Arhgap45 (Rho GTPase activating protein 45) - Rat Genome Database

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Gene: Arhgap45 (Rho GTPase activating protein 45) Rattus norvegicus
Analyze
Symbol: Arhgap45
Name: Rho GTPase activating protein 45
RGD ID: 1308662
Description: Predicted to enable GTPase activator activity. Predicted to be involved in signal transduction. Predicted to be located in cytosol and plasma membrane. Predicted to be active in membrane. Orthologous to human ARHGAP45 (Rho GTPase activating protein 45); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: histocompatibility (minor) HA-1; Hmha1; LOC314618; minor histocompatibility protein HA-1; RGD1308662; rho GTPase-activating protein 45; similar to PTPL1-associated RhoGAP 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,325,515 - 10,340,955 (-)NCBIGRCr8
mRatBN7.279,674,873 - 9,690,286 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,674,897 - 9,690,268 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,557,673 - 12,572,710 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,433,011 - 14,448,046 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,294,131 - 12,309,172 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,541,032 - 12,741,314 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,541,061 - 12,741,296 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,711,159 - 12,910,971 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,187,348 - 11,202,717 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1711,187,782 - 11,203,831 (-)NCBI
Celera77,850,690 - 7,865,940 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acetamide  (EXP)
acetazolamide  (ISO)
acrylamide  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amiodarone  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
brinzolamide  (ISO)
buta-1,3-diene  (ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
carbon nanotube  (ISO)
cefepime  (ISO)
chromium(6+)  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
coumarin  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
hexane  (EXP)
indapamide  (ISO)
lead diacetate  (ISO)
lidocaine  (EXP)
methapyrilene  (ISO)
methylarsonic acid  (ISO)
nickel atom  (ISO)
ofloxacin  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
phenylmercury acetate  (ISO)
prednisolone  (ISO)
quercetin  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tetraphene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IEA,ISO)
membrane  (IBA)
plasma membrane  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19946888  


Genomics

Comparative Map Data
Arhgap45
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,325,515 - 10,340,955 (-)NCBIGRCr8
mRatBN7.279,674,873 - 9,690,286 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,674,897 - 9,690,268 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,557,673 - 12,572,710 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,433,011 - 14,448,046 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,294,131 - 12,309,172 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,541,032 - 12,741,314 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,541,061 - 12,741,296 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,711,159 - 12,910,971 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,187,348 - 11,202,717 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1711,187,782 - 11,203,831 (-)NCBI
Celera77,850,690 - 7,865,940 (-)NCBICelera
Cytogenetic Map7q11NCBI
ARHGAP45
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38191,065,959 - 1,086,628 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl191,065,923 - 1,086,628 (+)EnsemblGRCh38hg38GRCh38
GRCh37191,065,958 - 1,086,627 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36191,018,174 - 1,037,627 (+)NCBINCBI36Build 36hg18NCBI36
Celera191,000,157 - 1,019,602 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef19839,303 - 860,108 (+)NCBIHuRef
CHM1_1191,065,515 - 1,086,230 (+)NCBICHM1_1
T2T-CHM13v2.0191,030,624 - 1,051,294 (+)NCBIT2T-CHM13v2.0
Arhgap45
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,852,505 - 79,867,305 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,852,487 - 79,867,306 (+)EnsemblGRCm39 Ensembl
GRCm381080,016,672 - 80,031,471 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1080,016,653 - 80,031,472 (+)EnsemblGRCm38mm10GRCm38
MGSCv371079,479,417 - 79,494,216 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361079,422,804 - 79,434,597 (+)NCBIMGSCv36mm8
Celera1081,031,479 - 81,046,279 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Arhgap45
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554956,797,302 - 6,815,651 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554956,800,988 - 6,815,941 (-)NCBIChiLan1.0ChiLan1.0
ARHGAP45
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2205,402,945 - 5,423,096 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,639,516 - 4,659,610 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01941,207 - 61,193 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1191,053,817 - 1,063,962 (+)NCBIpanpan1.1PanPan1.1panPan2
ARHGAP45
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12057,656,693 - 57,668,324 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2057,657,154 - 57,787,713 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2057,458,893 - 57,470,543 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02058,398,796 - 58,410,450 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2058,398,800 - 58,409,442 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12057,454,098 - 57,465,745 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02057,933,623 - 57,945,275 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02058,136,680 - 58,148,331 (-)NCBIUU_Cfam_GSD_1.0
Arhgap45
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118217,342,748 - 217,356,296 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936588478,811 - 491,455 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936588478,708 - 492,029 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGAP45
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,342,156 - 77,356,837 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1277,342,153 - 77,355,894 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,641,818 - 77,655,498 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARHGAP45
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.16823,109 - 842,697 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl6823,154 - 846,070 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660818,013,711 - 8,034,490 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arhgap45
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248287,558,355 - 7,570,863 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248287,557,878 - 7,572,700 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Arhgap45
114 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:102
Count of miRNA genes:75
Interacting mature miRNAs:91
Transcripts:ENSRNOT00000060648
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat

Markers in Region
D7Rat64  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.279,866,467 - 9,866,624 (+)MAPPERmRatBN7.2
Rnor_6.0712,687,850 - 12,688,006NCBIRnor6.0
Rnor_5.0712,857,572 - 12,857,728UniSTSRnor5.0
RGSC_v3.4711,379,355 - 11,379,511UniSTSRGSC3.4
RGSC_v3.4711,379,354 - 11,379,511RGDRGSC3.4
RGSC_v3.1711,379,355 - 11,379,511RGD
Celera78,041,153 - 8,041,297UniSTS
RH 3.4 Map744.9UniSTS
RH 3.4 Map744.9RGD
RH 2.0 Map70.0RGD
SHRSP x BN Map74.58RGD
Cytogenetic Map7q11UniSTS
RH128371  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21149,050,008 - 49,050,188 (+)MAPPERmRatBN7.2
mRatBN7.279,842,584 - 9,842,764 (+)MAPPERmRatBN7.2
Rnor_6.0712,663,976 - 12,664,155NCBIRnor6.0
Rnor_6.01151,494,714 - 51,494,893NCBIRnor6.0
Rnor_5.01154,674,121 - 54,674,300UniSTSRnor5.0
Rnor_5.0712,833,698 - 12,833,877UniSTSRnor5.0
RGSC_v3.41150,177,629 - 50,177,808UniSTSRGSC3.4
RGSC_v3.4711,355,477 - 11,355,656UniSTSRGSC3.4
Celera78,017,287 - 8,017,466UniSTS
Celera1148,716,420 - 48,716,599UniSTS
Cytogenetic Map7q11UniSTS
RH94770  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.279,814,007 - 9,814,256 (+)MAPPERmRatBN7.2
Rnor_6.0712,635,076 - 12,635,324NCBIRnor6.0
Rnor_5.0712,804,798 - 12,805,046UniSTSRnor5.0
RGSC_v3.4711,326,398 - 11,326,646UniSTSRGSC3.4
Celera77,988,756 - 7,989,005UniSTS
RH 3.4 Map741.1UniSTS
Cytogenetic Map7q11UniSTS
RH128461  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.279,810,924 - 9,811,130 (+)MAPPERmRatBN7.2
Rnor_6.0712,631,993 - 12,632,198NCBIRnor6.0
Rnor_5.0712,801,715 - 12,801,920UniSTSRnor5.0
RGSC_v3.4711,323,315 - 11,323,520UniSTSRGSC3.4
Celera77,985,673 - 7,985,878UniSTS
Cytogenetic Map7q11UniSTS
RH130951  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.279,813,196 - 9,813,566 (+)MAPPERmRatBN7.2
Rnor_6.0712,634,265 - 12,634,634NCBIRnor6.0
Rnor_5.0712,803,987 - 12,804,356UniSTSRnor5.0
RGSC_v3.4711,325,587 - 11,325,956UniSTSRGSC3.4
Celera77,987,945 - 7,988,314UniSTS
Cytogenetic Map7q11UniSTS
RH132727  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.279,675,060 - 9,675,278 (+)MAPPERmRatBN7.2
Rnor_6.0712,541,220 - 12,541,437NCBIRnor6.0
Rnor_5.0712,711,323 - 12,711,540UniSTSRnor5.0
RGSC_v3.4711,187,512 - 11,187,729UniSTSRGSC3.4
Celera77,850,854 - 7,851,071UniSTS
RH 3.4 Map726.1UniSTS
Cytogenetic Map7q11UniSTS
RH133121  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.279,750,249 - 9,750,736 (+)MAPPERmRatBN7.2
Rnor_6.0712,571,329 - 12,571,815NCBIRnor6.0
Rnor_5.0712,741,051 - 12,741,537UniSTSRnor5.0
RGSC_v3.4711,264,014 - 11,264,500UniSTSRGSC3.4
Celera77,925,711 - 7,926,197UniSTS
RH 3.4 Map741.3UniSTS
Cytogenetic Map7q11UniSTS
AW531576  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.279,822,143 - 9,822,357 (+)MAPPERmRatBN7.2
Rnor_6.0712,643,537 - 12,643,750NCBIRnor6.0
Rnor_5.0712,813,259 - 12,813,472UniSTSRnor5.0
RGSC_v3.4711,334,547 - 11,334,760UniSTSRGSC3.4
Celera77,996,903 - 7,997,116UniSTS
Cytogenetic Map7q11UniSTS
RH139906  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.279,691,500 - 9,691,837 (+)MAPPERmRatBN7.2
Rnor_6.0712,742,482 - 12,742,818NCBIRnor6.0
Rnor_5.0712,912,204 - 12,912,540UniSTSRnor5.0
RGSC_v3.4711,203,950 - 11,204,286UniSTSRGSC3.4
Celera77,867,173 - 7,867,509UniSTS
RH 3.4 Map740.7UniSTS
Cytogenetic Map7q11UniSTS
BE118278  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.279,799,660 - 9,800,184 (+)MAPPERmRatBN7.2
Rnor_6.0712,620,735 - 12,621,258NCBIRnor6.0
Rnor_5.0712,790,457 - 12,790,980UniSTSRnor5.0
RGSC_v3.4711,312,056 - 11,312,579UniSTSRGSC3.4
Celera77,974,412 - 7,974,935UniSTS
RH 3.4 Map747.1UniSTS
Cytogenetic Map7q11UniSTS
Ptb  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21149,050,033 - 49,050,190 (+)MAPPERmRatBN7.2
mRatBN7.279,842,609 - 9,842,766 (+)MAPPERmRatBN7.2
Rnor_6.01151,494,739 - 51,494,895NCBIRnor6.0
Rnor_6.0712,664,001 - 12,664,157NCBIRnor6.0
Rnor_5.01154,674,146 - 54,674,302UniSTSRnor5.0
Rnor_5.0712,833,723 - 12,833,879UniSTSRnor5.0
RGSC_v3.41150,177,654 - 50,177,810UniSTSRGSC3.4
RGSC_v3.4711,355,502 - 11,355,658UniSTSRGSC3.4
Celera78,017,312 - 8,017,468UniSTS
Celera1148,716,445 - 48,716,601UniSTS
Cytogenetic Map7q11UniSTS
AU048460  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.279,862,976 - 9,863,200 (+)MAPPERmRatBN7.2
Rnor_6.0712,684,360 - 12,684,583NCBIRnor6.0
Rnor_5.0712,854,082 - 12,854,305UniSTSRnor5.0
RGSC_v3.4711,375,865 - 11,376,088UniSTSRGSC3.4
Celera78,037,663 - 8,037,886UniSTS
Cytogenetic Map7q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000060648   ⟹   ENSRNOP00000057381
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl79,674,897 - 9,690,268 (-)Ensembl
Rnor_6.0 Ensembl712,541,061 - 12,741,296 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115050   ⟹   ENSRNOP00000076374
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl79,674,897 - 9,687,630 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118662   ⟹   ENSRNOP00000078406
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl79,674,897 - 9,690,011 (-)Ensembl
RefSeq Acc Id: NM_001108067   ⟹   NP_001101537
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,325,539 - 10,340,908 (-)NCBI
mRatBN7.279,674,897 - 9,690,268 (-)NCBI
Rnor_6.0712,541,056 - 12,741,249 (-)NCBI
Rnor_5.0712,711,159 - 12,910,971 (-)NCBI
RGSC_v3.4711,187,348 - 11,202,717 (-)RGD
Celera77,850,690 - 7,865,940 (-)RGD
Sequence:
RefSeq Acc Id: XM_017594813   ⟹   XP_017450302
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,325,515 - 10,339,496 (-)NCBI
mRatBN7.279,674,873 - 9,690,286 (-)NCBI
Rnor_6.0712,541,032 - 12,741,314 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039078978   ⟹   XP_038934906
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,325,515 - 10,340,912 (-)NCBI
mRatBN7.279,674,873 - 9,690,064 (-)NCBI
RefSeq Acc Id: XM_039078979   ⟹   XP_038934907
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,325,515 - 10,340,912 (-)NCBI
mRatBN7.279,674,873 - 9,690,064 (-)NCBI
RefSeq Acc Id: XM_039078980   ⟹   XP_038934908
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,325,515 - 10,332,624 (-)NCBI
mRatBN7.279,674,873 - 9,685,219 (-)NCBI
RefSeq Acc Id: XM_063263414   ⟹   XP_063119484
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,325,515 - 10,340,955 (-)NCBI
RefSeq Acc Id: XR_010052965
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,330,702 - 10,340,932 (-)NCBI
RefSeq Acc Id: NP_001101537   ⟸   NM_001108067
- UniProtKB: D4AAI2 (UniProtKB/TrEMBL),   A6K8T3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450302   ⟸   XM_017594813
- Peptide Label: isoform X4
- UniProtKB: A0A8I5Y5N9 (UniProtKB/TrEMBL),   D4AAI2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000057381   ⟸   ENSRNOT00000060648
RefSeq Acc Id: XP_038934907   ⟸   XM_039078979
- Peptide Label: isoform X2
- UniProtKB: D4AAI2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934906   ⟸   XM_039078978
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZKS6 (UniProtKB/TrEMBL),   D4AAI2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934908   ⟸   XM_039078980
- Peptide Label: isoform X5
Ensembl Acc Id: ENSRNOP00000076374   ⟸   ENSRNOT00000115050
Ensembl Acc Id: ENSRNOP00000078406   ⟸   ENSRNOT00000118662
RefSeq Acc Id: XP_063119484   ⟸   XM_063263414
- Peptide Label: isoform X3
- UniProtKB: D4AAI2 (UniProtKB/TrEMBL)
Protein Domains
F-BAR   Phorbol-ester/DAG-type   Rho-GAP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AAI2-F1-model_v2 AlphaFold D4AAI2 1-1116 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695046
Promoter ID:EPDNEW_R5571
Type:multiple initiation site
Name:Arhgap45_1
Description:Rho GTPase activating protein 45
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0712,741,250 - 12,741,310EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308662 AgrOrtholog
BioCyc Gene G2FUF-34912 BioCyc
Ensembl Genes ENSRNOG00000013220 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000060648.4 UniProtKB/TrEMBL
  ENSRNOT00000115050.1 UniProtKB/TrEMBL
  ENSRNOT00000118662.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.555.10 UniProtKB/TrEMBL
  1.20.1270.60 UniProtKB/TrEMBL
InterPro AH/BAR-dom UniProtKB/TrEMBL
  C1-like_sf UniProtKB/TrEMBL
  F_BAR UniProtKB/TrEMBL
  FCH UniProtKB/TrEMBL
  Prot_Kinase_C-like_PE/DAG-bd UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/TrEMBL
  RhoGAP UniProtKB/TrEMBL
  RhoGAP UniProtKB/TrEMBL
KEGG Report rno:314618 UniProtKB/TrEMBL
NCBI Gene 314618 ENTREZGENE
PANTHER RHO GTPASE-ACTIVATING PROTEIN 45 UniProtKB/TrEMBL
  SPERMATHECAL PHYSIOLOGY VARIANT UniProtKB/TrEMBL
Pfam RhoGAP UniProtKB/TrEMBL
PhenoGen Arhgap45 PhenoGen
PROSITE F_BAR UniProtKB/TrEMBL
  RHOGAP UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013220 RatGTEx
SMART FCH UniProtKB/TrEMBL
  RhoGAP UniProtKB/TrEMBL
  SM00109 UniProtKB/TrEMBL
Superfamily-SCOP Rho_GAP UniProtKB/TrEMBL
  SSF103657 UniProtKB/TrEMBL
  SSF57889 UniProtKB/TrEMBL
UniProt A0A8I5Y5N9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZKS6 ENTREZGENE, UniProtKB/TrEMBL
  A6K8T3 ENTREZGENE, UniProtKB/TrEMBL
  D4AAI2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-15 Arhgap45  Rho GTPase activating protein 45  Hmha1  histocompatibility (minor) HA-1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Hmha1  histocompatibility (minor) HA-1   Hmha1_predicted  histocompatibility (minor) HA-1 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Hmha1_predicted  histocompatibility (minor) HA-1 (predicted)  RGD1308662_predicted  similar to PTPL1-associated RhoGAP 1 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1308662_predicted  similar to PTPL1-associated RhoGAP 1 (predicted)  LOC314618_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC314618_predicted  similar to PTPL1-associated RhoGAP 1 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL