St14 (ST14 transmembrane serine protease matriptase)

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Gene: St14 (ST14 transmembrane serine protease matriptase) Rattus norvegicus

Analyze

Symbol:

St14

Name:

ST14 transmembrane serine protease matriptase

RGD ID:

69288

Description:

Exhibits serine-type peptidase activity. Involved in proteolysis. Localizes to basolateral plasma membrane; extracellular space; and extrinsic component of plasma membrane. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 11. Orthologous to human ST14 (ST14 transmembrane serine protease matriptase); INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

matriptase; membrane-type serine protease; MT-SP1; suppression of tumorigenicity 14; suppression of tumorigenicity 14 (colon carcinoma matriptase epithin); suppression of tumorigenicity 14 (colon carcinoma); suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin)

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	8	29,540,805 - 29,581,704 (-)	NCBI
Rnor_6.0 Ensembl	8	32,240,133 - 32,280,869 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	8	32,240,113 - 32,280,813 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	8	32,266,158 - 32,305,925 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	30,916,769 - 30,932,214 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	8	30,925,535 - 30,940,977 (-)	NCBI
Celera	8	31,002,596 - 31,042,887 (-)	NCBI		Celera
Cytogenetic Map	8	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal recessive congenital ichthyosis 11 (ISO)

Breast Neoplasms (ISO)

COVID-19 (ISO)

ductal carcinoma in situ (ISO)

Dwarfism (ISO)

dysgerminoma (ISO)

Endometrial Neoplasms (ISO)

Endometrioid Carcinomas (ISO)

Experimental Liver Cirrhosis (ISO)

granulosa cell tumor (ISO)

High Myopia (ISO)

idiopathic pulmonary fibrosis (ISO)

Jacobsen Syndrome (ISO)

Lymphatic Metastasis (ISO)

Neoplasm Metastasis (ISO)

Netherton syndrome (ISO)

Ovarian Neoplasms (ISO)

prostate carcinoma in situ (ISO)

Prostatic Neoplasms (ISO)

renal cell carcinoma (ISO)

schizophrenia (ISO)

Sjogren's syndrome (ISS)

Uterine Cervical Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane (EXP,ISO)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

3-chloropropane-1,2-diol (EXP)

4,4'-diaminodiphenylmethane (EXP)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrylamide (EXP)

aflatoxin B1 (ISO)

aflatoxin B2 (ISO)

all-trans-retinoic acid (ISO)

amphetamine (EXP)

antirheumatic drug (ISO)

benzalkonium chloride (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bleomycin A2 (ISO)

butan-1-ol (ISO)

calcitriol (ISO)

choline (ISO)

cisplatin (ISO)

cyclophosphamide (ISO)

dibutyl phthalate (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

ethanol (ISO)

folic acid (ISO)

folpet (ISO)

fonofos (ISO)

furan (EXP)

hypochlorous acid (ISO)

indole-3-methanol (EXP)

isobutanol (ISO)

L-methionine (ISO)

leflunomide (ISO)

menadione (ISO)

mercury dibromide (ISO)

mitomycin C (ISO)

N-methyl-4-phenylpyridinium (EXP)

N-nitrosodimethylamine (EXP)

nickel atom (ISO)

panobinostat (ISO)

parathion (ISO)

parathion-methyl (EXP)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

progesterone (ISO)

propiconazole (ISO)

SB 431542 (ISO)

selenium atom (ISO)

silicon dioxide (ISO)

sodium dichromate (ISO)

terbufos (ISO)

Tesaglitazar (EXP)

thioacetamide (EXP)

titanium dioxide (ISO)

tributylstannane (ISO)

trichostatin A (ISO)

troglitazone (EXP)

urethane (ISO)

valproic acid (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

epithelial cell morphogenesis involved in placental branching (ISO)

keratinocyte differentiation (IBA,ISO)

neural tube closure (ISO)

proteolysis (IDA,ISO)

Cellular Component

basolateral plasma membrane (IDA)

extracellular region (ISO)

extracellular space (IDA)

extrinsic component of plasma membrane (IDA,ISO)

integral component of membrane (IEA)

Molecular Function

serine-type endopeptidase activity (ISO)

serine-type peptidase activity (IDA,ISO)

References

References - curated


1.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA data from the GO Consortium
3.	Jin JS, etal., Histol Histopathol. 2007 Mar;22(3):305-9.
4.	Jin JS, etal., Int J Surg Pathol. 2006 Jan;14(1):65-72.
5.	Jin JS, etal., Mod Pathol. 2006 Mar;19(3):447-52.
6.	Lee JW, etal., Hum Pathol. 2005 Jun;36(6):626-33.
7.	MGD data from the GO Consortium
8.	Nakamura K, etal., Anticancer Res. 2009 May;29(5):1685-90.
9.	NCBI rat LocusLink and RefSeq merged data July 26, 2002
10.	OMIM Disease Annotation Pipeline
11.	RGD automated data pipeline
12.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13.	RGD automated import pipeline for gene-chemical interactions
14.	Satomi S, etal., Biochem Biophys Res Commun 2001 Oct 5;287(4):995-1002.
15.	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
16.	Tsuzuki S, etal., Biochem J. 2005 Jun 1;388(Pt 2):679-87.
17.	Warren M, etal., Appl Immunohistochem Mol Morphol. 2009 Jan;17(1):23-30.
18.	Welm AL, etal., Proc Natl Acad Sci U S A. 2007 May 1;104(18):7570-5. Epub 2007 Apr 24.

Additional References at PubMed

PMID:11567025	PMID:12477932	PMID:18843291	PMID:19202271	PMID:19592578	PMID:19800422	PMID:19897900	PMID:19911255	PMID:20657595	PMID:20682770	PMID:23038671	PMID:23376485

Genomics

Comparative Map Data

St14
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	8	29,540,805 - 29,581,704 (-)	NCBI
Rnor_6.0 Ensembl	8	32,240,133 - 32,280,869 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	8	32,240,113 - 32,280,813 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	8	32,266,158 - 32,305,925 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	30,916,769 - 30,932,214 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	8	30,925,535 - 30,940,977 (-)	NCBI
Celera	8	31,002,596 - 31,042,887 (-)	NCBI		Celera
Cytogenetic Map	8	q13	NCBI

ST14
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	11	130,159,782 - 130,210,362 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	11	130,159,782 - 130,210,362 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	11	130,029,677 - 130,080,257 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
GRCh37	11	130,029,682 - 130,080,257 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	129,534,892 - 129,585,467 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	11	129,534,932 - 129,585,466	NCBI
Celera	11	127,197,379 - 127,248,136 (+)	NCBI
Cytogenetic Map	11	q24.3	NCBI
HuRef	11	125,980,949 - 126,032,941 (+)	NCBI		HuRef
CHM1_1	11	129,915,529 - 129,966,064 (+)	NCBI		CHM1_1

St14
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	30,999,886 - 31,043,138 (-)	NCBI	GRCm39		mm39
GRCm38	9	31,088,590 - 31,131,811 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	31,089,402 - 31,131,853 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	30,896,175 - 30,939,384 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	9	30,838,155 - 30,881,364 (-)	NCBI			mm8
Celera	9	28,347,788 - 28,391,153 (-)	NCBI		Celera
Cytogenetic Map	9	A4	NCBI
cM Map	9	16.61	NCBI

St14
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955412	31,090,504 - 31,129,050 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955412	31,091,313 - 31,129,050 (+)	NCBI	ChiLan1.0	ChiLan1.0

ST14
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	11	128,890,780 - 128,913,559 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	128,888,124 - 128,913,559 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	11	125,001,771 - 125,021,371 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

ST14
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	5	4,651,863 - 4,691,069 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	5	4,652,493 - 4,666,728 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

St14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936572	2,137,820 - 2,182,674 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ST14
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	56,888,246 - 56,929,771 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	56,888,246 - 56,929,771 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	63,158,988 - 63,198,157 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ST14
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	121,238,666 - 121,290,528 (+)	NCBI
ChlSab1.1 Ensembl	1	121,238,643 - 121,290,007 (+)	Ensembl

St14
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624812	4,584,043 - 4,620,410 (+)	NCBI

Position Markers

D8Arb5

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	8	32,272,273 - 32,272,467	NCBI	Rnor6.0
Rnor_5.0	8	32,297,385 - 32,297,579	UniSTS	Rnor5.0
Celera	8	31,034,337 - 31,034,541	UniSTS
RH 3.4 Map	8	215.0	RGD
RH 3.4 Map	8	215.0	UniSTS
RH 2.0 Map	8	177.7	RGD
SHRSP x BN Map	8	21.12	RGD
FHH x ACI Map	8	22.03	RGD
Cytogenetic Map	8	q13	UniSTS

AW530531

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	8	32,248,231 - 32,248,438	NCBI	Rnor6.0
Rnor_5.0	8	32,274,276 - 32,274,483	UniSTS	Rnor5.0
RGSC_v3.4	8	30,924,887 - 30,925,094	UniSTS	RGSC3.4
Celera	8	31,010,711 - 31,010,918	UniSTS
RH 3.4 Map	8	250.3	UniSTS
Cytogenetic Map	8	q13	UniSTS

RH138338

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	8	32,270,631 - 32,270,829	NCBI	Rnor6.0
Rnor_5.0	8	32,295,743 - 32,295,941	UniSTS	Rnor5.0
Celera	8	31,032,695 - 31,032,893	UniSTS
RH 3.4 Map	8	254.7	UniSTS
Cytogenetic Map	8	q13	UniSTS

RH141540

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	8	32,240,197 - 32,240,390	NCBI	Rnor6.0
Rnor_5.0	8	32,266,242 - 32,266,435	UniSTS	Rnor5.0
RGSC_v3.4	8	30,916,853 - 30,917,046	UniSTS	RGSC3.4
Celera	8	31,002,680 - 31,002,873	UniSTS
Cytogenetic Map	8	q13	UniSTS

St14

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	8	32,243,466 - 32,244,170	NCBI	Rnor6.0
Rnor_5.0	8	32,269,511 - 32,270,215	UniSTS	Rnor5.0
Celera	8	31,005,949 - 31,006,653	UniSTS
Cytogenetic Map	8	q13	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
12880023	Bw184	Body weight QTL 184		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	8	2108128	47108128	Rat
12880025	Cm102	Cardiac mass QTL 102		0.044	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	8	2108128	47108128	Rat
12880028	Cm103	Cardiac mass QTL 103		0.02	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	8	2108128	47108128	Rat
12880044	Am9	Aortic mass QTL 9		0.007	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	8	2108128	47108128	Rat
2317032	Ginf2	Gastrointestinal inflammation QTL 2	3.21	0.005	liver integrity trait (VT:0010547)	liver granuloma severity score (CMO:0002157)	8	7368076	52368076	Rat
2317036	Livw3	Liver weight QTL 3	2.43	0.01	liver mass (VT:0003402)	liver weight to body weight ratio (CMO:0000633)	8	7368076	52368076	Rat
2317048	Ginf1	Gastrointestinal inflammation QTL 1	3.52	0.005	cecum mucosa thickness (VT:0010234)	enterocolitis severity score (CMO:0002138)	8	7368076	52368076	Rat
2301416	Bp315	Blood pressure QTL 315		0.008	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	8738677	53738677	Rat
1581557	Eae16	Experimental allergic encephalomyelitis QTL 16	3.8		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	8	9531047	119211942	Rat
1354627	Despr14	Despair related QTL 14		0.0056	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	8	10388439	55388439	Rat
1354595	Despr4	Despair related QTL 4	2.16	0.0036	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	8	10388439	55388439	Rat
631650	Stl6	Serum triglyceride level QTL 6	4	0.0019	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	10938911	120496129	Rat
1598824	Memor4	Memory QTL 4	2.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	8	11373267	57541668	Rat
1357398	Slep3	Serum leptin concentration QTL 3	3.43		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	8	11373509	45712344	Rat
2302367	Slep5	Serum leptin concentration QTL 5	3.43		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	8	11373509	45712344	Rat
2317030	Wbc5	White blood cell count QTL 5	3.21	0.005	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	8	11448251	56448251	Rat
2317051	Aia18	Adjuvant induced arthritis QTL 18	2.42		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	8	11448251	56448251	Rat
1558646	Swd5	Spike wave discharge measurement QTL 5	3.45	0.00036	brain electrophysiology trait (VT:0010557)	brain spike-and-wave discharge frequency (CMO:0001742)	8	17666555	62666555	Rat
61373	Mcs4	Mammary carcinoma susceptibility QTL 4	1.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	8	20717592	65717592	Rat
631271	Lecl1	Lens clarity QTL 1		0.001	lens clarity trait (VT:0001304)	age of onset/diagnosis of cataract (CMO:0001584)	8	21464919	91140553	Rat
731182	Uae24	Urinary albumin excretion QTL 24	6.4		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	21813070	100873963	Rat
631842	Inf1	Infertility severity QTL 1	4.1	0.001	seminal gland mass (VT:0010524)	seminal vesicle wet weight (CMO:0001603)	8	27841496	72841496	Rat
1359021	Bp271	Blood pressure QTL 271	1.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	28168023	50708951	Rat
631648	Stl5	Serum triglyceride level QTL 5	4	0.0003	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	29867983	59908353	Rat
1358892	Kidm26	Kidney mass QTL 26	3.69		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	29867983	106526740	Rat
1358896	Bp262	Blood pressure QTL 262	2.89		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	29867983	106526740	Rat
1358907	Cm40	Cardiac mass QTL 40	1.89		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	29867983	106526740	Rat
2303564	Gluco43	Glucose level QTL 43	3		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	8	30144800	75144800	Rat
2303572	Insul13	Insulin level QTL 13	2		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	8	30144800	75144800	Rat
724540	Uae8	Urinary albumin excretion QTL 8	5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	8	30845450	33558764	Rat
1331804	Cm30	Cardiac mass QTL 30	3.77443		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	8	30918112	58858224	Rat
1300146	Rf17	Renal function QTL 17	2.9		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	8	30918112	75918112	Rat
8662823	Vetf5	Vascular elastic tissue fragility QTL 5	1.9		artery integrity trait (VT:0010639)	patent ductus arteriosus score (CMO:0002566)	8	30918112	107206309	Rat
2302278	Gluco36	Glucose level QTL 36	4.2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	8	32201981	54065241	Rat
724514	Uae15	Urinary albumin excretion QTL 15	2.9		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	32201981	75971421	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	269
Count of miRNA genes:	191
Interacting mature miRNAs:	209
Transcripts:	ENSRNOT00000009139
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3								4	35	16	11
Low		36	55	41	19	41	2	5	69		25		2
Below cutoff		7	2				6	6	1				6

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053635	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039080660	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB037898	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB049189	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC128347	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC097271	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000190	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000009139 ⟹ ENSRNOP00000009139

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	8	32,240,133 - 32,280,869 (-)	Ensembl

RefSeq Acc Id:

NM_053635 ⟹ NP_446087

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	29,540,810 - 29,581,517 (-)	NCBI
Rnor_6.0	8	32,240,113 - 32,280,813 (-)	NCBI
Rnor_5.0	8	32,266,158 - 32,305,925 (-)	NCBI
RGSC_v3.4	8	30,916,769 - 30,932,214 (-)	RGD
Celera	8	31,002,596 - 31,042,887 (-)	RGD

Sequence:

show sequence

CCGGGACTGGGCTCGTGCCTCCCCTCACACCCTTCGTTCCTCGTGTCCCCAGCACCCCGCGGGT
CATGGTAGTCGGTTGCCGGCAGAGACCACGCGTCTGAGACCGGCGATCGGGCCGCCGAGACCAT
GGGGAACAATCGGGGCCGCAAGGCCGGAGGGGGCTCGCAGGACTTCGGCGCCGGACTCAAGTAC
AACTCCCGGCTAGAGAACATGAATGGCTTTGAGGAGGGTGTGGAGTTCCTGCCTGTGAACAACG
CCAAGCAGGTGGAGAAGCGAGGCCCCAGGCGCTGGGTGGTGATGGTGGCCGTAGTGTTCAGCTT
CCTTTTGCTCTCGCTCATGGCCGGCTTGCTGGTGTGGCACTTCCATTACCGGAATGTGAGGATC
CAAAAGGTCTTCAATGGCCATCTGAGGATCACGAATGAGAACTTTCTGGACGCGTATGAGAACT
CCACCTCCACGGAGTTCATCAGCCTGGCCAGTCAGGTGAAGGAAGCGCTGAAGCTGATGTACAG
TGAAGTCCCTGTCCTGGGCCCCTACCACAAGAAATCGACTGTAACTGCCTTCAGTGAGGGCAGC
GTCATTGCCTACTACTGGTCAGAGTTCAGCATCCCCCCACACCTGGAGGAAGAGGTTGATCGCG
CCATGGCTGTGGAGCGAGTTGTCACACTGCCACCCCGAGCACGGGCACTGAAATCCTTCGTGCT
GACCTCTGTGGTGGCCTTCCCCATTGACCCCAGAATGCTCCAGAGGACTCAGGACAACAGCTGC
AGTTTTGCCCTCCATGCCCGTGGCAGGACAGTGACACGTTTCACTACCCCTGGCTTCCCTAACA
GTCCCTACCCAGCTCATGCCCGCTGCCAGTGGGTCCTGCGGGGGGACGCGGACTCTGTGCTGAG
CCTCACCTTCCGAAGTTTTGATGTCGCGCCCTGTGATGGGCATGACAGTGACCTGGTCACAGTG
TATGACAGCCTGAGCCCCATGGAGCCCCATGCTGTGGTGCGGCTGTGTGGCACCTTCTCGCCCT
CCTACAACCTGACTTTCCTCTCCTCCCAGAACGTCTTCCTTGTTACGCTGATAACCAACACTGA
CCGGCGACATCCTGGCTTTGAGGCCACTTTCTTCCAGCTGCCCAAGATGAGCAGCTGTGGCGGC
CTTTTGAGTGAAGCCCAAGGGACGTTTAGCAGCCCCTACTATCCAGGCCATTACCCGCCCAACA
TCAACTGCACATGGAATATCAAGGTGCCCAACAACCGGAACGTGAAAGTACGCTTCAAACTCTT
CTATCTGGTGGACCCCAACATACCAGTGGGAAGCTGCACCAAGGACTATGTGGAGATCAACGGG
GAGAAGTTCTGCGGTGAGAGGTCCCAGTTTGTGGTGAGCAGCAACAGCAGCAAGATTACGGTCC
ACTTCCATTCTGATCACTCGTACACGGACACCGGGTTCCTGGCTGAGTATCTCTCCTACGACTC
CAATGACCCATGCCCAGGGATGTTCATGTGTAAGACTGGACGGTGCATCCGCAAGGACTTGCGC
TGCGATGGCTGGGCTGACTGCCCGGACTACAGTGATGAGCGTCACTGCCGATGCAACGCTACCC
ACCAGTTCATGTGCAAGAACCAGTTCTGCAAGCCCCTCTTCTGGGTCTGTGACAGTGTCAACGA
CTGTGGGGATGGCAGCGATGAGGAGGGCTGCAGTTGTCCTGCCGGGAGTTTCAAGTGTTCCAAT
GGGAAGTGTCTCCCTCAGAGCCAGCAGTGTAATGGGAAGGACGACTGTGGAGATGGGTCTGACG
AGGCCTCATGTGACAATGTGAATGCCGTCTCTTGCACCAAATATACCTACCGCTGCCAAAATGG
CCTCTGTCTGAACAAGGGCAACCCTGAGTGTGATGGGAAGAAGGACTGCAGCGATGGCTCGGAT
GAGAAAAACTGTGACTGTGGGCTGCGATCCTTTACCAAACAGGCTCGAGTGGTTGGTGGCACGA
ATGCGGACGAGGGCGAGTGGCCCTGGCAGGTGAGCCTCCACGCTCTGGGCCAGGGCCACTTGTG
TGGGGCCTCGCTCATCTCTCCTGACTGGCTGGTCTCTGCAGCTCATTGCTTTCAGGATGAGACA
ATTTTCAAGTACTCAGACCACACCATGTGGACAGCCTTCCTCGGTCTGCTGGACCAGAGCAAGC
GCAGTGCCTCTGGGGTACAGGAGCACAAGCTCAAACGTATCATCACTCACCCTTCCTTTAATGA
CTTTACCTTCGACTATGACATTGCCTTGCTGGAGCTGGAGAAGCCGGCAGAGTACAGCACTGTC
GTGCGCCCCATCTGCCTGCCTGATAATACCCATGTCTTTCCTGCCGGCAAAGCCATCTGGGTCA
CAGGCTGGGGCCACACGAAAGAAGGAGGAACTGGAGCACTGATCCTGCAGAAGGGAGAGATCCG
GGTCATCAACCAGACCACCTGTGAGGAACTCTTGCCGCAGCAGATCACCCCACGAATGATGTGT
GTGGGTTTCCTCAGTGGGGGTGTGGACTCCTGCCAGGGTGATTCCGGTGGCCCCTTGTCCAGTG
TGGAGAAAGATGGGCGAATCTTCCAGGCTGGTGTGGTGAGCTGGGGTGAAGGCTGCGCTCAGAG
GAACAAGCCAGGCGTGTACACAAGGATCCCTGAAGTTCGGGACTGGATCAAAGAGCAAACTGGG
GTATAGAAGCATGGACAGACAACCCACCATGAACTCGCAAAGGGATGCCCCCCACGCGTACCTG
GATACAGCAGAGGATCGCTGAGGACATTTGTGCTGTGGCCTCTCCCCCACATCCCAGACTGTGA
ACTGCTTCCCTAGGACTCAGAATCCTTCCCTGAGCTTCCAAAGTGGGACCCCTCAGGAGTTGGC
CAGAGATCTTCTGTGCTGGTGGCCCAGCCCGGGGTGGGGCAAGGATTTGATGGCAGCCTTCCCC
TCTAACCCTGAACTGGGTAAAGACGATGCTTTCCTGGAGAACTGCTTCCAGACTCTAAAGGAAA
ACTATCGTCGCGCTCCTGGGGGCCCTATGGGCAGAGGGGCTGCAGGGTCTTTCAGGAAGCTCCA
GCCCTAGGGACCCCAGAAAAGAGTGGCACCTATGGCTGAGTTTGTTTTGCTGGTATTTGAGAGT
AAAACATTTTATTTCTTTTTAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039080660 ⟹ XP_038936588

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	29,540,805 - 29,581,704 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_446087	(Get FASTA)	NCBI Sequence Viewer
	XP_038936588	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH97271	(Get FASTA)	NCBI Sequence Viewer
	BAB03502	(Get FASTA)	NCBI Sequence Viewer
	BAB13765	(Get FASTA)	NCBI Sequence Viewer
	EDL83315	(Get FASTA)	NCBI Sequence Viewer
	EDL83316	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_446087 ⟸ NM_053635

- UniProtKB:

Q9JJI7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGNNRGRKAGGGSQDFGAGLKYNSRLENMNGFEEGVEFLPVNNAKQVEKRGPRRWVVMVAVVFS
FLLLSLMAGLLVWHFHYRNVRIQKVFNGHLRITNENFLDAYENSTSTEFISLASQVKEALKLMY
SEVPVLGPYHKKSTVTAFSEGSVIAYYWSEFSIPPHLEEEVDRAMAVERVVTLPPRARALKSFV
LTSVVAFPIDPRMLQRTQDNSCSFALHARGRTVTRFTTPGFPNSPYPAHARCQWVLRGDADSVL
SLTFRSFDVAPCDGHDSDLVTVYDSLSPMEPHAVVRLCGTFSPSYNLTFLSSQNVFLVTLITNT
DRRHPGFEATFFQLPKMSSCGGLLSEAQGTFSSPYYPGHYPPNINCTWNIKVPNNRNVKVRFKL
FYLVDPNIPVGSCTKDYVEINGEKFCGERSQFVVSSNSSKITVHFHSDHSYTDTGFLAEYLSYD
SNDPCPGMFMCKTGRCIRKDLRCDGWADCPDYSDERHCRCNATHQFMCKNQFCKPLFWVCDSVN
DCGDGSDEEGCSCPAGSFKCSNGKCLPQSQQCNGKDDCGDGSDEASCDNVNAVSCTKYTYRCQN
GLCLNKGNPECDGKKDCSDGSDEKNCDCGLRSFTKQARVVGGTNADEGEWPWQVSLHALGQGHL
CGASLISPDWLVSAAHCFQDETIFKYSDHTMWTAFLGLLDQSKRSASGVQEHKLKRIITHPSFN
DFTFDYDIALLELEKPAEYSTVVRPICLPDNTHVFPAGKAIWVTGWGHTKEGGTGALILQKGEI
RVINQTTCEELLPQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVEKDGRIFQAGVVSWGEGCAQ
RNKPGVYTRIPEVRDWIKEQTGV

hide sequence

RefSeq Acc Id:

ENSRNOP00000009139 ⟸ ENSRNOT00000009139

RefSeq Acc Id:	XP_038936588 ⟸ XM_039080660
- Peptide Label:	isoform X1

Protein Domains

CUB Peptidase S1 SEA

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695824

Promoter ID:

EPDNEW_R6349

Type:

initiation region

Name:

St14_1

Description:

suppression of tumorigenicity 14

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	32,280,848 - 32,280,908	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:69288	AgrOrtholog
Ensembl Genes	ENSRNOG00000005903	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000009139	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000009139	ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH	2.40.10.10	UniProtKB/TrEMBL
	2.60.120.290	UniProtKB/TrEMBL
	3.30.70.960	UniProtKB/TrEMBL
	4.10.400.10	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7445508	IMAGE-MGC_LOAD
InterPro	CUB	UniProtKB/TrEMBL
	LDL_receptor-like_sf	UniProtKB/TrEMBL
	LDLR_class-A_CS	UniProtKB/TrEMBL
	LDrepeatLR_classA_rpt	UniProtKB/TrEMBL
	Pept_cys/ser_Trypsin-like	UniProtKB/TrEMBL
	Peptidase_S1/S6_AS	UniProtKB/TrEMBL
	Peptidase_S1_PA_chymotrypsin	UniProtKB/TrEMBL
	Peptidase_S1_S6	UniProtKB/TrEMBL
	Peptidase_S1A_matripase	UniProtKB/TrEMBL
	SEA	UniProtKB/TrEMBL
	SEA_dom_sf	UniProtKB/TrEMBL
	sperma_CUB_dom	UniProtKB/TrEMBL
	TRYPSIN_SER	UniProtKB/TrEMBL
KEGG Report	rno:114093	UniProtKB/TrEMBL
MGC_CLONE	MGC:114245	IMAGE-MGC_LOAD
NCBI Gene	114093	ENTREZGENE
Pfam	CUB	UniProtKB/TrEMBL
	Ldl_recept_a	UniProtKB/TrEMBL
	SEA	UniProtKB/TrEMBL
	Trypsin	UniProtKB/TrEMBL
PhenoGen	St14	PhenoGen
PIRSF	ST14	UniProtKB/TrEMBL
PRINTS	LDLRECEPTOR	UniProtKB/TrEMBL
PROSITE	CUB	UniProtKB/TrEMBL
	LDLRA_1	UniProtKB/TrEMBL
	LDLRA_2	UniProtKB/TrEMBL
	SEA	UniProtKB/TrEMBL
	TRYPSIN_DOM	UniProtKB/TrEMBL
	TRYPSIN_HIS	UniProtKB/TrEMBL
	TRYPSIN_SER	UniProtKB/TrEMBL
SMART	CUB	UniProtKB/TrEMBL
	LDLa	UniProtKB/TrEMBL
	Tryp_SPc	UniProtKB/TrEMBL
Superfamily-SCOP	CUB	UniProtKB/TrEMBL
	LDL_rcpt_classA_cys-rich	UniProtKB/TrEMBL
	Pept_Ser_Cys	UniProtKB/TrEMBL
	SSF82671	UniProtKB/TrEMBL
TIGR	TC207836
UniProt	Q9JJI7	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	F1LRR7	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2020-06-22	St14	ST14 transmembrane serine protease matriptase	St14	suppression of tumorigenicity 14	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2015-11-25	St14	suppression of tumorigenicity 14	St14	suppression of tumorigenicity 14 (colon carcinoma)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	St14	suppression of tumorigenicity 14 (colon carcinoma)		suppression of tumorigenicity 14	Name updated	1299863	APPROVED
2002-06-10	St14	suppression of tumorigenicity 14			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	mRNA expressed in the loosely attached cells of the basement membrane of the epithelial layer of the small intestinal upper villi and the colon	634217
gene_process	helps in the digestion of fibronectin and laminin	634217

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM