CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: zearalenone
Accession: CHEBI:10106
browse the term
Definition: A macrolide comprising a fourteen-membered lactone fused to 1,3-dihydroxybenzene; a potent estrogenic metabolite produced by some Giberella species.
Synonyms: exact_synonym: (3S,11E)-14,16-dihydroxy-3-methyl-3,4,5,6,9,10-hexahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione
related_synonym: (10S)-Zearalenone; (S)-Zearalenone; (S-(E))-3,4,5,6,9,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione; 6-(10-Hydroxy-6-oxo-trans-1-undecenyl)-beta-resorcylic acid lactone; Formula=C18H22O5; InChI=1S/C18H22O5/c1-12-6-5-9-14(19)8-4-2-3-7-13-10-15(20)11-16(21)17(13)18(22)23-12/h3,7,10-12,20-21H,2,4-6,8-9H2,1H3/b7-3+/t12-/m0/s1; InChIKey=MBMQEIFVQACCCH-QBODLPLBSA-N; SMILES=C[C@H]1CCCC(=O)CCC\\C=C\\c2cc(O)cc(O)c2C(=O)O1; trans-Zearalenone
xref: AGR:IND608145868; CAS:17924-92-4; KEGG:C09981; KNApSAcK:C00003025; LIPID_MAPS_instance:LMPK04000016
xref_mesh: MESH:D015025
xref: PMID:17339071; PMID:18027362; PMID:18221829; PMID:18280460; PMID:18692541; PMID:20654554; PMID:38449531; Reaxys:4875541
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Aars1
alanyl-tRNA synthetase 1
decreases expression
EXP
Zearalenone results in decreased expression of AARS1 protein
CTD
PMID:25058043 PMID:36252740
NCBI chr 8:111,759,781...111,784,237
Ensembl chr 8:111,759,776...111,784,296
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Abcb1a
ATP-binding cassette, sub-family B member 1A
multiple interactions increases expression decreases expression affects expression
ISO
fulvestrant inhibits the reaction [Zearalenone results in increased expression of ABCB1A mRNA] Zearalenone results in increased expression of ABCB1 mRNA; Zearalenone results in increased expression of ABCB1A mRNA Zearalenone results in decreased expression of ABCB1A mRNA Zearalenone affects the expression of ABCB1A protein
CTD
PMID:20607812 PMID:22521637 PMID:23707492 PMID:29627501
NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
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Abcb1b
ATP-binding cassette, sub-family B member 1B
decreases expression increases expression
ISO
Zearalenone results in decreased expression of ABCB1B mRNA Zearalenone results in increased expression of ABCB1B mRNA; Zearalenone results in increased expression of ABCB1B protein
CTD
PMID:22521637 PMID:23707492
NCBI chr 5:8,848,147...8,916,314
Ensembl chr 5:8,848,147...8,916,315
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Abcc1
ATP-binding cassette, sub-family C member 1
increases expression increases transport multiple interactions affects expression decreases expression
ISO
Zearalenone results in increased expression of ABCC1 protein ABCC1 protein results in increased transport of Zearalenone verlukast inhibits the reaction [ABCC1 protein results in increased transport of Zearalenone]; Zearalenone inhibits the reaction [ABCC1 protein results in increased transport of calcein AM] Zearalenone affects the expression of ABCC1 mRNA; Zearalenone affects the expression of ABCC1 protein Zearalenone results in decreased expression of ABCC1 mRNA; Zearalenone results in decreased expression of ABCC1 protein
CTD
PMID:19580841 PMID:19647055 PMID:22521637 PMID:23707492
NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601
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Abcc2
ATP-binding cassette, sub-family member 2
increases expression multiple interactions increases transport
ISO
Zearalenone results in increased expression of ABCC2 mRNA verlukast inhibits the reaction [ABCC2 protein results in increased transport of Zearalenone]; Zearalenone inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]
CTD
PMID:19580841 PMID:19647055
NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179
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Abcc3
ATP-binding cassette, sub-family C member 3
decreases expression multiple interactions affects expression
ISO
Zearalenone results in decreased expression of ABCC3 mRNA Zearalenone inhibits the reaction [ABCC3 protein results in increased transport of calcein AM] Zearalenone affects the expression of ABCC3 mRNA; Zearalenone affects the expression of ABCC3 protein
CTD
PMID:19371625 PMID:19647055 PMID:22521637
NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823
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Abcc4
ATP-binding cassette, sub-family C member 4
multiple interactions decreases expression increases expression
ISO
fulvestrant inhibits the reaction [Zearalenone results in increased expression of ABCC4 mRNA] Zearalenone results in decreased expression of ABCC4 protein Zearalenone results in increased expression of ABCC4 mRNA; Zearalenone results in increased expression of ABCC4 protein
CTD
PMID:23707492
NCBI chr14:118,720,104...118,945,475
Ensembl chr14:118,720,104...118,943,631
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Abcc5
ATP-binding cassette, sub-family C member 5
multiple interactions affects expression increases expression decreases expression
ISO
fulvestrant inhibits the reaction [Zearalenone results in increased expression of ABCC5 mRNA] Zearalenone affects the expression of ABCC5 protein Zearalenone results in decreased expression of ABCC5 mRNA
CTD
PMID:23707492 PMID:29627501
NCBI chr16:20,150,053...20,245,178
Ensembl chr16:20,150,053...20,245,144
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Abcg2
ATP binding cassette subfamily G member 2 (Junior blood group)
increases expression decreases expression increases transport
ISO EXP
Zearalenone results in increased expression of ABCG2 mRNA Zearalenone results in increased expression of ABCG2 mRNA; Zearalenone results in increased expression of ABCG2 protein Zearalenone results in decreased expression of ABCG2 mRNA; Zearalenone results in decreased expression of ABCG2 protein ABCG2 protein results in increased transport of Zearalenone
CTD
PMID:19580841 PMID:22521637 PMID:23707492 PMID:30576553
NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661
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Abracl
ABRA C-terminal like
decreases expression
EXP
Zearalenone results in decreased expression of ABRACL protein
CTD
PMID:36252740
NCBI chr10:17,887,008...17,899,000
Ensembl chr10:17,887,008...17,899,036
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Acaca
acetyl-Coenzyme A carboxylase alpha
increases expression
EXP
Zearalenone results in increased expression of ACACA mRNA
CTD
PMID:38159578
NCBI chr11:84,020,461...84,292,477
Ensembl chr11:84,020,498...84,292,477
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Acat2
acetyl-Coenzyme A acetyltransferase 2
decreases expression
EXP
Zearalenone results in decreased expression of ACAT2 protein
CTD
PMID:25058043
NCBI chr17:13,161,929...13,179,612
Ensembl chr17:13,161,777...13,179,634
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Ackr2
atypical chemokine receptor 2
decreases expression
ISO
Zearalenone results in decreased expression of ACKR2 mRNA
CTD
PMID:19371625
NCBI chr 9:121,727,421...121,740,177
Ensembl chr 9:121,727,421...121,740,140
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Aco1
aconitase 1
decreases expression
EXP
Zearalenone results in decreased expression of ACO1 protein
CTD
PMID:36252740
NCBI chr 4:40,143,429...40,199,011
Ensembl chr 4:40,143,081...40,198,338
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Acsf2
acyl-CoA synthetase family member 2
increases expression
EXP
Zearalenone results in increased expression of ACSF2 protein
CTD
PMID:25058043
NCBI chr11:94,447,928...94,492,822
Ensembl chr11:94,447,928...94,492,697
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Actr3
ARP3 actin-related protein 3
multiple interactions
EXP
[Zearalenone co-treated with CGA protein] results in increased expression of ACTR3 protein
CTD
PMID:25058043
NCBI chr 1:125,320,642...125,363,464
Ensembl chr 1:125,320,642...125,363,464
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Adamts9
ADAM metallopeptidase with thrombospondin type 1 motif 9
increases expression decreases expression
ISO
Zearalenone results in increased expression of ADAMTS9 mRNA Zearalenone results in decreased expression of ADAMTS9 mRNA
CTD
PMID:17557909 PMID:19371625
NCBI chr 6:92,749,680...92,921,431
Ensembl chr 6:92,749,680...92,920,473
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Adh7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
decreases expression
EXP
Zearalenone results in decreased expression of ADH7 protein
CTD
PMID:25058043
NCBI chr 3:137,903,828...137,937,803
Ensembl chr 3:137,923,521...137,939,143
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Aff3
AF4/FMR2 family, member 3
increases expression
ISO
Zearalenone results in increased expression of AFF3 mRNA
CTD
PMID:36828454
NCBI chr 1:38,212,936...38,704,036
Ensembl chr 1:38,216,407...38,704,036
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Agfg2
ArfGAP with FG repeats 2
increases expression
EXP
Zearalenone results in increased expression of AGFG2 protein
CTD
PMID:36252740
NCBI chr 5:137,648,725...137,683,068
Ensembl chr 5:137,648,725...137,682,988
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Agt
angiotensinogen
increases expression
ISO
Zearalenone results in increased expression of AGT mRNA
CTD
PMID:36828454
NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445
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Ahr
aryl-hydrocarbon receptor
increases expression
ISO
Zearalenone results in increased expression of AHR mRNA
CTD
PMID:32119988
NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037
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Ahsa1
AHA1, activator of heat shock protein ATPase 1
multiple interactions
EXP
[Zearalenone co-treated with CGA protein] results in increased expression of AHSA1 protein
CTD
PMID:25058043
NCBI chr12:87,313,189...87,320,772
Ensembl chr12:87,313,253...87,320,772
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Aicda
activation-induced cytidine deaminase
increases expression
ISO
Zearalenone results in increased expression of AICDA mRNA
CTD
PMID:27757495
NCBI chr 6:122,530,768...122,541,139
Ensembl chr 6:122,530,760...122,541,139
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Aifm1
apoptosis-inducing factor, mitochondrion-associated 1
increases expression
EXP
Zearalenone results in increased expression of AIFM1 protein
CTD
PMID:25058043
NCBI chr X:47,563,821...47,602,440
Ensembl chr X:47,563,821...47,602,440
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Akr1b1
aldo-keto reductase family 1 member B
decreases expression
EXP
Zearalenone results in decreased expression of AKR1B1 protein
CTD
PMID:36252740
NCBI chr 6:34,280,865...34,294,424
Ensembl chr 6:34,279,369...34,294,413
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Akr1b8
aldo-keto reductase family 1, member B8
decreases expression
EXP
Zearalenone results in decreased expression of AKR1B8 protein
CTD
PMID:25058043 PMID:36252740
NCBI chr 6:34,331,081...34,345,396
Ensembl chr 6:34,331,054...34,345,398
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Akr1c14
aldo-keto reductase family 1, member C14
decreases expression
EXP
Zearalenone results in decreased expression of AKR1C14 protein
CTD
PMID:36252740
NCBI chr13:4,099,015...4,140,569
Ensembl chr13:4,099,011...4,140,688
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Akr1cl
aldo-keto reductase family 1, member C-like
decreases expression
EXP
Zearalenone results in decreased expression of AKR1CL protein
CTD
PMID:36252740
NCBI chr 1:65,052,237...65,071,918
Ensembl chr 1:65,051,848...65,071,918
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Akt1
thymoma viral proto-oncogene 1
decreases expression increases expression decreases phosphorylation multiple interactions
EXP ISO
Zearalenone results in decreased expression of AKT1 protein Zearalenone results in increased expression of AKT1 mRNA Zearalenone results in decreased phosphorylation of AKT1 protein [Zearalenone co-treated with deoxynivalenol] results in decreased phosphorylation of AKT1 protein
CTD
PMID:31419471 PMID:32119988 PMID:32858132 PMID:35090964
NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
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Akt3
thymoma viral proto-oncogene 3
decreases expression
EXP
Zearalenone results in decreased expression of AKT3 mRNA
CTD
PMID:30717214
NCBI chr 1:176,847,642...177,091,688
Ensembl chr 1:176,847,639...177,085,769
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Alad
aminolevulinate, delta-, dehydratase
multiple interactions decreases activity
EXP
lycopene inhibits the reaction [Zearalenone results in decreased activity of ALAD protein]
CTD
PMID:25682699
NCBI chr 4:62,422,762...62,438,300
Ensembl chr 4:62,427,406...62,438,155
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Alb
albumin
multiple interactions affects expression decreases expression
ISO EXP
[deoxynivalenol co-treated with Zearalenone] affects the expression of ALB mRNA; [deoxynivalenol co-treated with Zearalenone] results in decreased expression of ALB protein; [deoxynivalenol co-treated with Zearalenone] results in increased expression of ALB mRNA Zearalenone affects the expression of ALB mRNA Zearalenone results in decreased expression of ALB protein
CTD
PMID:28865950 PMID:28935499 PMID:34537261
NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461
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Aldob
aldolase B, fructose-bisphosphate
increases expression multiple interactions
ISO
Zearalenone results in increased expression of ALDOB mRNA [deoxynivalenol co-treated with Zearalenone] affects the expression of ALDOB mRNA; [deoxynivalenol co-treated with Zearalenone] results in increased expression of ALDOB mRNA
CTD
PMID:28865950 PMID:28935499
NCBI chr 4:49,535,993...49,549,546
Ensembl chr 4:49,535,995...49,549,546
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Aldoc
aldolase C, fructose-bisphosphate
decreases expression multiple interactions
EXP
Zearalenone results in decreased expression of ALDOA protein; Zearalenone results in decreased expression of ALDOC protein Nicotinamide Mononucleotide inhibits the reaction [Zearalenone results in decreased expression of ALDOA protein]
CTD
PMID:25058043 PMID:38159578
NCBI chr11:78,213,899...78,218,607
Ensembl chr11:78,213,794...78,218,607
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Alpl
alkaline phosphatase, liver/bone/kidney
multiple interactions
ISO
[Zearalenone binds to ESR1 protein] which results in increased activity of ALPL protein; fulvestrant inhibits the reaction [[Zearalenone binds to ESR1 protein] which results in increased activity of ALPL protein]
CTD
PMID:12650720
NCBI chr 4:137,469,042...137,523,695
Ensembl chr 4:137,469,044...137,523,695
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Alppl2
alkaline phosphatase, placental-like 2
increases expression
ISO
Zearalenone results in increased expression of ALPG mRNA
CTD
PMID:19371625
NCBI chr 1:87,014,412...87,023,656
Ensembl chr 1:87,014,416...87,017,650
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Anapc1
anaphase promoting complex subunit 1
increases expression
ISO
Zearalenone results in increased expression of ANAPC1 mRNA
CTD
PMID:19371625
NCBI chr 2:128,452,003...128,529,558
Ensembl chr 2:128,452,024...128,529,311
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Ano1
anoctamin 1, calcium activated chloride channel
increases expression
ISO
Zearalenone results in increased expression of ANO1 mRNA
CTD
PMID:19371625
NCBI chr 7:144,142,286...144,305,762
Ensembl chr 7:144,142,286...144,305,711
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Anp32a
acidic nuclear phosphoprotein 32 family member A
decreases expression
EXP
Zearalenone results in decreased expression of ANP32A protein
CTD
PMID:36252740
NCBI chr 9:62,248,637...62,286,084
Ensembl chr 9:62,248,575...62,286,094
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Anp32b
acidic nuclear phosphoprotein 32 family member B
decreases expression
EXP
Zearalenone results in decreased expression of ANP32B protein
CTD
PMID:36252740
NCBI chr 4:46,450,926...46,472,657
Ensembl chr 4:46,450,902...46,472,657
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Anp32e
acidic nuclear phosphoprotein 32 family member E
decreases expression
EXP
Zearalenone results in decreased expression of ANP32E protein
CTD
PMID:36252740
NCBI chr 3:95,836,557...95,854,699
Ensembl chr 3:95,836,558...95,854,702
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Anxa3
annexin A3
decreases expression
EXP
Zearalenone results in decreased expression of ANXA3 protein
CTD
PMID:25058043
NCBI chr 5:96,941,257...96,993,825
Ensembl chr 5:96,941,198...96,993,825
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Anxa5
annexin A5
affects binding
EXP
Zearalenone binds to ANXA5 protein
CTD
PMID:24412631
NCBI chr 3:36,503,072...36,530,036
Ensembl chr 3:36,503,072...36,530,043
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Anxa7
annexin A7
decreases expression
EXP
Zearalenone results in decreased expression of ANXA7 protein
CTD
PMID:25058043
NCBI chr14:20,505,344...20,530,009
Ensembl chr14:20,505,328...20,530,201
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Apaf1
apoptotic peptidase activating factor 1
increases expression
EXP
Zearalenone results in increased expression of APAF1 mRNA
CTD
PMID:34537261
NCBI chr10:90,825,173...90,918,688
Ensembl chr10:90,825,173...90,918,632
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Apln
apelin
decreases expression
ISO
Zearalenone results in decreased expression of APLN mRNA
CTD
PMID:17557909
NCBI chr X:47,114,023...47,123,730
Ensembl chr X:47,114,023...47,123,730
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Apobec1
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
increases expression
ISO
Zearalenone results in increased expression of APOBEC1 mRNA
CTD
PMID:17557909
NCBI chr 6:122,554,755...122,580,068
Ensembl chr 6:122,554,751...122,579,403
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Apoe
apolipoprotein E
decreases expression
ISO
Zearalenone results in decreased expression of APOE mRNA
CTD
PMID:19371625
NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113
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Aprt
adenine phosphoribosyl transferase
decreases expression
EXP
Zearalenone results in decreased expression of APRT protein
CTD
PMID:36252740
NCBI chr 8:123,301,376...123,303,646
Ensembl chr 8:123,301,374...123,303,648
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Aqp5
aquaporin 5
increases expression
ISO
Zearalenone results in increased expression of AQP5 mRNA
CTD
PMID:36828454
NCBI chr15:99,488,909...99,492,710
Ensembl chr15:99,488,663...99,492,710
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Ar
androgen receptor
multiple interactions decreases expression decreases activity
ISO EXP
[15-acetyldeoxynivalenol co-treated with 3-acetyldeoxynivalenol co-treated with deoxynivalenol co-treated with zearalenol co-treated with Zearalenone] results in decreased activity of AR protein; Zearalenone inhibits the reaction [Metribolone results in increased activity of AR protein]; Zearalenone inhibits the reaction [Testosterone binds to and results in increased activity of AR protein] Zearalenone results in decreased expression of AR mRNA Zearalenone metabolite results in decreased activity of AR protein; Zearalenone results in decreased activity of AR protein
CTD
PMID:18324785 PMID:21803136 PMID:24412631 PMID:25455890 PMID:27481073
NCBI chr X:97,192,363...97,366,824
Ensembl chr X:97,192,375...97,366,821
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Arhgap26
Rho GTPase activating protein 26
increases expression
ISO
Zearalenone results in increased expression of ARHGAP26 mRNA
CTD
PMID:36828454
NCBI chr18:38,734,531...39,509,338
Ensembl chr18:39,126,198...39,509,337 Ensembl chr18:39,126,198...39,509,337
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Arnt
aryl hydrocarbon receptor nuclear translocator
increases expression
ISO
Zearalenone results in increased expression of ARNT mRNA
CTD
PMID:20607812
NCBI chr 3:95,341,674...95,404,551
Ensembl chr 3:95,341,699...95,404,551
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As3mt
arsenite methyltransferase
decreases expression
EXP
Zearalenone results in decreased expression of AS3MT protein
CTD
PMID:36252740
NCBI chr19:46,695,124...46,729,538
Ensembl chr19:46,695,897...46,729,538
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Asah1
N-acylsphingosine amidohydrolase 1
decreases expression
ISO
Zearalenone results in decreased expression of ASAH1 mRNA
CTD
PMID:19371625
NCBI chr 8:41,793,683...41,850,681
Ensembl chr 8:41,793,234...41,827,810
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Asrgl1
asparaginase like 1
increases expression
ISO
Zearalenone results in increased expression of ASRGL1 mRNA
CTD
PMID:19371625
NCBI chr19:9,089,083...9,112,930
Ensembl chr19:9,087,232...9,113,000
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Atg5
autophagy related 5
increases expression
EXP
Zearalenone results in increased expression of ATG5 mRNA; Zearalenone results in increased expression of ATG5 protein
CTD
PMID:34537261
NCBI chr10:44,144,325...44,240,295
Ensembl chr10:44,144,354...44,240,287
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Atic
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
decreases expression
EXP
Zearalenone results in decreased expression of ATIC protein
CTD
PMID:36252740
NCBI chr 1:71,596,315...71,618,562
Ensembl chr 1:71,596,309...71,618,790
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Atm
ataxia telangiectasia mutated
increases expression decreases expression
EXP
Zearalenone results in increased expression of ATM mRNA Zearalenone results in decreased expression of ATM mRNA; Zearalenone results in decreased expression of ATM protein
CTD
PMID:27862621 PMID:29758222
NCBI chr 9:53,348,422...53,448,125
Ensembl chr 9:53,350,449...53,448,040
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Atp1a1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
multiple interactions
EXP
[Zearalenone co-treated with CGA protein] results in decreased expression of ATP1A1 protein
CTD
PMID:25058043
NCBI chr 3:101,483,535...101,512,023
Ensembl chr 3:101,483,535...101,512,000
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Atp5pb
ATP synthase peripheral stalk-membrane subunit b
increases expression
EXP
Zearalenone results in increased expression of ATP5PB protein
CTD
PMID:25058043
NCBI chr 3:105,850,014...105,866,579
Ensembl chr 3:105,850,014...105,867,415
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Atpaf1
ATP synthase mitochondrial F1 complex assembly factor 1
decreases expression
ISO
Zearalenone results in decreased expression of ATPAF1 mRNA
CTD
PMID:19371625
NCBI chr 4:115,642,025...115,669,120
Ensembl chr 4:115,642,009...115,679,852
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Bax
BCL2-associated X protein
affects localization increases expression multiple interactions
ISO EXP
Zearalenone affects the localization of BAX protein Zearalenone results in increased expression of BAX mRNA; Zearalenone results in increased expression of BAX protein Zearalenone results in increased expression of BAX; Zearalenone results in increased expression of BAX mRNA; Zearalenone results in increased expression of BAX protein Aflatoxin B1 inhibits the reaction [Zearalenone results in increased expression of BAX mRNA]; crocin inhibits the reaction [Zearalenone results in increased expression of BAX protein]; deoxynivalenol promotes the reaction [Zearalenone results in increased expression of BAX mRNA] [Zearalenone co-treated with deoxynivalenol] results in increased expression of BAX mRNA; [Zearalenone co-treated with deoxynivalenol] results in increased expression of BAX protein
CTD
PMID:19541794 PMID:21767629 PMID:24530352 PMID:25445755 PMID:26231423 PMID:28089945 PMID:30600648 PMID:32858132 PMID:34537261 PMID:35090964 PMID:36288102 More...
NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
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Bcl2
B cell leukemia/lymphoma 2
decreases expression increases expression multiple interactions
EXP ISO
Zearalenone results in decreased expression of BCL2 mRNA; Zearalenone results in decreased expression of BCL2 protein Zearalenone results in increased expression of BCL2 mRNA crocin inhibits the reaction [Zearalenone results in decreased expression of BCL2 protein]
CTD
PMID:21767629 PMID:24412631 PMID:26231423 PMID:28089945 PMID:28965971 PMID:30600648 PMID:32858132 PMID:36288102 More...
NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
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Bdnf
brain derived neurotrophic factor
decreases expression
ISO
Zearalenone results in decreased expression of BDNF mRNA
CTD
PMID:24412706
NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352
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Becn1
beclin 1, autophagy related
increases expression multiple interactions
ISO EXP
Zearalenone results in increased expression of BECN1; Zearalenone results in increased expression of BECN1 protein acadesine promotes the reaction [Zearalenone results in increased expression of BECN1 protein]
CTD
PMID:24530352 PMID:31982503 PMID:32858132
NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112
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Bend3
BEN domain containing 3
increases expression
ISO
Zearalenone results in increased expression of BEND3 mRNA
CTD
PMID:36828454
NCBI chr10:43,355,130...43,391,413
Ensembl chr10:43,354,827...43,391,392
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Bfar
bifunctional apoptosis regulator
increases expression
EXP
Zearalenone results in increased expression of BFAR protein
CTD
PMID:36252740
NCBI chr16:13,489,722...13,521,476
Ensembl chr16:13,489,722...13,521,476
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Bicd1
BICD cargo adaptor 1
increases expression
ISO
Zearalenone results in increased expression of BICD1 mRNA
CTD
PMID:19371625
NCBI chr 6:149,310,322...149,464,827
Ensembl chr 6:149,310,384...149,464,827
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Bid
BH3 interacting domain death agonist
multiple interactions increases activity
ISO
benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Zearalenone results in increased activity of BID protein]
CTD
PMID:30600648
NCBI chr 6:120,870,080...120,894,074
Ensembl chr 6:120,868,891...120,893,814
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Birc5
baculoviral IAP repeat-containing 5
increases expression
ISO
Zearalenone results in increased expression of BIRC5 mRNA
CTD
PMID:28965971
NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569
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Blnk
B cell linker
decreases expression
ISO
Zearalenone results in decreased expression of BLNK mRNA
CTD
PMID:36828454
NCBI chr19:40,917,371...40,982,664
Ensembl chr19:40,917,371...40,982,978
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Bmf
BCL2 modifying factor
decreases expression
ISO
Zearalenone results in decreased expression of BMF mRNA
CTD
PMID:36828454
NCBI chr 2:118,359,238...118,385,240
Ensembl chr 2:118,359,238...118,380,168
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Bmp3
bone morphogenetic protein 3
decreases expression
ISO
Zearalenone results in decreased expression of BMP3 mRNA
CTD
PMID:36828454
NCBI chr 5:99,002,274...99,031,912
Ensembl chr 5:99,002,274...99,032,255
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Bnip1
BCL2/adenovirus E1B interacting protein 1
increases expression
ISO
Zearalenone results in increased expression of BNIP1 mRNA
CTD
PMID:19371625
NCBI chr17:26,999,876...27,011,539
Ensembl chr17:27,000,040...27,011,539
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Bola2
bolA family member 2
decreases expression
EXP
Zearalenone results in decreased expression of BOLA2 protein
CTD
PMID:36252740
NCBI chr 7:126,295,172...126,295,865
Ensembl chr 7:126,294,573...126,298,970
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Braf
Braf transforming gene
increases expression
EXP
Zearalenone results in increased expression of BRAF protein
CTD
PMID:29758222
NCBI chr 6:39,580,171...39,702,592
Ensembl chr 6:39,580,171...39,702,397
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Brca1
breast cancer 1, early onset
increases expression
EXP ISO
Zearalenone results in increased expression of BRCA1 mRNA
CTD
PMID:28552778 PMID:28965971
NCBI chr11:101,379,587...101,442,808
Ensembl chr11:101,379,590...101,442,781
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Bud31
BUD31 homolog
increases expression
EXP
Zearalenone results in increased expression of BUD31 protein
CTD
PMID:36252740
NCBI chr 5:145,077,186...145,084,888
Ensembl chr 5:145,077,172...145,084,888
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C1galt1c1
C1GALT1-specific chaperone 1
increases expression
EXP
Zearalenone results in increased expression of C1GALT1C1 protein
CTD
PMID:36252740
NCBI chr X:37,719,660...37,724,020
Ensembl chr X:37,719,662...37,723,964
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C3
complement component 3
increases expression
ISO
Zearalenone results in increased expression of C3 mRNA
CTD
PMID:17557909
NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136
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Cables1
CDK5 and Abl enzyme substrate 1
increases expression
ISO
Zearalenone results in increased expression of CABLES1 mRNA
CTD
PMID:19371625 PMID:36828454
NCBI chr18:11,972,600...12,078,681
Ensembl chr18:11,972,277...12,078,687
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Cadm1
cell adhesion molecule 1
increases expression
ISO
Zearalenone results in increased expression of CADM1 mRNA
CTD
PMID:36828454
NCBI chr 9:47,441,468...47,773,578
Ensembl chr 9:47,441,471...47,769,413
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Calr
calreticulin
multiple interactions
EXP
[Zearalenone co-treated with CGA protein] results in decreased expression of CALR protein
CTD
PMID:25058043
NCBI chr 8:85,568,717...85,573,560
Ensembl chr 8:85,568,479...85,573,563
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Camkk2
calcium/calmodulin-dependent protein kinase kinase 2, beta
increases phosphorylation multiple interactions
EXP
Zearalenone results in increased phosphorylation of CAMKK2 protein 2-aminoethyl diphenylborinate inhibits the reaction [Zearalenone results in increased phosphorylation of CAMKK2 protein]; STO 609 inhibits the reaction [Zearalenone results in increased phosphorylation of CAMKK2 protein]
CTD
PMID:31982503
NCBI chr 5:122,856,064...122,918,295
Ensembl chr 5:122,869,233...122,917,472
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Capn9
calpain 9
increases expression
ISO
Zearalenone results in increased expression of CAPN9 mRNA
CTD
PMID:19371625
NCBI chr 8:125,301,361...125,345,470
Ensembl chr 8:125,302,850...125,345,470
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Car12
carbonic anhydrase 12
increases expression
ISO
Zearalenone results in increased expression of CA12 mRNA
CTD
PMID:33419253 PMID:36828454
NCBI chr 9:66,619,026...66,674,127
Ensembl chr 9:66,620,968...66,674,127
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Car2
carbonic anhydrase 2
increases expression
ISO
Zearalenone results in increased expression of CA2 mRNA
CTD
PMID:19371625
NCBI chr 3:14,951,329...14,965,830
Ensembl chr 3:14,951,333...14,965,830
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Carhsp1
calcium regulated heat stable protein 1
decreases expression
EXP
Zearalenone results in decreased expression of CARHSP1 protein
CTD
PMID:36252740
NCBI chr16:8,476,444...8,490,017
Ensembl chr16:8,476,444...8,490,019
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Cars1
cysteinyl-tRNA synthetase 1
increases expression
ISO
Zearalenone results in increased expression of CARS1 mRNA
CTD
PMID:19371625
NCBI chr 7:143,110,967...143,153,827
Ensembl chr 7:143,110,967...143,153,827
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Casp1
caspase 1
multiple interactions increases expression
EXP ISO
[Dextran Sulfate co-treated with Zearalenone] results in increased expression of CASP1 mRNA; [Dextran Sulfate co-treated with Zearalenone] results in increased expression of CASP1 protein Zearalenone results in increased expression of CASP1 mRNA; Zearalenone results in increased expression of CASP1 protein 3-methyladenine promotes the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of CASP1 protein modified form]; [Zearalenone co-treated with Lipopolysaccharides] results in increased expression of CASP1 protein; [Zearalenone co-treated with Lipopolysaccharides] results in increased expression of CASP1 protein modified form; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of CASP1 protein modified form]; NLRP3 protein promotes the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of CASP1 protein modified form]; pyrrolidine dithiocarbamic acid inhibits the reaction [Zearalenone results in increased expression of CASP1 protein modified form]; Sirolimus inhibits the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of CASP1 protein modified form]
CTD
PMID:30270565 PMID:31586597
NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290
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Casp3
caspase 3
increases activity multiple interactions increases expression increases cleavage decreases expression
ISO EXP
Zearalenone results in increased activity of CASP3 protein HERPUD1 protein promotes the reaction [Zearalenone results in increased expression of CASP3 protein modified form]; RIPK1 protein affects the reaction [Zearalenone results in increased cleavage of CASP3 protein]; scutellarin affects the reaction [RIPK1 protein affects the reaction [Zearalenone results in increased cleavage of CASP3 protein]]; scutellarin inhibits the reaction [Zearalenone results in increased cleavage of CASP3 protein]; Zearalenone promotes the reaction [deoxynivalenol results in increased expression of CASP3 mRNA] Zearalenone results in increased expression of CASP3 mRNA; Zearalenone results in increased expression of CASP3 protein modified form [Zearalenone co-treated with Aflatoxin B1] promotes the reaction [deoxynivalenol results in increased expression of CASP3 mRNA]; [Zearalenone co-treated with deoxynivalenol] results in increased expression of CASP3 protein benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Zearalenone results in increased cleavage of CASP3 protein]; Zearalenone results in decreased expression of and results in increased cleavage of CASP3 protein Zearalenone results in decreased expression of CASP3 protein
CTD
PMID:19541794 PMID:19705349 PMID:24530352 PMID:25445755 PMID:28089945 PMID:30394307 PMID:30600648 PMID:30668976 PMID:32858132 PMID:34537261 PMID:35090964 PMID:36252740 PMID:36288102 More...
NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
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Casp8
caspase 8
multiple interactions increases expression increases cleavage
ISO
[Aflatoxin B1 co-treated with deoxynivalenol] promotes the reaction [Zearalenone results in increased expression of CASP8 mRNA]; [Zearalenone co-treated with Aflatoxin B1] promotes the reaction [deoxynivalenol results in increased expression of CASP8 mRNA]; [Zearalenone co-treated with deoxynivalenol] promotes the reaction [Aflatoxin B1 results in increased expression of CASP8 mRNA]; Zearalenone promotes the reaction [[Aflatoxin B1 co-treated with deoxynivalenol] results in increased expression of CASP8 mRNA] Zearalenone results in increased cleavage of CASP8 protein
CTD
PMID:30600648 PMID:30668976
NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662
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Casp9
caspase 9
increases activity increases expression multiple interactions increases cleavage
ISO EXP
Zearalenone results in increased activity of CASP9 protein Zearalenone results in increased expression of CASP9 mRNA Zearalenone promotes the reaction [[Aflatoxin B1 co-treated with deoxynivalenol] results in increased expression of CASP9 mRNA] Zearalenone results in increased cleavage of CASP9 protein benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Zearalenone results in increased cleavage of CASP9 protein] Zearalenone results in increased expression of CASP9 protein modified form
CTD
PMID:24530352 PMID:30600648 PMID:30668976 PMID:34537261 PMID:36288102
NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
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Cat
catalase
increases expression decreases expression decreases activity multiple interactions increases activity
EXP ISO
Zearalenone results in increased expression of CAT mRNA Zearalenone results in decreased expression of CAT protein Zearalenone results in decreased expression of CAT mRNA; Zearalenone results in decreased expression of CAT protein Zearalenone results in decreased activity of CAT protein Gallic Acid inhibits the reaction [Zearalenone results in decreased activity of CAT protein] [Nicotinamide Mononucleotide co-treated with Zearalenone] results in decreased expression of CAT protein; crocin inhibits the reaction [Zearalenone results in increased activity of CAT protein]
CTD
PMID:26231423 PMID:28089945 PMID:28477956 PMID:32858132 PMID:34723416 PMID:38159578 More...
NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
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Cbfa2t3
CBFA2/RUNX1 translocation partner 3
increases expression
ISO
Zearalenone results in increased expression of CBFA2T3 mRNA
CTD
PMID:19371625
NCBI chr 8:123,351,875...123,426,069
Ensembl chr 8:123,351,880...123,425,848
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Cbln1
cerebellin 1 precursor protein
increases expression
ISO
Zearalenone results in increased expression of CBLN1 mRNA
CTD
PMID:36828454
NCBI chr 8:88,195,481...88,199,220
Ensembl chr 8:88,195,033...88,199,237
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Cbr1
carbonyl reductase 1
decreases expression
EXP
Zearalenone results in decreased expression of CBR1 protein
CTD
PMID:36252740
NCBI chr16:93,404,752...93,407,226
Ensembl chr16:93,402,741...93,407,393
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Ccl21a
C-C motif chemokine ligand 21 (serine)
increases expression
ISO
Zearalenone results in increased expression of CCL21 mRNA
CTD
PMID:27757495
NCBI chr 4:42,772,860...42,773,991
Ensembl chr 4:42,772,860...42,773,993
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Ccl22
C-C motif chemokine ligand 22
increases expression
ISO
Zearalenone results in increased expression of CCL22 mRNA
CTD
PMID:27757495
NCBI chr 8:95,472,312...95,478,016
Ensembl chr 8:95,472,218...95,478,327
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Ccn5
cellular communication network factor 5
increases expression
ISO
Zearalenone results in increased expression of CCN5 mRNA
CTD
PMID:36828454
NCBI chr 2:163,662,724...163,675,066
Ensembl chr 2:163,662,781...163,675,066
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Ccna1
cyclin A1
decreases expression
EXP
Zearalenone results in decreased expression of CCNA1 mRNA
CTD
PMID:24412631
NCBI chr 3:54,952,890...54,965,055
Ensembl chr 3:54,952,890...54,962,922
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Ccnb1
cyclin B1
decreases expression
EXP
Zearalenone results in decreased expression of CCNB1 mRNA; Zearalenone results in decreased expression of CCNB1 protein
CTD
PMID:27862621 PMID:35504548
NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078
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Ccnd1
cyclin D1
decreases expression increases expression multiple interactions
EXP ISO
Zearalenone results in decreased expression of CCND1 mRNA Zearalenone results in increased expression of CCND1 mRNA; Zearalenone results in increased expression of CCND1 protein [Tamoxifen co-treated with Zearalenone] results in increased expression of CCND1 protein Zearalenone results in decreased expression of CCND1 protein
CTD
PMID:24412631 PMID:27473017 PMID:30138655 PMID:36288102
NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
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Ccnd2
cyclin D2
decreases expression
ISO
Zearalenone results in decreased expression of CCND2 mRNA
CTD
PMID:17557909 PMID:28965971
NCBI chr 6:127,102,125...127,131,913
Ensembl chr 6:127,102,125...127,129,156
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Ccne1
cyclin E1
multiple interactions
ISO
[Zearalenone co-treated with Aflatoxin B1] results in increased expression of CCNE1 mRNA
CTD
PMID:28965971
NCBI chr 7:37,797,409...37,806,915
Ensembl chr 7:37,797,409...37,806,959
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Ccr1
C-C motif chemokine receptor 1
increases expression
ISO
Zearalenone results in increased expression of CCR1 mRNA
CTD
PMID:27757495
NCBI chr 9:123,762,163...123,768,729
Ensembl chr 9:123,762,161...123,768,729
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Ccr4
C-C motif chemokine receptor 4
increases expression
ISO
Zearalenone results in increased expression of CCR4 mRNA
CTD
PMID:27757495
NCBI chr 9:114,319,384...114,334,544
Ensembl chr 9:114,319,384...114,333,984
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Cct2
chaperonin containing TCP1 subunit 2
decreases expression
EXP
Zearalenone results in decreased expression of CCT2 protein
CTD
PMID:36252740
NCBI chr10:116,886,902...116,899,757
Ensembl chr10:116,886,906...116,899,719
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Cct5
chaperonin containing TCP1 subunit 5
increases expression decreases expression
EXP
Zearalenone results in increased expression of CCT5 protein Zearalenone results in decreased expression of CCT5 protein
CTD
PMID:25058043 PMID:36252740
NCBI chr15:31,590,946...31,601,992
Ensembl chr15:31,590,946...31,601,950
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Cd274
CD274 antigen
increases expression
ISO
Zearalenone results in increased expression of CD274 mRNA
CTD
PMID:27757495
NCBI chr19:29,339,428...29,365,495
Ensembl chr19:29,344,855...29,365,495
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Cd36
CD36 molecule
multiple interactions decreases expression increases expression
EXP ISO
[Zearalenone co-treated with CGA protein] results in decreased expression of CD36 protein; Nicotinamide Mononucleotide inhibits the reaction [Zearalenone results in increased expression of CD36 mRNA] Zearalenone results in decreased expression of CD36 mRNA; Zearalenone results in decreased expression of CD36 protein
CTD
PMID:25058043 PMID:32858132 PMID:38159578
NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799
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Cd38
CD38 antigen
multiple interactions increases expression
EXP
Nicotinamide Mononucleotide inhibits the reaction [Zearalenone results in increased expression of CD38 mRNA]
CTD
PMID:38159578
NCBI chr 5:44,026,153...44,069,714
Ensembl chr 5:44,025,895...44,069,717
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Cd86
CD86 antigen
multiple interactions
ISO
[Lipopolysaccharides co-treated with Zearalenone] results in increased expression of CD86 protein
CTD
PMID:32328699
NCBI chr16:36,389,318...36,486,439
Ensembl chr16:36,424,231...36,486,443
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Cdc25c
cell division cycle 25C
decreases expression
EXP
Zearalenone results in decreased expression of CDC25C protein
CTD
PMID:35504548
NCBI chr18:34,866,046...34,884,644
Ensembl chr18:34,866,046...34,884,586
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Cdc6
cell division cycle 6
decreases expression
EXP
Zearalenone results in decreased expression of CDC6 mRNA
CTD
PMID:27862621
NCBI chr11:98,798,627...98,814,768
Ensembl chr11:98,798,627...98,814,766
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Cdca7
cell division cycle associated 7
increases expression
ISO
Zearalenone results in increased expression of CDCA7 mRNA
CTD
PMID:36828454
NCBI chr 2:72,306,540...72,317,237
Ensembl chr 2:72,306,503...72,317,237
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Cdh1
cadherin 1
decreases expression
ISO
Zearalenone results in decreased expression of CDH1 mRNA
CTD
PMID:33419253
NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878
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Cdk1
cyclin dependent kinase 1
decreases expression
EXP
Zearalenone results in decreased expression of CDK1 protein
CTD
PMID:34716709 PMID:35504548
NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768
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Cdk4
cyclin dependent kinase 4
increases expression
EXP
Zearalenone results in increased expression of CDK4 protein
CTD
PMID:27473017
NCBI chr10:126,899,404...126,903,157
Ensembl chr10:126,899,403...126,903,789
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Cdkn1a
cyclin dependent kinase inhibitor 1A
decreases expression
EXP
Zearalenone results in decreased expression of CDKN1A mRNA
CTD
PMID:24412631
NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
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Cdkn1c
cyclin dependent kinase inhibitor 1C
decreases expression
ISO
Zearalenone results in decreased expression of CDKN1C mRNA
CTD
PMID:28965971
NCBI chr 7:143,012,076...143,014,735
Ensembl chr 7:143,012,076...143,014,787
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Cdkn2a
cyclin dependent kinase inhibitor 2A
decreases expression
ISO
Zearalenone results in decreased expression of CDKN2A mRNA
CTD
PMID:28965971
NCBI chr 4:89,192,710...89,212,856
Ensembl chr 4:89,192,708...89,212,890
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Cebpa
CCAAT/enhancer binding protein alpha
affects expression multiple interactions
ISO
Zearalenone affects the expression of CEBPA mRNA [deoxynivalenol co-treated with Zearalenone] results in decreased expression of CEBPA mRNA
CTD
PMID:28865950
NCBI chr 7:34,818,718...34,821,353
Ensembl chr 7:34,818,718...34,821,353
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Cebpb
CCAAT/enhancer binding protein beta
increases expression
ISO
Zearalenone results in increased expression of CEBPB mRNA
CTD
PMID:25424538
NCBI chr 2:167,530,835...167,532,352
Ensembl chr 2:167,530,835...167,532,338
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Cebpd
CCAAT/enhancer binding protein delta
increases expression
ISO
Zearalenone results in increased expression of CEBPD mRNA
CTD
PMID:19371625
NCBI chr16:15,705,150...15,707,409
Ensembl chr16:15,705,150...15,708,895
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Cfap99
cilia and flagella associated protein 99
decreases expression
EXP
Zearalenone results in decreased expression of CFAP99 protein
CTD
PMID:36252740
NCBI chr 5:34,441,107...34,486,205
Ensembl chr 5:34,445,944...34,484,671
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Cfi
complement component factor i
increases expression
ISO
Zearalenone results in increased expression of CFI mRNA
CTD
PMID:17557909
NCBI chr 3:129,630,432...129,668,978
Ensembl chr 3:129,629,533...129,668,981
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Cga
glycoprotein hormones, alpha subunit
multiple interactions increases expression
ISO EXP
fulvestrant inhibits the reaction [Zearalenone results in increased expression of CGA protein] [Zearalenone co-treated with CGA protein] results in decreased expression of ATP1A1 protein; [Zearalenone co-treated with CGA protein] results in decreased expression of CALR protein; [Zearalenone co-treated with CGA protein] results in decreased expression of CD36 protein; [Zearalenone co-treated with CGA protein] results in decreased expression of HSD17B11 protein; [Zearalenone co-treated with CGA protein] results in decreased expression of MGLL protein; [Zearalenone co-treated with CGA protein] results in decreased expression of P4HB protein; [Zearalenone co-treated with CGA protein] results in decreased expression of SMPDL3B protein; [Zearalenone co-treated with CGA protein] results in decreased expression of SYAP1 protein; [Zearalenone co-treated with CGA protein] results in increased expression of ACTR3 protein; [Zearalenone co-treated with CGA protein] results in increased expression of AHSA1 protein; [Zearalenone co-treated with CGA protein] results in increased expression of DNM1L protein; [Zearalenone co-treated with CGA protein] results in increased expression of PDCD6IP protein; [Zearalenone co-treated with CGA protein] results in increased expression of PHGDH protein; [Zearalenone co-treated with CGA protein] results in increased expression of TLN1 protein; [Zearalenone co-treated with CGA protein] results in increased expression of YKT6 protein
CTD
PMID:19580841 PMID:25058043
NCBI chr 4:34,893,779...34,907,374
Ensembl chr 4:34,893,779...34,907,370
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Chac1
ChaC, cation transport regulator 1
increases expression
ISO
Zearalenone results in increased expression of CHAC1 mRNA
CTD
PMID:25424538
NCBI chr 2:119,181,723...119,184,807
Ensembl chr 2:119,181,710...119,184,862
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Chac2
ChaC, cation transport regulator 2
increases expression
ISO
Zearalenone results in increased expression of CHAC2 mRNA
CTD
PMID:19371625
NCBI chr11:30,926,707...30,936,365
Ensembl chr11:30,926,707...30,936,350
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Chchd3
coiled-coil-helix-coiled-coil-helix domain containing 3
increases expression
EXP
Zearalenone results in increased expression of CHCHD3 protein
CTD
PMID:25058043
NCBI chr 6:32,769,142...33,037,206
Ensembl chr 6:32,767,911...33,037,195
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Chek1
checkpoint kinase 1
increases expression decreases phosphorylation
EXP
Zearalenone results in increased expression of CHEK1 protein Zearalenone results in decreased phosphorylation of CHK1 protein
CTD
PMID:34716709 PMID:35504548
NCBI chr 9:36,619,935...36,637,897
Ensembl chr 9:36,619,778...36,638,361
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Chek2
checkpoint kinase 2
decreases expression
EXP
Zearalenone results in decreased expression of CHEK2 protein
CTD
PMID:35504548
NCBI chr 5:110,987,668...111,022,006
Ensembl chr 5:110,987,845...111,022,011
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Chordc1
cysteine and histidine rich domain containing 1
decreases expression
EXP
Zearalenone results in decreased expression of CHORDC1 protein
CTD
PMID:36252740
NCBI chr 9:18,203,563...18,225,296
Ensembl chr 9:18,203,421...18,228,738
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Cish
cytokine inducible SH2-containing protein
increases expression
ISO
Zearalenone results in increased expression of CISH mRNA
CTD
PMID:36828454
NCBI chr 9:107,173,858...107,179,983
Ensembl chr 9:107,173,225...107,179,983
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Ckb
creatine kinase, brain
decreases expression
EXP
Zearalenone results in decreased expression of CKB protein
CTD
PMID:36252740
NCBI chr12:111,635,789...111,638,772
Ensembl chr12:111,635,795...111,638,772
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Cldn1
claudin 1
multiple interactions decreases expression
ISO
[deoxynivalenol co-treated with Zearalenone] results in decreased expression of CLDN1 mRNA; [deoxynivalenol co-treated with Zearalenone] results in decreased expression of CLDN1 protein Zearalenone results in decreased expression of CLDN1 protein
CTD
PMID:28865950 PMID:28935499
NCBI chr16:26,175,395...26,190,589
Ensembl chr16:26,175,392...26,190,591
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Cldn8
claudin 8
decreases expression
ISO
Zearalenone results in decreased expression of CLDN8 mRNA
CTD
PMID:36828454
NCBI chr16:88,357,714...88,360,071
Ensembl chr16:88,357,716...88,360,071
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Cnfn
cornifelin
decreases expression
ISO
Zearalenone results in decreased expression of CNFN mRNA
CTD
PMID:19371625
NCBI chr 7:25,067,041...25,069,149
Ensembl chr 7:25,067,045...25,069,149
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Cnn3
calponin 3, acidic
decreases expression
EXP
Zearalenone results in decreased expression of CNN3 protein
CTD
PMID:36252740
NCBI chr 3:121,220,190...121,251,854
Ensembl chr 3:121,220,146...121,251,856
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Coa5
cytochrome C oxidase assembly factor 5
increases expression
EXP
Zearalenone results in increased expression of COA5 protein
CTD
PMID:36252740
NCBI chr 1:37,456,166...37,469,184
Ensembl chr 1:37,456,165...37,469,184
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Cops8
COP9 signalosome subunit 8
decreases expression
EXP
Zearalenone results in decreased expression of COPS8 protein
CTD
PMID:36252740
NCBI chr 1:90,531,147...90,541,063
Ensembl chr 1:90,530,703...90,541,063
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Coro1c
coronin, actin binding protein 1C
increases expression
ISO
Zearalenone results in increased expression of CORO1C mRNA
CTD
PMID:19371625
NCBI chr 5:113,980,500...114,046,767
Ensembl chr 5:113,980,497...114,046,819
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Cpt1a
carnitine palmitoyltransferase 1a, liver
multiple interactions increases expression
EXP
Nicotinamide Mononucleotide inhibits the reaction [Zearalenone results in increased expression of CPT1A mRNA]
CTD
PMID:38159578
NCBI chr19:3,372,328...3,435,735
Ensembl chr19:3,372,334...3,435,733
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Cpt2
carnitine palmitoyltransferase 2
increases expression
EXP
Zearalenone results in increased expression of CPT2 protein
CTD
PMID:25058043 PMID:36252740
NCBI chr 4:107,761,179...107,780,786
Ensembl chr 4:107,761,178...107,780,807
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Crabp2
cellular retinoic acid binding protein II
decreases expression
EXP
Zearalenone results in decreased expression of CRABP2 protein
CTD
PMID:36252740
NCBI chr 3:87,856,000...87,860,679
Ensembl chr 3:87,855,973...87,860,683
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Crybg2
crystallin beta-gamma domain containing 2
decreases expression
ISO
Zearalenone results in decreased expression of CRYBG2 mRNA
CTD
PMID:36828454
NCBI chr 4:133,788,042...133,819,815
Ensembl chr 4:133,788,126...133,819,815
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Cse1l
chromosome segregation 1 like
decreases expression
EXP
Zearalenone results in decreased expression of CSE1L protein
CTD
PMID:36252740
NCBI chr 2:166,747,961...166,788,309
Ensembl chr 2:166,747,960...166,788,309
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Csf2
colony stimulating factor 2 (granulocyte-macrophage)
increases expression
ISO
Zearalenone results in increased expression of CSF2 mRNA
CTD
PMID:27757495
NCBI chr11:54,138,096...54,140,725
Ensembl chr11:54,138,097...54,140,493
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Cst6
cystatin E/M
decreases expression
ISO
Zearalenone results in decreased expression of CST6 mRNA
CTD
PMID:28965971
NCBI chr19:5,394,733...5,399,602
Ensembl chr19:5,394,733...5,399,602
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Ctla4
cytotoxic T-lymphocyte-associated protein 4
increases expression
ISO
Zearalenone results in increased expression of CTLA4 mRNA
CTD
PMID:27757495
NCBI chr 1:60,948,184...60,954,991
Ensembl chr 1:60,926,159...60,954,991
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Ctnnb1
catenin beta 1
decreases expression
ISO EXP
Zearalenone results in decreased expression of CTNNB1 protein
CTD
PMID:36288102
NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573
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Ctsd
cathepsin D
increases expression
ISO
Zearalenone results in increased expression of CTSD mRNA
CTD
PMID:28965971
NCBI chr 7:141,929,647...141,941,564
Ensembl chr 7:141,929,648...141,941,775
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Cuta
cutA divalent cation tolerance homolog
decreases expression
ISO
Zearalenone results in decreased expression of CUTA mRNA
CTD
PMID:19371625
NCBI chr17:27,156,946...27,158,847
Ensembl chr17:27,152,793...27,158,543
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Cux1
cut-like homeobox 1
decreases expression
ISO
Zearalenone results in decreased expression of CUX1 mRNA
CTD
PMID:19371625
NCBI chr 5:136,276,989...136,596,429
Ensembl chr 5:136,276,989...136,596,344
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Cuzd1
CUB and zona pellucida-like domains 1
increases expression
ISO
Zearalenone results in increased expression of CUZD1 mRNA
CTD
PMID:17557909
NCBI chr 7:130,910,283...130,924,021
Ensembl chr 7:130,910,283...130,924,021
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Cxcl12
C-X-C motif chemokine ligand 12
increases expression
ISO
Zearalenone results in increased expression of CXCL12 mRNA
CTD
PMID:27757495 PMID:28396216
NCBI chr 6:117,145,496...117,158,329
Ensembl chr 6:117,145,496...117,158,328
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Cxcl15
C-X-C motif chemokine ligand 15
increases expression
ISO
Zearalenone results in increased expression of CXCL8 mRNA
CTD
PMID:27757495
NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
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Cxcl9
C-X-C motif chemokine ligand 9
increases expression
ISO
Zearalenone results in increased expression of CXCL9 mRNA
CTD
PMID:27757495
NCBI chr 5:92,469,190...92,475,938
Ensembl chr 5:92,469,206...92,475,938
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Cxcr5
C-X-C motif chemokine receptor 5
increases expression
ISO
Zearalenone results in increased expression of CXCR5 mRNA
CTD
PMID:27757495
NCBI chr 9:44,423,084...44,437,741
Ensembl chr 9:44,423,084...44,473,174
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Cycs
cytochrome c, somatic
affects localization increases expression
ISO EXP
Zearalenone affects the localization of CYCS protein Zearalenone results in increased expression of CYCS protein
CTD
PMID:19541794 PMID:25058043
NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518
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Cyp11a1
cytochrome P450, family 11, subfamily a, polypeptide 1
decreases expression multiple interactions decreases activity
EXP ISO
Zearalenone results in decreased expression of CYP11A1 mRNA; Zearalenone results in decreased expression of CYP11A1 protein [Colforsin co-treated with Zearalenone] results in increased expression of CYP11A1 mRNA Zearalenone results in decreased activity of CYP11A1 protein
CTD
PMID:24512812 PMID:26783879 PMID:29669061 PMID:31419471
NCBI chr 9:57,905,307...57,934,314
Ensembl chr 9:57,913,694...57,934,306
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Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
decreases expression
EXP ISO
Zearalenone results in decreased expression of CYP17A1 mRNA
CTD
PMID:24512812 PMID:32858132
NCBI chr19:46,655,604...46,661,439
Ensembl chr19:46,655,604...46,661,611
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Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
decreases activity decreases expression
ISO EXP
Zearalenone results in decreased activity of CYP19A1 protein Zearalenone results in decreased expression of CYP19A1 mRNA; Zearalenone results in decreased expression of CYP19A1 protein
CTD
PMID:16023337 PMID:29758222 PMID:36374910
NCBI chr 9:54,073,221...54,175,448
Ensembl chr 9:54,073,221...54,175,394
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions decreases activity decreases expression
ISO
Tamoxifen inhibits the reaction [Zearalenone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]]; Tamoxifen inhibits the reaction [Zearalenone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]]; Zearalenone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Zearalenone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] Zearalenone results in decreased activity of CYP1A1 protein Zearalenone results in decreased expression of CYP1A1 mRNA
CTD
PMID:15157572 PMID:34181028
NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
increases hydroxylation multiple interactions decreases abundance decreases activity
ISO
CYP1A2 protein results in increased hydroxylation of Zearalenone [CYP1A2 protein results in increased hydroxylation of Zearalenone] which results in increased chemical synthesis of Catechols CYP1A2 protein results in decreased abundance of Zearalenone Zearalenone results in decreased activity of CYP1A2 protein
CTD
PMID:19931366 PMID:38341109
NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
increases activity multiple interactions
ISO
Zearalenone results in increased activity of CYP1B1 protein Zearalenone promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1B1 protein]
CTD
PMID:15157572
NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490
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Cyp2c65
cytochrome P450, family 2, subfamily c, polypeptide 65
decreases activity
ISO
Zearalenone results in decreased activity of CYP2C9 protein
CTD
PMID:38341109
NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
increases expression
ISO
Zearalenone results in increased expression of CYP2E1 mRNA
CTD
PMID:20607812
NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900
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Cyp4f18
cytochrome P450, family 4, subfamily f, polypeptide 18
decreases expression multiple interactions
ISO
Zearalenone results in decreased expression of CYP4F3 mRNA [deoxynivalenol co-treated with Zearalenone] results in decreased expression of CYP4F3 mRNA; [deoxynivalenol co-treated with Zearalenone] results in increased expression of CYP4F3 mRNA
CTD
PMID:28865950 PMID:28935499
NCBI chr 8:72,742,326...72,763,512
Ensembl chr 8:72,742,326...72,763,470
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Cyp51
cytochrome P450, family 51
increases expression
EXP
Zearalenone results in increased expression of CYP51 protein
CTD
PMID:25058043
NCBI chr 5:4,130,674...4,154,697
Ensembl chr 5:4,131,145...4,154,746
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Cysrt1
cysteine rich tail 1
decreases expression
ISO
Zearalenone results in decreased expression of CYSRT1 mRNA
CTD
PMID:36828454
NCBI chr 2:25,128,831...25,129,876
Ensembl chr 2:25,128,830...25,132,464
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Dars1
aspartyl-tRNA synthetase 1
decreases expression
EXP
Zearalenone results in decreased expression of DARS1 protein
CTD
PMID:25058043
NCBI chr 1:128,291,444...128,345,153
Ensembl chr 1:128,291,444...128,345,105
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Dazl
deleted in azoospermia-like
decreases expression
EXP
Zearalenone results in decreased expression of DAZL mRNA; Zearalenone results in decreased expression of DAZL protein
CTD
PMID:28552778 PMID:31419471
NCBI chr17:50,586,422...50,600,627
Ensembl chr17:50,586,423...50,600,664
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Ddc
dopa decarboxylase
decreases expression
ISO
Zearalenone results in decreased expression of DDC mRNA
CTD
PMID:24412706
NCBI chr11:11,764,101...11,848,144
Ensembl chr11:11,764,101...11,848,144
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Ddit3
DNA-damage inducible transcript 3
multiple interactions increases expression
EXP
2-aminoethyl diphenylborinate inhibits the reaction [Zearalenone results in increased expression of DDIT3 protein]; 4-phenylbutylamine promotes the reaction [Zearalenone results in increased expression of DDIT3 protein]
CTD
PMID:30394307 PMID:31982503
NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157 Ensembl chr10:127,126,643...127,132,157
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Ddit4l
DNA-damage-inducible transcript 4-like
decreases expression
ISO
Zearalenone results in decreased expression of DDIT4L mRNA
CTD
PMID:36828454
NCBI chr 3:137,329,433...137,334,093
Ensembl chr 3:137,327,373...137,334,094
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Ddx25
DEAD box helicase 25
decreases expression
EXP
Zearalenone results in decreased expression of DDX25 mRNA
CTD
PMID:24412631
NCBI chr 9:35,453,144...35,469,766
Ensembl chr 9:35,447,943...35,469,824
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Ddx4
DEAD box helicase 4
decreases expression
EXP
Zearalenone results in decreased expression of DDX4 protein; Zearalenone results in decreased expression of VASA protein
CTD
PMID:28089945 PMID:31419471
NCBI chr13:112,734,867...112,790,342
Ensembl chr13:112,734,867...112,789,009
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Deptor
DEP domain containing MTOR-interacting protein
increases expression
ISO
Zearalenone results in increased expression of DEPTOR mRNA
CTD
PMID:33419253 PMID:36828454
NCBI chr15:54,975,824...55,122,667
Ensembl chr15:54,975,713...55,122,667
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Dgat1
diacylglycerol O-acyltransferase 1
increases expression multiple interactions
EXP
Zearalenone results in increased expression of DGAT1 mRNA Nicotinamide Mononucleotide inhibits the reaction [Zearalenone results in increased expression of DGAT1 mRNA]
CTD
PMID:38159578
NCBI chr15:76,386,215...76,396,167
Ensembl chr15:76,386,215...76,396,153
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Dgat2
diacylglycerol O-acyltransferase 2
multiple interactions increases expression
EXP
Nicotinamide Mononucleotide inhibits the reaction [Zearalenone results in increased expression of DGAT2 mRNA]
CTD
PMID:38159578
NCBI chr 7:98,802,870...98,831,920
Ensembl chr 7:98,802,865...98,831,926
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Dhrs2
dehydrogenase/reductase member 2
increases expression
ISO
Zearalenone results in increased expression of DHRS2 mRNA
CTD
PMID:36828454
NCBI chr14:55,459,464...55,478,897
Ensembl chr14:55,459,464...55,478,892
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Dhrs3
dehydrogenase/reductase 3
increases expression
ISO
Zearalenone results in increased expression of DHRS3 mRNA
CTD
PMID:19371625
NCBI chr 4:144,618,712...144,654,214
Ensembl chr 4:144,619,397...144,654,779
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Dio3os
deiodinase, iodothyronine type III, opposite strand
decreases expression
EXP
Zearalenone results in decreased expression of DIO3OS mRNA
CTD
PMID:30790392
NCBI chr12:110,241,818...110,244,502
Ensembl chr12:110,241,813...110,244,609
G
Dkk2
dickkopf WNT signaling pathway inhibitor 2
decreases expression
EXP
Zearalenone results in decreased expression of DKK2 mRNA
CTD
PMID:27862621
NCBI chr 3:131,791,027...131,886,065
Ensembl chr 3:131,791,053...131,886,065
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Dld
dihydrolipoamide dehydrogenase
increases expression
EXP
Zearalenone results in increased expression of DLD protein
CTD
PMID:25058043
NCBI chr12:31,381,561...31,401,470
Ensembl chr12:31,381,276...31,401,452
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Dmbt1
deleted in malignant brain tumors 1
increases expression
ISO
Zearalenone results in increased expression of DMBT1 mRNA
CTD
PMID:17557909
NCBI chr 7:130,633,787...130,723,357
Ensembl chr 7:130,633,776...130,723,357
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Dnm1l
dynamin 1-like
multiple interactions
EXP
[Zearalenone co-treated with CGA protein] results in increased expression of DNM1L protein
CTD
PMID:25058043
NCBI chr16:16,130,092...16,176,863
Ensembl chr16:16,130,094...16,176,823
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Dnmt1
DNA methyltransferase 1
increases expression
ISO
Zearalenone results in increased expression of DNMT1 mRNA
CTD
PMID:32119988
NCBI chr 9:20,818,501...20,871,084
Ensembl chr 9:20,818,505...20,871,184
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Dohh
deoxyhypusine hydroxylase/monooxygenase
decreases expression
EXP
Zearalenone results in decreased expression of DOHH protein
CTD
PMID:36252740
NCBI chr10:81,220,268...81,224,186
Ensembl chr10:81,220,262...81,224,186
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Dok4
docking protein 4
increases expression
ISO
Zearalenone results in increased expression of DOK4 mRNA
CTD
PMID:19371625
NCBI chr 8:95,590,456...95,602,940
Ensembl chr 8:95,590,456...95,602,958
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Dpysl2
dihydropyrimidinase-like 2
decreases expression
EXP
Zearalenone results in decreased expression of DPYSL2 protein
CTD
PMID:25058043
NCBI chr14:67,040,313...67,148,490
Ensembl chr14:67,040,313...67,148,410
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Dstn
destrin
decreases expression
EXP
Zearalenone results in decreased expression of DSTN protein
CTD
PMID:36252740
NCBI chr 2:143,757,251...143,785,244
Ensembl chr 2:143,757,240...143,785,244
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Dusp2
dual specificity phosphatase 2
increases expression
ISO
Zearalenone results in increased expression of DUSP2 mRNA
CTD
PMID:36828454
NCBI chr 2:127,178,079...127,180,297
Ensembl chr 2:127,178,079...127,180,296
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Dvl1
dishevelled segment polarity protein 1
increases expression
ISO
Zearalenone results in increased expression of DVL1 mRNA
CTD
PMID:32858132
NCBI chr 4:155,931,829...155,943,760
Ensembl chr 4:155,931,859...155,943,760
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Dync1li2
dynein, cytoplasmic 1 light intermediate chain 2
decreases expression
EXP
Zearalenone results in decreased expression of DYNC1LI2 protein
CTD
PMID:36252740
NCBI chr 8:105,144,306...105,170,415
Ensembl chr 8:105,144,312...105,169,679
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Ech1
enoyl coenzyme A hydratase 1, peroxisomal
decreases expression
ISO
Zearalenone results in decreased expression of ECH1 mRNA
CTD
PMID:19371625
NCBI chr 7:28,524,763...28,531,664
Ensembl chr 7:28,524,642...28,531,672
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Echs1
enoyl Coenzyme A hydratase, short chain, 1, mitochondrial
decreases expression
ISO
Zearalenone results in decreased expression of ECHS1 mRNA; Zearalenone results in decreased expression of ECHS1 protein
CTD
PMID:32858132
NCBI chr 7:139,685,623...139,696,334
Ensembl chr 7:139,685,623...139,696,389
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Eef1b2
eukaryotic translation elongation factor 1 beta 2
decreases expression
EXP
Zearalenone results in decreased expression of EEF1B2 protein
CTD
PMID:36252740
NCBI chr 1:63,215,990...63,219,645
Ensembl chr 1:63,215,984...63,219,645
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Eef1ece2
Eef1akmt4-endothelin converting enzyme 2 readthrough
decreases expression
EXP
Zearalenone results in decreased expression of ECE2 protein
CTD
PMID:36252740
NCBI chr16:20,430,351...20,464,665
Ensembl chr16:20,430,360...20,464,670
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Efl1
elongation factor like GTPase 1
decreases expression
EXP
Zearalenone results in decreased expression of EFL1 protein
CTD
PMID:36252740
NCBI chr 7:82,297,811...82,427,060
Ensembl chr 7:82,297,822...82,427,060
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Egr1
early growth response 1
increases expression
ISO
Zearalenone results in increased expression of EGR1 mRNA
CTD
PMID:36828454
NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037
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Ehmt2
euchromatic histone lysine N-methyltransferase 2
increases expression
ISO
Zearalenone results in increased expression of EHMT2 mRNA
CTD
PMID:32119988
NCBI chr17:35,117,427...35,133,049
Ensembl chr17:35,117,445...35,133,028
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Eif1ax
eukaryotic translation initiation factor 1A, X-linked
decreases expression
EXP
Zearalenone results in decreased expression of EIF1AX protein
CTD
PMID:36252740
NCBI chr X:158,155,174...158,172,617
Ensembl chr X:158,155,174...158,172,924
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Eif4ebp1
eukaryotic translation initiation factor 4E binding protein 1
decreases phosphorylation
ISO
Zearalenone results in decreased phosphorylation of EIF4EBP1 protein
CTD
PMID:32858132
NCBI chr 8:27,750,355...27,765,684
Ensembl chr 8:27,750,357...27,766,702
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Elovl3
ELOVL fatty acid elongase 3
multiple interactions increases expression
EXP
Nicotinamide Mononucleotide inhibits the reaction [Zearalenone results in increased expression of ELOVL3 mRNA]
CTD
PMID:38159578
NCBI chr19:46,120,336...46,124,133
Ensembl chr19:46,120,336...46,124,133
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Ep300
E1A binding protein p300
decreases expression
ISO
Zearalenone results in decreased expression of EP300 protein
CTD
PMID:36288102
NCBI chr15:81,470,329...81,536,273
Ensembl chr15:81,469,552...81,536,278
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Epas1
endothelial PAS domain protein 1
increases expression
EXP
Zearalenone results in increased expression of EPAS1 mRNA
CTD
PMID:30138655
NCBI chr17:87,061,292...87,140,838
Ensembl chr17:87,061,128...87,140,838
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Epb41l2
erythrocyte membrane protein band 4.1 like 2
increases expression
ISO
Zearalenone results in increased expression of EPB41L2 mRNA
CTD
PMID:19371625
NCBI chr10:25,235,680...25,399,413
Ensembl chr10:25,235,696...25,399,417
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Ephb3
Eph receptor B3
decreases expression
ISO
Zearalenone results in decreased expression of EPHB3 mRNA
CTD
PMID:36828454
NCBI chr16:21,023,530...21,042,054
Ensembl chr16:21,023,505...21,042,055
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Ephb4
Eph receptor B4
increases expression
EXP
Zearalenone results in increased expression of EPHB4 protein
CTD
PMID:36252740
NCBI chr 5:137,348,371...137,372,784
Ensembl chr 5:137,348,371...137,376,931
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Epn3
epsin 3
decreases expression
ISO
Zearalenone results in decreased expression of EPN3 mRNA
CTD
PMID:19371625
NCBI chr11:94,380,425...94,390,800
Ensembl chr11:94,380,425...94,390,800
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Erbb3
erb-b2 receptor tyrosine kinase 3
decreases expression
ISO
Zearalenone results in decreased expression of ERBB3 mRNA
CTD
PMID:19371625
NCBI chr10:128,403,392...128,425,504
Ensembl chr10:128,403,392...128,425,521
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Ercc3
excision repair cross-complementing rodent repair deficiency, complementation group 3
increases expression
ISO
Zearalenone results in increased expression of ERCC3 mRNA
CTD
PMID:19371625
NCBI chr18:32,373,357...32,403,206
Ensembl chr18:32,373,353...32,403,204
G
Erg
ETS transcription factor
increases expression
ISO
Zearalenone results in increased expression of ERG mRNA
CTD
PMID:36828454
NCBI chr16:95,160,028...95,387,452
Ensembl chr16:95,160,028...95,387,452
G
Erich3
glutamate rich 3
increases expression
ISO
Zearalenone results in increased expression of ERICH3 mRNA
CTD
PMID:36828454
NCBI chr 3:154,416,770...154,454,649
Ensembl chr 3:154,369,496...154,473,427
G
Erp27
endoplasmic reticulum protein 27
decreases expression
ISO
Zearalenone results in decreased expression of ERP27 mRNA
CTD
PMID:19371625
NCBI chr 6:136,884,312...136,899,465
Ensembl chr 6:136,884,309...136,899,178
G
Esco1
establishment of sister chromatid cohesion N-acetyltransferase 1
increases expression
ISO
Zearalenone results in increased expression of ESCO1 mRNA
CTD
PMID:32119988
NCBI chr18:10,566,507...10,610,863
Ensembl chr18:10,566,507...10,610,352
G
Espn
espin
increases expression
ISO
Zearalenone results in increased expression of ESPN mRNA
CTD
PMID:19371625
NCBI chr 4:152,204,788...152,236,871
Ensembl chr 4:152,204,788...152,236,828
G
Esr1
estrogen receptor 1 (alpha)
multiple interactions increases activity affects binding affects expression decreases expression affects response to substance
ISO EXP
[Zearalenone binds to ESR1 protein] which results in increased activity of ALPL protein; Fulvestrant inhibits the reaction [[Zearalenone binds to ESR1 protein] which results in increased activity of ALPL protein]; Zearalenone analog promotes the reaction [ESR1 protein binds to and results in increased activity of NCOA2 protein]; Zearalenone binds to and results in decreased activity of ESR1 protein; Zearalenone binds to and results in increased activity of ESR1 protein; Zearalenone promotes the reaction [ESR1 protein alternative form binds to ESR1 protein alternative form]; Zearalenone promotes the reaction [ESR1 protein binds to and results in increased activity of NCOA2 protein]; Zearalenone promotes the reaction [NCOA2 protein binds to ESR1 protein] Zearalenone results in increased activity of ESR1 protein Zearalenone affects the expression of ESR1 mRNA; Zearalenone affects the expression of ESR1 protein Zearalenone analog binds to ESR1 protein; Zearalenone binds to ESR1 protein Zearalenone metabolite results in increased activity of ESR1 protein; Zearalenone results in increased activity of ESR1 protein Zearalenone results in decreased expression of ESR1 mRNA; Zearalenone results in decreased expression of ESR1 protein ESR1 protein affects the susceptibility to Zearalenone
CTD
PMID:9751507 PMID:11162928 PMID:11331656 PMID:11750080 PMID:12598185 PMID:12650720 PMID:15084758 PMID:15169976 PMID:19233257 PMID:19913605 PMID:20209442 PMID:22494775 PMID:22521637 PMID:25455890 PMID:27862621 PMID:28396216 PMID:28807876 PMID:28965971 PMID:29627501 PMID:30270565 PMID:31419471 PMID:33049310 PMID:33419253 More...
NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614
G
Esr2
estrogen receptor 2 (beta)
multiple interactions affects binding decreases expression increases expression
ISO EXP
Zearalenone analog promotes the reaction [ESR2 protein binds to and results in increased activity of NCOA2 protein]; Zearalenone binds to and results in decreased activity of ESR2 protein; Zearalenone binds to and results in increased activity of ESR2 protein; Zearalenone promotes the reaction [ESR2 protein binds to and results in increased activity of NCOA2 protein] Zearalenone binds to ESR2 protein Zearalenone analog binds to ESR2 protein; Zearalenone binds to ESR2 protein [bisphenol A co-treated with Zearalenone co-treated with Arsenic co-treated with enzacamene co-treated with Estradiol co-treated with Triiodothyronine] results in decreased expression of ESR2 mRNA; [bisphenol A co-treated with Zearalenone co-treated with Arsenic co-treated with enzacamene] results in increased expression of ESR2 mRNA; [Estradiol co-treated with Triiodothyronine] promotes the reaction [Zearalenone results in decreased expression of ESR2 mRNA]; [Zearalenone co-treated with Estradiol co-treated with Triiodothyronine] results in decreased expression of ESR2 mRNA; [Zearalenone results in increased susceptibility to [Estradiol co-treated with Triiodothyronine]] which results in decreased expression of ESR2 mRNA Zearalenone results in increased expression of ESR2 mRNA Dextran Sulfate promotes the reaction [Zearalenone results in increased expression of ESR2 mRNA]
CTD
PMID:9751507 PMID:15084758 PMID:15169976 PMID:19913605 PMID:27338438 PMID:28807876 PMID:30270565 PMID:33049310 More...
NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033
G
Etfb
electron transferring flavoprotein, beta polypeptide
increases expression
EXP
Zearalenone results in increased expression of ETFB protein
CTD
PMID:25058043
NCBI chr 7:43,093,496...43,107,224
Ensembl chr 7:43,093,507...43,107,224
G
Etfdh
electron transferring flavoprotein, dehydrogenase
increases expression
EXP
Zearalenone results in increased expression of ETFDH protein
CTD
PMID:25058043
NCBI chr 3:79,511,095...79,536,074
Ensembl chr 3:79,511,095...79,536,807
G
Etnk2
ethanolamine kinase 2
increases expression
ISO
Zearalenone results in increased expression of ETNK2 mRNA
CTD
PMID:19371625
NCBI chr 1:133,291,308...133,308,056
Ensembl chr 1:133,291,310...133,308,074
G
Fabp1
fatty acid binding protein 1, liver
increases expression
ISO
Zearalenone results in increased expression of FABP1 mRNA
CTD
PMID:32119988
NCBI chr 6:71,176,863...71,182,018
Ensembl chr 6:71,176,811...71,182,007
G
Fam107a
family with sequence similarity 107, member A
decreases expression
ISO
Zearalenone results in decreased expression of FAM107A mRNA
CTD
PMID:19371625
NCBI chr14:14,152,166...14,173,503
Ensembl chr14:14,151,750...14,173,499
G
Fas
Fas cell surface death receptor
increases expression
ISO
Zearalenone results in increased expression of FAS mRNA; Zearalenone results in increased expression of FAS protein
CTD
PMID:30600648
NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172
G
Fasl
Fas ligand
increases expression
ISO
Zearalenone results in increased expression of FASLG mRNA; Zearalenone results in increased expression of FASLG protein
CTD
PMID:30600648
NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064
G
Fasn
fatty acid synthase
increases expression multiple interactions
EXP
Zearalenone results in increased expression of FASN mRNA Nicotinamide Mononucleotide inhibits the reaction [Zearalenone results in increased expression of FASN mRNA]
CTD
PMID:38159578
NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373
G
Fdx1
ferredoxin 1
decreases expression
EXP
Zearalenone results in decreased expression of FDX1 mRNA; Zearalenone results in decreased expression of FDX1 protein
CTD
PMID:29758222
NCBI chr 9:51,854,323...51,874,902
Ensembl chr 9:51,854,606...51,874,856
G
Figla
folliculogenesis specific basic helix-loop-helix
decreases expression
EXP
Zearalenone results in decreased expression of FIGLA mRNA
CTD
PMID:28089945
NCBI chr 6:85,993,476...85,997,978
Ensembl chr 6:85,993,153...85,997,978
G
Filip1l
filamin A interacting protein 1-like
decreases expression
ISO
Zearalenone results in decreased expression of FILIP1L mRNA
CTD
PMID:36828454
NCBI chr16:57,173,376...57,393,167
Ensembl chr16:57,173,456...57,393,489
G
Fkbp4
FK506 binding protein 4
decreases expression
EXP
Zearalenone results in decreased expression of FKBP4 protein
CTD
PMID:25058043
NCBI chr 6:128,407,066...128,415,619
Ensembl chr 6:128,406,698...128,415,640
G
Fkbp5
FK506 binding protein 5
decreases expression
EXP
Zearalenone results in decreased expression of FKBP5 mRNA
CTD
PMID:24412631
NCBI chr17:28,617,727...28,705,123
Ensembl chr17:28,618,068...28,736,501
G
Fn3krp
fructosamine 3 kinase related protein
decreases expression
EXP
Zearalenone results in decreased expression of FN3KRP protein
CTD
PMID:36252740
NCBI chr11:121,312,199...121,322,114
Ensembl chr11:121,312,227...121,322,114
G
Fndc5
fibronectin type III domain containing 5
decreases expression
ISO
Zearalenone results in decreased expression of FNDC5 mRNA
CTD
PMID:19371625
NCBI chr 4:129,030,672...129,038,386
Ensembl chr 4:129,030,477...129,038,386
G
Folr1
folate receptor alpha
decreases expression
ISO
Zearalenone results in decreased expression of FOLR1 mRNA
CTD
PMID:19371625
NCBI chr 7:101,507,551...101,519,974
Ensembl chr 7:101,507,538...101,519,995
G
Fos
FBJ osteosarcoma oncogene
increases expression
EXP
Zearalenone results in increased expression of FOS protein
CTD
PMID:27473017
NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
G
Foxd1
forkhead box D1
increases expression
ISO
Zearalenone results in increased expression of FOXD1 mRNA
CTD
PMID:19371625
NCBI chr13:98,490,753...98,493,213
Ensembl chr13:98,490,750...98,495,813
G
Foxj1
forkhead box J1
decreases expression
ISO
Zearalenone results in decreased expression of FOXJ1 mRNA
CTD
PMID:19371625
NCBI chr11:116,221,530...116,226,331
Ensembl chr11:116,221,530...116,226,225
G
Foxo1
forkhead box O1
decreases expression
EXP
Zearalenone results in decreased expression of FOXO1 mRNA
CTD
PMID:30717214
NCBI chr 3:52,175,758...52,257,530
Ensembl chr 3:52,175,757...52,260,642
G
Foxo3
forkhead box O3
decreases expression
EXP
Zearalenone results in decreased expression of FOXO3 mRNA
CTD
PMID:30717214
NCBI chr10:42,057,841...42,152,691
Ensembl chr10:42,057,837...42,152,751
G
Fshb
follicle stimulating hormone beta
decreases expression multiple interactions
ISO
Zearalenone results in decreased expression of FSHB protein Gallic Acid inhibits the reaction [Zearalenone results in decreased expression of FSHB protein]
CTD
PMID:32858132 PMID:34723416
NCBI chr 2:106,886,331...106,889,996
Ensembl chr 2:106,886,485...106,890,001
G
Fshr
follicle stimulating hormone receptor
decreases expression
ISO
Zearalenone results in decreased expression of FSHR mRNA; Zearalenone results in decreased expression of FSHR protein
CTD
PMID:29669061
NCBI chr17:89,292,380...89,508,103
Ensembl chr17:89,292,380...89,508,103
G
G0s2
G0/G1 switch gene 2
increases expression
ISO
Zearalenone results in increased expression of G0S2 mRNA
CTD
PMID:19371625
NCBI chr 1:192,954,468...192,955,496
Ensembl chr 1:192,954,469...192,955,525
G
G6pdx
glucose-6-phosphate dehydrogenase X-linked
decreases activity multiple interactions
ISO
Zearalenone results in decreased activity of G6PD protein Gallic Acid inhibits the reaction [Zearalenone results in decreased activity of G6PD protein]
CTD
PMID:34723416
NCBI chr X:73,453,089...73,472,486
Ensembl chr X:73,453,089...73,472,800
G
Gadd45a
growth arrest and DNA-damage-inducible 45 alpha
increases expression
EXP
Zearalenone results in increased expression of GADD45A mRNA
CTD
PMID:27862621
NCBI chr 6:67,012,080...67,014,391
Ensembl chr 6:67,012,080...67,014,441
G
Galnt4
polypeptide N-acetylgalactosaminyltransferase 4
increases expression
ISO
Zearalenone results in increased expression of GALNT4 mRNA
CTD
PMID:19371625
NCBI chr10:98,943,997...98,949,109
Ensembl chr10:98,944,021...98,949,109
G
Galr2
galanin receptor 2
decreases expression
ISO
Zearalenone results in decreased expression of GALR2 mRNA
CTD
PMID:19371625
NCBI chr11:116,170,520...116,174,776
Ensembl chr11:116,171,765...116,174,764
G
Gap43
growth associated protein 43
decreases expression
ISO
Zearalenone results in decreased expression of GAP43 mRNA
CTD
PMID:17557909
NCBI chr16:42,068,915...42,161,014
Ensembl chr16:42,068,805...42,161,014
G
Gapdh
glyceraldehyde-3-phosphate dehydrogenase
decreases expression
EXP
Zearalenone results in decreased expression of GAPDH protein
CTD
PMID:36252740
NCBI chr 6:125,138,812...125,143,450
Ensembl chr 6:125,138,678...125,143,430
G
Gars1
glycyl-tRNA synthetase 1
decreases expression
EXP
Zearalenone results in decreased expression of GARS1 protein
CTD
PMID:36252740
NCBI chr 6:55,014,986...55,056,489
Ensembl chr 6:55,014,992...55,056,485
G
Gdf10
growth differentiation factor 10
decreases expression
ISO
Zearalenone results in decreased expression of GDF10 mRNA
CTD
PMID:17557909
NCBI chr14:33,645,544...33,658,471
Ensembl chr14:33,645,544...33,659,940
G
Gdnf
glial cell line derived neurotrophic factor
decreases expression
EXP
Zearalenone results in decreased expression of GDNF protein
CTD
PMID:31419471
NCBI chr15:7,839,529...7,867,061
Ensembl chr15:7,840,327...7,867,056
G
Gdpd5
glycerophosphodiester phosphodiesterase domain containing 5
increases expression
ISO
Zearalenone results in increased expression of GDPD5 mRNA
CTD
PMID:19371625
NCBI chr 7:99,027,976...99,111,082
Ensembl chr 7:99,030,621...99,111,084
G
Gfra2
glial cell line derived neurotrophic factor family receptor alpha 2
decreases expression
ISO
Zearalenone results in decreased expression of GFRA2 mRNA
CTD
PMID:17557909
NCBI chr14:71,127,547...71,217,280
Ensembl chr14:71,127,560...71,217,278
G
Gins3
GINS complex subunit 3
decreases expression
ISO
Zearalenone results in decreased expression of GINS3 mRNA
CTD
PMID:19371625
NCBI chr 8:96,360,187...96,371,687
Ensembl chr 8:96,360,081...96,371,688
G
Gja1
gap junction protein, alpha 1
decreases expression
EXP
Zearalenone results in decreased expression of GJA1 protein
CTD
PMID:27473017
NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609
G
Gjb1
gap junction protein, beta 1
decreases expression
EXP
Zearalenone results in decreased expression of GJB1 protein
CTD
PMID:27473017
NCBI chr X:100,419,982...100,429,235
Ensembl chr X:100,419,984...100,429,235
G
Gjb2
gap junction protein, beta 2
increases expression
ISO
Zearalenone results in increased expression of GJB2 mRNA
CTD
PMID:17557909
NCBI chr14:57,336,059...57,342,159
Ensembl chr14:57,336,057...57,342,159
G
Glg1
golgi apparatus protein 1
increases expression
EXP
Zearalenone results in increased expression of GLG1 protein
CTD
PMID:36252740
NCBI chr 8:111,879,916...111,985,842
Ensembl chr 8:111,881,053...111,985,848
G
Glrx2
glutaredoxin 2
increases expression
ISO
Zearalenone results in increased expression of GLRX2 mRNA
CTD
PMID:19371625
NCBI chr 1:143,614,787...143,625,416
Ensembl chr 1:143,592,076...143,625,414
G
Gm266
predicted gene 266
increases expression
ISO
Zearalenone results in increased expression of DIRAS3 mRNA
CTD
PMID:36828454
NCBI chr12:111,451,043...111,452,257
Ensembl chr12:111,451,043...111,452,257
G
Gnrh1
gonadotropin releasing hormone 1
decreases expression
ISO
Zearalenone results in decreased expression of GNRH1 mRNA
CTD
PMID:29627501
NCBI chr14:67,982,717...67,986,889
Ensembl chr14:67,982,630...67,986,888
G
Gnrhr
gonadotropin releasing hormone receptor
decreases expression
ISO
Zearalenone results in decreased expression of GNRHR protein
CTD
PMID:29627501
NCBI chr 5:86,328,613...86,345,760
Ensembl chr 5:86,328,613...86,345,760
G
Got2
glutamatic-oxaloacetic transaminase 2, mitochondrial
increases expression
EXP
Zearalenone results in increased expression of GOT2 protein
CTD
PMID:25058043
NCBI chr 8:96,590,761...96,615,029
Ensembl chr 8:96,590,762...96,615,175
G
Gper1
G protein-coupled estrogen receptor 1
affects binding decreases expression
ISO
Zearalenone binds to GPER1 protein Zearalenone results in decreased expression of GPER1 mRNA
CTD
PMID:17088055 PMID:28965971
NCBI chr 5:139,408,905...139,413,555
Ensembl chr 5:139,408,906...139,413,555
G
Gpr142
G protein-coupled receptor 142
increases expression
ISO
Zearalenone results in increased expression of GPR142 mRNA
CTD
PMID:19371625
NCBI chr11:114,689,750...114,697,571
Ensembl chr11:114,689,750...114,697,571
G
Gpt
glutamic pyruvic transaminase, soluble
decreases expression multiple interactions increases activity increases expression
EXP
Zearalenone results in decreased expression of GPT protein 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [corynoline inhibits the reaction [Zearalenone results in increased activity of GPT protein]]; corynoline inhibits the reaction [Zearalenone results in increased activity of GPT protein]; crocin inhibits the reaction [Zearalenone results in increased expression of GPT protein]; Plant Extracts inhibits the reaction [Zearalenone results in increased expression of GPT protein]; Zearalenone inhibits the reaction [Aflatoxin B1 results in increased activity of GPT protein]
CTD
PMID:17385802 PMID:25058043 PMID:25445755 PMID:26231423 PMID:36161741
NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886
G
Gpx1
glutathione peroxidase 1
decreases expression
ISO
Zearalenone results in decreased expression of GPX1 mRNA; Zearalenone results in decreased expression of GPX1 protein
CTD
PMID:32858132
NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542
G
Grb7
growth factor receptor bound protein 7
decreases expression
ISO
Zearalenone results in decreased expression of GRB7 mRNA
CTD
PMID:28965971
NCBI chr11:98,337,660...98,346,199
Ensembl chr11:98,337,220...98,346,199
G
Greb1
gene regulated by estrogen in breast cancer protein
increases expression
ISO
Zearalenone results in increased expression of GREB1 mRNA
CTD
PMID:19371625 PMID:22494775 PMID:28807876 PMID:33419253 PMID:36828454
NCBI chr12:16,720,616...16,851,395
Ensembl chr12:16,720,616...16,850,887
G
Gsdmd
gasdermin D
decreases expression
ISO
Zearalenone results in decreased expression of GSDMD mRNA
CTD
PMID:19371625
NCBI chr15:75,733,990...75,739,257
Ensembl chr15:75,734,176...75,739,257
G
Gspt1
G1 to S phase transition 1
decreases expression
EXP
Zearalenone results in decreased expression of GSPT1 protein
CTD
PMID:36252740
NCBI chr16:11,034,104...11,072,189
Ensembl chr16:11,037,156...11,072,189
G
Gsr
glutathione reductase
multiple interactions decreases activity
EXP
lycopene inhibits the reaction [Zearalenone results in decreased activity of GSR protein]
CTD
PMID:25682699
NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191
G
Gstm2
glutathione S-transferase, mu 2
decreases expression
EXP
Zearalenone results in decreased expression of GSTM2 protein
CTD
PMID:36252740
NCBI chr 3:107,889,018...107,893,736
Ensembl chr 3:107,889,018...107,893,769
G
Gstp1
glutathione S-transferase, pi 1
decreases expression
EXP
Zearalenone results in decreased expression of GSTP1 protein
CTD
PMID:36252740
NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985
G
H19
H19, imprinted maternally expressed transcript
decreases expression
ISO
Zearalenone results in decreased expression of H19 mRNA
CTD
PMID:17557909
NCBI chr 7:142,129,267...142,131,883
Ensembl chr 7:142,129,262...142,133,957
G
H2ax
H2A.X variant histone
increases expression decreases expression
EXP
Zearalenone results in increased expression of H2AX protein modified form Zearalenone results in decreased expression of H2AX protein
CTD
PMID:28089945 PMID:28552778 PMID:35504548 PMID:35650142
NCBI chr 9:44,246,012...44,247,374
Ensembl chr 9:44,245,991...44,247,374
G
H2bc14
H2B clustered histone 14
decreases expression
ISO
Zearalenone results in decreased expression of H2BC5 mRNA
CTD
PMID:19371625
NCBI chr13:21,906,214...21,906,696
Ensembl chr13:21,906,214...21,906,737
G
Hadhb
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
decreases expression
ISO
