Arhgap45 (Rho GTPase activating protein 45) - Rat Genome Database
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Gene: Arhgap45 (Rho GTPase activating protein 45) Rattus norvegicus
Analyze
Symbol: Arhgap45
Name: Rho GTPase activating protein 45
RGD ID: 1308662
Description: Predicted to be involved in intracellular signal transduction. Orthologous to human ARHGAP45 (Rho GTPase activating protein 45); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: histocompatibility (minor) HA-1; Hmha1; LOC314618; minor histocompatibility protein HA-1; RGD1308662; rho GTPase-activating protein 45; similar to PTPL1-associated RhoGAP 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.279,674,873 - 9,690,286 (-)NCBI
Rnor_6.0 Ensembl712,541,061 - 12,741,296 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0712,541,032 - 12,741,314 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0712,711,159 - 12,910,971 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,187,348 - 11,202,717 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1711,187,782 - 11,203,831 (-)NCBI
Celera77,850,690 - 7,865,940 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

Additional References at PubMed
PMID:19946888  


Genomics

Comparative Map Data
Arhgap45
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.279,674,873 - 9,690,286 (-)NCBI
Rnor_6.0 Ensembl712,541,061 - 12,741,296 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0712,541,032 - 12,741,314 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0712,711,159 - 12,910,971 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,187,348 - 11,202,717 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1711,187,782 - 11,203,831 (-)NCBI
Celera77,850,690 - 7,865,940 (-)NCBICelera
Cytogenetic Map7q11NCBI
ARHGAP45
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl191,065,923 - 1,086,628 (+)EnsemblGRCh38hg38GRCh38
GRCh38191,065,959 - 1,086,628 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37191,065,958 - 1,086,627 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36191,018,174 - 1,037,627 (+)NCBINCBI36hg18NCBI36
Celera191,000,157 - 1,019,602 (+)NCBI
Cytogenetic Map19p13.3NCBI
HuRef19839,303 - 860,108 (+)NCBIHuRef
CHM1_1191,065,515 - 1,087,432 (+)NCBICHM1_1
Arhgap45
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,852,505 - 79,867,305 (+)NCBIGRCm39mm39
GRCm39 Ensembl1079,852,487 - 79,867,306 (+)Ensembl
GRCm381080,016,672 - 80,031,471 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1080,016,653 - 80,031,472 (+)EnsemblGRCm38mm10GRCm38
MGSCv371079,479,417 - 79,494,216 (+)NCBIGRCm37mm9NCBIm37
MGSCv361079,422,804 - 79,434,597 (+)NCBImm8
Celera1081,031,479 - 81,046,279 (+)NCBICelera
Cytogenetic Map10C1NCBI
Arhgap45
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554956,797,302 - 6,815,651 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554956,800,988 - 6,815,941 (-)NCBIChiLan1.0ChiLan1.0
ARHGAP45
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1191,053,817 - 1,063,962 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01941,207 - 61,193 (-)NCBIMhudiblu_PPA_v0panPan3
ARHGAP45
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2057,657,154 - 57,787,713 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12057,656,693 - 57,668,324 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Arhgap45
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936588478,708 - 492,029 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGAP45
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,342,153 - 77,356,728 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1277,342,153 - 77,355,894 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,641,818 - 77,655,498 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARHGAP45
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.16823,109 - 842,697 (+)NCBI
ChlSab1.1 Ensembl6823,154 - 846,070 (+)Ensembl
Arhgap45
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248287,557,878 - 7,572,700 (-)NCBI

