Blk (BLK proto-oncogene, Src family tyrosine kinase) - Rat Genome Database

Blk (BLK proto-oncogene, Src family tyrosine kinase) - Rat Genome Database

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Gene: Blk (BLK proto-oncogene, Src family tyrosine kinase) Rattus norvegicus

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Symbol:

Blk

Name:

BLK proto-oncogene, Src family tyrosine kinase

RGD ID:

1308859

Description:

Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; peptidyl-tyrosine phosphorylation; and positive regulation of insulin secretion. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in maturity-onset diabetes of the young type 11 and systemic lupus erythematosus. Orthologous to human BLK (BLK proto-oncogene, Src family tyrosine kinase); PARTICIPATES IN eicosanoid signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; glypican signaling pathway; INTERACTS WITH aflatoxin B1; alpha-Zearalanol; decabromodiphenyl ether.

Type:

protein-coding

RefSeq Status:

Previously known as:

B lymphoid kinase; B lymphoid tyrosine kinase; LOC364403; MGC112647; tyrosine-protein kinase Blk

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	41,802,701 - 41,841,004 (-)	NCBI		GRCr8
mRatBN7.2	15	37,626,746 - 37,665,053 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	37,627,039 - 37,665,031 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	39,479,764 - 39,517,808 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	40,630,559 - 40,668,609 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	39,087,624 - 39,125,646 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	46,555,552 - 46,593,778 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	46,555,188 - 46,593,653 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	50,317,854 - 50,355,753 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	42,643,847 - 42,682,793 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	42,659,818 - 42,698,493 (-)	NCBI
Celera	15	37,310,648 - 37,348,449 (-)	NCBI		Celera
Cytogenetic Map	15	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Blk	Rat	Myocardial Reperfusion Injury		IEP		1642307	mRNA:increased expression:left ventricle (rat)	RGD
Blk	Rat	systemic lupus erythematosus		ISO	BLK (Homo sapiens)	2316189	DNA:snp:promoter:rs13277113 (human)	RGD

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Blk	Rat	Atrioventricular Septal Defect 4		ISO	BLK (Homo sapiens)	8554872	ClinVar Annotator: match by term: Atrioventricular septal defect 4	ClinVar	PMID:19353638 more ...
Blk	Rat	diabetes mellitus		ISO	BLK (Homo sapiens)	8554872	ClinVar Annotator: match by term: Monogenic diabetes	ClinVar	PMID:18204098 more ...
Blk	Rat	maturity-onset diabetes of the young		ISO	BLK (Homo sapiens)	8554872	ClinVar Annotator: match by term: Maturity onset diabetes mellitus in young	ClinVar
Blk	Rat	maturity-onset diabetes of the young		ISO	BLK (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:25741868
Blk	Rat	maturity-onset diabetes of the young type 11		ISO	BLK (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:18204098 more ...
Blk	Rat	Neurodevelopmental Disorders		ISO	BLK (Homo sapiens)	8554872	ClinVar Annotator: match by term: Neurodevelopmental disorder	ClinVar	PMID:25741868
Blk	Rat	systemic lupus erythematosus		ISO	BLK (Homo sapiens)	8554872	ClinVar Annotator: match by term: Systemic lupus erythematosus	ClinVar	PMID:18204098 more ...
Blk	Rat	thoracic aortic aneurysm		ISO	BLK (Homo sapiens)	8554872	ClinVar Annotator: match by term: Thoracic aortic aneurysm	ClinVar	PMID:32748548

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Blk	Rat	Kawasaki disease		ISO	BLK (Homo sapiens)	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:22446961
Blk	Rat	rheumatoid arthritis		ISO	BLK (Homo sapiens)	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:20453842 and PMID:23143596
Blk	Rat	systemic lupus erythematosus		ISO	BLK (Homo sapiens)	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:19838193

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Blk	Rat	maturity-onset diabetes of the young type 11		ISO	BLK (Homo sapiens)	7240710		OMIM

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Blk	Rat	2,3,7,8-tetrachlorodibenzodioxine	increases expression	ISO	Blk (Mus musculus)	6480464	Tetrachlorodibenzodioxin results in increased expression of BLK mRNA	CTD	PMID:20819909
Blk	Rat	2,3,7,8-tetrachlorodibenzodioxine	multiple interactions	ISO	Blk (Mus musculus)	6480464	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to BLK gene]	CTD	PMID:20819909
Blk	Rat	afimoxifene	decreases response to substance	ISO	BLK (Homo sapiens)	6480464	BLK results in decreased susceptibility to afimoxifene	CTD	PMID:21233418
Blk	Rat	aflatoxin B1	increases methylation	ISO	BLK (Homo sapiens)	6480464	Aflatoxin B1 results in increased methylation of BLK gene	CTD	PMID:27153756
Blk	Rat	aflatoxin B1	decreases expression	EXP		6480464	Aflatoxin B1 results in decreased expression of BLK mRNA	CTD	PMID:33354967
Blk	Rat	all-trans-retinoic acid	decreases expression	ISO	Blk (Mus musculus)	6480464	Tretinoin results in decreased expression of BLK mRNA	CTD	PMID:36189433
Blk	Rat	all-trans-retinoic acid	multiple interactions	ISO	Blk (Mus musculus)	6480464	[mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in decreased expression of BLK mRNA	CTD	PMID:36189433
Blk	Rat	alpha-Zearalanol	increases expression	EXP		6480464	Zeranol results in increased expression of BLK mRNA	CTD	PMID:35163327
Blk	Rat	arsane	multiple interactions	ISO	BLK (Homo sapiens)	6480464	[Arsenic co-treated with Fluorides] results in decreased expression of BLK mRNA	CTD	PMID:19962721
Blk	Rat	arsenic atom	multiple interactions	ISO	BLK (Homo sapiens)	6480464	[Arsenic co-treated with Fluorides] results in decreased expression of BLK mRNA	CTD	PMID:19962721
Blk	Rat	benzo[a]pyrene	decreases expression	ISO	Blk (Mus musculus)	6480464	Benzo(a)pyrene results in decreased expression of BLK mRNA	CTD	PMID:21569818
Blk	Rat	benzo[a]pyrene	increases methylation	ISO	BLK (Homo sapiens)	6480464	Benzo(a)pyrene results in increased methylation of BLK 5' UTR and Benzo(a)pyrene results in increased methylation of BLK promoter	CTD	PMID:27901495
Blk	Rat	benzo[e]pyrene	decreases methylation	ISO	BLK (Homo sapiens)	6480464	benzo(e)pyrene results in decreased methylation of BLK exon	CTD	PMID:30157460
Blk	Rat	bisphenol A	increases expression	ISO	Blk (Mus musculus)	6480464	bisphenol A results in increased expression of BLK mRNA	CTD	PMID:32156529 and PMID:38701888
Blk	Rat	bortezomib	decreases expression	ISO	BLK (Homo sapiens)	6480464	Bortezomib results in decreased expression of BLK mRNA	CTD	PMID:20977926
Blk	Rat	buta-1,3-diene	decreases expression	ISO	Blk (Mus musculus)	6480464	1 and 3-butadiene results in decreased expression of BLK mRNA	CTD	PMID:29038090
Blk	Rat	carmustine	decreases expression	ISO	BLK (Homo sapiens)	6480464	Carmustine results in decreased expression of BLK mRNA	CTD	PMID:15980968
Blk	Rat	CGP 52608	multiple interactions	ISO	BLK (Homo sapiens)	6480464	CGP 52608 promotes the reaction [RORA protein binds to BLK gene]	CTD	PMID:28238834
Blk	Rat	chloroprene	decreases expression	ISO	Blk (Mus musculus)	6480464	Chloroprene results in decreased expression of BLK mRNA	CTD	PMID:23125180
Blk	Rat	decabromodiphenyl ether	increases expression	EXP		6480464	decabromobiphenyl ether results in increased expression of BLK mRNA	CTD	PMID:23640034
Blk	Rat	dexamethasone phosphate	multiple interactions	EXP		6480464	dexamethasone 21-phosphate inhibits the reaction [Lipopolysaccharides results in increased expression of BLK mRNA]	CTD	PMID:36996615
Blk	Rat	dimethylarsinic acid	multiple interactions	ISO	Blk (Mus musculus)	6480464	[sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of BLK mRNA	CTD	PMID:34876320
Blk	Rat	dioxygen	multiple interactions	ISO	Blk (Mus musculus)	6480464	[NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of BLK mRNA	CTD	PMID:30529165
Blk	Rat	graphite	affects expression	EXP		6480464	Graphite affects the expression of BLK mRNA	CTD	PMID:29933104
Blk	Rat	isoflurane	decreases expression	EXP		6480464	Isoflurane results in decreased expression of BLK mRNA	CTD	PMID:16978161
Blk	Rat	lidocaine	increases expression	EXP		6480464	Lidocaine results in increased expression of BLK mRNA	CTD	PMID:35283115
Blk	Rat	lipopolysaccharide	multiple interactions	EXP		6480464	dexamethasone 21-phosphate inhibits the reaction [Lipopolysaccharides results in increased expression of BLK mRNA]	CTD	PMID:36996615
Blk	Rat	lipopolysaccharide	increases expression	EXP		6480464	Lipopolysaccharides results in increased expression of BLK mRNA	CTD	PMID:36996615
Blk	Rat	methapyrilene	decreases methylation	ISO	BLK (Homo sapiens)	6480464	Methapyrilene results in decreased methylation of BLK exon	CTD	PMID:30157460
Blk	Rat	methylarsonic acid	multiple interactions	ISO	Blk (Mus musculus)	6480464	[sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of BLK mRNA	CTD	PMID:34876320
Blk	Rat	microcystin-LR	multiple interactions	ISO	BLK (Homo sapiens)	6480464	BLK protein inhibits the reaction [cyanoginosin LR affects the localization of CGAS protein] more ...	CTD	PMID:36435412
Blk	Rat	mono(2-ethylhexyl) phthalate	multiple interactions	ISO	Blk (Mus musculus)	6480464	[mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in decreased expression of BLK mRNA	CTD	PMID:36189433
Blk	Rat	nitrates	multiple interactions	ISO	Blk (Mus musculus)	6480464	[Particulate Matter results in increased abundance of Nitrates] which results in increased expression of BLK mRNA	CTD	PMID:35964746
Blk	Rat	oxaliplatin	multiple interactions	EXP		6480464	[oxaliplatin co-treated with Topotecan] results in decreased expression of BLK mRNA	CTD	PMID:25729387
Blk	Rat	ozone	multiple interactions	ISO	Blk (Mus musculus)	6480464	[Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of BLK mRNA and [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of BLK mRNA	CTD	PMID:34911549
Blk	Rat	p-menthan-3-ol	decreases expression	ISO	BLK (Homo sapiens)	6480464	Menthol results in decreased expression of BLK mRNA	CTD	PMID:26760959
Blk	Rat	paracetamol	decreases expression	ISO	BLK (Homo sapiens)	6480464	Acetaminophen results in decreased expression of BLK mRNA	CTD	PMID:22230336
Blk	Rat	paraquat	decreases expression	EXP		6480464	Paraquat results in decreased expression of BLK mRNA	CTD	PMID:32680482
Blk	Rat	pentobarbital	decreases expression	EXP		6480464	Pentobarbital results in decreased expression of BLK mRNA	CTD	PMID:16978161
Blk	Rat	pirinixic acid	multiple interactions	ISO	Blk (Mus musculus)	6480464	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of BLK mRNA	CTD	PMID:19710929
Blk	Rat	ponatinib	decreases activity	ISO	BLK (Homo sapiens)	6480464	ponatinib results in decreased activity of BLK protein	CTD	PMID:19878872
Blk	Rat	SB 431542	increases expression	ISO	BLK (Homo sapiens)	6480464	4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of BLK protein	CTD	PMID:25670856
Blk	Rat	sodium arsenate	multiple interactions	ISO	Blk (Mus musculus)	6480464	[sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of BLK mRNA	CTD	PMID:34876320
Blk	Rat	sodium arsenite	multiple interactions	ISO	Blk (Mus musculus)	6480464	[sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of BLK mRNA	CTD	PMID:34876320
Blk	Rat	temozolomide	decreases expression	ISO	BLK (Homo sapiens)	6480464	Temozolomide results in decreased expression of BLK mRNA	CTD	PMID:31758290
Blk	Rat	testosterone	decreases expression	ISO	BLK (Homo sapiens)	6480464	Testosterone results in decreased expression of BLK mRNA	CTD	PMID:33359661
Blk	Rat	thioacetamide	decreases expression	EXP		6480464	Thioacetamide results in decreased expression of BLK mRNA	CTD	PMID:34492290
Blk	Rat	thiram	increases expression	ISO	BLK (Homo sapiens)	6480464	Thiram results in increased expression of BLK mRNA	CTD	PMID:38568856
Blk	Rat	topotecan	multiple interactions	EXP		6480464	[oxaliplatin co-treated with Topotecan] results in decreased expression of BLK mRNA	CTD	PMID:25729387
Blk	Rat	trichloroethene	decreases expression	EXP		6480464	Trichloroethylene results in decreased expression of BLK mRNA	CTD	PMID:33387578
Blk	Rat	trimellitic anhydride	increases expression	ISO	Blk (Mus musculus)	6480464	trimellitic anhydride results in increased expression of BLK mRNA	CTD	PMID:19042947
Blk	Rat	triphenyl phosphate	affects expression	ISO	BLK (Homo sapiens)	6480464	triphenyl phosphate affects the expression of BLK mRNA	CTD	PMID:37042841
Blk	Rat	valproic acid	affects expression	ISO	Blk (Mus musculus)	6480464	Valproic Acid affects the expression of BLK mRNA	CTD	PMID:17292431
Blk	Rat	zinc atom	increases expression	ISO	BLK (Homo sapiens)	6480464	Zinc results in increased expression of BLK mRNA	CTD	PMID:15226459
Blk	Rat	zinc sulfate	increases expression	ISO	BLK (Homo sapiens)	6480464	Zinc Sulfate results in increased expression of BLK mRNA	CTD	PMID:15226459
Blk	Rat	zinc(0)	increases expression	ISO	BLK (Homo sapiens)	6480464	Zinc results in increased expression of BLK mRNA	CTD	PMID:15226459

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Blk	Rat	B cell receptor signaling pathway	involved_in	ISO	BLK (Homo sapiens)	1624291	UniProtKB:Q8NDB2 more ...	RGD	PMID:23555801 and PMID:876631
Blk	Rat	B cell receptor signaling pathway	involved_in	IEA	UniProtKB:P51451 and ensembl:ENSP00000259089	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Blk	Rat	biological_process		ND		1598407	01/2010: no relevant rat data	RGD
Blk	Rat	cell differentiation	involved_in	IBA	FB:FBgn0262733 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Blk	Rat	cell surface receptor protein tyrosine kinase signaling pathway	involved_in	IBA	PANTHER:PTN002521528 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Blk	Rat	peptidyl-tyrosine phosphorylation	involved_in	ISO	BLK (Homo sapiens)	1624291	PMID:30356214	RGD	PMID:30356214
Blk	Rat	positive regulation of insulin secretion	involved_in	ISO	BLK (Homo sapiens)	1624291	PMID:19667185	RGD	PMID:19667185
Blk	Rat	positive regulation of insulin secretion	involved_in	IEA	UniProtKB:P51451 and ensembl:ENSP00000259089	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Blk	Rat	plasma membrane	is_active_in	IBA	FB:FBgn0000017 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Blk	Rat	ATP binding	enables	IEA	UniRule:UR001503341	1600115	GO_REF:0000104	UniProt	GO_REF:0000104
Blk	Rat	ATP binding	enables	IEA	UniProtKB-KW:KW-0067	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Blk	Rat	ATP binding	enables	IEA	InterPro:IPR000719 and InterPro:IPR017441	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Blk	Rat	kinase activity	enables	IEA	UniProtKB-KW:KW-0418	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Blk	Rat	non-membrane spanning protein tyrosine kinase activity	enables	ISO	BLK (Homo sapiens)	1624291	PMID:23555801 and PMID:876631	RGD	PMID:23555801 and PMID:876631
Blk	Rat	non-membrane spanning protein tyrosine kinase activity	enables	IEA	EC:2.7.10.2	1600115	GO_REF:0000003	UniProt	GO_REF:0000003
Blk	Rat	non-membrane spanning protein tyrosine kinase activity	enables	IBA	FB:FBgn0262733 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Blk	Rat	non-membrane spanning protein tyrosine kinase activity	enables	IEA	UniProtKB:P51451 and ensembl:ENSP00000259089	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Blk	Rat	nucleotide binding	enables	IEA	UniRule:UR001503341	1600115	GO_REF:0000104	UniProt	GO_REF:0000104
Blk	Rat	nucleotide binding	enables	IEA	UniProtKB-KW:KW-0547	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Blk	Rat	protein binding	enables	ISO	BLK (Homo sapiens)	1624291	UniProtKB:A0A0C4DGF1 more ...	RGD	PMID:16273093 more ...
Blk	Rat	protein binding	enables	ISO	Blk (Mus musculus)	1624291	PR:Q62018 PMID:8636124	RGD	PMID:8636124
Blk	Rat	protein kinase activity	enables	IEA	InterPro:IPR000719 and InterPro:IPR001245	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Blk	Rat	protein tyrosine kinase activity	enables	ISO	BLK (Homo sapiens)	1624291	PMID:30356214	RGD	PMID:30356214
Blk	Rat	protein tyrosine kinase activity	enables	IEA	InterPro:IPR020635	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Blk	Rat	protein tyrosine kinase activity	enables	IEA	UniProtKB-KW:KW-0829	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Blk	Rat	protein tyrosine kinase activity	enables	IEA	UniProtKB:P51451 and ensembl:ENSP00000259089	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Blk	Rat	signaling receptor binding	enables	IBA	FB:FBgn0262733 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Blk	Rat	transferase activity	enables	IEA	UniProtKB-KW:KW-0808	1600115	GO_REF:0000043	UniProt	GO_REF:0000043

Imported Annotations - PID (archival)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Blk	Rat	eicosanoid signaling pathway		ISO	BLK (Homo sapiens)	6484113		PID	PID:200082
Blk	Rat	ephrin - ephrin receptor bidirectional signaling axis		ISO	BLK (Homo sapiens)	6484113		PID	PID:200204
Blk	Rat	ephrin - ephrin receptor bidirectional signaling axis		ISO	BLK (Homo sapiens)	6484113		PID	PID:200142
Blk	Rat	glypican signaling pathway		ISO	BLK (Homo sapiens)	6484113		PID	PID:200026
Blk	Rat	phosphatidylinositol 3-kinase class I signaling pathway		ISO	BLK (Homo sapiens)	6484113		PID	PID:200116
Blk	Rat	platelet-derived growth factor signaling pathway		ISO	BLK (Homo sapiens)	6484113		PID	PID:200149

#	Reference Title	Reference Citation
1.	The effect of cardiac ischemic preconditioning on rat left ventricular gene expression profile.	Canatan H Cell Biochem Funct. 2007 Jun 11;.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Replication of the association between the C8orf13-BLK region and systemic lupus erythematosus in a Japanese population.	Ito I, etal., Arthritis Rheum. 2009 Feb;60(2):553-8.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
7.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8.	GOA pipeline	RGD automated data pipeline
9.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	Comprehensive gene review and curation	RGD comprehensive gene curation

PMID:876631	PMID:12477932	PMID:19667185	PMID:30356214

Blk
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	41,802,701 - 41,841,004 (-)	NCBI		GRCr8
mRatBN7.2	15	37,626,746 - 37,665,053 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	37,627,039 - 37,665,031 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	39,479,764 - 39,517,808 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	40,630,559 - 40,668,609 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	39,087,624 - 39,125,646 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	46,555,552 - 46,593,778 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	46,555,188 - 46,593,653 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	50,317,854 - 50,355,753 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	42,643,847 - 42,682,793 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	42,659,818 - 42,698,493 (-)	NCBI
Celera	15	37,310,648 - 37,348,449 (-)	NCBI		Celera
Cytogenetic Map	15	p12	NCBI

BLK
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	11,494,387 - 11,564,599 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	11,486,894 - 11,564,599 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	11,351,896 - 11,422,108 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	11,388,930 - 11,459,517 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	11,388,929 - 11,459,516	NCBI
Celera	8	10,480,897 - 10,551,454 (+)	NCBI		Celera
Cytogenetic Map	8	p23.1	NCBI
HuRef	8	10,282,885 - 10,353,426 (+)	NCBI		HuRef
CHM1_1	8	11,416,813 - 11,487,683 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	8	8,175,675 - 8,245,838 (-)	NCBI		T2T-CHM13v2.0

Blk
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	63,610,286 - 63,654,636 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	63,610,285 - 63,654,486 (-)	Ensembl		GRCm39 Ensembl
GRCm38	14	63,372,837 - 63,417,187 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	63,372,836 - 63,417,037 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	63,991,674 - 64,036,024 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	62,326,947 - 62,371,297 (-)	NCBI		MGSCv36	mm8
Celera	14	61,138,348 - 61,182,625 (-)	NCBI		Celera
Cytogenetic Map	14	D1	NCBI
cM Map	14	33.25	NCBI

Blk
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955403	52,832,604 - 52,874,264 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955403	52,825,397 - 52,874,007 (+)	NCBI	ChiLan1.0	ChiLan1.0

BLK
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	27,961,701 - 28,032,048 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	3,988,006 - 4,058,396 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	7,637,680 - 7,708,914 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

BLK
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	25	26,336,253 - 26,357,494 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	25	26,336,892 - 26,358,015 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	25	26,989,229 - 27,064,576 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	25	26,487,019 - 26,562,216 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	25	26,487,603 - 26,562,224 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	25	26,439,922 - 26,514,938 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	25	26,336,943 - 26,412,007 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	25	26,488,713 - 26,563,761 (-)	NCBI		UU_Cfam_GSD_1.0

Blk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404943	5,339,527 - 5,357,038 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936675	3,229,154 - 3,246,292 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936675	3,228,982 - 3,246,617 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

BLK
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	14,688,943 - 14,745,947 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	14,688,489 - 14,745,946 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	15,895,128 - 15,934,019 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

BLK
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	7,547,200 - 7,618,645 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	7,547,299 - 7,569,188 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666052	34,810,867 - 34,883,078 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Blk
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624758	25,129,853 - 25,181,761 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624758	25,129,922 - 25,180,180 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

.

Variants in Blk
225 total Variants

Predicted Target Of

	Summary Value
Count of predictions:	274
Count of miRNA genes:	180
Interacting mature miRNAs:	199
Transcripts:	ENSRNOT00000015021
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331729	Rf42	Renal function QTL 42	3.071		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	15	17362897	73690657	Rat
1641887	Alcrsp14	Alcohol response QTL 14			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	15	1	42356671	Rat
10755503	Bp391	Blood pressure QTL 391	2.37		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	15	20248600	37896129	Rat
1582227	Gluco30	Glucose level QTL 30	3.6	0.0003	blood glucose amount (VT:0000188)	absolute change in blood glucose level area under curve (CMO:0002034)	15	28030665	82262678	Rat
1582228	Epfw3	Epididymal fat weight QTL 3	4.1	0.0002	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	15	28030665	82262678	Rat
1578646	Bmd18	Bone mineral density QTL 18	5.2		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	15	22806240	98288169	Rat
1578647	Bmd17	Bone mineral density QTL 17	4		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	15	22806240	98288169	Rat
10401805	Kidm51	Kidney mass QTL 51			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	15	306329	45306329	Rat
2293686	Bmd36	Bone mineral density QTL 36	7.4	0.0001	femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	15	33611058	71477291	Rat
2317750	Glom26	Glomerulus QTL 26	4.3		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	15	12496141	65205939	Rat
2298549	Neuinf12	Neuroinflammation QTL 12	3.5		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	15	1	55302115	Rat
2293691	Bmd37	Bone mineral density QTL 37	6.6	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	15	33611058	71477291	Rat
2293688	Bss29	Bone structure and strength QTL 29	5.31	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	15	11111142	56111142	Rat
1582214	Stl21	Serum triglyceride level QTL 21	3.1	0.022	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	15	28030665	82262678	Rat
631273	Lecl2	Lens clarity QTL 2		0.001	lens clarity trait (VT:0001304)	age of onset/diagnosis of cataract (CMO:0001584)	15	10596089	55596089	Rat
2300167	Bmd63	Bone mineral density QTL 63	5.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	15	11111142	56111142	Rat
731170	Pur3	Proteinuria QTL 3	2.3	0.0005	urine protein amount (VT:0005160)	urine protein excretion rate (CMO:0000759)	15	1	41686771	Rat
738017	Hcas7	Hepatocarcinoma susceptibility QTL 7	2.91		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	15	2266368	46921453	Rat
152025253	Hrtrt24	Heart rate QTL 24	3.82		heart pumping trait (VT:2000009)		15	27885774	86257085	Rat
10054130	Srcrt8	Stress Responsive Cort QTL 8	2.18	0.0085	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	15	22117933	67117933	Rat
2300173	Bmd62	Bone mineral density QTL 62	12.8	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	15	11111142	56111142	Rat
2324620	Coatc3	Coat color QTL 3			coat/hair pigmentation trait (VT:0010463)	pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)	15	19856566	46187442	Rat
61424	Scl1	Serum cholesterol level QTL 1	7.7	0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	15	16725528	80672115	Rat
1582251	Gluco24	Glucose level QTL 24	3.2	0.0008	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	15	5530756	50530756	Rat
1598828	Glom14	Glomerulus QTL 14	2.5		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	15	34054139	79054139	Rat
1582242	Gluco28	Glucose level QTL 28	3.3	0.0008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	15	28030665	82262678	Rat
1578660	Bss19	Bone structure and strength QTL 19	4.3		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	15	22806240	98288169	Rat
1582244	Bw79	Body weight QTL 79	4	0.0002	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	15	28030665	82262678	Rat

D15Rat119

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	15	41,807,938 - 41,808,150 (+)	Marker Load Pipeline
mRatBN7.2	15	37,631,983 - 37,632,195 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	46,560,523 - 46,560,734	NCBI	Rnor6.0
Rnor_5.0	15	50,322,825 - 50,323,036	UniSTS	Rnor5.0
RGSC_v3.4	15	42,649,228 - 42,649,440	RGD	RGSC3.4
RGSC_v3.4	15	42,649,229 - 42,649,440	UniSTS	RGSC3.4
RGSC_v3.1	15	42,664,928 - 42,665,140	RGD
Celera	15	37,315,611 - 37,315,822	UniSTS
SHRSP x BN Map	15	32.3898	UniSTS
SHRSP x BN Map	15	32.3898	RGD
Cytogenetic Map	15	p12	UniSTS

RH131524

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	37,626,771 - 37,626,965 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	46,301,761 - 46,301,954	NCBI	Rnor6.0
Rnor_5.0	15	50,066,555 - 50,066,748	UniSTS	Rnor5.0
RGSC_v3.4	15	42,643,606 - 42,643,799	UniSTS	RGSC3.4
Celera	15	37,310,407 - 37,310,600	UniSTS
RH 3.4 Map	15	285.2	UniSTS
Cytogenetic Map	15	p12	UniSTS

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	45	76	87	86	55	25	55	6	194	91	56	31	54	31


RefSeq Transcripts	NM_001025751	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006252188	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008770770	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039093550	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC098683	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474023	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000015021 ⟹ ENSRNOP00000015021

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	37,627,039 - 37,665,031 (-)	Ensembl
Rnor_6.0 Ensembl	15	46,555,188 - 46,593,653 (-)	Ensembl

RefSeq Acc Id:

NM_001025751 ⟹ NP_001020922

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	41,802,968 - 41,840,982 (-)	NCBI
mRatBN7.2	15	37,627,013 - 37,665,031 (-)	NCBI
Rnor_6.0	15	46,555,552 - 46,593,570 (-)	NCBI
Rnor_5.0	15	50,317,854 - 50,355,753 (-)	NCBI
RGSC_v3.4	15	42,643,847 - 42,682,793 (-)	RGD
Celera	15	37,310,648 - 37,348,449 (-)	RGD

Sequence:

show sequence

GACCAGCATGGCTGAACGTCAGGTGCCCACGGAACTTCCTCAAGAGGATCTCTGGGGCTGAGGAGCCAGAATTCTCCAGAAGGCTTGGCTGGAGGGTGGAGCTCACGTTGAACTGCTTCTTGGGGCTT
TTGATGGAAGTCTGATCACAACGGGGGCACACACACCTCTGAATGCTGTTAGCAGGAAGCCACAAGCCACTGAAGCTGACTGAGATGAGAAGAATCCATCTGGGGATGGGATTGGTTTGTCGTAACTG
GGTCCAGAGCTTCTGGTTGCTGCTAGAAGATTCTTCAACCACATGCACCCTGGGATCTGAACAGCTATGTTGAAAGGCTACTGAAGCCCTGCAAGGATGGGGCTACTGAGCAGCAAGAGGCAGATCAG
CGAGAAGAGCAAGAGCTGGAGCCCTGTGAAGGCCCGCGCCCAGGGCAAGGTACCCCCGCCCCTGCCACCCCTGGTTGTCTTCAACCACCTCCCTCCTCCATCTCCTAACCAGCACCCAGATGAAGAGG
AGCGTTTTGTGGTGGCCCTGTTTGACTATGCCGCTGTGAATGACAGGGACCTGCAAGTGCTAAAGGGAGAGAAGCTCCAAGTCTTGAAGAGCACTGGAGACTGGTGGTTGGCCAGGTCACTCGTCACA
GGAAGAGAAGGCTATGTGCCCAGCAACTTTGTGGCCCCAGTAGAGACCCTGGAAGTAGAAAAATGGTTCTTCAGGACCATTAGCCGGAAGGATGCTGAGAGGCAGTTGCTGGCTCCAATGAACAAAGC
CGGCTCCTTTCTCATCAGAGAGAGTGAGAGCAATAAAGGTGCCTTTTCCCTATCTGTGAAAGACGTCACCAGCCAGGGGGAGATGGTCAAGCACTATAAGATCCGCTCACTGGACAATGGAGGCTATT
ACATCTCGCCCCGGATCACCTTCCCCACCCTCCAGGCCCTGGTGCAGCACTATTCTGAGAAAGGGGACGGTTTGTGTCAGAAGTTGACCCTGCCCTGTGTGAACCCAGCCCCGAAGAATCCCTGGGCC
CAAGACGAATGGGAAATCCCCAGGCAGTCCCTCAAGTTGGTCCGGAAACTTGGGTCTGGGCAGTTTGGTGAAGTCTGGATGGGTTATTACAAAAATAACATGAAGGTGGCAATCAAGACCCTGAAGGA
GGGAACCATGTCTCCGGAAGCTTTCCTGGGTGAGGCCAACGTGATGAAAACCCTGCAGCATGAGAGGCTGGTCCGTCTCTACGCCGTGGTCACCAGAGAGCCCATCTACATTGTCACGGAATACATGG
CCAGAGGATGCTTGCTGGATTTTCTGAAGACCGATGAAGGTAGCAGATTGTCCCTTCCAAGGCTGATTGACATGTCAGCCCAGGTTGCAGAAGGGATGGCTTACATAGAGCGCATGAATTCCATCCAC
CGTGACCTGCGGGCAGCCAACATCCTGGTGTCTGAGACCTTGTGCTGCAAAATCGCTGACTTCGGCTTGGCCAGGATCATCGACAGTGAATATACTGCCCAAGAGGGGGCCAAGTTCCCCATCAAGTG
GACTGCCCCAGAAGCCATCCACTTCGGGGTGTTTACCATCAAGGCTGATGTGTGGTCCTTTGGAGTCTTGCTGATGGAGATTGTCACATATGGGCGTGTTCCCTACCCAGGAATGAGCAACCCTGAGG
TCATCCGTAGCCTGGAGCATGGCTACCGAATGCCATGCCCAGAGACATGTCCGCCTGAGTTGTACCATGACGTCATCACTGAGTGCTGGCGAGGCCGACCTGAGGAGCGGCCTACCTTTGAGTTCCTG
CAGTCAGTGCTGGAGGACTTCTACACAGCCACGGAGGGCCAATATGAGCTGCAGCCTTAGCAGCAAATAGGCTCTTCAGTGTTCCCTGCCTGAGTCTCCTTCCTGCTGGACTCTTGACTTTGAGTTAA
TATGTTCCCATTTAACTAGCTCTTCTTTCAGACTAGGTAGGCTGCAGAGTCGGGGTGGAATGGCGGGCCTGCTTCTCAAATGAGGGAGCCAGGAGACAAGGGTGGCTTCGTGGTGGGGCATGGACTCT
CAAGGTACAACCTTGGTCCACTCTTGCCTTGGCCCACCCTTCCCTGGCTGTGTGCCTTTGGGCAAGTTACTTAGCTGCTCTGTGCCCTCCATTCCTTGAATGTAACACAAAGAAGGATTGGGTTAGAA
CTTACCTCCGGGGGTTGGGGATTTAGCTCAGTGGTAGAGCGCTTGCCTAGCAAGCGCAAGGCCCTGGGTTCGGTCCCCAGCTTCGGGGAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006252188 ⟹ XP_006252250

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	41,802,701 - 41,841,004 (-)	NCBI
mRatBN7.2	15	37,626,746 - 37,665,053 (-)	NCBI
Rnor_6.0	15	46,555,552 - 46,593,778 (-)	NCBI
Rnor_5.0	15	50,317,854 - 50,355,753 (-)	NCBI

Sequence:

show sequence

TAGCACCATTGAAAAGCAAAGCAAAAACCAACAGACTGAGAGGACCCCACCCTAGTTCCCACAGGTGGTGCGGACAGAACCCTCTGAAAAATACTTTCTGGAGATAGTTAGAGGTGTGTCGACCCCAA
CAAACCAATGGAGGGAAAACACCAGCCACGTGGTAAACCAAAACCCATGAGAAAACTCTGGGGTACCAGAGGGGCAATATGACCAGCATGGCTGAACGTCAGGTGCCCACGGAACTTCCTCAAGAGGA
TCTCTGGGGCTGAGGAGCCAGAATTCTCCAGAAGGCTTGGCTGGAGGGTGGAGCTCACGTTGAACTGCTTCTTGGGGCTTTTGATGGAAGTCTGATCACAACGGGGGCACACACACCTCTGAATGCTG
TTAGCAGGAAGCCACAAGCCACTGAAGCTGACTGAGATGAGAAGAATCCATCTGGGGATGGGATTGGTTTGTCGTAACTGGGTCCAGAGCTTCTGGTTGCTGCTAGAAGATTCTTCAACCACATGCAC
CCTGGGATCTGAACAGCTATGTTGAAAGGCTACTGAAGCCCTGCAAGAGGCTGAGAGTCGGGAGCCAGGTGATGAGCTCTTGCTGTGCTCGCTCATATAAGACCTCAAGCTGTGACCTACGACCTTTG
GCTGAAGAAGTTTCTACCCCCAAGAGACTCTGGCGCCAGCTTTCCTGGGGACGTGATTCTGCTGAGTCTGCTTCTATGCCCTGTGGGCTACTCAGGCTATTCCTGAGGATGGGGCTACTGAGCAGCAA
GAGGCAGATCAGCGAGAAGAGCAAGAGCTGGAGCCCTGTGAAGGCCCGCGCCCAGGGCAAGGTACCCCCGCCCCTGCCACCCCTGGTTGTCTTCAACCACCTCCCTCCTCCATCTCCTAACCAGCACC
CAGATGAAGAGGAGCGTTTTGTGGTGGCCCTGTTTGACTATGCCGCTGTGAATGACAGGGACCTGCAAGTGCTAAAGGGAGAGAAGCTCCAAGTCTTGAAGAGCACTGGAGACTGGTGGTTGGCCAGG
TCACTCGTCACAGGAAGAGAAGGCTATGTGCCCAGCAACTTTGTGGCCCCAGTAGAGACCCTGGAAGTAGAAAAATGGTTCTTCAGGACCATTAGCCGGAAGGATGCTGAGAGGCAGTTGCTGGCTCC
AATGAACAAAGCCGGCTCCTTTCTCATCAGAGAGAGTGAGAGCAATAAAGGTGCCTTTTCCCTATCTGTGAAAGACGTCACCAGCCAGGGGGAGATGGTCAAGCACTATAAGATCCGCTCACTGGACA
ATGGAGGCTATTACATCTCGCCCCGGATCACCTTCCCCACCCTCCAGGCCCTGGTGCAGCACTATTCTGAGAAAGGGGACGGTTTGTGTCAGAAGTTGACCCTGCCCTGTGTGAACCCAGCCCCGAAG
AATCCCTGGGCCCAAGACGAATGGGAAATCCCCAGGCAGTCCCTCAAGTTGGTCCGGAAACTTGGGTCTGGGCAGTTTGGTGAAGTCTGGATGGGTTATTACAAAAATAACATGAAGGTGGCAATCAA
GACCCTGAAGGAGGGAACCATGTCTCCGGAAGCTTTCCTGGGTGAGGCCAACGTGATGAAAACCCTGCAGCATGAGAGGCTGGTCCGTCTCTACGCCGTGGTCACCAGAGAGCCCATCTACATTGTCA
CGGAATACATGGCCAGAGGATGCTTGCTGGATTTTCTGAAGACCGATGAAGGTAGCAGATTGTCCCTTCCAAGGCTGATTGACATGTCAGCCCAGGTTGCAGAAGGGATGGCTTACATAGAGCGCATG
AATTCCATCCACCGTGACCTGCGGGCAGCCAACATCCTGGTGTCTGAGACCTTGTGCTGCAAAATCGCTGACTTCGGCTTGGCCAGGATCATCGACAGTGAATATACTGCCCAAGAGGGGGCCAAGTT
CCCCATCAAGTGGACTGCCCCAGAAGCCATCCACTTCGGGGTGTTTACCATCAAGGCTGATGTGTGGTCCTTTGGAGTCTTGCTGATGGAGATTGTCACATATGGGCGTGTTCCCTACCCAGGAATGA
GCAACCCTGAGGTCATCCGTAGCCTGGAGCATGGCTACCGAATGCCATGCCCAGAGACATGTCCGCCTGAGTTGTACCATGACGTCATCACTGAGTGCTGGCGAGGCCGACCTGAGGAGCGGCCTACC
TTTGAGTTCCTGCAGTCAGTGCTGGAGGACTTCTACACAGCCACGGAGGGCCAATATGAGCTGCAGCCTTAGCAGCAAATAGGCTCTTCAGTGTTCCCTGCCTGAGTCTCCTTCCTGCTGGACTCTTG
ACTTTGAGTTAATATGTTCCCATTTAACTAGCTCTTCTTTCAGACTAGGTAGGCTGCAGAGTCGGGGTGGAATGGCGGGCCTGCTTCTCAAATGAGGGAGCCAGGAGACAAGGGTGGCTTCGTGGTGG
GGCATGGACTCTCAAGGTACAACCTTGGTCCACTCTTGCCTTGGCCCACCCTTCCCTGGCTGTGTGCCTTTGGGCAAGTTACTTAGCTGCTCTGTGCCCTCCATTCCTTGAATGTAACACAAAGAAGG
ATTGGGTTAGAACTTACCTCCGGGGGTTGGGGATTTAGCTCAGTGGTAGAGCGCTTGCCTAGCAAGCGCAAGGCCCTGGGTTCGGTCCCCAGCTTCGGGGAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039093550 ⟹ XP_038949478