Zearalenone results in decreased expression of HADHB mRNA; Zearalenone results in decreased expression of HADHB protein
CTD
PMID:32858132
NCBI chr 5:30,360,251...30,389,591
Ensembl chr 5:30,360,246...30,389,591
G
Hapln3
hyaluronan and proteoglycan link protein 3
decreases expression
ISO
Zearalenone results in decreased expression of HAPLN3 mRNA
CTD
PMID:19371625
NCBI chr 7:78,766,775...78,783,100
Ensembl chr 7:78,764,850...78,780,766
G
Hat1
histone aminotransferase 1
increases expression
ISO
Zearalenone results in increased expression of HAT1 mRNA
CTD
PMID:32119988
NCBI chr 2:71,219,604...71,271,966
Ensembl chr 2:71,219,302...71,271,966
G
Hba-a1
hemoglobin alpha, adult chain 1
decreases expression
ISO
Zearalenone results in decreased expression of HBA-A1 mRNA
CTD
PMID:17557909
NCBI chr11:32,233,672...32,234,486
Ensembl chr11:32,233,511...32,234,465
G
Hbb-b1
hemoglobin, beta adult major chain
decreases expression
ISO
Zearalenone results in decreased expression of HBB mRNA
CTD
PMID:17557909
G
Herpud1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
multiple interactions increases expression
EXP
4-phenylbutylamine promotes the reaction [Zearalenone results in increased expression of HERPUD1 protein]; HERPUD1 protein inhibits the reaction [Zearalenone results in decreased phosphorylation of RPS6KB1 protein]; HERPUD1 protein promotes the reaction [Zearalenone results in decreased phosphorylation of MAPK1 protein]; HERPUD1 protein promotes the reaction [Zearalenone results in decreased phosphorylation of MAPK3 protein]; HERPUD1 protein promotes the reaction [Zearalenone results in increased expression of CASP3 protein modified form]
CTD
PMID:30394307
NCBI chr 8:95,113,057...95,121,999
Ensembl chr 8:95,113,066...95,122,005
G
Hes2
hes family bHLH transcription factor 2
increases expression
ISO
Zearalenone results in increased expression of HES2 mRNA
CTD
PMID:19371625
NCBI chr 4:152,243,324...152,246,926
Ensembl chr 4:152,243,324...152,246,926
G
Hivep1
human immunodeficiency virus type I enhancer binding protein 1
increases expression
ISO
Zearalenone results in increased expression of HIVEP1 mRNA
CTD
PMID:19371625
NCBI chr13:42,205,304...42,338,504
Ensembl chr13:42,205,497...42,346,013
G
Hk2
hexokinase 2
increases expression
ISO
Zearalenone results in increased expression of HK2 mRNA
CTD
PMID:32119988
NCBI chr 6:82,702,004...82,751,437
Ensembl chr 6:82,702,006...82,751,435
G
Hmgcs1
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1
decreases expression
ISO
Zearalenone results in decreased expression of HMGCS1 mRNA
CTD
PMID:25424538
NCBI chr13:120,151,887...120,169,796
Ensembl chr13:120,151,915...120,169,796
G
Hmgn2
high mobility group nucleosomal binding domain 2
decreases expression
ISO
Zearalenone results in decreased expression of HMGN2 mRNA
CTD
PMID:19371625
NCBI chr 4:133,692,050...133,695,302
Ensembl chr 4:133,692,049...133,695,961
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Hmox1
heme oxygenase 1
increases expression multiple interactions
EXP
Zearalenone results in increased expression of HMOX1 protein 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [corynoline promotes the reaction [Zearalenone results in increased expression of HMOX1 protein]]; corynoline promotes the reaction [Zearalenone results in increased expression of HMOX1 protein]
CTD
PMID:36161741
NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
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Hnf4a
hepatic nuclear factor 4, alpha
multiple interactions
ISO
[deoxynivalenol co-treated with Zearalenone] affects the expression of HNF4A mRNA
CTD
PMID:28865950
NCBI chr 2:163,348,731...163,414,827
Ensembl chr 2:163,348,728...163,414,830
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Hoxa10
homeobox A10
decreases expression
EXP
Zearalenone results in decreased expression of HOXA10 mRNA
CTD
PMID:27862621
NCBI chr 6:52,208,177...52,217,658
Ensembl chr 6:52,208,177...52,217,834
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Hpdl
4-hydroxyphenylpyruvate dioxygenase-like
increases expression
ISO
Zearalenone results in increased expression of HPDL mRNA
CTD
PMID:36828454
NCBI chr 4:116,677,104...116,678,705
Ensembl chr 4:116,677,101...116,678,904
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Hras
Harvey rat sarcoma virus oncogene
decreases expression
EXP
Zearalenone results in decreased expression of HRAS mRNA
CTD
PMID:30717214
NCBI chr 7:140,770,839...140,773,938
Ensembl chr 7:140,769,018...140,773,918
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Hsd11b1
hydroxysteroid 11-beta dehydrogenase 1
decreases expression
ISO
Zearalenone results in decreased expression of HSD11B1 mRNA; Zearalenone results in decreased expression of HSD11B1 protein
CTD
PMID:29669061
NCBI chr 1:192,903,917...192,946,345
Ensembl chr 1:192,903,942...192,946,383
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Hsd17b1
hydroxysteroid (17-beta) dehydrogenase 1
decreases expression
EXP
Zearalenone results in decreased expression of HSD17B1 protein
CTD
PMID:31419471
NCBI chr11:100,968,792...100,972,014
Ensembl chr11:100,969,237...100,971,353
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Hsd17b11
hydroxysteroid (17-beta) dehydrogenase 11
multiple interactions
EXP
[Zearalenone co-treated with CGA protein] results in decreased expression of HSD17B11 protein
CTD
PMID:25058043
NCBI chr 5:104,137,631...104,169,662
Ensembl chr 5:104,137,628...104,169,785
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Hsd17b14
hydroxysteroid (17-beta) dehydrogenase 14
decreases expression
ISO
Zearalenone results in decreased expression of HSD17B14 mRNA
CTD
PMID:19371625
NCBI chr 7:45,204,345...45,216,745
Ensembl chr 7:45,204,317...45,217,176
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Hsd17b2
hydroxysteroid (17-beta) dehydrogenase 2
increases expression
ISO
Zearalenone results in increased expression of HSD17B2 mRNA
CTD
PMID:20607812
NCBI chr 8:118,427,752...118,485,767
Ensembl chr 8:118,428,643...118,485,766
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Hsd17b3
hydroxysteroid (17-beta) dehydrogenase 3
decreases expression decreases activity
EXP ISO
Zearalenone results in decreased expression of HSD17B3 mRNA Zearalenone results in decreased expression of HSD17B3 mRNA; Zearalenone results in decreased expression of HSD17B3 protein Zearalenone results in decreased activity of HSD17B3 protein
CTD
PMID:24512812 PMID:29669061
NCBI chr13:64,206,088...64,237,076
Ensembl chr13:64,206,080...64,237,044
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Hsd17b4
hydroxysteroid (17-beta) dehydrogenase 4
decreases expression
EXP
Zearalenone results in decreased expression of HSD17B4 protein
CTD
PMID:31419471
NCBI chr18:50,261,268...50,329,337
Ensembl chr18:50,261,268...50,329,336
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Hsd3b1
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
decreases expression decreases activity
EXP ISO
Zearalenone results in decreased expression of HSD3B1 mRNA Zearalenone results in decreased activity of HSD3B1 protein
CTD
PMID:24512812 PMID:29669061
NCBI chr 3:98,749,672...98,767,110
Ensembl chr 3:98,759,510...98,767,110
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Hsp90ab1
heat shock protein 90 alpha (cytosolic), class B member 1
decreases expression
EXP
Zearalenone results in decreased expression of HSP90AB1 protein
CTD
PMID:36252740
NCBI chr17:45,878,704...45,884,187
Ensembl chr17:45,878,701...45,884,197
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Hspa1a
heat shock protein 1A
increases expression decreases expression
ISO EXP
Zearalenone results in increased expression of HSPA1A mRNA; Zearalenone results in increased expression of HSPA1A protein Zearalenone results in decreased expression of HSPA1A protein
CTD
PMID:19051279 PMID:36252740
NCBI chr17:35,188,335...35,191,132
Ensembl chr17:35,188,166...35,191,132
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Hspa1b
heat shock protein 1B
increases expression
ISO EXP
Zearalenone results in increased expression of HSPA1B mRNA
CTD
PMID:25424538 PMID:27862621
NCBI chr17:35,175,405...35,178,214
Ensembl chr17:35,175,412...35,178,214
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Hspa4
heat shock protein 4
decreases expression
EXP
Zearalenone results in decreased expression of HSPA4 protein
CTD
PMID:25058043
NCBI chr11:53,150,641...53,191,306
Ensembl chr11:53,150,641...53,191,284
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Hspa5
heat shock protein 5
multiple interactions increases expression
EXP
2-aminoethyl diphenylborinate inhibits the reaction [Zearalenone results in increased expression of HSPA5 protein]; 4-phenylbutylamine promotes the reaction [Zearalenone results in increased expression of HSPA5 protein]
CTD
PMID:30394307 PMID:31982503
NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559
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Hspb1
heat shock protein 1
increases expression
ISO
Zearalenone results in increased expression of HSPB1 protein
CTD
PMID:19051279
NCBI chr 5:135,916,773...135,918,417
Ensembl chr 5:135,916,773...135,918,417
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Hspb8
heat shock protein 8
decreases expression
EXP
Zearalenone results in decreased expression of HSPB8 protein
CTD
PMID:36252740
NCBI chr 5:116,546,550...116,560,923
Ensembl chr 5:116,546,550...116,560,923
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Hsph1
heat shock 105kDa/110kDa protein 1
decreases expression
EXP
Zearalenone results in decreased expression of HSPH1 protein
CTD
PMID:36252740
NCBI chr 5:149,540,308...149,562,594
Ensembl chr 5:149,537,752...149,559,841
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Id1
inhibitor of DNA binding 1, HLH protein
decreases expression
ISO
Zearalenone results in decreased expression of ID1 mRNA
CTD
PMID:25424538
NCBI chr 2:152,578,171...152,579,330
Ensembl chr 2:152,578,171...152,579,330
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Id2
inhibitor of DNA binding 2
increases expression multiple interactions
EXP
Zearalenone results in increased expression of ID2 mRNA [Tamoxifen co-treated with Zearalenone] results in increased expression of ID2 mRNA
CTD
PMID:30138655
NCBI chr12:25,143,798...25,146,091
Ensembl chr12:25,143,798...25,147,139
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Idh3a
isocitrate dehydrogenase 3 (NAD+) alpha
increases expression
EXP
Zearalenone results in increased expression of IDH3A protein
CTD
PMID:25058043
NCBI chr 9:54,493,795...54,511,946
Ensembl chr 9:54,493,618...54,511,945
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Ido1
indoleamine 2,3-dioxygenase 1
decreases expression
ISO
Zearalenone results in decreased expression of IDO1 mRNA
CTD
PMID:36828454
NCBI chr 8:25,074,148...25,086,987
Ensembl chr 8:25,074,152...25,087,025
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Ifitm3
interferon induced transmembrane protein 3
decreases expression
ISO
Zearalenone results in decreased expression of IFITM3 mRNA
CTD
PMID:19371625
NCBI chr 7:140,589,503...140,590,657
Ensembl chr 7:140,589,499...140,590,683
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Igf1
insulin-like growth factor 1
increases expression decreases expression
ISO
Zearalenone results in increased expression of IGF1 mRNA Zearalenone results in decreased expression of IGF1 mRNA
CTD
PMID:27757495 PMID:28965971
NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904
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Igfbp3
insulin-like growth factor binding protein 3
decreases expression
ISO
Zearalenone results in decreased expression of IGFBP3 mRNA
CTD
PMID:28965971 PMID:36828454
NCBI chr11:7,156,086...7,165,498
Ensembl chr11:7,156,086...7,163,923
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Igfbp6
insulin-like growth factor binding protein 6
decreases expression
ISO
Zearalenone results in decreased expression of IGFBP6 mRNA
CTD
PMID:19371625
NCBI chr15:102,052,621...102,057,947
Ensembl chr15:102,052,797...102,057,946
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Igsf9
immunoglobulin superfamily, member 9
decreases expression
ISO
Zearalenone results in decreased expression of IGSF9 mRNA
CTD
PMID:36828454
NCBI chr 1:172,307,616...172,326,444
Ensembl chr 1:172,309,355...172,326,445
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Ikzf2
IKAROS family zinc finger 2
decreases expression
ISO
Zearalenone results in decreased expression of IKZF2 mRNA
CTD
PMID:36828454
NCBI chr 1:69,570,382...69,726,510
Ensembl chr 1:69,570,373...69,726,404
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Il10
interleukin 10
multiple interactions increases expression
EXP
lycopene inhibits the reaction [Zearalenone results in increased expression of IL10]
CTD
PMID:25682699
NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711
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Il12a
interleukin 12a
increases expression
ISO
Zearalenone results in increased expression of IL12A mRNA
CTD
PMID:36828454
NCBI chr 3:68,597,977...68,605,881
Ensembl chr 3:68,597,977...68,605,880
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Il13
interleukin 13
increases expression
ISO
Zearalenone results in increased expression of IL13 mRNA
CTD
PMID:27757495
NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529
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Il18
interleukin 18
multiple interactions increases expression increases secretion
EXP
[Dextran Sulfate co-treated with Zearalenone] results in increased expression of IL18 mRNA; [Dextran Sulfate co-treated with Zearalenone] results in increased secretion of IL18 protein; Dextran Sulfate inhibits the reaction [Zearalenone results in increased secretion of IL18 protein]; Nicotinamide Mononucleotide inhibits the reaction [Zearalenone results in increased expression of IL18 mRNA]; Zearalenone inhibits the reaction [Dextran Sulfate results in increased expression of IL18 mRNA]; Zearalenone inhibits the reaction [Dextran Sulfate results in increased secretion of IL18 protein]
CTD
PMID:30270565 PMID:38159578
NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140
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Il1b
interleukin 1 beta
multiple interactions increases expression increases secretion
EXP ISO
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [corynoline inhibits the reaction [Zearalenone results in increased expression of IL1B protein]]; [Dextran Sulfate co-treated with Zearalenone] results in increased secretion of IL1B protein; corynoline inhibits the reaction [Zearalenone results in increased expression of IL1B protein]; Lipopolysaccharides promotes the reaction [Zearalenone results in increased expression of IL1B mRNA]; Lycopene inhibits the reaction [Zearalenone results in increased expression of IL1B]; Nicotinamide Mononucleotide inhibits the reaction [Zearalenone results in increased expression of IL1B mRNA]; Zearalenone inhibits the reaction [Dextran Sulfate results in increased secretion of IL1B protein] Zearalenone results in increased expression of IL1B; Zearalenone results in increased expression of IL1B mRNA; Zearalenone results in increased expression of IL1B protein Zearalenone results in increased secretion of IL1B protein 3-methyladenine promotes the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of IL1B protein modified form]; [Zearalenone co-treated with Lipopolysaccharides] results in increased expression of IL1B mRNA; [Zearalenone co-treated with Lipopolysaccharides] results in increased expression of IL1B protein; [Zearalenone co-treated with Lipopolysaccharides] results in increased expression of IL1B protein modified form; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of IL1B mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of IL1B protein modified form]; NLRP3 protein promotes the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of IL1B protein modified form]; pyrrolidine dithiocarbamic acid inhibits the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of IL1B mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Zearalenone results in increased expression of IL1B protein modified form]; Sirolimus inhibits the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of IL1B protein modified form] [Zearalenone co-treated with deoxynivalenol] results in increased expression of IL1B mRNA
CTD
PMID:16687389 PMID:25682699 PMID:30270565 PMID:31586597 PMID:35090964 PMID:36161741 PMID:38159578 More...
NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
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Il1rn
interleukin 1 receptor antagonist
decreases expression
ISO
Zearalenone results in decreased expression of IL1RN mRNA
CTD
PMID:36828454
NCBI chr 2:24,226,872...24,241,503
Ensembl chr 2:24,226,865...24,241,506
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Il2
interleukin 2
multiple interactions increases expression
EXP
lycopene inhibits the reaction [Zearalenone results in increased expression of IL2]
CTD
PMID:25682699
NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108
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Il4
interleukin 4
increases expression
ISO
Zearalenone results in increased expression of IL4 mRNA
CTD
PMID:27757495
NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496
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Il4ra
interleukin 4 receptor, alpha
increases expression
ISO
Zearalenone results in increased expression of IL4R mRNA
CTD
PMID:19371625
NCBI chr 7:125,151,443...125,178,646
Ensembl chr 7:125,151,292...125,178,646
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Il6
interleukin 6
multiple interactions increases expression
EXP ISO
Lipopolysaccharides promotes the reaction [Zearalenone results in increased expression of IL6 mRNA]; Lycopene inhibits the reaction [Zearalenone results in increased expression of IL6] [Lipopolysaccharides co-treated with Zearalenone] results in increased secretion of IL6 protein; [Zearalenone co-treated with Aflatoxin B1] results in decreased expression of IL6 mRNA; [Zearalenone co-treated with deoxynivalenol] results in increased expression of IL6 mRNA
CTD
PMID:16687389 PMID:25682699 PMID:28965971 PMID:32328699 PMID:35090964
NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
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Immt
inner membrane protein, mitochondrial
increases expression
EXP
Zearalenone results in increased expression of IMMT protein
CTD
PMID:25058043
NCBI chr 6:71,806,200...71,852,250
Ensembl chr 6:71,808,315...71,854,372
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Impdh2
inosine monophosphate dehydrogenase 2
increases expression
ISO
Zearalenone results in increased expression of IMPDH2 mRNA
CTD
PMID:19371625
NCBI chr 9:108,437,635...108,442,776
Ensembl chr 9:108,437,485...108,442,783
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Inhba
inhibin beta-A
decreases expression
EXP
Zearalenone results in decreased expression of INHBA mRNA
CTD
PMID:30138655
NCBI chr13:16,178,841...16,206,194
Ensembl chr13:16,186,436...16,206,206
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Ipo13
importin 13
increases expression
ISO
Zearalenone results in increased expression of IPO13 mRNA
CTD
PMID:19371625
NCBI chr 4:117,751,689...117,772,419
Ensembl chr 4:117,751,683...117,772,196
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Ism1
isthmin 1, angiogenesis inhibitor
increases expression
ISO
Zearalenone results in increased expression of ISM1 mRNA
CTD
PMID:36828454
NCBI chr 2:139,515,169...139,600,500
Ensembl chr 2:139,520,098...139,600,501
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Isyna1
myo-inositol 1-phosphate synthase A1
decreases expression
EXP
Zearalenone results in decreased expression of ISYNA1 protein
CTD
PMID:36252740
NCBI chr 8:71,047,131...71,049,940
Ensembl chr 8:71,047,023...71,049,940
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Itpk1
inositol 1,3,4-triphosphate 5/6 kinase
increases expression
ISO
Zearalenone results in increased expression of ITPK1 mRNA
CTD
PMID:19371625
NCBI chr12:102,534,842...102,671,128
Ensembl chr12:102,534,841...102,671,189
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Jag1
jagged 1
increases expression
EXP ISO
Zearalenone results in increased expression of JAG1 mRNA
CTD
PMID:30138655 PMID:32858132
NCBI chr 2:136,923,371...136,958,440
Ensembl chr 2:136,923,376...136,958,564
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Jun
jun proto-oncogene
multiple interactions increases expression
EXP
scutellarin inhibits the reaction [Zearalenone results in increased expression of JUN protein]
CTD
PMID:27473017 PMID:36252740
NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
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Kat2b
K(lysine) acetyltransferase 2B
increases expression
ISO
Zearalenone results in increased expression of KAT2B mRNA
CTD
PMID:32119988
NCBI chr17:53,873,802...53,979,749
Ensembl chr17:53,873,889...53,979,748
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Kazn
kazrin, periplakin interacting protein
increases expression
ISO
Zearalenone results in increased expression of KAZN mRNA
CTD
PMID:36828454
NCBI chr 4:141,829,701...142,801,231
Ensembl chr 4:141,829,701...142,205,056
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Kbtbd8
kelch repeat and BTB (POZ) domain containing 8
increases expression
ISO
Zearalenone results in increased expression of KBTBD8 mRNA
CTD
PMID:36828454
NCBI chr 6:95,094,861...95,106,774
Ensembl chr 6:95,094,221...95,106,771
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Kcnf1
potassium voltage-gated channel, subfamily F, member 1
increases expression
ISO
Zearalenone results in increased expression of KCNF1 mRNA
CTD
PMID:19371625 PMID:36828454
NCBI chr12:17,222,101...17,226,551
Ensembl chr12:17,222,101...17,226,889
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Kcnj2
potassium inwardly-rectifying channel, subfamily J, member 2
increases expression
ISO
Zearalenone results in increased expression of KCNJ2 mRNA
CTD
PMID:36828454
NCBI chr11:110,956,990...110,967,651
Ensembl chr11:110,956,990...110,967,647
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Kcnj5
potassium inwardly-rectifying channel, subfamily J, member 5
increases expression
ISO
Zearalenone results in increased expression of KCNJ5 mRNA
CTD
PMID:19371625
NCBI chr 9:32,226,002...32,255,640
Ensembl chr 9:32,226,003...32,255,646
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Kcnk15
potassium channel, subfamily K, member 15
increases expression
ISO
Zearalenone results in increased expression of KCNK15 mRNA
CTD
PMID:36828454
NCBI chr 2:163,695,670...163,700,794
Ensembl chr 2:163,695,571...163,701,666
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Kctd20
potassium channel tetramerisation domain containing 20
increases expression
ISO
Zearalenone results in increased expression of KCTD20 mRNA
CTD
PMID:19371625
NCBI chr17:29,171,420...29,188,523
Ensembl chr17:29,170,924...29,188,523
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Kdm4a
lysine (K)-specific demethylase 4A
decreases expression
EXP
Zearalenone results in decreased expression of KDM4A mRNA
CTD
PMID:24412631
NCBI chr 4:117,994,154...118,037,216
Ensembl chr 4:117,994,154...118,037,240
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Kitl
kit ligand
decreases expression
ISO
Zearalenone results in decreased expression of KITLG mRNA
CTD
PMID:27757495
NCBI chr10:99,851,477...99,936,278
Ensembl chr10:99,851,492...99,936,278
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Kmt5a
lysine methyltransferase 5A
increases expression
ISO
Zearalenone results in increased expression of KMT5A mRNA
CTD
PMID:32119988
NCBI chr 5:124,577,980...124,600,371
Ensembl chr 5:124,577,993...124,600,371
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Kras
Kirsten rat sarcoma viral oncogene homolog
increases expression decreases expression
EXP
Zearalenone results in increased expression of KRAS mRNA Zearalenone results in decreased expression of KRAS mRNA
CTD
PMID:29758222 PMID:30717214
NCBI chr 6:145,162,425...145,197,631
Ensembl chr 6:145,162,425...145,195,965
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Krt10
keratin 10
decreases expression
EXP
Zearalenone results in decreased expression of KRT10 protein
CTD
PMID:25058043
NCBI chr11:99,276,080...99,288,631
Ensembl chr11:99,276,080...99,280,190
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Krt17
keratin 17
decreases expression
ISO
Zearalenone results in decreased expression of KRT17 mRNA
CTD
PMID:19371625
NCBI chr11:100,147,041...100,151,855
Ensembl chr11:100,147,043...100,151,855
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Krt4
keratin 4
decreases expression
ISO
Zearalenone results in decreased expression of KRT4 mRNA
CTD
PMID:36828454
NCBI chr15:101,826,970...101,833,170
Ensembl chr15:101,826,970...101,833,170
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Krt5
keratin 5
increases expression
ISO
Zearalenone results in increased expression of KRT5 mRNA
CTD
PMID:28965971
NCBI chr15:101,615,504...101,621,340
Ensembl chr15:101,615,505...101,621,333
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Krt7
keratin 7
increases expression
ISO
Zearalenone results in increased expression of KRT7 mRNA
CTD
PMID:17557909
NCBI chr15:101,310,284...101,325,687
Ensembl chr15:101,308,924...101,328,194
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Ldlr
low density lipoprotein receptor
increases expression decreases expression
ISO
Zearalenone results in increased expression of LDLR mRNA Zearalenone results in decreased expression of LDLR mRNA; Zearalenone results in decreased expression of LDLR protein
CTD
PMID:32119988 PMID:32858132
NCBI chr 9:21,634,872...21,661,215
Ensembl chr 9:21,634,779...21,661,215
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Lefty2
left-right determination factor 2
decreases expression
ISO
Zearalenone results in decreased expression of LEFTY2 mRNA
CTD
PMID:19371625
NCBI chr 1:180,720,673...180,726,672
Ensembl chr 1:180,720,673...180,726,668
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Lgals1
lectin, galactose binding, soluble 1
decreases expression
ISO
Zearalenone results in decreased expression of LGALS1 mRNA
CTD
PMID:19371625
NCBI chr15:78,810,925...78,814,665
Ensembl chr15:78,810,925...78,814,665
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Lhb
luteinizing hormone beta
decreases expression multiple interactions
ISO
Zearalenone results in decreased expression of LHB protein Gallic Acid inhibits the reaction [Zearalenone results in decreased expression of LHB protein]
CTD
PMID:29627501 PMID:32858132 PMID:34723416
NCBI chr 7:45,070,370...45,071,278
Ensembl chr 7:45,070,244...45,071,321
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Lhcgr
luteinizing hormone/choriogonadotropin receptor
multiple interactions
EXP
[Colforsin co-treated with Zearalenone] results in increased expression of LHCGR mRNA
CTD
PMID:26783879
NCBI chr17:89,023,812...89,099,487
Ensembl chr17:89,023,909...89,099,418
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Lhx8
LIM homeobox protein 8
decreases expression
EXP
Zearalenone results in decreased expression of LHX8 mRNA; Zearalenone results in decreased expression of LHX8 protein
CTD
PMID:28089945
NCBI chr 3:154,011,925...154,036,190
Ensembl chr 3:154,011,931...154,036,296
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Lmna
lamin A
increases expression
EXP
Zearalenone results in increased expression of LMNA protein
CTD
PMID:36252740
NCBI chr 3:88,388,455...88,413,842
Ensembl chr 3:88,387,454...88,417,263
G
Lmnb1
lamin B1
increases expression
EXP
Zearalenone results in increased expression of LMNB1 protein
CTD
PMID:36252740
NCBI chr18:56,840,885...56,886,496
Ensembl chr18:56,840,885...56,886,496
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Lonrf2
LON peptidase N-terminal domain and ring finger 2
increases expression
ISO
Zearalenone results in increased expression of LONRF2 mRNA
CTD
PMID:36828454
NCBI chr 1:38,832,750...38,875,768
Ensembl chr 1:38,832,726...38,875,792
G
Lpin1
lipin 1
multiple interactions increases expression
EXP
Nicotinamide Mononucleotide inhibits the reaction [Zearalenone results in increased expression of LPIN1 protein]
CTD
PMID:38159578
NCBI chr12:16,585,670...16,697,020
Ensembl chr12:16,585,670...16,696,967
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Lrrc4
leucine rich repeat containing 4
decreases expression
ISO
Zearalenone results in decreased expression of LRRC4 mRNA
CTD
PMID:36828454
NCBI chr 6:28,828,125...28,831,746
Ensembl chr 6:28,661,830...28,831,746
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Lsp1
lymphocyte specific 1
decreases expression
ISO
Zearalenone results in decreased expression of LSP1 mRNA
CTD
PMID:17557909
NCBI chr 7:142,014,583...142,048,605
Ensembl chr 7:142,014,546...142,048,604
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Lyar
Ly1 antibody reactive clone
increases expression
ISO
Zearalenone results in increased expression of LYAR mRNA
CTD
PMID:36828454
NCBI chr 5:38,377,815...38,391,650
Ensembl chr 5:38,377,814...38,391,650
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Mak16
MAK16 homolog
increases expression
ISO
Zearalenone results in increased expression of RBM13 mRNA
CTD
PMID:19371625
NCBI chr 8:31,649,496...31,658,752
Ensembl chr 8:31,649,491...31,658,792
G
Map1lc3a
microtubule-associated protein 1 light chain 3 alpha
increases expression
EXP
Zearalenone results in increased expression of MAP1LC3A mRNA
CTD
PMID:34537261
NCBI chr 2:155,118,284...155,119,993
Ensembl chr 2:155,118,217...155,119,993
G
Map1lc3b
microtubule-associated protein 1 light chain 3 beta
increases expression
ISO EXP
Zearalenone results in increased expression of MAP1LC3B protein
CTD
PMID:31586597 PMID:32858132 PMID:34537261
NCBI chr 8:122,317,177...122,325,499
Ensembl chr 8:122,317,100...122,325,499
G
Map2k1
mitogen-activated protein kinase kinase 1
decreases expression
EXP
Zearalenone results in decreased expression of MAP2K1 protein
CTD
PMID:36252740
NCBI chr 9:64,093,066...64,160,887
Ensembl chr 9:64,093,052...64,160,913
G
Map2k4
mitogen-activated protein kinase kinase 4
multiple interactions decreases expression increases expression
EXP
scutellarin inhibits the reaction [Zearalenone results in increased expression of MAP2K4 protein] Zearalenone results in decreased expression of MAP2K4 protein
CTD
PMID:36252740
NCBI chr11:65,579,070...65,679,185
Ensembl chr11:65,579,069...65,679,123
G
Mapk1
mitogen-activated protein kinase 1
decreases phosphorylation multiple interactions increases phosphorylation
EXP ISO
Zearalenone results in decreased phosphorylation of MAPK1 protein HERPUD1 protein promotes the reaction [Zearalenone results in decreased phosphorylation of MAPK1 protein]; Nicotinamide Mononucleotide inhibits the reaction [Zearalenone results in increased phosphorylation of MAPK1 protein]; Zearalenone results in decreased expression of and results in decreased phosphorylation of MAPK1 protein
CTD
PMID:30394307 PMID:32858132 PMID:34716709 PMID:38159578
NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
G
Mapk13
mitogen-activated protein kinase 13
decreases expression
ISO
Zearalenone results in decreased expression of MAPK13 mRNA
CTD
PMID:19371625
NCBI chr17:28,988,260...28,997,678
Ensembl chr17:28,988,271...28,999,207
G
Mapk3
mitogen-activated protein kinase 3
decreases phosphorylation multiple interactions increases phosphorylation
EXP ISO
Zearalenone results in decreased phosphorylation of MAPK3 protein HERPUD1 protein promotes the reaction [Zearalenone results in decreased phosphorylation of MAPK3 protein]; Nicotinamide Mononucleotide inhibits the reaction [Zearalenone results in increased phosphorylation of MAPK3 protein]
CTD
PMID:30394307 PMID:32858132 PMID:38159578
NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
G
Mapk8
mitogen-activated protein kinase 8
increases phosphorylation increases expression
EXP
Zearalenone results in increased phosphorylation of MAPK8 protein Zearalenone results in increased expression of MAPK8 mRNA
CTD
PMID:21767629 PMID:30717214
NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115
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Mas1
MAS1 oncogene
increases expression
EXP
Zearalenone results in increased expression of MAS1 mRNA
CTD
PMID:24412631
NCBI chr17:13,056,981...13,087,037
Ensembl chr17:13,059,966...13,087,030
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Mat2b
methionine adenosyltransferase 2 non-catalytic beta subunit methionine
decreases expression
EXP
Zearalenone results in decreased expression of MAT2B protein
CTD
PMID:36252740
NCBI chr11:40,570,141...40,586,030
Ensembl chr11:40,570,141...40,586,030
G
Mdh2
malate dehydrogenase 2, NAD (mitochondrial)
increases expression
EXP
Zearalenone results in increased expression of MDH2 protein
CTD
PMID:25058043
NCBI chr 5:135,807,503...135,819,240
Ensembl chr 5:135,807,334...135,819,252
G
Mdk
midkine
decreases expression
ISO
Zearalenone results in decreased expression of MDK mRNA
CTD
PMID:19371625
NCBI chr 2:91,760,149...91,762,348
Ensembl chr 2:91,760,150...91,762,642
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Meox1
mesenchyme homeobox 1
decreases expression
ISO
Zearalenone results in decreased expression of MEOX1 mRNA
CTD
PMID:19371625
NCBI chr11:101,768,336...101,785,309
Ensembl chr11:101,768,336...101,785,200
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Met
met proto-oncogene
increases expression
ISO
Zearalenone results in increased expression of MET mRNA
CTD
PMID:19371625
NCBI chr 6:17,463,351...17,573,979
Ensembl chr 6:17,463,799...17,573,979
G
Mfap2
microfibrillar-associated protein 2
decreases expression
ISO
Zearalenone results in decreased expression of MFAP2 mRNA
CTD
PMID:36828454
NCBI chr 4:140,737,735...140,743,284
Ensembl chr 4:140,737,729...140,743,295
G
Mfge8
milk fat globule EGF and factor V/VIII domain containing
decreases expression
ISO
Zearalenone results in decreased expression of MFGE8 mRNA
CTD
PMID:19371625
NCBI chr 7:78,783,516...78,798,808
Ensembl chr 7:78,783,516...78,798,808
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Mfn2
mitofusin 2
increases expression
ISO
Zearalenone results in increased expression of MFN2 mRNA
CTD
PMID:19371625
NCBI chr 4:147,958,043...147,989,527
Ensembl chr 4:147,958,056...147,989,161
G
Mgat3
mannoside acetylglucosaminyltransferase 3
increases expression
ISO
Zearalenone results in increased expression of MGAT3 mRNA
CTD
PMID:36828454
NCBI chr15:80,057,852...80,099,720
Ensembl chr15:80,057,922...80,099,720
G
Mgll
monoglyceride lipase
multiple interactions
EXP
[Zearalenone co-treated with CGA protein] results in decreased expression of MGLL protein
CTD
PMID:25058043
NCBI chr 6:88,701,397...88,805,342
Ensembl chr 6:88,701,394...88,805,342
G
Mir146b
microRNA 146b
decreases expression
EXP
Zearalenone results in decreased expression of MIR146B mRNA
CTD
PMID:30717214
NCBI chr19:46,331,201...46,331,309
Ensembl chr19:46,331,201...46,331,309
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Mir185
microRNA 185
decreases expression
EXP
Zearalenone results in decreased expression of MIR185 mRNA
CTD
PMID:30717214
NCBI chr16:18,145,265...18,145,329
Ensembl chr16:18,145,265...18,145,329
G
Mir19a
microRNA 19a
increases expression
EXP
Zearalenone results in increased expression of MIR19A mRNA
CTD
PMID:30717214
NCBI chr14:115,281,432...115,281,513
Ensembl chr14:115,281,432...115,281,513
G
Mir200a
microRNA 200a
multiple interactions
ISO
Zearalenone results in decreased expression of and affects the secretion of MIR200A mRNA
CTD
PMID:33419253
NCBI chr 4:156,139,353...156,139,442
Ensembl chr 4:156,139,353...156,139,442
G
Mir200b
microRNA 200b
multiple interactions
ISO
Zearalenone results in decreased expression of and affects the secretion of MIR200B mRNA
CTD
PMID:33419253
NCBI chr 4:156,140,138...156,140,207
Ensembl chr 4:156,140,138...156,140,207
G
Mir200c
microRNA 200c
multiple interactions
ISO
Zearalenone results in increased expression of and results in decreased secretion of MIR200C mRNA
CTD
PMID:33419253
NCBI chr 6:124,695,285...124,695,353
Ensembl chr 6:124,695,285...124,695,353
G
Mir210
microRNA 210
decreases expression
EXP
Zearalenone results in decreased expression of MIR210 mRNA
CTD
PMID:30717214
NCBI chr 7:140,801,297...140,801,406
Ensembl chr 7:140,801,297...140,801,406
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Mir221
microRNA 221
increases expression multiple interactions
EXP ISO
Zearalenone results in increased expression of MIR221 mRNA [Zearalenone co-treated with deoxynivalenol] results in decreased expression of MIR221 mRNA
CTD
PMID:30717214 PMID:35090964
NCBI chr X:19,012,533...19,012,627
Ensembl chr X:19,012,533...19,012,627
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Mir301
microRNA 301
decreases expression
EXP
Zearalenone results in decreased expression of MIR301 mRNA
CTD
PMID:30717214
NCBI chr11:87,003,830...87,003,915
Ensembl chr11:87,003,830...87,003,915
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Mir3057
microRNA 3057
increases expression
EXP
Zearalenone results in increased expression of MIR3057 mRNA
CTD
PMID:30717214
NCBI chr10:81,107,431...81,107,521
Ensembl chr10:81,107,431...81,107,521
G
Mir3065
microRNA 3065
increases expression
ISO
Zearalenone results in increased expression of MIR3065 mRNA
CTD
PMID:36828454
NCBI chr11:119,905,593...119,905,679
Ensembl chr11:119,905,593...119,905,679
G
Mir3098
microRNA 3098
decreases expression
EXP
Zearalenone results in decreased expression of MIR3098 mRNA
CTD
PMID:30717214
NCBI chr 6:125,172,755...125,172,841
Ensembl chr 6:125,172,755...125,172,841
G
Mir326
microRNA 326
decreases expression
EXP
Zearalenone results in decreased expression of MIR326 mRNA
CTD
PMID:30717214
NCBI chr 7:99,201,476...99,201,570
Ensembl chr 7:99,201,476...99,201,570
G
Mir410
microRNA 410
decreases expression
EXP
Zearalenone results in decreased expression of MIR410 mRNA
CTD
PMID:30717214
NCBI chr12:109,710,149...109,710,229
Ensembl chr12:109,710,149...109,710,229
G
Mir411
microRNA 411
decreases expression
EXP
Zearalenone results in decreased expression of MIR411 mRNA
CTD
PMID:30717214
NCBI chr12:109,676,609...109,676,690
Ensembl chr12:109,676,609...109,676,690
G
Mir429
microRNA 429
decreases secretion
ISO
Zearalenone results in decreased secretion of MIR429 mRNA
CTD
PMID:33419253
NCBI chr 4:156,138,362...156,138,444
Ensembl chr 4:156,138,362...156,138,444
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Mir451a
microRNA 451a
increases expression
ISO
Zearalenone results in increased expression of MIR451A mRNA
CTD
PMID:36828454
NCBI chr11:77,963,996...77,964,067
Ensembl chr11:77,963,996...77,964,067
G
Mir467e
microRNA 467e
decreases expression
EXP
Zearalenone results in decreased expression of MIR467E mRNA
CTD
PMID:30717214
NCBI chr 2:10,510,532...10,510,618
Ensembl chr 2:10,510,532...10,510,618
G
Mir501
microRNA 501
decreases expression
ISO
Zearalenone results in decreased expression of MIR501 mRNA
CTD
PMID:36828454
NCBI chr X:7,107,482...7,107,590
Ensembl chr X:7,107,482...7,107,590
G
Mir615
microRNA 615
decreases expression
EXP
Zearalenone results in decreased expression of MIR615 mRNA
CTD
PMID:30717214
NCBI chr15:102,923,342...102,923,433
Ensembl chr15:102,923,342...102,923,433
G
Mir96
microRNA 96
affects expression
EXP
Zearalenone affects the expression of MIR96 mRNA
CTD
PMID:30717214
NCBI chr 6:30,169,445...30,169,550
Ensembl chr 6:30,169,445...30,169,550
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Mki67
antigen identified by monoclonal antibody Ki 67
increases expression
ISO
Zearalenone results in increased expression of MKI67 mRNA
CTD
PMID:28965971
NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090
G
Mlh1
mutL homolog 1
increases expression
EXP
Zearalenone results in increased expression of MLH1 mRNA; Zearalenone results in increased expression of MLH1 protein
CTD
PMID:28552778
NCBI chr 9:111,057,296...111,100,854
Ensembl chr 9:111,057,296...111,100,859
G
Mlph
melanophilin
increases expression
ISO
Zearalenone results in increased expression of MLPH mRNA
CTD
PMID:19371625
NCBI chr 1:90,842,750...90,878,864
Ensembl chr 1:90,842,807...90,878,864
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Mmp2
matrix metallopeptidase 2
increases expression
ISO
Zearalenone results in increased expression of MMP2 mRNA
CTD
PMID:28965971
NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048
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Mmp7
matrix metallopeptidase 7
increases expression
ISO
Zearalenone results in increased expression of MMP7 mRNA
CTD
PMID:17557909
NCBI chr 9:7,692,095...7,699,587
Ensembl chr 9:7,692,091...7,699,587
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Mpo
myeloperoxidase
increases secretion multiple interactions increases activity
EXP ISO
Zearalenone results in increased secretion of MPO protein 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [corynoline inhibits the reaction [Zearalenone results in increased activity of MPO protein]]; [Dextran Sulfate co-treated with Zearalenone] results in increased secretion of MPO protein; corynoline inhibits the reaction [Zearalenone results in increased activity of MPO protein]; Zearalenone inhibits the reaction [Dextran Sulfate results in increased secretion of MPO protein] Gallic Acid inhibits the reaction [Zearalenone results in increased activity of MPO protein]
CTD
PMID:30270565 PMID:34723416 PMID:36161741
NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239
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Msmb
beta-microseminoprotein
increases expression
ISO
Zearalenone results in increased expression of MSMB mRNA
CTD
PMID:19371625
NCBI chr14:31,863,980...31,880,284
Ensembl chr14:31,863,980...31,880,327
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mt-Atp6
ATP synthase 6, mitochondrial
multiple interactions decreases expression
ISO
[Plant Extracts co-treated with ochratoxin A co-treated with Zearalenone co-treated with beauvericin] results in decreased expression of ATP6 mRNA Zearalenone results in decreased expression of ATP6 mRNA
CTD
PMID:34015425
NCBI chr MT:7,927...8,607
Ensembl chr MT:7,927...8,607
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mt-Atp8
ATP synthase 8, mitochondrial
multiple interactions
ISO
[Plant Extracts co-treated with ochratoxin A co-treated with Zearalenone co-treated with beauvericin] results in decreased expression of ATP8 mRNA; [Plant Extracts co-treated with Zearalenone] results in decreased expression of ATP8 mRNA; [Zearalenone co-treated with ochratoxin A] results in decreased expression of ATP8 mRNA
CTD
PMID:34015425
NCBI chr MT:7,766...7,969
Ensembl chr MT:7,766...7,969
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mt-Co1
cytochrome c oxidase I, mitochondrial
decreases expression multiple interactions
ISO
Zearalenone results in decreased expression of COX1 mRNA [Plant Extracts co-treated with ochratoxin A co-treated with Zearalenone co-treated with beauvericin] results in decreased expression of COX1 mRNA; [Plant Extracts co-treated with ochratoxin A co-treated with Zearalenone] results in decreased expression of COX1 mRNA; [Plant Extracts co-treated with Zearalenone] results in decreased expression of COX1 mRNA; [Zearalenone co-treated with ochratoxin A] results in decreased expression of COX1 mRNA
CTD
PMID:34015425
NCBI chr MT:5,328...6,872
Ensembl chr MT:5,328...6,872
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mt-Co3
cytochrome c oxidase III, mitochondrial
decreases expression multiple interactions
ISO
Zearalenone results in decreased expression of COX3 mRNA [Plant Extracts co-treated with ochratoxin A co-treated with Zearalenone co-treated with beauvericin] results in decreased expression of COX3 mRNA; [Plant Extracts co-treated with ochratoxin A co-treated with Zearalenone] results in decreased expression of COX3 mRNA; [Plant Extracts co-treated with Zearalenone] results in decreased expression of COX3 mRNA; [Zearalenone co-treated with ochratoxin A] results in decreased expression of COX3 mRNA
CTD
PMID:34015425
NCBI chr MT:8,607...9,390
Ensembl chr MT:8,607...9,390
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mt-Nd2
NADH dehydrogenase 2, mitochondrial
multiple interactions
ISO
[Plant Extracts co-treated with ochratoxin A co-treated with Zearalenone co-treated with beauvericin] results in increased expression of ND2 mRNA; [Plant Extracts co-treated with ochratoxin A co-treated with Zearalenone] results in increased expression of ND2 mRNA; [Plant Extracts co-treated with Zearalenone] results in increased expression of ND2 mRNA; [Zearalenone co-treated with ochratoxin A] results in increased expression of ND2 mRNA
CTD
PMID:34015425
NCBI chr MT:3,914...4,951
Ensembl chr MT:3,914...4,951
G
mt-Nd3
NADH dehydrogenase 3, mitochondrial
multiple interactions
ISO
[Plant Extracts co-treated with ochratoxin A co-treated with Zearalenone co-treated with beauvericin] results in increased expression of ND3 mRNA; [Plant Extracts co-treated with ochratoxin A co-treated with Zearalenone] results in increased expression of ND3 mRNA; [Plant Extracts co-treated with Zearalenone] results in increased expression of ND3 mRNA; [Zearalenone co-treated with ochratoxin A] results in increased expression of ND3 mRNA
CTD
PMID:34015425
NCBI chr MT:9,459...9,806
Ensembl chr MT:9,459...9,806
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mt-Nd4
NADH dehydrogenase 4, mitochondrial
multiple interactions decreases expression
ISO
[Plant Extracts co-treated with ochratoxin A co-treated with Zearalenone co-treated with beauvericin] results in decreased expression of ND4 mRNA; [Plant Extracts co-treated with Zearalenone] results in increased expression of ND4 mRNA Zearalenone results in decreased expression of ND4 mRNA
CTD
PMID:34015425
NCBI chr MT:10,167...11,544
Ensembl chr MT:10,167...11,544
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mt-Nd4l
NADH dehydrogenase 4L, mitochondrial
multiple interactions
ISO
[Plant Extracts co-treated with Zearalenone] results in increased expression of ND4L mRNA; [Zearalenone co-treated with ochratoxin A] results in increased expression of ND4L mRNA
CTD
PMID:34015425
NCBI chr MT:9,877...10,173
Ensembl chr MT:9,877...10,173
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mt-Nd5
NADH dehydrogenase 5, mitochondrial
multiple interactions
ISO
[Plant Extracts co-treated with ochratoxin A co-treated with Zearalenone] results in increased expression of ND5 mRNA; [Plant Extracts co-treated with Zearalenone] results in increased expression of ND5 mRNA; [Zearalenone co-treated with ochratoxin A] results in increased expression of ND5 mRNA
CTD
PMID:34015425
NCBI chr MT:11,742...13,565
Ensembl chr MT:11,742...13,565
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mt-Nd6
NADH dehydrogenase 6, mitochondrial
decreases expression multiple interactions
ISO
Zearalenone results in decreased expression of ND6 mRNA [Plant Extracts co-treated with ochratoxin A co-treated with Zearalenone] results in increased expression of ND6 mRNA; [Plant Extracts co-treated with Zearalenone] results in increased expression of ND6 mRNA; [Zearalenone co-treated with ochratoxin A] results in increased expression of ND6 mRNA
CTD
PMID:34015425
NCBI chr MT:13,552...14,070
Ensembl chr MT:13,552...14,070
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mt-Rnr2
16S rRNA, mitochondrial
decreases expression multiple interactions
ISO
Zearalenone results in decreased expression of RNR2 mRNA [Plant Extracts co-treated with ochratoxin A co-treated with Zearalenone co-treated with beauvericin] results in decreased expression of RNR2 mRNA; [Plant Extracts co-treated with ochratoxin A co-treated with Zearalenone] results in decreased expression of RNR2 mRNA; [Plant Extracts co-treated with Zearalenone] results in decreased expression of RNR2 mRNA; [Zearalenone co-treated with ochratoxin A] results in decreased expression of RNR2 mRNA
CTD
PMID:34015425
NCBI chr MT:1,094...2,675
Ensembl chr MT:1,094...2,675
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Mtarc2
mitochondrial amidoxime reducing component 2
increases expression
EXP
Zearalenone results in increased expression of MTARC2 protein
CTD
PMID:25058043
NCBI chr 1:184,545,263...184,579,266
Ensembl chr 1:184,545,265...184,578,648
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Mthfd1l
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
increases expression
EXP
Zearalenone results in increased expression of MTHFD1L protein
CTD
PMID:25058043
NCBI chr10:3,918,282...4,117,081
Ensembl chr10:3,923,118...4,117,081
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Mtor
mechanistic target of rapamycin kinase
decreases phosphorylation multiple interactions
ISO EXP
Zearalenone results in decreased phosphorylation of MTOR protein 2-aminoethyl diphenylborinate inhibits the reaction [Zearalenone results in decreased phosphorylation of MTOR protein]; acadesine promotes the reaction [Zearalenone results in decreased phosphorylation of MTOR protein]; Acetylcysteine inhibits the reaction [Zearalenone results in decreased phosphorylation of MTOR protein]; dorsomorphin inhibits the reaction [Zearalenone results in decreased phosphorylation of MTOR protein]
CTD
PMID:31586597 PMID:31982503 PMID:32858132
NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140
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Muc2
mucin 2
multiple interactions
ISO
[Aflatoxin M1 co-treated with Zearalenone co-treated with ochratoxin A] results in decreased expression of MUC2 mRNA; [Aflatoxin M1 co-treated with Zearalenone co-treated with ochratoxin A] results in decreased secretion of MUC2 protein; [Aflatoxin M1 co-treated with Zearalenone] results in decreased expression of MUC2 mRNA; [Aflatoxin M1 co-treated with Zearalenone] results in decreased secretion of MUC2 protein
CTD
PMID:30904571
NCBI chr 7:141,276,583...141,308,428
Ensembl chr 7:141,276,583...141,308,430
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Muc4
mucin 4
increases expression
ISO
Zearalenone results in increased expression of MUC4 mRNA
CTD
PMID:17557909
NCBI chr16:32,555,089...32,602,786
Ensembl chr16:32,555,015...32,602,754
G
Muc5ac
mucin 5, subtypes A and C, tracheobronchial/gastric
increases expression multiple interactions
ISO
Zearalenone results in increased expression of MUC5AC mRNA [Aflatoxin M1 co-treated with Zearalenone co-treated with ochratoxin A] results in decreased expression of MUC5AC mRNA; [Aflatoxin M1 co-treated with Zearalenone co-treated with ochratoxin A] results in increased secretion of MUC5AC protein; [Aflatoxin M1 co-treated with Zearalenone] results in decreased expression of MUC5AC mRNA; Zearalenone results in increased expression of and results in increased secretion of MUC5AC protein
CTD
PMID:24496642 PMID:30904571
NCBI chr 7:141,342,695...141,372,964
Ensembl chr 7:141,342,709...141,372,968
G
Muc5b
mucin 5, subtype B, tracheobronchial
multiple interactions increases expression
ISO
[Aflatoxin M1 co-treated with Zearalenone co-treated with ochratoxin A] results in decreased expression of MUC5B mRNA; [Aflatoxin M1 co-treated with Zearalenone co-treated with ochratoxin A] results in decreased secretion of MUC5B protein; [Aflatoxin M1 co-treated with Zearalenone] results in decreased expression of MUC5B mRNA; [Aflatoxin M1 co-treated with Zearalenone] results in decreased secretion of MUC5B protein; Zearalenone results in increased expression of and results in increased secretion of MUC5B protein Zearalenone results in increased expression of MUC5B mRNA
CTD
PMID:24496642 PMID:30904571
NCBI chr 7:141,392,796...141,426,826
Ensembl chr 7:141,392,807...141,426,821
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Myc
myelocytomatosis oncogene
increases expression
ISO EXP
Zearalenone results in increased expression of MYC mRNA Zearalenone results in increased expression of MYC protein
CTD
PMID:27473017 PMID:28965971 PMID:36828454
NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223
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Myd88
myeloid differentiation primary response gene 88
increases expression
ISO
Zearalenone results in increased expression of MYD88 mRNA
CTD
PMID:27757495
NCBI chr 9:119,165,000...119,169,084
Ensembl chr 9:119,165,000...119,170,477
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N4bp3
NEDD4 binding protein 3
decreases expression
ISO
Zearalenone results in decreased expression of N4BP3 mRNA
CTD
PMID:36828454
NCBI chr11:51,533,908...51,541,664
Ensembl chr11:51,533,890...51,541,669
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Naa10
N(alpha)-acetyltransferase 10, NatA catalytic subunit
decreases expression
EXP
Zearalenone results in decreased expression of NAA10 protein
CTD
PMID:36252740
NCBI chr X:72,960,476...72,965,550
Ensembl chr X:72,960,479...72,965,550
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Nars1
asparaginyl-tRNA synthetase 1
decreases expression
EXP
Zearalenone results in decreased expression of NARS1 protein
CTD
PMID:36252740
NCBI chr18:64,632,726...64,649,586
Ensembl chr18:64,632,718...64,649,723
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Nasp
nuclear autoantigenic sperm protein (histone-binding)
decreases expression
ISO
Zearalenone results in decreased expression of NASP mRNA
CTD
PMID:17557909
NCBI chr 4:116,458,249...116,488,894
Ensembl chr 4:116,458,249...116,485,138
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Ncmap
noncompact myelin associated protein
increases expression
ISO
Zearalenone results in increased expression of NCMAP mRNA
CTD
PMID:19371625
NCBI chr 4:135,096,887...135,125,551
Ensembl chr 4:135,096,887...135,125,538
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Ncoa2
nuclear receptor coactivator 2
multiple interactions
ISO
Zearalenone analog promotes the reaction [ESR1 protein binds to and results in increased activity of NCOA2 protein]; Zearalenone analog promotes the reaction [ESR2 protein binds to and results in increased activity of NCOA2 protein]; Zearalenone promotes the reaction [ESR1 protein binds to and results in increased activity of NCOA2 protein]; Zearalenone promotes the reaction [ESR2 protein binds to and results in increased activity of NCOA2 protein]; Zearalenone promotes the reaction [NCOA2 protein binds to ESR1 protein]
CTD
PMID:15084758 PMID:28807876
NCBI chr 1:13,209,329...13,444,451
Ensembl chr 1:13,209,329...13,444,307
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Ndrg1
N-myc downstream regulated gene 1
decreases expression
ISO
Zearalenone results in decreased expression of NDRG1 mRNA
CTD
PMID:36828454
NCBI chr15:66,801,167...66,841,490
Ensembl chr15:66,801,167...66,841,489
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Nectin4
nectin cell adhesion molecule 4
decreases expression
ISO
Zearalenone results in decreased expression of NECTIN4 mRNA
CTD
PMID:36828454
NCBI chr 1:171,197,741...171,215,855
Ensembl chr 1:171,197,667...171,216,166
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Neil2
nei like 2 (E. coli)
increases expression
ISO
Zearalenone results in increased expression of NEIL2 mRNA
CTD
PMID:19371625
NCBI chr14:63,419,888...63,431,604
Ensembl chr14:63,419,892...63,431,305
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Nfe2l2
nuclear factor, erythroid derived 2, like 2
multiple interactions increases expression
EXP
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [corynoline promotes the reaction [Zearalenone results in increased expression of NFE2L2 protein]]; corynoline promotes the reaction [Zearalenone results in increased expression of NFE2L2 protein]
CTD
PMID:36161741
NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
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Nfkbia
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
increases phosphorylation multiple interactions
ISO EXP
Zearalenone results in increased phosphorylation of NFKBIA protein 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [corynoline inhibits the reaction [Zearalenone results in increased phosphorylation of NFKBIA protein]]; corynoline inhibits the reaction [Zearalenone results in increased phosphorylation of NFKBIA protein]
CTD
PMID:31586597 PMID:36161741
NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432
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Ngef
neuronal guanine nucleotide exchange factor
decreases expression
ISO
Zearalenone results in decreased expression of NGEF mRNA
CTD
PMID:19371625
NCBI chr 1:87,404,551...87,501,661
Ensembl chr 1:87,404,556...87,501,592
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Niban2
niban apoptosis regulator 2
decreases expression
ISO
Zearalenone results in decreased expression of NIBAN2 mRNA
CTD
PMID:19371625
NCBI chr 2:32,766,146...32,815,265
Ensembl chr 2:32,766,126...32,815,266
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Nlrp3
NLR family, pyrin domain containing 3
increases expression multiple interactions
EXP ISO
Zearalenone results in increased expression of NLRP3 mRNA; Zearalenone results in increased expression of NLRP3 protein [Dextran Sulfate co-treated with Zearalenone] results in increased expression of NLRP3 mRNA; [Dextran Sulfate co-treated with Zearalenone] results in increased expression of NLRP3 protein; Dextran Sulfate inhibits the reaction [Zearalenone results in increased expression of NLRP3 mRNA]; Zearalenone inhibits the reaction [Dextran Sulfate results in increased expression of NLRP3 mRNA]; Zearalenone inhibits the reaction [Dextran Sulfate results in increased expression of NLRP3 protein] NLRP3 protein promotes the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of CASP1 protein modified form]; NLRP3 protein promotes the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of IL1B protein modified form]; NLRP3 protein promotes the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of TNF protein]
CTD
PMID:30270565 PMID:31586597
NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782
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Nme1
NME/NM23 nucleoside diphosphate kinase 1
increases expression
ISO
Zearalenone results in increased expression of NME1 mRNA
CTD
PMID:28965971
NCBI chr11:93,849,751...93,859,341
Ensembl chr11:93,847,805...93,859,347
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Nmnat1
nicotinamide nucleotide adenylyltransferase 1
decreases expression
EXP
Zearalenone results in decreased expression of NMNAT1 mRNA
CTD
PMID:38159578
NCBI chr 4:149,552,026...149,569,667
Ensembl chr 4:149,552,029...149,569,659
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Nmnat2
nicotinamide nucleotide adenylyltransferase 2
decreases expression
EXP
Zearalenone results in decreased expression of NMNAT2 mRNA
CTD
PMID:38159578
NCBI chr 1:152,830,532...152,995,012
Ensembl chr 1:152,830,744...152,995,007
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Nmral1
NmrA-like family domain containing 1
decreases expression
EXP
Zearalenone results in decreased expression of NMRAL1 protein
CTD
PMID:36252740
NCBI chr16:4,529,181...4,537,220
Ensembl chr16:4,527,923...4,537,220
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Nobox
NOBOX oogenesis homeobox
decreases expression
EXP
Zearalenone results in decreased expression of NOBOX mRNA
CTD
PMID:28089945
NCBI chr 6:43,280,608...43,287,006
Ensembl chr 6:43,280,608...43,286,488
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Notch1
notch 1
multiple interactions
ISO
[Zearalenone co-treated with Aflatoxin B1] results in increased expression of NOTCH1 mRNA
CTD
PMID:28965971
NCBI chr 2:26,347,914...26,393,834
Ensembl chr 2:26,347,915...26,406,675
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Npy1r
neuropeptide Y receptor Y1
increases expression
ISO
Zearalenone results in increased expression of NPY1R mRNA
CTD
PMID:36828454
NCBI chr 8:67,149,595...67,159,452
Ensembl chr 8:67,149,844...67,159,444
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Nr1h3
nuclear receptor subfamily 1, group H, member 3
increases expression
ISO EXP
Zearalenone results in increased expression of NR1H3 mRNA
CTD
PMID:32119988 PMID:38159578
NCBI chr 2:91,014,406...91,033,189
Ensembl chr 2:91,014,406...91,033,179
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
increases activity decreases expression multiple interactions affects binding
ISO
Zearalenone results in increased activity of NR1I2 protein Zearalenone results in decreased expression of NR1I2 mRNA Zearalenone binds to and results in increased activity of NR1I2 protein; Zearalenone promotes the reaction [NR1I2 protein results in increased expression of CYP3A4] Zearalenone binds to NR1I2 protein
CTD
PMID:15569515 PMID:20607812 PMID:33049310 PMID:36893891
NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186
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Nr1i3
nuclear receptor subfamily 1, group I, member 3
increases activity
ISO
Zearalenone results in increased activity of NR1I3 protein
CTD
PMID:28927721
NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270
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Nr3c1
nuclear receptor subfamily 3, group C, member 1
decreases expression
ISO
Zearalenone results in decreased expression of NR3C1 mRNA
CTD
PMID:28965971
NCBI chr18:39,543,598...39,652,485
Ensembl chr18:39,543,598...39,652,474
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Nr4a1
nuclear receptor subfamily 4, group A, member 1
decreases expression multiple interactions increases expression
EXP
Zearalenone results in decreased expression of NR4A1 protein Colforsin promotes the reaction [Zearalenone results in increased expression of NR4A1 mRNA]
CTD
PMID:24512812 PMID:26783879
NCBI chr15:101,151,783...101,172,676
Ensembl chr15:101,152,150...101,172,676
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Nr5a1
nuclear receptor subfamily 5, group A, member 1
decreases expression
ISO
Zearalenone results in decreased expression of NR5A1 mRNA; Zearalenone results in decreased expression of NR5A1 protein
CTD
PMID:29669061
NCBI chr 2:38,582,668...38,604,554
Ensembl chr 2:38,582,668...38,604,554
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Nrip1
nuclear receptor interacting protein 1
increases expression
ISO
Zearalenone results in increased expression of NRIP1 mRNA
CTD
PMID:19371625
NCBI chr16:76,084,291...76,170,930
Ensembl chr16:76,084,288...76,170,715
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Nrtn
neurturin
increases expression
ISO
Zearalenone results in increased expression of NRTN mRNA
CTD
PMID:19371625
NCBI chr17:57,058,323...57,064,548
Ensembl chr17:57,058,325...57,064,530
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Nt5c
5',3'-nucleotidase, cytosolic
decreases expression
EXP
Zearalenone results in decreased expression of NT5C protein
CTD
PMID:36252740
NCBI chr11:115,381,251...115,382,659
Ensembl chr11:115,381,246...115,382,688
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Nubp2
nucleotide binding protein 2
decreases expression
EXP
Zearalenone results in decreased expression of NUBP2 protein
CTD
PMID:36252740
NCBI chr17:25,101,585...25,105,423
Ensembl chr17:25,101,585...25,105,323
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Nucb2
nucleobindin 2
increases expression
EXP
Zearalenone results in increased expression of NUCB2 protein
CTD
PMID:36252740
NCBI chr 7:116,103,579...116,139,823
Ensembl chr 7:116,103,604...116,139,819
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Nudcd2
NudC domain containing 2
decreases expression
EXP
Zearalenone results in decreased expression of NUDCD2 protein
CTD
PMID:36252740
NCBI chr11:40,624,485...40,630,873
Ensembl chr11:40,624,494...40,630,873
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Nudt5
nudix hydrolase 5
decreases expression
EXP
Zearalenone results in decreased expression of NUDT5 protein
CTD
PMID:36252740
NCBI chr 2:5,849,839...5,875,631
Ensembl chr 2:5,849,830...5,876,706
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Nxnl2
nucleoredoxin-like 2
increases expression
ISO
Zearalenone results in increased expression of NXNL2 mRNA
CTD
PMID:36828454
NCBI chr13:51,324,256...51,329,227
Ensembl chr13:51,325,058...51,329,224
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Oas1e
2'-5' oligoadenylate synthetase 1E
decreases expression
ISO
Zearalenone results in decreased expression of SNHG32 mRNA
CTD
PMID:19371625
NCBI chr 5:120,924,377...120,933,595
Ensembl chr 5:120,924,291...120,933,595
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Odaph
odontogenesis associated phosphoprotein
decreases expression
ISO
Zearalenone results in decreased expression of ODAPH mRNA
CTD
PMID:36828454
NCBI chr 5:92,135,332...92,143,176
Ensembl chr 5:92,135,334...92,143,179
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Olfm1
olfactomedin 1
increases expression
ISO
Zearalenone results in increased expression of OLFM1 mRNA
CTD
PMID:19371625 PMID:36828454
NCBI chr 2:28,083,105...28,120,748
Ensembl chr 2:28,083,004...28,120,748
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Olfml3
olfactomedin-like 3
increases expression
ISO
Zearalenone results in increased expression of OLFML3 mRNA
CTD
PMID:19371625 PMID:36828454
NCBI chr 3:103,642,710...103,645,317
Ensembl chr 3:103,629,538...103,645,317
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Osgin1
oxidative stress induced growth inhibitor 1
increases expression multiple interactions
ISO
Zearalenone results in increased expression of OSGIN1 mRNA [Zearalenone co-treated with ochratoxin A] results in increased expression of OSGIN1 mRNA
CTD
PMID:34015425
NCBI chr 8:120,160,874...120,172,996
Ensembl chr 8:120,160,863...120,172,995
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Oxsr1
oxidative-stress responsive 1
decreases expression
EXP
Zearalenone results in decreased expression of OXSR1 protein
CTD
PMID:36252740
NCBI chr 9:119,067,498...119,154,475
Ensembl chr 9:119,067,498...119,151,493
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P4hb
prolyl 4-hydroxylase, beta polypeptide
multiple interactions
EXP
[Zearalenone co-treated with CGA protein] results in decreased expression of P4HB protein
CTD
PMID:25058043
NCBI chr11:120,451,124...120,464,079
Ensembl chr11:120,451,124...120,464,079
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Pafah1b2
platelet-activating factor acetylhydrolase, isoform 1b, subunit 2
decreases expression
EXP
Zearalenone results in decreased expression of PAFAH1B2 protein
CTD
PMID:36252740
NCBI chr 9:45,876,609...45,923,988
Ensembl chr 9:45,874,157...45,923,988
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Pafah1b3
platelet-activating factor acetylhydrolase, isoform 1b, subunit 3
decreases expression
EXP
Zearalenone results in decreased expression of PAFAH1B3 protein
CTD
PMID:36252740
NCBI chr 7:24,994,473...24,997,377
Ensembl chr 7:24,994,474...24,997,411
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Paics
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase
decreases expression
EXP
Zearalenone results in decreased expression of PAICS protein
CTD
PMID:25058043
NCBI chr 5:77,099,149...77,115,356
Ensembl chr 5:77,099,154...77,115,356
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Pak2
p21 (RAC1) activated kinase 2
decreases expression
EXP
Zearalenone results in decreased expression of PAK2 protein
CTD
PMID:36252740
NCBI chr16:31,835,108...31,898,160
Ensembl chr16:31,835,108...31,898,160
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Palm3
paralemmin 3
decreases expression
ISO
Zearalenone results in decreased expression of PALM3 mRNA
CTD
PMID:36828454
NCBI chr 8:84,747,787...84,757,300
Ensembl chr 8:84,748,100...84,756,924
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Parp1
poly (ADP-ribose) polymerase family, member 1
increases cleavage decreases expression multiple interactions increases expression
ISO EXP
Zearalenone results in increased cleavage of PARP1 protein Zearalenone results in decreased expression of PARP1 protein Nicotinamide Mononucleotide inhibits the reaction [Zearalenone results in increased expression of PARP1 mRNA]
CTD
PMID:24530352 PMID:28089945 PMID:38159578
NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
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Pbdc1
polysaccharide biosynthesis domain containing 1
decreases expression
EXP
Zearalenone results in decreased expression of PBDC1 protein
CTD
PMID:36252740
NCBI chr X:104,123,337...104,160,696
Ensembl chr X:104,123,362...104,160,696
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Pck2
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
increases expression
EXP
Zearalenone results in increased expression of PCK2 protein
CTD
PMID:25058043
NCBI chr14:55,777,721...55,787,477
Ensembl chr14:55,777,723...55,788,699
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Pclaf
PCNA clamp associated factor
decreases expression
ISO
Zearalenone results in decreased expression of PCLAF mRNA
CTD
PMID:19371625
NCBI chr 9:65,797,605...65,810,833
Ensembl chr 9:65,797,519...65,810,548
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Pcx
pyruvate carboxylase
increases expression decreases expression
EXP ISO
Zearalenone results in increased expression of PCX protein Zearalenone results in decreased expression of PC mRNA; Zearalenone results in decreased expression of PC protein
CTD
PMID:25058043 PMID:32858132
NCBI chr19:4,560,500...4,671,780
Ensembl chr19:4,560,500...4,671,780
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Pdcd1
programmed cell death 1
increases expression
ISO
Zearalenone results in increased expression of PDCD1 mRNA
CTD
PMID:27757495
NCBI chr 1:93,966,027...93,980,278
Ensembl chr 1:93,966,027...93,980,278
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Pdcd6ip
programmed cell death 6 interacting protein
multiple interactions
EXP
[Zearalenone co-treated with CGA protein] results in increased expression of PDCD6IP protein
CTD
PMID:25058043
NCBI chr 9:113,480,812...113,537,457
Ensembl chr 9:113,480,812...113,537,327
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Pdcd7
programmed cell death 7
increases expression
ISO
Zearalenone results in increased expression of PDCD7 mRNA
CTD
PMID:19371625
NCBI chr 9:65,253,350...65,266,925
Ensembl chr 9:65,253,386...65,266,925
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Pde3b
phosphodiesterase 3B, cGMP-inhibited
increases expression
ISO
Zearalenone results in increased expression of PDE3B mRNA
CTD
PMID:36828454
NCBI chr 7:114,014,388...114,137,173
Ensembl chr 7:114,014,516...114,138,486
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Pdgfrl
platelet-derived growth factor receptor-like
increases expression
ISO
Zearalenone results in increased expression of PDGFRL mRNA
CTD
PMID:36828454
NCBI chr 8:41,379,270...41,443,819
Ensembl chr 8:41,379,249...41,443,822
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Pdha1
pyruvate dehydrogenase E1 alpha 1
increases expression
EXP
Zearalenone results in increased expression of PDHA1 protein
CTD
PMID:25058043
NCBI chr X:158,905,215...158,921,426
Ensembl chr X:158,905,205...158,921,409
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Pdxdc1
pyridoxal-dependent decarboxylase domain containing 1
decreases expression
EXP
Zearalenone results in decreased expression of PDXDC1 protein
CTD
PMID:36252740
NCBI chr16:13,651,025...13,721,018
Ensembl chr16:13,651,012...13,720,995
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Pfkfb2
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
decreases expression
ISO
Zearalenone results in decreased expression of PFKFB2 mRNA
CTD
PMID:19371625
NCBI chr 1:130,616,780...130,656,990
Ensembl chr 1:130,616,919...130,656,990 Ensembl chr 1:130,616,919...130,656,990
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Pfkl
phosphofructokinase, liver, B-type
decreases expression
EXP
Zearalenone results in decreased expression of PFKL protein
CTD
PMID:36252740
NCBI chr10:77,822,781...77,845,641
Ensembl chr10:77,822,781...77,845,917
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Pgd
phosphogluconate dehydrogenase
decreases expression
EXP
Zearalenone results in decreased expression of PGD protein
CTD
PMID:25058043
NCBI chr 4:149,234,448...149,251,162
Ensembl chr 4:149,234,448...149,251,228
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Pgk1
phosphoglycerate kinase 1
decreases expression multiple interactions
EXP
Zearalenone results in decreased expression of PGK1 protein Nicotinamide Mononucleotide inhibits the reaction [Zearalenone results in decreased expression of PGK1 protein]
CTD
PMID:25058043 PMID:36252740 PMID:38159578
NCBI chr X:105,230,706...105,247,305
Ensembl chr X:105,230,706...105,247,305
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Pgpep1
pyroglutamyl-peptidase I
decreases expression
EXP
Zearalenone results in decreased expression of PGPEP1 protein
CTD
PMID:36252740
NCBI chr 8:71,099,086...71,113,096
Ensembl chr 8:71,099,085...71,113,038
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Pgr
progesterone receptor
increases expression multiple interactions
ISO
Zearalenone results in increased expression of PGR mRNA; Zearalenone results in increased expression of PGR protein deoxynivalenol promotes the reaction [Zearalenone results in increased expression of PGR mRNA]; Fulvestrant inhibits the reaction [Zearalenone results in increased expression of PGR protein]; PPARG inhibits the reaction [Zearalenone results in increased expression of PGR mRNA]; Zearalenone inhibits the reaction [Progesterone binds to and results in increased activity of PGR protein]
CTD
PMID:19371625 PMID:21803136 PMID:28807876 PMID:28965971 PMID:35588983
NCBI chr 9:8,890,017...8,968,612
Ensembl chr 9:8,899,834...8,968,612
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Phb1
prohibitin 1
increases expression
EXP
Zearalenone results in increased expression of PHB1 protein
CTD
PMID:25058043
NCBI chr11:95,557,783...95,571,599
Ensembl chr11:95,557,783...95,571,599
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Phb2
prohibitin 2
increases expression
EXP
Zearalenone results in increased expression of PHB2 protein
CTD
PMID:25058043
NCBI chr 6:124,689,252...124,693,908
Ensembl chr 6:124,689,299...124,693,913
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Phf11d
PHD finger protein 11D
decreases expression
ISO
Zearalenone results in decreased expression of PHF11 mRNA
CTD
PMID:19371625
NCBI chr14:59,584,646...59,608,004
Ensembl chr14:59,584,856...59,602,919
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Phgdh
3-phosphoglycerate dehydrogenase
multiple interactions decreases expression
EXP
[Zearalenone co-treated with CGA protein] results in increased expression of PHGDH protein Zearalenone results in decreased expression of PHGDH protein
CTD
PMID:25058043 PMID:36252740
NCBI chr 3:98,220,487...98,247,285
Ensembl chr 3:98,220,486...98,247,306
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Pik3cd
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
increases expression
EXP
Zearalenone results in increased expression of PIK3CD mRNA
CTD
PMID:30138655
NCBI chr 4:149,733,625...149,787,023
Ensembl chr 4:149,733,625...149,787,028
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Pim1
proviral integration site 1
increases expression
ISO
Zearalenone results in increased expression of PIM1 mRNA
CTD
PMID:19371625
NCBI chr17:29,709,759...29,715,085
Ensembl chr17:29,709,727...29,715,086
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Pipox
pipecolic acid oxidase
increases expression
ISO
Zearalenone results in increased expression of PIPOX mRNA
CTD
PMID:36828454
NCBI chr11:77,771,440...77,784,698
Ensembl chr11:77,771,441...77,784,922
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Piwil1
piwi-like RNA-mediated gene silencing 1
decreases expression
EXP
Zearalenone results in decreased expression of PIWIL1 protein
CTD
PMID:31419471
NCBI chr 5:128,813,135...128,832,538
Ensembl chr 5:128,779,588...128,832,538
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Pkdcc
protein kinase domain containing, cytoplasmic
increases expression
ISO
Zearalenone results in increased expression of PKDCC mRNA
CTD
PMID:36828454
NCBI chr17:83,522,708...83,532,496
Ensembl chr17:83,522,721...83,532,499
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Plat
plasminogen activator, tissue
increases expression
ISO
Zearalenone results in increased expression of PLAT mRNA
CTD
PMID:36828454
NCBI chr 8:23,247,655...23,272,864
Ensembl chr 8:23,247,743...23,272,860
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Plcb1
phospholipase C, beta 1
increases expression
ISO
Zearalenone results in increased expression of PLCB1 mRNA
CTD
PMID:19371625 PMID:36828454
NCBI chr 2:134,628,084...135,317,178
Ensembl chr 2:134,627,987...135,317,178
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Plch1
phospholipase C, eta 1
increases expression
EXP
Zearalenone results in increased expression of PLCH1 protein
CTD
PMID:36252740
NCBI chr 3:63,603,620...63,806,929
Ensembl chr 3:63,603,655...63,806,893
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Plg
plasminogen
increases expression
ISO
Zearalenone results in increased expression of PLG mRNA
CTD
PMID:36828454
NCBI chr17:12,597,496...12,638,271
Ensembl chr17:12,597,495...12,638,272
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Plin1
perilipin 1
increases expression
EXP
Zearalenone results in increased expression of PLIN1 protein
CTD
PMID:25058043
NCBI chr 7:79,370,912...79,382,652
Ensembl chr 7:79,369,966...79,382,651
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Plppr2
phospholipid phosphatase related 2
increases expression
ISO
Zearalenone results in increased expression of PLPPR2 mRNA
CTD
PMID:19371625
NCBI chr 9:21,848,306...21,860,203
Ensembl chr 9:21,848,329...21,860,203
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Plxdc2
plexin domain containing 2
increases expression
ISO
Zearalenone results in increased expression of PLXDC2 mRNA
CTD
PMID:19371625
NCBI chr 2:16,360,551...16,765,941
Ensembl chr 2:16,361,115...16,760,650
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Pmm2
phosphomannomutase 2
decreases expression
EXP
Zearalenone results in decreased expression of PMM2 protein
CTD
PMID:36252740
NCBI chr16:8,455,467...8,475,472
Ensembl chr16:8,455,538...8,480,331
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Pnpla2
patatin-like phospholipase domain containing 2
increases expression multiple interactions
EXP
Zearalenone results in increased expression of PNPLA2 protein Nicotinamide Mononucleotide inhibits the reaction [Zearalenone results in increased expression of PNPLA2 protein]
CTD
PMID:38159578
NCBI chr 7:141,035,101...141,040,656
Ensembl chr 7:141,035,111...141,040,656
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Polr2c
polymerase (RNA) II (DNA directed) polypeptide C
increases expression
ISO
Zearalenone results in increased expression of POLR2C mRNA
CTD
PMID:19371625
NCBI chr 8:95,584,078...95,590,870
Ensembl chr 8:95,584,078...95,600,163
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Pou2f3
POU domain, class 2, transcription factor 3
decreases expression
ISO
Zearalenone results in decreased expression of POU2F3 mRNA
CTD
PMID:36828454
NCBI chr 9:43,035,222...43,117,052
Ensembl chr 9:43,035,234...43,121,666
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Ppa1
pyrophosphatase (inorganic) 1
decreases expression
EXP
Zearalenone results in decreased expression of PPA1 protein
CTD
PMID:36252740
NCBI chr10:61,484,400...61,509,944
Ensembl chr10:61,484,331...61,509,947
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Ppara
peroxisome proliferator activated receptor alpha
increases expression
ISO
Zearalenone results in increased expression of PPARA mRNA
CTD
PMID:32119988
NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020
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Ppard
peroxisome proliferator activator receptor delta
multiple interactions increases expression
EXP
Nicotinamide Mononucleotide inhibits the reaction [Zearalenone results in increased expression of PPARD mRNA]
CTD
PMID:38159578
NCBI chr17:28,451,715...28,520,446
Ensembl chr17:28,451,674...28,520,448
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Pparg
peroxisome proliferator activated receptor gamma
decreases activity increases expression decreases methylation multiple interactions
ISO EXP
Zearalenone results in decreased activity of PPARG protein Zearalenone results in increased expression of PPARG mRNA; Zearalenone results in increased expression of PPARG protein Zearalenone results in decreased methylation of PPARG promoter PPARG inhibits the reaction [Zearalenone results in increased expression of PGR mRNA]; PPARG inhibits the reaction [Zearalenone results in increased expression of TFF1 mRNA] Nicotinamide Mononucleotide inhibits the reaction [Zearalenone results in increased expression of PPARG mRNA]
CTD
PMID:27481073 PMID:32119988 PMID:35588983 PMID:38159578
NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360
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Ppargc1b
peroxisome proliferative activated receptor, gamma, coactivator 1 beta
increases expression
ISO
Zearalenone results in increased expression of PPARGC1B mRNA
CTD
PMID:36828454
NCBI chr18:61,424,516...61,533,846
Ensembl chr18:61,431,207...61,533,502
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Ppp1r1a
protein phosphatase 1, regulatory inhibitor subunit 1A
increases expression
ISO
Zearalenone results in increased expression of PPP1R1A mRNA
CTD
PMID:36828454
NCBI chr15:103,438,706...103,446,465
Ensembl chr15:103,438,706...103,446,430
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Prdm14
PR domain containing 14
increases expression
ISO
Zearalenone results in increased expression of PRDM14 mRNA
CTD
PMID:19371625
NCBI chr 1:13,183,649...13,197,467
Ensembl chr 1:13,183,681...13,197,387
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Prep
prolyl endopeptidase
decreases expression
EXP
Zearalenone results in decreased expression of PREP protein
CTD
PMID:25058043
NCBI chr10:44,943,312...45,038,847
Ensembl chr10:44,943,299...45,043,294
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Prh1
proline rich protein HaeIII subfamily 1
decreases expression
ISO
Zearalenone results in decreased expression of PRH1 mRNA
CTD
PMID:17557909
NCBI chr 6:132,546,805...132,549,364
Ensembl chr 6:132,546,772...132,549,904
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Prkaa2
protein kinase, AMP-activated, alpha 2 catalytic subunit
increases expression
EXP
Zearalenone results in increased expression of PRKAA2 mRNA
CTD
PMID:30717214
NCBI chr 4:104,886,846...104,967,095
Ensembl chr 4:104,887,071...104,967,087
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Prkar2a
protein kinase, cAMP dependent regulatory, type II alpha
increases expression
ISO
Zearalenone results in increased expression of PRKAR2A mRNA
CTD
PMID:19371625
NCBI chr 9:108,569,342...108,627,643
Ensembl chr 9:108,566,513...108,627,635
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Prmt6
protein arginine N-methyltransferase 6
increases expression
ISO
Zearalenone results in increased expression of PRMT6 mRNA
CTD
PMID:32119988
NCBI chr 3:110,153,420...110,158,315
Ensembl chr 3:110,153,425...110,158,314
G
Prps1l3
phosphoribosyl pyrophosphate synthetase 1-like 3
decreases expression
EXP
Zearalenone results in decreased expression of PRPS1L3 protein
CTD
PMID:36252740
NCBI chr12:57,277,198...57,288,954
Ensembl chr12:57,277,198...57,286,668
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Prps2
phosphoribosyl pyrophosphate synthetase 2
decreases expression
EXP
Zearalenone results in decreased expression of PRPS2 protein
CTD
PMID:36252740
NCBI chr X:166,129,316...166,165,887
Ensembl chr X:166,129,318...166,165,745
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Prss23
serine protease 23
increases expression
ISO
Zearalenone results in increased expression of PRSS23 mRNA
CTD
PMID:22494775
NCBI chr 7:89,156,988...89,176,399
Ensembl chr 7:89,156,991...89,176,395
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Prune1
prune exopolyphosphatase
decreases expression
EXP
Zearalenone results in decreased expression of PRUNE1 protein
CTD
PMID:36252740
NCBI chr 3:95,160,985...95,190,817
Ensembl chr 3:95,160,985...95,189,387
G
Psmc1
protease (prosome, macropain) 26S subunit, ATPase 1
decreases expression
EXP
Zearalenone results in decreased expression of PSMC1 protein
CTD
PMID:36252740
NCBI chr12:100,076,461...100,089,623
Ensembl chr12:100,076,413...100,089,664
G
Psmc2
proteasome (prosome, macropain) 26S subunit, ATPase 2
decreases expression
EXP
Zearalenone results in decreased expression of PSMC2 protein
CTD
PMID:36252740
NCBI chr 5:21,990,273...22,008,785
Ensembl chr 5:21,990,281...22,008,785
G
Psmc3
proteasome (prosome, macropain) 26S subunit, ATPase 3
decreases expression
EXP
Zearalenone results in decreased expression of PSMC3 protein
CTD
PMID:36252740
NCBI chr 2:90,884,361...90,889,783
Ensembl chr 2:90,884,354...90,896,714
G
Psmc4
proteasome (prosome, macropain) 26S subunit, ATPase, 4
decreases expression
EXP
Zearalenone results in decreased expression of PSMC4 protein
CTD
PMID:36252740
NCBI chr 7:27,741,127...27,749,517
Ensembl chr 7:27,741,132...27,749,526
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Psmd13
proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
decreases expression
EXP
Zearalenone results in decreased expression of PSMD13 protein
CTD
PMID:36252740
NCBI chr 7:140,462,307...140,478,555
Ensembl chr 7:140,461,881...140,478,556
G
Psmd2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
decreases expression
EXP
Zearalenone results in decreased expression of PSMD2 protein
CTD
PMID:36252740
NCBI chr16:20,469,872...20,482,164
Ensembl chr16:20,470,402...20,482,164
G
Psmg2
proteasome (prosome, macropain) assembly chaperone 2
decreases expression
EXP
Zearalenone results in decreased expression of PSMG2 protein
CTD
PMID:36252740
NCBI chr18:67,774,657...67,787,251
Ensembl chr18:67,774,669...67,787,232
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Pten
phosphatase and tensin homolog
increases expression decreases expression
EXP
Zearalenone results in increased expression of PTEN mRNA Zearalenone results in decreased expression of PTEN protein
CTD
PMID:27473017 PMID:30717214
NCBI chr19:32,734,977...32,803,560
Ensembl chr19:32,734,897...32,803,560
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Ptges3
prostaglandin E synthase 3
decreases expression
EXP
Zearalenone results in decreased expression of PTGES3 protein
CTD
PMID:36252740
NCBI chr10:127,894,851...127,913,123
Ensembl chr10:127,894,823...127,913,141
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Ptgr2
prostaglandin reductase 2
decreases expression
EXP
Zearalenone results in decreased expression of PTGR2 protein
CTD
PMID:36252740
NCBI chr12:84,332,011...84,362,606
Ensembl chr12:84,332,006...84,362,606
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Ptgs2
prostaglandin-endoperoxide synthase 2
increases expression
ISO
Zearalenone results in increased expression of PTGS2 mRNA
CTD
PMID:27757495 PMID:36828454
NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
G
Ptk2
PTK2 protein tyrosine kinase 2
decreases expression
EXP ISO
Zearalenone results in decreased expression of PTK2 protein
CTD
PMID:36288102
NCBI chr15:73,076,951...73,297,192
Ensembl chr15:73,076,951...73,295,129
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Pus7
pseudouridylate synthase 7
increases expression
ISO
Zearalenone results in increased expression of PUS7 mRNA
CTD
PMID:36828454
NCBI chr 5:23,945,163...23,988,709
Ensembl chr 5:23,945,646...23,988,709
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Pycard
PYD and CARD domain containing
multiple interactions increases expression
EXP ISO
[Dextran Sulfate co-treated with Zearalenone] results in increased expression of PYCARD mRNA; [Dextran Sulfate co-treated with Zearalenone] results in increased expression of PYCARD protein; Zearalenone inhibits the reaction [Dextran Sulfate results in increased expression of PYCARD mRNA]; Zearalenone inhibits the reaction [Dextran Sulfate results in increased expression of PYCARD protein] Zearalenone results in increased expression of PYCARD mRNA; Zearalenone results in increased expression of PYCARD protein [Zearalenone co-treated with Lipopolysaccharides] results in increased expression of PYCARD protein
CTD
PMID:30270565 PMID:31586597
NCBI chr 7:127,590,545...127,593,039
Ensembl chr 7:127,588,880...127,593,039
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Rab20
RAB20, member RAS oncogene family
decreases expression
ISO
Zearalenone results in decreased expression of RAB20 mRNA
CTD
PMID:19371625
NCBI chr 8:11,503,390...11,528,640
Ensembl chr 8:11,503,518...11,528,710
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Rack1
receptor for activated C kinase 1
increases expression
ISO
Zearalenone results in increased expression of RACK1 mRNA; Zearalenone results in increased expression of RACK1 protein
CTD
PMID:32328699
NCBI chr11:48,691,187...48,697,068
Ensembl chr11:48,691,159...48,697,261
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Rad51
RAD51 recombinase
decreases expression increases expression
EXP
Zearalenone results in decreased expression of RAD51 mRNA Zearalenone results in increased expression of RAD51 mRNA; Zearalenone results in increased expression of RAD51 protein
CTD
PMID:27862621 PMID:28552778 PMID:35650142
NCBI chr 2:118,943,295...118,966,554
Ensembl chr 2:118,943,274...118,977,926
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Raf1
v-raf-leukemia viral oncogene 1
increases expression
EXP
Zearalenone results in increased expression of RAF1 mRNA
CTD
PMID:29758222
NCBI chr 6:115,595,530...115,653,596
Ensembl chr 6:115,595,028...115,653,596
G
Ranbp1
RAN binding protein 1
decreases expression
EXP
Zearalenone results in decreased expression of RANBP1 protein
CTD
PMID:36252740
NCBI chr16:18,057,843...18,066,558
Ensembl chr16:18,057,648...18,066,596
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Rap1a
RAS-related protein 1a
decreases expression
EXP
Zearalenone results in decreased expression of RAP1A mRNA
CTD
PMID:30717214
NCBI chr 3:105,634,576...105,708,740
Ensembl chr 3:105,634,583...105,708,652
G
Rap1b
RAS related protein 1b
decreases expression
EXP
Zearalenone results in decreased expression of RAP1B mRNA
CTD
PMID:30717214
NCBI chr10:117,650,502...117,681,879
Ensembl chr10:117,649,776...117,681,940
G
Rapgef4
Rap guanine nucleotide exchange factor (GEF) 4
increases expression
ISO
Zearalenone results in increased expression of RAPGEF4 mRNA
CTD
PMID:36828454
NCBI chr 2:71,811,559...72,087,818
Ensembl chr 2:71,811,584...72,087,818
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Rarb
retinoic acid receptor, beta
decreases expression
ISO
Zearalenone results in decreased expression of RARB mRNA
CTD
PMID:28965971
NCBI chr14:5,387,365...6,038,924
Ensembl chr14:5,650,540...6,038,924
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Rars1
arginyl-tRNA synthetase 1
decreases expression
EXP
Zearalenone results in decreased expression of RARS1 protein
CTD
PMID:25058043
NCBI chr11:35,699,207...35,725,355
Ensembl chr11:35,699,208...35,725,333
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Rasgrp1
RAS guanyl releasing protein 1
increases expression
ISO
Zearalenone results in increased expression of RASGRP1 mRNA
CTD
PMID:36828454
NCBI chr 2:117,110,464...117,173,358
Ensembl chr 2:117,110,474...117,173,482
G
Rassf1
Ras association (RalGDS/AF-6) domain family member 1
increases expression
ISO
Zearalenone results in increased expression of RASSF1 mRNA
CTD
PMID:28965971
NCBI chr 9:107,428,752...107,439,460
Ensembl chr 9:107,428,754...107,439,466
G
Rassf2
Ras association (RalGDS/AF-6) domain family member 2
decreases expression
ISO
Zearalenone results in decreased expression of RASSF2 mRNA
CTD
PMID:36828454
NCBI chr 2:131,834,770...131,872,336
Ensembl chr 2:131,831,335...131,872,178
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Rbbp8
retinoblastoma binding protein 8, endonuclease
increases expression
ISO
Zearalenone results in increased expression of RBBP8 mRNA
CTD
PMID:36828454
NCBI chr18:11,766,333...11,876,264
Ensembl chr18:11,766,333...11,878,278
G
Rbbp8nl
RBBP8 N-terminal like
decreases expression
ISO
Zearalenone results in decreased expression of RBBP8NL mRNA
CTD
PMID:36828454
NCBI chr 2:179,917,039...179,931,693
Ensembl chr 2:179,919,439...179,931,672
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Rbm24
RNA binding motif protein 24
increases expression
ISO
Zearalenone results in increased expression of RBM24 mRNA
CTD
PMID:19371625
NCBI chr13:46,571,664...46,584,575
Ensembl chr13:46,571,910...46,584,571
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Rbp1
retinol binding protein 1, cellular
decreases expression
ISO
Zearalenone results in decreased expression of RBP1 mRNA
CTD
PMID:19371625
NCBI chr 9:98,305,014...98,328,604
Ensembl chr 9:98,305,014...98,328,628
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Rel
reticuloendotheliosis oncogene
decreases expression
EXP
Zearalenone results in decreased expression of REL protein
CTD
PMID:36252740
NCBI chr11:23,686,847...23,720,969
Ensembl chr11:23,686,847...23,720,970
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Rela
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
multiple interactions increases phosphorylation
ISO EXP
3-methyladenine promotes the reaction [Zearalenone results in increased phosphorylation of and affects the localization of RELA protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Zearalenone results in increased phosphorylation of and affects the localization of RELA protein]; Sirolimus inhibits the reaction [Zearalenone results in increased phosphorylation of and affects the localization of RELA protein]; Zearalenone results in increased phosphorylation of and affects the localization of RELA protein 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [corynoline inhibits the reaction [Zearalenone results in increased phosphorylation of RELA protein]]; corynoline inhibits the reaction [Zearalenone results in increased phosphorylation of RELA protein]
CTD
PMID:31586597 PMID:36161741
NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
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Rfk
riboflavin kinase
decreases expression
EXP
Zearalenone results in decreased expression of RFK protein
CTD
PMID:36252740
NCBI chr19:17,371,407...17,378,713
Ensembl chr19:17,371,407...17,378,713
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Rhobtb1
Rho-related BTB domain containing 1
increases expression
ISO
Zearalenone results in increased expression of RHOBTB1 mRNA
CTD
PMID:36828454
NCBI chr10:68,987,106...69,127,621
Ensembl chr10:68,987,264...69,127,621
G
Ribc2
RIB43A domain with coiled-coils 2
decreases expression
ISO
Zearalenone results in decreased expression of RIBC2 mRNA
CTD
PMID:19371625
NCBI chr15:85,016,261...85,028,771
Ensembl chr15:85,016,279...85,028,771
G
Rims4
regulating synaptic membrane exocytosis 4
increases expression
ISO
Zearalenone results in increased expression of RIMS4 mRNA
CTD
PMID:36828454
NCBI chr 2:163,701,676...163,760,893
Ensembl chr 2:163,701,671...163,760,603
G
Ripk1
receptor (TNFRSF)-interacting serine-threonine kinase 1
increases expression multiple interactions
EXP
Zearalenone results in increased expression of RIPK1 mRNA; Zearalenone results in increased expression of RIPK1 protein RIPK1 protein affects the reaction [Zearalenone results in increased cleavage of CASP3 protein]; scutellarin affects the reaction [RIPK1 protein affects the reaction [Zearalenone results in increased cleavage of CASP3 protein]]; scutellarin inhibits the reaction [Zearalenone results in increased expression of RIPK1 mRNA]; scutellarin inhibits the reaction [Zearalenone results in increased expression of RIPK1 protein]
CTD
PMID:36252740
NCBI chr13:34,181,072...34,219,153
Ensembl chr13:34,186,346...34,221,130
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Rmi2
RecQ mediated genome instability 2
decreases expression
ISO
Zearalenone results in decreased expression of RMI2 mRNA
CTD
PMID:19371625
NCBI chr16:10,652,923...10,661,099
Ensembl chr16:10,652,923...10,710,830
G
Rnf224
ring finger protein 224
decreases expression
ISO
Zearalenone results in decreased expression of RNF224 mRNA
CTD
PMID:36828454
NCBI chr 2:25,124,487...25,126,799
Ensembl chr 2:25,124,488...25,126,799
G
Rnh1
ribonuclease/angiogenin inhibitor 1
decreases expression
EXP
Zearalenone results in decreased expression of RNH1 protein
CTD
PMID:25058043 PMID:36252740
NCBI chr 7:140,740,239...140,752,764
Ensembl chr 7:140,740,239...140,752,770
G
Rpa3
replication protein A3
decreases expression
EXP
Zearalenone results in decreased expression of RPA3 protein
CTD
PMID:36252740
NCBI chr 6:8,255,936...8,259,141
Ensembl chr 6:8,255,936...8,259,173
G
Rpl14
ribosomal protein L14
decreases expression
EXP
Zearalenone results in decreased expression of RPL14 mRNA
CTD
PMID:30138655
NCBI chr 9:120,400,579...120,403,724
Ensembl chr 9:120,400,510...120,403,720
G
Rpl23a
ribosomal protein L23A
decreases expression
EXP
Zearalenone results in decreased expression of RPL23A mRNA
CTD
PMID:30138655
NCBI chr11:78,071,761...78,074,410
Ensembl chr11:78,071,758...78,074,410
G
Rps23
ribosomal protein S23
decreases expression
EXP
Zearalenone results in decreased expression of RPS23 protein
CTD
PMID:36252740
NCBI chr13:91,071,241...91,072,851
Ensembl chr13:91,071,077...91,073,069
G
Rps3
ribosomal protein S3
decreases expression
EXP
Zearalenone results in decreased expression of RPS3 protein
CTD
PMID:35504548
NCBI chr 7:99,127,103...99,132,916
Ensembl chr 7:99,127,103...99,132,945
G
Rps5
ribosomal protein S5
decreases expression
EXP
Zearalenone results in decreased expression of RPS5 mRNA
CTD
PMID:30138655
NCBI chr 7:12,656,223...12,660,613
Ensembl chr 7:12,656,217...12,660,613
G
Rps6
ribosomal protein S6
decreases expression
EXP
Zearalenone results in decreased expression of RPS6 protein
CTD
PMID:36252740
NCBI chr 4:86,772,336...86,775,604
Ensembl chr 4:86,772,897...86,775,649
G
Rps6kb1
ribosomal protein S6 kinase, polypeptide 1
multiple interactions decreases phosphorylation
EXP
2-aminoethyl diphenylborinate inhibits the reaction [Zearalenone results in decreased phosphorylation of RPS6KB1 protein]; acadesine promotes the reaction [Zearalenone results in decreased phosphorylation of RPS6KB1 protein]; Acetylcysteine inhibits the reaction [Zearalenone results in decreased phosphorylation of RPS6KB1 protein]; dorsomorphin inhibits the reaction [Zearalenone results in decreased phosphorylation of RPS6KB1 protein]; HERPUD1 protein inhibits the reaction [Zearalenone results in decreased phosphorylation of RPS6KB1 protein]
CTD
PMID:30394307 PMID:31982503
NCBI chr11:86,389,695...86,435,711
Ensembl chr11:86,389,697...86,435,631
G
Rps8
ribosomal protein S8
decreases expression
EXP
Zearalenone results in decreased expression of RPS8 mRNA
CTD
PMID:30138655
NCBI chr 4:117,011,033...117,013,329
Ensembl chr 4:117,011,024...117,013,440
G
Rragb
Ras-related GTP binding B
decreases expression
ISO
Zearalenone results in decreased expression of RRAGB mRNA
CTD
PMID:19371625
NCBI chr X:151,920,640...151,973,188
Ensembl chr X:151,922,977...151,954,939
G
Rrs1
ribosome biogenesis regulator 1
increases expression
ISO
Zearalenone results in increased expression of RRS1 mRNA
CTD
PMID:36828454
NCBI chr 1:9,615,633...9,617,680
Ensembl chr 1:9,615,633...9,617,680
G
Rubcnl
RUN and cysteine rich domain containing beclin 1 interacting protein like
increases expression
ISO
Zearalenone results in increased expression of RUBCNL mRNA
CTD
PMID:36828454
NCBI chr14:75,253,467...75,289,977
Ensembl chr14:75,253,467...75,289,972
G
S100a6
S100 calcium binding protein A6 (calcyclin)
decreases expression
EXP
Zearalenone results in decreased expression of S100A6 protein
CTD
PMID:36252740
NCBI chr 3:90,520,491...90,531,797
Ensembl chr 3:90,520,189...90,531,488
G
S100g
S100 calcium binding protein G
increases expression
ISO
Zearalenone results in increased expression of S100G mRNA
CTD
PMID:17557909
NCBI chr X:161,744,988...161,747,595
Ensembl chr X:161,744,988...161,747,595
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S1pr3
sphingosine-1-phosphate receptor 3
increases expression
ISO
Zearalenone results in increased expression of S1PR3 mRNA
CTD
PMID:19371625
NCBI chr13:51,562,654...51,576,833
Ensembl chr13:51,562,675...51,576,833
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Sae1
SUMO1 activating enzyme subunit 1
decreases expression
EXP
Zearalenone results in decreased expression of SAE1 protein
CTD
PMID:36252740
NCBI chr 7:16,054,161...16,121,821
Ensembl chr 7:16,054,159...16,121,731
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Samm50
SAMM50 sorting and assembly machinery component
increases expression
EXP
Zearalenone results in increased expression of SAMM50 protein
CTD
PMID:25058043
NCBI chr15:84,076,441...84,100,284
Ensembl chr15:84,076,442...84,101,468
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Sar1a
secretion associated Ras related GTPase 1A
decreases expression
EXP
Zearalenone results in decreased expression of SAR1A protein
CTD
PMID:36252740
NCBI chr10:61,516,096...61,529,076
Ensembl chr10:61,516,078...61,529,076
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Sat1
spermidine/spermine N1-acetyl transferase 1
decreases expression
ISO
Zearalenone results in decreased expression of SAT1 mRNA
CTD
PMID:19371625
NCBI chr X:153,996,128...153,999,345
Ensembl chr X:153,996,128...153,999,445
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Scd1
stearoyl-Coenzyme A desaturase 1
multiple interactions increases expression
EXP
Nicotinamide Mononucleotide inhibits the reaction [Zearalenone results in increased expression of SCD1 mRNA]
CTD
PMID:38159578
NCBI chr19:44,382,889...44,396,148
Ensembl chr19:44,382,894...44,396,318
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Sec31a
SEC31 homolog A, COPII coat complex component
decreases expression
EXP
Zearalenone results in decreased expression of SEC31A protein
CTD
PMID:36252740
NCBI chr 5:100,509,508...100,564,132
Ensembl chr 5:100,509,508...100,564,093
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Serbp1
serpine1 mRNA binding protein 1
decreases expression
EXP
Zearalenone results in decreased expression of SERBP1 protein
CTD
PMID:25058043
NCBI chr 6:67,243,963...67,266,286
Ensembl chr 6:67,215,160...67,274,720
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Serpine1
serine (or cysteine) peptidase inhibitor, clade E, member 1
multiple interactions
ISO
[Zearalenone co-treated with Aflatoxin B1] results in increased expression of SERPINE1 mRNA
CTD
PMID:28965971
NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122
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Sez6
seizure related gene 6
increases expression
ISO
Zearalenone results in increased expression of SEZ6 mRNA
CTD
PMID:36828454
NCBI chr11:77,821,403...77,869,874
Ensembl chr11:77,821,626...77,869,874
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Sf3b5
splicing factor 3b, subunit 5
increases expression
ISO
Zearalenone results in increased expression of SF3B5 mRNA
CTD
PMID:19371625
NCBI chr10:12,884,194...12,884,927
Ensembl chr10:12,881,087...12,884,927
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Sftpd
surfactant associated protein D
increases expression
ISO
Zearalenone results in increased expression of SFTPD mRNA
CTD
PMID:17557909
NCBI chr14:40,894,169...40,907,155
Ensembl chr14:40,894,171...40,907,106
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Siah1a
siah E3 ubiquitin protein ligase 1A
decreases expression
ISO
Zearalenone results in decreased expression of SIAH1 mRNA
CTD
PMID:19371625
NCBI chr 8:87,442,450...87,472,634
Ensembl chr 8:87,450,635...87,472,562
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Sirt1
sirtuin 1
decreases expression multiple interactions increases expression
EXP
Zearalenone results in decreased expression of SIRT1 protein 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [corynoline inhibits the reaction [Zearalenone results in decreased expression of SIRT1 protein]]; corynoline inhibits the reaction [Zearalenone results in decreased expression of SIRT1 protein]; Nicotinamide Mononucleotide inhibits the reaction [Zearalenone results in increased expression of SIRT1 mRNA]
CTD
PMID:36161741 PMID:38159578
NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483
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Slc12a8
solute carrier family 12 (potassium/chloride transporters), member 8
decreases expression multiple interactions
EXP
Zearalenone results in decreased expression of SLC12A8 mRNA Nicotinamide Mononucleotide inhibits the reaction [Zearalenone results in decreased expression of SLC12A8 mRNA]
CTD
PMID:38159578
NCBI chr16:33,337,440...33,484,508
Ensembl chr16:33,337,698...33,484,505
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Slc19a2
solute carrier family 19 (thiamine transporter), member 2
increases expression
ISO
Zearalenone results in increased expression of SLC19A2 mRNA
CTD
PMID:36828454
NCBI chr 1:164,076,615...164,092,954
Ensembl chr 1:164,076,615...164,092,954
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Slc1a5
solute carrier family 1 (neutral amino acid transporter), member 5
increases expression decreases expression
ISO
Zearalenone results in increased expression of SLC1A5 mRNA Zearalenone results in decreased expression of SLC1A5 mRNA; Zearalenone results in decreased expression of SLC1A5 protein
CTD
PMID:19371625 PMID:32858132
NCBI chr 7:16,515,259...16,532,199
Ensembl chr 7:16,515,265...16,532,199
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Slc22a3
solute carrier family 22 (organic cation transporter), member 3
increases expression
ISO
Zearalenone results in increased expression of SLC22A3 mRNA
CTD
PMID:36828454
NCBI chr17:12,638,859...12,726,591
Ensembl chr17:12,637,847...12,726,591
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Slc26a9
solute carrier family 26, member 9
decreases expression
ISO
Zearalenone results in decreased expression of SLC26A9 mRNA
CTD
PMID:36828454
NCBI chr 1:131,671,760...131,699,242
Ensembl chr 1:131,671,760...131,699,242
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Slc2a2
solute carrier family 2 (facilitated glucose transporter), member 2
increases expression
ISO
Zearalenone results in increased expression of SLC2A2 mRNA
CTD
PMID:32119988
NCBI chr 3:28,752,052...28,782,510
Ensembl chr 3:28,752,052...28,785,508
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Slc31a1
solute carrier family 31, member 1
increases expression
ISO
Zearalenone results in increased expression of SLC31A1 mRNA
CTD
PMID:19371625
NCBI chr 4:62,278,821...62,310,006
Ensembl chr 4:62,278,964...62,310,006
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Slc37a2
solute carrier family 37 (glycerol-3-phosphate transporter), member 2
increases expression
EXP
Zearalenone results in increased expression of SLC37A2 protein
CTD
PMID:36252740
NCBI chr 9:37,140,445...37,166,709
Ensembl chr 9:37,138,881...37,167,034
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Slc38a1
solute carrier family 38, member 1
decreases expression
ISO
Zearalenone results in decreased expression of SLC38A1 mRNA; Zearalenone results in decreased expression of SLC38A1 protein
CTD
PMID:32858132
NCBI chr15:96,469,299...96,541,396
Ensembl chr15:96,469,299...96,540,794
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Slc39a6
solute carrier family 39 (metal ion transporter), member 6
increases expression
ISO
Zearalenone results in increased expression of SLC39A6 mRNA
CTD
PMID:28965971
NCBI chr18:24,712,938...24,736,874
Ensembl chr18:24,712,938...24,736,874
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Slc3a2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
increases expression
ISO
Zearalenone results in increased expression of SLC3A2 mRNA
CTD
PMID:19371625
NCBI chr19:8,684,931...8,700,733
Ensembl chr19:8,684,246...8,700,733
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Slc41a3
solute carrier family 41, member 3
decreases expression
ISO
Zearalenone results in decreased expression of SLC41A3 mRNA
CTD
PMID:19371625
NCBI chr 6:90,579,043...90,623,394
Ensembl chr 6:90,581,707...90,623,394
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Slc6a15
solute carrier family 6 (neurotransmitter transporter), member 15
increases expression
ISO
Zearalenone results in increased expression of SLC6A15 mRNA
CTD
PMID:36828454
NCBI chr10:103,203,320...103,255,240
Ensembl chr10:103,203,644...103,255,238
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Slc6a6
solute carrier family 6 (neurotransmitter transporter, taurine), member 6
increases expression
ISO
Zearalenone results in increased expression of SLC6A6 mRNA
CTD
PMID:19371625
NCBI chr 6:91,661,031...91,736,044
Ensembl chr 6:91,661,034...91,736,047
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Slc7a11
solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
increases expression
ISO
Zearalenone results in increased expression of SLC7A11 mRNA
CTD
PMID:25424538
NCBI chr 3:50,319,385...50,403,947
Ensembl chr 3:49,846,975...50,398,063
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Slc7a2
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
increases expression
ISO
Zearalenone results in increased expression of SLC7A2 mRNA
CTD
PMID:36828454
NCBI chr 8:41,315,404...41,375,107
Ensembl chr 8:41,315,433...41,375,345
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Slc7a5
solute carrier family 7 (cationic amino acid transporter, y+ system), member 5
increases expression
ISO
Zearalenone results in increased expression of SLC7A5 mRNA
CTD
PMID:19371625 PMID:36828454
NCBI chr 8:122,607,885...122,634,425
Ensembl chr 8:122,607,889...122,634,433
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Slco1a5
solute carrier organic anion transporter family, member 1a5
decreases activity
ISO
Zearalenone results in decreased activity of SLCO1A2 protein
CTD
PMID:38341109
NCBI chr 6:142,179,953...142,268,707
Ensembl chr 6:142,179,953...142,268,707
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Slco1b2
solute carrier organic anion transporter family, member 1b2
decreases activity
ISO
Zearalenone results in decreased activity of SLCO1B3 protein
CTD
PMID:38341109
NCBI chr 6:141,575,178...141,632,372
Ensembl chr 6:141,575,244...141,632,372
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Slco2b1
solute carrier organic anion transporter family, member 2b1
decreases activity
ISO
Zearalenone results in decreased activity of SLCO2B1 protein
CTD
PMID:38341109
NCBI chr 7:99,307,011...99,360,547
Ensembl chr 7:99,307,011...99,360,547
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Slit2
slit guidance ligand 2
decreases expression
ISO
Zearalenone results in decreased expression of SLIT2 mRNA
CTD
PMID:28965971
NCBI chr 5:48,138,633...48,465,077
Ensembl chr 5:48,140,480...48,465,075
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Slitrk4
SLIT and NTRK-like family, member 4
increases expression
ISO
Zearalenone results in increased expression of SLITRK4 mRNA
CTD
PMID:36828454
NCBI chr X:63,308,489...63,320,951
Ensembl chr X:63,308,491...63,320,602
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Smad3
SMAD family member 3
multiple interactions increases expression
EXP
[Tamoxifen co-treated with Zearalenone] results in increased expression of SMAD3 mRNA Zearalenone results in increased expression of SMAD3 mRNA
CTD
PMID:30138655
NCBI chr 9:63,554,048...63,665,276
Ensembl chr 9:63,554,049...63,665,276
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Smpdl3b
sphingomyelin phosphodiesterase, acid-like 3B
multiple interactions
EXP
[Zearalenone co-treated with CGA protein] results in decreased expression of SMPDL3B protein
CTD
PMID:25058043
NCBI chr 4:132,460,277...132,484,558
Ensembl chr 4:132,460,277...132,484,563
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Snai2
snail family zinc finger 2
decreases expression
ISO
Zearalenone results in decreased expression of SNAI2 mRNA
CTD
PMID:28965971
NCBI chr16:14,523,716...14,527,259
Ensembl chr16:14,523,716...14,527,249
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Sod1
superoxide dismutase 1, soluble
decreases expression multiple interactions
ISO EXP
Zearalenone results in decreased expression of SOD1 mRNA; Zearalenone results in decreased expression of SOD1 protein Nicotinamide Mononucleotide inhibits the reaction [Zearalenone results in decreased expression of SOD1 protein]
CTD
PMID:32858132 PMID:38159578
NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217
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Sod2
superoxide dismutase 2, mitochondrial
decreases expression multiple interactions
ISO EXP
Zearalenone results in decreased expression of SOD2 mRNA; Zearalenone results in decreased expression of SOD2 protein [Nicotinamide Mononucleotide co-treated with Zearalenone] results in decreased expression of SOD2 mRNA
CTD
PMID:32858132 PMID:38159578
NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
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Sohlh2
spermatogenesis and oogenesis specific basic helix-loop-helix 2
decreases expression
EXP
Zearalenone results in decreased expression of SOHLH2 mRNA
CTD
PMID:28089945
NCBI chr 3:55,089,465...55,117,378
Ensembl chr 3:55,089,449...55,117,378
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Sox9
SRY (sex determining region Y)-box 9
decreases expression
EXP
Zearalenone results in decreased expression of SOX9 mRNA
CTD
PMID:24412631
NCBI chr11:112,673,036...112,678,583
Ensembl chr11:112,673,050...112,678,586
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Spata2
spermatogenesis associated 2
decreases expression
EXP
Zearalenone results in decreased expression of SPATA2 mRNA
CTD
PMID:24412631
NCBI chr 2:167,323,053...167,334,804
Ensembl chr 2:167,323,053...167,334,807
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Spsb3
splA/ryanodine receptor domain and SOCS box containing 3
decreases expression
ISO
Zearalenone results in decreased expression of SPSB3 mRNA
CTD
PMID:19371625
NCBI chr17:25,104,956...25,111,124
Ensembl chr17:25,105,617...25,111,126
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Sqle
squalene epoxidase
decreases expression
ISO
Zearalenone results in decreased expression of SQLE mRNA
CTD
PMID:19371625 PMID:25424538
NCBI chr15:59,186,941...59,203,042
Ensembl chr15:59,186,926...59,203,041
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Sqstm1
sequestosome 1
increases expression decreases expression
ISO EXP
Zearalenone results in increased expression of SQSTM1 protein Zearalenone results in decreased expression of SQSTM1 mRNA; Zearalenone results in decreased expression of SQSTM1 protein
CTD
PMID:31586597 PMID:31982503 PMID:32858132 PMID:34537261
NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654
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Srd5a1
steroid 5 alpha-reductase 1
decreases activity decreases expression
ISO
Zearalenone results in decreased activity of SRD5A1 protein Zearalenone results in decreased expression of SRD5A1 mRNA
CTD
PMID:29669061
NCBI chr13:69,721,568...69,759,611
Ensembl chr13:69,721,568...69,759,561
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Srebf1
sterol regulatory element binding transcription factor 1
increases expression
EXP
Zearalenone results in increased expression of SREBF1 mRNA
CTD
PMID:38159578
NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407
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Srxn1
sulfiredoxin 1 homolog (S. cerevisiae)
decreases expression multiple interactions
ISO
Zearalenone results in decreased expression of SRXN1 mRNA [Plant Extracts co-treated with Zearalenone] results in decreased expression of SRXN1 mRNA; [Zearalenone co-treated with ochratoxin A] results in decreased expression of SRXN1 mRNA
CTD
PMID:34015425
NCBI chr 2:151,946,738...151,953,296
Ensembl chr 2:151,947,436...151,953,296
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Ssc4d
scavenger receptor cysteine rich family, 4 domains
decreases expression
ISO
Zearalenone results in decreased expression of SSC4D mRNA
CTD
PMID:19371625
NCBI chr 5:135,989,074...136,003,389
Ensembl chr 5:135,989,065...136,003,385
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Ssu72
Ssu72 RNA polymerase II CTD phosphatase homolog (yeast)
decreases expression
EXP
Zearalenone results in decreased expression of SSU72 protein
CTD
PMID:36252740
NCBI chr 4:155,789,272...155,818,336
Ensembl chr 4:155,789,257...155,818,336
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St8sia1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
decreases expression
ISO
Zearalenone results in decreased expression of ST8SIA1 mRNA
CTD
PMID:36828454
NCBI chr 6:142,767,267...142,935,247
Ensembl chr 6:142,767,271...142,910,178
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Star
steroidogenic acute regulatory protein
multiple interactions increases expression decreases expression
EXP ISO
Colforsin affects the reaction [Zearalenone results in increased expression of STAR mRNA] Zearalenone results in decreased expression of STAR mRNA; Zearalenone results in decreased expression of STAR protein
CTD
PMID:24512812 PMID:26783879 PMID:29627501
NCBI chr 8:26,298,502...26,306,010
Ensembl chr 8:26,296,583...26,306,010
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Stat5a
signal transducer and activator of transcription 5A
decreases expression
EXP
Zearalenone results in decreased expression of STAT5A mRNA
CTD
PMID:30138655
NCBI chr11:100,750,177...100,775,995
Ensembl chr11:100,750,177...100,775,995
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Stk31
serine threonine kinase 31
decreases expression
EXP
Zearalenone results in decreased expression of STK31 protein
CTD
PMID:31419471
NCBI chr 6:49,372,441...49,446,440
Ensembl chr 6:49,372,538...49,446,435
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Stoml2
stomatin (Epb7.2)-like 2
increases expression
EXP
Zearalenone results in increased expression of STOML2 protein
CTD
PMID:25058043
NCBI chr 4:43,027,690...43,031,402
Ensembl chr 4:43,027,690...43,031,710
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Stra8
stimulated by retinoic acid gene 8
decreases expression
EXP
Zearalenone results in decreased expression of STRA8 mRNA
CTD
PMID:28552778
NCBI chr 6:34,897,098...34,916,279
Ensembl chr 6:34,897,098...34,916,279
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Strap
serine/threonine kinase receptor associated protein
decreases expression
EXP
Zearalenone results in decreased expression of STRAP protein
CTD
PMID:36252740
NCBI chr 6:137,712,080...137,728,928
Ensembl chr 6:137,712,076...137,728,930
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Sult1e1
sulfotransferase family 1E, member 1
decreases activity
ISO
Zearalenone results in decreased activity of SULT1E1 protein
CTD
PMID:16914110
NCBI chr 5:87,723,827...87,739,470
Ensembl chr 5:87,723,828...87,739,453
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Syap1
synapse associated protein 1
multiple interactions
EXP
[Zearalenone co-treated with CGA protein] results in decreased expression of SYAP1 protein
CTD
PMID:25058043
NCBI chr X:161,639,839...161,671,458
Ensembl chr X:161,640,053...161,671,443
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Sycp1
synaptonemal complex protein 1
increases expression
EXP
Zearalenone results in increased expression of SYCP1 mRNA
CTD
PMID:24412631
NCBI chr 3:102,725,815...102,843,416
Ensembl chr 3:102,725,815...102,843,416
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Sycp3
synaptonemal complex protein 3
decreases expression
EXP
Zearalenone results in decreased expression of SYCP3 mRNA; Zearalenone results in decreased expression of SYCP3 protein
CTD
PMID:24412631 PMID:28552778 PMID:31419471
NCBI chr10:88,295,449...88,309,098
Ensembl chr10:88,295,431...88,309,098
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Syncrip
synaptotagmin binding, cytoplasmic RNA interacting protein
decreases expression
EXP
Zearalenone results in decreased expression of SYNCRIP protein
CTD
PMID:36252740
NCBI chr 9:88,331,417...88,364,645
Ensembl chr 9:88,329,062...88,364,627
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Taldo1
transaldolase 1
decreases expression
EXP
Zearalenone results in decreased expression of TALDO1 protein
CTD
PMID:25058043
NCBI chr 7:140,972,073...140,982,889
Ensembl chr 7:140,972,112...140,982,881
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Tbcel
tubulin folding cofactor E-like
decreases expression
EXP
Zearalenone results in decreased expression of TBCEL protein
CTD
PMID:36252740
NCBI chr 9:42,323,612...42,383,534
Ensembl chr 9:42,323,612...42,419,105
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Tead3
TEA domain family member 3
increases expression
EXP
Zearalenone results in increased expression of TEAD3 mRNA
CTD
PMID:30138655
NCBI chr17:28,550,645...28,569,779
Ensembl chr17:28,550,645...28,569,791
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Tfap4
transcription factor AP4
increases expression
ISO
Zearalenone results in increased expression of TFAP4 mRNA
CTD
PMID:36828454
NCBI chr16:4,362,525...4,378,625
Ensembl chr16:4,362,525...4,377,718
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Tff1
trefoil factor 1
increases expression multiple interactions
ISO
Zearalenone results in increased expression of TFF1 mRNA deoxynivalenol promotes the reaction [Zearalenone results in increased expression of TFF1 mRNA]; PPARG inhibits the reaction [Zearalenone results in increased expression of TFF1 mRNA]
CTD
PMID:35588983
NCBI chr17:31,380,369...31,384,034
Ensembl chr17:31,380,369...31,384,251
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Tff3
trefoil factor 3, intestinal
increases expression
ISO
Zearalenone results in increased expression of TFF3 mRNA
CTD
PMID:28965971
NCBI chr17:31,344,280...31,348,585
Ensembl chr17:31,344,280...31,348,620
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Tgfa
transforming growth factor alpha
increases expression
ISO
Zearalenone results in increased expression of TGFA mRNA
CTD
PMID:19371625
NCBI chr 6:86,172,020...86,252,726
Ensembl chr 6:86,172,205...86,252,701
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Tgfb2
transforming growth factor, beta 2
decreases expression
EXP
Zearalenone results in decreased expression of TGFB2 mRNA
CTD
PMID:27862621 PMID:29758222
NCBI chr 1:186,354,984...186,441,504
Ensembl chr 1:186,354,989...186,438,186
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Tgm1
transglutaminase 1, K polypeptide
decreases expression
ISO
Zearalenone results in decreased expression of TGM1 mRNA
CTD
PMID:36828454
NCBI chr14:55,937,466...55,951,378
Ensembl chr14:55,937,466...55,951,383
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Th
tyrosine hydroxylase
decreases expression
ISO
Zearalenone results in decreased expression of TH mRNA
CTD
PMID:24412706
NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865
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Thbs1
thrombospondin 1
increases expression decreases expression
ISO
Zearalenone results in increased expression of THBS1 mRNA Zearalenone results in decreased expression of THBS1 mRNA
CTD
PMID:19371625 PMID:28965971
NCBI chr 2:117,942,357...117,957,614
Ensembl chr 2:117,942,357...117,957,614
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Thra
thyroid hormone receptor alpha
multiple interactions
ISO
Zearalenone binds to and results in increased activity of THRA protein
CTD
PMID:33049310
NCBI chr11:98,631,539...98,659,832
Ensembl chr11:98,631,464...98,659,832
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Thrb
thyroid hormone receptor beta
decreases activity multiple interactions
ISO
Zearalenone results in decreased activity of THRB protein [15-acetyldeoxynivalenol co-treated with 3-acetyldeoxynivalenol co-treated with deoxynivalenol co-treated with zearalenol co-treated with Zearalenone] results in decreased activity of THRB protein; Zearalenone inhibits the reaction [Triiodothyronine results in increased activity of THRB protein]
CTD
PMID:27481073 PMID:31077750
NCBI chr14:4,429,599...4,810,538
Ensembl chr14:4,431,611...4,809,435
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Timm17a
translocase of inner mitochondrial membrane 17a
increases expression
EXP
Zearalenone results in increased expression of TIMM17A protein
CTD
PMID:36252740
NCBI chr 1:135,229,273...135,241,475
Ensembl chr 1:135,222,951...135,241,516
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Tinf2
Terf1 (TRF1)-interacting nuclear factor 2
decreases expression
ISO
Zearalenone results in decreased expression of TINF2 mRNA
CTD
PMID:19371625
NCBI chr14:55,912,120...55,919,265
Ensembl chr14:55,912,146...55,919,277
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Tkt
transketolase
decreases expression
EXP
Zearalenone results in decreased expression of TKT protein
CTD
PMID:25058043
NCBI chr14:30,271,088...30,296,681
Ensembl chr14:30,270,316...30,296,677
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Tln1
talin 1
multiple interactions
EXP
[Zearalenone co-treated with CGA protein] results in increased expression of TLN1 protein
CTD
PMID:25058043
NCBI chr 4:43,531,513...43,562,583
Ensembl chr 4:43,531,519...43,562,691
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Tlr3
toll-like receptor 3
increases expression
ISO
Zearalenone results in increased expression of TLR3 mRNA
CTD
PMID:27757495
NCBI chr 8:45,848,702...45,864,112
Ensembl chr 8:45,848,702...45,864,117
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Tm6sf1
transmembrane 6 superfamily member 1
increases expression
ISO
Zearalenone results in increased expression of TM6SF1 mRNA
CTD
PMID:25424538
NCBI chr 7:81,507,810...81,533,827
Ensembl chr 7:81,508,749...81,534,182
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Tmem121
transmembrane protein 121
decreases expression
ISO
Zearalenone results in decreased expression of TMEM121 mRNA
CTD
PMID:19371625
NCBI chr12:113,149,523...113,153,143
Ensembl chr12:113,149,550...113,153,143
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Tmem215
transmembrane protein 215
increases expression
ISO
Zearalenone results in increased expression of TMEM215 mRNA
CTD
PMID:36828454
NCBI chr 4:40,472,180...40,475,653
Ensembl chr 4:40,472,180...40,477,168
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Tmem54
transmembrane protein 54
decreases expression
ISO
Zearalenone results in decreased expression of TMEM54 mRNA
CTD
PMID:19371625
NCBI chr 4:128,999,321...129,005,419
Ensembl chr 4:128,999,341...129,005,419
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Tnf
tumor necrosis factor
multiple interactions increases expression
EXP ISO
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [corynoline inhibits the reaction [Zearalenone results in increased expression of TNF protein]]; corynoline inhibits the reaction [Zearalenone results in increased expression of TNF protein]; Lipopolysaccharides promotes the reaction [Zearalenone results in increased expression of TNF mRNA]; Lycopene inhibits the reaction [Zearalenone results in increased expression of TNF]; Nicotinamide Mononucleotide inhibits the reaction [Zearalenone results in increased expression of TNF mRNA] Zearalenone results in increased expression of TNF; Zearalenone results in increased expression of TNF mRNA; Zearalenone results in increased expression of TNF protein 3-methyladenine promotes the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of TNF protein]; [Zearalenone co-treated with Lipopolysaccharides] results in increased expression of TNF mRNA; [Zearalenone co-treated with Lipopolysaccharides] results in increased expression of TNF protein; Gallic Acid inhibits the reaction [Zearalenone results in increased expression of TNF protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of TNF mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of TNF protein]; NLRP3 protein promotes the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of TNF protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of TNF mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Zearalenone results in increased expression of TNF protein]; Sirolimus inhibits the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of TNF protein] [Lipopolysaccharides co-treated with Zearalenone] results in increased secretion of TNF protein
CTD
PMID:16687389 PMID:25682699 PMID:31586597 PMID:32328699 PMID:34723416 PMID:36161741 PMID:38159578 More...
NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
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Tnfrsf25
tumor necrosis factor receptor superfamily, member 25
decreases expression
ISO
Zearalenone results in decreased expression of TNFRSF25 mRNA
CTD
PMID:19371625
NCBI chr 4:152,199,985...152,204,568
Ensembl chr 4:152,200,391...152,204,576
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Tnfsf10
tumor necrosis factor (ligand) superfamily, member 10
increases expression
ISO
Zearalenone results in increased expression of TNFSF10 mRNA
CTD
PMID:27757495
NCBI chr 3:27,371,226...27,393,814
Ensembl chr 3:27,371,177...27,396,576
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Tnnt1
troponin T1, skeletal, slow
decreases expression
ISO
Zearalenone results in decreased expression of TNNT1 mRNA
CTD
PMID:19371625
NCBI chr 7:4,507,568...4,518,974
Ensembl chr 7:4,507,569...4,519,381
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Tomm40
translocase of outer mitochondrial membrane 40
increases expression
EXP
Zearalenone results in increased expression of TOMM40 protein
CTD
PMID:25058043
NCBI chr 7:19,435,238...19,449,370
Ensembl chr 7:19,435,238...19,449,363
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Tomm70a
translocase of outer mitochondrial membrane 70A
increases expression
EXP
Zearalenone results in increased expression of TOMM70A protein
CTD
PMID:25058043
NCBI chr16:56,942,077...56,974,893
Ensembl chr16:56,942,066...56,977,068
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Tpi1
triosephosphate isomerase 1
decreases expression
EXP
Zearalenone results in decreased expression of TPI1 protein
CTD
PMID:36252740
NCBI chr 6:124,787,549...124,791,121
Ensembl chr 6:124,787,549...124,791,259
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Tpmt
thiopurine methyltransferase
decreases expression
EXP
Zearalenone results in decreased expression of TPMT protein
CTD
PMID:36252740
NCBI chr13:47,175,463...47,196,833
Ensembl chr13:47,175,958...47,198,213
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Tpt1
tumor protein, translationally-controlled 1
decreases expression
EXP
Zearalenone results in decreased expression of TPT1 protein
CTD
PMID:36252740
NCBI chr14:76,082,771...76,085,743
Ensembl chr14:76,082,533...76,085,965
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Trap1
TNF receptor-associated protein 1
increases expression
EXP
Zearalenone results in increased expression of TRAP1 protein
CTD
PMID:25058043
NCBI chr16:3,857,835...3,895,704
Ensembl chr16:3,857,835...3,895,691
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Trappc3l
trafficking protein particle complex 3 like
increases expression
ISO
Zearalenone results in increased expression of TRAPPC3L mRNA
CTD
PMID:36828454
NCBI chr10:33,913,593...33,985,811
Ensembl chr10:33,913,593...33,985,811
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Trf
transferrin
affects expression multiple interactions decreases expression
ISO
Zearalenone affects the expression of TF mRNA [deoxynivalenol co-treated with Zearalenone] affects the expression of TF mRNA; [deoxynivalenol co-treated with Zearalenone] results in increased expression of TF mRNA Zearalenone results in decreased expression of TF mRNA
CTD
PMID:28865950 PMID:28935499
NCBI chr 9:103,086,075...103,107,485
Ensembl chr 9:103,081,200...103,107,643
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Trp53
transformation related protein 53
decreases expression multiple interactions increases expression
EXP ISO
Zearalenone results in decreased expression of TRP53 mRNA; Zearalenone results in decreased expression of TRP53 protein [Zearalenone co-treated with Aflatoxin B1] promotes the reaction [deoxynivalenol results in increased expression of TP53 mRNA] Zearalenone results in increased expression of TP53 mRNA Zearalenone results in increased expression of TRP53 protein crocin inhibits the reaction [Zearalenone results in increased expression of TRP53 protein]
CTD
PMID:24412631 PMID:26231423 PMID:27473017 PMID:30668976
NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
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Trp73
transformation related protein 73
multiple interactions
ISO
[Zearalenone co-treated with Aflatoxin B1] results in increased expression of TP73 mRNA
CTD
PMID:28965971
NCBI chr 4:154,140,706...154,224,332
Ensembl chr 4:154,140,706...154,224,665
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Tsc22d1
TSC22 domain family, member 1
decreases expression
ISO
Zearalenone results in decreased expression of TSC22D1 mRNA
CTD
PMID:19371625
NCBI chr14:76,652,401...76,745,205
Ensembl chr14:76,652,401...76,745,205
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Tsen2
tRNA splicing endonuclease subunit 2
increases expression
ISO
Zearalenone results in increased expression of TSEN2 mRNA
CTD
PMID:36828454
NCBI chr 6:115,521,652...115,555,297
Ensembl chr 6:115,521,625...115,555,589
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Tshb
thyroid stimulating hormone, beta subunit
multiple interactions decreases expression
ISO
Gallic Acid inhibits the reaction [Zearalenone results in decreased expression of TSHB protein]
CTD
PMID:34723416
NCBI chr 3:102,684,621...102,718,175
Ensembl chr 3:102,682,781...102,690,034
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Tsku
tsukushi, small leucine rich proteoglycan
increases expression
ISO
Zearalenone results in increased expression of TSKU mRNA
CTD
PMID:19371625
NCBI chr 7:97,999,875...98,010,602
Ensembl chr 7:97,999,875...98,010,535
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Tspan1
tetraspanin 1
increases expression
ISO
Zearalenone results in increased expression of TSPAN1 mRNA
CTD
PMID:17557909
NCBI chr 4:116,019,078...116,024,818
Ensembl chr 4:116,019,066...116,024,798
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Tspan10
tetraspanin 10
decreases expression
ISO
Zearalenone results in decreased expression of TSPAN10 mRNA
CTD
PMID:19371625
NCBI chr11:120,333,457...120,338,147
Ensembl chr11:120,333,470...120,337,776
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Tspan12
tetraspanin 12
decreases expression
ISO
Zearalenone results in decreased expression of TSPAN12 mRNA
CTD
PMID:19371625
NCBI chr 6:21,771,390...21,879,557
Ensembl chr 6:21,771,394...21,852,514
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Tst
thiosulfate sulfurtransferase, mitochondrial
decreases expression
EXP
Zearalenone results in decreased expression of TST mRNA
CTD
PMID:30138655
NCBI chr15:78,283,756...78,290,065
Ensembl chr15:78,283,756...78,290,107
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Tuba1a
tubulin, alpha 1A
decreases expression
EXP
Zearalenone results in decreased expression of TUBA1A protein
CTD
PMID:36252740
NCBI chr15:98,847,728...98,851,382
Ensembl chr15:98,847,718...98,851,584
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Tubb4b
tubulin, beta 4B class IVB
decreases expression
EXP
Zearalenone results in decreased expression of TUBB4B protein
CTD
PMID:36252740
NCBI chr 2:25,112,170...25,114,714
Ensembl chr 2:25,112,172...25,114,714
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Tubb5
tubulin, beta 5 class I
decreases expression
EXP
Zearalenone results in decreased expression of TUBB5 protein
CTD
PMID:36252740
NCBI chr17:36,144,812...36,149,193
Ensembl chr17:36,144,813...36,149,198
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Twist1
twist basic helix-loop-helix transcription factor 1
decreases expression
ISO
Zearalenone results in decreased expression of TWIST1 mRNA
CTD
PMID:28965971
NCBI chr12:34,007,670...34,009,830
Ensembl chr12:34,007,670...34,009,828
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Txn1
thioredoxin 1
decreases expression
EXP
Zearalenone results in decreased expression of TXN1 protein
CTD
PMID:36252740
NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411
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Txnip
thioredoxin interacting protein
multiple interactions
ISO
[Plant Extracts co-treated with ochratoxin A co-treated with Zearalenone] results in increased expression of TXNIP mRNA; [Plant Extracts co-treated with Zearalenone] results in increased expression of TXNIP mRNA; [Zearalenone co-treated with ochratoxin A] results in increased expression of TXNIP mRNA
CTD
PMID:34015425
NCBI chr 3:96,465,273...96,469,173
Ensembl chr 3:96,465,273...96,469,199
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Uba1
ubiquitin-like modifier activating enzyme 1
decreases expression
EXP
Zearalenone results in decreased expression of UBA1 protein
CTD
PMID:36252740
NCBI chr X:20,524,660...20,549,420
Ensembl chr X:20,524,565...20,549,418
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Uba5
ubiquitin-like modifier activating enzyme 5
decreases expression
EXP
Zearalenone results in decreased expression of UBA5 protein
CTD
PMID:36252740
NCBI chr 9:103,923,786...103,940,767
Ensembl chr 9:103,923,798...103,940,333
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Uchl1
ubiquitin carboxy-terminal hydrolase L1
decreases expression
EXP
Zearalenone results in decreased expression of UCHL1 protein
CTD
PMID:36252740
NCBI chr 5:66,833,464...66,844,577
Ensembl chr 5:66,833,434...66,844,577
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Ucp2
uncoupling protein 2 (mitochondrial, proton carrier)
multiple interactions increases expression
ISO EXP
[Plant Extracts co-treated with ochratoxin A co-treated with Zearalenone co-treated with beauvericin] results in decreased expression of UCP2 mRNA; [Plant Extracts co-treated with ochratoxin A co-treated with Zearalenone] results in increased expression of UCP2 mRNA; [Plant Extracts co-treated with Zearalenone] results in increased expression of UCP2 mRNA Nicotinamide Mononucleotide inhibits the reaction [Zearalenone results in increased expression of UCP2 mRNA]
CTD
PMID:34015425 PMID:38159578
NCBI chr 7:100,142,565...100,148,832
Ensembl chr 7:100,142,544...100,151,227
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Ugt1a1
UDP glucuronosyltransferase 1 family, polypeptide A1
increases glucuronidation
ISO
UGT1A1 protein results in increased glucuronidation of Zearalenone
CTD
PMID:14557274
NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719
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Ugt1a10
UDP glycosyltransferase 1 family, polypeptide A10
increases glucuronidation
ISO
UGT1A10 protein results in increased glucuronidation of Zearalenone
CTD
PMID:14557274
NCBI chr 1:87,983,133...88,147,724
Ensembl chr 1:87,983,110...88,146,726
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Ugt1a9
UDP glucuronosyltransferase 1 family, polypeptide A9
increases glucuronidation
ISO
UGT1A9 protein results in increased glucuronidation of Zearalenone
CTD
PMID:14557274
NCBI chr 1:87,998,501...88,147,724
Ensembl chr 1:87,998,522...88,146,719
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Uqcrc2
ubiquinol cytochrome c reductase core protein 2
increases expression
EXP
Zearalenone results in increased expression of UQCRC2 protein
CTD
PMID:25058043
NCBI chr 7:120,234,412...120,258,746
Ensembl chr 7:120,234,399...120,258,747
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Usp5
ubiquitin specific peptidase 5 (isopeptidase T)
decreases expression
EXP
Zearalenone results in decreased expression of USP5 protein
CTD
PMID:36252740
NCBI chr 6:124,791,982...124,806,404
Ensembl chr 6:124,791,982...124,806,447
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Utp15
UTP15 small subunit processome component
increases expression
ISO
Zearalenone results in increased expression of UTP15 mRNA
CTD
PMID:19371625
NCBI chr13:98,383,353...98,399,500
Ensembl chr13:98,383,353...98,399,549
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Vat1
vesicle amine transport 1
increases expression
EXP
Zearalenone results in increased expression of VAT1 protein
CTD
PMID:25058043
NCBI chr11:101,349,574...101,357,025
Ensembl chr11:101,349,571...101,357,056
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Vcl
vinculin
decreases expression
ISO EXP
Zearalenone results in decreased expression of VCL protein
CTD
PMID:36288102
NCBI chr14:20,979,436...21,083,744
Ensembl chr14:20,979,466...21,083,744
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Vcpkmt
valosin containing protein lysine (K) methyltransferase
decreases expression
ISO
Zearalenone results in decreased expression of VCPKMT mRNA
CTD
PMID:19371625
NCBI chr12:69,623,504...69,629,883
Ensembl chr12:69,624,402...69,629,884
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Vdac1
voltage-dependent anion channel 1
increases expression
EXP
Zearalenone results in increased expression of VDAC1 protein
CTD
PMID:34716709
NCBI chr11:52,251,905...52,280,224
Ensembl chr11:52,251,687...52,280,224
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Vegfa
vascular endothelial growth factor A
decreases expression increases expression
EXP ISO
Zearalenone results in decreased expression of VEGFA mRNA Zearalenone results in increased expression of VEGFA mRNA
CTD
PMID:24412631 PMID:27757495
NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295
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Vldlr
very low density lipoprotein receptor
increases expression
ISO
Zearalenone results in increased expression of VLDLR mRNA
CTD
PMID:25424538
NCBI chr19:27,190,070...27,231,631
Ensembl chr19:27,193,884...27,231,631
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Vpreb1a
V-set pre-B cell surrogate light chain 1A
decreases expression
ISO
Zearalenone results in decreased expression of VPREB1 mRNA
CTD
PMID:25424538
NCBI chr16:16,686,265...16,687,119
Ensembl chr16:16,686,267...16,688,707
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Wee1
WEE 1 homolog 1 (S. pombe)
increases expression
EXP
Zearalenone results in increased expression of WEE1 protein
CTD
PMID:35504548
NCBI chr 7:109,721,266...109,742,506
Ensembl chr 7:109,721,253...109,742,493
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Wnt3
wingless-type MMTV integration site family, member 3
decreases expression
ISO
Zearalenone results in decreased expression of WNT3 protein
CTD
PMID:36288102
NCBI chr11:103,665,000...103,708,854
Ensembl chr11:103,664,976...103,708,783
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Wnt7a
wingless-type MMTV integration site family, member 7A
decreases expression
ISO
Zearalenone results in decreased expression of WNT7A mRNA
CTD
PMID:16534752
NCBI chr 6:91,340,963...91,388,335
Ensembl chr 6:91,340,963...91,388,345
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Wt1
WT1 transcription factor
decreases expression
EXP
Zearalenone results in decreased expression of WT1 mRNA
CTD
PMID:24412631
NCBI chr 2:104,956,874...105,003,959
Ensembl chr 2:104,956,874...105,003,961
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Wwp2
WW domain containing E3 ubiquitin protein ligase 2
decreases expression
ISO
Zearalenone results in decreased expression of WWP2 mRNA
CTD
PMID:19371625
NCBI chr 8:108,162,966...108,285,922
Ensembl chr 8:108,162,997...108,285,227
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Wwtr1
WW domain containing transcription regulator 1
increases expression
EXP
Zearalenone results in increased expression of WWTR1 mRNA; Zearalenone results in increased expression of WWTR1 protein
CTD
PMID:30138655
NCBI chr 3:57,363,065...57,483,331
Ensembl chr 3:57,363,070...57,483,331
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Xbp1
X-box binding protein 1
increases expression
ISO
Zearalenone results in increased expression of XBP1 mRNA
CTD
PMID:28965971
NCBI chr11:5,470,641...5,475,993
Ensembl chr11:5,470,659...5,475,893
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Xdh
xanthine dehydrogenase
increases activity multiple interactions
ISO
Zearalenone results in increased activity of XDH protein Gallic Acid inhibits the reaction [Zearalenone results in increased activity of XDH protein]
CTD
PMID:34723416
NCBI chr17:74,190,890...74,257,191
Ensembl chr17:74,190,890...74,257,191
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Yap1
yes-associated protein 1
increases expression increases phosphorylation
EXP
Zearalenone results in increased expression of YAP1 mRNA Zearalenone results in increased phosphorylation of YAP1 protein
CTD
PMID:30138655
NCBI chr 9:7,932,000...8,004,890
Ensembl chr 9:7,932,000...8,004,597
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Ykt6
YKT6 v-SNARE homolog (S. cerevisiae)
multiple interactions
EXP
[Zearalenone co-treated with CGA protein] results in increased expression of YKT6 protein
CTD
PMID:25058043
NCBI chr11:5,905,779...5,917,780
Ensembl chr11:5,905,693...5,917,780
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Zfp239
zinc finger protein 239
increases expression
ISO
Zearalenone results in increased expression of ZNF239 mRNA
CTD
PMID:36828454
NCBI chr 6:117,838,907...117,849,727
Ensembl chr 6:117,839,061...117,850,252
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Zkscan2
zinc finger with KRAB and SCAN domains 2
increases expression
ISO
Zearalenone results in increased expression of ZKSCAN2 mRNA
CTD
PMID:19371625
NCBI chr 7:123,074,607...123,105,685
Ensembl chr 7:123,074,607...123,099,672
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Zmym3
zinc finger, MYM-type 3
increases expression
ISO
Zearalenone results in increased expression of ZMYM3 mRNA
CTD
PMID:19371625
NCBI chr X:100,447,990...100,464,986
Ensembl chr X:100,447,990...100,464,455
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Zmynd10
zinc finger, MYND domain containing 10
decreases expression
ISO
Zearalenone results in decreased expression of ZMYND10 mRNA
CTD
PMID:19371625
NCBI chr 9:107,424,067...107,428,520
Ensembl chr 9:107,424,497...107,428,518
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