Position Markers
D7Rat64  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0712,687,850 - 12,688,006NCBIRnor6.0
Rnor_5.0712,857,572 - 12,857,728UniSTSRnor5.0
RGSC_v3.4711,379,355 - 11,379,511UniSTSRGSC3.4
RGSC_v3.4711,379,354 - 11,379,511RGDRGSC3.4
RGSC_v3.1711,379,355 - 11,379,511RGD
Celera78,041,153 - 8,041,297UniSTS
RH 3.4 Map744.9UniSTS
RH 3.4 Map744.9RGD
RH 2.0 Map70.0RGD
SHRSP x BN Map74.58RGD
Cytogenetic Map7q11UniSTS
RH128371  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01151,494,714 - 51,494,893NCBIRnor6.0
Rnor_6.0712,663,976 - 12,664,155NCBIRnor6.0
Rnor_5.01154,674,121 - 54,674,300UniSTSRnor5.0
Rnor_5.0712,833,698 - 12,833,877UniSTSRnor5.0
RGSC_v3.4711,355,477 - 11,355,656UniSTSRGSC3.4
RGSC_v3.41150,177,629 - 50,177,808UniSTSRGSC3.4
Celera1148,716,420 - 48,716,599UniSTS
Celera78,017,287 - 8,017,466UniSTS
Cytogenetic Map7q11UniSTS
RH94770  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0712,635,076 - 12,635,324NCBIRnor6.0
Rnor_5.0712,804,798 - 12,805,046UniSTSRnor5.0
RGSC_v3.4711,326,398 - 11,326,646UniSTSRGSC3.4
Celera77,988,756 - 7,989,005UniSTS
RH 3.4 Map741.1UniSTS
Cytogenetic Map7q11UniSTS
RH128461  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0712,631,993 - 12,632,198NCBIRnor6.0
Rnor_5.0712,801,715 - 12,801,920UniSTSRnor5.0
RGSC_v3.4711,323,315 - 11,323,520UniSTSRGSC3.4
Celera77,985,673 - 7,985,878UniSTS
Cytogenetic Map7q11UniSTS
RH130951  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0712,634,265 - 12,634,634NCBIRnor6.0
Rnor_5.0712,803,987 - 12,804,356UniSTSRnor5.0
RGSC_v3.4711,325,587 - 11,325,956UniSTSRGSC3.4
Celera77,987,945 - 7,988,314UniSTS
Cytogenetic Map7q11UniSTS
RH132727  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0712,541,220 - 12,541,437NCBIRnor6.0
Rnor_5.0712,711,323 - 12,711,540UniSTSRnor5.0
RGSC_v3.4711,187,512 - 11,187,729UniSTSRGSC3.4
Celera77,850,854 - 7,851,071UniSTS
RH 3.4 Map726.1UniSTS
Cytogenetic Map7q11UniSTS
RH133121  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0712,571,329 - 12,571,815NCBIRnor6.0
Rnor_5.0712,741,051 - 12,741,537UniSTSRnor5.0
RGSC_v3.4711,264,014 - 11,264,500UniSTSRGSC3.4
Celera77,925,711 - 7,926,197UniSTS
RH 3.4 Map741.3UniSTS
Cytogenetic Map7q11UniSTS
AW531576  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0712,643,537 - 12,643,750NCBIRnor6.0
Rnor_5.0712,813,259 - 12,813,472UniSTSRnor5.0
RGSC_v3.4711,334,547 - 11,334,760UniSTSRGSC3.4
Celera77,996,903 - 7,997,116UniSTS
Cytogenetic Map7q11UniSTS
RH139906  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0712,742,482 - 12,742,818NCBIRnor6.0
Rnor_5.0712,912,204 - 12,912,540UniSTSRnor5.0
RGSC_v3.4711,203,950 - 11,204,286UniSTSRGSC3.4
Celera77,867,173 - 7,867,509UniSTS
RH 3.4 Map740.7UniSTS
Cytogenetic Map7q11UniSTS
BE118278  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0712,620,735 - 12,621,258NCBIRnor6.0
Rnor_5.0712,790,457 - 12,790,980UniSTSRnor5.0
RGSC_v3.4711,312,056 - 11,312,579UniSTSRGSC3.4
Celera77,974,412 - 7,974,935UniSTS
RH 3.4 Map747.1UniSTS
Cytogenetic Map7q11UniSTS
Ptb  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0712,664,001 - 12,664,157NCBIRnor6.0
Rnor_6.01151,494,739 - 51,494,895NCBIRnor6.0
Rnor_5.01154,674,146 - 54,674,302UniSTSRnor5.0
Rnor_5.0712,833,723 - 12,833,879UniSTSRnor5.0
RGSC_v3.4711,355,502 - 11,355,658UniSTSRGSC3.4
RGSC_v3.41150,177,654 - 50,177,810UniSTSRGSC3.4
Celera1148,716,445 - 48,716,601UniSTS
Celera78,017,312 - 8,017,468UniSTS
Cytogenetic Map7q11UniSTS
AU048460  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0712,684,360 - 12,684,583NCBIRnor6.0
Rnor_5.0712,854,082 - 12,854,305UniSTSRnor5.0
RGSC_v3.4711,375,865 - 11,376,088UniSTSRGSC3.4
Celera78,037,663 - 8,037,886UniSTS
Cytogenetic Map7q11UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7134147172Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7134828535Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7134828535Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7137009673Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7138119654Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7265313832258115Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)72920071124838025Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7591147750911477Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7595196950951969Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7975804554758045Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)71164710256647102Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71232846767193263Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)712328467106995532Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71268785067801690Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:102
Count of miRNA genes:75
Interacting mature miRNAs:91
Transcripts:ENSRNOT00000060648
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 28 20 19 20 4 1 10 11
Low 1 43 29 21 21 8 11 70 34 31 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000060648   ⟹   ENSRNOP00000057381
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl712,541,061 - 12,741,296 (-)Ensembl
RefSeq Acc Id: NM_001108067   ⟹   NP_001101537
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.279,674,897 - 9,690,268 (-)NCBI
Rnor_6.0712,541,056 - 12,741,249 (-)NCBI
Rnor_5.0712,711,159 - 12,910,971 (-)NCBI
RGSC_v3.4711,187,348 - 11,202,717 (-)RGD
Celera77,850,690 - 7,865,940 (-)RGD
Sequence:
RefSeq Acc Id: XM_017594813   ⟹   XP_017450302
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.279,674,873 - 9,690,286 (-)NCBI
Rnor_6.0712,541,032 - 12,741,314 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039078978   ⟹   XP_038934906
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.279,674,873 - 9,690,064 (-)NCBI
RefSeq Acc Id: XM_039078979   ⟹   XP_038934907
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.279,674,873 - 9,690,064 (-)NCBI
RefSeq Acc Id: XM_039078980   ⟹   XP_038934908
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.279,674,873 - 9,685,219 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001101537   ⟸   NM_001108067
- UniProtKB: D4AAI2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450302   ⟸   XM_017594813
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000057381   ⟸   ENSRNOT00000060648
RefSeq Acc Id: XP_038934907   ⟸   XM_039078979
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038934906   ⟸   XM_039078978
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038934908   ⟸   XM_039078980
- Peptide Label: isoform X4
Protein Domains
F-BAR   Phorbol-ester/DAG-type   Rho-GAP

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695046
Promoter ID:EPDNEW_R5571
Type:multiple initiation site
Name:Arhgap45_1
Description:Rho GTPase activating protein 45
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0712,741,250 - 12,741,310EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
7 12871326 12871327 T G snv ACI/EurMcwi (MCW), FHH/EurMcwi (MCW)
7 12871654 12871655 G A snv GH/OmrMcwi (MCW)


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
7 11193781 11193782 T C snv GK/Ox (ICL)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308662 AgrOrtholog
Ensembl Genes ENSRNOG00000013220 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000057381 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000060648 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.10.555.10 UniProtKB/TrEMBL
  1.20.1270.60 UniProtKB/TrEMBL
InterPro AH/BAR-dom UniProtKB/TrEMBL
  F_BAR UniProtKB/TrEMBL
  FCH UniProtKB/TrEMBL
  Prot_Kinase_C-like_PE/DAG-bd UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/TrEMBL
  RhoGAP UniProtKB/TrEMBL
KEGG Report rno:314618 UniProtKB/TrEMBL
NCBI Gene 314618 ENTREZGENE
Pfam RhoGAP UniProtKB/TrEMBL
PhenoGen Arhgap45 PhenoGen
PROSITE F_BAR UniProtKB/TrEMBL
  RHOGAP UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/TrEMBL
SMART FCH UniProtKB/TrEMBL
  RhoGAP UniProtKB/TrEMBL
  SM00109 UniProtKB/TrEMBL
Superfamily-SCOP Rho_GAP UniProtKB/TrEMBL
  SSF103657 UniProtKB/TrEMBL
UniProt D4AAI2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-15 Arhgap45  Rho GTPase activating protein 45  Hmha1  histocompatibility (minor) HA-1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Hmha1  histocompatibility (minor) HA-1   Hmha1_predicted  histocompatibility (minor) HA-1 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Hmha1_predicted  histocompatibility (minor) HA-1 (predicted)  RGD1308662_predicted  similar to PTPL1-associated RhoGAP 1 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1308662_predicted  similar to PTPL1-associated RhoGAP 1 (predicted)  LOC314618_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC314618_predicted  similar to PTPL1-associated RhoGAP 1 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL