Nt5c (5',3'-nucleotidase, cytosolic) - Rat Genome Database
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Gene: Nt5c (5',3'-nucleotidase, cytosolic) Mus musculus
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Symbol: Nt5c
Name: 5',3'-nucleotidase, cytosolic
RGD ID: 1556950
MGI Page MGI
Description: Exhibits 5'-nucleotidase activity. Involved in deoxyribonucleotide catabolic process. Localizes to mitochondrion. Orthologous to human NT5C (5', 3'-nucleotidase, cytosolic); PARTICIPATES IN gemcitabine pharmacodynamics pathway; gemcitabine pharmacokinetics pathway; lamivudine pharmacokinetics pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 5' nucleotidase, deoxy (pyrimidine), cytosolic type C; 5'(3')-deoxyribonucleotidase, cytosolic type; cytosolic 5',3'-pyrimidine nucleotidase; deoxy-5'-nucleotidase 1; Dn; Dnt; dNT-1; Dnt1; Umph; Umph-; Umph-2; Umph2; uridine monophosphatase 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911115,381,246 - 115,382,896 (-)NCBIGRCm39mm39
GRCm3811115,490,420 - 115,492,070 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11115,490,420 - 115,491,862 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711115,351,739 - 115,353,128 (-)NCBIGRCm37mm9NCBIm37
MGSCv3611115,306,515 - 115,307,904 (-)NCBImm8
Celera11127,257,296 - 127,258,685 (-)NCBICelera
Cytogenetic Map11E2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
cytosol  (ISO)
mitochondrion  (HDA)
nucleus  (ISO)

References

Additional References at PubMed
PMID:2776480   PMID:3034234   PMID:3116273   PMID:6301357   PMID:7894159   PMID:7958795   PMID:8889548   PMID:10349636   PMID:10681516   PMID:10922068   PMID:11042159   PMID:11076861  
PMID:12477932   PMID:14610273   PMID:14681479   PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073   PMID:18614015   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22277657  


Genomics

Comparative Map Data
Nt5c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911115,381,246 - 115,382,896 (-)NCBIGRCm39mm39
GRCm3811115,490,420 - 115,492,070 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11115,490,420 - 115,491,862 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711115,351,739 - 115,353,128 (-)NCBIGRCm37mm9NCBIm37
MGSCv3611115,306,515 - 115,307,904 (-)NCBImm8
Celera11127,257,296 - 127,258,685 (-)NCBICelera
Cytogenetic Map11E2NCBI
NT5C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1775,130,225 - 75,131,757 (-)EnsemblGRCh38hg38GRCh38
GRCh381775,130,228 - 75,131,965 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371773,126,320 - 73,127,890 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361770,637,918 - 70,639,472 (-)NCBINCBI36hg18NCBI36
Build 341770,637,918 - 70,639,472NCBI
Celera1769,718,700 - 69,720,253 (-)NCBI
Cytogenetic Map17q25.1NCBI
HuRef1768,536,008 - 68,537,577 (-)NCBIHuRef
CHM1_11773,190,820 - 73,192,389 (-)NCBICHM1_1
Nt5c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.010104,052,807 - 104,054,805 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10104,052,831 - 104,054,805 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010104,225,988 - 104,227,164 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410105,574,754 - 105,576,848 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1099,314,518 - 99,316,243 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
Nt5c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555532,011,738 - 2,013,443 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555532,011,549 - 2,014,209 (-)NCBIChiLan1.0ChiLan1.0
NT5C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11774,632,846 - 74,634,136 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01769,077,021 - 69,078,998 (-)NCBIMhudiblu_PPA_v0panPan3
NT5C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl95,343,378 - 5,344,380 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.195,342,793 - 5,344,432 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Nt5c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936594430,274 - 432,027 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NT5C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl126,139,439 - 6,164,142 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1126,162,420 - 6,164,143 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2126,124,412 - 6,126,605 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NT5C
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11646,531,820 - 46,533,763 (+)NCBI
ChlSab1.1 Ensembl1646,532,216 - 46,535,736 (+)Ensembl
Nt5c
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248014,952,736 - 4,954,660 (-)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357859Lvrq7_mliver weight QTL 7 (mouse)Not determined1112318637118131898Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112318637118131898Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181683655115683810Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181683655115683810Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181919441115919441Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182486872116486994Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185954085119954085Mouse
15039374Adip29_madiposity 29 (mouse)1186717494120717494Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186717494120717494Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186717494120717494Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187600000126900000Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187611774121611872Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189978425122082543Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191713782122082543Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191713782122082543Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193338357122082543Mouse
4141939Pregq2_mpregnancy QTL 2 (mouse)Not determined1194172953118131898Mouse
27226731Tibmd4_mtibia midshaft diameter 4, 10 week (mouse)1194300000119000000Mouse
4141465Dbm2_mdiabetes modifier 2 (mouse)Not determined94546357118131898Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195513139122082543Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195513139122082543Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196246848122082543Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196919310122082543Mouse
1301983Berr2_mberghei resistance locus 2 (mouse)Not determined1198461783122082543Mouse
10043976Obq33_mobesity QTL 33 (mouse)Not determined1198609643122082543Mouse
10044001Alcw8_malcohol withdrawal 8 (mouse)Not determined1199363361122082543Mouse
11553867Stmm5_mskin tumor modifier of MSM 5 (mouse)11100167277122082543Mouse
11341721Rvfs2_mRift Valley fever susceptibility 2 (mouse)11100363360120996339Mouse
1301012Vispl_mvisual placing (mouse)Not determined11101131764122082543Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1001
Count of miRNA genes:384
Interacting mature miRNAs:425
Transcripts:ENSMUST00000021082, ENSMUST00000106530, ENSMUST00000124778, ENSMUST00000125940, ENSMUST00000130668
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000021082   ⟹   ENSMUSP00000021082
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl11115,490,420 - 115,491,862 (-)Ensembl
RefSeq Acc Id: ENSMUST00000106530   ⟹   ENSMUSP00000102140
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl11115,490,420 - 115,491,815 (-)Ensembl
RefSeq Acc Id: ENSMUST00000124778
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl11115,490,638 - 115,491,851 (-)Ensembl
RefSeq Acc Id: ENSMUST00000125940
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl11115,490,700 - 115,491,202 (-)Ensembl
RefSeq Acc Id: ENSMUST00000130668
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl11115,490,771 - 115,491,371 (-)Ensembl
RefSeq Acc Id: NM_015807   ⟹   NP_056622
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911115,381,251 - 115,382,640 (-)NCBI
GRCm3811115,490,425 - 115,491,814 (-)NCBI
MGSCv3711115,351,739 - 115,353,128 (-)RGD
Celera11127,257,296 - 127,258,685 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011249123   ⟹   XP_011247425
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911115,381,246 - 115,382,697 (-)NCBI
GRCm3811115,490,420 - 115,491,874 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003949472
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911115,381,251 - 115,382,896 (-)NCBI
GRCm3811115,490,420 - 115,492,070 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_056622   ⟸   NM_015807
- UniProtKB: Q9JM14 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011247425   ⟸   XM_011249123
- Peptide Label: isoform X1
- UniProtKB: A2A9X5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000102140   ⟸   ENSMUST00000106530
RefSeq Acc Id: ENSMUSP00000021082   ⟸   ENSMUST00000021082

Promoters
RGD ID:6821465
Promoter ID:MM_KWN:10533
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000106530,   OTTMUST00000007263,   OTTMUST00000007264,   OTTMUST00000007266,   OTTMUST00000007267
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611115,352,331 - 115,353,327 (-)MPROMDB
RGD ID:8677352
Promoter ID:EPDNEW_M16707
Type:initiation region
Name:Nt5c_1
Description:Mus musculus 5',3'-nucleotidase, cytosolic , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3811115,491,824 - 115,491,884EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1354954 AgrOrtholog
Ensembl Genes ENSMUSG00000020736 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000021082 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000102140 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000021082 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000106530 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1000 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 5'(3')-deoxyribonucleotidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HAD-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HAD_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:50773 UniProtKB/Swiss-Prot
MGD MGI:1354954 ENTREZGENE
NCBI Gene 50773 ENTREZGENE
Pfam NT5C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nt5c PhenoGen
Superfamily-SCOP SSF56784 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2A9X5 ENTREZGENE, UniProtKB/TrEMBL
  NT5C_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE