Kmo (kynurenine 3-monooxygenase) - Rat Genome Database

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Gene: Kmo (kynurenine 3-monooxygenase) Rattus norvegicus
Analyze
Symbol: Kmo
Name: kynurenine 3-monooxygenase
RGD ID: 620610
Description: Enables kynurenine 3-monooxygenase activity. Involved in several processes, including carboxylic acid metabolic process; cellular response to interleukin-1; and positive regulation of glutamate secretion, neurotransmission. Located in extracellular space and mitochondrial outer membrane. Used to study schizophrenia. Biomarker of mental depression. Orthologous to human KMO (kynurenine 3-monooxygenase); PARTICIPATES IN tryptophan metabolic pathway; kynurenine metabolic pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: kynurenine 3-hydroxylase; kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21387,557,080 - 87,589,334 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1387,557,286 - 87,588,881 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1390,057,159 - 90,088,772 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01391,457,419 - 91,489,032 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01388,636,585 - 88,668,179 (+)NCBIRnor_WKY
Rnor_6.01393,684,324 - 93,715,378 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1393,684,437 - 93,716,227 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01398,149,340 - 98,180,255 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41391,363,517 - 91,394,174 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11391,552,400 - 91,583,055 (+)NCBI
Celera1387,155,915 - 87,185,730 (+)NCBICelera
Cytogenetic Map13q25NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-hydroxykynurenine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
5-methoxytryptamine  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bosentan  (ISO)
buta-1,3-diene  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
dexamethasone  (ISO)
dimethoate  (EXP)
dimethylarsinic acid  (ISO)
endosulfan  (EXP)
fipronil  (EXP)
flutamide  (EXP)
GW 4064  (ISO)
indometacin  (ISO)
kynurenic acid  (EXP)
kynurenine  (EXP)
Lasiocarpine  (ISO)
lidocaine  (EXP)
methylarsonic acid  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Muraglitazar  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nimesulide  (EXP)
nitrofen  (EXP)
nitroglycerin  (EXP)
O-methyleugenol  (ISO)
orphenadrine  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
PhIP  (EXP)
pirinixic acid  (EXP,ISO)
propiconazole  (ISO)
Ro 61-8048  (EXP)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
Tesaglitazar  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cloning and functional expression of human kynurenine 3-monooxygenase. Alberati-Giani D, etal., FEBS Lett 1997 Jun 30;410(2-3):407-12.
2. Presence of kynurenine hydroxylase in developing rat brain. Battie C and Verity MA, J Neurochem. 1981 Mar;36(3):1308-10.
3. Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase. Breton J, etal., Eur J Biochem. 2000 Feb;267(4):1092-9.
4. Kynurenine 3-mono-oxygenase inhibitors attenuate post-ischemic neuronal death in organotypic hippocampal slice cultures. Carpenedo R, etal., J Neurochem. 2002 Sep;82(6):1465-71.
5. The effect of age on the enzyme activities of tryptophan metabolism along the kynurenine pathway in rats. Comai S, etal., Clin Chim Acta. 2005 Oct;360(1-2):67-80. doi: 10.1016/j.cccn.2005.04.013.
6. Induction of indolamine 2,3-dioxygenase and kynurenine 3-monooxygenase in rat brain following a systemic inflammatory challenge: a role for IFN-gamma? Connor TJ, etal., Neurosci Lett. 2008 Aug 15;441(1):29-34. doi: 10.1016/j.neulet.2008.06.007. Epub 2008 Jun 7.
7. A radiometric assay for kynurenine 3-hydroxylase based on the release of 3H2O during hydroxylation of L-[3,5-3H]kynurenine. Erickson JB, etal., Anal Biochem. 1992 Sep;205(2):257-62.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. New insight into the antidepressants action: modulation of kynurenine pathway by increasing the kynurenic acid/3-hydroxykynurenine ratio. Kocki T, etal., J Neural Transm (Vienna). 2012 Feb;119(2):235-43. doi: 10.1007/s00702-011-0668-8. Epub 2011 Jun 10.
11. Quinolinic acid metabolism in the rat brain. Immunohistochemical identification of 3-hydroxyanthranilic acid oxygenase and quinolinic acid phosphoribosyltransferase in the hippocampal region. Kohler C, etal., J Neurosci. 1988 Mar;8(3):975-87.
12. Expression of the kynurenine pathway enzymes in the pancreatic islet cells. Activation by cytokines and glucolipotoxicity. Liu JJ, etal., Biochim Biophys Acta. 2015 May;1852(5):980-91. doi: 10.1016/j.bbadis.2015.02.001. Epub 2015 Feb 9.
13. The kynurenine pathway and neurodegenerative disease. Maddison DC and Giorgini F, Semin Cell Dev Biol. 2015 Apr;40:134-41. doi: 10.1016/j.semcdb.2015.03.002. Epub 2015 Mar 12.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis. Mole DJ, etal., Nat Med. 2016 Feb;22(2):202-9. doi: 10.1038/nm.4020. Epub 2016 Jan 11.
16. Kynurenine 3-mono-oxygenase inhibitors reduce glutamate concentration in the extracellular spaces of the basal ganglia but not in those of the cortex or hippocampus. Moroni F, etal., Neuropharmacology. 2005 May;48(6):788-95. doi: 10.1016/j.neuropharm.2004.10.019.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Enzymatic studies on tryptophan metabolism disorder in rats chronically exposed to carbon disulfide. Okayama A, etal., Toxicol Appl Pharmacol. 1988 Jul;94(3):356-61.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Pharmacological kynurenine 3-monooxygenase enzyme inhibition significantly reduces neuropathic pain in a rat model. Rojewska E, etal., Neuropharmacology. 2016 Mar;102:80-91. doi: 10.1016/j.neuropharm.2015.10.040. Epub 2015 Oct 31.
25. The inhibition of the kynurenine pathway prevents behavioral disturbances and oxidative stress in the brain of adult rats subjected to an animal model of schizophrenia. RĂ©us GZ, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2018 Feb 2;81:55-63. doi: 10.1016/j.pnpbp.2017.10.009. Epub 2017 Oct 13.
26. Impaired kynurenine pathway metabolism in the prefrontal cortex of individuals with schizophrenia. Sathyasaikumar KV, etal., Schizophr Bull. 2011 Nov;37(6):1147-56. doi: 10.1093/schbul/sbq112. Epub 2010 Oct 29.
27. Effect of branched chain alpha-keto acids on kynurenine 3-hydroxylase from rat liver. Shin M, etal., J Nutr Sci Vitaminol (Tokyo). 1982;28(3):203-7.
28. Kynurenine-3-monooxygenase: a review of structure, mechanism, and inhibitors. Smith JR, etal., Drug Discov Today. 2016 Feb;21(2):315-24. doi: 10.1016/j.drudis.2015.11.001. Epub 2015 Nov 14.
29. Kynurenine metabolism in vitamin-B-6-deficient rat liver after tryptophan injection. Takeuchi F and Shibata Y, Biochem J. 1984 Jun 15;220(3):693-9.
30. Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis. Walker AL, etal., J Med Chem. 2017 Apr 27;60(8):3383-3404. doi: 10.1021/acs.jmedchem.7b00055. Epub 2017 Apr 11.
31. Regulation of the kynurenine metabolism pathway by Xiaoyao San and the underlying effect in the hippocampus of the depressed rat. Wang J, etal., J Ethnopharmacol. 2018 Mar 25;214:13-21. doi: 10.1016/j.jep.2017.11.037. Epub 2017 Dec 5.
32. Development of LC/MS/MS, high-throughput enzymatic and cellular assays for the characterization of compounds that inhibit kynurenine monooxygenase (KMO). Winkler D, etal., J Biomol Screen. 2013 Sep;18(8):879-89. doi: 10.1177/1087057113489731. Epub 2013 May 20.
Additional References at PubMed
PMID:12402501   PMID:12477932   PMID:12865426   PMID:14651853   PMID:15489334   PMID:23376485   PMID:23575632   PMID:29208702   PMID:29429898  


Genomics

Comparative Map Data
Kmo
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21387,557,080 - 87,589,334 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1387,557,286 - 87,588,881 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1390,057,159 - 90,088,772 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01391,457,419 - 91,489,032 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01388,636,585 - 88,668,179 (+)NCBIRnor_WKY
Rnor_6.01393,684,324 - 93,715,378 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1393,684,437 - 93,716,227 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01398,149,340 - 98,180,255 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41391,363,517 - 91,394,174 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11391,552,400 - 91,583,055 (+)NCBI
Celera1387,155,915 - 87,185,730 (+)NCBICelera
Cytogenetic Map13q25NCBI
KMO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381241,532,378 - 241,595,642 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1241,532,134 - 241,595,642 (+)EnsemblGRCh38hg38GRCh38
GRCh371241,695,678 - 241,758,944 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361239,762,330 - 239,825,566 (+)NCBINCBI36Build 36hg18NCBI36
Build 341238,021,747 - 238,084,984NCBI
Celera1214,950,683 - 215,013,947 (+)NCBICelera
Cytogenetic Map1q43NCBI
HuRef1212,153,669 - 212,217,265 (+)NCBIHuRef
CHM1_11242,968,145 - 243,031,623 (+)NCBICHM1_1
T2T-CHM13v2.01240,943,769 - 241,007,043 (+)NCBIT2T-CHM13v2.0
Kmo
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391175,459,759 - 175,488,419 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1175,447,947 - 175,489,682 (+)EnsemblGRCm39 Ensembl
GRCm381175,632,193 - 175,660,853 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1175,620,381 - 175,662,116 (+)EnsemblGRCm38mm10GRCm38
MGSCv371177,562,324 - 177,590,984 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361177,468,868 - 177,497,528 (+)NCBIMGSCv36mm8
Celera1182,717,886 - 182,746,514 (+)NCBICelera
Cytogenetic Map1H3NCBI
Kmo
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540610,493,379 - 10,527,201 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540610,496,102 - 10,527,181 (-)NCBIChiLan1.0ChiLan1.0
KMO
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11222,075,577 - 222,138,866 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1222,075,268 - 222,138,866 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01217,094,037 - 217,157,827 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
KMO
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1732,941,487 - 32,994,541 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl732,941,487 - 32,994,541 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha732,419,026 - 32,472,013 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0732,767,900 - 32,821,021 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl732,767,900 - 32,821,021 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1732,602,997 - 32,656,010 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0732,627,134 - 32,680,135 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0732,875,278 - 32,928,138 (+)NCBIUU_Cfam_GSD_1.0
Kmo
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934445,818,797 - 45,870,212 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365268,877,434 - 8,919,548 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365268,877,085 - 8,928,280 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KMO
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1012,434,769 - 12,490,409 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11012,442,877 - 12,489,417 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21014,879,142 - 14,937,353 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KMO
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12578,611,194 - 78,670,314 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2578,628,757 - 78,670,181 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605580,745,055 - 80,803,000 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kmo
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477111,899,624 - 11,942,806 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477111,900,020 - 11,942,943 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kmo
118 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:230
Count of miRNA genes:150
Interacting mature miRNAs:180
Transcripts:ENSRNOT00000005005
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat

Markers in Region
RH133932  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21387,586,985 - 87,587,170 (+)MAPPERmRatBN7.2
Rnor_6.01393,714,134 - 93,714,318NCBIRnor6.0
Rnor_5.01398,178,493 - 98,178,677UniSTSRnor5.0
RGSC_v3.41391,393,964 - 91,394,148UniSTSRGSC3.4
Celera1387,185,520 - 87,185,704UniSTS
RH 3.4 Map13588.3UniSTS
Cytogenetic Map13q25UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 37 37 11 37 23
Low 1 4 20 4 8 4 4 4 25 8 23 11 4
Below cutoff 33 4 7 45 4 17 4

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_021593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005492281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC119639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF056031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC088142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000005005   ⟹   ENSRNOP00000005005
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1387,557,286 - 87,588,881 (+)Ensembl
Rnor_6.0 Ensembl1393,684,437 - 93,716,227 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100456   ⟹   ENSRNOP00000095165
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1387,557,286 - 87,588,881 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000114438   ⟹   ENSRNOP00000097495
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1387,562,627 - 87,588,881 (+)Ensembl
RefSeq Acc Id: NM_021593   ⟹   NP_067604
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21387,557,286 - 87,588,881 (+)NCBI
Rnor_6.01393,684,499 - 93,714,344 (+)NCBI
Rnor_5.01398,149,340 - 98,180,255 (+)NCBI
RGSC_v3.41391,363,517 - 91,394,174 (+)RGD
Celera1387,155,915 - 87,185,730 (+)RGD
Sequence:
RefSeq Acc Id: XM_006250325   ⟹   XP_006250387
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21387,557,080 - 87,588,284 (+)NCBI
Rnor_6.01393,684,326 - 93,715,378 (+)NCBI
Rnor_5.01398,149,340 - 98,180,255 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006250327   ⟹   XP_006250389
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21387,557,286 - 87,588,284 (+)NCBI
Rnor_6.01393,684,324 - 93,715,378 (+)NCBI
Rnor_5.01398,149,340 - 98,180,255 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008769795   ⟹   XP_008768017
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21387,574,160 - 87,588,284 (+)NCBI
Rnor_6.01393,702,100 - 93,715,378 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039091044   ⟹   XP_038946972
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21387,557,324 - 87,589,334 (+)NCBI
RefSeq Acc Id: XM_039091045   ⟹   XP_038946973
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21387,557,387 - 87,588,284 (+)NCBI
RefSeq Acc Id: XM_039091046   ⟹   XP_038946974
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21387,557,324 - 87,583,128 (+)NCBI
RefSeq Acc Id: XM_039091047   ⟹   XP_038946975
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21387,575,721 - 87,588,284 (+)NCBI
RefSeq Acc Id: XR_005492281
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21387,557,324 - 87,585,148 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_067604   ⟸   NM_021593
- UniProtKB: O88867 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006250389   ⟸   XM_006250327
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006250387   ⟸   XM_006250325
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008768017   ⟸   XM_008769795
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSRNOP00000005005   ⟸   ENSRNOT00000005005
RefSeq Acc Id: XP_038946972   ⟸   XM_039091044
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038946974   ⟸   XM_039091046
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038946973   ⟸   XM_039091045
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038946975   ⟸   XM_039091047
- Peptide Label: isoform X6
RefSeq Acc Id: ENSRNOP00000095165   ⟸   ENSRNOT00000100456
RefSeq Acc Id: ENSRNOP00000097495   ⟸   ENSRNOT00000114438
Protein Domains
FAD-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88867-F1-model_v2 AlphaFold O88867 1-478 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699041
Promoter ID:EPDNEW_R9565
Type:initiation region
Name:Kmo_1
Description:kynurenine 3-monooxygenase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01393,684,491 - 93,684,551EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620610 AgrOrtholog
BioCyc Gene G2FUF-17232 BioCyc
BioCyc Pathway PWY-5651 [L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde] BioCyc
Ensembl Genes ENSRNOG00000003709 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000005005 ENTREZGENE
  ENSRNOP00000005005.3 UniProtKB/Swiss-Prot
  ENSRNOP00000095165.1 UniProtKB/TrEMBL
  ENSRNOP00000097495.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005005 ENTREZGENE
  ENSRNOT00000005005.7 UniProtKB/Swiss-Prot
  ENSRNOT00000100456.1 UniProtKB/TrEMBL
  ENSRNOT00000114438.1 UniProtKB/TrEMBL
Gene3D-CATH 3.50.50.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7322842 IMAGE-MGC_LOAD
InterPro FAD-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD/NAD-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kynurenine_monooxygenase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:59113 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108700 IMAGE-MGC_LOAD
NCBI Gene 59113 ENTREZGENE
PANTHER KYNURENINE 3-MONOOXYGENASE UniProtKB/Swiss-Prot
  KYNURENINE 3-MONOOXYGENASE UniProtKB/Swiss-Prot
  KYNURENINE 3-MONOOXYGENASE UniProtKB/TrEMBL
  KYNURENINE 3-MONOOXYGENASE UniProtKB/TrEMBL
Pfam FAD_binding_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kmo PhenoGen
PRINTS RNGMNOXGNASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51905 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AJ51_RAT UniProtKB/TrEMBL
  A0A8I6AUG8_RAT UniProtKB/TrEMBL
  KMO_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-25 Kmo  kynurenine 3-monooxygenase  Kmo  kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Kmo  kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)    kynurenine 3-hydroxylase  Name updated 1299863 APPROVED
2002-08-07 Kmo  kynurenine 3-hydroxylase      Symbol and Name status set to provisional 70820 PROVISIONAL