Dhrs2 (dehydrogenase/reductase member 2) - Rat Genome Database

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Gene: Dhrs2 (dehydrogenase/reductase member 2) Mus musculus
Analyze
Symbol: Dhrs2
Name: dehydrogenase/reductase member 2
RGD ID: 1553561
MGI Page MGI
Description: Predicted to enable carbonyl reductase (NADPH) activity. Predicted to be involved in several processes, including cellular response to oxidative stress; electron transport chain; and negative regulation of apoptotic process. Predicted to be located in mitochondrion; nuclear envelope; and nucleoplasm. Is expressed in lower lip and upper lip. Orthologous to human DHRS2 (dehydrogenase/reductase 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 5430405K24Rik; dehydrogenase/reductase SDR family member 2, mitochondrial; Hep27; MGC143467; SDR family member
RGD Orthologs
Human
Rat
Bonobo
Dog
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391455,459,464 - 55,478,897 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1455,459,464 - 55,478,892 (+)EnsemblGRCm39 Ensembl
GRCm381455,222,007 - 55,241,440 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1455,222,007 - 55,241,435 (+)EnsemblGRCm38mm10GRCm38
MGSCv371455,840,844 - 55,860,277 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361454,176,076 - 54,195,508 (+)NCBIMGSCv36mm8
Celera1453,027,537 - 53,046,941 (+)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-phenyl-1,2-propanedione  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
8-Br-cAMP  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
diarsenic trioxide  (ISO)
dimethylarsinous acid  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
ethyl methanesulfonate  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
genistein  (ISO)
hydrogen peroxide  (ISO)
lipopolysaccharide  (ISO)
MeIQx  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
mitoxantrone  (ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
O-methyleugenol  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (ISO)
pentanal  (ISO)
phenylmercury acetate  (ISO)
PhIP  (ISO)
propanal  (ISO)
pterostilbene  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
tanespimycin  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
thiram  (ISO)
trametinib  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:16141072   PMID:16141073   PMID:16685466   PMID:21267068   PMID:21677750   PMID:21873635   PMID:23036705   PMID:29106393  
PMID:30973865   PMID:38355793  


Genomics

Comparative Map Data
Dhrs2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391455,459,464 - 55,478,897 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1455,459,464 - 55,478,892 (+)EnsemblGRCm39 Ensembl
GRCm381455,222,007 - 55,241,440 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1455,222,007 - 55,241,435 (+)EnsemblGRCm38mm10GRCm38
MGSCv371455,840,844 - 55,860,277 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361454,176,076 - 54,195,508 (+)NCBIMGSCv36mm8
Celera1453,027,537 - 53,046,941 (+)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.12NCBI
DHRS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381423,630,115 - 23,645,639 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1423,630,115 - 23,645,639 (+)EnsemblGRCh38hg38GRCh38
GRCh371424,099,324 - 24,114,848 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361423,175,422 - 23,184,688 (+)NCBINCBI36Build 36hg18NCBI36
Build 341423,175,421 - 23,184,686NCBI
Celera143,968,304 - 3,977,579 (+)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef144,222,777 - 4,232,052 (+)NCBIHuRef
CHM1_11424,104,263 - 24,113,538 (+)NCBICHM1_1
T2T-CHM13v2.01417,830,743 - 17,846,267 (+)NCBIT2T-CHM13v2.0
Dhrs2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81532,658,855 - 32,673,591 (+)NCBIGRCr8
mRatBN7.21528,688,881 - 28,703,646 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1528,688,940 - 28,703,644 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01533,876,701 - 33,891,559 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1533,885,106 - 33,891,539 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01537,760,918 - 37,775,697 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41533,286,599 - 33,337,467 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1528,265,474 - 28,280,251 (+)NCBICelera
Cytogenetic Map15p13NCBI
LOC100976049
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21525,063,775 - 25,079,146 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11424,280,267 - 24,295,638 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0144,457,316 - 4,466,551 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11422,549,693 - 22,558,926 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1422,551,645 - 22,558,926 (+)Ensemblpanpan1.1panPan2
DHRS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.183,820,269 - 3,847,217 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl83,836,476 - 3,845,916 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha83,732,014 - 3,769,128 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.083,920,628 - 3,957,549 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl83,946,351 - 3,957,633 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.183,611,820 - 3,648,643 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.083,673,263 - 3,710,098 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.083,935,372 - 3,972,471 (+)NCBIUU_Cfam_GSD_1.0
DHRS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12924,015,535 - 24,022,897 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2924,016,071 - 24,022,500 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605922,391,461 - 22,400,491 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Dhrs2
648 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:153
Count of miRNA genes:85
Interacting mature miRNAs:92
Transcripts:ENSMUST00000022820, ENSMUST00000165432
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
1300625Cosz2_mcocaine seizure 2 (mouse)Not determined143504579768785736Mouse
1301777Bglq15_mbody growth late QTL 15 (mouse)Not determined144296241676962593Mouse
1301489Lbm10_mlean body mass 10 (mouse)Not determined145376129687761529Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142106245071885801Mouse
1301424Skull21_mskull morphology 21 (mouse)Not determined144296241676962593Mouse
4142364Pbwg18_mpostnatal body weight growth 18 (mouse)Not determined145228198486282125Mouse
4141400Nilac8_mnicotine induced locomotor activity 8 (mouse)Not determined144306584777066045Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143032195787937436Mouse
4142485Modor2_mmodifier of ocular retardation 2 (mouse)Not determined142492624858179769Mouse
4142419Tgq26_mtriglyceride QTL 26 (mouse)Not determined4033731974337319Mouse
27226737Metcl12_mmetatarsal-calcaneal length 12, 10 week (mouse)143322195759437449Mouse
1300605El5_mepilepsy 5 (mouse)Not determined144945542583455556Mouse
1301091Bbaa21_mB.burgdorferi-associated arthritis 21 (mouse)Not determined144306584777066045Mouse
4141484Hcbip1_mhexachlorobenzene induced porphyria 1 (mouse)Not determined4733525059962593Mouse
12880432Fgf23lq3_mFGF23 serum level QTL 3 (mouse)145393744087937440Mouse
1300998Cia17_mcollagen induced arthritis 17 (mouse)Not determined143033525064335381Mouse
10043887Cia50_mcollagen induced arthritis QTL 50 (mouse)Not determined143743018571430320Mouse
1300805Mors3_mmodifier of obesity related sterility 3 (mouse)Not determined144303727077037418Mouse
10043886Cia49_mcollagen induced arthritis QTL 49 (mouse)Not determined142999699463997133Mouse
14746973Manh76_mmandible shape 76 (mouse)142228721756287217Mouse
1300909Ath13_matherosclerosis 13 (mouse)Not determined143033525064335381Mouse
13506929Recrq10_mrecombination rate in male meiosis QTL 10 (mouse)142792195761137449Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000022820   ⟹   ENSMUSP00000022820
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1455,459,464 - 55,478,892 (+)Ensembl
GRCm38.p6 Ensembl1455,222,007 - 55,241,435 (+)Ensembl
Ensembl Acc Id: ENSMUST00000165432   ⟹   ENSMUSP00000129115
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1455,472,111 - 55,478,705 (+)Ensembl
GRCm38.p6 Ensembl1455,234,654 - 55,241,248 (+)Ensembl
RefSeq Acc Id: NM_027790   ⟹   NP_082066
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391455,459,464 - 55,478,897 (+)NCBI
GRCm381455,222,007 - 55,241,440 (+)NCBI
MGSCv371455,840,844 - 55,860,277 (+)RGD
Celera1453,027,537 - 53,046,941 (+)RGD
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006519570   ⟹   XP_006519633
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391455,471,341 - 55,478,897 (+)NCBI
GRCm381455,233,884 - 55,241,439 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011245200   ⟹   XP_011243502
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391455,466,189 - 55,478,897 (+)NCBI
GRCm381455,228,732 - 55,241,439 (+)NCBI
Sequence:
RefSeq Acc Id: NP_082066   ⟸   NM_027790
- UniProtKB: Q149L0 (UniProtKB/TrEMBL),   Q9D3M7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006519633   ⟸   XM_006519570
- Peptide Label: isoform X1
- UniProtKB: Q9D3M7 (UniProtKB/TrEMBL),   Q149L0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011243502   ⟸   XM_011245200
- Peptide Label: isoform X1
- UniProtKB: Q9D3M7 (UniProtKB/TrEMBL),   Q149L0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000129115   ⟸   ENSMUST00000165432
Ensembl Acc Id: ENSMUSP00000022820   ⟸   ENSMUST00000022820

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q149L0-F1-model_v2 AlphaFold Q149L0 1-282 view protein structure

Promoters
RGD ID:8682408
Promoter ID:EPDNEW_M19235
Type:single initiation site
Name:Dhrs2_1
Description:Mus musculus dehydrogenase/reductase member 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381455,222,007 - 55,222,067EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1918662 AgrOrtholog
Ensembl Genes ENSMUSG00000022209 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000022820 ENTREZGENE
  ENSMUST00000022820.12 UniProtKB/TrEMBL
  ENSMUST00000165432 ENTREZGENE
  ENSMUST00000165432.2 UniProtKB/TrEMBL
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
InterPro Glc/ribitol_DH UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
  Sc_DH/Rdtase_CS UniProtKB/TrEMBL
KEGG Report mmu:71412 UniProtKB/TrEMBL
MGD MGI:1918662 ENTREZGENE
NCBI Gene 71412 ENTREZGENE
PANTHER DEHYDROGENASE/REDUCTASE (SDR FAMILY) MEMBER 4 UniProtKB/TrEMBL
  DEHYDROGENASE/REDUCTASE MEMBER 2 UniProtKB/TrEMBL
Pfam adh_short_C2 UniProtKB/TrEMBL
PhenoGen Dhrs2 PhenoGen
PRINTS GDHRDH UniProtKB/TrEMBL
  SDRFAMILY UniProtKB/TrEMBL
PROSITE ADH_SHORT UniProtKB/TrEMBL
Superfamily-SCOP SSF51735 UniProtKB/TrEMBL
UniProt Q149L0 ENTREZGENE, UniProtKB/TrEMBL
  Q9D3M7 ENTREZGENE, UniProtKB/TrEMBL