Stkld1 (serine/threonine kinase-like domain containing 1) - Rat Genome Database

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Gene: Stkld1 (serine/threonine kinase-like domain containing 1) Rattus norvegicus
Analyze
Symbol: Stkld1
Name: serine/threonine kinase-like domain containing 1
RGD ID: 1307355
Description: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation. Orthologous to human STKLD1 (serine/threonine kinase like domain containing 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC311825; LOC311825; probable inactive protein kinase-like protein SgK071; RGD1307355; serine/threonine kinase-like domain-containing protein STKLD1; similar to gene model 711; similar to nima -related kinase (1C941); uncharacterized protein LOC311825
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8330,659,659 - 30,678,650 (+)NCBIGRCr8
mRatBN7.2310,261,583 - 10,280,850 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl310,261,828 - 10,280,566 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx313,321,826 - 13,340,565 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0321,907,227 - 21,925,966 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0320,162,528 - 20,181,267 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.035,481,524 - 5,500,568 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl35,481,522 - 5,500,583 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0310,843,542 - 10,863,228 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.435,830,687 - 5,849,484 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.135,836,030 - 5,850,402 (+)NCBI
Celera35,059,877 - 5,078,674 (+)NCBICelera
Cytogenetic Map3p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Stkld1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8330,659,659 - 30,678,650 (+)NCBIGRCr8
mRatBN7.2310,261,583 - 10,280,850 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl310,261,828 - 10,280,566 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx313,321,826 - 13,340,565 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0321,907,227 - 21,925,966 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0320,162,528 - 20,181,267 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.035,481,524 - 5,500,568 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl35,481,522 - 5,500,583 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0310,843,542 - 10,863,228 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.435,830,687 - 5,849,484 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.135,836,030 - 5,850,402 (+)NCBI
Celera35,059,877 - 5,078,674 (+)NCBICelera
Cytogenetic Map3p13NCBI
STKLD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389133,376,366 - 133,406,096 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9133,376,366 - 133,406,096 (+)EnsemblGRCh38hg38GRCh38
GRCh379136,243,237 - 136,271,220 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369135,233,105 - 135,261,041 (+)NCBINCBI36Build 36hg18NCBI36
Build 349133,272,837 - 133,300,773NCBI
Celera9106,793,768 - 106,821,789 (+)NCBICelera
Cytogenetic Map9q34.2NCBI
HuRef9105,743,194 - 105,773,047 (+)NCBIHuRef
CHM1_19136,393,410 - 136,421,727 (+)NCBICHM1_1
T2T-CHM13v2.09145,590,326 - 145,620,528 (+)NCBIT2T-CHM13v2.0
Stkld1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39226,823,533 - 26,843,508 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl226,824,059 - 26,843,508 (+)EnsemblGRCm39 Ensembl
GRCm38226,933,521 - 26,953,496 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl226,934,047 - 26,953,496 (+)EnsemblGRCm38mm10GRCm38
MGSCv37226,789,589 - 26,809,016 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36226,756,078 - 26,775,505 (+)NCBIMGSCv36mm8
Celera226,643,814 - 26,663,241 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map219.12NCBI
Stkld1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555132,726,339 - 2,744,998 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555132,726,339 - 2,745,099 (+)NCBIChiLan1.0ChiLan1.0
STKLD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2115,947,714 - 5,977,020 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan195,950,050 - 5,979,360 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09104,499,706 - 104,528,872 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19133,111,802 - 133,140,430 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9133,111,802 - 133,140,430 (+)Ensemblpanpan1.1panPan2
STKLD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1949,807,272 - 49,827,611 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl949,807,250 - 49,827,567 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha949,088,729 - 49,108,851 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0950,681,212 - 50,701,368 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl950,679,931 - 50,701,324 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1949,443,623 - 49,463,762 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0949,785,100 - 49,805,262 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0949,863,140 - 49,883,340 (+)NCBIUU_Cfam_GSD_1.0
Stkld1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947199,863,554 - 199,882,555 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366693,492,615 - 3,509,583 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366693,492,507 - 3,511,297 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STKLD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1272,995,842 - 273,011,443 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11272,988,767 - 273,012,007 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
STKLD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1124,732,267 - 4,763,687 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl124,732,772 - 4,759,244 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666058229,313 - 257,244 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stkld1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247601,835,478 - 1,850,864 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247601,833,797 - 1,851,379 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Stkld1
21 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:108
Count of miRNA genes:91
Interacting mature miRNAs:99
Transcripts:ENSRNOT00000031316
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3865816227494778Rat
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat

Markers in Region
RH131162  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2310,280,916 - 10,281,115 (+)MAPPERmRatBN7.2
Rnor_6.035,500,841 - 5,501,039NCBIRnor6.0
Rnor_5.0310,863,046 - 10,863,244UniSTSRnor5.0
RGSC_v3.435,849,757 - 5,849,955UniSTSRGSC3.4
Celera35,078,947 - 5,079,145UniSTS
Cytogenetic Map3p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 15 38 54 53 22 25 22 5 118 60 19 19 45 31

Sequence


Ensembl Acc Id: ENSRNOT00000031316   ⟹   ENSRNOP00000029627
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl310,262,754 - 10,280,566 (+)Ensembl
Rnor_6.0 Ensembl35,481,522 - 5,500,583 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099497   ⟹   ENSRNOP00000091000
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl310,261,828 - 10,280,566 (+)Ensembl
RefSeq Acc Id: NM_001395744   ⟹   NP_001382673
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8330,659,903 - 30,678,642 (+)NCBI
mRatBN7.2310,261,828 - 10,280,567 (+)NCBI
RefSeq Acc Id: XM_039105208   ⟹   XP_038961136
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8330,659,659 - 30,678,650 (+)NCBI
mRatBN7.2310,261,583 - 10,280,850 (+)NCBI
RefSeq Acc Id: XM_039105209   ⟹   XP_038961137
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8330,659,660 - 30,678,650 (+)NCBI
mRatBN7.2310,261,584 - 10,280,850 (+)NCBI
RefSeq Acc Id: XM_039105210   ⟹   XP_038961138
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8330,659,659 - 30,678,650 (+)NCBI
mRatBN7.2310,261,583 - 10,280,850 (+)NCBI
Ensembl Acc Id: ENSRNOP00000029627   ⟸   ENSRNOT00000031316
RefSeq Acc Id: XP_038961136   ⟸   XM_039105208
- Peptide Label: isoform X1
- UniProtKB: B1WBT9 (UniProtKB/TrEMBL),   F6R0A3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961138   ⟸   XM_039105210
- Peptide Label: isoform X3
- UniProtKB: B1WBT9 (UniProtKB/TrEMBL),   F6R0A3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961137   ⟸   XM_039105209
- Peptide Label: isoform X2
- UniProtKB: B1WBT9 (UniProtKB/TrEMBL),   F6R0A3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000091000   ⟸   ENSRNOT00000099497
RefSeq Acc Id: NP_001382673   ⟸   NM_001395744
- UniProtKB: A0A8J8XPK3 (UniProtKB/TrEMBL),   B1WBT9 (UniProtKB/TrEMBL),   F6R0A3 (UniProtKB/TrEMBL)
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F6R0A3-F1-model_v2 AlphaFold F6R0A3 1-674 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307355 AgrOrtholog
BioCyc Gene G2FUF-50317 BioCyc
Ensembl Genes ENSRNOG00000027911 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000031316.6 UniProtKB/TrEMBL
  ENSRNOT00000099497.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7133966 IMAGE-MGC_LOAD
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
MGC_CLONE MGC:187461 IMAGE-MGC_LOAD
NCBI Gene 311825 ENTREZGENE
PANTHER SERINE/THREONINE KINASE-LIKE DOMAIN-CONTAINING PROTEIN STKLD1 UniProtKB/TrEMBL
  SERINE/THREONINE PROTEIN KINASE UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PhenoGen Stkld1 PhenoGen
PROSITE PROTEIN_KINASE_DOM UniProtKB/TrEMBL
RatGTEx ENSRNOG00000027911 RatGTEx
Superfamily-SCOP ARM-type_fold UniProtKB/TrEMBL
  Kinase_like UniProtKB/TrEMBL
UniProt A0A8J8XPK3 ENTREZGENE, UniProtKB/TrEMBL
  B1WBT9 ENTREZGENE
  F6R0A3 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary B1WBT9 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-06-06 Stkld1  serine/threonine kinase-like domain containing 1  RGD1307355  similar to gene model 711  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1307355  similar to gene model 711  RGD1307355_predicted  similar to gene model 711 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-12-01   similar to gene model 711 (predicted)  RGD1307355_predicted  similar to nima -related kinase (1C941) (predicted)  Name updated 1299863 APPROVED
2005-01-20 RGD1307355_predicted  similar to nima -related kinase (1C941) (predicted)  LOC311825_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC311825_predicted  similar to nima -related kinase (1C941) (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL