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Gene: Nucb2 (nucleobindin 2) Mus musculus
Symbol: Nucb2
Name: nucleobindin 2
Description: Exhibits calcium ion binding activity. Predicted to be involved in several processes, including negative regulation of appetite; negative regulation of cell communication; and positive regulation of testosterone secretion. Localizes to endoplasmic reticulum and nuclear outer membrane. Is expressed in several structures, including extraembryonic component and female reproductive system. Orthologous to human NUCB2 (nucleobindin 2); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI607786; Calnuc; DNA-binding protein NEFA; Nefa; Nesfatin-1; nucleobindin-2; prepronefastin; prepronesfatin
Homo sapiens (human) : NUCB2 (nucleobindin 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Nucb2 (nucleobindin 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nucb2 (nucleobindin 2)
Pan paniscus (bonobo/pygmy chimpanzee) : NUCB2 (nucleobindin 2)
Canis lupus familiaris (dog) : NUCB2 (nucleobindin 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nucb2 (nucleobindin 2)
Sus scrofa (pig) : NUCB2 (nucleobindin 2)
Chlorocebus sabaeus (African green monkey) : NUCB2 (nucleobindin 2)
Heterocephalus glaber (naked mole-rat) : Nucb2 (nucleobindin 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl7116,504,369 - 116,540,584 (+)EnsemblGRCm38mm10GRCm38
GRCm387116,504,352 - 116,540,588 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv377123,647,888 - 123,684,102 (+)NCBIGRCm37mm9NCBIm37
MGSCv367116,295,518 - 116,331,703 (+)NCBImm8
Celera7116,437,745 - 116,475,120 (+)NCBICelera
Cytogenetic Map7F1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Nucb2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 734221
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.