Rab8a (RAB8A, member RAS oncogene family) - Rat Genome Database

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Gene: Rab8a (RAB8A, member RAS oncogene family) Rattus norvegicus
Analyze
Symbol: Rab8a
Name: RAB8A, member RAS oncogene family
RGD ID: 621144
Description: Enables protein tyrosine kinase binding activity. Involved in several processes, including cellular response to insulin stimulus; neurotransmitter receptor transport, endosome to postsynaptic membrane; and regulation of long-term neuronal synaptic plasticity. Located in several cellular components, including dendritic spine; neuronal cell body; and postsynaptic density. Is active in glutamatergic synapse. Colocalizes with Golgi apparatus. Orthologous to human RAB8A (RAB8A, member RAS oncogene family); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; Rab family mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Mel; mel transforming oncogene (derived from cell line NK14)- RAB8 homolog; MGC124948; Rab8; ras-related protein Rab-8A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21617,654,027 - 17,675,385 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1617,654,034 - 17,675,678 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1617,713,745 - 17,734,289 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01618,845,873 - 18,866,846 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01617,766,676 - 17,787,222 (-)NCBIRnor_WKY
Rnor_6.01619,355,047 - 19,376,776 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1619,355,048 - 19,376,776 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01619,213,378 - 19,235,107 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41618,078,519 - 18,099,882 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11618,079,199 - 18,089,589 (-)NCBI
Celera1617,868,660 - 17,890,021 (-)NCBICelera
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functional compartmentalization of endosomal trafficking for the synaptic delivery of AMPA receptors during long-term potentiation. Brown TC, etal., J Neurosci. 2007 Nov 28;27(48):13311-5.
2. Fer kinase/FerT and adherens junction dynamics in the testis: an in vitro and in vivo study. Chen YM, etal., Biol Reprod. 2003 Aug;69(2):656-72. Epub 2003 Apr 16.
3. Insulin and okadaic acid induce Rab4 redistribution in adipocytes. Cormont M, etal., J Biol Chem. 1993 Sep 15;268(26):19491-7.
4. rab15, a novel low molecular weight GTP-binding protein specifically expressed in rat brain. Elferink LA, etal., J Biol Chem 1992 Mar 25;267(9):5768-75.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Local control of AMPA receptor trafficking at the postsynaptic terminal by a small GTPase of the Rab family. Gerges NZ, etal., J Biol Chem. 2004 Oct 15;279(42):43870-8. Epub 2004 Aug 5.
7. Protein transport to the dendritic plasma membrane of cultured neurons is regulated by rab8p. Huber LA, etal., J Cell Biol. 1993 Oct;123(1):47-55.
8. Muscle cells engage Rab8A and myosin Vb in insulin-dependent GLUT4 translocation. Ishikura S and Klip A, Am J Physiol Cell Physiol. 2008 Oct;295(4):C1016-25. Epub 2008 Aug 13.
9. Rab proteins in endocytosis and Glut4 trafficking. Kaddai V, etal., Acta Physiol (Oxf). 2008 Jan;192(1):75-88.
10. The GLUT4 code. Larance M, etal., Mol Endocrinol. 2008 Feb;22(2):226-33. Epub 2007 Aug 23.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis. Sahlender DA, etal., J Cell Biol. 2005 Apr 25;169(2):285-95. Epub 2005 Apr 18.
15. Rab8A and Rab13 are activated by insulin and regulate GLUT4 translocation in muscle cells. Sun Y, etal., Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19909-14. doi: 10.1073/pnas.1009523107. Epub 2010 Nov 1.
16. Lgl1 activation of rab10 promotes axonal membrane trafficking underlying neuronal polarization. Wang T, etal., Dev Cell. 2011 Sep 13;21(3):431-44. doi: 10.1016/j.devcel.2011.07.007.
17. GLUT4 translocation: the last 200 nanometers. Watson RT and Pessin JE, Cell Signal. 2007 Nov;19(11):2209-17. Epub 2007 Jun 21.
18. Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Wilhelm BG, etal., Science. 2014 May 30;344(6187):1023-8. doi: 10.1126/science.1252884.
19. Insulin action on glucose transporters through molecular switches, tracks and tethers. Zaid H, etal., Biochem J. 2008 Jul 15;413(2):201-15.
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:16902405   PMID:17574030   PMID:17646400   PMID:17765678   PMID:18094055   PMID:18504258   PMID:19056867   PMID:19061864   PMID:19625297   PMID:19864458  
PMID:20458337   PMID:20592197   PMID:20937701   PMID:21255211   PMID:21844891   PMID:21951725   PMID:22159412   PMID:23389633   PMID:23979707   PMID:24006491   PMID:24421332   PMID:24469809  
PMID:24478457   PMID:24625528   PMID:24648492   PMID:24683533   PMID:24947469   PMID:27103069   PMID:28005071   PMID:30053369   PMID:36800997  


Genomics

Comparative Map Data
Rab8a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21617,654,027 - 17,675,385 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1617,654,034 - 17,675,678 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1617,713,745 - 17,734,289 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01618,845,873 - 18,866,846 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01617,766,676 - 17,787,222 (-)NCBIRnor_WKY
Rnor_6.01619,355,047 - 19,376,776 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1619,355,048 - 19,376,776 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01619,213,378 - 19,235,107 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41618,078,519 - 18,099,882 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11618,079,199 - 18,089,589 (-)NCBI
Celera1617,868,660 - 17,890,021 (-)NCBICelera
Cytogenetic Map16p14NCBI
RAB8A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381916,111,889 - 16,134,234 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1916,111,889 - 16,134,234 (+)EnsemblGRCh38hg38GRCh38
GRCh371916,222,699 - 16,245,044 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361916,083,490 - 16,105,445 (+)NCBINCBI36Build 36hg18NCBI36
Build 341916,083,489 - 16,105,443NCBI
Celera1916,124,417 - 16,146,398 (+)NCBICelera
Cytogenetic Map19p13.11NCBI
HuRef1915,793,443 - 15,815,391 (+)NCBIHuRef
CHM1_11916,221,978 - 16,243,940 (+)NCBICHM1_1
T2T-CHM13v2.01916,245,960 - 16,268,300 (+)NCBIT2T-CHM13v2.0
Rab8a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39872,915,044 - 72,935,210 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl872,915,044 - 72,937,748 (+)EnsemblGRCm39 Ensembl
GRCm38872,161,200 - 72,181,366 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl872,161,200 - 72,183,904 (+)EnsemblGRCm38mm10GRCm38
MGSCv37874,685,099 - 74,705,265 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36875,090,189 - 75,110,355 (+)NCBIMGSCv36mm8
Celera876,516,674 - 76,537,034 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.84NCBI
Rab8a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555241,403,811 - 1,416,005 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555241,403,811 - 1,416,005 (-)NCBIChiLan1.0ChiLan1.0
RAB8A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11919,985,674 - 20,007,842 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01915,598,029 - 15,619,988 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11916,580,720 - 16,602,189 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1916,580,720 - 16,602,189 (+)Ensemblpanpan1.1panPan2
RAB8A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12046,334,601 - 46,351,907 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2046,334,601 - 46,351,907 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2046,249,113 - 46,266,419 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02046,823,033 - 46,840,339 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2046,821,781 - 46,864,926 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12046,057,667 - 46,074,969 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02046,469,207 - 46,486,513 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02046,745,524 - 46,762,829 (-)NCBIUU_Cfam_GSD_1.0
Rab8a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118204,836,649 - 204,854,271 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365964,385,772 - 4,403,441 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365964,385,788 - 4,403,393 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAB8A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl261,429,523 - 61,450,413 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1261,430,680 - 61,450,351 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2261,176,944 - 61,196,619 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RAB8A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1614,611,938 - 14,634,086 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl614,611,868 - 14,634,487 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660744,859,385 - 4,881,900 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rab8a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249081,116,610 - 1,132,111 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249081,119,356 - 1,132,029 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rab8a
226 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:647
Count of miRNA genes:255
Interacting mature miRNAs:309
Transcripts:ENSRNOT00000020748
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
61372Bp40Blood pressure QTL 402.2blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)16422773017696785Rat
631517Scl9Serum cholesterol level QTL 93.3blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)161572643321034895Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 42 57 41 19 41 2 2 74 35 41 11 2
Low 1 6 9 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000020748   ⟹   ENSRNOP00000020748
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1617,655,142 - 17,675,399 (-)Ensembl
Rnor_6.0 Ensembl1619,355,048 - 19,376,776 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000077789   ⟹   ENSRNOP00000073296
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1617,654,034 - 17,675,399 (-)Ensembl
Rnor_6.0 Ensembl1619,355,730 - 19,366,485 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000094332   ⟹   ENSRNOP00000086633
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1617,654,034 - 17,675,678 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097895   ⟹   ENSRNOP00000084048
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1617,655,142 - 17,662,092 (-)Ensembl
RefSeq Acc Id: NM_053998   ⟹   NP_446450
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21617,654,027 - 17,675,385 (-)NCBI
Rnor_6.01619,355,047 - 19,376,776 (-)NCBI
Rnor_5.01619,213,378 - 19,235,107 (-)NCBI
RGSC_v3.41618,078,519 - 18,099,882 (-)RGD
Celera1617,868,660 - 17,890,021 (-)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_446450   ⟸   NM_053998
- UniProtKB: Q6DKL2 (UniProtKB/Swiss-Prot),   P35280 (UniProtKB/Swiss-Prot),   F8V328 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073296   ⟸   ENSRNOT00000077789
RefSeq Acc Id: ENSRNOP00000020748   ⟸   ENSRNOT00000020748
RefSeq Acc Id: ENSRNOP00000086633   ⟸   ENSRNOT00000094332
RefSeq Acc Id: ENSRNOP00000084048   ⟸   ENSRNOT00000097895

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35280-F1-model_v2 AlphaFold P35280 1-207 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699990
Promoter ID:EPDNEW_R10512
Type:multiple initiation site
Name:Rab8a_1
Description:RAB8A, member RAS oncogene family
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01619,376,784 - 19,376,844EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621144 AgrOrtholog
BioCyc Gene G2FUF-11874 BioCyc
Ensembl Genes ENSRNOG00000014621 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000020748.5 UniProtKB/TrEMBL
  ENSRNOP00000073296 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000073296.2 UniProtKB/Swiss-Prot
  ENSRNOP00000084048.1 UniProtKB/TrEMBL
  ENSRNOP00000086633.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020748.7 UniProtKB/TrEMBL
  ENSRNOT00000077789 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000077789.2 UniProtKB/Swiss-Prot
  ENSRNOT00000094332.1 UniProtKB/TrEMBL
  ENSRNOT00000097895.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7098881 IMAGE-MGC_LOAD
  IMAGE:7316419 IMAGE-MGC_LOAD
  IMAGE:7457017 IMAGE-MGC_LOAD
InterPro P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117103 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105355 IMAGE-MGC_LOAD
  MGC:124948 IMAGE-MGC_LOAD
  MGC:91545 IMAGE-MGC_LOAD
NCBI Gene 117103 ENTREZGENE
PANTHER LD44762P UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAS-RELATED PROTEIN RAB-8A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ras UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rab8a PhenoGen
PRINTS RASTRNSFRMNG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RAB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
SMART ARF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs small_GTP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K553_RAT UniProtKB/TrEMBL
  A0A8I5ZYA9_RAT UniProtKB/TrEMBL
  A0A8I6GF58_RAT UniProtKB/TrEMBL
  A0A8L2QAL6_RAT UniProtKB/TrEMBL
  F8V328 ENTREZGENE, UniProtKB/TrEMBL
  P35280 ENTREZGENE
  Q5M970_RAT UniProtKB/TrEMBL
  Q6DKL2 ENTREZGENE
  RAB8A_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q3B8Q4 UniProtKB/Swiss-Prot
  Q6DKL2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Rab8a  RAB8A, member RAS oncogene family  Mel  mel transforming oncogene (derived from cell line NK14)- RAB8 homolog  Symbol and Name updated 1299863 APPROVED
2002-08-07 Mel  mel transforming oncogene (derived from cell line NK14)- RAB8 homolog      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in spinal cord, heart, kidney, liver, and lung 633184