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Gene: Kmt5a (lysine methyltransferase 5A) Mus musculus
Symbol: Kmt5a
Name: lysine methyltransferase 5A
Description: Predicted to have histone-lysine N-methyltransferase activity; p53 binding activity; and transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; peptidyl-lysine monomethylation; and regulation of DNA damage response, signal transduction by p53 class mediator. Predicted to localize to the cytosol and nucleoplasm. Is expressed in embryo. Orthologous to human KMT5A (lysine methyltransferase 5A); PARTICIPATES IN histone modification pathway; methionine cycle/metabolic pathway; p53 signaling pathway; INTERACTS WITH 2,3',4,4',5-Pentachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2410195B05Rik; AA617402; AW536475; H4-K20-HMTase KMT5A; H4-K20-HMTase SETD8; histone-lysine N-methyltransferase KMT5A; histone-lysine N-methyltransferase SETD8; lysine-specific methylase 5A; MGC117832; N-lysine methyltransferase KMT5A; N-lysine methyltransferase SETD8; PR-SET7; PR/SET domain-containing protein 07; PR/SET07; SET domain containing (lysine methyltransferase) 8; SET domain-containing protein 8; Setd8
Homo sapiens (human) : KMT5A (lysine methyltransferase 5A)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Kmt5a (lysine methyltransferase 5A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kmt5a (lysine methyltransferase 5A)
Pan paniscus (bonobo/pygmy chimpanzee) : KMT5A (lysine methyltransferase 5A)
Canis lupus familiaris (dog) : KMT5A (lysine methyltransferase 5A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kmt5a (lysine methyltransferase 5A)
Sus scrofa (pig) : KMT5A (lysine methyltransferase 5A)
Chlorocebus sabaeus (African green monkey) : KMT5A (lysine methyltransferase 5A)
Heterocephalus glaber (naked mole-rat) : Kmt5a (lysine methyltransferase 5A)
more info ...
Related Pseudogenes: Gm11424   Gm8590   Gm8770  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl5124,439,930 - 124,462,308 (+)EnsemblGRCm38mm10GRCm38
GRCm385124,439,930 - 124,462,311 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv375124,889,939 - 124,912,316 (+)NCBIGRCm37mm9NCBIm37
MGSCv365124,700,548 - 124,722,925 (+)NCBImm8
Celera5121,513,480 - 121,535,737 (+)NCBICelera
Cytogenetic Map5FNCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Kmt5a
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1332274
Created: 2005-02-01
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.