Bpifa5 (BPI fold containing family A, member 5) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Bpifa5 (BPI fold containing family A, member 5) Rattus norvegicus
Analyze
Symbol: Bpifa5
Name: BPI fold containing family A, member 5
RGD ID: 1559748
Description: Predicted to enable lipid binding activity. Predicted to be involved in several processes, including defense response to symbiont; negative regulation of single-species biofilm formation in or on host organism; and surfactant homeostasis. Predicted to be active in extracellular space. Orthologous to several human genes including BPIFA1 (BPI fold containing family A member 1); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; Cuprizon.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC311559; palate lung and nasal carcinoma-like protein; RGD1559748; similar to Palate lung and nasal carcinoma-like protein precursor (Tongue plunc-like protein); similar to Palate lung and nasal carcinoma-like protein precursor (Tongue plunc-like protein) (TPL); Splunc5
RGD Orthologs
Human
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83163,106,258 - 163,113,039 (+)NCBIGRCr8
mRatBN7.23142,646,103 - 142,652,884 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3142,646,103 - 142,652,883 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3146,547,997 - 146,554,773 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03155,131,835 - 155,138,615 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03152,872,071 - 152,878,853 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03149,643,481 - 149,649,398 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3149,643,481 - 149,649,398 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03156,021,054 - 156,026,972 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43144,548,148 - 144,554,452 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3141,387,519 - 141,393,811 (+)NCBICelera
Cytogenetic Map3q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14739326   PMID:15028288   PMID:21787333  


Genomics

Comparative Map Data
Bpifa5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83163,106,258 - 163,113,039 (+)NCBIGRCr8
mRatBN7.23142,646,103 - 142,652,884 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3142,646,103 - 142,652,883 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3146,547,997 - 146,554,773 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03155,131,835 - 155,138,615 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03152,872,071 - 152,878,853 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03149,643,481 - 149,649,398 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3149,643,481 - 149,649,398 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03156,021,054 - 156,026,972 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43144,548,148 - 144,554,452 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3141,387,519 - 141,393,811 (+)NCBICelera
Cytogenetic Map3q41NCBI
BPIFA4P
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382033,193,605 - 33,210,462 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2033,193,585 - 33,210,462 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p14 Ensembl2033,198,212 - 33,207,741 (+)EnsemblGRCh38hg38GRCh38
GRCh372031,781,411 - 31,798,268 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362031,249,679 - 31,259,208 (+)NCBINCBI36Build 36hg18NCBI36
Celera2028,535,301 - 28,552,159 (+)NCBICelera
Cytogenetic Map20q11.21NCBI
HuRef2028,569,010 - 28,585,865 (+)NCBIHuRef
CHM1_12031,682,520 - 31,699,378 (+)NCBICHM1_1
T2T-CHM13v2.02034,920,837 - 34,937,697 (+)NCBIT2T-CHM13v2.0
Bpifa5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392154,004,527 - 154,010,366 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2154,004,527 - 154,010,370 (+)EnsemblGRCm39 Ensembl
GRCm382154,162,607 - 154,168,446 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2154,162,607 - 154,168,450 (+)EnsemblGRCm38mm10GRCm38
MGSCv372153,988,343 - 153,994,182 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362153,854,047 - 153,859,884 (+)NCBIMGSCv36mm8
Celera2160,084,972 - 160,090,816 (+)NCBICelera
Cytogenetic Map2H1NCBI
cM Map276.19NCBI

Variants

.
Variants in Bpifa5
29 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:147
Count of miRNA genes:109
Interacting mature miRNAs:114
Transcripts:ENSRNOT00000020713
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141339236155617360Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141339013162184794Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3121056165145956249Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3140069424146976080Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat

Markers in Region
RH133595  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map31280.4UniSTS
Cytogenetic Map3q41UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
2 4 48 18 31 6 9 6 21 13 48 27 25

Sequence


Ensembl Acc Id: ENSRNOT00000020713   ⟹   ENSRNOP00000020713
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3142,646,103 - 142,652,883 (+)Ensembl
Rnor_6.0 Ensembl3149,643,481 - 149,649,398 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104063   ⟹   ENSRNOP00000093753
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3142,646,821 - 142,652,883 (+)Ensembl
RefSeq Acc Id: NM_001107792   ⟹   NP_001101262
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83163,106,258 - 163,113,038 (+)NCBI
mRatBN7.23142,646,103 - 142,652,883 (+)NCBI
Rnor_6.03149,643,481 - 149,649,398 (+)NCBI
Rnor_5.03156,021,054 - 156,026,972 (+)NCBI
RGSC_v3.43144,548,148 - 144,554,452 (+)RGD
Celera3141,387,519 - 141,393,811 (+)RGD
Sequence:
RefSeq Acc Id: XM_039105071   ⟹   XP_038960999
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83163,106,883 - 163,113,039 (+)NCBI
mRatBN7.23142,646,855 - 142,652,884 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001101262 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960999 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL85977 (Get FASTA)   NCBI Sequence Viewer  
  EDL85978 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000020713.4
  ENSRNOP00000093753.1
RefSeq Acc Id: NP_001101262   ⟸   NM_001107792
- Peptide Label: precursor
- UniProtKB: D3ZWC2 (UniProtKB/TrEMBL),   A6KHX7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000020713   ⟸   ENSRNOT00000020713
RefSeq Acc Id: XP_038960999   ⟸   XM_039105071
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AKM9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000093753   ⟸   ENSRNOT00000104063
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZWC2-F1-model_v2 AlphaFold D3ZWC2 1-270 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1559748 AgrOrtholog
BioCyc Gene G2FUF-47188 BioCyc
Ensembl Genes ENSRNOG00000013908 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020713.5 UniProtKB/TrEMBL
  ENSRNOT00000104063.1 UniProtKB/TrEMBL
InterPro Bactericidal_perm-incr_a/b_dom UniProtKB/TrEMBL
  BPI_fold-superfamily_member UniProtKB/TrEMBL
  Lipid-bd_serum_glycop_N UniProtKB/TrEMBL
KEGG Report rno:311559 UniProtKB/TrEMBL
NCBI Gene 311559 ENTREZGENE
PANTHER BPI FOLD-CONTAINING FAMILY A MEMBER 1 UniProtKB/TrEMBL
  BPI FOLD-CONTAINING FAMILY A MEMBER 5 UniProtKB/TrEMBL
Pfam LBP_BPI_CETP UniProtKB/TrEMBL
PhenoGen Bpifa5 PhenoGen
RatGTEx ENSRNOG00000013908 RatGTEx
Superfamily-SCOP Bactericidal_perm-incr_a/b_dom UniProtKB/TrEMBL
UniProt A0A8I6AKM9 ENTREZGENE, UniProtKB/TrEMBL
  A6KHX7 ENTREZGENE, UniProtKB/TrEMBL
  D3ZWC2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-01 Bpifa5  BPI fold containing family A, member 5  RGD1559748  similar to Palate lung and nasal carcinoma-like protein precursor (Tongue plunc-like protein)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1559748  similar to Palate lung and nasal carcinoma-like protein precursor (Tongue plunc-like protein)   RGD1559748_predicted  similar to Palate lung and nasal carcinoma-like protein precursor (Tongue plunc-like protein) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-10 RGD1559748_predicted  similar to Palate lung and nasal carcinoma-like protein precursor (Tongue plunc-like protein) (predicted)    similar to Palate lung and nasal carcinoma-like protein precursor (Tongue plunc-like protein) (TPL) (predicted)  Name updated 1299863 APPROVED
2006-03-07 RGD1559748_predicted  similar to Palate lung and nasal carcinoma-like protein precursor (Tongue plunc-like protein) (TPL) (predicted)  LOC311559  similar to Palate lung and nasal carcinoma-like protein precursor (Tongue plunc-like protein) (TPL)  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC311559  similar to Palate lung and nasal carcinoma-like protein precursor (Tongue plunc-like protein) (TPL)      Symbol and Name status set to provisional 70820 PROVISIONAL