Gpr65 (G-protein coupled receptor 65) - Rat Genome Database

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Gene: Gpr65 (G-protein coupled receptor 65) Rattus norvegicus
Analyze
Symbol: Gpr65
Name: G-protein coupled receptor 65
RGD ID: 1311832
Description: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in several processes, including activation of GTPase activity; positive regulation of stress fiber assembly; and response to acidic pH. Predicted to be active in plasma membrane. Orthologous to human GPR65 (G protein-coupled receptor 65); INTERACTS WITH acetamide; alpha-Zearalanol; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC299242; psychosine receptor; T cell death associated protein 8; Tdag8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86123,245,534 - 123,262,758 (+)NCBIGRCr8
mRatBN7.26117,515,786 - 117,536,514 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6117,515,648 - 117,536,512 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6117,684,709 - 117,685,722 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06117,981,508 - 117,982,521 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06117,316,387 - 117,317,400 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06122,248,528 - 122,256,115 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6122,254,841 - 122,256,251 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06131,454,591 - 131,471,218 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46122,432,615 - 122,433,628 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16122,436,361 - 122,453,748 (+)NCBI
Celera6115,094,236 - 115,095,249 (+)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
plasma membrane  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15618224   PMID:19501050   PMID:28365474  


Genomics

Comparative Map Data
Gpr65
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86123,245,534 - 123,262,758 (+)NCBIGRCr8
mRatBN7.26117,515,786 - 117,536,514 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6117,515,648 - 117,536,512 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6117,684,709 - 117,685,722 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06117,981,508 - 117,982,521 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06117,316,387 - 117,317,400 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06122,248,528 - 122,256,115 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6122,254,841 - 122,256,251 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06131,454,591 - 131,471,218 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46122,432,615 - 122,433,628 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16122,436,361 - 122,453,748 (+)NCBI
Celera6115,094,236 - 115,095,249 (+)NCBICelera
Cytogenetic Map6q32NCBI
GPR65
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381488,005,135 - 88,014,811 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1488,005,135 - 88,014,811 (+)EnsemblGRCh38hg38GRCh38
GRCh371488,471,479 - 88,481,155 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361487,541,249 - 87,548,168 (+)NCBINCBI36Build 36hg18NCBI36
Build 341487,541,248 - 87,548,167NCBI
Celera1468,517,156 - 68,526,848 (+)NCBICelera
Cytogenetic Map14q31.3NCBI
HuRef1468,641,596 - 68,651,288 (+)NCBIHuRef
CHM1_11488,409,597 - 88,419,284 (+)NCBICHM1_1
T2T-CHM13v2.01482,225,763 - 82,235,439 (+)NCBIT2T-CHM13v2.0
Gpr65
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391298,234,894 - 98,242,981 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1298,234,894 - 98,242,903 (+)EnsemblGRCm39 Ensembl
GRCm381298,268,635 - 98,276,722 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1298,268,635 - 98,276,644 (+)EnsemblGRCm38mm10GRCm38
MGSCv371299,506,867 - 99,514,842 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361298,669,707 - 98,677,682 (+)NCBIMGSCv36mm8
Celera1299,494,305 - 99,502,244 (+)NCBICelera
Cytogenetic Map12ENCBI
cM Map1249.84NCBI
Gpr65
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543810,729,659 - 10,730,660 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543810,724,069 - 10,730,868 (+)NCBIChiLan1.0ChiLan1.0
GPR65
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21589,149,357 - 89,153,296 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11488,365,863 - 88,369,802 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01468,617,219 - 68,624,158 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11487,977,315 - 87,984,261 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1487,983,034 - 87,984,047 (+)Ensemblpanpan1.1panPan2
GPR65
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1859,334,544 - 59,351,039 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl859,349,839 - 59,350,864 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha858,912,864 - 58,929,346 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0859,607,011 - 59,616,667 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1859,280,991 - 59,297,479 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0859,327,401 - 59,343,876 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0859,661,433 - 59,677,920 (+)NCBIUU_Cfam_GSD_1.0
Gpr65
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864016,523,596 - 16,530,390 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648815,544,149 - 15,545,156 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648815,544,075 - 15,545,344 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPR65
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7109,985,307 - 109,989,280 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17109,978,913 - 109,997,688 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27116,433,252 - 116,443,651 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GPR65
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12465,633,121 - 65,641,256 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2465,640,041 - 65,641,054 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605352,998,491 - 53,006,498 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpr65
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473414,333,151 - 14,334,155 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473414,332,974 - 14,339,786 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gpr65
129 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:22
Count of miRNA genes:22
Interacting mature miRNAs:22
Transcripts:ENSRNOT00000005055
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6104085867128713626Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6106752656132339866Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6112636280140994061Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6116506292130245370Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
1300076Glom8Glomerulus QTL 879e-09kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 37 87 87 86 55 25 55 6 197 83 67 42 53 31

