
Interacting mature miRNAs:1434
Transcripts:ENST00000537858
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 32
Low 245 59 64 24 385 22 280 4 27 20 368 160 4 58 114
Below cutoff 1426 1733 1026 409 904 282 2668 1247 2343 193 611 896 127 812 1733 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000537858   ⟹   ENSP00000440509
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl5135,444,226 - 135,452,351 (-)Ensembl
RefSeq Acc Id: NM_001099221   ⟹   NP_001092691
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385135,444,226 - 135,452,351 (-)NCBI
GRCh375134,784,558 - 134,788,089 (-)RGD
Build 365134,812,457 - 134,815,988 (-)NCBI Archive
Celera5130,908,347 - 130,911,878 (-)RGD
HuRef5129,972,262 - 129,975,793 (-)ENTREZGENE
CHM1_15134,217,201 - 134,220,732 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001092691 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAD89018 (Get FASTA)   NCBI Sequence Viewer  
  EAW62215 (Get FASTA)   NCBI Sequence Viewer  
  Q6ZNK6 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001092691   ⟸   NM_001099221
- UniProtKB: Q6ZNK6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000440509   ⟸   ENST00000537858
Protein Domains
FHA

Promoters
RGD ID:6870646
Promoter ID:EPDNEW_H8488
Type:initiation region
Name:TIFAB_1
Description:TIFA inhibitor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H8489  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh385135,452,334 - 135,452,394EPDNEW
RGD ID:6870648
Promoter ID:EPDNEW_H8489
Type:initiation region
Name:TIFAB_2
Description:TIFA inhibitor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H8488  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh385135,452,452 - 135,452,512EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 5q23.3-33.2(chr5:130860928-155321811)x3 copy number gain See cases [RCV000051193] Chr5:130860928..155321811 [GRCh38]
Chr5:130196621..154701371 [GRCh37]
Chr5:130224520..154681564 [NCBI36]
Chr5:5q23.3-33.2
pathogenic
GRCh38/hg38 5q31.1-31.2(chr5:133401565-138437038)x1 copy number loss See cases [RCV000052114] Chr5:133401565..138437038 [GRCh38]
Chr5:132737257..137772727 [GRCh37]
Chr5:132765156..137800626 [NCBI36]
Chr5:5q31.1-31.2
pathogenic
GRCh38/hg38 5q21.3-33.2(chr5:106619588-156124387)x1 copy number loss See cases [RCV000053524] Chr5:106619588..156124387 [GRCh38]
Chr5:105955289..155551397 [GRCh37]
Chr5:105983188..155483975 [NCBI36]
Chr5:5q21.3-33.2
pathogenic
GRCh38/hg38 5q31.1-31.3(chr5:135297294-140106003)x3 copy number gain See cases [RCV000133750] Chr5:135297294..140106003 [GRCh38]
Chr5:134632984..139485588 [GRCh37]
Chr5:134660883..139465772 [NCBI36]
Chr5:5q31.1-31.3
pathogenic
GRCh38/hg38 5q31.1(chr5:131626503-135815054)x1 copy number loss See cases [RCV000135442] Chr5:131626503..135815054 [GRCh38]
Chr5:130962196..135150743 [GRCh37]
Chr5:130990095..135178642 [NCBI36]
Chr5:5q31.1
pathogenic
GRCh38/hg38 5q23.3-33.2(chr5:129847794-153353546)x3 copy number gain See cases [RCV000138808] Chr5:129847794..153353546 [GRCh38]
Chr5:129183487..152733106 [GRCh37]
Chr5:129211386..152713299 [NCBI36]
Chr5:5q23.3-33.2
pathogenic
GRCh37/hg19 5q15-35.3(chr5:94844077-178830410)x3 copy number gain not provided [RCV000487658] Chr5:94844077..178830410 [GRCh37]
Chr5:5q15-35.3
likely benign
NC_000005.9:g.(?_86400000)_(154000000_?)del deletion Familial adenomatous polyposis 1 [RCV001381154]|Hereditary cancer-predisposing syndrome [RCV000554476] Chr5:86400000..154000000 [GRCh37]
Chr5:5q14.3-33.2
pathogenic
GRCh37/hg19 5q23.3-33.3(chr5:130125085-157574910)x3 copy number gain See cases [RCV000449349] Chr5:130125085..157574910 [GRCh37]
Chr5:5q23.3-33.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789) copy number gain See cases [RCV000510723] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5q21.3-35.3(chr5:106716357-180687338)x3 copy number gain See cases [RCV000448245] Chr5:106716357..180687338 [GRCh37]
Chr5:5q21.3-35.3
pathogenic
GRCh37/hg19 5p15.1-q35.2(chr5:17628741-176575720)x1 copy number loss See cases [RCV000511978] Chr5:17628741..176575720 [GRCh37]
Chr5:5p15.1-q35.2
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789)x3 copy number gain See cases [RCV000512039] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:13648-180905029)x3 copy number gain not provided [RCV000744317] Chr5:13648..180905029 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:25328-180693344)x3 copy number gain not provided [RCV000744323] Chr5:25328..180693344 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5q23.2-31.2(chr5:126377719-136270989)x1 copy number loss not provided [RCV000762739] Chr5:126377719..136270989 [GRCh37]
Chr5:5q23.2-31.2
likely pathogenic
Single allele deletion Neurodevelopmental disorder [RCV000787436] Chr5:14685137..149511942 [GRCh37]
Chr5:5p15.2-q32
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:34024 AgrOrtholog
COSMIC TIFAB COSMIC
Ensembl Genes ENSG00000255833 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000440509 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000537858 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000255833 GTEx
HGNC ID HGNC:34024 ENTREZGENE
Human Proteome Map TIFAB Human Proteome Map
InterPro FHA_dom UniProtKB/Swiss-Prot
  SMAD_FHA_dom_sf UniProtKB/Swiss-Prot
  TIFA UniProtKB/Swiss-Prot
KEGG Report hsa:497189 UniProtKB/Swiss-Prot
NCBI Gene 497189 ENTREZGENE
OMIM 612663 OMIM
PANTHER PTHR31266 UniProtKB/Swiss-Prot
Pfam FHA UniProtKB/Swiss-Prot
PharmGKB PA162405786 PharmGKB
Superfamily-SCOP SSF49879 UniProtKB/Swiss-Prot
UniProt Q6ZNK6 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q5H8A9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-02 TIFAB  TIFA inhibitor    TRAF-interacting protein with forkhead-associated domain, family member B  Symbol and/or name change 5135510 APPROVED
2011-09-01 TIFAB  TRAF-interacting protein with forkhead-associated domain, family member B  TIFAB  TRAF-interacting protein with forkhead-associated domain, family member B  Symbol and/or name change 5135510 APPROVED