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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732752
Species: Mus musculus
RGD Object: Gene
Symbol: Nr4a1
Name: nuclear receptor subfamily 4, group A, member 1
Acc ID: CHEBI:10106
Term: zearalenone
Definition: A macrolide comprising a fourteen-membered lactone fused to 1,3-dihydroxybenzene; a potent estrogenic metabolite produced by some Giberella species.
Chemical ID: MESH:D015025
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr4a1decreases expressionEXP 6480464CTDZearalenone results in decreased expression of NR4A1 proteinPMID:24512812
Nr4a1increases expressionEXP 6480464CTDZearalenone results in increased expression of NR4A1 mRNAPMID:26783879
Nr4a1multiple interactionsEXP 6480464CTDColforsin promotes the reaction [Zearalenone results in increased expression of NR4A1 mRNA]PMID:26783879
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