Tlr3 (toll-like receptor 3) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Tlr3 (toll-like receptor 3) Mus musculus
Analyze
Symbol: Tlr3
Name: toll-like receptor 3
RGD ID: 1553513
MGI Page MGI
Description: Enables pattern recognition receptor activity; transmembrane signaling receptor activity; and ubiquitin-like protein ligase binding activity. Involved in several processes, including JNK cascade; positive regulation of macromolecule biosynthetic process; and response to virus. Acts upstream of or within several processes, including cellular response to exogenous dsRNA; positive regulation of intracellular signal transduction; and regulation of cytokine production. Is active in plasma membrane. Is expressed in blood; brain; and submandibular gland primordium. Human ortholog(s) of this gene implicated in asthma; human immunodeficiency virus infectious disease; liver disease (multiple); and primary immunodeficiency disease (multiple). Orthologous to human TLR3 (toll like receptor 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI957183
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39845,848,702 - 45,864,112 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl845,848,702 - 45,864,117 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38845,395,665 - 45,411,075 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl845,395,665 - 45,411,080 (-)Ensemblmm10GRCm38
MGSCv37846,481,019 - 46,495,893 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36846,894,482 - 46,909,356 (-)NCBIMGSCv36mm8
Celera848,083,156 - 48,098,074 (-)NCBICelera
Cytogenetic Map8B1.1NCBI
cM Map825.31NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-citrinin  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (EXP)
1-Aminopyrene  (ISO)
1-nitropyrene  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-phenylprop-2-enal  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
aripiprazole  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
cadmium selenide  (ISO)
calcitriol  (ISO)
carbon nanotube  (EXP,ISO)
chenodeoxycholic acid  (ISO)
chlorogenic acid  (EXP)
chloroquine  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
cyanidin cation  (EXP,ISO)
cyclosporin A  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
folic acid  (ISO)
gentamycin  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
GW 4064  (EXP)
hydroquinone  (ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
lidocaine  (ISO)
lipopolysaccharide  (EXP,ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
metam  (EXP)
metformin  (ISO)
methamphetamine  (EXP)
methotrexate  (ISO)
methoxychlor  (ISO)
nickel sulfate  (ISO)
nitrates  (ISO)
Nutlin-3  (ISO)
o-anisidine  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentachlorophenol  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
poly(I:C)  (EXP,ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
pristane  (ISO)
pyrene  (ISO)
quinacrine  (ISO)
resveratrol  (EXP)
ruxolitinib  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
sodium arsenate  (EXP)
sodium arsenite  (ISO)
sodium aurothiosulfate  (ISO)
sotorasib  (ISO)
streptozocin  (EXP,ISO)
Sunset Yellow FCF  (ISO)
tartrazine  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
trametinib  (ISO)
triclosan  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
triptonide  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to exogenous dsRNA  (IDA,ISO)
cellular response to interferon-beta  (ISO)
cellular response to mechanical stimulus  (IEA)
cellular response to type II interferon  (ISO)
cellular response to virus  (IMP)
cellular response to xenobiotic stimulus  (ISO)
defense response  (IMP)
defense response to virus  (IDA,IEA,IGI)
extrinsic apoptotic signaling pathway  (IEA,ISO)
immune system process  (IEA)
inflammatory response  (IBA,IEA)
inflammatory response to wounding  (IDA,IEA,ISO)
innate immune response  (IDA,IEA)
intracellular signal transduction  (IEA)
JNK cascade  (IMP)
male gonad development  (ISO)
MAPK cascade  (IMP)
microglial cell activation  (ISO)
necroptotic signaling pathway  (IEA,ISO)
positive regulation of angiogenesis  (IGI)
positive regulation of apoptotic process  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (IDA,IEA,IGI,IMP,ISO)
positive regulation of chemokine production  (IEA,IMP,ISO)
positive regulation of cytokine production involved in inflammatory response  (IDA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of immune system process  (IEA)
positive regulation of inflammatory response  (IEA,ISO)
positive regulation of interferon-alpha production  (IEA,ISO,ISS)
positive regulation of interferon-beta production  (IDA,IEA,ISO,ISS)
positive regulation of interleukin-12 production  (IDA)
positive regulation of interleukin-6 production  (IDA,IEA,IMP,ISO)
positive regulation of interleukin-8 production  (IEA,ISO)
positive regulation of JNK cascade  (IDA,IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IGI)
positive regulation of tumor necrosis factor production  (IDA,IMP)
positive regulation of type I interferon production  (IDA)
positive regulation of type II interferon production  (IEA,ISO,ISS)
positive regulation of type III interferon production  (IDA)
regulation of dendritic cell cytokine production  (IDA)
regulation of toll-like receptor 3 signaling pathway  (ISO)
response to dsRNA  (ISO)
response to exogenous dsRNA  (IEA,IMP,ISO)
response to virus  (IMP)
signal transduction  (IEA)
toll-like receptor 3 signaling pathway  (IEA,ISO)
toll-like receptor signaling pathway  (IBA,IEA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal axon morphology  (IAGP)
abnormal B cell physiology  (IAGP)
abnormal cytokine level  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal dendritic cell physiology  (IAGP)
abnormal dentate gyrus morphology  (IAGP)
abnormal emotion/affect behavior  (IAGP)
abnormal fear-related response  (IAGP)
abnormal hippocampus CA1 region morphology  (IAGP)
abnormal hippocampus development  (IAGP)
abnormal interferon level  (IAGP)
abnormal interleukin level  (IAGP)
abnormal learning/memory/conditioning  (IAGP)
abnormal long-term spatial reference memory  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal neuron physiology  (IAGP)
abnormal NK cell physiology  (IAGP)
abnormal NK T cell physiology  (IAGP)
abnormal pancreatic beta cell physiology  (IAGP)
abnormal pancreatic islet morphology  (IAGP)
abnormal postimplantation uterine environment  (IAGP)
abnormal pregnancy  (IAGP)
abnormal respiratory function  (IAGP)
abnormal respiratory system physiology  (IAGP)
abnormal response to novel object  (IAGP)
abnormal righting response  (IAGP)
abnormal spatial working memory  (IAGP)
abnormal tumor necrosis factor level  (IAGP)
abnormal vascular smooth muscle physiology  (IAGP)
abnormal vascular wound healing  (IAGP)
decreased anxiety-related response  (IAGP)
decreased fear-related response  (IAGP)
decreased inflammatory response  (IAGP)
decreased interferon-alpha secretion  (IAGP)
decreased interferon-beta secretion  (IAGP)
decreased macrophage cytokine production  (IEA)
decreased pancreatic beta cell mass  (IAGP)
decreased susceptibility to Riboviria infection  (IAGP)
decreased susceptibility to Riboviria infection induced morbidity/mortality  (IAGP)
decreased tumor necrosis factor secretion  (IEA)
delayed wound healing  (IAGP)
heart inflammation  (IAGP)
hyperglycemia  (IAGP)
impaired coordination  (IAGP)
increased circulating troponin I level  (IAGP)
increased fear-related response  (IAGP)
increased pancreatic islet number  (IAGP)
increased susceptibility to Coronaviridae infection  (IAGP)
increased susceptibility to Herpesvirales infection  (IAGP)
increased susceptibility to Picornaviridae infection induced morbidity/mortality  (IAGP)
increased tumor incidence  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Toll-like receptor 3 gene expression in Egyptian patients with glomerulonephritis and hepatitis C virus infection. Abou-Zeid AA and El-Sayegh HK, Scand J Clin Lab Invest. 2011 Oct;71(6):456-61. doi: 10.3109/00365513.2011.585660. Epub 2011 May 30.
2. Toll-like receptor 3 polymorphism and its association with hepatitis B virus infection in Saudi Arabian patients. Al-Qahtani A, etal., J Med Virol. 2012 Sep;84(9):1353-9. doi: 10.1002/jmv.23271.
3. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Alexopoulou L, etal., Nature 2001 Oct 18;413(6857):732-8.
4. Activation of toll-like receptor 3 attenuates alcoholic liver injury by stimulating Kupffer cells and stellate cells to produce interleukin-10 in mice. Byun JS, etal., J Hepatol. 2013 Feb;58(2):342-9. doi: 10.1016/j.jhep.2012.09.016. Epub 2012 Sep 27.
5. Toll-like receptor 3 expressing tumor parenchyma and infiltrating natural killer cells in hepatocellular carcinoma patients. Chew V, etal., J Natl Cancer Inst. 2012 Dec 5;104(23):1796-807. doi: 10.1093/jnci/djs436. Epub 2012 Nov 29.
6. Rapidity of fibrosis progression in liver transplant recipients with recurrent hepatitis C is influenced by toll-like receptor 3 polymorphism. Citores MJ, etal., Clin Transplant. 2016 Jul;30(7):810-8. doi: 10.1111/ctr.12754. Epub 2016 May 23.
7. High Mobility Group Box 1/Toll-like Receptor Danger Signaling Increases Brain Neuroimmune Activation in Alcohol Dependence. Crews FT, etal., Biol Psychiatry. 2012 Nov 30. pii: S0006-3223(12)00889-X. doi: 10.1016/j.biopsych.2012.09.030.
8. Association between toll-like receptor expression and human papillomavirus type 16 persistence. Daud II, etal., Int J Cancer. 2011 Feb 15;128(4):879-86. doi: 10.1002/ijc.25400.
9. The association of single nucleotide polymorphisms of Toll-like receptor 3, Toll-like receptor 7 and Toll-like receptor 8 genes with the susceptibility to HCV infection. El-Bendary M, etal., Br J Biomed Sci. 2018 Oct;75(4):175-181. doi: 10.1080/09674845.2018.1492186. Epub 2018 Aug 23.
10. Polymorphisms in the Toll-like receptor 3 (TLR3) gene are associated with the natural course of hepatitis B virus infection in Caucasian population. Fischer J, etal., Sci Rep. 2018 Aug 24;8(1):12737. doi: 10.1038/s41598-018-31065-6.
11. Up-regulation of Toll-like receptors 2, 3 and 4 in allergic rhinitis. Fransson M, etal., Respir Res. 2005 Sep 7;6:100.
12. Pre-activation of TLR3 enhances the therapeutic effect of BMMSCs through regulation the intestinal HIF-2α signaling pathway and balance of NKB cells in experimental alcoholic liver injury. Ge L, etal., Int Immunopharmacol. 2019 May;70:477-485. doi: 10.1016/j.intimp.2019.02.021. Epub 2019 Mar 12.
13. A murine model of mixed connective tissue disease induced with U1 small nuclear RNP autoantigen. Greidinger EL, etal., Arthritis Rheum. 2006 Feb;54(2):661-9.
14. Combinations of TLR and NOD2 ligands stimulate rat microglial P2X4R expression. Guo LH, etal., Biochem Biophys Res Commun. 2006 Oct 27;349(3):1156-62. Epub 2006 Sep 1.
15. Association of Toll-like receptor 3 and Toll-like receptor 9 single-nucleotide polymorphisms with hepatitis C virus persistence among Egyptians. Hamdy S, etal., Arch Virol. 2018 Sep;163(9):2433-2442. doi: 10.1007/s00705-018-3893-8. Epub 2018 Jun 2.
16. Thyrocytes express a functional toll-like receptor 3: overexpression can be induced by viral infection and reversed by phenylmethimazole and is associated with Hashimoto's autoimmune thyroiditis. Harii N, etal., Mol Endocrinol. 2005 May;19(5):1231-50. Epub 2005 Jan 20.
17. A tropomyosine receptor kinase inhibitor blocks spinal neuroplasticity essential for the anti-hypersensitivity effects of gabapentin and clonidine in rats with peripheral nerve injury. Hayashida K and Eisenach JC, J Pain. 2011 Jan;12(1):94-100.
18. Epithelial Cells From Smokers Modify Dendritic Cell Responses in the Context of Influenza Infection. Horvath KM, etal., Am J Respir Cell Mol Biol. 2010 Oct 8.
19. Genetic polymorphisms in Toll-like receptor 3 gene are associated with the risk of hepatitis B virus-related liver diseases in a Chinese population. Huang X, etal., Gene. 2015 Sep 15;569(2):218-24. doi: 10.1016/j.gene.2015.05.054. Epub 2015 May 27.
20. TLR3 increases disease morbidity and mortality from vaccinia infection. Hutchens M, etal., J Immunol. 2008 Jan 1;180(1):483-91.
21. TH2 and TH1 lung inflammation induced by airway allergen sensitization with low and high doses of double-stranded RNA. Jeon SG, etal., J Allergy Clin Immunol. 2007 Oct;120(4):803-12. Epub 2007 Jul 5.
22. TLR3 modulates immunopathology during a Schistosoma mansoni egg-driven Th2 response in the lung. Joshi AD, etal., Eur J Immunol. 2008 Dec;38(12):3436-49.
23. Melatonin protects liver against ischemia and reperfusion injury through inhibition of toll-like receptor signaling pathway. Kang JW, etal., J Pineal Res. 2011 Feb 28. doi: 10.1111/j.1600-079X.2011.00858.x.
24. Cigarette smoke selectively enhances viral PAMP- and virus-induced pulmonary innate immune and remodeling responses in mice. Kang MJ, etal., J Clin Invest. 2008 Aug;118(8):2771-84.
25. Down regulation of TRIF, TLR3, and MAVS in HCV infected liver correlates with the outcome of infection. Kar P, etal., J Med Virol. 2017 Dec;89(12):2165-2172. doi: 10.1002/jmv.24849. Epub 2017 Sep 4.
26. Pathogen recognition by the innate immune system. Kumar H, etal., Int Rev Immunol. 2011 Feb;30(1):16-34.
27. Detrimental contribution of the Toll-like receptor (TLR)3 to influenza A virus-induced acute pneumonia. Le Goffic R, etal., PLoS Pathog. 2006 Jun;2(6):e53. Epub 2006 Jun 9.
28. Association between a functional polymorphism in Toll-like receptor 3 and chronic hepatitis C in liver transplant recipients. Lee SO, etal., Transpl Infect Dis. 2013 Apr;15(2):111-9. doi: 10.1111/tid.12033. Epub 2012 Dec 13.
29. Higher expression of Toll-like receptors 2, 3, 4, and 8 in ocular Behcet's disease. Liu X, etal., Invest Ophthalmol Vis Sci. 2013 Sep 5;54(9):6012-7. doi: 10.1167/iovs.13-12159.
30. Changes in intestinal Toll-like receptors and cytokines precede histological injury in a rat model of necrotizing enterocolitis. Liu Y, etal., Am J Physiol Gastrointest Liver Physiol. 2009 Sep;297(3):G442-50. Epub 2009 Jul 16.
31. TLR3 in human eosinophils: functional effects and decreased expression during allergic rhinitis. Mansson A, etal., Int Arch Allergy Immunol. 2010;151(2):118-28. Epub 2009 Sep 15.
32. Toll-like receptor mRNA expression is selectively increased in the colonic mucosa of two animal models relevant to irritable bowel syndrome. McKernan DP, etal., PLoS One. 2009 Dec 9;4(12):e8226.
33. Toll-like receptor 3 upregulation in macrophages participates in the initiation and maintenance of pristane-induced arthritis in rats. Meng L, etal., Arthritis Res Ther. 2010;12(3):R103. Epub 2010 May 25.
34. TLR3 and TLR7 Modulate IgE Production in Antigen Induced Pulmonary Inflammation via Influencing IL-4 Expression in Immune Organs. Meng L, etal., PLoS One. 2011 Feb 25;6(2):e17252.
35. MGDs mouse GO annotations MGD data from the GO Consortium
36. MGD IEA MGD IEA
37. Association between Toll-Like Receptor 3 (TLR3) rs3775290, TLR7 rs179008, TLR9 rs352140 and Chronic HCV. Mosaad YM, etal., Immunol Invest. 2019 Apr;48(3):321-332. doi: 10.1080/08820139.2018.1527851. Epub 2018 Oct 15.
38. Deleterious role of TLR3 during hyperoxia-induced acute lung injury. Murray LA, etal., Am J Respir Crit Care Med. 2008 Dec 15;178(12):1227-37. Epub 2008 Oct 10.
39. An association study of asthma and total serum immunoglobin E levels for Toll-like receptor polymorphisms in a Japanese population. Noguchi E, etal., Clin Exp Allergy. 2004 Feb;34(2):177-83.
40. The expression and function of Toll-like receptors 3 and 9 in human colon carcinoma. Nojiri K, etal., Oncol Rep. 2013 May;29(5):1737-43. doi: 10.3892/or.2013.2322. Epub 2013 Mar 4.
41. The bacteriostatic protein lipocalin 2 is induced in the central nervous system of mice with west Nile virus encephalitis. Noçon AL, etal., J Virol. 2014 Jan;88(1):679-89. doi: 10.1128/JVI.02094-13. Epub 2013 Oct 30.
42. Toll-like receptor 3 contributes to spinal glial activation and tactile allodynia after nerve injury. Obata K, etal., J Neurochem. 2008 Jun 1;105(6):2249-59.
43. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
44. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
45. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
46. Toll-like receptor 3 gene polymorphisms in South African Blacks with type 1 diabetes. Pirie FJ, etal., Tissue Antigens. 2005 Aug;66(2):125-30.
47. Impaired toll-like receptor 3-mediated immune responses from macrophages of patients chronically infected with hepatitis C virus. Qian F, etal., Clin Vaccine Immunol. 2013 Feb;20(2):146-55. doi: 10.1128/CVI.00530-12. Epub 2012 Dec 5.
48. Spinal toll like receptor 3 is involved in chronic pancreatitis-induced mechanical allodynia of rat. Qian NS, etal., Mol Pain. 2011 Feb 22;7(1):15.
49. Effects of single nucleotide polymorphisms on Toll-like receptor 3 activity and expression in cultured cells. Ranjith-Kumar CT, etal., J Biol Chem. 2007 Jun 15;282(24):17696-705. Epub 2007 Apr 13.
50. Toll-like receptor expression and activation in mice with experimental dry eye. Redfern RL, etal., Invest Ophthalmol Vis Sci. 2013 Feb 28;54(2):1554-63. doi: 10.1167/iovs.12-10739.
51. Mouse MP Annotation Import Pipeline RGD automated import pipeline
52. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
53. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
54. Expression of toll-like receptors 2, 4 and 9 is increased in gingival tissue from patients with type 2 diabetes and chronic periodontitis. Rojo-Botello NR, etal., J Periodontal Res. 2012 Feb;47(1):62-73. doi: 10.1111/j.1600-0765.2011.01405.x. Epub 2011 Aug 17.
55. Association of Toll-like receptor 3 polymorphisms with chronic hepatitis B and hepatitis B-related acute-on-chronic liver failure. Rong Y, etal., Inflammation. 2013 Apr;36(2):413-8. doi: 10.1007/s10753-012-9560-4.
56. Deletion of TLR3 alters the pulmonary immune environment and mucus production during respiratory syncytial virus infection. Rudd BD, etal., J Immunol. 2006 Feb 1;176(3):1937-42.
57. Exosome-mediated activation of toll-like receptor 3 in stellate cells stimulates interleukin-17 production by γδ T cells in liver fibrosis. Seo W, etal., Hepatology. 2016 Aug;64(2):616-31. doi: 10.1002/hep.28644. Epub 2016 Jun 29.
58. Mechanistic investigation of immunosuppression in patients with condyloma acuminata. Shi YJ, etal., Mol Med Rep. 2013 Aug;8(2):480-6. doi: 10.3892/mmr.2013.1511. Epub 2013 Jun 6.
59. Toll-like receptor 3 activation during pregnancy elicits preeclampsia-like symptoms in rats. Tinsley JH, etal., Am J Hypertens. 2009 Dec;22(12):1314-9. Epub 2009 Sep 24.
60. Increased Toll-like Receptor-MyD88-NFκB-Proinflammatory neuroimmune signaling in the orbitofrontal cortex of humans with alcohol use disorder. Vetreno RP, etal., Alcohol Clin Exp Res. 2021 Sep;45(9):1747-1761. doi: 10.1111/acer.14669. Epub 2021 Aug 20.
61. Characterization of innate immune signalling receptors in virus-induced acute asthma. Wood LG, etal., Clin Exp Allergy. 2010 Dec 3. doi: 10.1111/j.1365-2222.2010.03669.x.
62. Hepatic Toll-Like Receptor 3 expression in chronic hepatitis C genotype 1 correlates with treatment response to peginterferon plus ribavirin. Yuki N, etal., J Viral Hepat. 2010 Feb 1;17(2):130-8. doi: 10.1111/j.1365-2893.2009.01155.x. Epub 2009 Aug 5.
63. Increase in peripheral blood mononuclear cell Toll-like receptor 2/3 expression and reactivity to their ligands in a cohort of patients with wet age-related macular degeneration. Zhu Y, etal., Mol Vis. 2013 Aug 6;19:1826-33. eCollection 2013.
Additional References at PubMed
PMID:2233742   PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11923871   PMID:12054664   PMID:12133979   PMID:12202403   PMID:12354379   PMID:12408049  
PMID:12477932   PMID:12646618   PMID:12672806   PMID:12819125   PMID:12855817   PMID:12960379   PMID:14625548   PMID:14976262   PMID:14993594   PMID:15064760   PMID:15100310   PMID:15110521  
PMID:15128790   PMID:15210814   PMID:15240691   PMID:15241362   PMID:15356140   PMID:15558055   PMID:15634897   PMID:15711573   PMID:15772251   PMID:15840693   PMID:15860593   PMID:16001129  
PMID:16027240   PMID:16105838   PMID:16141072   PMID:16141073   PMID:16142239   PMID:16143103   PMID:16210631   PMID:16237098   PMID:16244651   PMID:16260493   PMID:16272328   PMID:16301743  
PMID:16368889   PMID:16369915   PMID:16426495   PMID:16456008   PMID:16473828   PMID:16517751   PMID:16537810   PMID:16546102   PMID:16547251   PMID:16554027   PMID:16586493   PMID:16602821  
PMID:16616084   PMID:16625202   PMID:16714379   PMID:16751377   PMID:16782847   PMID:16886064   PMID:16920983   PMID:16936008   PMID:16955143   PMID:16985170   PMID:17008311   PMID:17027917  
PMID:17049055   PMID:17056560   PMID:17091495   PMID:17114424   PMID:17170125   PMID:17190817   PMID:17196665   PMID:17202381   PMID:17237405   PMID:17277123   PMID:17339421   PMID:17339472  
PMID:17339488   PMID:17347473   PMID:17372013   PMID:17390082   PMID:17404303   PMID:17452530   PMID:17456769   PMID:17463084   PMID:17502662   PMID:17572686   PMID:17573354   PMID:17638914  
PMID:17644803   PMID:17660379   PMID:17675254   PMID:17705137   PMID:17897860   PMID:17911381   PMID:17981792   PMID:17992263   PMID:17998391   PMID:18023390   PMID:18032677   PMID:18057004  
PMID:18174025   PMID:18180038   PMID:18207576   PMID:18223009   PMID:18250457   PMID:18256152   PMID:18261938   PMID:18287559   PMID:18295350   PMID:18322244   PMID:18354215   PMID:18362039  
PMID:18368052   PMID:18384880   PMID:18394314   PMID:18420935   PMID:18423196   PMID:18442983   PMID:18471880   PMID:18490751   PMID:18499758   PMID:18593942   PMID:18596219   PMID:18636103  
PMID:18650463   PMID:18715906   PMID:18725521   PMID:18779317   PMID:18802055   PMID:18838547   PMID:18971420   PMID:18981140   PMID:19017955   PMID:19017982   PMID:19047410   PMID:19074283  
PMID:19091986   PMID:19120284   PMID:19122179   PMID:19122812   PMID:19158348   PMID:19191335   PMID:19200758   PMID:19239422   PMID:19252739   PMID:19357791   PMID:19359485   PMID:19362356  
PMID:19382893   PMID:19426550   PMID:19441101   PMID:19445181   PMID:19451267   PMID:19474102   PMID:19486528   PMID:19535142   PMID:19559490   PMID:19570822   PMID:19596990   PMID:19710451  
PMID:19710456   PMID:19717524   PMID:19720755   PMID:19732955   PMID:19734906   PMID:19747951   PMID:19758186   PMID:19786067   PMID:19841163   PMID:19861156   PMID:19923225   PMID:19995952  
PMID:19995959   PMID:20007584   PMID:20100929   PMID:20107166   PMID:20107183   PMID:20124105   PMID:20164430   PMID:20167870   PMID:20233880   PMID:20360967   PMID:20363878   PMID:20435932  
PMID:20451253   PMID:20505141   PMID:20554966   PMID:20562862   PMID:20566717   PMID:20585036   PMID:20628601   PMID:20661430   PMID:20668698   PMID:20692254   PMID:20713712   PMID:20804821  
PMID:20865117   PMID:20937844   PMID:20941330   PMID:20947170   PMID:20956347   PMID:20957750   PMID:20971743   PMID:20974982   PMID:20975040   PMID:21092943   PMID:21106850   PMID:21148557  
PMID:21164516   PMID:21220319   PMID:21242525   PMID:21266579   PMID:21267068   PMID:21317384   PMID:21383019   PMID:21403398   PMID:21462209   PMID:21478252   PMID:21493895   PMID:21515789  
PMID:21525388   PMID:21538349   PMID:21567398   PMID:21637773   PMID:21723157   PMID:21768525   PMID:21849499   PMID:21873635   PMID:21918198   PMID:21988875   PMID:22001348   PMID:22006569  
PMID:22013485   PMID:22031950   PMID:22046349   PMID:22048772   PMID:22072781   PMID:22114338   PMID:22123964   PMID:22124111   PMID:22147891   PMID:22184724   PMID:22189096   PMID:22260507  
PMID:22262694   PMID:22278742   PMID:22308357   PMID:22310660   PMID:22323545   PMID:22361747   PMID:22421267   PMID:22426207   PMID:22454496   PMID:22479513   PMID:22491246   PMID:22496659  
PMID:22541070   PMID:22565312   PMID:22570612   PMID:22572822   PMID:22573805   PMID:22607770   PMID:22634614   PMID:22659029   PMID:22666391   PMID:22689946   PMID:22772463   PMID:22795895  
PMID:22821982   PMID:22837383   PMID:22865861   PMID:22986631   PMID:23019335   PMID:23042151   PMID:23123736   PMID:23142781   PMID:23151845   PMID:23209319   PMID:23209324   PMID:23255589  
PMID:23267850   PMID:23271706   PMID:23290562   PMID:23290966   PMID:23325805   PMID:23349877   PMID:23408632   PMID:23417039   PMID:23463005   PMID:23479606   PMID:23567548   PMID:23585677  
PMID:23610400   PMID:23670194   PMID:23673618   PMID:23676255   PMID:23748743   PMID:23761632   PMID:23762449   PMID:23795287   PMID:23820901   PMID:23843525   PMID:23844087   PMID:23850521  
PMID:23960190   PMID:23986602   PMID:24019532   PMID:24036040   PMID:24038087   PMID:24058413   PMID:24070541   PMID:24091496   PMID:24102120   PMID:24114535   PMID:24140513   PMID:24285719  
PMID:24338782   PMID:24353176   PMID:24362933   PMID:24390148   PMID:24391503   PMID:24409099   PMID:24416163   PMID:24462705   PMID:24486326   PMID:24524192   PMID:24526685   PMID:24572365  
PMID:24598055   PMID:24637670   PMID:24698267   PMID:24729619   PMID:24736450   PMID:24752295   PMID:24783958   PMID:24801628   PMID:24827856   PMID:24878639   PMID:24889626   PMID:24914679  
PMID:24920846   PMID:25008929   PMID:25050810   PMID:25079212   PMID:25101306   PMID:25104770   PMID:25106857   PMID:25118157   PMID:25152077   PMID:25181416   PMID:25188232   PMID:25229251  
PMID:25253340   PMID:25260755   PMID:25264029   PMID:25305318   PMID:25326752   PMID:25378393   PMID:25422874   PMID:25452586   PMID:25539593   PMID:25564448   PMID:25633775   PMID:25681338  
PMID:25692975   PMID:25736436   PMID:25756897   PMID:25780039   PMID:25828701   PMID:25897174   PMID:25911242   PMID:25918231   PMID:25937283   PMID:25964372   PMID:26015500   PMID:26030851  
PMID:26040668   PMID:26076314   PMID:26101320   PMID:26159724   PMID:26253200   PMID:26255864   PMID:26292317   PMID:26350376   PMID:26363072   PMID:26385519   PMID:26392463   PMID:26470915  
PMID:26494305   PMID:26508631   PMID:26508745   PMID:26579632   PMID:26581984   PMID:26595890   PMID:26603638   PMID:26633895   PMID:26676850   PMID:26793623   PMID:26831104   PMID:26855029  
PMID:26885867   PMID:26911613   PMID:26934179   PMID:27046485   PMID:27084119   PMID:27226571   PMID:27328989   PMID:27405980   PMID:27459510   PMID:27477784   PMID:27505671   PMID:27509078  
PMID:27542117   PMID:27560112   PMID:27586271   PMID:27593513   PMID:27606421   PMID:27643721   PMID:27716849   PMID:27727398   PMID:27771719   PMID:27793594   PMID:27810922   PMID:27830702  
PMID:27911948   PMID:27916941   PMID:27979975   PMID:28049762   PMID:28111081   PMID:28166388   PMID:28198368   PMID:28273893   PMID:28300057   PMID:28400473   PMID:28410990   PMID:28411188  
PMID:28416600   PMID:28464285   PMID:28479599   PMID:28495119   PMID:28504245   PMID:28564605   PMID:28607148   PMID:28612840   PMID:28662082   PMID:28768728   PMID:28774595   PMID:28807557  
PMID:28894449   PMID:28945004   PMID:28970238   PMID:29041928   PMID:29330412   PMID:29358670   PMID:29410095   PMID:29438518   PMID:29465830   PMID:29520027   PMID:29555782   PMID:29571298  
PMID:29576482   PMID:29624589   PMID:29632368   PMID:29676038   PMID:29768176   PMID:29777026   PMID:29798841   PMID:29879406   PMID:30177045   PMID:30201994   PMID:30209176   PMID:30209397  
PMID:30246036   PMID:30248373   PMID:30337928   PMID:30364002   PMID:30404733   PMID:30442666   PMID:30481825   PMID:30510167   PMID:30550785   PMID:30550930   PMID:30550931   PMID:30563052  
PMID:30571996   PMID:30583980   PMID:30625140   PMID:30635240   PMID:30642981   PMID:30670552   PMID:30683700   PMID:30699352   PMID:30758987   PMID:30811246   PMID:30906301   PMID:30923196  
PMID:30989399   PMID:30997942   PMID:31067281   PMID:31076723   PMID:31089414   PMID:31243280   PMID:31277274   PMID:31293597   PMID:31350848   PMID:31388100   PMID:31554802   PMID:31562213  
PMID:31562937   PMID:31619538   PMID:31729371   PMID:31754185   PMID:31801911   PMID:31827178   PMID:31852751   PMID:31865314   PMID:31910261   PMID:32040169   PMID:32133501   PMID:32150572  
PMID:32209688   PMID:32325033   PMID:32398807   PMID:32515732   PMID:32539223   PMID:32604471   PMID:32615412   PMID:32631940   PMID:32730309   PMID:32810576   PMID:32878999   PMID:32999457  
PMID:33109186   PMID:33148715   PMID:33154351   PMID:33203755   PMID:33230847   PMID:33274693   PMID:33432245   PMID:33452626   PMID:33519804   PMID:33521935   PMID:33558485   PMID:33615540  
PMID:33707263   PMID:33965533   PMID:34161582   PMID:34206257   PMID:34211474   PMID:34321999   PMID:34341449   PMID:34395439   PMID:34428519   PMID:34471287   PMID:34526512   PMID:34622466  
PMID:34623736   PMID:34678150   PMID:35011620   PMID:35101442   PMID:35215812   PMID:35277480   PMID:35464475   PMID:35584177   PMID:35584192   PMID:35727742   PMID:35809612   PMID:35838047  
PMID:35912640   PMID:35993771   PMID:36034693   PMID:36343752   PMID:36417858   PMID:36575321   PMID:36654880   PMID:36658478   PMID:36797783   PMID:37013819   PMID:37133342   PMID:37167198  
PMID:37193897   PMID:37407556   PMID:37532523   PMID:37544956   PMID:37704739   PMID:37733587   PMID:37848036   PMID:38127424   PMID:38172683   PMID:38374072   PMID:38490196   PMID:38499210  
PMID:38520880   PMID:38671318   PMID:38744293   PMID:38860860   PMID:38909363   PMID:38994942   PMID:39194407   PMID:39213151   PMID:39459842   PMID:39639064   PMID:39642242   PMID:39853307  
PMID:40816660  


Genomics

Comparative Map Data
Tlr3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39845,848,702 - 45,864,112 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl845,848,702 - 45,864,117 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38845,395,665 - 45,411,075 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl845,395,665 - 45,411,080 (-)Ensemblmm10GRCm38
MGSCv37846,481,019 - 46,495,893 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36846,894,482 - 46,909,356 (-)NCBIMGSCv36mm8
Celera848,083,156 - 48,098,074 (-)NCBICelera
Cytogenetic Map8B1.1NCBI
cM Map825.31NCBI
TLR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384186,069,156 - 186,088,073 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4186,068,911 - 186,088,073 (+)Ensemblhg38GRCh38
GRCh374186,990,310 - 187,009,227 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364187,227,303 - 187,243,246 (+)NCBIBuild 36Build 36hg18NCBI36
Build 344187,365,457 - 187,381,399NCBI
Celera4184,312,848 - 184,328,791 (+)NCBICelera
Cytogenetic Map4q35.1NCBI
HuRef4182,742,451 - 182,758,393 (+)NCBIHuRef
CHM1_14186,966,756 - 186,982,686 (+)NCBICHM1_1
T2T-CHM13v2.04189,409,568 - 189,428,483 (+)NCBIT2T-CHM13v2.0
Tlr3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81653,554,916 - 53,572,321 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1653,555,131 - 53,568,385 (+)EnsemblGRCr8
mRatBN7.21646,821,980 - 46,837,900 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1646,822,039 - 46,836,545 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1652,215,759 - 52,229,258 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01655,592,446 - 55,605,923 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01650,855,155 - 50,868,654 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01650,016,466 - 50,031,011 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1650,016,857 - 50,031,214 (+)Ensemblrn6Rnor6.0
Rnor_5.01649,739,814 - 49,753,968 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41650,112,910 - 50,126,371 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1644,813,138 - 44,826,566 (+)NCBICelera
RGSC_v3.11650,112,984 - 50,126,440 (+)NCBI
Cytogenetic Map16q11NCBI
Tlr3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540322,979,120 - 23,001,467 (-)Ensembl
ChiLan1.0NW_00495540322,977,882 - 23,001,392 (-)NCBIChiLan1.0ChiLan1.0
TLR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23183,809,517 - 183,827,550 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14184,159,046 - 184,176,924 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04178,238,352 - 178,256,264 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14190,446,487 - 190,462,728 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4190,446,487 - 190,462,728 (+)EnsemblpanPan2panpan1.1
TLR3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11644,617,012 - 44,633,591 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1644,550,846 - 44,653,247 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1645,103,720 - 45,132,454 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01646,830,974 - 46,859,705 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1646,831,107 - 46,846,486 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11644,798,956 - 44,827,679 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01645,411,963 - 45,440,690 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01645,543,452 - 45,571,950 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tlr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494334,721,792 - 34,740,517 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365543,369,469 - 3,385,907 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365543,370,766 - 3,388,125 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TLR3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1546,969,006 - 46,979,291 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11546,966,262 - 46,977,774 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21553,839,254 - 53,852,671 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TLR3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17131,991,068 - 132,014,366 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7131,991,029 - 132,016,232 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037112,309,987 - 112,333,459 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tlr3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476916,925,984 - 16,941,196 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476916,925,969 - 16,945,250 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Tlr3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11342,428,925 - 42,441,404 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tlr3
1326 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:629
Count of miRNA genes:261
Interacting mature miRNAs:295
Transcripts:ENSMUST00000034056, ENSMUST00000167106
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301139Lmr10_mleishmaniasis resistance 10 (mouse)Not determined83532109757797633Mouse
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81477316071498244Mouse
11049577Lmr10b_mleishmaniasis resistance 10b (mouse)83532109757797633Mouse
4141437W10q14_mweight 10 weeks QTL 14 (mouse)Not determined3250657271740637Mouse
11049578Lmr10c_mleishmaniasis resistance 10c (mouse)83532109757797633Mouse
11041902Lmr10a_mleishmaniasis resistance 10a (mouse)83532109757797633Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83663015493455280Mouse
4141172W6q9_mweight 6 weeks QTL 9 (mouse)Not determined3250657271740637Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined835109930115563747Mouse
10043990Hbnr12_mHeligmosomoides bakeri nematode resistance 12 (mouse)Not determined83327701651290537Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832506572117965439Mouse
4140966Egq12_mearly growth QTL 12 (mouse)Not determined3250657271740637Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837867154110326632Mouse
10043974Obq30_mobesity QTL 30 (mouse)Not determined82658332260583322Mouse
1301298Pgia4_mproteoglycan induced arthritis 4 (mouse)Not determined81656937350569697Mouse
1300912Daq19_mdirectional asymmetry QTL 19 (mouse)Not determined81550657249506729Mouse
13524525Bodwtq7_mbody wweight QTL 7 (mouse)82824955647027681Mouse
1301936Trigq2_mtriglyceride QTL 2 (mouse)Not determined83429039768290537Mouse
1357811Orq3_movulation rate QTL 3 (mouse)Not determined83250657271740637Mouse
1300603Cd8ts2_mCD8 T cell subset 2 (mouse)Not determined81945501853455150Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)84016229795416226Mouse
1301088Alcw6_malcohol withdrawal 6 (mouse)Not determined81550657249506729Mouse
1301160Eae14_msusceptibility to experimental allergic encephalomyelitis 14 (mouse)Not determined81945501853455150Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84474791478748059Mouse
1301550Fembrs2_mfemur breaking strength 2 (mouse)Not determined81832109752321225Mouse

Markers in Region
AI957183  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38845,396,122 - 45,396,224UniSTSGRCm38
MGSCv37846,481,476 - 46,481,578UniSTSGRCm37
Celera848,083,613 - 48,083,715UniSTS
Cytogenetic Map8B2UniSTS
Cytogenetic Map8A4UniSTS
Whitehead/MRC_RH8539.05UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001357316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001357317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_126166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006509278 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006509279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006509280 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006509281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006509283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC116861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC120003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF355152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF420279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK083977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK087739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK166177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC023850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC099937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY770706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000034056   ⟹   ENSMUSP00000034056
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl845,848,702 - 45,863,656 (-)Ensembl
GRCm38.p6 Ensembl845,395,665 - 45,410,619 (-)Ensembl
Ensembl Acc Id: ENSMUST00000167106   ⟹   ENSMUSP00000126556
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl845,848,821 - 45,863,656 (-)Ensembl
GRCm38.p6 Ensembl845,395,784 - 45,410,619 (-)Ensembl
Ensembl Acc Id: ENSMUST00000209269
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl845,862,857 - 45,864,117 (-)Ensembl
GRCm38.p6 Ensembl845,409,820 - 45,411,080 (-)Ensembl
Ensembl Acc Id: ENSMUST00000209651   ⟹   ENSMUSP00000147961
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl845,856,157 - 45,863,595 (-)Ensembl
GRCm38.p6 Ensembl845,403,120 - 45,410,558 (-)Ensembl
Ensembl Acc Id: ENSMUST00000209772   ⟹   ENSMUSP00000147738
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl845,848,915 - 45,863,417 (-)Ensembl
GRCm38.p6 Ensembl845,395,878 - 45,410,380 (-)Ensembl
Ensembl Acc Id: ENSMUST00000210013   ⟹   ENSMUSP00000147783
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl845,848,907 - 45,851,323 (-)Ensembl
GRCm38.p6 Ensembl845,395,870 - 45,398,286 (-)Ensembl
Ensembl Acc Id: ENSMUST00000210354
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl845,862,881 - 45,863,414 (-)Ensembl
GRCm38.p6 Ensembl845,409,844 - 45,410,377 (-)Ensembl
Ensembl Acc Id: ENSMUST00000210996   ⟹   ENSMUSP00000148263
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl845,856,133 - 45,863,413 (-)Ensembl
GRCm38.p6 Ensembl845,403,096 - 45,410,376 (-)Ensembl
Ensembl Acc Id: ENSMUST00000211370   ⟹   ENSMUSP00000148127
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl845,855,900 - 45,863,655 (-)Ensembl
GRCm38.p6 Ensembl845,402,863 - 45,410,618 (-)Ensembl
RefSeq Acc Id: NM_001357316   ⟹   NP_001344245
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39845,848,702 - 45,863,417 (-)NCBI
GRCm38845,395,665 - 45,410,380 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001357317   ⟹   NP_001344246
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39845,848,702 - 45,863,656 (-)NCBI
GRCm38845,395,665 - 45,410,619 (-)NCBI
Sequence:
RefSeq Acc Id: NM_126166   ⟹   NP_569054
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39845,848,702 - 45,863,656 (-)NCBI
GRCm38845,395,665 - 45,410,619 (-)NCBI
MGSCv37846,481,019 - 46,495,893 (-)RGD
Celera848,083,156 - 48,098,074 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006509278   ⟹   XP_006509341
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39845,848,807 - 45,863,473 (-)NCBI
GRCm38845,395,770 - 45,410,443 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006509279   ⟹   XP_006509342
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39845,848,807 - 45,864,112 (-)NCBI
GRCm38845,395,770 - 45,411,075 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006509280   ⟹   XP_006509343
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39845,848,807 - 45,863,882 (-)NCBI
GRCm38845,395,770 - 45,410,851 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006509281   ⟹   XP_006509344
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39845,848,807 - 45,863,473 (-)NCBI
GRCm38845,395,770 - 45,410,443 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006509283   ⟹   XP_006509346
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39845,848,807 - 45,863,473 (-)NCBI
GRCm38845,395,770 - 45,410,443 (-)NCBI
Sequence:
RefSeq Acc Id: NP_569054   ⟸   NM_126166
- Peptide Label: precursor
- UniProtKB: Q91ZM4 (UniProtKB/Swiss-Prot),   Q99MB1 (UniProtKB/Swiss-Prot),   Q499F3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006509342   ⟸   XM_006509279
- Peptide Label: isoform X1
- UniProtKB: Q91ZM4 (UniProtKB/Swiss-Prot),   Q99MB1 (UniProtKB/Swiss-Prot),   Q499F3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006509343   ⟸   XM_006509280
- Peptide Label: isoform X1
- UniProtKB: Q91ZM4 (UniProtKB/Swiss-Prot),   Q99MB1 (UniProtKB/Swiss-Prot),   Q499F3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006509344   ⟸   XM_006509281
- Peptide Label: isoform X1
- UniProtKB: Q91ZM4 (UniProtKB/Swiss-Prot),   Q99MB1 (UniProtKB/Swiss-Prot),   Q499F3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006509346   ⟸   XM_006509283
- Peptide Label: isoform X1
- UniProtKB: Q91ZM4 (UniProtKB/Swiss-Prot),   Q99MB1 (UniProtKB/Swiss-Prot),   Q499F3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006509341   ⟸   XM_006509278
- Peptide Label: isoform X1
- UniProtKB: Q91ZM4 (UniProtKB/Swiss-Prot),   Q99MB1 (UniProtKB/Swiss-Prot),   Q499F3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001344246   ⟸   NM_001357317
- Peptide Label: precursor
- UniProtKB: Q99MB1 (UniProtKB/Swiss-Prot),   Q91ZM4 (UniProtKB/Swiss-Prot),   Q499F3 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001344245   ⟸   NM_001357316
- Peptide Label: precursor
- UniProtKB: Q99MB1 (UniProtKB/Swiss-Prot),   Q91ZM4 (UniProtKB/Swiss-Prot),   Q499F3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000034056   ⟸   ENSMUST00000034056
Ensembl Acc Id: ENSMUSP00000148127   ⟸   ENSMUST00000211370
Ensembl Acc Id: ENSMUSP00000148263   ⟸   ENSMUST00000210996
Ensembl Acc Id: ENSMUSP00000147783   ⟸   ENSMUST00000210013
Ensembl Acc Id: ENSMUSP00000126556   ⟸   ENSMUST00000167106
Ensembl Acc Id: ENSMUSP00000147738   ⟸   ENSMUST00000209772
Ensembl Acc Id: ENSMUSP00000147961   ⟸   ENSMUST00000209651
Protein Domains
LRRCT   LRRNT   TIR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99MB1-F1-model_v2 AlphaFold Q99MB1 1-905 view protein structure

Promoters
RGD ID:8666995
Promoter ID:EPDNEW_M11528
Type:initiation region
Name:Tlr3_2
Description:Mus musculus toll-like receptor 3 , transcript variant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M11529  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38845,409,898 - 45,409,958EPDNEW
RGD ID:8666997
Promoter ID:EPDNEW_M11529
Type:initiation region
Name:Tlr3_1
Description:Mus musculus toll-like receptor 3 , transcript variant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M11528  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38845,410,336 - 45,410,396EPDNEW
RGD ID:6849262
Promoter ID:MM_XEF:7043
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_4Hour
Transcripts:NM_198791
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36846,494,926 - 46,495,426 (-)MPROMDB
RGD ID:6843805
Promoter ID:MM_KWN:54300
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_126166,   UC009LOY.1,   UC009LPA.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36846,495,536 - 46,496,036 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2156367 AgrOrtholog
Ensembl Genes ENSMUSG00000031639 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000034056 ENTREZGENE
  ENSMUST00000034056.12 UniProtKB/Swiss-Prot
  ENSMUST00000167106 ENTREZGENE
  ENSMUST00000167106.3 UniProtKB/Swiss-Prot
  ENSMUST00000209772 ENTREZGENE
  ENSMUST00000209772.2 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.10140 UniProtKB/Swiss-Prot
  3.80.10.10 UniProtKB/Swiss-Prot
InterPro Cys-rich_flank_reg_C UniProtKB/Swiss-Prot
  Leu-rich_rpt UniProtKB/Swiss-Prot
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot
  LRR_dom_sf UniProtKB/Swiss-Prot
  TIR_dom UniProtKB/Swiss-Prot
  TLR3_TMD UniProtKB/Swiss-Prot
  Toll_tir_struct_dom_sf UniProtKB/Swiss-Prot
KEGG Report mmu:142980 UniProtKB/Swiss-Prot
MGD MGI:2156367 ENTREZGENE
NCBI Gene 142980 ENTREZGENE
PANTHER PTHR24365 UniProtKB/Swiss-Prot
  PTHR24365:SF524 UniProtKB/Swiss-Prot
Pfam LRR_1 UniProtKB/Swiss-Prot
  LRR_8 UniProtKB/Swiss-Prot
  TIR UniProtKB/Swiss-Prot
  Tlr3_TMD UniProtKB/Swiss-Prot
PhenoGen Tlr3 PhenoGen
PRINTS LEURICHRPT UniProtKB/Swiss-Prot
PROSITE LRR UniProtKB/Swiss-Prot
  TIR UniProtKB/Swiss-Prot
SMART LRR_SD22 UniProtKB/Swiss-Prot
  LRR_TYP UniProtKB/Swiss-Prot
  LRRCT UniProtKB/Swiss-Prot
  TIR UniProtKB/Swiss-Prot
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot
  SSF52200 UniProtKB/Swiss-Prot
UniProt A0A1B0GS40_MOUSE UniProtKB/TrEMBL
  A0A1B0GSY9_MOUSE UniProtKB/TrEMBL
  A0A1B0GTA2_MOUSE UniProtKB/TrEMBL
  A0A1Y7VI41_MOUSE UniProtKB/TrEMBL
  Q3TM31_MOUSE UniProtKB/TrEMBL
  Q499F3 ENTREZGENE, UniProtKB/TrEMBL
  Q8C2X8_MOUSE UniProtKB/TrEMBL
  Q91ZM4 ENTREZGENE
  Q99MB1 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q91ZM4 UniProtKB/Swiss-Prot