Nme1 (NME/NM23 nucleoside diphosphate kinase 1) - Rat Genome Database

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Gene: Nme1 (NME/NM23 nucleoside diphosphate kinase 1) Mus musculus
Analyze
Symbol: Nme1
Name: NME/NM23 nucleoside diphosphate kinase 1
RGD ID: 735394
MGI Page MGI
Description: Predicted to enable several functions, including DNA binding activity; nuclease activity; and purine ribonucleoside triphosphate binding activity. Acts upstream of or within lactation. Located in mitochondrion and myelin sheath. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in neuroblastoma; ovary epithelial cancer; and teratoma. Orthologous to human NME1 (NME/NM23 nucleoside diphosphate kinase 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AL024257; expressed in non-metastatic cells 1 protein; expressed in non-metastatic cells 1, protein; metastasis inhibition factor NM23; NDK A; NDP; NDP kinase A; NDPK-A; NM23-M; NM23-M1; NM23A; non-metastatic cells 1, protein (NM23A) expressed in; nucleoside diphosphate kinase A; nucleoside-diphosphate kinase 1; nucleotide diphosphate kinase; tumor metastatic process-associated protein
RGD Orthologs
Human
Rat
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391193,849,751 - 93,859,341 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1193,847,805 - 93,859,347 (-)EnsemblGRCm39 Ensembl
GRCm381193,958,925 - 93,968,272 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1193,956,979 - 93,968,521 (-)EnsemblGRCm38mm10GRCm38
MGSCv371193,820,239 - 93,829,835 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361194,718,303 - 94,727,903 (-)NCBIMGSCv36mm8
MGSCv361193,775,015 - 93,784,611 (-)NCBIMGSCv36mm8
Celera11103,573,962 - 103,581,369 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1158.89NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
(S)-naringenin  (ISO)
(Z)-3-butylidenephthalide  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2,4-trimethylbenzene  (ISO)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,6-dinitrotoluene  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
buspirone  (ISO)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calycosin  (ISO)
captan  (EXP)
carbon nanotube  (EXP,ISO)
chlorpyrifos  (EXP)
chromium(6+)  (EXP)
cisplatin  (ISO)
clobetasol  (EXP)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (EXP,ISO)
dibenzo[a,l]pyrene  (EXP,ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
dizocilpine maleate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
finasteride  (ISO)
flavonoids  (ISO)
flutamide  (ISO)
folic acid  (EXP)
folpet  (EXP)
FR900359  (ISO)
fulvestrant  (EXP,ISO)
gentamycin  (ISO)
glafenine  (ISO)
graphite  (ISO)
hyaluronic acid  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (EXP,ISO)
indometacin  (ISO)
inulin  (EXP)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
lipopolysaccharide  (ISO)
methidathion  (EXP)
methimazole  (ISO)
methylseleninic acid  (ISO)
myricetin  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
nickel atom  (ISO)
nimesulide  (ISO)
okadaic acid  (ISO)
ozone  (EXP)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
pyrimidifen  (ISO)
quercetin  (ISO)
resveratrol  (EXP)
rotenone  (ISO)
sarin  (ISO)
SB 431542  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sulfadimethoxine  (ISO)
sulforaphane  (ISO)
tamoxifen  (EXP)
Terfenadine  (ISO)
tetrachloroethene  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
triphenylstannane  (ISO)
trovafloxacin  (ISO)
tungsten  (EXP)
tunicamycin  (ISO)
undecane  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vorinostat  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Nm23-M2/NDP kinase B induces endogenous c-myc and nm23-M1/NDP kinase A overexpression in BAF3 cells. Both NDP kinases protect the cells from oxidative stress-induced death. Arnaud-Dabernat S, etal., Exp Cell Res. 2004 Dec 10;301(2):293-304.
2. NM23 gene expression in human prostatic carcinomas and benign prostatic hyperplasias: altered expression in combined androgen blockaded carcinomas. Borchers H, etal., J Urol. 1996 Jun;155(6):2080-4.
3. NM23 gene expression in human breast carcinomas: loss of correlation with cell proliferation in the advanced phase of tumor progression. Caligo MA, etal., Int J Cancer. 1997 Feb 20;74(1):102-11.
4. Nm23-H1 mutation in neuroblastoma. Chang CL, etal., Nature. 1994 Aug 4;370(6488):335-6.
5. Decreased expression of nucleoside diphosphate kinase alpha isoform, an nm23-H2 gene homolog, is associated with metastatic potential of rat mammary-adenocarcinoma cells. Fukuda M, etal., Int J Cancer. 1996 Feb 8;65(4):531-7.
6. De novo synthesis of pyrimidine nucleotides; emerging interfaces with signal transduction pathways. Huang M and Graves LM, Cell Mol Life Sci. 2003 Feb;60(2):321-36.
7. Analysis of nm23 gene expressions in human bladder and renal cancers. Kanayama H, etal., Int J Urol. 1994 Dec;1(4):324-31.
8. The human Nm23/nucleoside diphosphate kinases. Lacombe ML, etal., J Bioenerg Biomembr. 2000 Jun;32(3):247-58.
9. Increased expression of the NME1 gene is associated with metastasis in epithelial ovarian cancer. Leary JA, etal., Int J Cancer. 1995 Jun 22;64(3):189-95.
10. Plasma membrane-associated nucleoside diphosphate kinase (nm23) in the heart is regulated by beta-adrenergic signaling. Lutz S, etal., Br J Pharmacol. 2003 Nov;140(6):1019-26. Epub 2003 Oct 14.
11. Nm23 expression in endometrial and cervical cancer: inverse correlation with lymph node involvement and myometrial invasion. Marone M, etal., Br J Cancer. 1996 Oct;74(7):1063-8.
12. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
13. MGDs mouse GO annotations MGD data from the GO Consortium
14. Allelic loss and somatic differentiation in human male germ cell tumors. Murty VV, etal., Oncogene. 1994 Aug;9(8):2245-51.
15. Prognostic value of nm23 protein expression in renal cell carcinomas. Nakagawa Y, etal., Oncology. 1998 Jul-Aug;55(4):370-6.
16. Large-scale screen for genes controlling mammalian embryogenesis, using high-throughput gene expression analysis in mouse embryos. Neidhardt L, etal., Mech Dev 2000 Nov;98(1-2):77-94.
17. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. Immunohistochemical analysis of nucleoside diphosphate kinases in oral squamous cell carcinomas. Otsuki K, etal., Oncology. 1997 Jan-Feb;54(1):63-8.
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
22. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
23. Mouse MP Annotation Import Pipeline RGD automated import pipeline
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. nm23 in ovarian cancer: correlation with clinical outcome and other clinicopathologic and biochemical prognostic parameters. Scambia G, etal., J Clin Oncol. 1996 Feb;14(2):334-42.
26. Proteome analysis of human pancreatic ductal adenocarcinoma tissue using two-dimensional gel electrophoresis and tandem mass spectrometry for identification of disease-related proteins. Tian R, etal., Dig Dis Sci. 2008 Jan;53(1):65-72. Epub 2007 May 11.
27. Reduced expression of nm23-H1, but not of nm23-H2, is concordant with the frequency of lymph-node metastasis of human breast cancer. Tokunaga Y, etal., Int J Cancer. 1993 Aug 19;55(1):66-71.
28. Potential prognostic value in human breast cancer of cytosolic Nme1 protein detection using an original hen specific antibody. Toulas C, etal., Br J Cancer. 1996 Mar;73(5):630-5.
29. Expression of nm23-H1 and nm23-H2 protein in endometrial carcinoma. Watanabe J, etal., Br J Cancer. 1995 Dec;72(6):1469-73.
Additional References at PubMed
PMID:1320361   PMID:1337998   PMID:1377015   PMID:2013093   PMID:2509941   PMID:3346912   PMID:7671812   PMID:8453711   PMID:8543593   PMID:8600152   PMID:9488696   PMID:9507200  
PMID:9878823   PMID:9881672   PMID:10349636   PMID:10452942   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12383506   PMID:12477932   PMID:12520002   PMID:12848338  
PMID:12904583   PMID:14561754   PMID:14610273   PMID:14681479   PMID:15485929   PMID:15489334   PMID:15511071   PMID:15782199   PMID:15928304   PMID:16082520   PMID:16141072   PMID:16141073  
PMID:16466905   PMID:17033939   PMID:17634366   PMID:17671192   PMID:17967808   PMID:18495661   PMID:18614015   PMID:18799693   PMID:18815136   PMID:19235734   PMID:19805292   PMID:19837676  
PMID:19885951   PMID:20841469   PMID:20944141   PMID:21490937   PMID:21541759   PMID:21873635   PMID:22006949   PMID:22080566   PMID:22699362   PMID:23023023   PMID:23665500   PMID:24970086  
PMID:24994937   PMID:25253077   PMID:26299592   PMID:26590968   PMID:26816005   PMID:28077425   PMID:28378742   PMID:30333137   PMID:30411342   PMID:30458180   PMID:30550785   PMID:30713523  
PMID:32325033   PMID:32675240   PMID:32853992   PMID:32860079   PMID:33024267   PMID:34433909   PMID:34709266   PMID:36116139   PMID:36293380   PMID:36417873   PMID:37624843  


Genomics

Comparative Map Data
Nme1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391193,849,751 - 93,859,341 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1193,847,805 - 93,859,347 (-)EnsemblGRCm39 Ensembl
GRCm381193,958,925 - 93,968,272 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1193,956,979 - 93,968,521 (-)EnsemblGRCm38mm10GRCm38
MGSCv371193,820,239 - 93,829,835 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361194,718,303 - 94,727,903 (-)NCBIMGSCv36mm8
MGSCv361193,775,015 - 93,784,611 (-)NCBIMGSCv36mm8
Celera11103,573,962 - 103,581,369 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1158.89NCBI
NME1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381751,153,559 - 51,162,168 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1751,153,559 - 51,162,428 (+)EnsemblGRCh38hg38GRCh38
GRCh371749,230,920 - 49,239,529 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361746,585,919 - 46,594,449 (+)NCBINCBI36Build 36hg18NCBI36
Build 341746,585,918 - 46,594,449NCBI
Celera1745,692,176 - 45,700,706 (+)NCBICelera
Cytogenetic Map17q21.33NCBI
HuRef1744,600,187 - 44,608,715 (+)NCBIHuRef
CHM1_11749,295,556 - 49,304,086 (+)NCBICHM1_1
T2T-CHM13v2.01752,020,874 - 52,029,483 (+)NCBIT2T-CHM13v2.0
Nme1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81079,403,939 - 79,426,620 (-)NCBIGRCr8
mRatBN7.21078,907,036 - 78,929,659 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1078,906,083 - 78,916,408 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1083,517,884 - 83,527,291 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01083,015,983 - 83,025,392 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01078,487,338 - 78,496,721 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01081,657,152 - 81,666,542 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1081,657,153 - 81,666,523 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01081,487,114 - 81,496,485 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41082,591,705 - 82,601,075 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11082,606,074 - 82,615,445 (-)NCBI
Celera1077,703,467 - 77,712,916 (-)NCBICelera
Cytogenetic Map10q26NCBI
NME1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21967,341,196 - 67,349,732 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11772,148,244 - 72,156,797 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01745,243,588 - 45,252,135 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11750,113,321 - 50,121,602 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1750,113,622 - 50,131,636 (+)Ensemblpanpan1.1panPan2
NME1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1926,990,336 - 26,998,895 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl926,990,469 - 26,998,955 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha926,321,054 - 26,326,903 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0927,784,176 - 27,792,716 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl927,784,309 - 27,792,772 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1926,552,843 - 26,558,695 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0926,812,400 - 26,818,250 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0926,942,481 - 26,948,330 (+)NCBIUU_Cfam_GSD_1.0
NME1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1227,416,346 - 27,436,140 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11227,416,308 - 27,435,044 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21227,484,195 - 27,502,922 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103242912
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11642,186,039 - 42,195,608 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1642,185,260 - 42,195,616 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607712,895,727 - 12,905,352 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Nme1
335 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:985
Count of miRNA genes:608
Interacting mature miRNAs:711
Transcripts:ENSMUST00000021220, ENSMUST00000107844, ENSMUST00000135884
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116215600596156153Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116331940794063918Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116483033698830473Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116483033698830473Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116483033698830473Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170691198104691366Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170691198104691366Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170691198104691366Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
1302124Eae7_msusceptibility to experimental allergic encephalomyelitis 7 (mouse)Not determined117757387399377820Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179156009107616472Mouse
14746970Manh71_mmandible shape 71 (mouse)1179416257113416257Mouse
10043865T2dm5sa_mtype 2 diabetes mellitus 5 in SMXA RI mice (mouse)Not determined1179813759104502698Mouse
27226758Femd3_mfemur midshaft diameter 3, 5 week (mouse)1180890826101890826Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181574481115574636Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181810267115810267Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182377698116377820Mouse
15092049Wsigrme3_mweek six growth rate, maternal effect 3 (mouse)118487732496629512Mouse
15092057Lgrme3_mlate growth rate, maternal effect 3 (mouse)118487732496629512Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185844911119844911Mouse
15039374Adip29_madiposity 29 (mouse)1186608320120608320Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186608320120608320Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186608320120608320Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187490826121873369Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187502600121502698Mouse
1357631Motr1_mmodifier of tubby retinal degeneration 1 (mouse)Not determined1187691198103274115Mouse
