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Gene: Blk (BLK proto-oncogene, Src family tyrosine kinase) Rattus norvegicus
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Symbol: Blk
Name: BLK proto-oncogene, Src family tyrosine kinase
Description: Predicted to have non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; peptidyl-tyrosine autophosphorylation; and positive regulation of insulin secretion. Predicted to localize to the extrinsic component of cytoplasmic side of plasma membrane. Human ortholog(s) of this gene implicated in maturity-onset diabetes of the young type 11 and systemic lupus erythematosus. Orthologous to human BLK (BLK proto-oncogene, Src family tyrosine kinase); PARTICIPATES IN eicosanoid signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; glypican signaling pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; decabromodiphenyl ether; graphite.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: B lymphoid kinase; B lymphoid tyrosine kinase; LOC364403; MGC112647; tyrosine-protein kinase Blk
Orthologs:
Homo sapiens (human) : BLK (BLK proto-oncogene, Src family tyrosine kinase)  HGNC  Alliance
Mus musculus (house mouse) : Blk (B lymphoid kinase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Blk (BLK proto-oncogene, Src family tyrosine kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : BLK (BLK proto-oncogene, Src family tyrosine kinase)
Canis lupus familiaris (dog) : BLK (BLK proto-oncogene, Src family tyrosine kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Blk (BLK proto-oncogene, Src family tyrosine kinase)
Sus scrofa (pig) : BLK (BLK proto-oncogene, Src family tyrosine kinase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01546,555,552 - 46,593,778 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01550,317,854 - 50,355,753 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41542,643,847 - 42,682,793 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11542,659,818 - 42,698,493 (-)NCBI
Celera1537,310,648 - 37,348,449 (-)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Blk
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1308859
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.