Cdkn2a (cyclin dependent kinase inhibitor 2A) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Cdkn2a (cyclin dependent kinase inhibitor 2A) Mus musculus
Symbol: Cdkn2a
Name: cyclin dependent kinase inhibitor 2A
RGD ID: 10322
Description: Exhibits MDM2/MDM4 family protein binding activity; enzyme inhibitor activity; and protein N-terminus binding activity. Involved in several processes, including negative regulation of cell population proliferation; negative regulation of cellular protein metabolic process; and positive regulation of apoptotic process. Localizes to cytoplasm; granular component; and protein-containing complex. Predicted to colocalize with nuclear body. Is expressed in several structures, including bone marrow; central nervous system; dorsal root ganglion; eye; and testis. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); carcinoma (multiple); hematologic cancer (multiple); melanoma (multiple); and nervous system cancer (multiple). Orthologous to human CDKN2A (cyclin dependent kinase inhibitor 2A); PARTICIPATES IN altered G1/S transition pathway; G1/S transition pathway; pancreatic cancer pathway; INTERACTS WITH (S)-nicotine; 1,2-dichloroethane; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A; alternative reading frame; Arf; ARF-; ARF-INK4a; CDK4I; cyclin-dependent kinase 4 inhibitor A; cyclin-dependent kinase inhibitor 2A; cyclin-dependent kinase inhibitor 2A (p16, inhibits CDK4); cyclin-dependent kinase inhibitor 2A, isoform 3; cyclin-dependent kinase inhibitor 2A, isoforms 1/2; cyclin-dependent kinase inhibitor protein; INK4; INK4a-ARF; Ink4a/Arf; mitochondrial smARF; MTS; MTS1; p1; p16; p16(INK4a); p16-INK4; p16-INK4a; p16I; p16INK4a; p19; p19; p19ARF; Pct; Pctr1
RGD Orthologs
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39489,192,710 - 89,212,856 (-)NCBIGRCm39mm39
GRCm38489,274,473 - 89,294,619 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl489,274,471 - 89,294,653 (-)EnsemblGRCm38mm10GRCm38
MGSCv37488,920,377 - 88,940,523 (-)NCBIGRCm37mm9NCBIm37
MGSCv36488,745,868 - 88,765,796 (-)NCBImm8
Celera487,760,902 - 87,780,610 (-)NCBICelera
Cytogenetic Map4C4NCBI
cM Map442.15NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
adenocarcinoma  (ISO)
Adrenal Gland Neoplasms  (ISO)
adrenocortical carcinoma  (ISO)
adult hepatocellular carcinoma  (ISO)
B-lymphoblastic leukemia/lymphoma  (IMP,ISO)
bladder urothelial carcinoma  (ISO)
bone disease  (ISO)
Brain Neoplasms  (ISO)
Brain Stem Neoplasms  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Carcinogenesis  (ISO)
cervix uteri carcinoma in situ  (ISO)
cholangiocarcinoma  (ISO)
Chromosome Deletion  (ISO)
chronic myeloid leukemia  (ISO)
Colonic Neoplasms  (ISO)
Colorectal Neoplasms  (ISO)
cutaneous T cell lymphoma  (ISO)
diffuse large B-cell lymphoma  (ISO)
disease of cellular proliferation  (ISO)
dysplastic nevus syndrome  (ISO)
endometrial cancer  (ISO)
Endometrial Neoplasms  (ISO)
esophageal carcinoma  (ISO)
Esophageal Neoplasms  (ISO)
esophagus adenocarcinoma  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Arthritis  (ISO)
Experimental Leukemia  (IMP)
familial melanoma  (ISO)
Fluoride Poisoning  (ISO)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
Genetic Translocation  (ISO)
Germ Cell and Embryonal Neoplasms  (ISO)
germinoma  (ISO)
glaucoma  (ISO)
glioblastoma  (ISO)
granulosa cell tumor  (ISO)
head and neck squamous cell carcinoma  (ISO)
hepatocellular carcinoma  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
high grade glioma  (ISO)
Hyperplasia  (ISO)
hypertension  (ISO)
in situ carcinoma  (ISO)
invasive ductal carcinoma  (ISO)
Kidney Neoplasms  (ISO)
leiomyosarcoma  (ISO)
leukemia  (ISO)
liver cancer  (ISO)
Liver Neoplasms  (ISO)
lung adenocarcinoma  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
lymphoma  (ISO)
Mammary Neoplasms, Experimental  (IAGP,ISO)
melanoma  (IMP,ISO)
melanoma and neural system tumor syndrome  (ISO)
Melanoma-Pancreatic Cancer Syndrome  (ISO)
Mesothelioma  (ISO)
Micronuclei, Chromosome-Defective  (ISO)
Mouth Neoplasms  (ISO)
multiple myeloma  (ISO)
myelodysplastic syndrome  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
nephroblastoma  (ISO)
Nerve Sheath Neoplasms  (ISO)
neurilemmoma  (ISO)
neuroblastoma  (ISO)
obesity  (ISO)
osteoarthritis  (ISO)
osteosarcoma  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic adenocarcinoma  (ISO)
pancreatic cancer  (ISO)
pancreatic carcinoma  (ISO)
pancreatic ductal carcinoma  (ISO)
papillary renal cell carcinoma  (ISO)
papillomavirus infectious disease  (ISO)
peripheral nervous system disease  (ISO)
persistent hyperplastic primary vitreous  (IMP)
plasmacytoma  (IMP)
Poisoning  (ISO)
pre-malignant neoplasm  (ISO)
Premature Aging  (IEP)
prostate adenocarcinoma  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (IDA)
renal cell carcinoma  (ISO)
retinoblastoma  (ISO)
rhabdomyosarcoma  (ISO)
sarcomatoid mesothelioma  (ISO)
schizophrenia  (ISO)
Sezary's disease  (ISO)
skin melanoma  (ISO)
Sporadic Papillary Renal Cell Carcinoma  (ISO)
squamous cell carcinoma  (IAGP,ISO)
Stomach Neoplasms  (ISO)
T-cell acute lymphoblastic leukemia  (IDA,IMP,ISO)
T-cell lymphoblastic leukemia/lymphoma  (IMP)
thymoma  (ISO)
Tongue Neoplasms  (ISO)
transient cerebral ischemia  (IEP)
transitional cell carcinoma  (ISO)
Trisomy  (ISO)
urinary bladder cancer  (ISO)
Urogenital Neoplasms  (ISO)
uterine carcinosarcoma  (ISO)
Uterine Cervical Neoplasms  (ISO)
Vulvar Lichen Sclerosus  (ISO)
Vulvar Neoplasms  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (EXP)
(Z)-3-butylidenephthalide  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2-acetamidofluorene  (ISO)
3-chloropropane-1,2-diol  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (ISO)
4-vinylcyclohexene dioxide  (EXP)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-azacytidine  (EXP,ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
amosite asbestos  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
belinostat  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
beryllium atom  (ISO)
beryllium dihydride  (ISO)
beryllium sulfate  (ISO)
beryllium(0)  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
BMS-754807  (ISO)
busulfan  (EXP)
Butylbenzyl phthalate  (EXP)
butyric acid  (EXP)
C60 fullerene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcium dichloride  (ISO)
cannabidiol  (EXP,ISO)
capecitabine  (ISO)
capsaicin  (ISO)
carbon nanotube  (EXP,ISO)
carmustine  (ISO)
casticin  (ISO)
chloramphenicol  (ISO)
chloroethene  (ISO)
chromium atom  (ISO)
chromium(6+)  (EXP,ISO)
cisplatin  (ISO)
clofibric acid  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
corticosterone  (ISO)
crocidolite asbestos  (EXP,ISO)
curcumin  (ISO)
cycloheximide  (ISO)
D-glucose  (ISO)
daunorubicin  (ISO)
dehydroepiandrosterone  (ISO)
Deoxycorticosterone acetate  (ISO)
Diacetoxyscirpenol  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dichloroacetic acid  (EXP)
dichromic acid  (ISO)
dichromium trioxide  (ISO)
diethyl phthalate  (EXP)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dimethylarsinic acid  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
etoposide  (EXP,ISO)
fenbendazole  (ISO)
ferric oxide  (EXP)
fluoxetine  (EXP)
folic acid  (EXP,ISO)
fumonisin B1  (EXP)
furan  (ISO)
gamma-tocopherol  (ISO)
glucaric acid  (EXP)
glucose  (ISO)
glycidol  (ISO)
glycine betaine  (ISO)
glyphosate  (ISO)
GW 3965  (ISO)
harmine  (ISO)
hexachlorobenzene  (ISO)
hydralazine  (ISO)
hydrochlorothiazide  (ISO)
hydrogen peroxide  (ISO)
hydroxyurea  (ISO)
irinotecan  (ISO)
isocyanates  (EXP)
L-ascorbic acid  (ISO)
lead diacetate  (ISO)
lidocaine  (EXP)
linalool  (ISO)
lithium chloride  (ISO)
LY294002  (ISO)
maneb  (ISO)
masoprocol  (ISO)
Mecamylamine  (EXP)
menadione  (ISO)
menaquinone  (ISO)
mercury dibromide  (ISO)
methimazole  (ISO)
methoxyacetic acid  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (EXP,ISO)
methylseleninic acid  (ISO)
microcystin RR  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
monobenzyl phthalate  (EXP)
monoethyl phthalate  (EXP)
monosodium L-glutamate  (EXP,ISO)
myo-inositol hexakisphosphate  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
nickel dichloride  (ISO)
nickel subsulfide  (ISO)
nicotinamide  (EXP)
nicotine  (EXP)
nitrogen dioxide  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (EXP)
p-menthan-3-ol  (ISO)
palbociclib  (EXP,ISO)
paracetamol  (ISO)
paraquat  (ISO)
parathion  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl caffeate  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
potassium dichromate  (ISO)
prednisone  (ISO)
procainamide  (ISO)
promethazine  (ISO)
quercetin  (ISO)
quinoline  (ISO)
radon atom  (ISO)
radon(0)  (ISO)
reserpine  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
salubrinal  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
silver(1+) nitrate  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sodium fluoride  (EXP,ISO)
spironolactone  (ISO)
stavudine  (EXP)
streptozocin  (EXP)
sulforaphane  (EXP)
sulfur dioxide  (ISO)
sulindac  (ISO)
T-2 toxin  (ISO)
terephthalic acid  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
thioridazine  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
urethane  (EXP)
valproic acid  (ISO)
vincristine  (ISO)
vinorelbine  (ISO)
wogonin  (ISO)
zearalenone  (ISO)
zidovudine  (EXP,ISO)
zinc pyrithione  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
aging  (IMP)
amyloid fibril formation  (ISO)
apoptotic mitochondrial changes  (ISO)
apoptotic process  (IEA)
autophagy of mitochondrion  (ISO)
cell aging  (IDA)
cell cycle arrest  (IDA,ISO)
cellular response to glucose stimulus  (ISO)
cellular response to hydrogen peroxide  (IDA)
cellular senescence  (IDA,IMP,ISO)
cerebellum development  (ISO)
epidermis development  (IMP)
G1/S transition of mitotic cell cycle  (ISO)
glucose homeostasis  (IMP)
mitochondrial depolarization  (ISO)
negative regulation of B cell proliferation  (IMP)
negative regulation of cell cycle  (IDA)
negative regulation of cell growth  (IMP,ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cell-matrix adhesion  (ISO)
negative regulation of cyclin-dependent protein serine/threonine kinase activity  (IDA,ISO)
negative regulation of hepatocyte proliferation  (ISO)
negative regulation of immature T cell proliferation in thymus  (IMP)
negative regulation of mammary gland epithelial cell proliferation  (IMP)
negative regulation of NF-kappaB transcription factor activity  (ISO)
negative regulation of phosphorylation  (ISO)
negative regulation of protein binding  (IDA)
negative regulation of protein kinase activity  (ISO)
negative regulation of protein neddylation  (ISO)
negative regulation of proteolysis involved in cellular protein catabolic process  (IDA,ISO)
negative regulation of transcription, DNA-templated  (ISO)
negative regulation of ubiquitin protein ligase activity  (ISO)
negative regulation of ubiquitin-dependent protein catabolic process  (IDA,ISO)
negative regulation of ubiquitin-protein transferase activity  (IDA)
neurogenesis  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of apoptotic process involved in mammary gland involution  (IMP)
positive regulation of cell cycle arrest  (ISO)
positive regulation of cellular senescence  (ISO)
positive regulation of DNA damage response, signal transduction by p53 class mediator  (IC,ISO)
positive regulation of DNA-binding transcription factor activity  (IMP)
positive regulation of gene expression  (ISO)