1301491Abbp4_mA/J and C57BL/6 blood pressure 4 (mouse)Not determined118869958899081597Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189869251121973369Mouse
13524529Bodwtq10_mbody wweight QTL 10 (mouse)119067951297699512Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191604608121973369Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191604608121973369Mouse
10045617Heal26_mwound healing/regeneration 26 (mouse)Not determined1192939373112544554Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193229183121973369Mouse

Markers in Region
RH125515  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381193,959,381 - 93,959,498UniSTSGRCm38
MGSCv371193,820,695 - 93,820,812UniSTSGRCm37
Celera11103,574,418 - 103,574,535UniSTS
Cytogenetic Map11DUniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000021220   ⟹   ENSMUSP00000021220
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1193,850,298 - 93,856,869 (-)Ensembl
GRCm38.p6 Ensembl1193,959,472 - 93,966,043 (-)Ensembl
RefSeq Acc Id: ENSMUST00000107844   ⟹   ENSMUSP00000103475
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1193,851,494 - 93,859,098 (-)Ensembl
GRCm38.p6 Ensembl1193,960,668 - 93,968,272 (-)Ensembl
RefSeq Acc Id: ENSMUST00000135884   ⟹   ENSMUSP00000117022
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1193,847,805 - 93,859,347 (-)Ensembl
GRCm38.p6 Ensembl1193,956,979 - 93,968,521 (-)Ensembl
RefSeq Acc Id: NM_001378854   ⟹   NP_001365783
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391193,849,751 - 93,858,851 (-)NCBI
GRCm381193,958,925 - 93,968,025 (-)NCBI
Sequence:
RefSeq Acc Id: NM_008704   ⟹   NP_032730
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391193,849,751 - 93,859,098 (-)NCBI
GRCm381193,958,925 - 93,968,272 (-)NCBI
MGSCv371193,820,239 - 93,829,835 (-)RGD
Celera11103,573,962 - 103,581,369 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036156410   ⟹   XP_036012303
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391193,849,751 - 93,858,882 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036156411   ⟹   XP_036012304
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391193,849,751 - 93,859,341 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_032730   ⟸   NM_008704
- UniProtKB: P15532 (UniProtKB/Swiss-Prot),   Q5NC81 (UniProtKB/TrEMBL),   Q5NC80 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001365783   ⟸   NM_001378854
- UniProtKB: P15532 (UniProtKB/Swiss-Prot),   Q5NC81 (UniProtKB/TrEMBL),   Q5NC80 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000103475   ⟸   ENSMUST00000107844
RefSeq Acc Id: ENSMUSP00000117022   ⟸   ENSMUST00000135884
RefSeq Acc Id: ENSMUSP00000021220   ⟸   ENSMUST00000021220
RefSeq Acc Id: XP_036012304   ⟸   XM_036156411
- Peptide Label: isoform X2
- UniProtKB: Q5NC79 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036012303   ⟸   XM_036156410
- Peptide Label: isoform X1
Protein Domains
Nucleoside diphosphate kinase-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P15532-F1-model_v2 AlphaFold P15532 1-152 view protein structure

Promoters
RGD ID:6821439
Promoter ID:MM_KWN:9227
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000107844,   OTTMUST00000002951
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361193,829,279 - 93,829,779 (-)MPROMDB
RGD ID:8676186
Promoter ID:EPDNEW_M16123
Type:initiation region
Name:Nme1_1
Description:Mus musculus NME/NM23 nucleoside diphosphate kinase 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381193,968,272 - 93,968,332EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97355 AgrOrtholog
Ensembl Genes ENSMUSG00000037601 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000021220.10 UniProtKB/TrEMBL
  ENSMUST00000107844 ENTREZGENE
  ENSMUST00000107844.3 UniProtKB/TrEMBL
  ENSMUST00000135884 ENTREZGENE
  ENSMUST00000135884.8 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.70.141 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro NDK-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NDK-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleoside_diP_kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleoside_diP_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18102 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:97355 ENTREZGENE
NCBI Gene 18102 ENTREZGENE
PANTHER NUCLEOSIDE DIPHOSPHATE KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEOSIDE DIPHOSPHATE KINASE A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam NDK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nme1 PhenoGen
PRINTS NUCDPKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NDP_KINASES UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NDPK_LIKE UniProtKB/Swiss-Prot
SMART NDK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54919 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt NDKA_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q5NC79 ENTREZGENE, UniProtKB/TrEMBL
  Q5NC80 ENTREZGENE, UniProtKB/TrEMBL
  Q5NC81 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-06-05 Nme1  NME/NM23 nucleoside diphosphate kinase 1  Nme1  non-metastatic cells 1, protein (NM23A) expressed in  Symbol and/or name change 5135510 APPROVED