Mertk (MER proto-oncogene, tyrosine kinase)

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Gene: Mertk (MER proto-oncogene, tyrosine kinase) Rattus norvegicus

Analyze

Symbol:

Mertk

Name:

MER proto-oncogene, tyrosine kinase

RGD ID:

69283

Description:

Predicted to have ATP binding activity. Involved in phagocytosis; positive regulation of phagocytosis; and protein phosphorylation. Localizes to photoreceptor outer segment. Used to study retinal degeneration. Human ortholog(s) of this gene implicated in retinitis pigmentosa 38. Orthologous to human MERTK (MER proto-oncogene, tyrosine kinase); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

c-mer proto-oncogene tyrosine kinase; proto-oncogene c-Mer; proto-oncogene tyrosine-protein kinase Mer; Rdy; receptor tyrosine kinase MerTK; Receptor tyrosine tinase gene probably the gene for Rdy; retinal dystrophy; tyrosine-protein kinase Mer

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Allele / Splice:

Mertk^rdy

Genetic Models:

RCS/Kyo

Is Marker For:

Strains: (LE x RCS-p⁺/LavRrrc)F1

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	115,939,351 - 116,045,141 (+)	NCBI
Rnor_6.0 Ensembl	3	121,235,119 - 121,342,444 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	3	121,235,230 - 121,340,932 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	3	128,669,534 - 128,777,078 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	116,308,387 - 116,416,414 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	3	116,213,959 - 116,321,987 (+)	NCBI
Celera	3	114,768,654 - 114,872,632 (+)	NCBI		Celera
Cytogenetic Map	3	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

carcinoma (ISO)

COVID-19 (ISO)

fundus dystrophy (ISO)

genetic disease (ISO)

IgA glomerulonephritis (ISO)

pulmonary embolism (ISO)

retinal degeneration (IAGP,IDA)

retinitis pigmentosa (ISO)

retinitis pigmentosa 38 (ISO)

Thromboembolism (ISO)

thrombosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (ISO)

5-aza-2'-deoxycytidine (ISO)

8-Br-cAMP (ISO)

ADP (ISO)

aflatoxin B1 (ISO)

aldrin (ISO)

ammonium chloride (EXP)

antirheumatic drug (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

bisphenol F (ISO)

bleomycin A2 (ISO)

calcitriol (ISO)

calix[6]arene (ISO)

carbon nanotube (ISO)

chloroprene (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

clobetasol (ISO)

clofibrate (ISO)

copper atom (ISO)

copper(0) (ISO)

crocidolite asbestos (ISO)

cypermethrin (ISO)

cytarabine (ISO)

dabigatran (ISO)

DDD (ISO)

DDE (ISO)

DDT (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

dieldrin (ISO)

disodium selenite (ISO)

doxorubicin (ISO)

endosulfan (EXP)

endrin (ISO)

ethanol (ISO)

fenofibrate (ISO)

folic acid (ISO)

gamma-hexachlorocyclohexane (ISO)

lead diacetate (EXP)

lipopolysaccharide (ISO)

methylisothiazolinone (ISO)

nickel atom (ISO)

nickel dichloride (ISO)

oxaliplatin (EXP)

paracetamol (ISO)

paraquat (ISO)

phorbol 13-acetate 12-myristate (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

propiconazole (ISO)

rotenone (EXP)

serpentine asbestos (ISO)

silicon dioxide (ISO)

simvastatin (ISO)

sodium arsenite (ISO)

sodium dichromate (ISO)

sulforaphane (ISO)

sunitinib (ISO)

tamoxifen (ISO)

testosterone (ISO)

tetrachloromethane (ISO)

topotecan (EXP)

tremolite asbestos (ISO)

trichostatin A (ISO)

triclosan (ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

apoptotic cell clearance (ISO)

cell migration (IBA)

multicellular organism development (IBA)

natural killer cell differentiation (ISO)

negative regulation of cytokine production (ISO)

negative regulation of leukocyte apoptotic process (ISO)

negative regulation of lymphocyte activation (ISO)

nervous system development (IBA)

neutrophil clearance (ISO)

peptidyl-tyrosine phosphorylation (IEA)

phagocytosis (IBA,IDA,IMP,ISO)

platelet activation (ISO)

positive regulation of kinase activity (IBA)

positive regulation of phagocytosis (IDA,ISO)

protein kinase B signaling (ISO)

protein phosphorylation (IDA)

retina development in camera-type eye (ISO)

secretion by cell (ISO)

spermatogenesis (ISO)

substrate adhesion-dependent cell spreading (ISO)

transmembrane receptor protein tyrosine kinase signaling pathway (IBA)

vagina development (ISO)

Cellular Component

cytoplasm (ISO)

extracellular space (ISO)

integral component of plasma membrane (IBA)

photoreceptor outer segment (IDA)

receptor complex (IBA)

rhabdomere (ISO)

Molecular Function

ATP binding (IEA)

protein binding (ISO)

transmembrane receptor protein tyrosine kinase activity (IBA,NAS)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal retinal pigment epithelium morphology (IAGP)

retinal photoreceptor degeneration (IAGP)

thin retinal outer nuclear layer (IAGP)

References

References - curated


1.	Chen C, etal., Arterioscler Thromb Vasc Biol. 2004 Jun;24(6):1118-23. Epub 2004 May 6.
2.	D'Cruz PM, etal., Hum Mol Genet 2000 Mar 1;9(4):645-51.
3.	Feng W, etal., J Biol Chem 2002 May 10;277(19):17016-22. Epub 2002 Feb 22.
4.	Finnemann SC EMBO J 2003 Aug 15;22(16):4143-54.
5.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6.	GOA data from the GO Consortium
7.	MGD data from the GO Consortium
8.	NCBI rat LocusLink and RefSeq merged data July 26, 2002
9.	OMIM Disease Annotation Pipeline
10.	RGD automated data pipeline
11.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12.	RGD automated import pipeline for gene-chemical interactions
13.	Vollrath D, etal., Proc Natl Acad Sci U S A 2001 Oct 23;98(22):12584-9.

Additional References at PubMed

PMID:1299193	PMID:10227296	PMID:11452127	PMID:15180281	PMID:15650770	PMID:16751775	PMID:17442946	PMID:18159085	PMID:18393392	PMID:18395422	PMID:19204785	PMID:20238011
PMID:21052544	PMID:22871113	PMID:23353780	PMID:23878224	PMID:26283020	PMID:26458944	PMID:28210098	PMID:28500071	PMID:29440417	PMID:29659094	PMID:30054542

Genomics

Comparative Map Data

Mertk
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	115,939,351 - 116,045,141 (+)	NCBI
Rnor_6.0 Ensembl	3	121,235,119 - 121,342,444 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	3	121,235,230 - 121,340,932 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	3	128,669,534 - 128,777,078 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	116,308,387 - 116,416,414 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	3	116,213,959 - 116,321,987 (+)	NCBI
Celera	3	114,768,654 - 114,872,632 (+)	NCBI		Celera
Cytogenetic Map	3	q36	NCBI

MERTK
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	2	111,898,607 - 112,029,561 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	2	111,898,607 - 112,029,561 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	2	112,656,184 - 112,787,138 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	112,372,662 - 112,503,416 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	2	112,372,415 - 112,503,168	NCBI
Celera	2	106,258,379 - 106,389,184 (-)	NCBI
Cytogenetic Map	2	q13	NCBI
HuRef	2	105,169,541 - 105,300,438 (+)	NCBI		HuRef
CHM1_1	2	112,661,190 - 112,791,926 (+)	NCBI		CHM1_1

Mertk
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	128,540,835 - 128,645,082 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	2	128,540,876 - 128,644,814 (+)	Ensembl
GRCm38	2	128,698,915 - 128,803,162 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	128,698,956 - 128,802,894 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	128,524,733 - 128,627,923 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	2	128,390,438 - 128,493,628 (+)	NCBI			mm8
Celera	2	129,929,620 - 130,029,340 (+)	NCBI		Celera
Cytogenetic Map	2	F1	NCBI

Mertk
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955470	2,065,411 - 2,167,909 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955470	2,065,468 - 2,167,909 (-)	NCBI	ChiLan1.0	ChiLan1.0

MERTK
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	2A	113,055,554 - 113,162,556 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	113,056,852 - 113,162,052 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	2A	89,977,226 - 90,109,970 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

MERTK
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	17	36,336,861 - 36,445,380 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	17	36,336,787 - 36,445,796 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Mertk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936783	607,425 - 704,879 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MERTK
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	44,349,380 - 44,483,402 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	44,349,377 - 44,483,400 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	45,947,411 - 45,961,016 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MERTK
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	14,971,858 - 15,100,736 (+)	NCBI
ChlSab1.1 Ensembl	14	15,001,471 - 15,101,025 (+)	Ensembl

Mertk
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624749	337,441 - 444,730 (-)	NCBI

Position Markers

AU048840

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	3	121,244,720 - 121,244,933	NCBI	Rnor6.0
Rnor_5.0	3	128,767,375 - 128,767,588	UniSTS	Rnor5.0
RGSC_v3.4	3	116,317,877 - 116,318,090	UniSTS	RGSC3.4
Celera	3	114,778,144 - 114,778,357	UniSTS
Cytogenetic Map	3	q36	UniSTS

MERTK

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	3	121,332,265 - 121,333,854	NCBI	Rnor6.0
Rnor_5.0	3	128,678,440 - 128,680,029	UniSTS	Rnor5.0
RGSC_v3.4	3	116,407,747 - 116,409,336	UniSTS	RGSC3.4
Celera	3	114,863,955 - 114,865,544	UniSTS
Cytogenetic Map	3	q36	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	10639528	127023997	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	10639528	127023997	Rat
737818	Hcar12	Hepatocarcinoma resistance QTL 12	2.6		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	3	30114912	123700444	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	30846101	172879276	Rat
1358362	Srcrt2	Stress Responsive Cort QTL 2	2.78		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	39248391	140271184	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	43295930	163640485	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	43295930	163640485	Rat
1581503	Cm58	Cardiac mass QTL 58	2.7	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	45406058	127023997	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	45406058	177699992	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	48561928	155263151	Rat
631665	Bw8	Body weight QTL 8	5.5		body mass (VT:0001259)	body weight (CMO:0000012)	3	51821836	124513579	Rat
1581568	Rf53	Renal function QTL 53			total urine protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	3	58204463	170534769	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	61241033	165369047	Rat
1300111	Rf12	Renal function QTL 12	3.78		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	62922868	127023997	Rat
12879848	Bw181	Body weght QTL 181		0.015	body mass (VT:0001259)	body weight (CMO:0000012)	3	72672290	127023997	Rat
2301414	Kidm37	Kidney mass QTL 37		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	72973445	127023997	Rat
1600376	Arunc5	Aerobic running capacity QTL 5		0.21	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	3	78700444	123700444	Rat
1581546	Pur13	Proteinuria QTL 13	2.93	0.0335	total urine protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	3	81136227	154416635	Rat
7387306	Bw124	Body weight QTL 124	3.2	0.0003	body mass (VT:0001259)	body weight (CMO:0000012)	3	88910015	133910015	Rat
631649	Bp123	Blood pressure QTL 123	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	94788365	139788365	Rat
8694437	Bw167	Body weight QTL 167	22.46	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	3	97009185	142009185	Rat
631841	Niddm39	Non-insulin dependent diabetes mellitus QTL 39	3.36		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	99465522	168732722	Rat
724532	Cm17	Cardiac mass QTL 17	2		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	3	101058963	146058963	Rat
2293087	Iddm27	Insulin dependent diabetes mellitus QTL 27	2.68		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	102152812	155263151	Rat
1354611	Despr2	Despair related QTL 2	3.03	0.0028	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	3	102466149	147466149	Rat
2312659	Slep7	Serum leptin concentration QTL 7		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	3	103141814	176418101	Rat
2312670	Bw94	Body weight QTL 94		0.01	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	3	103141814	176418101	Rat
2312673	Scl63	Serum cholesterol level QTL 63		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	103141814	176418101	Rat
2302373	Gluco39	Glucose level QTL 39	5.01		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	3	103141944	170934860	Rat
619618	Rf3	Renal disease susceptibility QTL 3	6.5	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate to body weight ratio (CMO:0001270)	3	114376250	159376250	Rat
1331758	Bp207	Blood pressure QTL 207	2.848		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	117303473	141971336	Rat
1578754	Stresp16	Stress response QTL 16	4	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	3	119471263	164471263	Rat
1358204	Insglur1	Insulin/glucose ratio QTL 1	3.8		blood glucose amount (VT:0000188)	serum glucose level (CMO:0000543)	3	120917788	141971336	Rat
1358204	Insglur1	Insulin/glucose ratio QTL 1	3.8		blood glucose amount (VT:0000188)	serum insulin level (CMO:0000358)	3	120917788	141971336	Rat

Related Rat Strains

The following Strains have been annotated to Mertk

(LE x RCS-p⁺/LavRrrc)F1

Genetic Models

This gene Mertk is modified in the following models/strains

RCS/Kyo

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	233
Count of miRNA genes:	172
Interacting mature miRNAs:	198
Transcripts:	ENSRNOT00000023419
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium			13	12	12	12			20	27	7	11
Low	3	43	44	29	7	29	8	11	54	8	34		8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_022943	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF208235	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF208236	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ221127	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000118	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KY305009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000023419 ⟹ ENSRNOP00000023419

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	3	121,235,119 - 121,342,444 (+)	Ensembl

RefSeq Acc Id:

NM_022943 ⟹ NP_075232

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	115,939,351 - 116,045,141 (+)	NCBI
Rnor_6.0	3	121,235,230 - 121,340,932 (+)	NCBI
Rnor_5.0	3	128,669,534 - 128,777,078 (-)	NCBI
RGSC_v3.4	3	116,308,387 - 116,416,414 (+)	RGD
Celera	3	114,768,654 - 114,872,632 (+)	RGD

Sequence:

show sequence

CATCTGTCCGGAGAGAACTGCCAGATCCGCGGCCCCGCGATGGTTCTGGCCCCACTACTGCTGG
GGCTGCTGCTGCTATCCGCACTCTGGAATGGAGGCACTGCTGAAAAGGAGGAAGAAATCAAGCC
AGATCAGCCATTTTCAGGGCCTTTACCAGGGAGCCTACCAGCTGACCACAGGCCATTCTTCGCC
CCTCACTCCAGTGGGGACCAGCTGTCACCATCCCAGACTGGAAGATCACATCCAGCACACACAG
CCACTCCCCAGATGACCTCTGCAGCATCAAACCTCCTGCCTCCTGTTGCATTTAAAAACACAAT
TGGACGCATAGTACTTTCGGAACATAAAAGTGTCAAATTTAATTGCTCGATCAACATTCCTAAC
GTGTATCAAGAAACAGCTGGCATTTCGTGGTGGAAAGATGGAAAGGAACTGCTTGGGGCACATC
ATTCAATCACACAGTTTTATCCTGATGAGGAAGGGGTATCAATAATTGCATTGTTCAGCATAAC
CAGTGTGCAGCGCTCAGACAATGGGTCGTACATCTGTAAGATGAAGGTGAACGATAGAGAGGTT
GTGTCTGATCCCATATACGTGGAAGTCCAAGGACTCCCTTACTTTACTAAGCAGCCTGAGAGCG
TGAATGTCACCAGAAACACAGCCTTCAACCTCACCTGCCAGGCTGTGGGACCCCCTGAGCCCGT
CAACATCTTCTGGGTTCAAAATAGCAGCCGTGTTAATGAAAATCCAGAAAGGTCCCCGTCTGTC
CTAACTGTCGCTGGTCTGACAGAGACCGCAGTCTTCAGCTGTGAGGCCCACAACGACAAAGGAC
TGACGGTGTCCAAGGGTGTACAGATCAACATCAAAGTCATCCCTTCCCCACCCACTGAAGTCCA
TATCCTCAACAGCACAGCGCACAGCATCCTGGTCTCCTGGGTCCCAGGGTTTGATGGCTACTCC
CCACTTCAGAACTGCAGCATTCAGGTCAAGGAAGCTGACCAGCTGAGTAATGGCTCAGTCATGG
TTTTTAATACCTCTGCTTCGCCACATCTGTATGAAGTCCAGCAGCTGCAAGCCCTGGCTAATTA
CAGCGTCACTGTGTCCTGTCGGAATGAGATTGGCTGGTCTGCAGTGAGCCCTTGGATCCTGGCC
AGCACTACAGAAGGAGCTCCAGCAGTGGCGCCTCTAAACATCACTGTGTTTCTGAACGAATCCA
GCAACAACCTGGAAATCAGATGGACGAAGCCTCCAATTAAGCGGCAGGATGGGGAACTGGTGGG
CTACCGGATATCTCACGTGTGGGAGAGTGCGGGGACTTCCAAAGAGCTTTCTGAAGAAGTCAGC
CAGAATGGCAGCTGGGCTCAGGTTCCTGTCCAAATGCACAATGCCACCTGCACAGTGAGAATCG
CCGTCATCACTAAAGGGGGCATTGGGCCCTTCAGTGAGCCAGTGGACGTAGCCATTCCGGAGCA
CAGTAGGGTAGATTACGCACCCTCATCAACCCCAGCCCCTGGCAACACCGAGTCTATGCTCATC
ATCCTGGGCTGCTTCTGCGGGTTTGTTCTCATGGGGTTGATTCTGTATCTTTCTCTGGCCATCA
AAAGGAGAGTCCAGGAAACAAAGTTTGGGGGTGCATTCTCCGAGGAGGACTCCCAATTAGTTGT
AAATTACAGAGCAAAGAAGTCCTTCTGTCGGCGAGCCATCGAGCTTACCTTGCAAAGCCTGGGG
GTGAGCGAGGAGCTGCAAAACAAGCTAGAAGATGTTGTGGTTGACAGAAATCTTCTAATTCTTG
GGAAAGTTCTGGGCGAAGGAGAGTTTGGGTCTGTAATGGAAGGAAATCTGAAGCAGGAAGATGG
GACTTCTCAGAAGGTGGCAGTGAAGACCATGAAGTTGGACAACTTTTCTCTACGGGAGATCGAG
GAGTTTCTCAGCGAAGCAGCGTGCATGAAAGACTTCAATCACCCAAACGTCATCCGGCTTCTAG
GCGTGTGTATAGAACTGAGCTCTCAAGGCATCCCGAAGCCCATGGTGATTTTACCCTTCATGAA
ATACGGAGACCTCCACACCTTCCTGCTATATTCCCGGATAGAATCAGTACCGAAGTCCATCCCC
CTGCAGACACTGCTGAAGTTCATGGTGGACATTGCCCAGGGAATGGAGTACCTGAGCAGCAGGA
ATTTTCTCCACAGGGATTTAGCTGCTCGGAATTGCATGTTGCGGGATGACATGACTGTCTGCGT
GGCAGACTTTGGCCTCTCTAAGAAGATTTACAGTGGTGATTATTACCGCCAAGGCCGCATTGCC
AAAATGCCTGTGAAGTGGATCGCCATAGAGAGCCTGGCGGACCGAGTCTACACAAGCAAGAGTG
ACGTGTGGGCTTTTGGCGTGACCATGTGGGAAATAGCAACACGGGGAATGACTCCCTATCCTGG
AGTCCAGAACCATGAGATGTACGATTACCTTCTCCACGGCCACAGGCTGAAGCAGCCCGAGGAC
TGCCTGGATGATCTGTATGAAATCATGTACTCTTGCTGGAGTGCTGATCCCCTGGACCGACCCA
CCTTCTCAGTGCTGAGGCTGCAGCTGGAAAAGCTCTCCGAGAGTTTGCCTGATGCCCAGGACAA
AGAATCCATCATCTACATCAATACACAGTTACTAGAGAGCTGCGAGGGCCTAGCCAACAGGTCC
TCCCTCGCAGGGCTAGACATGAACATTGATCCTGACTCCATCATTGCCTCTTGCACAGCAGGTG
CTGCTGTCAGCGTGGTCATGGCGGAAGTTCACGAGAACAACCTTCATGAGGAAAGATACATCTT
AAATGGGGGCAACGAGGAATGGGAAGATGTGGCCTCCACTCCATTTGCTACAGTCACAGCTGGA
AAAGATGGTGTGTTACCAGAGGACAGACTCACCAAAAATGGCATCTCCTGGTCTCACCATAGTA
CGCTACCCTTGGGGAGCCCATCACCAGATGAACTTCTGTTTGCAGACGACTCCTCGGGAGACTC
TGAAGTTCTGATGTGA

hide sequence

Protein Sequences


Protein RefSeqs	NP_075232	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAF44060	(Get FASTA)	NCBI Sequence Viewer
	AAF44061	(Get FASTA)	NCBI Sequence Viewer
	APO36716	(Get FASTA)	NCBI Sequence Viewer
	EDL80138	(Get FASTA)	NCBI Sequence Viewer
	EDL80139	(Get FASTA)	NCBI Sequence Viewer
	P57097	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_075232 ⟸ NM_022943
- Peptide Label:	precursor
- UniProtKB:	P57097 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MVLAPLLLGLLLLSALWNGGTAEKEEEIKPDQPFSGPLPGSLPADHRPFFAPHSSGDQLSPSQT GRSHPAHTATPQMTSAASNLLPPVAFKNTIGRIVLSEHKSVKFNCSINIPNVYQETAGISWWKD GKELLGAHHSITQFYPDEEGVSIIALFSITSVQRSDNGSYICKMKVNDREVVSDPIYVEVQGLP YFTKQPESVNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNENPERSPSVLTVAGLTETAVFS CEAHNDKGLTVSKGVQINIKVIPSPPTEVHILNSTAHSILVSWVPGFDGYSPLQNCSIQVKEAD QLSNGSVMVFNTSASPHLYEVQQLQALANYSVTVSCRNEIGWSAVSPWILASTTEGAPAVAPLN ITVFLNESSNNLEIRWTKPPIKRQDGELVGYRISHVWESAGTSKELSEEVSQNGSWAQVPVQMH NATCTVRIAVITKGGIGPFSEPVDVAIPEHSRVDYAPSSTPAPGNTESMLIILGCFCGFVLMGL ILYLSLAIKRRVQETKFGGAFSEEDSQLVVNYRAKKSFCRRAIELTLQSLGVSEELQNKLEDVV VDRNLLILGKVLGEGEFGSVMEGNLKQEDGTSQKVAVKTMKLDNFSLREIEEFLSEAACMKDFN HPNVIRLLGVCIELSSQGIPKPMVILPFMKYGDLHTFLLYSRIESVPKSIPLQTLLKFMVDIAQ GMEYLSSRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLA DRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDDLYEIMYSCW SADPLDRPTFSVLRLQLEKLSESLPDAQDKESIIYINTQLLESCEGLANRSSLAGLDMNIDPDS IIASCTAGAAVSVVMAEVHENNLHEERYILNGGNEEWEDVASTPFATVTAGKDGVLPEDRLTKN GISWSHHSTLPLGSPSPDELLFADDSSGDSEVLM hide sequence

RefSeq Acc Id:

ENSRNOP00000023419 ⟸ ENSRNOT00000023419

Protein Domains

Fibronectin type-III Ig-like C2-type Protein kinase

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692414

Promoter ID:

EPDNEW_R2939

Type:

multiple initiation site

Name:

Mertk_1

Description:

MER proto-oncogene, tyrosine kinase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	121,235,112 - 121,235,172	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:69283	AgrOrtholog
Ensembl Genes	ENSRNOG00000017319	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSRNOP00000023419	ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000023419	ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH	2.60.40.10	UniProtKB/Swiss-Prot
InterPro	FN3_dom	UniProtKB/Swiss-Prot
	FN3_sf	UniProtKB/Swiss-Prot
	Ig-like_dom	UniProtKB/Swiss-Prot
	Ig-like_dom_sf	UniProtKB/Swiss-Prot
	Ig-like_fold	UniProtKB/Swiss-Prot
	Ig_sub	UniProtKB/Swiss-Prot
	Immunoglobulin	UniProtKB/Swiss-Prot
	Kinase-like_dom_sf	UniProtKB/Swiss-Prot
	Prot_kinase_dom	UniProtKB/Swiss-Prot
	Protein_kinase_ATP_BS	UniProtKB/Swiss-Prot
	Ser-Thr/Tyr_kinase_cat_dom	UniProtKB/Swiss-Prot
	Tyr_kinase_AS	UniProtKB/Swiss-Prot
	Tyr_kinase_cat_dom	UniProtKB/Swiss-Prot
KEGG Report	rno:65037	UniProtKB/Swiss-Prot
NCBI Gene	65037	ENTREZGENE
Pfam	fn3	UniProtKB/Swiss-Prot
	Ig_2	UniProtKB/Swiss-Prot
	PF00047	UniProtKB/Swiss-Prot
	Pkinase_Tyr	UniProtKB/Swiss-Prot
PhenoGen	Mertk	PhenoGen
PRINTS	TYRKINASE	UniProtKB/Swiss-Prot
PROSITE	FN3	UniProtKB/Swiss-Prot
	IG_LIKE	UniProtKB/Swiss-Prot
	PROTEIN_KINASE_ATP	UniProtKB/Swiss-Prot
	PROTEIN_KINASE_DOM	UniProtKB/Swiss-Prot
	PROTEIN_KINASE_TYR	UniProtKB/Swiss-Prot
SMART	FN3	UniProtKB/Swiss-Prot
	SM00409	UniProtKB/Swiss-Prot
	TyrKc	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF48726	UniProtKB/Swiss-Prot
	SSF49265	UniProtKB/Swiss-Prot
	SSF56112	UniProtKB/Swiss-Prot
UniProt	A0A1L5L8Q5_RAT	UniProtKB/TrEMBL
	MERTK_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q9JL63_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-07-10	Mertk	MER proto-oncogene, tyrosine kinase	Mertk	c-mer proto-oncogene tyrosine kinase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-06-06	Mertk	c-mer proto-oncogene tyrosine kinase	Rdy	retinal dystrophy	Data Merged	737654	APPROVED
2003-04-09	Rdy	retinal dystrophy		Retinal dystrophy	Name updated	629478	APPROVED
2002-06-10	Rdy	Retinal dystrophy			Symbol and Name status set to approved	70586	APPROVED
2002-06-10	Mertk	c-mer proto-oncogene tyrosine kinase			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_disease	mutation causes the retinal dystrophy (rdy) phenotype in the Royal College of Surgeons (RCS) rat	69668
gene_disease	mutation causes the retinal dystrophy (rdy) phenotype in the Royal College of Surgeons (RCS) rat	1299193
gene_function	tyrosine kinase receptor	61793
gene_function	tyrosine kinase receptor	69668
gene_mutations_overexpression	gene transfer corrects a defect in retinal pigment epithelium (RPE) phagocytosis in the retinal dystrophy (rdy) locus of the Royal College of Surgeons (RCS) rat by restoring normal phagocytosis of shed photoreceptor outer segments	69668
gene_mutations_overexpression	gene transfer to the eyes of young Royal College of Surgeons (RCS) rats with (rdy) retinal dystrophy increases sensitivity to low intensity light	69668
gene_process	required for proper retina functioning	61793
gene_process	required for proper retina functioning	69668
gene_process	involved as a signaling molecule triggering outer segment uptake during phagocytosis	1299193
gene_product	member of the axl family	61793
gene_product	member of the axl family	69668
gene_protein	994 amino acids	61793
gene_protein	994 amino acids	69668

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM