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Gene: Il2 (interleukin 2) Mus musculus
Symbol: Il2
Name: interleukin 2
Description: Exhibits cytokine activity and interleukin-2 receptor binding activity. Involved in several processes, including extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of macromolecule metabolic process; and regulation of lymphocyte activation. Localizes to extracellular space. Is expressed in liver; omental bursa; thymus; and thymus primordium. Used to study Sjogren's syndrome and inflammatory bowel disease. Human ortholog(s) of this gene implicated in several diseases, including auditory system disease (multiple); autoimmune hypersensitivity disease (multiple); carcinoma (multiple); dermatitis (multiple); and vasculitis (multiple). Orthologous to human IL2 (interleukin 2); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-2 signaling pathway; interleukin-23 signaling pathway; INTERACTS WITH 1,3-benzothiazole-2-thiol; 1,4-phenylenediamine; 1-chloro-2,4-dinitrobenzene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Il-2; interleukin-2; T-cell growth factor; TCGF
Homo sapiens (human) : IL2 (interleukin 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Il2 (interleukin 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Il2 (interleukin 2)
Pan paniscus (bonobo/pygmy chimpanzee) : IL2 (interleukin 2)
Canis lupus familiaris (dog) : IL2 (interleukin 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Il2 (interleukin 2)
Sus scrofa (pig) : IL2 (interleukin 2)
Chlorocebus sabaeus (African green monkey) : IL2 (interleukin 2)
Heterocephalus glaber (naked mole-rat) : Il2 (interleukin 2)
more info ...
Is Marker For: QTLs:   OSTEAR13_H  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl337,120,523 - 37,125,959 (-)EnsemblGRCm38mm10GRCm38
GRCm38337,120,713 - 37,125,954 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37337,019,635 - 37,024,876 (-)NCBIGRCm37mm9NCBIm37
MGSCv36337,312,271 - 37,317,502 (-)NCBImm8
Celera337,007,247 - 37,012,480 (-)NCBICelera
Cytogenetic Map3BNCBI
cM Map318.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Il2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733315
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.