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Gene: Neil3 (nei-like DNA glycosylase 3) Rattus norvegicus

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Symbol:

Neil3

Name:

nei-like DNA glycosylase 3

RGD ID:

1310562

Description:

Predicted to enable DNA binding activity and catalytic activity, acting on DNA. Predicted to be involved in base-excision repair and single strand break repair. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to human NEIL3 (nei like DNA glycosylase 3); PARTICIPATES IN base excision repair pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

endonuclease 8-like 3; endonuclease VIII-like 3; LOC290729; nei endonuclease VIII-like 3; nei endonuclease VIII-like 3 (E. coli); nei like 3; nei like 3 (E. coli); RGD1310562; similar to putative DNA glycosylase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NEIL3 (nei like DNA glycosylase 3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Neil3 (nei like 3 (E. coli))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Neil3 (nei like DNA glycosylase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	NEIL3 (nei like DNA glycosylase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	NEIL3 (nei like DNA glycosylase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Neil3 (nei like DNA glycosylase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	NEIL3 (nei like DNA glycosylase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	NEIL3 (nei like DNA glycosylase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Neil3 (nei like DNA glycosylase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	NEIL3 (nei like DNA glycosylase 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Neil3 (nei like 3 (E. coli))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	neil3 (nei-like DNA glycosylase 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	neil3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	neil3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	45,091,401 - 45,151,419 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	16	45,092,200 - 45,151,205 (+)	Ensembl				GRCr8
mRatBN7.2	16	38,359,305 - 38,418,528 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	38,359,371 - 38,418,527 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	16	43,706,773 - 43,765,823 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	47,067,373 - 47,126,419 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	42,424,712 - 42,483,736 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	41,079,444 - 41,138,505 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	41,079,444 - 41,138,505 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	16	40,809,785 - 40,908,566 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	16	41,232,815 - 41,296,032 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	16	36,461,541 - 36,520,332 (+)	NCBI		Celera
RGSC_v3.1	16	41,232,999 - 41,296,066 (+)	NCBI
Cytogenetic Map	16	p11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

hepatocellular carcinoma (ISO)

Neurodevelopmental Disorders (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

(-)-epigallocatechin 3-gallate (ISO)

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

1-naphthyl isothiocyanate (EXP)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,4'-trichlorobiphenyl (ISO)

2,4-diaminotoluene (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2-palmitoylglycerol (ISO)

4-hydroxynon-2-enal (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bis(2-chloroethyl) sulfide (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

calcitriol (ISO)

cannabidiol (ISO)

carbon nanotube (ISO)

choline (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

DDE (ISO)

deguelin (ISO)

diallyl trisulfide (ISO)

dioxygen (ISO)

endosulfan (ISO)

Enterolactone (ISO)

ethyl methanesulfonate (ISO)

folic acid (ISO)

fonofos (ISO)

glyphosate (ISO)

L-methionine (ISO)

lead(0) (ISO)

lidocaine (EXP)

methotrexate (ISO)

methyl methanesulfonate (ISO)

Monobutylphthalate (EXP)

N-methyl-4-phenylpyridinium (ISO)

N-Nitrosopyrrolidine (ISO)

okadaic acid (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

paraquat (EXP,ISO)

PCB138 (ISO)

picoxystrobin (ISO)

potassium chromate (ISO)

propanal (ISO)

quinolin-8-ol (ISO)

resveratrol (ISO)

rotenone (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sulforaphane (ISO)

sunitinib (ISO)

testosterone (ISO)

tributylstannane (EXP)

trimellitic anhydride (ISO)

troglitazone (ISO)

trovafloxacin (ISO)

tungsten (ISO)

urethane (ISO)

valproic acid (ISO)

zaragozic acid A (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

base-excision repair (IBA,IEA,ISO)

DNA damage response (IEA)

DNA repair (IEA)

single strand break repair (IEA,ISO)

Cellular Component

chromosome (IEA)

nucleoplasm (IEA,ISO)

nucleus (IBA,IEA,ISO)

Molecular Function

bubble DNA binding (IEA,ISO)

catalytic activity (IEA)

class I DNA-(apurinic or apyrimidinic site) endonuclease activity (IEA)

damaged DNA binding (IEA)

DNA binding (IEA)

DNA N-glycosylase activity (IBA,IEA,ISO)

DNA-(apurinic or apyrimidinic site) endonuclease activity (IBA,IEA,ISO)

double-stranded DNA binding (IEA,ISO)

hydrolase activity (IEA)

hydrolase activity, acting on glycosyl bonds (IEA)

hydrolase activity, hydrolyzing N-glycosyl compounds (IEA)

lyase activity (IEA)

metal ion binding (IEA)

nucleic acid binding (IEA)

single-stranded DNA binding (IEA,ISO)

zinc ion binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

base excision repair pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Comprehensive Molecular Analyses of a Macrophage-Related Gene Signature With Regard to Prognosis, Immune Features, and Biomarkers for Immunotherapy in Hepatocellular Carcinoma Based on WGCNA and the LASSO Algorithm.	Wang T, etal., Front Immunol. 2022 May 27;13:843408. doi: 10.3389/fimmu.2022.843408. eCollection 2022.

Additional References at PubMed

PMID:12433996	PMID:16428305	PMID:19170771	PMID:20185759	PMID:22564741	PMID:23755964

Genomics

Comparative Map Data

Neil3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	45,091,401 - 45,151,419 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	16	45,092,200 - 45,151,205 (+)	Ensembl				GRCr8
mRatBN7.2	16	38,359,305 - 38,418,528 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	38,359,371 - 38,418,527 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	16	43,706,773 - 43,765,823 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	47,067,373 - 47,126,419 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	42,424,712 - 42,483,736 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	41,079,444 - 41,138,505 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	41,079,444 - 41,138,505 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	16	40,809,785 - 40,908,566 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	16	41,232,815 - 41,296,032 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	16	36,461,541 - 36,520,332 (+)	NCBI		Celera
RGSC_v3.1	16	41,232,999 - 41,296,066 (+)	NCBI
Cytogenetic Map	16	p11	NCBI

NEIL3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	177,309,874 - 177,371,268 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	177,309,874 - 177,362,936 (+)	Ensembl			hg38	GRCh38
GRCh37	4	178,231,028 - 178,284,090 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	178,467,985 - 178,521,086 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	4	178,606,176 - 178,659,149	NCBI
Celera	4	175,558,124 - 175,611,235 (+)	NCBI		Celera
Cytogenetic Map	4	q34.3	NCBI
HuRef	4	173,981,363 - 174,034,490 (+)	NCBI		HuRef
CHM1_1	4	178,207,145 - 178,260,553 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	4	180,648,665 - 180,701,747 (+)	NCBI		T2T-CHM13v2.0

Neil3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	54,039,902 - 54,092,100 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	54,039,902 - 54,092,100 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	8	53,586,867 - 53,639,065 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	53,586,867 - 53,639,065 (-)	Ensembl			mm10	GRCm38
MGSCv37	8	54,672,221 - 54,724,419 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	8	55,085,565 - 55,137,693 (-)	NCBI		MGSCv36	mm8
Celera	8	56,300,317 - 56,352,663 (-)	NCBI		Celera
Cytogenetic Map	8	B1.3	NCBI
cM Map	8	29.14	NCBI

Neil3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955403	30,549,740 - 30,591,821 (-)	Ensembl
ChiLan1.0	NW_004955403	30,549,779 - 30,591,757 (-)	NCBI	ChiLan1.0	ChiLan1.0

NEIL3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	175,056,238 - 175,109,146 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	175,420,093 - 175,472,838 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	169,503,942 - 169,556,654 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	181,738,838 - 181,791,757 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	181,738,803 - 181,795,082 (+)	Ensembl			panPan2	panpan1.1

NEIL3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	16	52,383,585 - 52,472,398 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	16	52,387,389 - 52,436,173 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	16	47,883,197 - 47,966,699 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	16	54,692,820 - 54,776,914 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	16	54,698,978 - 54,746,494 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	16	52,588,158 - 52,672,461 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	16	53,183,765 - 53,268,294 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	16	53,420,999 - 53,505,487 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Neil3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404943	27,324,857 - 27,402,022 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936516	7,739,157 - 7,782,024 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936516	7,739,191 - 7,781,735 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NEIL3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	39,581,856 - 39,632,308 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	15	39,416,073 - 39,632,313 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	45,454,240 - 45,542,560 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NEIL3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	123,408,582 - 123,462,475 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	123,409,363 - 123,462,411 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666037	103,527,385 - 103,579,971 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Neil3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624769	8,448,226 - 8,480,439 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624769	8,436,526 - 8,480,336 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Variants

Variants in Neil3
218 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	86
Count of miRNA genes:	72
Interacting mature miRNAs:	78
Transcripts:	ENSRNOT00000015623
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1549842	Bp248	Blood pressure QTL 248		0.01	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	16	387123	45387123	Rat
70215	Niddm29	Non-insulin dependent diabetes mellitus QTL 29	3.54		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	16	36928782	81928782	Rat
1578768	Stresp22	Stress response QTL 22	2.8		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	16	41992064	86992064	Rat
2302057	Pia29	Pristane induced arthritis QTL 29	3.6	0.001	blood autoantibody amount (VT:0003725)	serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)	16	28468701	73468701	Rat
1357403	Slep4	Serum leptin concentration QTL 4	3.91		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	32361043	77361043	Rat
737819	Hcas4	Hepatocarcinoma susceptibility QTL 4	4.43		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	16	4234212	53708481	Rat
1354625	Despr7	Despair related QTL 7	3.16	0.016	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	16	4744222	49744222	Rat
6903294	Stl30	Serum triglyceride level QTL 30	2.6	0.0013	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	16	31885271	76885271	Rat
2293690	Bss45	Bone structure and strength QTL 45	5.13	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	16	44455123	89455123	Rat
2300163	Bmd64	Bone mineral density QTL 64	5.3	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	16	44455123	89455123	Rat
7411664	Foco30	Food consumption QTL 30	11	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	16	4354822	49354822	Rat
1600378	Arunc4	Aerobic running capacity QTL 4		0.03	exercise endurance trait (VT:0002332)	longest distance run on treadmill (CMO:0001406)	16	387123	45387123	Rat
70183	BpQTLcluster13	Blood pressure QTL cluster 13	3.654		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	16	4234212	49757901	Rat
737826	Alc11	Alcohol consumption QTL 11	3.2		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	4234212	66955197	Rat
8694453	Bw172	Body weight QTL 172	8.33	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	16	31058039	76058039	Rat
1298529	Arunc1	Aerobic running capacity QTL 1	4		exercise endurance trait (VT:0002332)	longest distance run on treadmill (CMO:0001406)	16	34398294	79398294	Rat
2312663	Slep9	Serum leptin concentration QTL 9		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	839086	66195506	Rat
2306902	Bp339	Blood pressure QTL 339		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	3386790	49757901	Rat
2312660	Bw95	Body weight QTL 95		0.05	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	16	839086	66195506	Rat
2312666	Insul16	Insulin level QTL 16		0.01	blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	16	839086	66195506	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor diameter (CMO:0001889)	16	17730818	72536785	Rat
2293343	Glom16	Glomerulus QTL 16	7.4		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	16	839086	52786090	Rat
2301406	Kidm39	Kidney mass QTL 39		0.002	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	16	15905802	60905802	Rat
2312669	Stl23	Serum triglyceride level QTL 23		0.01	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	16	839086	66195506	Rat
6903319	Bw114	Body weight QTL 114	2.7	0.0037	body mass (VT:0001259)	body weight (CMO:0000012)	16	3301683	48301683	Rat

Markers in Region

AU047451

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	38,365,495 - 38,365,665 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	41,085,635 - 41,085,804	NCBI	Rnor6.0
Rnor_5.0	16	40,855,482 - 40,855,651	UniSTS	Rnor5.0
RGSC_v3.4	16	41,239,006 - 41,239,175	UniSTS	RGSC3.4
Celera	16	36,467,732 - 36,467,894	UniSTS
Cytogenetic Map	16	p11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	7	57	147	74	75	45	77	45	6	293	161	11	128	66	91	30	13	13

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001170346	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005494578	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005494579	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005494580	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010058285	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473995	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000015623 ⟹ ENSRNOP00000015623

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	16	45,092,200 - 45,151,205 (+)	Ensembl
mRatBN7.2 Ensembl	16	38,359,371 - 38,418,527 (+)	Ensembl
Rnor_6.0 Ensembl	16	41,079,444 - 41,138,505 (+)	Ensembl

RefSeq Acc Id:

NM_001170346 ⟹ NP_001163817

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	16	45,092,200 - 45,151,205 (+)	NCBI
mRatBN7.2	16	38,359,305 - 38,418,314 (+)	NCBI
Rnor_6.0	16	41,079,444 - 41,138,505 (+)	NCBI
Rnor_5.0	16	40,809,785 - 40,908,566 (+)	NCBI
RGSC_v3.4	16	41,232,815 - 41,296,032 (+)	RGD
Celera	16	36,461,541 - 36,520,332 (+)	RGD

Sequence:

show sequence

GAGATTTGAACTTCCTCTCCGCCCAGTCTGTGTGAACAGGAAAGTGAAGTTGCCTGGTTGTTTT
CCAGTCAGGCCTTGCAACTAGCAGGGGTTCCGGGCAGCCTACAGAGATGGTGGAAGGGCCAGGA
TGTACACTGAATGGAGAGAAGATTCGGGCACGAGTGCTACCGGGACAGGCGATGACTGGTGTGC
GGGGAACAGCTCTGCAGGGCCTCTTGGGCTCTGCCTTGTCCCCCGCAGCCTCCCTGGCTGAGGT
CACTAGCTCGGCTGCTCCAATGAACGCTAAAGATTCTGGCTGGAAAGTCTTGAGACTGTTTAAT
GGATGTGTTTACAGTGGTGTGGAAACCTTGGGGAAGGAGCTGTTTATGTACTTTGGCCCAAGAG
CTTTACGGATTCATTTCGGAATGAAAGGCTCCATCTTGATTAACCCGCCTAAGTGTGAAAATAG
AGGTGGAGTTTCTCCAGCTTTTGAAGTGCAGCTCACCAATGACTTGATCTGTTTCTTTGACTCT
TCAGTAAAACTCAGAAATTCAGTGGAAAGCCAACAAAGAGTCAGAATGATGGAAGGATTGGATG
TATGCTCACCAAAGTTCAGTCTCTCAAGAGCAGAAAGTGAAGTTAAGAAGCAGAGAGATCGGAT
GCTGTGTGATGTGTTACTGGATCAGAGGGTGTTGCCTGGTGTAGGGAACATCATCAAAAATGAA
GCTCTCTTTGACAGTGGACTCCATCCAACTGTTAAGGTGTGTCAACTATCAGACAAACAGGCCC
ATCACCTTGTGAAGATGACCCGGGATTTCAGCATTCTCTTCTACAGGTGCCGTAAAGCAGGATC
TGCCATTTCTAAACACTATAAGGTTTATAAGCGTCCTAACTGTGCACAGTGCCACTGCAAAATT
AGAGTGTGTCGCTTAGGGGAGAACAGCAGGATGACGTATTTCTGTCCTCACTGTCAGAAAGAAA
ACCCTCAACATGTTCAAATATGCTCACTGCCTTTCAGAAATGCTGAAATCAGCTGGACTCCTAA
AGGACAGGATTGCTTTACCGACTCAGTAGCTCGGAAGTCTGAAGAGCAGTGGTCCTGCATGGTT
TGCACCCTCATAAACAAACCCTCGGCTACGGCCTGCGATGCTTGCCTGACGACAAGGCCTGTGG
ATTCAGTGCTCAAAAATGAAGAGAATTCCATTGCCTTTAGCAACTTAGTGAAGTACCCTTTTAA
TAACTTTGAGAACACACACACTGAAATAAAGATCAACAGGAAAACTGTGTTTGGAAATACAACC
CTTGTTTTGACTGATTTGAGCAACAAATCTAGTGCTTTGGCCAGAAAAAGCAGCCCAAGCCAGA
CAATAGATGGGGAATCTCAAATTTTTCTTCCTACAGACATATGTTTCAGTGATCCACAGCACAT
CTCCAAAGAAGGAGTAAACTATATAACTCAACCATCCAACAAGGTAAACATGTCGTCCACAGTT
GGTGCCCAGTCTAAATTATTTACTTCAGCACATAAAAAATTGAAAACAGCTCACTCTTTGGCAA
CAGAACTTAAAAGTTACAACTCTGGACTTTCTAACAGTGAACTCCAAACCAATATAAGAAGTGA
TCCTTGTTCTCTACATGCCAGCAGGCCTCAGTGCAAGACGCACAGCCGGCCCTGTGTTCTCCGA
GTTGTGAGGAAGGATGGAGAAAACAAAGGAAGGCAGTTTTATGCATGTTCTCTGCCCAGAGGAG
CACAGTGCGGATTTTTTGAATGGGCAGACCTGTCCTTCCCGTTCTGCGGACATGGCAAGCGCTC
CATTATGAAAACTGTGTTGAAGATTGGACCTAATAATGGGAAGAATTTTTTTGTATGTCCTTTG
GAGAAAGAAAAGCAGTGTAATTTTTTCCAGTGGGCAGAAAGTGGACCAGAAATGGAAATTATTC
CAGGATGCTAATATTTTTCTCTTTTTAAAGAATGACTGCCATATAAACTCATCAA

hide sequence

RefSeq Acc Id:

XR_005494578

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	16	45,092,200 - 45,151,419 (+)	NCBI
mRatBN7.2	16	38,359,307 - 38,418,528 (+)	NCBI

RefSeq Acc Id:

XR_005494579

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	16	45,092,200 - 45,151,419 (+)	NCBI
mRatBN7.2	16	38,359,307 - 38,418,528 (+)	NCBI

RefSeq Acc Id:

XR_005494580

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	16	45,092,225 - 45,151,419 (+)	NCBI
mRatBN7.2	16	38,359,307 - 38,418,528 (+)	NCBI

RefSeq Acc Id:

XR_010058285

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	16	45,091,401 - 45,151,419 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001163817	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL78941	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000015623
	ENSRNOP00000015623.6

RefSeq Acc Id:

NP_001163817 ⟸ NM_001170346

- UniProtKB:

D3ZKJ8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MVEGPGCTLNGEKIRARVLPGQAMTGVRGTALQGLLGSALSPAASLAEVTSSAAPMNAKDSGWK
VLRLFNGCVYSGVETLGKELFMYFGPRALRIHFGMKGSILINPPKCENRGGVSPAFEVQLTNDL
ICFFDSSVKLRNSVESQQRVRMMEGLDVCSPKFSLSRAESEVKKQRDRMLCDVLLDQRVLPGVG
NIIKNEALFDSGLHPTVKVCQLSDKQAHHLVKMTRDFSILFYRCRKAGSAISKHYKVYKRPNCA
QCHCKIRVCRLGENSRMTYFCPHCQKENPQHVQICSLPFRNAEISWTPKGQDCFTDSVARKSEE
QWSCMVCTLINKPSATACDACLTTRPVDSVLKNEENSIAFSNLVKYPFNNFENTHTEIKINRKT
VFGNTTLVLTDLSNKSSALARKSSPSQTIDGESQIFLPTDICFSDPQHISKEGVNYITQPSNKV
NMSSTVGAQSKLFTSAHKKLKTAHSLATELKSYNSGLSNSELQTNIRSDPCSLHASRPQCKTHS
RPCVLRVVRKDGENKGRQFYACSLPRGAQCGFFEWADLSFPFCGHGKRSIMKTVLKIGPNNGKN
FFVCPLEKEKQCNFFQWAESGPEMEIIPGC

hide sequence

Ensembl Acc Id:

ENSRNOP00000015623 ⟸ ENSRNOT00000015623

Protein Domains

Formamidopyrimidine-DNA glycosylase catalytic FPG-type GRF-type RanBP2-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZKJ8-F1-model_v2	AlphaFold	D3ZKJ8	1-606	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700084

Promoter ID:

EPDNEW_R10608

Type:

initiation region

Name:

Neil3_1

Description:

nei-like DNA glycosylase 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	16	41,079,475 - 41,079,535	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310562	AgrOrtholog
BioCyc Gene	G2FUF-11455	BioCyc
Ensembl Genes	ENSRNOG00000011688	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000015623	ENTREZGENE
	ENSRNOT00000015623.7	UniProtKB/TrEMBL
Gene3D-CATH	1.10.8.50	UniProtKB/TrEMBL
	3.20.190.10	UniProtKB/TrEMBL
	Zn-finger domain of Sec23/24	UniProtKB/TrEMBL
InterPro	DNA_glyclase/AP_lyase_DNA-bd	UniProtKB/TrEMBL
	DNA_glyclase/AP_lyase_Znf_dom	UniProtKB/TrEMBL
	DNA_glyclase_Znf_dom_DNA_BS	UniProtKB/TrEMBL
	DNA_glycosylase/AP_lyase_cat	UniProtKB/TrEMBL
	MutM-like_N-ter	UniProtKB/TrEMBL
	Ribosomal_S13-like_H2TH	UniProtKB/TrEMBL
	Znf_GRF	UniProtKB/TrEMBL
	Znf_RanBP2	UniProtKB/TrEMBL
	Znf_RanBP2_sf	UniProtKB/TrEMBL
NCBI Gene	290729	ENTREZGENE
PANTHER	ENDONUCLEASE 8-LIKE 3	UniProtKB/TrEMBL
	FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE	UniProtKB/TrEMBL
Pfam	H2TH	UniProtKB/TrEMBL
	zf-GRF	UniProtKB/TrEMBL
	zf-RanBP	UniProtKB/TrEMBL
PhenoGen	Neil3	PhenoGen
PROSITE	FPG_CAT	UniProtKB/TrEMBL
	ZF_FPG_1	UniProtKB/TrEMBL
	ZF_FPG_2	UniProtKB/TrEMBL
	ZF_GRF	UniProtKB/TrEMBL
	ZF_RANBP2_1	UniProtKB/TrEMBL
	ZF_RANBP2_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000011688	RatGTEx
SMART	H2TH	UniProtKB/TrEMBL
	ZnF_RBZ	UniProtKB/TrEMBL
Superfamily-SCOP	Form_DNAglyc_cat	UniProtKB/TrEMBL
	Ribosomal_H2TH	UniProtKB/TrEMBL
	SSF90209	UniProtKB/TrEMBL
UniProt	D3ZKJ8	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-07-01	Neil3	nei-like DNA glycosylase 3	Neil3	nei endonuclease VIII-like 3 (E. coli)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-25	Neil3	nei endonuclease VIII-like 3 (E. coli)	Neil3	nei like 3 (E. coli)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Neil3	nei like 3 (E. coli)	Neil3_predicted	nei like 3 (E. coli) (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-30	Neil3_predicted	nei like 3 (E. coli) (predicted)	RGD1310562_predicted	similar to putative DNA glycosylase (predicted)	Symbol and Name updated	1299863	APPROVED
2005-01-20	RGD1310562_predicted	similar to putative DNA glycosylase (predicted)	LOC290729_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC290729_predicted	similar to putative DNA glycosylase (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)