Mertk (MER proto-oncogene, tyrosine kinase) - Rat Genome Database

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Gene: Mertk (MER proto-oncogene, tyrosine kinase) Rattus norvegicus
Analyze
Symbol: Mertk
Name: MER proto-oncogene, tyrosine kinase
RGD ID: 69283
Description: Predicted to enable transmembrane receptor protein tyrosine kinase activity. Involved in phagocytosis and positive regulation of phagocytosis. Located in photoreceptor outer segment. Used to study retinal degeneration. Human ortholog(s) of this gene implicated in retinitis pigmentosa 38. Orthologous to human MERTK (MER proto-oncogene, tyrosine kinase); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: c-mer proto-oncogene tyrosine kinase; proto-oncogene c-Mer; proto-oncogene tyrosine-protein kinase Mer; Rdy; receptor tyrosine kinase MerTK; Receptor tyrosine tinase gene probably the gene for Rdy; retinal dystrophy; tyrosine-protein kinase Mer
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Mertkrdy  
Genetic Models: RCS/Kyo
Is Marker For: Strains:   (LE x RCS-p+/LavRrrc)F1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83136,391,936 - 136,498,366 (+)NCBIGRCr8
mRatBN7.23115,939,351 - 116,045,141 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3115,939,351 - 116,046,554 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3119,836,222 - 119,942,080 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03128,431,776 - 128,537,642 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03126,092,272 - 126,198,124 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03121,235,230 - 121,340,932 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3121,235,119 - 121,342,444 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03128,669,534 - 128,777,078 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43116,308,387 - 116,416,414 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13116,213,959 - 116,321,987 (+)NCBI
Celera3114,768,654 - 114,872,632 (+)NCBICelera
Cytogenetic Map3q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
8-Br-cAMP  (ISO)
acrylamide  (ISO)
ADP  (ISO)
aflatoxin B1  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP)
bisphenol F  (ISO)
bleomycin A2  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
calix[6]arene  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chloroprene  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cypermethrin  (ISO)
cytarabine  (ISO)
dabigatran  (ISO)
DDD  (ISO)
DDE  (ISO)
DDT  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dieldrin  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
endrin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenofibrate  (ISO)
folic acid  (ISO)
gamma-hexachlorocyclohexane  (ISO)
lead diacetate  (EXP)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
methylisothiazolinone  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
propiconazole  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
topotecan  (EXP)
tremolite asbestos  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Mer receptor tyrosine kinase signaling participates in platelet function. Chen C, etal., Arterioscler Thromb Vasc Biol. 2004 Jun;24(6):1118-23. Epub 2004 May 6.
2. Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat. D'Cruz PM, etal., Hum Mol Genet 2000 Mar 1;9(4):645-51.
3. Mertk triggers uptake of photoreceptor outer segments during phagocytosis by cultured retinal pigment epithelial cells. Feng W, etal., J Biol Chem 2002 May 10;277(19):17016-22. Epub 2002 Feb 22.
4. Focal adhesion kinase signaling promotes phagocytosis of integrin-bound photoreceptors. Finnemann SC EMBO J 2003 Aug 15;22(16):4143-54.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Correction of the retinal dystrophy phenotype of the RCS rat by viral gene transfer of Mertk. Vollrath D, etal., Proc Natl Acad Sci U S A 2001 Oct 23;98(22):12584-9.
Additional References at PubMed
PMID:1299193   PMID:10227296   PMID:11452127   PMID:15180281   PMID:15650770   PMID:16751775   PMID:17442946   PMID:18159085   PMID:18393392   PMID:18395422   PMID:19204785   PMID:20238011  
PMID:21052544   PMID:22871113   PMID:23353780   PMID:23878224   PMID:26283020   PMID:26458944   PMID:28210098   PMID:28500071   PMID:29440417   PMID:29659094   PMID:30054542   PMID:34440696  
PMID:34829984   PMID:38588709   PMID:38783191  


