Rragb (Ras-related GTP binding B) - Rat Genome Database

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Gene: Rragb (Ras-related GTP binding B) Mus musculus
Analyze
Symbol: Rragb
Name: Ras-related GTP binding B
RGD ID: 1614123
MGI Page MGI
Description: Predicted to enable GTP binding activity; GTPase activity; and GTPase binding activity. Predicted to be involved in several processes, including cellular response to leucine starvation; negative regulation of autophagy; and positive regulation of TORC1 signaling. Predicted to be located in cytoplasm. Predicted to be part of Gtr1-Gtr2 GTPase complex. Predicted to be active in lysosome and nucleus. Orthologous to human RRAGB (Ras related GTP binding B).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC69750; MGC95567; rag B; ragB; ras-related GTP-binding protein B
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X151,920,640 - 151,973,188 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX151,922,977 - 151,954,939 (+)EnsemblGRCm39 Ensembl
GRCm38X153,137,644 - 153,190,192 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX153,139,981 - 153,171,943 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X149,574,501 - 149,606,486 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X148,480,716 - 148,512,659 (+)NCBIMGSCv36mm8
CeleraX136,082,622 - 136,114,670 (-)NCBICelera
Cytogenetic MapXF3NCBI
cM MapX68.46NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
Gtr1-Gtr2 GTPase complex  (IBA)
lysosome  (IBA,ISO)
membrane  (IEA)
nucleus  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Regulation of mTORC1 by amino acids. Bar-Peled L and Sabatini DM, Trends Cell Biol. 2014 Jul;24(7):400-6. doi: 10.1016/j.tcb.2014.03.003. Epub 2014 Mar 31.
2. Molecular mechanisms of mTOR-mediated translational control. Ma XM and Blenis J, Nat Rev Mol Cell Biol. 2009 May;10(5):307-18. Epub 2009 Apr 2.
3. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12466851   PMID:12477932   PMID:14660641   PMID:15489334   PMID:21267068   PMID:21873635   PMID:24768164   PMID:24980141   PMID:25567907   PMID:30595499   PMID:31649036   PMID:32554809  
PMID:33373332   PMID:37380769  


Genomics

Comparative Map Data
Rragb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X151,920,640 - 151,973,188 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX151,922,977 - 151,954,939 (+)EnsemblGRCm39 Ensembl
GRCm38X153,137,644 - 153,190,192 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX153,139,981 - 153,171,943 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X149,574,501 - 149,606,486 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X148,480,716 - 148,512,659 (+)NCBIMGSCv36mm8
CeleraX136,082,622 - 136,114,670 (-)NCBICelera
Cytogenetic MapXF3NCBI
cM MapX68.46NCBI
RRAGB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X55,717,749 - 55,758,774 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX55,717,749 - 55,758,774 (+)EnsemblGRCh38hg38GRCh38
GRCh37X55,744,182 - 55,785,207 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X55,760,904 - 55,801,932 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X55,627,199 - 55,668,227NCBI
CeleraX59,582,631 - 59,623,721 (+)NCBICelera
Cytogenetic MapXp11.21NCBI
HuRefX52,797,429 - 52,838,892 (+)NCBIHuRef
CHM1_1X55,734,228 - 55,775,318 (+)NCBICHM1_1
T2T-CHM13v2.0X55,010,926 - 55,051,952 (+)NCBIT2T-CHM13v2.0
RragB
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X21,560,313 - 21,610,550 (-)NCBIGRCr8
mRatBN7.2X18,184,619 - 18,234,639 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX18,184,992 - 18,234,639 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX15,603,770 - 15,635,471 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X24,489,470 - 24,521,171 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X18,664,290 - 18,695,991 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X19,085,913 - 19,135,049 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX19,336,372 - 19,369,746 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 EnsemblX19,101,522 - 19,134,869 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X20,103,258 - 20,136,624 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X38,352,967 - 38,384,643 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X38,406,474 - 38,438,064 (-)NCBI
CeleraX18,476,842 - 18,508,518 (-)NCBICelera
Cytogenetic MapXq12NCBI
Rragb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554752,662,868 - 2,696,364 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554752,662,969 - 2,692,253 (+)NCBIChiLan1.0ChiLan1.0
RRAGB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X57,173,092 - 57,211,949 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X57,176,828 - 57,216,049 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X48,003,566 - 48,042,285 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X56,155,662 - 56,194,335 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX56,155,662 - 56,194,335 (+)Ensemblpanpan1.1panPan2
RRAGB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X47,323,427 - 47,361,551 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX47,323,269 - 47,361,138 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX38,516,639 - 38,554,727 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X47,577,861 - 47,616,565 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX47,577,665 - 47,616,152 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X46,816,268 - 46,854,351 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X47,554,657 - 47,592,735 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X47,476,313 - 47,514,405 (+)NCBIUU_Cfam_GSD_1.0
Rragb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X40,046,042 - 40,078,894 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936819955,527 - 988,644 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936819946,874 - 988,531 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RRAGB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX48,286,592 - 48,330,195 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X48,286,584 - 48,330,196 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X54,154,898 - 54,165,886 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RRAGB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X51,806,561 - 51,848,263 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX51,806,596 - 51,848,502 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660865,877,647 - 5,919,125 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rragb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624910727,034 - 760,671 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624910726,467 - 760,293 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rragb
947 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:257
Count of miRNA genes:193
Interacting mature miRNAs:218
Transcripts:ENSMUST00000039720, ENSMUST00000144175
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357823Spha3_msperm head anomaly 3 (mouse)Not determinedX102055848162758941Mouse
1301209Cia19_mcollagen induced arthritis 19 (mouse)Not determinedX120993165160213038Mouse
25314309Syncl5_msynaptonemal complex length 5 (mouse)X121909697152582996Mouse
10412164Cmv2_mcytomegalovirus resistance 2 (mouse)Not determinedX125685149159685269Mouse
13824981Svwq2_mseminal vesicle weight QTL 2 (mouse)X128900749153782996Mouse
1558900Bw3_mbody weight QTL 3 (mouse)Not determinedX133540040165298595Mouse
10401118Pgia39_mproteoglycan induced arthritis 39 (mouse)Not determinedX144474380169476592Mouse
1302000Pgia25_mproteoglycan induced arthritis 2 (mouse)Not determinedX144474380169476592Mouse
12738421Lfibq17_mliver fibrosis QTL 17 (mouse)X148148453164945064Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000039720   ⟹   ENSMUSP00000039013
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX151,922,977 - 151,954,939 (+)Ensembl
GRCm38.p6 EnsemblX153,139,981 - 153,171,943 (+)Ensembl
RefSeq Acc Id: ENSMUST00000144175   ⟹   ENSMUSP00000134162
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX151,922,983 - 151,936,183 (+)Ensembl
GRCm38.p6 EnsemblX153,139,987 - 153,153,187 (+)Ensembl
RefSeq Acc Id: NM_001004154   ⟹   NP_001004154
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X151,922,954 - 151,954,939 (+)NCBI
GRCm38X153,139,958 - 153,171,943 (+)NCBI
MGSCv37X149,574,501 - 149,606,486 (+)RGD
CeleraX136,082,622 - 136,114,670 (-)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006528849   ⟹   XP_006528912
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X151,920,640 - 151,954,939 (+)NCBI
GRCm38X153,137,644 - 153,171,853 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006528850   ⟹   XP_006528913
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X151,920,640 - 151,973,188 (+)NCBI
GRCm38X153,137,644 - 153,190,192 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006528851   ⟹   XP_006528914
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X151,920,640 - 151,954,939 (+)NCBI
GRCm38X153,137,644 - 153,171,943 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017318502   ⟹   XP_017173991
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X151,920,640 - 151,942,397 (+)NCBI
GRCm38X153,137,644 - 153,159,401 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030251348   ⟹   XP_030107208
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X151,920,640 - 151,954,939 (+)NCBI
GRCm38X153,137,644 - 153,171,943 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036161969   ⟹   XP_036017862
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X151,920,640 - 151,973,188 (+)NCBI
Sequence:
RefSeq Acc Id: XR_004940337
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X151,920,640 - 151,954,939 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001004154   ⟸   NM_001004154
- UniProtKB: B1AVD6 (UniProtKB/Swiss-Prot),   Q6NTA4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006528913   ⟸   XM_006528850
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006528914   ⟸   XM_006528851
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006528912   ⟸   XM_006528849
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017173991   ⟸   XM_017318502
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_030107208   ⟸   XM_030251348
- Peptide Label: isoform X5
RefSeq Acc Id: ENSMUSP00000134162   ⟸   ENSMUST00000144175
RefSeq Acc Id: ENSMUSP00000039013   ⟸   ENSMUST00000039720
RefSeq Acc Id: XP_036017862   ⟸   XM_036161969
- Peptide Label: isoform X4

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6NTA4-F1-model_v2 AlphaFold Q6NTA4 1-374 view protein structure

Promoters
RGD ID:6846339
Promoter ID:MM_KWN:62425
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B6
Transcripts:OTTMUST00000046164,   OTTMUST00000046165,   UC009UQT.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X149,574,466 - 149,574,997 (+)MPROMDB
RGD ID:13681674
Promoter ID:EPDNEW_M24986
Type:initiation region
Name:Rragb_1
Description:Mus musculus Ras-related GTP binding B , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X153,139,973 - 153,140,033EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3038613 AgrOrtholog
Ensembl Genes ENSMUSG00000041658 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000039720 ENTREZGENE
  ENSMUST00000039720.11 UniProtKB/Swiss-Prot
  ENSMUST00000144175.3 UniProtKB/TrEMBL
Gene3D-CATH 3.30.450.190 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Gtr1_RagA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RagA/B UniProtKB/Swiss-Prot
KEGG Report mmu:245670 UniProtKB/Swiss-Prot
MGD MGI:3038613 ENTREZGENE
NCBI Gene 245670 ENTREZGENE
PANTHER PTHR11259 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAS-RELATED GTP-BINDING PROTEIN B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Gtr1_RagA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rragb PhenoGen
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B1AVD6 ENTREZGENE
  G3UYP1_MOUSE UniProtKB/TrEMBL
  Q6NTA4 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary B1AVD6 UniProtKB/Swiss-Prot