Kbtbd8 (kelch repeat and BTB (POZ) domain containing 8) - Rat Genome Database
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Gene: Kbtbd8 (kelch repeat and BTB (POZ) domain containing 8) Mus musculus
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Symbol: Kbtbd8
Name: kelch repeat and BTB (POZ) domain containing 8
RGD ID: 1557457
MGI Page MGI
Description: Is expressed in forelimb bud and genitourinary system. Orthologous to human KBTBD8 (kelch repeat and BTB domain containing 8); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene; genistein.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AU040152; kelch repeat and BTB domain-containing protein 8; MGC91215; mKIAA1842; SSEC; SSEC 51; SSEC-; SSEC-51; SSEC51; T-cell activation kelch repeat protein; Ta; Takrp
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39695,094,861 - 95,106,774 (+)NCBIGRCm39mm39
GRCm39 Ensembl695,094,221 - 95,106,771 (+)Ensembl
GRCm38695,117,880 - 95,129,793 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl695,117,240 - 95,129,790 (+)EnsemblGRCm38mm10GRCm38
MGSCv37695,067,900 - 95,079,784 (+)NCBIGRCm37mm9NCBIm37
MGSCv36695,083,984 - 95,095,182 (+)NCBImm8
Celera697,004,030 - 97,015,920 (+)NCBICelera
Cytogenetic Map6D2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:10349636   PMID:10934024   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11544199   PMID:12466851   PMID:12477932   PMID:15489334   PMID:16141072   PMID:16141073   PMID:17015433  
PMID:18287559   PMID:18799693   PMID:18973680   PMID:21677750   PMID:21873635   PMID:26238476   PMID:32325033  


Genomics

Comparative Map Data
Kbtbd8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39695,094,861 - 95,106,774 (+)NCBIGRCm39mm39
GRCm39 Ensembl695,094,221 - 95,106,771 (+)Ensembl
GRCm38695,117,880 - 95,129,793 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl695,117,240 - 95,129,790 (+)EnsemblGRCm38mm10GRCm38
MGSCv37695,067,900 - 95,079,784 (+)NCBIGRCm37mm9NCBIm37
MGSCv36695,083,984 - 95,095,182 (+)NCBImm8
Celera697,004,030 - 97,015,920 (+)NCBICelera
Cytogenetic Map6D2NCBI
KBTBD8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl366,998,307 - 67,011,210 (+)EnsemblGRCh38hg38GRCh38
GRCh38366,998,307 - 67,011,210 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37367,048,731 - 67,061,634 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36367,132,093 - 67,144,324 (+)NCBINCBI36hg18NCBI36
Celera366,994,219 - 67,007,126 (+)NCBI
Cytogenetic Map3p14.1NCBI
HuRef367,065,693 - 67,078,598 (+)NCBIHuRef
CHM1_1366,999,762 - 67,012,669 (+)NCBICHM1_1
Kbtbd8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24127,675,967 - 127,688,785 (+)NCBI
Rnor_6.0 Ensembl4127,164,453 - 127,177,477 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04127,164,728 - 127,177,537 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04191,675,736 - 191,688,535 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44129,486,938 - 129,498,495 (+)NCBIRGSC3.4rn4RGSC3.4
Celera4116,576,838 - 116,587,813 (+)NCBICelera
Cytogenetic Map4q34NCBI
Kbtbd8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542120,688,674 - 20,698,436 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542120,685,884 - 20,698,409 (-)NCBIChiLan1.0ChiLan1.0
KBTBD8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1368,272,169 - 68,285,068 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl368,272,169 - 68,285,068 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0366,903,965 - 66,916,924 (+)NCBIMhudiblu_PPA_v0panPan3
KBTBD8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2024,480,578 - 24,489,827 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12024,477,732 - 24,489,594 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Kbtbd8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493660344,960 - 60,494 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KBTBD8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1348,486,978 - 48,501,345 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11348,486,919 - 48,499,992 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21353,316,639 - 53,322,573 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KBTBD8
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12228,018,662 - 28,031,863 (+)NCBI
ChlSab1.1 Ensembl2228,019,220 - 28,031,855 (+)Ensembl
Kbtbd8
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247731,376,745 - 1,390,396 (+)NCBI

Position Markers
AU040152  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381175,885,867 - 75,885,998UniSTSGRCm38
GRCm38695,129,466 - 95,129,597UniSTSGRCm38
MGSCv371175,699,369 - 75,699,500UniSTSGRCm37
MGSCv37695,079,460 - 95,079,591UniSTSGRCm37
Celera1183,395,210 - 83,395,341UniSTS
Celera697,015,596 - 97,015,727UniSTS
Cytogenetic Map11B4UniSTS
Cytogenetic Map6D2UniSTS
Whitehead/MRC_RH6979.38UniSTS
UniSTS:235507  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38695,129,087 - 95,129,485UniSTSGRCm38
MGSCv37695,079,081 - 95,079,479UniSTSGRCm37
Celera697,015,217 - 97,015,615UniSTS
Cytogenetic Map6D2UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396656149Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396656149Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396656149Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396656149Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652161713116155267Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66348473897484905Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666713869100714031Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670425898104426034Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670425898104426034Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670425898104426034Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671575060105575178Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671981024105981170Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671981024105981170Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673500000134700000Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675447583104503555Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675607306109607450Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675716503109716697Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676463949110464093Mouse
13824985Alh1_mamplitude of lateral head displacement 1 (mouse)67800000097000000Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678629504121115387Mouse
14696731Pairq1_mP. aeruginosa infection resistance QTL 1 (mouse)681500000102200000Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683713869147052561Mouse
11251720Ewc4_methanol withdrawal and consumption 4 (mouse)684122513118122513Mouse
1301687Mnic2_mmacronutrient intake (mouse)Not determined686806805113544602Mouse
1301744Hdlq11_mHDL QTL 11 (mouse)Not determined687503360121503555Mouse
1301262Gasa3_mgastritis type A susceptibility locus 3 (mouse)Not determined689005405123005603Mouse
1301244Ichs_mimmediate cutaneous hypersensitivity QTL (mouse)Not determined690795610124795846Mouse
11532719Sluc45_msusceptibility to lung cancer 45 (mouse)69260730698258933Mouse
4141578Obrq1_mobesity resistance QTL 1 (mouse)Not determined92607306112004738Mouse
11353842Bmiq4_mbody mass index QTL 4 (mouse)692607306146429238Mouse
1301292Cfbw2_mcystic fibrosis body weight 2 (mouse)Not determined695004651129004738Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1448
Count of miRNA genes:493
Interacting mature miRNAs:583
Transcripts:ENSMUST00000032107, ENSMUST00000119582, ENSMUST00000122938, ENSMUST00000145387
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000032107   ⟹   ENSMUSP00000032107
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl695,117,740 - 95,129,790 (+)Ensembl
RefSeq Acc Id: ENSMUST00000119582   ⟹   ENSMUSP00000113739
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl695,117,880 - 95,129,790 (+)Ensembl
RefSeq Acc Id: ENSMUST00000122938   ⟹   ENSMUSP00000145009
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl695,117,240 - 95,121,890 (+)Ensembl
RefSeq Acc Id: ENSMUST00000145387
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl695,117,984 - 95,121,797 (+)Ensembl
RefSeq Acc Id: NM_001008785   ⟹   NP_001008785
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39695,094,861 - 95,106,774 (+)NCBI
GRCm38695,117,880 - 95,129,793 (+)NCBI
MGSCv37695,067,900 - 95,079,784 (+)RGD
Celera697,004,004 - 97,015,923 (+)NCBI
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001102670   ⟹   NP_001096140
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39695,094,861 - 95,106,774 (+)NCBI
GRCm38695,117,880 - 95,129,793 (+)NCBI
MGSCv37695,067,900 - 95,079,784 (+)RGD
Celera697,004,004 - 97,015,923 (+)NCBI
cM Map6 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001008785   ⟸   NM_001008785
- Peptide Label: isoform a
- UniProtKB: Q3UQV5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001096140   ⟸   NM_001102670
- Peptide Label: isoform b
- UniProtKB: Q3UQV5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000113739   ⟸   ENSMUST00000119582
RefSeq Acc Id: ENSMUSP00000032107   ⟸   ENSMUST00000032107
RefSeq Acc Id: ENSMUSP00000145009   ⟸   ENSMUST00000122938
Protein Domains
BACK   BTB

Promoters
RGD ID:6839524
Promoter ID:MM_KWN:46983
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Spleen
Transcripts:ENSMUST00000119582,   OTTMUST00000073683,   OTTMUST00000073685,   OTTMUST00000073686
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36695,067,676 - 95,068,176 (+)MPROMDB
RGD ID:6890498
Promoter ID:EPDNEW_M8700
Type:initiation region
Name:Kbtbd8_1
Description:Mus musculus kelch repeat and BTB domain containing 8 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38695,117,919 - 95,117,979EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2661430 AgrOrtholog
Ensembl Genes ENSMUSG00000030031 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000032107 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000113739 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000145009 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000032107 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000119582 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000122938 UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.80 UniProtKB/Swiss-Prot
InterPro BACK UniProtKB/Swiss-Prot
  BTB-kelch_protein UniProtKB/Swiss-Prot
  BTB/POZ_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KBTBD8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kelch-typ_b-propeller UniProtKB/Swiss-Prot
  Kelch_1 UniProtKB/Swiss-Prot
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:243574 UniProtKB/Swiss-Prot
MGD MGI:2661430 ENTREZGENE
NCBI Gene 243574 ENTREZGENE
PANTHER PTHR24412:SF433 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BACK UniProtKB/Swiss-Prot
  BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kelch_1 UniProtKB/Swiss-Prot
PhenoGen Kbtbd8 PhenoGen
PIRSF Kelch-like_protein_gigaxonin UniProtKB/Swiss-Prot
PROSITE BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BACK UniProtKB/Swiss-Prot
  BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kelch UniProtKB/Swiss-Prot
Superfamily-SCOP SSF117281 UniProtKB/Swiss-Prot
  SSF54695 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0N4SV97_MOUSE UniProtKB/TrEMBL
  KBTB8_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q3TJB2 UniProtKB/Swiss-Prot
  Q5M7B2 UniProtKB/Swiss-Prot
  Q8CH97 UniProtKB/Swiss-Prot