Genomics

Comparative Map Data
Mertk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83136,391,936 - 136,498,366 (+)NCBIGRCr8
mRatBN7.23115,939,351 - 116,045,141 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3115,939,351 - 116,046,554 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3119,836,222 - 119,942,080 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03128,431,776 - 128,537,642 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03126,092,272 - 126,198,124 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03121,235,230 - 121,340,932 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3121,235,119 - 121,342,444 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03128,669,534 - 128,777,078 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43116,308,387 - 116,416,414 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13116,213,959 - 116,321,987 (+)NCBI
Celera3114,768,654 - 114,872,632 (+)NCBICelera
Cytogenetic Map3q36NCBI
MERTK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382111,898,607 - 112,029,561 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2111,898,607 - 112,029,561 (+)EnsemblGRCh38hg38GRCh38
GRCh372112,656,184 - 112,787,138 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362112,372,662 - 112,503,416 (+)NCBINCBI36Build 36hg18NCBI36
Build 342112,372,415 - 112,503,168NCBI
Celera2106,258,379 - 106,389,184 (-)NCBICelera
Cytogenetic Map2q13NCBI
HuRef2105,169,541 - 105,300,438 (+)NCBIHuRef
CHM1_12112,661,190 - 112,791,926 (+)NCBICHM1_1
T2T-CHM13v2.02112,325,012 - 112,456,507 (+)NCBIT2T-CHM13v2.0
Mertk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392128,540,836 - 128,645,082 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2128,540,876 - 128,644,814 (+)EnsemblGRCm39 Ensembl
GRCm382128,698,915 - 128,803,162 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2128,698,956 - 128,802,894 (+)EnsemblGRCm38mm10GRCm38
MGSCv372128,524,733 - 128,627,923 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362128,390,438 - 128,493,628 (+)NCBIMGSCv36mm8
Celera2129,929,620 - 130,029,340 (+)NCBICelera
Cytogenetic Map2F1NCBI
cM Map262.63NCBI
Mertk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554702,065,411 - 2,167,909 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554702,065,468 - 2,167,909 (-)NCBIChiLan1.0ChiLan1.0
MERTK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21216,046,414 - 16,179,196 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A16,049,177 - 16,181,960 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A89,977,226 - 90,109,970 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A113,055,554 - 113,162,556 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A113,056,852 - 113,162,052 (+)Ensemblpanpan1.1panPan2
MERTK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11736,336,787 - 36,445,796 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1736,336,861 - 36,445,380 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1736,106,597 - 36,218,038 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01737,111,333 - 37,223,997 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1737,111,394 - 37,223,995 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11736,231,212 - 36,343,496 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01736,303,304 - 36,415,155 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01736,515,620 - 36,628,095 (+)NCBIUU_Cfam_GSD_1.0
Mertk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629281,712,891 - 81,810,395 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936783607,382 - 704,889 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936783607,425 - 704,879 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MERTK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl344,349,385 - 44,483,402 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1344,349,377 - 44,483,400 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2345,947,411 - 45,961,016 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MERTK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11414,971,858 - 15,100,736 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1415,001,471 - 15,101,025 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660804,589,380 - 4,720,259 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mertk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624749341,289 - 443,640 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624749337,441 - 444,730 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mertk
714 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:233
Count of miRNA genes:172
Interacting mature miRNAs:198
Transcripts:ENSRNOT00000023419
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)3115638168135181505Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3112287552135181505Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat

Markers in Region
AU048840  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23115,948,841 - 115,949,055 (+)MAPPERmRatBN7.2
Rnor_6.03121,244,720 - 121,244,933NCBIRnor6.0
Rnor_5.03128,767,375 - 128,767,588UniSTSRnor5.0
RGSC_v3.43116,317,877 - 116,318,090UniSTSRGSC3.4
Celera3114,778,144 - 114,778,357UniSTS
Cytogenetic Map3q36UniSTS
MERTK  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23116,036,473 - 116,038,063 (+)MAPPERmRatBN7.2
Rnor_6.03121,332,265 - 121,333,854NCBIRnor6.0
Rnor_5.03128,678,440 - 128,680,029UniSTSRnor5.0
RGSC_v3.43116,407,747 - 116,409,336UniSTSRGSC3.4
Celera3114,863,955 - 114,865,544UniSTS
Cytogenetic Map3q36UniSTS


Related Rat Strains
The following Strains have been annotated to Mertk
(LE x RCS-p+/LavRrrc)F1    


Genetic Models
This gene Mertk is modified in the following models/strains:
RCS/Kyo    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 43 40 42 40 72 83 21 43
Low 19 141 184 107 27 107 36 45 178 32 124 24
Below cutoff

Sequence


Ensembl Acc Id: ENSRNOT00000023419   ⟹   ENSRNOP00000023419
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3115,968,752 - 116,046,554 (+)Ensembl
Rnor_6.0 Ensembl3121,235,119 - 121,342,444 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097978   ⟹   ENSRNOP00000076826
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3115,939,351 - 116,046,554 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107394   ⟹   ENSRNOP00000082953
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3115,944,529 - 116,046,554 (+)Ensembl
RefSeq Acc Id: NM_022943   ⟹   NP_075232
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83136,392,574 - 136,498,366 (+)NCBI
mRatBN7.23115,939,351 - 116,045,141 (+)NCBI
Rnor_6.03121,235,230 - 121,340,932 (+)NCBI
Rnor_5.03128,669,534 - 128,777,078 (-)NCBI
RGSC_v3.43116,308,387 - 116,416,414 (+)RGD
Celera3114,768,654 - 114,872,632 (+)RGD
Sequence:
RefSeq Acc Id: XM_063284527   ⟹   XP_063140597
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83136,391,936 - 136,480,115 (+)NCBI
RefSeq Acc Id: NP_075232   ⟸   NM_022943
- Peptide Label: precursor
- UniProtKB: P57097 (UniProtKB/Swiss-Prot),   A6HQ37 (UniProtKB/TrEMBL),   A0A8I5ZYY3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023419   ⟸   ENSRNOT00000023419
Ensembl Acc Id: ENSRNOP00000076826   ⟸   ENSRNOT00000097978
Ensembl Acc Id: ENSRNOP00000082953   ⟸   ENSRNOT00000107394
RefSeq Acc Id: XP_063140597   ⟸   XM_063284527
- Peptide Label: isoform X1
Protein Domains
Fibronectin type-III   Ig-like   Ig-like C2-type   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P57097-F1-model_v2 AlphaFold P57097 1-994 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692414
Promoter ID:EPDNEW_R2939
Type:multiple initiation site
Name:Mertk_1
Description:MER proto-oncogene, tyrosine kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03121,235,112 - 121,235,172EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69283 AgrOrtholog
BioCyc Gene G2FUF-47937 BioCyc
Ensembl Genes ENSRNOG00000017319 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055005926 UniProtKB/Swiss-Prot
  ENSRNOG00060016090 UniProtKB/Swiss-Prot
  ENSRNOG00065014153 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023419.5 UniProtKB/TrEMBL
  ENSRNOT00000097978.1 UniProtKB/Swiss-Prot
  ENSRNOT00000107394.1 UniProtKB/TrEMBL
  ENSRNOT00055009610 UniProtKB/Swiss-Prot
  ENSRNOT00060027596 UniProtKB/Swiss-Prot
  ENSRNOT00065023398 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Immunoglobulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RTK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:65037 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 65037 ENTREZGENE
PANTHER TYROSINE-PROTEIN KINASE MER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam fn3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00047 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
PhenoGen Mertk PhenoGen
PRINTS TYRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017319 RatGTEx
  ENSRNOG00055005926 RatGTEx
  ENSRNOG00060016090 RatGTEx
  ENSRNOG00065014153 RatGTEx
SMART FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1L5L8Q5_RAT UniProtKB/TrEMBL
  A0A8I5ZYY3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QC30_RAT UniProtKB/TrEMBL
  A6HQ37 ENTREZGENE, UniProtKB/TrEMBL
  A6HQ38_RAT UniProtKB/TrEMBL
  MERTK_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9JL63_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-10 Mertk  MER proto-oncogene, tyrosine kinase  Mertk  c-mer proto-oncogene tyrosine kinase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-06-06 Mertk  c-mer proto-oncogene tyrosine kinase  Rdy  retinal dystrophy  Data merged from RGD:3550 737654 APPROVED
2003-04-09 Rdy  retinal dystrophy    Retinal dystrophy  Name updated 629478 APPROVED
2002-06-10 Rdy  Retinal dystrophy      Symbol and Name status set to approved 70586 APPROVED
2002-06-10 Mertk  c-mer proto-oncogene tyrosine kinase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease mutation causes the retinal dystrophy (rdy) phenotype in the Royal College of Surgeons (RCS) rat 69668
gene_disease mutation causes the retinal dystrophy (rdy) phenotype in the Royal College of Surgeons (RCS) rat 1299193
gene_function tyrosine kinase receptor 61793
gene_function tyrosine kinase receptor 69668
gene_mutations_overexpression gene transfer corrects a defect in retinal pigment epithelium (RPE) phagocytosis in the retinal dystrophy (rdy) locus of the Royal College of Surgeons (RCS) rat by restoring normal phagocytosis of shed photoreceptor outer segments 69668
gene_mutations_overexpression gene transfer to the eyes of young Royal College of Surgeons (RCS) rats with (rdy) retinal dystrophy increases sensitivity to low intensity light 69668
gene_process required for proper retina functioning 61793
gene_process required for proper retina functioning 69668
gene_process involved as a signaling molecule triggering outer segment uptake during phagocytosis 1299193
gene_product member of the axl family 61793
gene_product member of the axl family 69668
gene_protein 994 amino acids 61793
gene_protein 994 amino acids 69668