Il2 (interleukin 2) - Rat Genome Database

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Gene: Il2 (interleukin 2) Mus musculus
Analyze
Symbol: Il2
Name: interleukin 2
RGD ID: 733315
MGI Page MGI
Description: Enables cytokine activity and interleukin-2 receptor binding activity. Involved in negative regulation of T-helper 17 cell differentiation. Acts upstream of or within several processes, including extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of macromolecule metabolic process; and regulation of lymphocyte activation. Located in extracellular space. Is expressed in liver; omental bursa; thymus; and thymus primordium. Used to study Sjogren's syndrome and inflammatory bowel disease. Human ortholog(s) of this gene implicated in several diseases, including Takayasu's arteritis; auditory system disease (multiple); autoimmune disease (multiple); carcinoma (multiple); and neurodegenerative disease (multiple). Orthologous to human IL2 (interleukin 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: IL; Il-2; interleukin-2; T-cell growth factor; TCGF
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: QTLs:   OSTEAR13_H  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39337,174,862 - 37,180,103 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl337,174,672 - 37,180,108 (-)EnsemblGRCm39 Ensembl
GRCm38337,120,713 - 37,125,954 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl337,120,523 - 37,125,959 (-)EnsemblGRCm38mm10GRCm38
MGSCv37337,019,635 - 37,024,876 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36337,312,271 - 37,317,502 (-)NCBIMGSCv36mm8
Celera337,007,247 - 37,012,480 (-)NCBICelera
Cytogenetic Map3BNCBI
cM Map318.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acquired immunodeficiency syndrome  (ISO)
Acute Lung Injury  (ISO)
adult T-cell leukemia/lymphoma  (ISO)
aggressive periodontitis  (ISO)
allergic contact dermatitis  (ISO)
allergic disease  (IMP)
allergic rhinitis  (ISO)
alopecia areata  (IMP,ISO)
Alzheimer's disease  (ISO)
Amebic Liver Abscess  (ISO)
amnestic disorder  (ISO)
anemia  (ISO)
anogenital venereal wart  (ISO)
Anorexia  (ISO)
Asthenia  (ISO)
asthma  (ISO)
ataxia telangiectasia  (ISO)
atherosclerosis  (IEP)
atopic dermatitis  (IMP,ISO)
atrial fibrillation  (ISO)
autistic disorder  (ISO)
autoimmune hepatitis  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
bacterial infectious disease  (ISO)
Behcet's disease  (ISO)
birdshot chorioretinopathy  (ISO)
brain infarction  (ISO)
Brain Injuries  (ISO)
Brain Neoplasms  (ISO)
Breast Neoplasms  (ISO)
bullous pemphigoid  (ISO)
Carcinoma, Lewis Lung  (IDA)
cholestasis  (IDA)
cholesteatoma of middle ear  (ISO)
Choroidal Neovascularization  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
colorectal carcinoma  (ISO)
Coronavirus infectious disease  (IEP)
COVID-19  (ISO)
cystitis  (ISO)
disease of cellular proliferation  (ISO)
drug allergy  (ISO)
Drug Eruptions  (ISO)
Entamoebiasis  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Uveoretinitis  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Melanoma  (ISO)
Experimental Neoplasms  (ISO)
Femoral Fractures  (ISO)
Fever  (ISO)
glioblastoma  (ISO)
glomerulonephritis  (ISO)
graft-versus-host disease  (ISO)
Graves ophthalmopathy  (ISO)
Graves' disease  (ISO)
head and neck squamous cell carcinoma  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
herpes zoster  (ISO)
high grade glioma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (ISO)
Hyperalgesia  (ISO)
Hyperkinesis  (ISO)
Hypotension  (ISO)
inflammatory bowel disease  (IAGP)
interstitial lung disease  (ISO)
juvenile rheumatoid arthritis  (ISO)
Kidney Neoplasms  (ISO)
Knee Osteoarthritis  (ISO)
leishmaniasis  (IDA)
leukemia  (ISO)
leukopenia  (ISO)
limited scleroderma  (ISO)
liver cirrhosis  (IDA)
Liver Metastasis  (ISO)
Liver Neoplasms  (ISO)
lung disease  (ISO)
Lung Neoplasms  (ISO)
major depressive disorder  (ISO)
melanoma  (ISO)
Multi-Infarct Dementia  (ISO)
Neoplasm Metastasis  (ISO)
Neoplasm, Residual  (ISO)
nephrotic syndrome  (ISO)
neurodevelopmental disorder with hearing loss, seizures, and brain abnormalities  (ISO)
Neurodevelopmental Disorders  (ISO)
Neurogenic Inflammation  (ISO)
open-angle glaucoma  (ISO)
Oral Lichen Planus  (ISO)
oral squamous cell carcinoma  (ISO)
otitis media  (IEP)
Pain  (ISO)
pancreatic cancer  (ISO)
pemphigus  (ISO)
Perennial Allergic Rhinitis  (ISO)
Plaque, Atherosclerotic  (IEP)
post-traumatic stress disorder  (ISO)
primary immunodeficiency disease  (ISO)
Prostatic Neoplasms  (ISO)
psoriasis  (ISO)
Pulmonary Arterial Hypertension  (ISO)
renal cell carcinoma  (ISO)
rheumatoid arthritis  (ISO)
rhinitis  (ISO)
sensorineural hearing loss  (ISO)
severe combined immunodeficiency  (ISO)
sinusitis  (ISO)
Sjogren's syndrome  (IAGP)
squamous cell carcinoma  (ISO)
Staphylococcal Infections  (IEP)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
Takayasu's arteritis  (ISO)
tongue squamous cell carcinoma  (ISO)
Transplant Rejection  (IDA,IMP,ISO)
type 1 diabetes mellitus  (IMP,ISO)
urinary bladder cancer  (ISO)
uveitis  (ISO)
Vaginal Neoplasms  (ISO)
viral hepatitis  (ISO)
vitiligo  (ISO)
Zellweger syndrome  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-pilocarpine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-lipoic acid  (ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-benzothiazole-2-thiol  (EXP)
1,4-phenylenediamine  (EXP)
1-chloro-2,4-dinitrobenzene  (EXP)
1-fluoro-2,4-dinitrobenzene  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
1-naphthaleneacetic acid  (EXP)
15-acetyldeoxynivalenol  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4-D  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-arachidonoylglycerol  (ISO)
2-ethylhexan-1-ol  (EXP)
2-tert-butylhydroquinone  (ISO)
3'-O-(4-Benzoyl)benzoyl ATP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3'-diindolylmethane  (EXP)
3-acetyldeoxynivalenol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4'-epidoxorubicin  (EXP)
4'-hydroxydiclofenac  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-aminobenzoic acid  (EXP)
4-hydroxynon-2-enal  (EXP)
4-nitroaniline  (ISO)
4-tolyl isocyanate  (EXP)
5'-S-methyl-5'-thioadenosine  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
7,12-dimethyltetraphene  (EXP)
7,8-dihydroxycoumarin  (ISO)
9-cis-retinoic acid  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
actinomycin D  (ISO)
adenosine  (EXP)
alclometasone dipropionate  (ISO)
aldehydo-D-glucosamine  (EXP)
aldicarb  (EXP)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
alpha-hexylcinnamaldehyde  (EXP)
alprazolam  (EXP)
aluminium hydroxide  (EXP)
amiodarone  (ISO)
ammonium chloride  (ISO)
Ammothamnine  (ISO)
amphotericin B  (ISO)
andrographolide  (ISO)
anethole  (EXP)
anthracen-2-amine  (ISO)
arjunolic acid  (ISO)
arotinoid acid  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
bathocuproine disulfonic acid  (ISO)
benzamide  (ISO)
benzene  (EXP,ISO)
benzethonium chloride  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzocaine  (EXP)
berberine  (EXP)
beryllium sulfate  (EXP)
beta-D-glucosamine  (EXP)
beta-endorphin  (ISO)
betamethasone valerate  (ISO)
betulin  (EXP)
bifenthrin  (EXP)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
boric acid  (ISO)
boron atom  (ISO)
bromodichloromethane  (EXP)
buprenorphine  (ISO)
butan-1-ol  (ISO)
butane-2,3-dione  (EXP)
Butylphthalide  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
Calcimycin  (ISO)
calcitriol  (EXP,ISO)
cannabidiol  (EXP,ISO)
Cannabinol  (EXP)
capsaicin  (EXP,ISO)
capsazepine  (EXP)
carbamazepine  (ISO)
carbaryl  (EXP)
carbofuran  (EXP)
carbon dioxide  (ISO)
carbon nanotube  (EXP,ISO)
celecoxib  (ISO)
cerium trichloride  (EXP)
chloromethylisothiazolinone  (EXP)
chloroquine  (EXP,ISO)
chlorpromazine  (ISO)
choline  (EXP)
chromium(6+)  (ISO)
ciglitazone  (ISO)
ciprofloxacin  (ISO)
cis-caffeic acid  (EXP)
cisplatin  (EXP,ISO)
citral  (EXP,ISO)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
coformycin  (EXP)
copper(II) nitrate  (ISO)
cordycepin  (ISO)
cortisol  (ISO)
coumestrol  (ISO)
crotonaldehyde  (ISO)
curcumin  (EXP,ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
dapsone  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (EXP,ISO)
deoxynivalenol  (EXP,ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
Dibenzo[a,i]pyrene  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
dichlorvos  (EXP)
diclofenac  (ISO)
dieldrin  (ISO)
diethanolamine  (ISO)
digoxin  (ISO)
diiodine  (EXP,ISO)
diisopropyl fluorophosphate  (EXP)
Dimaprit  (EXP)
dimethyl sulfoxide  (ISO)
dimethyl-(phenylmethyl)-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]ammonium  (ISO)
diphenylmethane-4,4'-diisocyanate  (EXP)
dipyridamole  (EXP)
doxorubicin  (EXP,ISO)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (EXP)
elemental boron  (ISO)
elemental selenium  (ISO)
emamectin benzoate  (ISO)
endosulfan  (EXP)
erlotinib hydrochloride  (EXP)
ethanol  (EXP)
eugenol  (EXP)
famotidine  (EXP)
fenitrothion  (ISO)
fentanyl  (ISO)
ferric oxide  (EXP)
fluticasone  (ISO)
folic acid  (ISO)
formaldehyde  (EXP,ISO)
fragrance  (ISO)
fructose  (ISO)
fumigaclavine C  (EXP)
fumonisin B1  (EXP)
gamma-linolenic acid  (ISO)
Gastrodin  (EXP)
genistein  (ISO)
geranial  (EXP,ISO)
Glutathione ethyl ester  (ISO)
Goe 6976  (ISO)
graphite  (EXP)
heroin  (ISO)
hexachlorobenzene  (ISO)
histamine  (EXP,ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
imidurea  (EXP)
imiquimod  (ISO)
indirubin-3'-monoxime  (EXP)
indole-3-acetic acid  (EXP)
indole-3-methanol  (EXP)
indometacin  (EXP,ISO)
ionomycin  (EXP,ISO)
irinotecan  (ISO)
isoeugenol  (EXP)
isoniazide  (ISO)
isophorone diisocyanate  (ISO)
isoprenaline  (ISO)
isotretinoin  (ISO)
KN-93  (EXP)
L-arginine  (ISO)
lactacystin  (EXP)
lead diacetate  (ISO)
lead nitrate  (ISO)
lead(II) chloride  (ISO)
lenalidomide  (ISO)
levamisole  (EXP)
linoleic acid  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (EXP)
lithium carbonate  (ISO)
lithium chloride  (EXP)
lithium hydride  (EXP)
loperamide  (ISO)
LY294002  (ISO)
lycopene  (EXP)
magnesium dihydroxide  (EXP)
malathion  (EXP)
malonaldehyde  (EXP)
mancozeb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
MC1568  (EXP)
medroxyprogesterone acetate  (ISO)
melatonin  (EXP,ISO)
mercury atom  (ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (ISO)
mesalamine  (ISO)
methadone  (ISO)
methanol  (EXP,ISO)
methiocarb  (EXP)
methotrexate  (ISO)
methoxychlor  (ISO)
methyl isocyanate  (ISO)
methylmercury chloride  (ISO)
mevinphos  (EXP)
microcystin-LR  (ISO)
mifepristone  (EXP,ISO)
minocycline  (ISO)
mitogen  (EXP,ISO)
mitomycin C  (ISO)
mocetinostat  (EXP)
mono(2-ethylhexyl) phthalate  (EXP)
monocrotophos  (EXP)
Monocyte locomotion inhibitory factor  (ISO)
monodansylcadaverine  (EXP)
monosodium L-glutamate  (ISO)
morphine  (EXP,ISO)
mycophenolic acid  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP)
N,N-bis(2-hydroxypropyl)nitrosamine  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (ISO)
N-methyl-N-nitrosourea  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
naloxone  (ISO)
naproxen  (ISO)
naringin  (EXP)
neocuproine  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (EXP,ISO)
nicotinamide  (ISO)
nicotine  (ISO)
nilotinib  (ISO)
nitrofurazone  (ISO)
nitroprusside  (ISO)
Nivalenol  (EXP,ISO)
nonanoic acid  (EXP)
NORCANTHARIDIN  (ISO)
notoginsenoside R1  (EXP)
o-anisidine  (ISO)
ochratoxin A  (ISO)
oridonin  (ISO)
oxidopamine  (EXP)
ozone  (EXP)
p-menthan-3-ol  (ISO)
Paeonol  (EXP)
paracetamol  (ISO)
paraoxon  (EXP)
paraquat  (EXP,ISO)
PCB138  (ISO)
PD 0325901  (ISO)
pentachlorophenol  (EXP)
pentamidine  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
permethrin  (ISO)
phenanthridone  (ISO)
phenethyl caffeate  (ISO)
phenyl benzoate  (EXP)
PhIP  (EXP)
phloretin  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phthalic anhydride  (EXP)
piperazine  (ISO)
piperidine  (EXP,ISO)
piperine  (EXP)
poly(I:C)  (EXP,ISO)
poly(methyl methacrylate) macromolecule  (ISO)
pomalidomide  (ISO)
prednisolone  (EXP)
proanthocyanidin  (ISO)
progesterone  (ISO)
propanil  (EXP)
prostaglandin E2  (ISO)
pyrazoles  (ISO)
Pyridostigmine bromide  (EXP)
pyrimethamine  (ISO)
pyrrolidine dithiocarbamate  (EXP,ISO)
quercetin  (EXP,ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
Rhein  (EXP)
ribavirin  (EXP,ISO)
rimexolone  (ISO)
rottlerin  (ISO)
S-adenosyl-L-methioninate  (EXP)
S-adenosyl-L-methionine  (EXP)
SB 203580  (ISO)
selenium atom  (ISO)
semaxanib  (ISO)
serpentine asbestos  (ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
silychristin  (ISO)
simvastatin  (EXP)
sirolimus  (EXP,ISO)
sodium acetate trihydrate  (ISO)
sodium arsenite  (EXP,ISO)
sodium bromate  (ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (EXP)
sodium fluoride  (ISO)
sodium hexachloroplatinate  (EXP)
spironolactone  (ISO)
SR 144528  (ISO)
streptozocin  (ISO)
sulfasalazine  (EXP,ISO)
sulforaphane  (EXP)
sulfur dioxide  (ISO)
sumatriptan  (ISO)
Sunset Yellow FCF  (EXP)
syringic acid  (ISO)
T-2 toxin  (EXP)
tacrolimus (anhydrous)  (ISO)
tacrolimus hydrate  (EXP,ISO)
tamoxifen  (EXP)
Terfenadine  (ISO)
tert-butanol  (ISO)
tetrachloromethane  (EXP,ISO)
tetrathiomolybdate(2-)  (EXP)
thalidomide  (EXP,ISO)
Theaflavin 3,3'-digallate  (EXP)
theophylline  (EXP)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
tofacitinib  (EXP)
toluene  (EXP)
toluene 2,4-diisocyanate  (EXP)
trans-anethole  (EXP)
trans-caffeic acid  (EXP)
trans-isoeugenol  (EXP)
Tributyltin oxide  (EXP,ISO)
tributyrin  (ISO)
trichloroacetic acid  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (EXP)
triethanolamine  (ISO)
trimellitic anhydride  (EXP)
tropisetron  (ISO)
Tungsten carbide  (ISO)
urethane  (EXP,ISO)
ursodeoxycholic acid  (EXP)
verrucarin A  (EXP)
vincristine  (ISO)
vitamin E  (ISO)
warfarin  (ISO)
zearalenone  (EXP)
zidovudine  (ISO)
zinc atom  (EXP,ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activated T cell proliferation  (IDA,IMP)
adaptive immune response  (IEA)
cell surface receptor signaling pathway via STAT  (IEA)
extrinsic apoptotic signaling pathway in absence of ligand  (IDA)
G protein-coupled receptor signaling pathway  (ISO)
gene expression  (IDA)
interleukin-2-mediated signaling pathway  (IEA,ISO)
leukocyte activation involved in immune response  (IEA,ISO)
lymphocyte proliferation  (IMP)
negative regulation of B cell apoptotic process  (ISO)
negative regulation of inflammatory response  (IMP)
negative regulation of lymphocyte proliferation  (IMP)
negative regulation of protein phosphorylation  (ISO)
negative regulation of T-helper 17 cell differentiation  (IGI)
phospholipase C-activating G protein-coupled receptor signaling pathway  (ISO)
positive regulation of activated T cell proliferation  (IDA,IMP,ISO)
positive regulation of B cell proliferation  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of dendritic spine development  (ISO)
positive regulation of immunoglobulin production  (IMP,ISO)
positive regulation of interleukin-17 production  (IEA,ISO)
positive regulation of isotype switching to IgG isotypes  (IMP)
positive regulation of plasma cell differentiation  (IEA,ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of regulatory T cell differentiation  (ISO)
positive regulation of T cell differentiation  (ISO)
positive regulation of T cell proliferation  (IDA,IMP,ISO)
positive regulation of transcription by RNA polymerase II  (IDA)
positive regulation of type II interferon production  (IDA)
positive regulation of tyrosine phosphorylation of STAT protein  (IDA,ISO)
regulation of CD4-positive, alpha-beta T cell proliferation  (IMP)
regulation of T cell homeostatic proliferation  (IMP)
response to ethanol  (ISO)
response to tacrolimus  (ISO)
T cell proliferation  (IDA)
transcription by RNA polymerase II  (IDA)
tyrosine phosphorylation of STAT protein  (IDA)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Severity of mucosal inflammation as a predictor for alterations of visceral sensory function in a rat model. Adam B, etal., Pain. 2006 Jul;123(1-2):179-86. Epub 2006 Apr 12.
2. Tumour necrosis factor-alpha and interleukin-2 in pus aspirate and blood in patients with amoebic liver abscess. Agarwal SK, etal., J Assoc Physicians India. 1999 Nov;47(11):1065-7.
3. Immunologic studies in patients with Takayasu's arteritis. III. Immunoregulatory changes. Alcocer-Varela J, etal., Clin Exp Rheumatol. 1989 Jul-Aug;7(4):345-50.
4. Immunological predictors of different responses to combination therapy with interferon alpha and ribavirin in patients with chronic hepatitis C. Amaraa R, etal., J Gastroenterol. 2003;38(3):254-9. doi: 10.1007/s005350300044.
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PMID:12734339   PMID:12734352   PMID:12759423   PMID:12824305   PMID:12847246   PMID:12851881   PMID:12874832   PMID:12933895   PMID:12960172   PMID:12960297   PMID:12964046   PMID:14500638  
PMID:14500652   PMID:14513297   PMID:14525977   PMID:14634080   PMID:14652292   PMID:14670302   PMID:14679059   PMID:14707112   PMID:14715519   PMID:14762166   PMID:14764683   PMID:14969693  
PMID:15010863   PMID:15020598   PMID:15034008   PMID:15039318   PMID:15087456   PMID:15100283   PMID:15108363   PMID:15128779   PMID:15128787   PMID:15195696   PMID:15213134   PMID:15307180  
PMID:15314038   PMID:15316245   PMID:15339668   PMID:15347678   PMID:15353479   PMID:15494488   PMID:15520045   PMID:15546395   PMID:15563987   PMID:15611254   PMID:15637136   PMID:15640801  
PMID:15661875   PMID:15699158   PMID:15707895   PMID:15710467   PMID:15728465   PMID:15746085   PMID:15753206   PMID:15753210   PMID:15778352   PMID:15804292   PMID:15814687   PMID:15829231  
PMID:15844705   PMID:15850801   PMID:15894169   PMID:15937196   PMID:15951352   PMID:15972639   PMID:15976176   PMID:16081806   PMID:16081807   PMID:16148127   PMID:16154177   PMID:16195331  
PMID:16227983   PMID:16227984   PMID:16244650   PMID:16287710   PMID:16301639   PMID:16339532   PMID:16339537   PMID:16443792   PMID:16444260   PMID:16450143   PMID:16493033   PMID:16493044  
PMID:16564704   PMID:16585571   PMID:16621991   PMID:16709807   PMID:16751372   PMID:16769892   PMID:16778891   PMID:16785514   PMID:16791878   PMID:16809611   PMID:16879997   PMID:16880512  
PMID:16918699   PMID:16920933   PMID:17015680   PMID:17015695   PMID:17015719   PMID:17035345   PMID:17067314   PMID:17083048   PMID:17096403   PMID:17116877   PMID:17130300   PMID:17142725  
PMID:17142732   PMID:17148585   PMID:17182552   PMID:17182561   PMID:17182565   PMID:17207605   PMID:17213291   PMID:17227909   PMID:17237369   PMID:17237392   PMID:17237413   PMID:17274112  
PMID:17277105   PMID:17277778   PMID:17312008   PMID:17363300   PMID:17371960   PMID:17372610   PMID:17442938   PMID:17470640   PMID:17524378   PMID:17554057   PMID:17617853   PMID:17641006  
PMID:17646407   PMID:17664293   PMID:17664294   PMID:17671507   PMID:17692504   PMID:17699744   PMID:17709498   PMID:17726538   PMID:17875988   PMID:17923507   PMID:17938253   PMID:17939120  
PMID:17947634   PMID:17951529   PMID:17965948   PMID:17967903   PMID:17981641   PMID:17982458   PMID:18034419   PMID:18040286   PMID:18056343   PMID:18056362   PMID:18155708   PMID:18156621  
PMID:18202762   PMID:18209086   PMID:18276844   PMID:18305217   PMID:18309287   PMID:18310063   PMID:18329639   PMID:18354172   PMID:18354238   PMID:18378701   PMID:18390713   PMID:18398504  
PMID:18413772   PMID:18424696   PMID:18430737   PMID:18438410   PMID:18451996   PMID:18465774   PMID:18481948   PMID:18506879   PMID:18545662   PMID:18571443   PMID:18581325   PMID:18606681  
PMID:18635804   PMID:18674934   PMID:18676770   PMID:18704316   PMID:18714000   PMID:18721759   PMID:18725523   PMID:18726679   PMID:18778283   PMID:18780166   PMID:18815283   PMID:18820682  
PMID:18832679   PMID:18931080   PMID:18941182   PMID:18941219   PMID:18990450   PMID:19017930   PMID:19077880   PMID:19109148   PMID:19136564   PMID:19139201   PMID:19218564   PMID:19230866  
PMID:19249230   PMID:19342623   PMID:19362089   PMID:19447046   PMID:19454662   PMID:19549859   PMID:19553521   PMID:19561321   PMID:19648271   PMID:19805141   PMID:19880748   PMID:19896394  
PMID:19901518   PMID:19901991   PMID:19955658   PMID:20007535   PMID:20018660   PMID:20041187   PMID:20049877   PMID:20089076   PMID:20090908   PMID:20096607   PMID:20132230   PMID:20133667  
PMID:20133862   PMID:20233578   PMID:20351308   PMID:20402674   PMID:20483725   PMID:20570629   PMID:20623548   PMID:20624944   PMID:20641004   PMID:20686022   PMID:20851384   PMID:20856822  
PMID:20881183   PMID:20890046   PMID:21037095   PMID:21037099   PMID:21039426   PMID:21059770   PMID:21155952   PMID:21160039   PMID:21169543   PMID:21198751   PMID:21244339   PMID:21262836  
PMID:21278738   PMID:21282039   PMID:21292764   PMID:21297642   PMID:21297643   PMID:21364747   PMID:21389253   PMID:21389258   PMID:21430221   PMID:21435588   PMID:21439091   PMID:21460206  
PMID:21469091   PMID:21502514   PMID:21516110   PMID:21518728   PMID:21525380   PMID:21576463   PMID:21577143   PMID:21593413   PMID:21606942   PMID:21669253   PMID:21804558   PMID:21820502  
PMID:21832163   PMID:21849500   PMID:21862595   PMID:21880986   PMID:21890374   PMID:21905022   PMID:21928285   PMID:21937990   PMID:22012243   PMID:22017689   PMID:22147766   PMID:22147768  
PMID:22176676   PMID:22219356   PMID:22312128   PMID:22327125   PMID:22355096   PMID:22387543   PMID:22406686   PMID:22442347   PMID:22464171   PMID:22464450   PMID:22579352   PMID:22590468  
PMID:22645657   PMID:22665806   PMID:22682244   PMID:22684523   PMID:22732586   PMID:22751139   PMID:22778392   PMID:22834482   PMID:22860011   PMID:22915781   PMID:22933631   PMID:22942433  
PMID:22954711   PMID:22968459   PMID:22972922   PMID:22983538   PMID:22999060   PMID:23027937   PMID:23039181   PMID:23071696   PMID:23079711   PMID:23146537   PMID:23180662   PMID:23195496  
PMID:23198850   PMID:23209314   PMID:23262141   PMID:23275607   PMID:23296706   PMID:23332616   PMID:23335749   PMID:23359502   PMID:23395675   PMID:23416322   PMID:23427250   PMID:23645880  
PMID:23650439   PMID:23650440   PMID:23650441   PMID:23670188   PMID:23690575   PMID:23715742   PMID:23762323   PMID:23791643   PMID:23805138   PMID:23833258   PMID:23834842   PMID:23895744  
PMID:23898202   PMID:23918371   PMID:24019486   PMID:24051241   PMID:24055061   PMID:24101548   PMID:24117537   PMID:24146810   PMID:24205242   PMID:24244020   PMID:24249704   PMID:24281729  
PMID:24291244   PMID:24416451   PMID:24446516   PMID:24454872   PMID:24550509   PMID:24586481   PMID:24605680   PMID:24633065   PMID:24778448   PMID:24909888   PMID:24929185   PMID:24938868  
PMID:24984151   PMID:25015830   PMID:25019288   PMID:25063866   PMID:25063876   PMID:25092334   PMID:25171404   PMID:25218473   PMID:25267612   PMID:25323825   PMID:25339665   PMID:25369785  
PMID:25548233   PMID:25550088   PMID:25585987   PMID:25590474   PMID:25642768   PMID:25652593   PMID:25708328   PMID:25939026   PMID:26025126   PMID:26062998   PMID:26160380   PMID:26170384  
PMID:26268655   PMID:26351138   PMID:26365183   PMID:26365185   PMID:26404745   PMID:26410627   PMID:26426795   PMID:26433463   PMID:26453748   PMID:26468284   PMID:26507712   PMID:26529512  
PMID:26581993   PMID:26605524   PMID:26743592   PMID:26744474   PMID:26752201   PMID:26763864   PMID:26853809   PMID:26950239   PMID:26974045   PMID:26975190   PMID:27018889   PMID:27147029  
PMID:27322555   PMID:27363266   PMID:27477778   PMID:27573835   PMID:27708334   PMID:27787514   PMID:27914701   PMID:28025040   PMID:28035902   PMID:28064242   PMID:28074895   PMID:28116088  
PMID:28159902   PMID:28219835   PMID:28362433   PMID:28396406   PMID:28438897   PMID:28468971   PMID:28507024   PMID:28539382   PMID:28540653   PMID:28542613   PMID:28646040   PMID:28747670  
PMID:28835458   PMID:28849104   PMID:28948612   PMID:29018045   PMID:29078395   PMID:29127008   PMID:29549257   PMID:29662170   PMID:29728511   PMID:29743314   PMID:30143634   PMID:30213884  
PMID:30380412   PMID:30382149   PMID:30560927   PMID:30662436   PMID:30692571   PMID:30944470   PMID:31217192   PMID:31262730   PMID:31285535   PMID:31434685   PMID:31614462   PMID:31632413  
PMID:31663508   PMID:32052406   PMID:32184322   PMID:32187647   PMID:32327706   PMID:32332067   PMID:32376651   PMID:32735645   PMID:32739457   PMID:32840576   PMID:32930455   PMID:32966792  
PMID:33162030   PMID:33293462   PMID:33432230   PMID:33838102   PMID:33855972   PMID:34108258   PMID:34157302   PMID:34665220   PMID:34869064   PMID:35104810   PMID:35148200   PMID:35213210  
PMID:35699942   PMID:35849090   PMID:36059465   PMID:36074916   PMID:36159793   PMID:36362187   PMID:36428964   PMID:36430328   PMID:36610224   PMID:36705564   PMID:37040404   PMID:37086778  
PMID:37307442   PMID:37536708   PMID:37594278   PMID:38378682   PMID:38427718   PMID:38490213   PMID:38551395   PMID:38861924   PMID:39191751   PMID:39214091  


Genomics

Comparative Map Data
Il2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39337,174,862 - 37,180,103 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl337,174,672 - 37,180,108 (-)EnsemblGRCm39 Ensembl
GRCm38337,120,713 - 37,125,954 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl337,120,523 - 37,125,959 (-)EnsemblGRCm38mm10GRCm38
MGSCv37337,019,635 - 37,024,876 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36337,312,271 - 37,317,502 (-)NCBIMGSCv36mm8
Celera337,007,247 - 37,012,480 (-)NCBICelera
Cytogenetic Map3BNCBI
cM Map318.3NCBI
IL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384122,451,470 - 122,456,725 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4122,451,470 - 122,456,725 (-)EnsemblGRCh38hg38GRCh38
GRCh374123,372,625 - 123,377,880 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364123,592,075 - 123,597,100 (-)NCBINCBI36Build 36hg18NCBI36
Build 344123,730,232 - 123,735,485NCBI
Celera4120,756,030 - 120,761,055 (-)NCBICelera
Cytogenetic Map4q27NCBI
HuRef4119,099,231 - 119,104,256 (-)NCBIHuRef
CHM1_14123,349,113 - 123,354,138 (-)NCBICHM1_1
T2T-CHM13v2.04125,755,609 - 125,760,864 (-)NCBIT2T-CHM13v2.0
Il2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82121,932,968 - 121,937,672 (-)NCBIGRCr8
mRatBN7.22120,004,862 - 120,009,566 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2120,004,862 - 120,009,566 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2126,574,220 - 126,578,924 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02124,686,729 - 124,691,433 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02119,315,685 - 119,320,389 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02123,847,150 - 123,851,854 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2123,847,150 - 123,851,854 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02143,460,866 - 143,465,570 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42123,655,005 - 123,659,709 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12123,599,966 - 123,604,671 (-)NCBI
Celera2114,959,889 - 114,964,593 (-)NCBICelera
Cytogenetic Map2q25NCBI
Il2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542818,162,467 - 18,168,265 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542818,163,010 - 18,168,157 (+)NCBIChiLan1.0ChiLan1.0
IL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23120,236,205 - 120,241,463 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14120,502,088 - 120,507,347 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04114,637,328 - 114,642,586 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14125,782,563 - 125,787,819 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4125,782,563 - 125,787,984 (-)Ensemblpanpan1.1panPan2
IL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11917,750,780 - 17,756,394 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1917,750,780 - 17,756,394 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1917,968,837 - 17,974,439 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01917,869,103 - 17,874,712 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1917,869,103 - 17,874,712 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11917,821,680 - 17,827,284 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01918,101,949 - 18,107,555 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01918,572,248 - 18,577,858 (+)NCBIUU_Cfam_GSD_1.0
Il2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530165,520,154 - 65,524,908 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366621,594,953 - 1,599,625 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366621,594,953 - 1,599,625 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8101,640,944 - 101,645,609 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18101,640,938 - 101,645,683 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28108,797,437 - 108,802,149 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1769,729,635 - 69,736,279 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl769,730,282 - 69,734,969 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603748,691,838 - 48,697,094 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247772,885,535 - 2,890,453 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247772,885,537 - 2,890,453 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Il2
16 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:161
Count of miRNA genes:135
Interacting mature miRNAs:154
Transcripts:ENSMUST00000029275
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
14746977Manh53_mmandible shape 53 (mouse)33592528069925280Mouse
15039332Nmrs6_mNAFLD-associated magnetic resonance shift 6 (mouse)33417074168170741Mouse
4141116Lgaq4_mlate growth adjusted QTL 4 (mouse)Not determined1024922183184946Mouse
1357584Splq6_mspleen weight QTL 6 (mouse)Not determined31024922183184946Mouse
4141563Lgq3_mlate growth QTL 3 (mouse)Not determined1024922183184946Mouse
15039336Nmrs2_mNAFLD-associated magnetic resonance shift 2 (mouse)33457610368576103Mouse
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
1357440Hrtpq1_mheart weight percentage QTL 1 (mouse)Not determined31024922183184946Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
1558925Hivan1_mHIV-associated nephropathy 1 (mouse)Not determined3758617468716946Mouse
9587784Afw13_mabdominal fat weight QTL 13 (mouse)Not determined33375204567752228Mouse
39128206Lwq18_mliver weight QTL 18 (mouse)31024922183184946Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
1300559Thypr3_mthymocyte proliferative response 3 (mouse)Not determined3452541938525519Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
1301114Ssial2_msusceptibility to sialadenitis 2 (mouse)Not determined32017486254180103Mouse
1357689Mdmsc1_mmodifier of muscularity 1 (mouse)Not determined33332720145916479Mouse
18337272Bmd46_mbone mineral density 46, males (mouse)33540742169407421Mouse
1300961Bh4p_mbar holding four paws (mouse)Not determined33183785465837997Mouse
4142092Tgq13_mtriglyceride QTL 13 (mouse)Not determined1828816852288168Mouse
10043882Bwtq13_mbody weight QTL 13 (mouse)Not determined33375204567752228Mouse
10412073Ssen2_msuseptibility to Sendai virus 2 (mouse)Not determined33353546567535615Mouse
1300587Aod2_mautoimmune ovarian dysgenesis 2 (mouse)Not determined33717974268716946Mouse
4141255W10q3_mweight 10 weeks QTL 3 (mouse)Not determined1024922183184946Mouse
12910781Pwgrq12_mpost-weaning growth rate QTL 12 (mouse)33263576058017363Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1301358Eae20_mexperimental allergic encephalomyelitis 20 (mouse)Not determined31163045345630591Mouse
12910778Pwgrq13_mpost-weaning growth rate QTL 13 (mouse)33263576058017363Mouse