Mertk (MER proto-oncogene, tyrosine kinase) - Rat Genome Database

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Gene: Mertk (MER proto-oncogene, tyrosine kinase) Heterocephalus glaber
Analyze
Symbol: Mertk
Name: MER proto-oncogene, tyrosine kinase
RGD ID: 18905527
Description: ENCODES a protein that exhibits ATP binding (inferred); protein tyrosine kinase activity (inferred); transmembrane receptor protein tyrosine kinase activity (inferred); INVOLVED IN apoptotic cell clearance (ortholog); establishment of localization in cell (ortholog); lymphocyte activation (ortholog); ASSOCIATED WITH carcinoma (ortholog); COVID-19 (ortholog); fundus dystrophy (ortholog); FOUND IN cytoplasm (ortholog); extracellular space (ortholog); photoreceptor outer segment (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: c-mer proto-oncogene tyrosine kinase; Proto-oncogene tyrosine-protein kinase MER; tyrosine-protein kinase Mer
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624749341,289 - 443,640 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624749337,441 - 444,730 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Mertk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624749341,289 - 443,640 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624749337,441 - 444,730 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
MERTK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382111,898,607 - 112,029,561 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2111,898,607 - 112,029,561 (+)EnsemblGRCh38hg38GRCh38
GRCh372112,656,184 - 112,787,138 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362112,372,662 - 112,503,416 (+)NCBINCBI36Build 36hg18NCBI36
Build 342112,372,415 - 112,503,168NCBI
Celera2106,258,379 - 106,389,184 (-)NCBICelera
Cytogenetic Map2q13NCBI
HuRef2105,169,541 - 105,300,438 (+)NCBIHuRef
CHM1_12112,661,190 - 112,791,926 (+)NCBICHM1_1
T2T-CHM13v2.02112,325,012 - 112,456,507 (+)NCBIT2T-CHM13v2.0
Mertk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392128,540,836 - 128,645,082 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2128,540,876 - 128,644,814 (+)EnsemblGRCm39 Ensembl
GRCm382128,698,915 - 128,803,162 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2128,698,956 - 128,802,894 (+)EnsemblGRCm38mm10GRCm38
MGSCv372128,524,733 - 128,627,923 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362128,390,438 - 128,493,628 (+)NCBIMGSCv36mm8
Celera2129,929,620 - 130,029,340 (+)NCBICelera
Cytogenetic Map2F1NCBI
cM Map262.63NCBI
Mertk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83136,391,936 - 136,498,366 (+)NCBIGRCr8
mRatBN7.23115,939,351 - 116,045,141 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3115,939,351 - 116,046,554 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3119,836,222 - 119,942,080 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03128,431,776 - 128,537,642 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03126,092,272 - 126,198,124 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03121,235,230 - 121,340,932 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3121,235,119 - 121,342,444 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03128,669,534 - 128,777,078 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43116,308,387 - 116,416,414 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13116,213,959 - 116,321,987 (+)NCBI
Celera3114,768,654 - 114,872,632 (+)NCBICelera
Cytogenetic Map3q36NCBI
Mertk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554702,065,411 - 2,167,909 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554702,065,468 - 2,167,909 (-)NCBIChiLan1.0ChiLan1.0
MERTK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21216,046,414 - 16,179,196 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A16,049,177 - 16,181,960 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A89,977,226 - 90,109,970 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A113,055,554 - 113,162,556 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A113,056,852 - 113,162,052 (+)Ensemblpanpan1.1panPan2
MERTK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11736,336,787 - 36,445,796 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1736,336,861 - 36,445,380 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1736,106,597 - 36,218,038 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01737,111,333 - 37,223,997 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1737,111,394 - 37,223,995 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11736,231,212 - 36,343,496 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01736,303,304 - 36,415,155 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01736,515,620 - 36,628,095 (+)NCBIUU_Cfam_GSD_1.0
Mertk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629281,712,891 - 81,810,395 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936783607,382 - 704,889 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936783607,425 - 704,879 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MERTK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl344,349,385 - 44,483,402 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1344,349,377 - 44,483,400 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2345,947,411 - 45,961,016 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MERTK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11414,971,858 - 15,100,736 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1415,001,471 - 15,101,025 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660804,589,380 - 4,720,259 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000007190   ⟹   ENSHGLP00000007105
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624749341,289 - 443,640 (-)Ensembl
RefSeq Acc Id: XM_004844311   ⟹   XP_004844368
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624749340,639 - 443,666 (-)NCBI
RefSeq Acc Id: XM_004844312   ⟹   XP_004844369
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624749340,639 - 443,391 (-)NCBI
RefSeq Acc Id: XM_004844314   ⟹   XP_004844371
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624749340,639 - 442,956 (-)NCBI
RefSeq Acc Id: XM_004844315   ⟹   XP_004844372
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624749340,639 - 433,178 (-)NCBI
RefSeq Acc Id: XM_021257966   ⟹   XP_021113625
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624749340,639 - 444,729 (-)NCBI
RefSeq Acc Id: XM_021257967   ⟹   XP_021113626
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624749337,441 - 444,730 (-)NCBI
RefSeq Acc Id: XM_021257968   ⟹   XP_021113627
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624749340,639 - 443,216 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_021113626   ⟸   XM_021257967
- Peptide Label: isoform X2
RefSeq Acc Id: XP_021113625   ⟸   XM_021257966
- Peptide Label: isoform X1
RefSeq Acc Id: XP_004844368   ⟸   XM_004844311
- Peptide Label: isoform X3
- UniProtKB: A0A0P6J3I5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004844369   ⟸   XM_004844312
- Peptide Label: isoform X5
RefSeq Acc Id: XP_021113627   ⟸   XM_021257968
- Peptide Label: isoform X4
- UniProtKB: G5BQY7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004844371   ⟸   XM_004844314
- Peptide Label: isoform X4
- UniProtKB: G5BQY7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004844372   ⟸   XM_004844315
- Peptide Label: isoform X4
- UniProtKB: G5BQY7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000007105   ⟸   ENSHGLT00000007190


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000005187 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000007190 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Immunoglobulin UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
KEGG Report hgl:101718876 UniProtKB/TrEMBL
NCBI Gene Mertk ENTREZGENE
PANTHER TYROSINE-PROTEIN KINASE MER UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/TrEMBL
Pfam fn3 UniProtKB/TrEMBL
  Ig_3 UniProtKB/TrEMBL
  PF00047 UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/TrEMBL
  IG_LIKE UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
SMART FN3 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
  SSF49265 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A0P6J3I5 ENTREZGENE, UniProtKB/TrEMBL
  G5BQY7 ENTREZGENE, UniProtKB/TrEMBL