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	41,802,701 - 41,813,892 (-)	NCBI
mRatBN7.2	15	37,626,746 - 37,637,948 (-)	NCBI


Protein RefSeqs	NP_001020922	(Get FASTA)	NCBI Sequence Viewer
	XP_006252250	(Get FASTA)	NCBI Sequence Viewer
	XP_038949478	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH98683	(Get FASTA)	NCBI Sequence Viewer
	EDL85321	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000015021
	ENSRNOP00000015021.4

RefSeq Acc Id:

NP_001020922 ⟸ NM_001025751

- UniProtKB:

Q4KM97 (UniProtKB/TrEMBL), F7EWL4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGLLSSKRQISEKSKSWSPVKARAQGKVPPPLPPLVVFNHLPPPSPNQHPDEEERFVVALFDYAAVNDRDLQVLKGEKLQVLKSTGDWWLARSLVTGREGYVPSNFVAPVETLEVEKWFFRTISRKDA
ERQLLAPMNKAGSFLIRESESNKGAFSLSVKDVTSQGEMVKHYKIRSLDNGGYYISPRITFPTLQALVQHYSEKGDGLCQKLTLPCVNPAPKNPWAQDEWEIPRQSLKLVRKLGSGQFGEVWMGYYKN
NMKVAIKTLKEGTMSPEAFLGEANVMKTLQHERLVRLYAVVTREPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQVAEGMAYIERMNSIHRDLRAANILVSETLCCKIADFGLARIIDSEYT
AQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEIVTYGRVPYPGMSNPEVIRSLEHGYRMPCPETCPPELYHDVITECWRGRPEERPTFEFLQSVLEDFYTATEGQYELQP

hide sequence

RefSeq Acc Id:

XP_006252250 ⟸ XM_006252188

- Peptide Label:

isoform X1

- Sequence:

show sequence

MSSCCARSYKTSSCDLRPLAEEVSTPKRLWRQLSWGRDSAESASMPCGLLRLFLRMGLLSSKRQISEKSKSWSPVKARAQGKVPPPLPPLVVFNHLPPPSPNQHPDEEERFVVALFDYAAVNDRDLQV
LKGEKLQVLKSTGDWWLARSLVTGREGYVPSNFVAPVETLEVEKWFFRTISRKDAERQLLAPMNKAGSFLIRESESNKGAFSLSVKDVTSQGEMVKHYKIRSLDNGGYYISPRITFPTLQALVQHYSE
KGDGLCQKLTLPCVNPAPKNPWAQDEWEIPRQSLKLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKTLQHERLVRLYAVVTREPIYIVTEYMARGCLLDFLKTDEGSRLSLP
RLIDMSAQVAEGMAYIERMNSIHRDLRAANILVSETLCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEIVTYGRVPYPGMSNPEVIRSLEHGYRMPCPETCPPE
LYHDVITECWRGRPEERPTFEFLQSVLEDFYTATEGQYELQP

hide sequence

Ensembl Acc Id:

ENSRNOP00000015021 ⟸ ENSRNOT00000015021

RefSeq Acc Id:	XP_038949478 ⟸ XM_039093550
- Peptide Label:	isoform X2

Protein Domains

Protein kinase SH2 SH3

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q4KM97-F1-model_v2	AlphaFold	Q4KM97	1-499	view protein structure

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Database	Acc Id	Source(s)
BioCyc Gene	G2FUF-13429	BioCyc
Ensembl Genes	ENSRNOG00000010798	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000015021	ENTREZGENE
	ENSRNOT00000015021.7	UniProtKB/TrEMBL
Gene3D-CATH	3.30.505.10	UniProtKB/TrEMBL
	Phosphorylase Kinase, domain 1	UniProtKB/TrEMBL
	SH3 Domains	UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7385175	IMAGE-MGC_LOAD
InterPro	Kinase-like_dom	UniProtKB/TrEMBL
	Non-receptor_tyrosine_kinases	UniProtKB/TrEMBL
	Prot_kinase_cat_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
	Ser-Thr/Tyr-Pkinase	UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
	SH2_dom_sf	UniProtKB/TrEMBL
	SH3-like_dom	UniProtKB/TrEMBL
	SH3_domain	UniProtKB/TrEMBL
	Tyr_Pkinase_cat_dom	UniProtKB/TrEMBL
KEGG Report	rno:364403	UniProtKB/TrEMBL
MGC_CLONE	MGC:112647	IMAGE-MGC_LOAD
NCBI Gene	364403	ENTREZGENE
PANTHER	TYROSINE-PROTEIN KINASE	UniProtKB/TrEMBL
Pfam	Pkinase_Tyr	UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
	SH3_1	UniProtKB/TrEMBL
PharmGKB	BLK	RGD
PhenoGen	Blk	PhenoGen
PRINTS	SH2DOMAIN	UniProtKB/TrEMBL
	SH3DOMAIN	UniProtKB/TrEMBL
	TYRKINASE	UniProtKB/TrEMBL
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000010798	RatGTEx
SMART	SH2	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
	TyrKc	UniProtKB/TrEMBL
Superfamily-SCOP	Kinase_like	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
	SSF55550	UniProtKB/TrEMBL
UniProt	F7EWL4	ENTREZGENE, UniProtKB/TrEMBL
	Q4KM97	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2014-07-09	Blk	BLK proto-oncogene, Src family tyrosine kinase	Blk	B lymphoid tyrosine kinase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-25	Blk	B lymphoid tyrosine kinase	Blk	B lymphoid kinase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Blk	B lymphoid kinase	Blk_predicted	B lymphoid kinase (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Blk_predicted	B lymphoid kinase (predicted)			Symbol and Name status set to approved	70820	APPROVED