Tlr3 (toll-like receptor 3) - Rat Genome Database

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Gene: Tlr3 (toll-like receptor 3) Mus musculus
Analyze
Symbol: Tlr3
Name: toll-like receptor 3
RGD ID: 1553513
MGI Page MGI
Description: Predicted to enable double-stranded RNA binding activity; identical protein binding activity; and signaling receptor activity. Involved in several processes, including JNK cascade; positive regulation of angiogenesis; and positive regulation of cytokine production. Acts upstream of or within several processes, including positive regulation of NF-kappaB transcription factor activity; positive regulation of intracellular signal transduction; and regulation of cytokine production. Predicted to be located in cell surface and cytoplasm. Predicted to be integral component of plasma membrane. Is expressed in brain; cerebral cortex; cerebral cortex ventricular layer; forebrain; and submandibular gland primordium. Human ortholog(s) of this gene implicated in several diseases, including hepatitis B; hepatitis C; human immunodeficiency virus infectious disease; liver cirrhosis; and type 1 diabetes mellitus. Orthologous to human TLR3 (toll like receptor 3); PARTICIPATES IN Toll-like receptor signaling pathway; hepatitis C pathway; influenza A pathway; INTERACTS WITH (-)-citrinin; 1,2-dimethylhydrazine; 3-phenylprop-2-enal.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI957183
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39845,848,702 - 45,864,112 (-)NCBIGRCm39mm39
GRCm39 Ensembl845,848,702 - 45,864,117 (-)Ensembl
GRCm38845,395,665 - 45,411,075 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl845,395,665 - 45,411,080 (-)EnsemblGRCm38mm10GRCm38
MGSCv37846,481,019 - 46,495,893 (-)NCBIGRCm37mm9NCBIm37
MGSCv36846,894,482 - 46,909,356 (-)NCBImm8
Celera848,083,156 - 48,098,074 (-)NCBICelera
Cytogenetic Map8B1.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-citrinin  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (EXP)
1-nitropyrene  (ISO)
17beta-estradiol  (ISO)
2,4-dinitrotoluene  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-phenylprop-2-enal  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
aripiprazole  (ISO)
arsenous acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bisdemethoxycurcumin  (ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
cadmium selenide  (ISO)
calcitriol  (ISO)
carbon nanotube  (EXP,ISO)
chlorogenic acid  (EXP)
chloroquine  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
cyanidin cation  (EXP,ISO)
cyclosporin A  (ISO)
deoxynivalenol  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
ethanol  (EXP,ISO)
folic acid  (ISO)
GW 4064  (EXP)
hydroquinone  (ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
lipopolysaccharide  (EXP,ISO)
metam  (EXP)
metformin  (ISO)
methamphetamine  (EXP)
methotrexate  (ISO)
nickel sulfate  (ISO)
nitrates  (ISO)
o-anisidine  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
poly(I:C)  (EXP,ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
pristane  (ISO)
pyrene  (ISO)
quinacrine  (ISO)
resveratrol  (EXP)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
sodium arsenite  (ISO)
sodium aurothiosulfate  (ISO)
streptozocin  (EXP,ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
triclosan  (ISO)
trimellitic anhydride  (EXP)
triptonide  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to exogenous dsRNA  (ISO)
cellular response to interferon-beta  (ISO)
cellular response to interferon-gamma  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to virus  (IMP)
cellular response to xenobiotic stimulus  (ISO)
defense response  (IMP)
defense response to virus  (IGI,TAS)
extrinsic apoptotic signaling pathway  (ISO)
I-kappaB phosphorylation  (ISO)
immune response  (IEA)
immune system process  (IEA)
inflammatory response  (IBA)
innate immune response  (TAS)
JNK cascade  (IMP)
male gonad development  (ISO)
MAPK cascade  (IMP)
microglial cell activation  (ISO)
MyD88-independent toll-like receptor signaling pathway  (IEA)
necroptotic signaling pathway  (ISO)
positive regulation of angiogenesis  (IGI)
positive regulation of apoptotic process  (ISO)
positive regulation of chemokine production  (IMP,ISO)
positive regulation of cytokine production  (IEA)
positive regulation of gene expression  (ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (IDA,IGI,IMP)
positive regulation of inflammatory response  (IEA)
positive regulation of interferon-alpha production  (ISO)
positive regulation of interferon-beta production  (IDA,ISO,ISS)
positive regulation of interferon-gamma production  (ISO)
positive regulation of interleukin-12 production  (IDA)
positive regulation of interleukin-6 production  (IDA,IMP,ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of JNK cascade  (IDA)
positive regulation of NF-kappaB transcription factor activity  (IMP)
positive regulation of NIK/NF-kappaB signaling  (ISO)
positive regulation of toll-like receptor signaling pathway  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IGI)
positive regulation of tumor necrosis factor production  (IDA,IMP)
positive regulation of type I interferon production  (IDA)
positive regulation of type III interferon production  (IDA)
regulation of dendritic cell cytokine production  (IDA)
response to dsRNA  (ISO)
response to exogenous dsRNA  (IMP,ISO)
response to virus  (IMP,ISO)
signal transduction  (IEA)
toll-like receptor 3 signaling pathway  (IEA)
toll-like receptor signaling pathway  (IBA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal axon morphology  (IAGP)
abnormal B cell physiology  (IAGP)
abnormal cytokine level  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal dendritic cell physiology  (IAGP)
abnormal dentate gyrus morphology  (IAGP)
abnormal emotion/affect behavior  (IAGP)
abnormal fear-related response  (IAGP)
abnormal hippocampus CA1 region morphology  (IAGP)
abnormal hippocampus development  (IAGP)
abnormal interferon level  (IAGP)
abnormal interleukin level  (IAGP)
abnormal learning/memory/conditioning  (IAGP)
abnormal long term spatial reference memory  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal neuron physiology  (IAGP)
abnormal NK cell physiology  (IAGP)
abnormal NK T cell physiology  (IAGP)
abnormal pancreatic beta cell physiology  (IAGP)
abnormal pancreatic islet morphology  (IAGP)
abnormal postimplantation uterine environment  (IAGP)
abnormal pregnancy  (IAGP)
abnormal respiratory function  (IAGP)
abnormal respiratory system physiology  (IAGP)
abnormal response to novel object  (IAGP)
abnormal righting response  (IAGP)
abnormal spatial working memory  (IAGP)
abnormal tumor necrosis factor level  (IAGP)
abnormal vascular smooth muscle physiology  (IAGP)
abnormal vascular wound healing  (IAGP)
decreased anxiety-related response  (IAGP)
decreased fear-related response  (IAGP)
decreased inflammatory response  (IAGP)
decreased interferon-alpha secretion  (IAGP)
decreased interferon-beta secretion  (IAGP)
decreased macrophage cytokine production  (IEA)
decreased pancreatic beta cell mass  (IAGP)
decreased susceptibility to Riboviria infection  (IAGP)
decreased susceptibility to Riboviria infection induced morbidity/mortality  (IAGP)
decreased tumor necrosis factor secretion  (IEA)
delayed wound healing  (IAGP)
heart inflammation  (IAGP)
hyperglycemia  (IAGP)
impaired coordination  (IAGP)
increased circulating troponin I level  (IAGP)
increased fear-related response  (IAGP)
increased pancreatic islet number  (IAGP)
increased susceptibility to Coronaviridae infection  (IAGP)
increased susceptibility to Herpesvirales infection  (IAGP)
increased susceptibility to Picornaviridae infection induced morbidity/mortality  (IAGP)
increased tumor incidence  (IAGP)
References

References - curated
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Additional References at PubMed
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PMID:17049055   PMID:17056560   PMID:17091495   PMID:17114424   PMID:17170125   PMID:17190817   PMID:17196665   PMID:17202381   PMID:17237405   PMID:17277123   PMID:17339421   PMID:17339472  
PMID:17339488   PMID:17347473   PMID:17372013   PMID:17390082   PMID:17404303   PMID:17452530   PMID:17456769   PMID:17463084   PMID:17502662   PMID:17572686   PMID:17573354   PMID:17638914  
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PMID:18174025   PMID:18180038   PMID:18207576   PMID:18223009   PMID:18250457   PMID:18256152   PMID:18261938   PMID:18287559   PMID:18295350   PMID:18322244   PMID:18354215   PMID:18362039  
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PMID:22046349   PMID:22048772   PMID:22072781   PMID:22114338   PMID:22123964   PMID:22124111   PMID:22147891   PMID:22184724   PMID:22189096   PMID:22260507   PMID:22262694   PMID:22278742  
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PMID:22986631   PMID:23019335   PMID:23042151   PMID:23123736   PMID:23142781   PMID:23151845   PMID:23209319   PMID:23209324   PMID:23255589   PMID:23267850   PMID:23271706   PMID:23290562  
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PMID:23761632   PMID:23762449   PMID:23795287   PMID:23844087   PMID:23850521   PMID:23960190   PMID:23986602   PMID:24019532   PMID:24036040   PMID:24038087   PMID:24058413   PMID:24070541  
PMID:24091496   PMID:24102120   PMID:24114535   PMID:24140513   PMID:24285719   PMID:24338782   PMID:24353176   PMID:24362933   PMID:24390148   PMID:24391503   PMID:24409099   PMID:24416163  
PMID:24462705   PMID:24486326   PMID:24524192   PMID:24526685   PMID:24572365   PMID:24598055   PMID:24637670   PMID:24698267   PMID:24729619   PMID:24736450   PMID:24752295   PMID:24783958  
PMID:24801628   PMID:24827856   PMID:24878639   PMID:24889626   PMID:24914679   PMID:24920846   PMID:25008929   PMID:25050810   PMID:25079212   PMID:25101306   PMID:25106857   PMID:25118157  
PMID:25152077   PMID:25181416   PMID:25188232   PMID:25229251   PMID:25253340   PMID:25260755   PMID:25264029   PMID:25305318   PMID:25326752   PMID:25378393   PMID:25422874   PMID:25452586  
PMID:25539593   PMID:25564448   PMID:25633775   PMID:25681338   PMID:25692975   PMID:25736436   PMID:25756897   PMID:25780039   PMID:25828701   PMID:25897174   PMID:25911242   PMID:25918231  
PMID:25937283   PMID:25964372   PMID:26015500   PMID:26030851   PMID:26040668   PMID:26076314   PMID:26101320   PMID:26159724   PMID:26253200   PMID:26255864   PMID:26292317   PMID:26350376  
PMID:26363072   PMID:26385519   PMID:26392463   PMID:26470915   PMID:26494305   PMID:26508631   PMID:26508745   PMID:26579632   PMID:26581984   PMID:26595890   PMID:26603638   PMID:26633895  
PMID:26676850   PMID:26793623   PMID:26831104   PMID:26885867   PMID:26911613   PMID:26934179   PMID:27046485   PMID:27084119   PMID:27226571   PMID:27405980   PMID:27459510   PMID:27477784  
PMID:27505671   PMID:27509078   PMID:27542117   PMID:27560112   PMID:27586271   PMID:27593513   PMID:27606421   PMID:27643721   PMID:27716849   PMID:27727398   PMID:27771719   PMID:27793594  
PMID:27810922   PMID:27830702   PMID:27911948   PMID:27916941   PMID:27979975   PMID:28049762   PMID:28111081   PMID:28166388   PMID:28198368   PMID:28273893   PMID:28300057   PMID:28400473  
PMID:28410990   PMID:28411188   PMID:28416600   PMID:28464285   PMID:28479599   PMID:28495119   PMID:28564605   PMID:28607148   PMID:28612840   PMID:28662082   PMID:28768728   PMID:28774595  
PMID:28807557   PMID:28945004   PMID:28970238   PMID:29041928   PMID:29330412   PMID:29358670   PMID:29410095   PMID:29438518   PMID:29465830   PMID:29520027   PMID:29555782   PMID:29571298  
PMID:29576482   PMID:29624589   PMID:29632368   PMID:29676038   PMID:29768176   PMID:29777026   PMID:29798841   PMID:29879406   PMID:30177045   PMID:30201994   PMID:30209176   PMID:30209397  
PMID:30246036   PMID:30248373   PMID:30337928   PMID:30364002   PMID:30404733   PMID:30442666   PMID:30481825   PMID:30510167   PMID:30550785   PMID:30550930   PMID:30550931   PMID:30563052  
PMID:30571996   PMID:30583980   PMID:30625140   PMID:30635240   PMID:30642981   PMID:30670552   PMID:30683700   PMID:30811246   PMID:30906301   PMID:30989399   PMID:30997942   PMID:31067281  
PMID:31076723   PMID:31089414   PMID:31243280   PMID:31277274   PMID:31293597   PMID:31350848   PMID:31388100   PMID:31554802   PMID:31562213   PMID:31562937   PMID:31619538   PMID:31729371  
PMID:31754185   PMID:31801911   PMID:31827178   PMID:31852751   PMID:31865314   PMID:31910261   PMID:32040169   PMID:32133501   PMID:32150572   PMID:32209688   PMID:32325033   PMID:32515732  
PMID:32539223   PMID:32631940   PMID:32730309   PMID:32810576   PMID:32878999   PMID:32999457   PMID:33109186   PMID:33148715   PMID:33203755   PMID:33432245   PMID:33452626   PMID:33519804  
PMID:33521935   PMID:33558485   PMID:33965533   PMID:34206257   PMID:34211474  


Genomics

Comparative Map Data
Tlr3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39845,848,702 - 45,864,112 (-)NCBIGRCm39mm39
GRCm39 Ensembl845,848,702 - 45,864,117 (-)Ensembl
GRCm38845,395,665 - 45,411,075 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl845,395,665 - 45,411,080 (-)EnsemblGRCm38mm10GRCm38
MGSCv37846,481,019 - 46,495,893 (-)NCBIGRCm37mm9NCBIm37
MGSCv36846,894,482 - 46,909,356 (-)NCBImm8
Celera848,083,156 - 48,098,074 (-)NCBICelera
Cytogenetic Map8B1.1NCBI
TLR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4186,069,155 - 186,088,073 (+)EnsemblGRCh38hg38GRCh38
GRCh384186,069,156 - 186,088,073 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh374186,990,310 - 187,009,227 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364187,227,303 - 187,243,246 (+)NCBINCBI36hg18NCBI36
Build 344187,365,457 - 187,381,399NCBI
Celera4184,312,848 - 184,328,791 (+)NCBI
Cytogenetic Map4q35.1NCBI
HuRef4182,742,451 - 182,758,393 (+)NCBIHuRef
CHM1_14186,966,756 - 186,982,686 (+)NCBICHM1_1
Tlr3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21646,821,980 - 46,837,900 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1646,822,039 - 46,836,545 (+)Ensembl
Rnor_6.01650,016,466 - 50,031,011 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1650,016,857 - 50,031,214 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01649,739,814 - 49,753,968 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41650,112,910 - 50,126,371 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11650,112,984 - 50,126,440 (+)NCBI
Celera1644,813,138 - 44,826,566 (+)NCBICelera
Cytogenetic Map16q11NCBI
Tlr3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540322,979,120 - 23,001,467 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540322,977,882 - 23,001,392 (-)NCBIChiLan1.0ChiLan1.0
TLR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14190,446,487 - 190,462,728 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4190,446,487 - 190,462,728 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04178,238,352 - 178,256,264 (+)NCBIMhudiblu_PPA_v0panPan3
TLR3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11644,617,012 - 44,633,591 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1644,550,846 - 44,653,247 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1645,103,720 - 45,132,454 (-)NCBI
ROS_Cfam_1.01646,830,974 - 46,859,705 (-)NCBI
UMICH_Zoey_3.11644,798,956 - 44,827,679 (-)NCBI
UNSW_CanFamBas_1.01645,411,963 - 45,440,690 (-)NCBI
UU_Cfam_GSD_1.01645,543,452 - 45,571,950 (-)NCBI
Tlr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494334,721,792 - 34,740,517 (+)NCBI
SpeTri2.0NW_0049365543,370,766 - 3,388,125 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TLR3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1546,966,040 - 47,058,734 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11546,966,262 - 46,977,774 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21553,839,254 - 53,852,671 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TLR3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17131,991,068 - 132,014,366 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl7131,991,029 - 132,016,232 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037112,309,987 - 112,333,459 (+)NCBIVero_WHO_p1.0
Tlr3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476916,925,969 - 16,945,250 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
AI957183  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38845,396,122 - 45,396,224UniSTSGRCm38
MGSCv37846,481,476 - 46,481,578UniSTSGRCm37
Celera848,083,613 - 48,083,715UniSTS
Cytogenetic Map8B2UniSTS
Cytogenetic Map8A4UniSTS
Whitehead/MRC_RH8539.05UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81472316071045600Mouse
1301088Alcw6_malcohol withdrawal 6 (mouse)Not determined81501654449016701Mouse
1300912Daq19_mdirectional asymmetry QTL 19 (mouse)Not determined81501654449016701Mouse
1301298Pgia4_mproteoglycan induced arthritis 4 (mouse)Not determined81607934550079669Mouse
1301550Fembrs2_mfemur breaking strength 2 (mouse)Not determined81785394351854071Mouse
1301160Eae14_msusceptibility to experimental allergic encephalomyelitis 14 (mouse)Not determined81898786452987996Mouse
1300603Cd8ts2_mCD8 T cell subset 2 (mouse)Not determined81898786452987996Mouse
10043974Obq30_mobesity QTL 30 (mouse)Not determined82613028560130285Mouse
1357811Orq3_movulation rate QTL 3 (mouse)Not determined83201654471287993Mouse
4141437W10q14_mweight 10 weeks QTL 14 (mouse)Not determined3201654471287993Mouse
4141172W6q9_mweight 6 weeks QTL 9 (mouse)Not determined3201654471287993Mouse
4140966Egq12_mearly growth QTL 12 (mouse)Not determined3201654471287993Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
10043990Hbnr12_mHeligmosomoides bakeri nematode resistance 12 (mouse)Not determined83278698850837502Mouse
1301936Trigq2_mtriglyceride QTL 2 (mouse)Not determined83383736267837502Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301139Lmr10_mleishmaniasis resistance 10 (mouse)Not determined83485394357344598Mouse
11041902Lmr10a_mleishmaniasis resistance 10a (mouse)83485394357344598Mouse
11049577Lmr10b_mleishmaniasis resistance 10b (mouse)83485394357344598Mouse
11049578Lmr10c_mleishmaniasis resistance 10c (mouse)83485394357344598Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84429488078295025Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:629
Count of miRNA genes:261
Interacting mature miRNAs:295
Transcripts:ENSMUST00000034056, ENSMUST00000167106
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001357316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001357317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_126166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006509278 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006509279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006509280 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006509281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006509283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC116861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC120003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF355152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF420279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK083977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK087739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK166177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC023850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC099937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY770706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000034056   ⟹   ENSMUSP00000034056
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl845,848,702 - 45,863,656 (-)Ensembl
GRCm38.p6 Ensembl845,395,665 - 45,410,619 (-)Ensembl
RefSeq Acc Id: ENSMUST00000167106   ⟹   ENSMUSP00000126556
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl845,848,821 - 45,863,656 (-)Ensembl
GRCm38.p6 Ensembl845,395,784 - 45,410,619 (-)Ensembl
RefSeq Acc Id: ENSMUST00000209269
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl845,862,857 - 45,864,117 (-)Ensembl
GRCm38.p6 Ensembl845,409,820 - 45,411,080 (-)Ensembl
RefSeq Acc Id: ENSMUST00000209651   ⟹   ENSMUSP00000147961
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl845,856,157 - 45,863,595 (-)Ensembl
GRCm38.p6 Ensembl845,403,120 - 45,410,558 (-)Ensembl
RefSeq Acc Id: ENSMUST00000209772   ⟹   ENSMUSP00000147738
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl845,848,915 - 45,863,417 (-)Ensembl
GRCm38.p6 Ensembl845,395,878 - 45,410,380 (-)Ensembl
RefSeq Acc Id: ENSMUST00000210013   ⟹   ENSMUSP00000147783
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl845,848,907 - 45,851,323 (-)Ensembl
GRCm38.p6 Ensembl845,395,870 - 45,398,286 (-)Ensembl
RefSeq Acc Id: ENSMUST00000210354
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl845,862,881 - 45,863,414 (-)Ensembl
GRCm38.p6 Ensembl845,409,844 - 45,410,377 (-)Ensembl
RefSeq Acc Id: ENSMUST00000210996   ⟹   ENSMUSP00000148263
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl845,856,133 - 45,863,413 (-)Ensembl
GRCm38.p6 Ensembl845,403,096 - 45,410,376 (-)Ensembl
RefSeq Acc Id: ENSMUST00000211370   ⟹   ENSMUSP00000148127
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl845,855,900 - 45,863,655 (-)Ensembl
GRCm38.p6 Ensembl845,402,863 - 45,410,618 (-)Ensembl
RefSeq Acc Id: NM_001357316   ⟹   NP_001344245
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39845,848,702 - 45,863,417 (-)NCBI
GRCm38845,395,665 - 45,410,380 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001357317   ⟹   NP_001344246
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39845,848,702 - 45,863,656 (-)NCBI
GRCm38845,395,665 - 45,410,619 (-)NCBI
Sequence:
RefSeq Acc Id: NM_126166   ⟹   NP_569054
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39845,848,702 - 45,863,656 (-)NCBI
GRCm38845,395,665 - 45,410,619 (-)NCBI
MGSCv37846,481,019 - 46,495,893 (-)RGD
Celera848,083,156 - 48,098,074 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006509278   ⟹   XP_006509341
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39845,848,807 - 45,863,473 (-)NCBI
GRCm38845,395,770 - 45,410,443 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006509279   ⟹   XP_006509342
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39845,848,807 - 45,864,112 (-)NCBI
GRCm38845,395,770 - 45,411,075 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006509280   ⟹   XP_006509343
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39845,848,807 - 45,863,882 (-)NCBI
GRCm38845,395,770 - 45,410,851 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006509281   ⟹   XP_006509344
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39845,848,807 - 45,863,473 (-)NCBI
GRCm38845,395,770 - 45,410,443 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006509283   ⟹   XP_006509346
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39845,848,807 - 45,863,473 (-)NCBI
GRCm38845,395,770 - 45,410,443 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_569054   ⟸   NM_126166
- Peptide Label: precursor
- UniProtKB: Q99MB1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006509342   ⟸   XM_006509279
- Peptide Label: isoform X1
- UniProtKB: Q99MB1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006509343   ⟸   XM_006509280
- Peptide Label: isoform X1
- UniProtKB: Q99MB1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006509344   ⟸   XM_006509281
- Peptide Label: isoform X1
- UniProtKB: Q99MB1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006509346   ⟸   XM_006509283
- Peptide Label: isoform X1
- UniProtKB: Q99MB1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006509341   ⟸   XM_006509278
- Peptide Label: isoform X1
- UniProtKB: Q99MB1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001344246   ⟸   NM_001357317
- Peptide Label: precursor
RefSeq Acc Id: NP_001344245   ⟸   NM_001357316
- Peptide Label: precursor
RefSeq Acc Id: ENSMUSP00000034056   ⟸   ENSMUST00000034056
RefSeq Acc Id: ENSMUSP00000148127   ⟸   ENSMUST00000211370
RefSeq Acc Id: ENSMUSP00000148263   ⟸   ENSMUST00000210996
RefSeq Acc Id: ENSMUSP00000147783   ⟸   ENSMUST00000210013
RefSeq Acc Id: ENSMUSP00000126556   ⟸   ENSMUST00000167106
RefSeq Acc Id: ENSMUSP00000147738   ⟸   ENSMUST00000209772
RefSeq Acc Id: ENSMUSP00000147961   ⟸   ENSMUST00000209651
Protein Domains
LRRCT   LRRNT   TIR

Promoters
RGD ID:8666995
Promoter ID:EPDNEW_M11528
Type:initiation region
Name:Tlr3_2
Description:Mus musculus toll-like receptor 3 , transcript variant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M11529  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38845,409,898 - 45,409,958EPDNEW
RGD ID:8666997
Promoter ID:EPDNEW_M11529
Type:initiation region
Name:Tlr3_1
Description:Mus musculus toll-like receptor 3 , transcript variant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M11528  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38845,410,336 - 45,410,396EPDNEW
RGD ID:6849262
Promoter ID:MM_XEF:7043
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_4Hour
Transcripts:NM_198791
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36846,494,926 - 46,495,426 (-)MPROMDB
RGD ID:6843805
Promoter ID:MM_KWN:54300
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_126166,   UC009LOY.1,   UC009LPA.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36846,495,536 - 46,496,036 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2156367 AgrOrtholog
Ensembl Genes ENSMUSG00000031639 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000034056 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000126556 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000147738 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000147783 UniProtKB/TrEMBL
  ENSMUSP00000147961 UniProtKB/TrEMBL
  ENSMUSP00000148127 UniProtKB/TrEMBL
  ENSMUSP00000148263 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000034056 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000167106 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000209651 UniProtKB/TrEMBL
  ENSMUST00000209772 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000210013 UniProtKB/TrEMBL
  ENSMUST00000210996 UniProtKB/TrEMBL
  ENSMUST00000211370 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10140 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cys-rich_flank_reg_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TLR3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TLR3_TMD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Toll-like_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Toll_tir_struct_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:142980 UniProtKB/Swiss-Prot
MGD MGI:2156367 ENTREZGENE
NCBI Gene 142980 ENTREZGENE
PANTHER PTHR24365 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24365:SF524 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam LRR_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tlr3_TMD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tlr3 PhenoGen
PROSITE LRR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART LRR_TYP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1B0GS40_MOUSE UniProtKB/TrEMBL
  A0A1B0GSY9_MOUSE UniProtKB/TrEMBL
  A0A1B0GTA2_MOUSE UniProtKB/TrEMBL
  A0A1Y7VI41_MOUSE UniProtKB/TrEMBL
  Q3TM31_MOUSE UniProtKB/TrEMBL
  Q499F3_MOUSE UniProtKB/TrEMBL
  Q8C2X8_MOUSE UniProtKB/TrEMBL
  Q99MB1 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q91ZM4 UniProtKB/Swiss-Prot