positive regulation of macrophage apoptotic process  (IGI)
positive regulation of protein localization to nucleus  (ISO)
positive regulation of protein sumoylation  (ISO)
positive regulation of signal transduction by p53 class mediator  (ISO)
positive regulation of smooth muscle cell apoptotic process  (IGI)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (IMP,ISO)
protein destabilization  (ISO)
protein K63-linked ubiquitination  (ISO)
protein polyubiquitination  (ISO)
protein stabilization  (ISO)
Ras protein signal transduction  (ISO)
regulation of apoptotic DNA fragmentation  (ISO)
regulation of cyclin-dependent protein serine/threonine kinase activity  (IDA)
regulation of DNA-binding transcription factor activity  (IGI)
regulation of G2/M transition of mitotic cell cycle  (ISO)
regulation of gene expression  (IMP)
regulation of nucleocytoplasmic transport  (IGI)
regulation of protein export from nucleus  (ISO)
regulation of protein stability  (IMP)
regulation of protein targeting to mitochondrion  (ISO)
replicative senescence  (ISO)
response to caloric restriction  (ISO)
response to drug  (ISO)
response to fatty acid  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to organonitrogen compound  (ISO)
response to salt stress  (ISO)
rRNA processing  (IEA)
rRNA transcription  (IGI)
senescence-associated heterochromatin focus assembly  (ISO)
somatic stem cell division  (IMP)
somatic stem cell population maintenance  (IGI)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal branching of the mammary ductal tree  (IAGP)
abnormal cell cycle  (IAGP)
abnormal cell physiology  (IAGP)
abnormal common myeloid progenitor cell morphology  (IAGP)
abnormal eye morphology  (IAGP)
abnormal forebrain development  (IAGP)
abnormal intestine morphology  (IAGP)
abnormal keratinocyte physiology  (IAGP)
abnormal lens capsule morphology  (IAGP)
abnormal lens development  (IAGP)
abnormal lens morphology  (IAGP)
abnormal male germ cell apoptosis  (IAGP)
abnormal mammary gland duct morphology  (IAGP)
abnormal melanocyte morphology  (IAGP)
abnormal melanocyte proliferation  (IAGP)
abnormal meninges morphology  (IAGP)
abnormal metabolism  (IAGP)
abnormal mitosis  (IAGP)
abnormal myogenesis  (IAGP)
abnormal nervous system morphology  (IAGP)
abnormal pancreas development  (IAGP)
abnormal pluripotent precursor cell morphology  (IAGP)
abnormal posterior eye segment morphology  (IAGP)
abnormal prostate gland morphology  (IAGP)
abnormal retina morphology  (IAGP)
abnormal retinal ganglion layer morphology  (IAGP)
abnormal retinal inner nuclear layer morphology  (IAGP)
abnormal retinal neuronal layer morphology  (IAGP)
abnormal retinal photoreceptor morphology  (IAGP)
abnormal skin development  (IAGP)
abnormal skin physiology  (IAGP)
abnormal somite development  (IAGP)
abnormal sperm number  (IAGP)
abnormal spermatocyte morphology  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal spleen red pulp morphology  (IAGP)
abnormal telomere length  (IAGP)
abnormal tumor incidence  (IAGP)
abnormal vitreous body morphology  (IAGP)
ascites  (IAGP)
binocular blindness  (IAGP)
blindness  (IAGP)
cachexia  (IAGP)
cataract  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased cell proliferation  (IAGP)
decreased incidence of tumors by chemical induction  (IAGP)
decreased testis weight  (IAGP)
decreased thymocyte number  (IAGP)
decreased tumor growth/size  (IAGP)
decreased tumor incidence  (IAGP)
decreased tumor latency  (IAGP)
delayed cellular replicative senescence  (IAGP)
distended abdomen  (IAGP)
embryonic growth arrest  (IAGP)
enhanced wound healing  (IAGP)
enlarged liver  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
epidermal hyperplasia  (IAGP)
extramedullary hematopoiesis  (IAGP)
hindlimb paralysis  (IAGP)
hunched posture  (IAGP)
hydrocephaly  (IAGP)
hyperkeratosis  (IAGP)
hyperpigmentation  (IAGP)
increased acute lymphoblastic leukemia incidence  (IAGP)
increased adenocarcinoma incidence  (IAGP)
increased B cell derived lymphoma incidence  (IAGP)
increased brain tumor incidence  (IAGP)
increased carcinoma incidence  (IAGP)
increased CD4-positive, alpha beta T cell number  (IAGP)
increased CD8-positive, alpha-beta T cell number  (IAGP)
increased cell proliferation  (IAGP)
increased cellular sensitivity to ionizing radiation  (IAGP)
increased classified tumor incidence  (IAGP)
increased cutaneous melanoma incidence  (IAGP)
increased double-positive T cell number  (IAGP)
increased fibroblast proliferation  (IAGP)
increased fibrohistocytoma incidence  (IAGP)
increased fibrosarcoma incidence  (IAGP)
increased gastrointestinal stromal tumor incidence  (IAGP)
increased glioblastoma incidence  (IAGP)
increased glioma incidence  (IAGP)
increased hemangiosarcoma incidence  (IAGP)
increased histiocytic sarcoma incidence  (IAGP)
increased incidence of tumors by chemical induction  (IAGP)
increased incidence of tumors by ionizing radiation induction  (IAGP)
increased incidence of tumors by UV-induction  (IAGP)
increased intestinal adenoma incidence  (IAGP)
increased intraocular melanoma incidence  (IAGP)
increased keratinocyte migration  (IAGP)
increased keratinocyte proliferation  (IAGP)
increased leukemia incidence  (IAGP)
increased liver tumor incidence  (IAGP)
increased lung adenocarcinoma incidence  (IAGP)
increased lung carcinoma incidence  (IAGP)
increased lung tumor incidence  (IAGP)
increased lymphoma incidence  (IAGP)
increased malignant tumor incidence  (IAGP)
increased melanoma incidence  (IAGP)
increased meningioma incidence  (IAGP)
increased mesothelioma incidence  (IAGP)
increased metastatic potential  (IAGP)
increased neurofibrosarcoma incidence  (IAGP)
increased neuron apoptosis  (IAGP)
increased oligodendroglioma incidence  (IAGP)
increased osteoma incidence  (IAGP)
increased osteosarcoma incidence  (IAGP)
increased pancreas adenoma incidence  (IAGP)
increased pancreas tumor incidence  (IAGP)
increased pancreatic ductal adenocarcinoma incidence  (IAGP)
increased pancreatic intraepithelial neoplasia incidence  (IAGP)
increased papilloma incidence  (IAGP)
increased prostate gland adenocarcinoma incidence  (IAGP)
increased rhabdomyosarcoma incidence  (IAGP)
increased sarcoma incidence  (IAGP)
increased satellite cell number  (IAGP)
increased Schwannoma incidence  (IAGP)
increased skin squamous cell carcinoma incidence  (IAGP)
increased skin tumor incidence  (IAGP)
increased small lymphocytic lymphoma incidence  (IAGP)
increased spindle cell carcinoma incidence  (IAGP)
increased spleen white pulp amount  (IAGP)
increased splenocyte proliferation  (IAGP)
increased squamous cell carcinoma incidence  (IAGP)
increased stomach tumor incidence  (IAGP)
increased T cell derived lymphoma incidence  (IAGP)
increased testis weight  (IAGP)
increased thymus weight  (IAGP)
increased tumor growth/size  (IAGP)
increased tumor incidence  (IAGP)
increased uterus leiomyoma incidence  (IAGP)
intestinal fibrosis  (IAGP)
jaundice  (IAGP)
kyphosis  (IAGP)
lung hemorrhage  (IAGP)
male infertility  (IAGP)
mammary gland duct hyperplasia  (IAGP)
microphthalmia  (IAGP)
oligozoospermia  (IAGP)
osseous metaplasia  (IAGP)
pancreas cysts  (IAGP)
paralysis  (IAGP)
persistent hyperplastic primary vitreous  (IAGP)
pleural effusion  (IAGP)
premature aging  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IAGP)
primary vitreous hyperplasia  (IAGP)
retinal detachment  (IAGP)
seizures  (IAGP)
skeletal muscle hyperplasia  (IAGP)
skeletal muscle interstitial fibrosis  (IAGP)
skin fibrosis  (IAGP)
skin lesions  (IAGP)
testicular atrophy  (IAGP)
thymus hyperplasia  (IAGP)
weight loss  (IAGP)

References - curated