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Gene: BLK (BLK proto-oncogene, Src family tyrosine kinase) Homo sapiens
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Symbol: BLK
Name: BLK proto-oncogene, Src family tyrosine kinase
Description: Exhibits non-membrane spanning protein tyrosine kinase activity. Involved in B cell receptor signaling pathway; peptidyl-tyrosine phosphorylation; and positive regulation of insulin secretion. Predicted to localize to extrinsic component of cytoplasmic side of plasma membrane. Implicated in maturity-onset diabetes of the young type 11 and systemic lupus erythematosus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: b lymphocyte kinase; B lymphoid tyrosine kinase; BLK nonreceptor tyrosine kinase; MGC10442; MODY11; p55-Blk; tyrosine-protein kinase Blk
Orthologs:
Mus musculus (house mouse) : Blk (B lymphoid kinase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Blk (BLK proto-oncogene, Src family tyrosine kinase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Blk (BLK proto-oncogene, Src family tyrosine kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : BLK (BLK proto-oncogene, Src family tyrosine kinase)
Canis lupus familiaris (dog) : BLK (BLK proto-oncogene, Src family tyrosine kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Blk (BLK proto-oncogene, Src family tyrosine kinase)
Sus scrofa (pig) : BLK (BLK proto-oncogene, Src family tyrosine kinase)
Chlorocebus sabaeus (African green monkey) : BLK (BLK proto-oncogene, Src family tyrosine kinase)
Heterocephalus glaber (naked mole-rat) : Blk (BLK proto-oncogene, Src family tyrosine kinase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl811,486,894 - 11,564,599 (+)EnsemblGRCh38hg38GRCh38
GRCh38811,493,991 - 11,564,599 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37811,351,521 - 11,422,108 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36811,388,930 - 11,459,517 (+)NCBINCBI36hg18NCBI36
Build 34811,388,929 - 11,459,516NCBI
Celera810,480,897 - 10,551,454 (+)NCBI
Cytogenetic Map8p23.1NCBI
HuRef810,282,885 - 10,353,426 (+)NCBIHuRef
CHM1_1811,416,813 - 11,487,683 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - uncurated

Genomics

Comparative Map Data
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Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
Nomenclature History
 
More on BLK
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1318874
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-03-31
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.