Cd274 (CD274 antigen) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Cd274 (CD274 antigen) Mus musculus
Analyze
Symbol: Cd274
Name: CD274 antigen
RGD ID: 1553554
MGI Page MGI
Description: Is expressed in retina and thymus primordium. Orthologous to human CD274 (CD274 molecule).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: A530045L16Rik; B7 homolog 1; B7h1; PD-; PDCD1 ligand 1; Pdcd1l; Pdcd1l1; Pdcd1lg1; Pdl1; programmed cell death 1 ligand 1; programmed death ligand 1; RIKEN cDNA A530045L16 gene
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391929,339,428 - 29,365,495 (+)NCBIGRCm39mm39
GRCm39 Ensembl1929,344,855 - 29,365,495 (+)Ensembl
GRCm381929,362,107 - 29,388,095 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1929,367,455 - 29,388,095 (+)EnsemblGRCm38mm10GRCm38
MGSCv371929,441,928 - 29,462,585 (+)NCBIGRCm37mm9NCBIm37
MGSCv361929,433,452 - 29,454,092 (+)NCBImm8
Celera1930,144,050 - 30,164,685 (+)NCBICelera
Cytogenetic Map19C1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute myocarditis  (IEP)
adult T-cell leukemia  (ISO)
allergic disease  (ISO)
alveolar echinococcosis  (IMP)
anti-basement membrane glomerulonephritis  (IMP)
asthma  (IMP)
autoimmune hepatitis  (IEP)
cervix uteri carcinoma in situ  (ISO)
Chlamydia pneumonia  (IEP)
Chronic Hepatitis B  (IMP,ISO)
Chronic Hepatitis C  (ISO)
colon cancer  (IMP)
Corneal Graft Rejection  (ISO)
Coxsackievirus Infections  (IDA)
cryptococcal meningitis  (ISO)
cutaneous leishmaniasis  (IMP)
Disease Progression  (ISO)
Fungemia  (IMP)
Hepatic Echinococcosis  (IEP)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
herpes simplex  (IMP)
herpes simplex virus keratitis  (IMP)
histoplasmosis  (IEP)
human immunodeficiency virus infectious disease  (ISO)
influenza  (ISO)
Lung Neoplasms  (ISO)
lymphocytic choriomeningitis  (IMP)
lymphoma  (ISO)
Mammary Neoplasms, Experimental  (ISO)
nasal type extranodal NK/T-cell lymphoma  (ISO)
Neoplasm Metastasis  (ISO)
Neoplasms, Radiation-Induced  (ISO)
ovarian cancer  (IMP)
papillomavirus infectious disease  (ISO)
periodontitis  (ISO)
pre-eclampsia  (ISO)
primary progressive multiple sclerosis  (IMP)
pulmonary tuberculosis  (ISO)
rabies  (IMP)
Recurrence  (ISO)
Recurrent Respiratory Papillomatosis  (ISO)
respiratory syncytial virus infectious disease  (IEP,IMP)
Retroviridae Infections  (IMP)
Sepsis  (ISO)
Spinal Cord Injuries  (ISO)
stomach cancer  (ISO)
substance-related disorder  (ISO)
Thymus Neoplasms  (ISO)
toxic shock syndrome  (ISO)
Transplant Rejection  (IMP)
tuberculosis  (ISO)
Viral Bronchiolitis  (IEP,IMP)
viral encephalitis  (IEP,IMP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,2-dimethylhydrazine  (EXP)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2-hydroxypropanoic acid  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
5-fluorouracil  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
aripiprazole  (ISO)
benzalkonium chloride  (EXP)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (ISO)
bromobenzene  (ISO)
buta-1,3-diene  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
calcitriol  (ISO)
cannabidiol  (EXP)
carbon nanotube  (EXP)
carboplatin  (ISO)
chloroquine  (ISO)
chlorpromazine  (ISO)
cisplatin  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (EXP)
dextran sulfate  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
estriol  (EXP)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
eugenol  (ISO)
ferric oxide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (ISO)
imiquimod  (EXP)
isoeugenol  (ISO)
kojic acid  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (EXP,ISO)
LY294002  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (EXP)
pentanal  (ISO)
phenformin  (ISO)
phenobarbital  (EXP)
platycodin D  (ISO)
protein kinase inhibitor  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (ISO)
succimer  (EXP)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
thyroxine  (ISO)
titanium dioxide  (EXP)
trans-isoeugenol  (ISO)
trichostatin A  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
vincristine  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function
protein binding  (IPI,ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal CD4-positive, alpha beta T cell morphology  (IAGP)
abnormal CD8-positive, alpha beta T cell morphology  (IAGP)
abnormal CD8-positive, alpha-beta T cell physiology  (IAGP)
abnormal chemokine secretion  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal dendritic cell physiology  (IAGP)
abnormal immune system physiology  (IEA)
abnormal interleukin secretion  (IAGP)
abnormal regulatory T cell physiology  (IAGP)
abnormal T cell activation  (IAGP)
abnormal T cell morphology  (IAGP)
abnormal T follicular helper cell physiology  (IAGP)
abnormal T-helper 1 cell differentiation  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased germinal center B cell number  (IAGP)
decreased IgG1 level  (IAGP)
decreased IgG2a level  (IAGP)
decreased interleukin-17 secretion  (IAGP)
decreased interleukin-4 secretion  (IAGP)
decreased plasma cell number  (IAGP)
decreased susceptibility to parasitic infection  (IAGP)
decreased susceptibility to Riboviria infection  (IAGP)
decreased susceptibility to Riboviria infection induced morbidity/mortality  (IAGP)
decreased T cell apoptosis  (IAGP)
decreased T helper 1 cell number  (IAGP)
decreased T-helper 17 cell number  (IAGP)
hyperresponsive to tactile stimuli  (IAGP)
increased activated T cell number  (IAGP)
increased CD8-positive, alpha-beta T cell number  (IAGP)
increased IgG1 level  (IAGP)
increased IgG2c level  (IAGP)
increased interferon-gamma secretion  (IAGP)
increased interleukin-2 secretion  (IAGP)
increased interleukin-4 secretion  (IAGP)
increased susceptibility to autoimmune diabetes  (IAGP)
increased susceptibility to autoimmune disorder  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased susceptibility to bacterial infection induced morbidity/mortality  (IAGP)
increased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
increased susceptibility to induced arthritis  (IAGP)
increased susceptibility to injury  (IAGP)
increased T cell number  (IAGP)
increased T cell proliferation  (IAGP)
increased tumor necrosis factor secretion  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
References

References - curated
1. null
2. Abiko K, etal., Clin Cancer Res. 2013 Mar 15;19(6):1363-74. doi: 10.1158/1078-0432.CCR-12-2199. Epub 2013 Jan 22.
3. Cao J, etal., Chin Med J (Engl). 2009 Aug 20;122(16):1941-6.
4. Chang KC, etal., Crit Care. 2013 May 11;17(3):R85. doi: 10.1186/cc12711.
5. Che YM, etal., J Cell Biochem. 2018 Apr;119(4):3044-3057. doi: 10.1002/jcb.26432. Epub 2017 Dec 26.
6. Correa-Rocha R, etal., PLoS One. 2018 Aug 30;13(8):e0203419. doi: 10.1371/journal.pone.0203419. eCollection 2018.
7. Duncan DS and Miller SD, PLoS One. 2011 Apr 8;6(4):e18548.
8. Erickson JJ, etal., J Clin Invest. 2012 Aug;122(8):2967-82. doi: 10.1172/JCI62860. Epub 2012 Jul 17.
9. Feng C, etal., Viral Immunol. 2015 Oct;28(8):418-24. doi: 10.1089/vim.2015.0062. Epub 2015 Aug 12.
10. Frebel H, etal., J Exp Med. 2012 Dec 17;209(13):2485-99. doi: 10.1084/jem.20121015. Epub 2012 Dec 10.
11. Han X, etal., J Cancer Res Clin Oncol. 2019 Feb;145(2):303-312. doi: 10.1007/s00432-018-2758-6. Epub 2018 Sep 28.
12. Hatam LJ, etal., Clin Cancer Res. 2012 Apr 1;18(7):1925-35. doi: 10.1158/1078-0432.CCR-11-2941. Epub 2012 Feb 9.
13. He H, etal., J Neurotrauma. 2018 Nov 1;35(21):2591-2603. doi: 10.1089/neu.2017.5625. Epub 2018 Jun 7.
14. Ito S, etal., Oncology. 2020;98(7):501-511. doi: 10.1159/000506075. Epub 2020 May 7.
15. Jeon S, etal., J Immunol. 2018 Jun 1;200(11):3711-3719. doi: 10.4049/jimmunol.1700417. Epub 2018 Apr 18.
16. Jeong HY, etal., J Leukoc Biol. 2008 Mar;83(3):755-64. doi: 10.1189/jlb.0307168. Epub 2007 Dec 17.
17. Jonas BA, Sci Transl Med. 2017 Apr 19;9(386). pii: 9/386/eaan2781. doi: 10.1126/scitranslmed.aan2781.
18. Jun H, etal., FEBS Lett. 2005 Nov 7;579(27):6259-64. doi: 10.1016/j.febslet.2005.09.098. Epub 2005 Oct 19.
19. Kim WY, etal., Virchows Arch. 2016 Nov;469(5):581-590. doi: 10.1007/s00428-016-2011-0. Epub 2016 Sep 5.
20. La X, etal., Int Immunopharmacol. 2015 Jun;26(2):357-66. doi: 10.1016/j.intimp.2015.04.013. Epub 2015 Apr 20.
21. Lafon M, etal., J Immunol. 2008 Jun 1;180(11):7506-15. doi: 10.4049/jimmunol.180.11.7506.
22. Lee I, etal., J Immunol. 2003 Dec 15;171(12):6929-35.
23. León-Flores A, etal., Immunol Lett. 2018 Nov;203:70-79. doi: 10.1016/j.imlet.2018.09.007. Epub 2018 Sep 17.
24. Liang SC, etal., Eur J Immunol. 2006 Jan;36(1):58-64. doi: 10.1002/eji.200535458.
25. Liu X, etal., Pathol Res Pract. 2020 Apr;216(4):152881. doi: 10.1016/j.prp.2020.152881. Epub 2020 Feb 13.
26. Lázár-Molnár E, etal., Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2658-63. doi: 10.1073/pnas.0711918105. Epub 2008 Feb 11.
27. McNab FW, etal., Eur J Immunol. 2011 Jul;41(7):1941-7. doi: 10.1002/eji.201141421. Epub 2011 May 27.
28. MGD data from the GO Consortium
29. MGD IEA
30. Miyoshi H, etal., Blood. 2016 Sep 8;128(10):1374-81. doi: 10.1182/blood-2016-02-698936. Epub 2016 Jul 14.
31. Nosov M, etal., Am J Transplant. 2012 May;12(5):1313-22. doi: 10.1111/j.1600-6143.2011.03948.x. Epub 2012 Feb 2.
32. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
33. Pan T, etal., Mediators Inflamm. 2015;2015:539841. doi: 10.1155/2015/539841. Epub 2015 Apr 30.
34. Phares TW, etal., J Immunol. 2010 Nov 1;185(9):5607-18. Epub 2010 Sep 27.
35. Reynolds J, etal., Nephrol Dial Transplant. 2012 Apr;27(4):1343-50. doi: 10.1093/ndt/gfr529. Epub 2011 Sep 29.
36. RGD automated import pipeline for gene-chemical interactions
37. Shao R, etal., Crit Care. 2016 May 9;20(1):124. doi: 10.1186/s13054-016-1301-x.
38. Shen T, etal., J Med Virol. 2010 Jul;82(7):1152-9. doi: 10.1002/jmv.21809.
39. Shwetank, etal., Front Immunol. 2019 Apr 17;10:783. doi: 10.3389/fimmu.2019.00783. eCollection 2019.
40. Singh A, etal., J Infect Dis. 2013 Aug 15;208(4):603-15. doi: 10.1093/infdis/jit206. Epub 2013 May 9.
41. Starkey MR, etal., Am J Respir Cell Mol Biol. 2016 Apr;54(4):493-503. doi: 10.1165/rcmb.2015-0204OC.
42. Tian M, etal., Sci Rep. 2016 Jun 9;6:27683. doi: 10.1038/srep27683.
43. Valero-Pacheco N, etal., Clin Dev Immunol. 2013;2013:989673. doi: 10.1155/2013/989673. Epub 2013 Sep 26.
44. Wang J, etal., Parasite Immunol. 2018 Dec;40(12):e12596. doi: 10.1111/pim.12596. Epub 2018 Nov 4.
45. Wang T, etal., Antiviral Res. 2019 Jun;166:1-10. doi: 10.1016/j.antiviral.2019.03.007. Epub 2019 Mar 20.
46. Weng ZH, etal., Zhonghua Gan Zang Bing Za Zhi. 2010 Apr;18(4):263-6. doi: 10.3760/cma.j.issn.1007-3418.2010.04.007.
47. Wilson JK, etal., Crit Care. 2018 Apr 17;22(1):95. doi: 10.1186/s13054-018-2020-2.
48. Xia Q, etal., Mediators Inflamm. 2018 Nov 22;2018:1632902. doi: 10.1155/2018/1632902. eCollection 2018.
49. Xue M, etal., Nutr Cancer. 2017 Nov-Dec;69(8):1234-1244. doi: 10.1080/01635581.2017.1362446. Epub 2017 Oct 18.
50. Yang W, etal., Immunology. 2013 Aug;139(4):513-22. doi: 10.1111/imm.12101.
51. Yang X, etal., Shanghai Kou Qiang Yi Xue. 2019 Dec;28(6):591-596.
52. Yao S, etal., Mucosal Immunol. 2015 Jul;8(4):746-59. doi: 10.1038/mi.2014.106. Epub 2014 Dec 3.
53. Zeng Z, etal., PLoS One. 2011;6(9):e23621. doi: 10.1371/journal.pone.0023621. Epub 2011 Sep 1.
54. Zhao Y, etal., Shock. 2019 Mar;51(3):289-297. doi: 10.1097/SHK.0000000000001171.
Additional References at PubMed
PMID:10349636   PMID:11015443   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11224527   PMID:11238124   PMID:11500834   PMID:11857337   PMID:11932780   PMID:12161284   PMID:12218188  
PMID:12421930   PMID:12444166   PMID:12477932   PMID:12719480   PMID:14515261   PMID:14724428   PMID:14991067   PMID:15030776   PMID:15191948   PMID:15240716   PMID:15249675   PMID:15489334  
PMID:15565659   PMID:15568026   PMID:15758163   PMID:15827960   PMID:15905503   PMID:16027236   PMID:16034097   PMID:16141072   PMID:16141073   PMID:16236366   PMID:16251499   PMID:16301644  
PMID:16382236   PMID:16517716   PMID:16602821   PMID:16606670   PMID:16917960   PMID:16951320   PMID:17016562   PMID:17056517   PMID:17116737   PMID:17142723   PMID:17182110   PMID:17289811  
PMID:17339272   PMID:17392506   PMID:17412283   PMID:17606978   PMID:17627890   PMID:17629517   PMID:17667813   PMID:17785803   PMID:17825988   PMID:17853943   PMID:17899549   PMID:17911591  
PMID:17911605   PMID:17911606   PMID:17924994   PMID:17938288   PMID:17975322   PMID:17975811   PMID:18005363   PMID:18025191   PMID:18097035   PMID:18163954   PMID:18212277   PMID:18223165  
PMID:18354207   PMID:18354211   PMID:18420489   PMID:18421793   PMID:18490756   PMID:18577709   PMID:18593946   PMID:18607390   PMID:18621049   PMID:18641123   PMID:18684942   PMID:18809920  
PMID:18813109   PMID:18825752   PMID:18981087   PMID:19075244   PMID:19160960   PMID:19164599   PMID:19201863   PMID:19202065   PMID:19234172   PMID:19234176   PMID:19339692   PMID:19342693  
PMID:19380790   PMID:19417208   PMID:19420345   PMID:19424967   PMID:19497561   PMID:19535153   PMID:19535643   PMID:19553531   PMID:19602708   PMID:19710456   PMID:19724910   PMID:19741598  
PMID:19757438   PMID:19783989   PMID:19890047   PMID:19949087   PMID:19955307   PMID:20007574   PMID:20008522   PMID:20019373   PMID:20051242   PMID:20194714   PMID:20215643   PMID:20375308  
PMID:20381020   PMID:20453843   PMID:20472828   PMID:20484136   PMID:20498261   PMID:20506224   PMID:20520738   PMID:20551512   PMID:20574047   PMID:20639491   PMID:20639904   PMID:20653631  
PMID:20686128   PMID:20739617   PMID:20802088   PMID:21047981   PMID:21061440   PMID:21063028   PMID:21118528   PMID:21131428   PMID:21159661   PMID:21172867   PMID:21263067   PMID:21307196  
PMID:21357717   PMID:21393583   PMID:21401869   PMID:21435468   PMID:21481304   PMID:21490158   PMID:21498129   PMID:21503939   PMID:21525357   PMID:21525385   PMID:21576466   PMID:21677750  
PMID:21697455   PMID:21697456   PMID:21730022   PMID:21742975   PMID:21768399   PMID:21768400   PMID:21792877   PMID:21813777   PMID:21873635   PMID:21884581   PMID:22025548   PMID:22156590  
PMID:22157630   PMID:22168579   PMID:22179405   PMID:22231652   PMID:22247470   PMID:22381170   PMID:22508931   PMID:22614805   PMID:22699081   PMID:22726954   PMID:22798683   PMID:22808056  
PMID:22906740   PMID:22962681   PMID:22993390   PMID:23028899   PMID:23237504   PMID:23409193   PMID:23417675   PMID:23444404   PMID:23533995   PMID:23545706   PMID:23555047   PMID:23593203  
PMID:23656736   PMID:23716698   PMID:23766529   PMID:23966393   PMID:23970300   PMID:23977133   PMID:23986400   PMID:23995234   PMID:24015822   PMID:24021877   PMID:24030385   PMID:24031027  
PMID:24040397   PMID:24065812   PMID:24067957   PMID:24078774   PMID:24215864   PMID:24324295   PMID:24353266   PMID:24379123   PMID:24382348   PMID:24391505   PMID:24496394   PMID:24529703  
PMID:24606770   PMID:24639353   PMID:24696476   PMID:24778419   PMID:24794706   PMID:24848257   PMID:24890099   PMID:24978830   PMID:25027060   PMID:25047812   PMID:25053811   PMID:25057927  
PMID:25070848   PMID:25144375   PMID:25173046   PMID:25299080   PMID:25332429   PMID:25348003   PMID:25404361   PMID:25445618   PMID:25479230   PMID:25488990   PMID:25609381   PMID:25624454  
PMID:25877928   PMID:25889536   PMID:25902191   PMID:25924065   PMID:25934860   PMID:25964334   PMID:26043977   PMID:26105028   PMID:26214513   PMID:26247556   PMID:26266810   PMID:26378076  
PMID:26484769   PMID:26599163   PMID:26601142   PMID:26755818   PMID:26775640   PMID:26824266   PMID:26847035   PMID:26895637   PMID:26990974   PMID:27294527   PMID:27295261   PMID:27371844  
PMID:27378243   PMID:27396388   PMID:27463676   PMID:27533014   PMID:27556047   PMID:27671636   PMID:27731324   PMID:27809306   PMID:27824138   PMID:27835902   PMID:27911948   PMID:27935862  
PMID:27966604   PMID:28079159   PMID:28220772   PMID:28254435   PMID:28302645   PMID:28414296   PMID:28414328   PMID:28423181   PMID:28427861   PMID:28436428   PMID:28530662   PMID:28570665  
PMID:28665401   PMID:28687491   PMID:28736328   PMID:28744199   PMID:28747424   PMID:28768724   PMID:28777458   PMID:28819064   PMID:28848055   PMID:28912267   PMID:28917991   PMID:28935898  
PMID:28953925   PMID:28974543   PMID:29018057   PMID:29028305   PMID:29246442   PMID:29250533   PMID:29272267   PMID:29282253   PMID:29337303   PMID:29337305   PMID:29377881   PMID:29480817  
PMID:29493401   PMID:29504948   PMID:29531164   PMID:29568117   PMID:29602773   PMID:29617057   PMID:29665734   PMID:29735482   PMID:29752314   PMID:29765039   PMID:29776963   PMID:29793310  
PMID:29844327   PMID:29867974   PMID:29995830   PMID:30012633   PMID:30045970   PMID:30076099   PMID:30089911   PMID:30095976   PMID:30213644   PMID:30315115   PMID:30341238   PMID:30357491  
PMID:30382149   PMID:30385408   PMID:30456891   PMID:30567732   PMID:30619369   PMID:30709740   PMID:30763282   PMID:30765734   PMID:30791745   PMID:30804928   PMID:30850589   PMID:30873585  
PMID:30927016   PMID:30975083   PMID:30978356   PMID:31000591   PMID:31037153   PMID:31180054   PMID:31197205   PMID:31305264   PMID:31379842   PMID:31482256   PMID:31503548   PMID:31604033  
PMID:31656199   PMID:31729316   PMID:31865052   PMID:31907984   PMID:31994912   PMID:32048861   PMID:32198140   PMID:32347357   PMID:32520957   PMID:32527950   PMID:32610128   PMID:32623477  
PMID:32632663   PMID:32633234   PMID:32641478   PMID:32698011   PMID:32973173   PMID:33229527  


Genomics

Comparative Map Data
Cd274
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391929,339,428 - 29,365,495 (+)NCBIGRCm39mm39
GRCm39 Ensembl1929,344,855 - 29,365,495 (+)Ensembl
GRCm381929,362,107 - 29,388,095 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1929,367,455 - 29,388,095 (+)EnsemblGRCm38mm10GRCm38
MGSCv371929,441,928 - 29,462,585 (+)NCBIGRCm37mm9NCBIm37
MGSCv361929,433,452 - 29,454,092 (+)NCBImm8
Celera1930,144,050 - 30,164,685 (+)NCBICelera
Cytogenetic Map19C1NCBI
CD274
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl95,450,503 - 5,470,566 (+)EnsemblGRCh38hg38GRCh38
GRCh3895,450,542 - 5,470,554 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3795,450,542 - 5,470,554 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3695,440,559 - 5,458,477 (+)NCBINCBI36hg18NCBI36
Celera95,376,139 - 5,396,204 (+)NCBI
Cytogenetic Map9p24.1NCBI
HuRef95,406,210 - 5,426,274 (+)NCBIHuRef
CHM1_195,450,664 - 5,470,759 (+)NCBICHM1_1
Cd274
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21227,116,627 - 227,137,379 (+)NCBI
Rnor_6.0 Ensembl1247,519,939 - 247,537,943 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01247,519,890 - 247,539,659 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01254,768,528 - 254,788,292 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41233,053,607 - 233,065,384 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1224,273,306 - 224,285,083 (+)NCBICelera
Cytogenetic Map1q52NCBI
Cd274
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554349,487,315 - 9,505,904 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554349,487,309 - 9,508,366 (+)NCBIChiLan1.0ChiLan1.0
CD274
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.195,454,391 - 5,474,452 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl95,454,391 - 5,474,402 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v095,269,270 - 5,289,629 (+)NCBIMhudiblu_PPA_v0panPan3
CD274
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl193,585,518 - 93,603,522 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1193,461,735 - 93,605,772 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Cd274
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936539132,870 - 145,288 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CD274
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1216,660,047 - 216,792,724 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11216,646,378 - 216,792,731 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21242,395,402 - 242,416,220 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CD274
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11274,038,844 - 74,060,662 (-)NCBI
ChlSab1.1 Ensembl1274,041,767 - 74,056,806 (-)Ensembl
Cd274
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247369,991,851 - 10,017,047 (+)NCBI

Position Markers
Cd274  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19C2UniSTS
cM Map19 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301271Datd_mdopamine transporter density (mouse)Not determined19132362870Mouse
4142406Pbctlp1_mperipheral blood cytotoxic T lymphocyte percentage 1 (mouse)Not determined132897810Mouse
1300904Chab5_mcholesterol absorption 5 (mouse)Not determined19167640035676563Mouse
26884385Skwq14_mskull length QTL 14, 16 week (mouse)19320000035900000Mouse
1300923Bits4_mbitterness sensitivity 4 (mouse)Not determined19334585237345984Mouse
1301800Faq10_mfluctuating asymmetry QTL 10 (mouse)Not determined19334585237345984Mouse
1300591Pas3_mpulmonary adenoma susceptibility 3 (mouse)Not determined19334585237345984Mouse
1302126Skull26_mskull morphology 26 (mouse)Not determined19334585237345984Mouse
11039522Tbbr4_mTrypanosoma brucei brucei response 4 (mouse)19533596239336106Mouse
1301228Iba4_minduction of brown adipocytes 4 (mouse)Not determined19932831543328421Mouse
1302019Pgia23_mproteoglycan induced arthritis 23 (mouse)Not determined19981005343810202Mouse
14928311Manh85_mmandible shape 85 (mouse)191193738945937389Mouse
10413881Moe2_mmodifier of epilepsy 2 (mouse)191494561648945738Mouse
1301336Alcp23_malcohol preference locus 23 (mouse)Not determined191593520749935319Mouse
1301633Alcp24_malcohol preference locus 24 (mouse)Not determined191593520749935319Mouse
1302004Lfp2_mlong free running period 2 (mouse)Not determined191831776252317981Mouse
1302063Eae19_mexperimental allergic encephalomyelitis 19 (mouse)Not determined191831776252317981Mouse
4142343Moen2_mmodifier of engrailed QTL 2 (mouse)Not determined192025691554257062Mouse
10412251Mnp_mmodifier of Niemann Pick type C1 (mouse)Not determined192025691554257062Mouse
4141659Pbwg20_mpostnatal body weight growth 20 (mouse)Not determined192139025755390480Mouse
1357596Tgct3_mtesticular germ cell tumor 3 (mouse)Not determined192200672732935319Mouse
1558876W3q14_mweight 3 weeks QTL 14 (mouse)Not determined192233596253923073Mouse
12790634Ebm1_mEpidermolysis Bullosa modifier 1 (mouse)192500000059000000Mouse
1302123Tlsr8_mthymic lymphoma suppressor region 8 (mouse)Not determined192515863842400477Mouse
1301451Ath16_matherosclerosis 16 (mouse)Not determined192543847859438566Mouse
13506250Renmq1_mrenal mercury accumulation QTL 1 (mouse)192739715561397266Mouse
1357568Tgct4_mtesticular germ cell tumor 4 (mouse)Not determined192779458535317981Mouse
4141138Femwf11_mfemur work to failure 11 (mouse)Not determined2815190961431566Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:891
Count of miRNA genes:526
Interacting mature miRNAs:637
Transcripts:ENSMUST00000016640
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000016640   ⟹   ENSMUSP00000016640
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1929,367,455 - 29,388,095 (+)Ensembl
RefSeq Acc Id: NM_021893   ⟹   NP_068693
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391929,344,838 - 29,365,495 (+)NCBI
GRCm381929,367,438 - 29,388,095 (+)ENTREZGENE
MGSCv371929,441,928 - 29,462,585 (+)RGD
Celera1930,144,050 - 30,164,685 (+)RGD
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030251020   ⟹   XP_030106880
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391929,339,428 - 29,365,495 (+)NCBI
GRCm381929,362,107 - 29,388,095 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030251021   ⟹   XP_030106881
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391929,344,845 - 29,365,495 (+)NCBI
GRCm381929,367,413 - 29,388,095 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_068693   ⟸   NM_021893
- Peptide Label: precursor
- UniProtKB: Q9EP73 (UniProtKB/Swiss-Prot),   Q3U472 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030106880   ⟸   XM_030251020
- Peptide Label: isoform X1
RefSeq Acc Id: XP_030106881   ⟸   XM_030251021
- Peptide Label: isoform X2
RefSeq Acc Id: ENSMUSP00000016640   ⟸   ENSMUST00000016640
Protein Domains
Ig-like   Ig-like C2-type   Ig-like V-type

Promoters
RGD ID:13679216
Promoter ID:EPDNEW_M23758
Type:initiation region
Name:Cd274_1
Description:Mus musculus CD274 antigen , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381929,367,460 - 29,367,520EPDNEW
RGD ID:6829735
Promoter ID:MM_KWN:26794
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Liver,   Lung,   Spleen
Transcripts:OTTMUST00000035406,   OTTMUST00000082381,   OTTMUST00000082382
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361929,441,446 - 29,442,047 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1926446 AgrOrtholog
Ensembl Genes ENSMUSG00000016496 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000016640 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000016640 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CD80_C2-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:60533 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1926446 ENTREZGENE
NCBI Gene 60533 ENTREZGENE
Pfam C2-set_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cd274 PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt PD1L1_MOUSE UniProtKB/Swiss-Prot
  Q3U472 ENTREZGENE, UniProtKB/TrEMBL
  Q9EP73 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-02 Cd274  CD274 antigen  A530045L16Rik  RIKEN cDNA A530045L16 gene  Data Merged 737654 PROVISIONAL