Sequence


Ensembl Acc Id: ENSRNOT00000005055   ⟹   ENSRNOP00000005055
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl6122,254,841 - 122,256,251 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097200   ⟹   ENSRNOP00000078802
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6117,515,648 - 117,536,512 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112227   ⟹   ENSRNOP00000094255
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6117,515,648 - 117,536,512 (+)Ensembl
RefSeq Acc Id: NM_001106751   ⟹   NP_001100221
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86123,254,754 - 123,262,758 (+)NCBI
mRatBN7.26117,525,012 - 117,533,016 (+)NCBI
Rnor_6.06122,255,040 - 122,256,053 (+)NCBI
Rnor_5.06131,454,591 - 131,471,218 (+)NCBI
RGSC_v3.46122,432,615 - 122,433,628 (+)RGD
Celera6115,094,236 - 115,095,249 (+)RGD
Sequence:
RefSeq Acc Id: XM_008764761   ⟹   XP_008762983
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86123,245,786 - 123,262,741 (+)NCBI
mRatBN7.26117,515,921 - 117,536,514 (+)NCBI
Rnor_6.06122,248,528 - 122,256,115 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039112061   ⟹   XP_038967989
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86123,245,860 - 123,262,741 (+)NCBI
mRatBN7.26117,515,921 - 117,536,514 (+)NCBI
RefSeq Acc Id: XM_039112062   ⟹   XP_038967990
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86123,245,534 - 123,262,741 (+)NCBI
mRatBN7.26117,515,786 - 117,536,514 (+)NCBI
RefSeq Acc Id: XM_039112063   ⟹   XP_038967991
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86123,250,127 - 123,262,741 (+)NCBI
mRatBN7.26117,520,916 - 117,536,514 (+)NCBI
RefSeq Acc Id: NP_001100221   ⟸   NM_001106751
- UniProtKB: B0YIR8 (UniProtKB/TrEMBL),   A0A8I6AHC6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008762983   ⟸   XM_008764761
- Peptide Label: isoform X1
- UniProtKB: B0YIR8 (UniProtKB/TrEMBL),   A0A8I6AHC6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005055   ⟸   ENSRNOT00000005055
RefSeq Acc Id: XP_038967990   ⟸   XM_039112062
- Peptide Label: isoform X1
- UniProtKB: B0YIR8 (UniProtKB/TrEMBL),   A0A8I6AHC6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967989   ⟸   XM_039112061
- Peptide Label: isoform X1
- UniProtKB: B0YIR8 (UniProtKB/TrEMBL),   A0A8I6AHC6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967991   ⟸   XM_039112063
- Peptide Label: isoform X1
- UniProtKB: B0YIR8 (UniProtKB/TrEMBL),   A0A8I6AHC6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000094255   ⟸   ENSRNOT00000112227
Ensembl Acc Id: ENSRNOP00000078802   ⟸   ENSRNOT00000097200
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B0YIR8-F1-model_v2 AlphaFold B0YIR8 1-337 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311832 AgrOrtholog
BioCyc Gene G2FUF-36542 BioCyc
Ensembl Genes ENSRNOG00000003806 Ensembl
  ENSRNOG00000065590 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000097200.1 UniProtKB/TrEMBL
  ENSRNOT00000112227.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
  Psych_rcpt UniProtKB/TrEMBL
KEGG Report rno:299242 UniProtKB/TrEMBL
NCBI Gene 299242 ENTREZGENE
PANTHER G PROTEIN-COUPLED RECEPTOR 65 UniProtKB/TrEMBL
  LYSOPHOSPHATIDIC ACID RECEPTOR 5/SPHINGOSYLPHOSPHORYLCHOLINE RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PhenoGen Gpr65 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  PSYCHOSINER UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003806 RatGTEx
  ENSRNOG00000065590 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A8I6AHC6 ENTREZGENE, UniProtKB/TrEMBL
  B0YIR8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Gpr65  G-protein coupled receptor 65   Gpr65_predicted  G-protein coupled receptor 65 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Gpr65_predicted  G-protein coupled receptor 65 (predicted)      Symbol and Name status set to approved 70820 APPROVED