Kmo (kynurenine 3-monooxygenase) - Rat Genome Database

Name: Kmo
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Kmo (kynurenine 3-monooxygenase) Rattus norvegicus

Analyze

Symbol:

Kmo

Name:

kynurenine 3-monooxygenase

RGD ID:

620610

Description:

Enables kynurenine 3-monooxygenase activity. Involved in several processes, including carboxylic acid metabolic process; cellular response to interleukin-1; and positive regulation of glutamate secretion, neurotransmission. Located in extracellular space and mitochondrial outer membrane. Used to study schizophrenia. Biomarker of mental depression. Orthologous to human KMO (kynurenine 3-monooxygenase); PARTICIPATES IN tryptophan metabolic pathway; kynurenine metabolic pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

kynurenine 3-hydroxylase; kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	KMO (kynurenine 3-monooxygenase)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Kmo (kynurenine 3-monooxygenase (kynurenine 3-hydroxylase))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Kmo (kynurenine 3-monooxygenase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	KMO (kynurenine 3-monooxygenase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	KMO (kynurenine 3-monooxygenase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Kmo (kynurenine 3-monooxygenase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	KMO (kynurenine 3-monooxygenase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	KMO (kynurenine 3-monooxygenase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Kmo (kynurenine 3-monooxygenase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Kmo (kynurenine 3-monooxygenase (kynurenine 3-hydroxylase))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	KMO (kynurenine 3-monooxygenase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	kmo (kynurenine 3-monooxygenase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	BNA4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	cn	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	kmo-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	kmo-2	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	13	87,557,080 - 87,589,334 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	87,557,286 - 87,588,881 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	90,057,159 - 90,088,772 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	13	91,457,419 - 91,489,032 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	13	88,636,585 - 88,668,179 (+)	NCBI	Rnor_WKY
Rnor_6.0	13	93,684,324 - 93,715,378 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	93,684,437 - 93,716,227 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	98,149,340 - 98,180,255 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	91,363,517 - 91,394,174 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	91,552,400 - 91,583,055 (+)	NCBI
Celera	13	87,155,915 - 87,185,730 (+)	NCBI		Celera
Cytogenetic Map	13	q25	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute Experimental Pancreatitis (IMP,ISO)

allergic contact dermatitis (ISO)

Experimental Liver Cirrhosis (ISO)

fumarase deficiency (ISO)

gastrointestinal stromal tumor (ISO)

genetic disease (ISO)

Hereditary Leiomyomatosis and Renal Cell Cancer (ISO)

Hyperalgesia (IMP)

Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 2 (ISO)

mental depression (IEP)

Neurodevelopmental Disorders (ISO)

parathyroid carcinoma (ISO)

schizophrenia (IMP,ISO)

Spinal Cord Injuries (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (EXP)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3-chloropropane-1,2-diol (EXP)

3-hydroxykynurenine (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-diaminodiphenylmethane (EXP)

5-methoxytryptamine (EXP)

acetamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

antirheumatic drug (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP,ISO)

bosentan (ISO)

buta-1,3-diene (ISO)

calcitriol (ISO)

carbon nanotube (ISO)

chlorpyrifos (ISO)

copper atom (EXP)

copper(0) (EXP)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

cytarabine (ISO)

dexamethasone (ISO)

dimethoate (EXP)

dimethylarsinic acid (ISO)

endosulfan (EXP)

fipronil (EXP)

flutamide (EXP)

GW 4064 (ISO)

indometacin (ISO)

kynurenic acid (EXP)

kynurenine (EXP)

Lasiocarpine (ISO)

lidocaine (EXP)

methylarsonic acid (ISO)

mono(2-ethylhexyl) phthalate (ISO)

Muraglitazar (EXP)

N-nitrosodiethylamine (EXP)

N-nitrosodimethylamine (EXP)

N-Nitrosopyrrolidine (ISO)

nickel atom (ISO)

nimesulide (EXP)

nitrofen (EXP)

nitroglycerin (EXP)

O-methyleugenol (ISO)

orphenadrine (EXP)

ozone (ISO)

paracetamol (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorononanoic acid (ISO)

perfluorooctanoic acid (EXP)

phenobarbital (ISO)

PhIP (EXP)

pirinixic acid (EXP,ISO)

propiconazole (ISO)

Ro 61-8048 (EXP)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

Tesaglitazar (EXP)

testosterone (EXP)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

valproic acid (ISO)

vancomycin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

'de novo' NAD biosynthetic process from tryptophan (IEA)

aging (IEP)

anthranilate metabolic process (IEA)

cellular response to interleukin-1 (IEP)

cellular response to lipopolysaccharide (IEP)

kynurenic acid biosynthetic process (IMP)

kynurenine metabolic process (IBA,IDA,ISO)

L-kynurenine metabolic process (IDA)

NAD metabolic process (IDA,ISO)

positive regulation of glutamate secretion (IMP)

positive regulation of glutamate secretion, neurotransmission (IMP)

positive regulation of neuron death (IMP)

quinolinate biosynthetic process (IEA)

response to lipopolysaccharide (IEP)

response to salt stress (ISO)

tryptophan catabolic process (IEA)

Cellular Component

extracellular space (IDA)

membrane (IEA)

mitochondrial outer membrane (IBA,IDA,IEA)

mitochondrion (IDA)

Molecular Function

FAD binding (IEA,ISO,ISS)

flavin adenine dinucleotide binding (ISO)

kynurenine 3-monooxygenase activity (IBA,IDA,IEA,ISO)

monooxygenase activity (IEA)

NAD(P)H oxidase H2O2-forming activity (ISO,ISS)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

kynurenine metabolic pathway (ISO)

tryptophan metabolic pathway (IDA,IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Cloning and functional expression of human kynurenine 3-monooxygenase.	Alberati-Giani D, etal., FEBS Lett 1997 Jun 30;410(2-3):407-12.
2.	Presence of kynurenine hydroxylase in developing rat brain.	Battie C and Verity MA, J Neurochem. 1981 Mar;36(3):1308-10.
3.	Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase.	Breton J, etal., Eur J Biochem. 2000 Feb;267(4):1092-9.
4.	Kynurenine 3-mono-oxygenase inhibitors attenuate post-ischemic neuronal death in organotypic hippocampal slice cultures.	Carpenedo R, etal., J Neurochem. 2002 Sep;82(6):1465-71.
5.	The effect of age on the enzyme activities of tryptophan metabolism along the kynurenine pathway in rats.	Comai S, etal., Clin Chim Acta. 2005 Oct;360(1-2):67-80. doi: 10.1016/j.cccn.2005.04.013.
6.	Induction of indolamine 2,3-dioxygenase and kynurenine 3-monooxygenase in rat brain following a systemic inflammatory challenge: a role for IFN-gamma?	Connor TJ, etal., Neurosci Lett. 2008 Aug 15;441(1):29-34. doi: 10.1016/j.neulet.2008.06.007. Epub 2008 Jun 7.
7.	A radiometric assay for kynurenine 3-hydroxylase based on the release of 3H2O during hydroxylation of L-[3,5-3H]kynurenine.	Erickson JB, etal., Anal Biochem. 1992 Sep;205(2):257-62.
8.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
10.	New insight into the antidepressants action: modulation of kynurenine pathway by increasing the kynurenic acid/3-hydroxykynurenine ratio.	Kocki T, etal., J Neural Transm (Vienna). 2012 Feb;119(2):235-43. doi: 10.1007/s00702-011-0668-8. Epub 2011 Jun 10.
11.	Quinolinic acid metabolism in the rat brain. Immunohistochemical identification of 3-hydroxyanthranilic acid oxygenase and quinolinic acid phosphoribosyltransferase in the hippocampal region.	Kohler C, etal., J Neurosci. 1988 Mar;8(3):975-87.
12.	Expression of the kynurenine pathway enzymes in the pancreatic islet cells. Activation by cytokines and glucolipotoxicity.	Liu JJ, etal., Biochim Biophys Acta. 2015 May;1852(5):980-91. doi: 10.1016/j.bbadis.2015.02.001. Epub 2015 Feb 9.
13.	The kynurenine pathway and neurodegenerative disease.	Maddison DC and Giorgini F, Semin Cell Dev Biol. 2015 Apr;40:134-41. doi: 10.1016/j.semcdb.2015.03.002. Epub 2015 Mar 12.
14.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
15.	Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis.	Mole DJ, etal., Nat Med. 2016 Feb;22(2):202-9. doi: 10.1038/nm.4020. Epub 2016 Jan 11.
16.	Kynurenine 3-mono-oxygenase inhibitors reduce glutamate concentration in the extracellular spaces of the basal ganglia but not in those of the cortex or hippocampus.	Moroni F, etal., Neuropharmacology. 2005 May;48(6):788-95. doi: 10.1016/j.neuropharm.2004.10.019.
17.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
18.	Enzymatic studies on tryptophan metabolism disorder in rats chronically exposed to carbon disulfide.	Okayama A, etal., Toxicol Appl Pharmacol. 1988 Jul;94(3):356-61.
19.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
20.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
21.	GOA pipeline	RGD automated data pipeline
22.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
24.	Pharmacological kynurenine 3-monooxygenase enzyme inhibition significantly reduces neuropathic pain in a rat model.	Rojewska E, etal., Neuropharmacology. 2016 Mar;102:80-91. doi: 10.1016/j.neuropharm.2015.10.040. Epub 2015 Oct 31.
25.	The inhibition of the kynurenine pathway prevents behavioral disturbances and oxidative stress in the brain of adult rats subjected to an animal model of schizophrenia.	Réus GZ, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2018 Feb 2;81:55-63. doi: 10.1016/j.pnpbp.2017.10.009. Epub 2017 Oct 13.
26.	Impaired kynurenine pathway metabolism in the prefrontal cortex of individuals with schizophrenia.	Sathyasaikumar KV, etal., Schizophr Bull. 2011 Nov;37(6):1147-56. doi: 10.1093/schbul/sbq112. Epub 2010 Oct 29.
27.	Effect of branched chain alpha-keto acids on kynurenine 3-hydroxylase from rat liver.	Shin M, etal., J Nutr Sci Vitaminol (Tokyo). 1982;28(3):203-7.
28.	Kynurenine-3-monooxygenase: a review of structure, mechanism, and inhibitors.	Smith JR, etal., Drug Discov Today. 2016 Feb;21(2):315-24. doi: 10.1016/j.drudis.2015.11.001. Epub 2015 Nov 14.
29.	Kynurenine metabolism in vitamin-B-6-deficient rat liver after tryptophan injection.	Takeuchi F and Shibata Y, Biochem J. 1984 Jun 15;220(3):693-9.
30.	Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis.	Walker AL, etal., J Med Chem. 2017 Apr 27;60(8):3383-3404. doi: 10.1021/acs.jmedchem.7b00055. Epub 2017 Apr 11.
31.	Regulation of the kynurenine metabolism pathway by Xiaoyao San and the underlying effect in the hippocampus of the depressed rat.	Wang J, etal., J Ethnopharmacol. 2018 Mar 25;214:13-21. doi: 10.1016/j.jep.2017.11.037. Epub 2017 Dec 5.
32.	Development of LC/MS/MS, high-throughput enzymatic and cellular assays for the characterization of compounds that inhibit kynurenine monooxygenase (KMO).	Winkler D, etal., J Biomol Screen. 2013 Sep;18(8):879-89. doi: 10.1177/1087057113489731. Epub 2013 May 20.

Additional References at PubMed

PMID:12402501	PMID:12477932	PMID:12865426	PMID:14651853	PMID:15489334	PMID:23376485	PMID:23575632	PMID:29208702	PMID:29429898

Genomics

Comparative Map Data

Kmo
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	13	87,557,080 - 87,589,334 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	87,557,286 - 87,588,881 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	90,057,159 - 90,088,772 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	13	91,457,419 - 91,489,032 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	13	88,636,585 - 88,668,179 (+)	NCBI	Rnor_WKY
Rnor_6.0	13	93,684,324 - 93,715,378 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	93,684,437 - 93,716,227 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	98,149,340 - 98,180,255 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	91,363,517 - 91,394,174 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	91,552,400 - 91,583,055 (+)	NCBI
Celera	13	87,155,915 - 87,185,730 (+)	NCBI		Celera
Cytogenetic Map	13	q25	NCBI

KMO
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	241,532,378 - 241,595,642 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	1	241,532,134 - 241,595,642 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	241,695,678 - 241,758,944 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	239,762,330 - 239,825,566 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	238,021,747 - 238,084,984	NCBI
Celera	1	214,950,683 - 215,013,947 (+)	NCBI		Celera
Cytogenetic Map	1	q43	NCBI
HuRef	1	212,153,669 - 212,217,265 (+)	NCBI		HuRef
CHM1_1	1	242,968,145 - 243,031,623 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	240,943,769 - 241,007,043 (+)	NCBI		T2T-CHM13v2.0

Kmo
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	175,459,759 - 175,488,419 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	175,447,947 - 175,489,682 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	175,632,193 - 175,660,853 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	175,620,381 - 175,662,116 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	177,562,324 - 177,590,984 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	177,468,868 - 177,497,528 (+)	NCBI		MGSCv36	mm8
Celera	1	182,717,886 - 182,746,514 (+)	NCBI		Celera
Cytogenetic Map	1	H3	NCBI

Kmo
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955406	10,493,379 - 10,527,201 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955406	10,496,102 - 10,527,181 (-)	NCBI	ChiLan1.0	ChiLan1.0

KMO
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	1	222,075,577 - 222,138,866 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	222,075,268 - 222,138,866 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	1	217,094,037 - 217,157,827 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

KMO
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	32,941,487 - 32,994,541 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	32,941,487 - 32,994,541 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	32,419,026 - 32,472,013 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	32,767,900 - 32,821,021 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	32,767,900 - 32,821,021 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	32,602,997 - 32,656,010 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	32,627,134 - 32,680,135 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	32,875,278 - 32,928,138 (+)	NCBI		UU_Cfam_GSD_1.0

Kmo
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	45,818,797 - 45,870,212 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936526	8,877,434 - 8,919,548 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936526	8,877,085 - 8,928,280 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

KMO
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	12,434,769 - 12,490,409 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	10	12,442,877 - 12,489,417 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	14,879,142 - 14,937,353 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

KMO
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	78,611,194 - 78,670,314 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	78,628,757 - 78,670,181 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666055	80,745,055 - 80,803,000 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Kmo
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624771	11,899,624 - 11,942,806 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624771	11,900,020 - 11,942,943 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Kmo
118 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	230
Count of miRNA genes:	150
Interacting mature miRNAs:	180
Transcripts:	ENSRNOT00000005005
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	1	101056920	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	1	101056920	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	101056920	Rat
1581570	Eae17	Experimental allergic encephalomyelitis QTL 17	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	13	8897350	101631289	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	20605871	101339738	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	30395351	101056920	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	31241331	93395974	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	31241331	93395974	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	31241331	93395974	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	13	31241331	93395974	Rat
12879444	Bp397	Blood pressure QTL 397			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	45049404	90049404	Rat
12879471	Bp398	Blood pressure QTL 398			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	45514719	90514719	Rat
12879441	Bp396	Blood pressure QTL 396			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	45699983	90699983	Rat
1298066	Bp159	Blood pressure QTL 159		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	46088046	91088046	Rat
1641901	Alcrsp6	Alcohol response QTL 6			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	13	52362171	97362171	Rat
1354655	Bp241	Blood pressure QTL 241	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	56056920	101056920	Rat
12879475	Bp400	Blood pressure QTL 400			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	61825626	106807694	Rat
2293702	Bss34	Bone structure and strength QTL 34	4.61	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	13	65103704	106807694	Rat
2293687	Bss26	Bone structure and strength QTL 26	4.6	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	13	65103704	106807694	Rat
8655959	Pur32	Proteinuria QTL 32	8.4		urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	74023918	97213863	Rat
2293341	Glom15	Glomerulus QTL 15	9.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	13	74862117	101339893	Rat
4889606	Gluco63	Glucose level QTL 63	2.86	0.003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	13	80753256	106807694	Rat

Markers in Region

RH133932

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	87,586,985 - 87,587,170 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	93,714,134 - 93,714,318	NCBI	Rnor6.0
Rnor_5.0	13	98,178,493 - 98,178,677	UniSTS	Rnor5.0
RGSC_v3.4	13	91,393,964 - 91,394,148	UniSTS	RGSC3.4
Celera	13	87,185,520 - 87,185,704	UniSTS
RH 3.4 Map	13	588.3	UniSTS
Cytogenetic Map	13	q25	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2		37	37	11	37				23
Low	1	4	20	4	8	4	4	4	25	8	23	11	4
Below cutoff		33					4	7	45	4	17		4

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_021593	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006250325	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006250327	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008769794	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008769795	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039091044	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039091045	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039091046	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039091047	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005492281	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC119639	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF056031	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC088142	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473985	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ210049	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000245	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000005005 ⟹ ENSRNOP00000005005

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	87,557,286 - 87,588,881 (+)	Ensembl
Rnor_6.0 Ensembl	13	93,684,437 - 93,716,227 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000100456 ⟹ ENSRNOP00000095165

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	87,557,286 - 87,588,881 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000114438 ⟹ ENSRNOP00000097495

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	87,562,627 - 87,588,881 (+)	Ensembl

RefSeq Acc Id:

NM_021593 ⟹ NP_067604

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	87,557,286 - 87,588,881 (+)	NCBI
Rnor_6.0	13	93,684,499 - 93,714,344 (+)	NCBI
Rnor_5.0	13	98,149,340 - 98,180,255 (+)	NCBI
RGSC_v3.4	13	91,363,517 - 91,394,174 (+)	RGD
Celera	13	87,155,915 - 87,185,730 (+)	RGD

Sequence:

show sequence

CCACGCGTCCGAGCTCCTACCTGAGCAGAGGTATTCTGGCAGCAATGGCATCGTCGGACACTGA
AGGAAAAAGAGTGGTTGTTATCGGTGGTGGTTTGGTTGGAGCATTGAACGCGTGCTTTCTCGCA
AAGAGGAATTTCCAAGTTGATGTGTACGAAGCTAGGGAAGATATTCGAGTGGCTAACTTTATGC
GTGGAAGAAGCATTAATTTGGCCCTTTCTTATAGAGGACGGCAGGCCTTGAAGGCCGTTGGTCT
GGAAGATCAGATCGTGTCCAAAGGTGTGCCCATGAAAGCCAGAATGATCCACTCTCTCTCGGGA
AAGAAGTCTGCAATTCCCTATGGGAACAAGTCACAGTATATCCTTTCAATAAGCAGAGAAAAGT
TAAACAAGGATCTGCTGACTGCCGTGGAGTCCTACCCCAATGCAAAGGTGCACTTTGGCCACAA
GCTGTCAAAATGCTGTCCGGAGGAAGGGATACTCACGATGCTTGGACCCAACAAAGTTCCCAGA
GACATCACGTGTGACCTCATTGTAGGATGTGATGGGGCCTACTCAACTGTCAGAGCTCACCTCA
TGAAGAAGCCCCGTTTTGATTACAGTCAGCAATATATCCCTCATGGCTATATGGAGCTGACAAT
TCCACCTAAGAACGGGGAGTATGCCATGGAACCTAACTGTCTTCACATTTGGCCTAGAAATGCC
TTTATGATGATCGCCCTACCGAACATGGACAAATCTTTCACATGCACCTTGTTCATGTCCTTTG
AGGAGTTTGAAAAGCTTCCAACGCATAGTGATGTGCTGGACTTCTTCCAGAAGAACTTTCCAGA
TGCCATCCCTCTGATGGGCGAGCAAGCCCTCATGAGAGATTTCTTTCTGTTGCCTGCCCAGCCC
ATGATATCAGTAAAGTGCTCTCCCTTCCACCTGAAGTCACGCTGTGTGCTGATGGGAGATGCAG
CTCATGCCATCGTCCCATTTTTTGGGCAAGGAATGAATGCGGGCTTTGAAGACTGCTTGGTATT
TGATGAGTTAATGGACAAATTCAATAATGATCTTAGTGTGTGCCTTCCTGAATTCTCAAGATTT
AGGATTCCTGATGACCATGCAATTTCAGACCTGTCTATGTACAATTACATAGAGATGCGAGCGC
ATGTCAACTCTAGGTGGTTCCTGTTTCAAAGGCTCCTGGATAAATTTCTTCATGCACTAATGCC
ATCCACTTTCATCCCTCTCTATACCATGGTCGCCTTCACCAGAATAAGATACCACGAGGCAGTG
CTGCGCTGGCATTGGCAAAAAAAGGTGATAAACAGAGGACTCTTTGTCCTTGGGTCCCTGGTAG
CCATTGGAAGTGCCTACATACTCGTGCACCACCTGTCCCCGAGACCTCTGGAACTCCTGAGATC
TGCCTGGACGGGAACCTCTGGCCACTGGAATAGGAGTGCAGACATTTCTCCACGAGTTCCATGG
AGTCACTAGGACAAATGCCCCAGTTCACTATCCATAGTGTCAACGTTCCGGGTAGCAAATGCTT
GATTCCTCTTCAATATCAAGGGAGAAACTCATGTTCCCATTGCCGTCTTCAGTTCACTATGGGA
AAATCATTGTCAGCATATAATTAAGTTCGGAGTGGAGGGCTGTTTTTACAGTGTCTCATTATTT
TGCATGCTTGGACTGGGTTCAATTTTTAAATTTAAAAACACAATAACCAAAAAAAAAAAAAAAA
AAAAA

hide sequence

RefSeq Acc Id:

XM_006250325 ⟹ XP_006250387

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	87,557,080 - 87,588,284 (+)	NCBI
Rnor_6.0	13	93,684,326 - 93,715,378 (+)	NCBI
Rnor_5.0	13	98,149,340 - 98,180,255 (+)	NCBI

Sequence:

show sequence

TTTTGGTTATCGCAGTGAGCTGTCTCCAAGAGCCAAGCTGATTGGACTTTGGGCTTCTAGTGAG
TTAAACACTATCAGAGGAAGTGAGCTTTGACCAAACCTTGCTTCTGGCTCACAAAGGCTCTGGG
CTTCTGGCAATAAAAAGATCACAAAACATCAGCATGTAGTGCAGAGAGTTCCTACCTGAGCAGA
GGTATTCTGGCAGCAATGGCATCGTCGGACACTGAAGGAAAAAGAGTGGTTGTTATCGGTGGTG
GTTTGGTTGGAGCATTGAACGCGTGCTTTCTCGCAAAGAGGAATTTCCAAGTTGATGTGTACGA
AGCTAGGGAAGATATTCGAGTGGCTAACTTTATGCGTGGAAGAAGCATTAATTTGGCCCTTTCT
TATAGAGGACGGCAGGCCTTGAAGGCCGTTGGTCTGGAAGATCAGATCGTGTCCAAAGGTGTGC
CCATGAAAGCCAGAATGATCCACTCTCTCTCGGGAAAGAAGTCTGCAATTCCCTATGGGAACAA
GTCACAGTATATCCTTTCAATAAGCAGAGAAAAGTTAAACAAGGATCTGCTGACTGCCGTGGAG
TCCTACCCCAATGCAAAGGTGCACTTTGGCCACAAGCTGTCAAAATGCTGTCCGGAGGAAGGGA
TACTCACGATGCTTGGACCCAACAAAGTTCCCAGAGACATCACGTGTGACCTCATTGTAGGATG
TGATGGGGCCTACTCAACTGTCAGAGCTCACCTCATGAAGAAGCCCCGTTTTGATTACAGTCAG
CAATATATCCCTCATGGCTATATGGAGCTGACAATTCCACCTAAGAACGGGGAGTATGCCATGG
AACCTAACTGTCTTCACATTTGGCCTAGAAATGCCTTTATGATGATCGCCCTACCGAACATGGA
CAAATCTTTCACATGCACCTTGTTCATGTCCTTTGAGGAGTTTGAAAAGCTTCCAACGCATAGT
GATGTGCTGGACTTCTTCCAGAAGAACTTTCCAGATGCCATCCCTCTGATGGGCGAGCAAGCCC
TCATGAGAGATTTCTTTCTGTTGCCTGCCCAGCCCATGATATCAGTAAAGTGCTCTCCCTTCCA
CCTGAAGTCACGCTGTGTGCTGATGGGAGATGCAGCTCATGCCATCGTCCCATTTTTTGGGCAA
GGAATGAATGCGGGCTTTGAAGACTGCTTGGTATTTGATGAGTTAATGGACAAATTCAATAATG
ATCTTAGTGTGTGCCTTCCTGAATTCTCAAGATTTAGGATTCCTGATGACCATGCAATTTCAGA
CCTGTCTATGTACAATTACATAGAGATGCGAGCGCATGTCAACTCTAGGTGGTTCCTGTTTCAA
AGGCTCCTGGATAAATTTCTTCATGCACTAATGCCATCCACTTTCATCCCTCTCTATACCATGG
TCGCCTTCACCAGAATAAGATACCACGAGGCAGTGCTGCGCTGGCATTGGCAAAAAAAGATAAA
ACCTGTCTCGAGTCTACAGACTGTGGAACATGCACTCTACCTATGGGGGTGGGGAAGCAAAGAG
AACTTGGTGATAAACAGAGGACTCTTTGTCCTTGGGTCCCTGGTAGCCATTGGAAGTGCCTACA
TACTCGTGCACCACCTGTCCCCGAGACCTCTGGAACTCCTGAGATCTGCCTGGACGGGAACCTC
TGGCCACTGGAATAGGAGTGCAGACATTTCTCCACGAGTTCCATGGAGTCACTAGGACAAATGC
CCCAGTTCACTATCCATAGTGTCAACGTTCCGGGTAGCAAATGCTTGATTCCTCTTCAATATCA
AGGGAGAAACTCATGTTCCCATTGCCGTCTTCAGTTCACTATGGGAAAATCATTGTCAGCATAT
AATTAAGTTCGGAGTGGAGGGCTGTTTTTACAGTGTCTCATTATTTTGCATGCTTGGACTGGGT
TCAATTTTTAAATTTAAAAACACAATAACCAAAGTCTCTTTCACTTCTCAAAAAAATTTTTTTT
CCTATAGAGGACAATACAGGATCAAAAACACCAGGACTGAAAACCACAGCTTGCCTGGTGCTAA
TTCCTCTTTATAGCAGTGGTGGGGTTTGCTAGTTCATAGCCACTTGCTAAAGGTAGAGGTGTGA
ATGTTCCAAACAGGGTGTTCCAAAGAGTTCCAGGATAAATCTGTTAAATTATTTCCCAGTCCCC
AGACCTCAGAATTATTACTGTTTTGAAGATAAGGAAAGGGCTATTAATGGCATCTTAAGTGAAG
GATAAGAAAGGGTTGTTAGTAGTAATACATTTATACCAGGGTGGAGAGGAGATGGGAGGGTGTT
TTCTAGAAGCATAGAGACGCACAGTTCATTGCATTTCAGACATGCAGAAGTGATTCGTTGACTG
TCCCACAGACAGAATCGGAAGTTAACTTCATCATCAGAGACTGGGACACTTAGAAATTCTTTTC
ATTGTCAATTTTGAGAGCTACAATAATAGTTATCTAGGAAATCCAAAACTGAGGTTATAAAGAT
AAAACAATTTGGCATTTTCCATAATGCCAAAAGCATCCTCGAGTCTTAACAGTCTATGTTTGAG
GTGTAGGGAAAGAAAAATCATTCTTTTCCTGGTAAGGGATGTAGCTCAGTGGGGAGTGTAGCAT
GGGTAGAGCCCAGGGTTAGATTCACCAGCACTGCAAAAATAAACAGAACAATAGTTTAGGAGCA
TGCATGTATATTTCATATGGACATGGGAAACGCTCAGAAATGAGCTGACTTAGGGGCTAGGGAG
ATGGCTCAGCTGTTAAGTATGTGTGCCACTCCTGAAGAGGCTCCTAGTTCCGTCCCCAGCACCC
ATTTCAGGCAGCCCAGTTGGAACTCCAGCTCCAGGAGATCCAACCCCTCTGGCTTCCTTGGGCC
CCTGCACCCATGTGCATATAACCACACATGGCTCCACAAGGGAATTAAAAGTCTTTAACAATCA
TAATTTCTGGAAGAGGCAAGGGGGTGTATGGGAGGAGTTAGAC

hide sequence

RefSeq Acc Id:

XM_006250327 ⟹ XP_006250389

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	87,557,286 - 87,588,284 (+)	NCBI
Rnor_6.0	13	93,684,324 - 93,715,378 (+)	NCBI
Rnor_5.0	13	98,149,340 - 98,180,255 (+)	NCBI

Sequence:

show sequence

AATTTTGGTTATCGCAGTGAGCTGTCTCCAAGAGCCAAGCTGATTGGACTTTGGGCTTCTAGTG
AGTTAAACACTATCAGAGGAAGTGAGCTTTGACCAAACCTTGCTTCTGGCTCACAAAGGCTCTG
GGCTTCTGGCAATAAAAAGATCACAAAACATCAGCATGTAGTGCAGAGAGTTCCTACCTGAGCA
GAGGTATTCTGGCAGCAATGGCATCGTCGGACACTGAAGGAAAAAGAGTGGTTGTTATCGGTGG
TGGTTTGGTTGGAGCATTGAACGCGTGCTTTCTCGCAAAGAGGAATTTCCAAGTTGATGTGTAC
GAAGCTAGGGAAGATCGTGTCCAAAGGTGTGCCCATGAAAGCCAGAATGATCCACTCTCTCTCG
GGAAAGAAGTCTGCAATTCCCTATGGGAACAAGTCACAGTATATCCTTTCAATAAGCAGAGAAA
AGTTAAACAAGGATCTGCTGACTGCCGTGGAGTCCTACCCCAATGCAAAGGTGCACTTTGGCCA
CAAGCTGTCAAAATGCTGTCCGGAGGAAGGGATACTCACGATGCTTGGACCCAACAAAGTTCCC
AGAGACATCACGTGTGACCTCATTGTAGGATGTGATGGGGCCTACTCAACTGTCAGAGCTCACC
TCATGAAGAAGCCCCGTTTTGATTACAGTCAGCAATATATCCCTCATGGCTATATGGAGCTGAC
AATTCCACCTAAGAACGGGGAGTATGCCATGGAACCTAACTGTCTTCACATTTGGCCTAGAAAT
GCCTTTATGATGATCGCCCTACCGAACATGGACAAATCTTTCACATGCACCTTGTTCATGTCCT
TTGAGGAGTTTGAAAAGCTTCCAACGCATAGTGATGTGCTGGACTTCTTCCAGAAGAACTTTCC
AGATGCCATCCCTCTGATGGGCGAGCAAGCCCTCATGAGAGATTTCTTTCTGTTGCCTGCCCAG
CCCATGATATCAGTAAAGTGCTCTCCCTTCCACCTGAAGTCACGCTGTGTGCTGATGGGAGATG
CAGCTCATGCCATCGTCCCATTTTTTGGGCAAGGAATGAATGCGGGCTTTGAAGACTGCTTGGT
ATTTGATGAGTTAATGGACAAATTCAATAATGATCTTAGTGTGTGCCTTCCTGAATTCTCAAGA
TTTAGGATTCCTGATGACCATGCAATTTCAGACCTGTCTATGTACAATTACATAGAGATGCGAG
CGCATGTCAACTCTAGGTGGTTCCTGTTTCAAAGGCTCCTGGATAAATTTCTTCATGCACTAAT
GCCATCCACTTTCATCCCTCTCTATACCATGGTCGCCTTCACCAGAATAAGATACCACGAGGCA
GTGCTGCGCTGGCATTGGCAAAAAAAGATAAAACCTGTCTCGAGTCTACAGACTGTGGAACATG
CACTCTACCTATGGGGGTGGGGAAGCAAAGAGAACTTGGTGATAAACAGAGGACTCTTTGTCCT
TGGGTCCCTGGTAGCCATTGGAAGTGCCTACATACTCGTGCACCACCTGTCCCCGAGACCTCTG
GAACTCCTGAGATCTGCCTGGACGGGAACCTCTGGCCACTGGAATAGGAGTGCAGACATTTCTC
CACGAGTTCCATGGAGTCACTAGGACAAATGCCCCAGTTCACTATCCATAGTGTCAACGTTCCG
GGTAGCAAATGCTTGATTCCTCTTCAATATCAAGGGAGAAACTCATGTTCCCATTGCCGTCTTC
AGTTCACTATGGGAAAATCATTGTCAGCATATAATTAAGTTCGGAGTGGAGGGCTGTTTTTACA
GTGTCTCATTATTTTGCATGCTTGGACTGGGTTCAATTTTTAAATTTAAAAACACAATAACCAA
AGTCTCTTTCACTTCTCAAAAAAATTTTTTTTCCTATAGAGGACAATACAGGATCAAAAACACC
AGGACTGAAAACCACAGCTTGCCTGGTGCTAATTCCTCTTTATAGCAGTGGTGGGGTTTGCTAG
TTCATAGCCACTTGCTAAAGGTAGAGGTGTGAATGTTCCAAACAGGGTGTTCCAAAGAGTTCCA
GGATAAATCTGTTAAATTATTTCCCAGTCCCCAGACCTCAGAATTATTACTGTTTTGAAGATAA
GGAAAGGGCTATTAATGGCATCTTAAGTGAAGGATAAGAAAGGGTTGTTAGTAGTAATACATTT
ATACCAGGGTGGAGAGGAGATGGGAGGGTGTTTTCTAGAAGCATAGAGACGCACAGTTCATTGC
ATTTCAGACATGCAGAAGTGATTCGTTGACTGTCCCACAGACAGAATCGGAAGTTAACTTCATC
ATCAGAGACTGGGACACTTAGAAATTCTTTTCATTGTCAATTTTGAGAGCTACAATAATAGTTA
TCTAGGAAATCCAAAACTGAGGTTATAAAGATAAAACAATTTGGCATTTTCCATAATGCCAAAA
GCATCCTCGAGTCTTAACAGTCTATGTTTGAGGTGTAGGGAAAGAAAAATCATTCTTTTCCTGG
TAAGGGATGTAGCTCAGTGGGGAGTGTAGCATGGGTAGAGCCCAGGGTTAGATTCACCAGCACT
GCAAAAATAAACAGAACAATAGTTTAGGAGCATGCATGTATATTTCATATGGACATGGGAAACG
CTCAGAAATGAGCTGACTTAGGGGCTAGGGAGATGGCTCAGCTGTTAAGTATGTGTGCCACTCC
TGAAGAGGCTCCTAGTTCCGTCCCCAGCACCCATTTCAGGCAGCCCAGTTGGAACTCCAGCTCC
AGGAGATCCAACCCCTCTGGCTTCCTTGGGCCCCTGCACCCATGTGCATATAACCACACATGGC
TCCACAAGGGAATTAAAAGTCTTTAACAATCATAATTTCTGGAAGAGGCAAGGGGGTGTATGGG
AGGAGTTAGAC

hide sequence

RefSeq Acc Id:

XM_008769795 ⟹ XP_008768017

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	87,574,160 - 87,588,284 (+)	NCBI
Rnor_6.0	13	93,702,100 - 93,715,378 (+)	NCBI

Sequence:

show sequence

CTTTCTCTCCACAGTGTTCTTTCTCTCCTCCCCCTTCGCCCTGTAAGCATTGCGGCTAGCCTTC
CACATATAAGGACGGTATAACCATTGGTCCAACCAGCCTCTGATCAAACGTAGCCAAAACAGAG
ATTTGCATCTCCAAGGAAACACAAAGATCAAAGTTCTCTGTGTTGAGCGGGCACAGACTTTTGC
TCTTGCCCTTGCTCCCTAAAGATACAACCTCTCACACAGCATTTCTAGAAGGAAGTTGAAGCAT
CCAGGAGGGCGTGCATAGGACATATGCAAATGCTATGCTGTTTTACACAAGGAACTTGAGTGTC
TGCAAATTTGGATATGCTTGCTGCTACACTTTGGGACTGCTTTTCCGTTTTCTCTCGACTTCCT
TCCTCCGTCTCTCACCCTTCTGGAGATCACATTCCTCTTTGGTATCAGGACCCAACAAAGTTCC
CAGAGACATCACGTGTGACCTCATTGTAGGATGTGATGGGGCCTACTCAACTGTCAGAGCTCAC
CTCATGAAGAAGCCCCGTTTTGATTACAGTCAGCAATATATCCCTCATGGCTATATGGAGCTGA
CAATTCCACCTAAGAACGGGGAGTATGCCATGGAACCTAACTGTCTTCACATTTGGCCTAGAAA
TGCCTTTATGATGATCGCCCTACCGAACATGGACAAATCTTTCACATGCACCTTGTTCATGTCC
TTTGAGGAGTTTGAAAAGCTTCCAACGCATAGTGATGTGCTGGACTTCTTCCAGAAGAACTTTC
CAGATGCCATCCCTCTGATGGGCGAGCAAGCCCTCATGAGAGATTTCTTTCTGTTGCCTGCCCA
GCCCATGATATCAGTAAAGTGCTCTCCCTTCCACCTGAAGTCACGCTGTGTGCTGATGGGAGAT
GCAGCTCATGCCATCGTCCCATTTTTTGGGCAAGGAATGAATGCGGGCTTTGAAGACTGCTTGG
TATTTGATGAGTTAATGGACAAATTCAATAATGATCTTAGTGTGTGCCTTCCTGAATTCTCAAG
ATTTAGGATTCCTGATGACCATGCAATTTCAGACCTGTCTATGTACAATTACATAGAGATGCGA
GCGCATGTCAACTCTAGGTGGTTCCTGTTTCAAAGGCTCCTGGATAAATTTCTTCATGCACTAA
TGCCATCCACTTTCATCCCTCTCTATACCATGGTCGCCTTCACCAGAATAAGATACCACGAGGC
AGTGCTGCGCTGGCATTGGCAAAAAAAGATAAAACCTGTCTCGAGTCTACAGACTGTGGAACAT
GCACTCTACCTATGGGGGTGGGGAAGCAAAGAGAACTTGGTGATAAACAGAGGACTCTTTGTCC
TTGGGTCCCTGGTAGCCATTGGAAGTGCCTACATACTCGTGCACCACCTGTCCCCGAGACCTCT
GGAACTCCTGAGATCTGCCTGGACGGGAACCTCTGGCCACTGGAATAGGAGTGCAGACATTTCT
CCACGAGTTCCATGGAGTCACTAGGACAAATGCCCCAGTTCACTATCCATAGTGTCAACGTTCC
GGGTAGCAAATGCTTGATTCCTCTTCAATATCAAGGGAGAAACTCATGTTCCCATTGCCGTCTT
CAGTTCACTATGGGAAAATCATTGTCAGCATATAATTAAGTTCGGAGTGGAGGGCTGTTTTTAC
AGTGTCTCATTATTTTGCATGCTTGGACTGGGTTCAATTTTTAAATTTAAAAACACAATAACCA
AAGTCTCTTTCACTTCTCAAAAAAATTTTTTTTCCTATAGAGGACAATACAGGATCAAAAACAC
CAGGACTGAAAACCACAGCTTGCCTGGTGCTAATTCCTCTTTATAGCAGTGGTGGGGTTTGCTA
GTTCATAGCCACTTGCTAAAGGTAGAGGTGTGAATGTTCCAAACAGGGTGTTCCAAAGAGTTCC
AGGATAAATCTGTTAAATTATTTCCCAGTCCCCAGACCTCAGAATTATTACTGTTTTGAAGATA
AGGAAAGGGCTATTAATGGCATCTTAAGTGAAGGATAAGAAAGGGTTGTTAGTAGTAATACATT
TATACCAGGGTGGAGAGGAGATGGGAGGGTGTTTTCTAGAAGCATAGAGACGCACAGTTCATTG
CATTTCAGACATGCAGAAGTGATTCGTTGACTGTCCCACAGACAGAATCGGAAGTTAACTTCAT
CATCAGAGACTGGGACACTTAGAAATTCTTTTCATTGTCAATTTTGAGAGCTACAATAATAGTT
ATCTAGGAAATCCAAAACTGAGGTTATAAAGATAAAACAATTTGGCATTTTCCATAATGCCAAA
AGCATCCTCGAGTCTTAACAGTCTATGTTTGAGGTGTAGGGAAAGAAAAATCATTCTTTTCCTG
GTAAGGGATGTAGCTCAGTGGGGAGTGTAGCATGGGTAGAGCCCAGGGTTAGATTCACCAGCAC
TGCAAAAATAAACAGAACAATAGTTTAGGAGCATGCATGTATATTTCATATGGACATGGGAAAC
GCTCAGAAATGAGCTGACTTAGGGGCTAGGGAGATGGCTCAGCTGTTAAGTATGTGTGCCACTC
CTGAAGAGGCTCCTAGTTCCGTCCCCAGCACCCATTTCAGGCAGCCCAGTTGGAACTCCAGCTC
CAGGAGATCCAACCCCTCTGGCTTCCTTGGGCCCCTGCACCCATGTGCATATAACCACACATGG
CTCCACAAGGGAATTAAAAGTCTTTAACAATCATAATTTCTGGAAGAGGCAAGGGGGTGTATGG
GAGGAGTTAGAC

hide sequence

RefSeq Acc Id:

XM_039091044 ⟹ XP_038946972

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	87,557,324 - 87,589,334 (+)	NCBI

RefSeq Acc Id:

XM_039091045 ⟹ XP_038946973

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	87,557,387 - 87,588,284 (+)	NCBI

RefSeq Acc Id:

XM_039091046 ⟹ XP_038946974

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	87,557,324 - 87,583,128 (+)	NCBI

RefSeq Acc Id:

XM_039091047 ⟹ XP_038946975

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	87,575,721 - 87,588,284 (+)	NCBI

RefSeq Acc Id:

XR_005492281

RefSeq Status:

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	87,557,324 - 87,585,148 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_067604	(Get FASTA)	NCBI Sequence Viewer
	XP_006250387	(Get FASTA)	NCBI Sequence Viewer
	XP_006250389	(Get FASTA)	NCBI Sequence Viewer
	XP_008768017	(Get FASTA)	NCBI Sequence Viewer
	XP_038946972	(Get FASTA)	NCBI Sequence Viewer
	XP_038946973	(Get FASTA)	NCBI Sequence Viewer
	XP_038946974	(Get FASTA)	NCBI Sequence Viewer
	XP_038946975	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC62614	(Get FASTA)	NCBI Sequence Viewer
	AAH88142	(Get FASTA)	NCBI Sequence Viewer
	EDL94770	(Get FASTA)	NCBI Sequence Viewer
	O88867	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_067604 ⟸ NM_021593

- UniProtKB:

O88867 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MASSDTEGKRVVVIGGGLVGALNACFLAKRNFQVDVYEAREDIRVANFMRGRSINLALSYRGRQ
ALKAVGLEDQIVSKGVPMKARMIHSLSGKKSAIPYGNKSQYILSISREKLNKDLLTAVESYPNA
KVHFGHKLSKCCPEEGILTMLGPNKVPRDITCDLIVGCDGAYSTVRAHLMKKPRFDYSQQYIPH
GYMELTIPPKNGEYAMEPNCLHIWPRNAFMMIALPNMDKSFTCTLFMSFEEFEKLPTHSDVLDF
FQKNFPDAIPLMGEQALMRDFFLLPAQPMISVKCSPFHLKSRCVLMGDAAHAIVPFFGQGMNAG
FEDCLVFDELMDKFNNDLSVCLPEFSRFRIPDDHAISDLSMYNYIEMRAHVNSRWFLFQRLLDK
FLHALMPSTFIPLYTMVAFTRIRYHEAVLRWHWQKKVINRGLFVLGSLVAIGSAYILVHHLSPR
PLELLRSAWTGTSGHWNRSADISPRVPWSH

hide sequence

RefSeq Acc Id:

XP_006250389 ⟸ XM_006250327

- Peptide Label:

isoform X2

- Sequence:

show sequence

MCTKLGKIVSKGVPMKARMIHSLSGKKSAIPYGNKSQYILSISREKLNKDLLTAVESYPNAKVH
FGHKLSKCCPEEGILTMLGPNKVPRDITCDLIVGCDGAYSTVRAHLMKKPRFDYSQQYIPHGYM
ELTIPPKNGEYAMEPNCLHIWPRNAFMMIALPNMDKSFTCTLFMSFEEFEKLPTHSDVLDFFQK
NFPDAIPLMGEQALMRDFFLLPAQPMISVKCSPFHLKSRCVLMGDAAHAIVPFFGQGMNAGFED
CLVFDELMDKFNNDLSVCLPEFSRFRIPDDHAISDLSMYNYIEMRAHVNSRWFLFQRLLDKFLH
ALMPSTFIPLYTMVAFTRIRYHEAVLRWHWQKKIKPVSSLQTVEHALYLWGWGSKENLVINRGL
FVLGSLVAIGSAYILVHHLSPRPLELLRSAWTGTSGHWNRSADISPRVPWSH

hide sequence

RefSeq Acc Id:

XP_006250387 ⟸ XM_006250325

- Peptide Label:

isoform X1

- Sequence:

show sequence

MASSDTEGKRVVVIGGGLVGALNACFLAKRNFQVDVYEAREDIRVANFMRGRSINLALSYRGRQ
ALKAVGLEDQIVSKGVPMKARMIHSLSGKKSAIPYGNKSQYILSISREKLNKDLLTAVESYPNA
KVHFGHKLSKCCPEEGILTMLGPNKVPRDITCDLIVGCDGAYSTVRAHLMKKPRFDYSQQYIPH
GYMELTIPPKNGEYAMEPNCLHIWPRNAFMMIALPNMDKSFTCTLFMSFEEFEKLPTHSDVLDF
FQKNFPDAIPLMGEQALMRDFFLLPAQPMISVKCSPFHLKSRCVLMGDAAHAIVPFFGQGMNAG
FEDCLVFDELMDKFNNDLSVCLPEFSRFRIPDDHAISDLSMYNYIEMRAHVNSRWFLFQRLLDK
FLHALMPSTFIPLYTMVAFTRIRYHEAVLRWHWQKKIKPVSSLQTVEHALYLWGWGSKENLVIN
RGLFVLGSLVAIGSAYILVHHLSPRPLELLRSAWTGTSGHWNRSADISPRVPWSH

hide sequence

RefSeq Acc Id:

XP_008768017 ⟸ XM_008769795

- Peptide Label:

isoform X4

- Sequence:

show sequence

MLFYTRNLSVCKFGYACCYTLGLLFRFLSTSFLRLSPFWRSHSSLVSGPNKVPRDITCDLIVGC
DGAYSTVRAHLMKKPRFDYSQQYIPHGYMELTIPPKNGEYAMEPNCLHIWPRNAFMMIALPNMD
KSFTCTLFMSFEEFEKLPTHSDVLDFFQKNFPDAIPLMGEQALMRDFFLLPAQPMISVKCSPFH
LKSRCVLMGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFNNDLSVCLPEFSRFRIPDDHAISD
LSMYNYIEMRAHVNSRWFLFQRLLDKFLHALMPSTFIPLYTMVAFTRIRYHEAVLRWHWQKKIK
PVSSLQTVEHALYLWGWGSKENLVINRGLFVLGSLVAIGSAYILVHHLSPRPLELLRSAWTGTS
GHWNRSADISPRVPWSH

hide sequence

RefSeq Acc Id:

ENSRNOP00000005005 ⟸ ENSRNOT00000005005

RefSeq Acc Id:	XP_038946972 ⟸ XM_039091044
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038946974 ⟸ XM_039091046
- Peptide Label:	isoform X5

RefSeq Acc Id:	XP_038946973 ⟸ XM_039091045
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038946975 ⟸ XM_039091047
- Peptide Label:	isoform X6

RefSeq Acc Id:

ENSRNOP00000095165 ⟸ ENSRNOT00000100456

RefSeq Acc Id:

ENSRNOP00000097495 ⟸ ENSRNOT00000114438

Protein Domains

FAD-binding

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O88867-F1-model_v2	AlphaFold	O88867	1-478	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699041

Promoter ID:

EPDNEW_R9565

Type:

initiation region

Name:

Kmo_1

Description:

kynurenine 3-monooxygenase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	13	93,684,491 - 93,684,551	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620610	AgrOrtholog
BioCyc Gene	G2FUF-17232	BioCyc
BioCyc Pathway	PWY-5651 [L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde]	BioCyc
Ensembl Genes	ENSRNOG00000003709	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000005005	ENTREZGENE
	ENSRNOP00000005005.3	UniProtKB/Swiss-Prot
	ENSRNOP00000095165.1	UniProtKB/TrEMBL
	ENSRNOP00000097495.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000005005	ENTREZGENE
	ENSRNOT00000005005.7	UniProtKB/Swiss-Prot
	ENSRNOT00000100456.1	UniProtKB/TrEMBL
	ENSRNOT00000114438.1	UniProtKB/TrEMBL
Gene3D-CATH	3.50.50.60	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7322842	IMAGE-MGC_LOAD
InterPro	FAD-bd	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	FAD/NAD-bd_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Kynurenine_monooxygenase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:59113	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:108700	IMAGE-MGC_LOAD
NCBI Gene	59113	ENTREZGENE
PANTHER	KYNURENINE 3-MONOOXYGENASE	UniProtKB/Swiss-Prot
	KYNURENINE 3-MONOOXYGENASE	UniProtKB/Swiss-Prot
	KYNURENINE 3-MONOOXYGENASE	UniProtKB/TrEMBL
	KYNURENINE 3-MONOOXYGENASE	UniProtKB/TrEMBL
Pfam	FAD_binding_3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Kmo	PhenoGen
PRINTS	RNGMNOXGNASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF51905	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6AJ51_RAT	UniProtKB/TrEMBL
	A0A8I6AUG8_RAT	UniProtKB/TrEMBL
	KMO_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-25	Kmo	kynurenine 3-monooxygenase	Kmo	kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Kmo	kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)		kynurenine 3-hydroxylase	Name updated	1299863	APPROVED
2002-08-07	Kmo	kynurenine 3-hydroxylase			Symbol and Name status set to provisional	70820	PROVISIONAL

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Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)