Isyna1 (myo-inositol 1-phosphate synthase A1) - Rat Genome Database
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Gene: Isyna1 (myo-inositol 1-phosphate synthase A1) Mus musculus
Analyze
Symbol: Isyna1
Name: myo-inositol 1-phosphate synthase A1
RGD ID: 1557022
MGI Page MGI
Description: Predicted to have inositol-3-phosphate synthase activity. Predicted to be involved in inositol biosynthetic process. Predicted to localize to cytoplasm. Is expressed in early conceptus and retina. Orthologous to human ISYNA1 (inositol-3-phosphate synthase 1); PARTICIPATES IN inositol metabolic pathway; inositol phosphate metabolic pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1300017C10Rik; AU018670; inositol-3-phosphate synthase 1; IPS 1; MI-1-P synthase; MIP synthase; myo-inositol-1-phosphate synthase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm4946  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39871,047,131 - 71,049,940 (+)NCBIGRCm39mm39
GRCm38870,594,481 - 70,597,290 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,594,373 - 70,597,290 (+)EnsemblGRCm38mm10GRCm38
MGSCv37873,118,380 - 73,121,189 (+)NCBIGRCm37mm9NCBIm37
MGSCv36873,523,470 - 73,526,279 (+)NCBImm8
Celera873,150,596 - 73,153,405 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-hydroxypropanoic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amiodarone  (ISO)
antirheumatic drug  (ISO)
arsenite(3-)  (EXP)
atrazine  (ISO)
benzbromarone  (ISO)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (EXP)
choline  (EXP)
chromium(6+)  (EXP)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (EXP)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
fipronil  (ISO)
flutamide  (ISO)
folic acid  (EXP)
furan  (EXP)
genistein  (ISO)
glafenine  (ISO)
indometacin  (ISO)
ketamine  (ISO)
L-ethionine  (ISO)
L-methionine  (EXP)
lipopolysaccharide  (EXP)
lovastatin  (EXP)
naphthalene  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nimesulide  (ISO)
omeprazole  (ISO)
p-toluidine  (ISO)
paracetamol  (EXP,ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
selenium atom  (ISO)
sodium fluoride  (EXP)
tamoxifen  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thimerosal  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
valdecoxib  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
warfarin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14610273   PMID:14613899   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16930510  
PMID:18675571   PMID:19188364   PMID:19423573   PMID:21677750   PMID:21873635   PMID:23341629   PMID:31040226   PMID:32325033  


Genomics

Comparative Map Data
Isyna1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39871,047,131 - 71,049,940 (+)NCBIGRCm39mm39
GRCm38870,594,481 - 70,597,290 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,594,373 - 70,597,290 (+)EnsemblGRCm38mm10GRCm38
MGSCv37873,118,380 - 73,121,189 (+)NCBIGRCm37mm9NCBIm37
MGSCv36873,523,470 - 73,526,279 (+)NCBImm8
Celera873,150,596 - 73,153,405 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
ISYNA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1918,434,388 - 18,438,167 (-)EnsemblGRCh38hg38GRCh38
GRCh381918,434,388 - 18,438,649 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371918,545,198 - 18,549,111 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361918,406,625 - 18,409,943 (-)NCBINCBI36hg18NCBI36
Celera1918,447,020 - 18,450,933 (-)NCBI
Cytogenetic Map19p13.11NCBI
HuRef1918,108,499 - 18,112,412 (-)NCBIHuRef
CHM1_11918,545,346 - 18,549,259 (-)NCBICHM1_1
Isyna1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01620,589,497 - 20,592,333 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,589,481 - 20,592,449 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01620,445,206 - 20,448,042 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41619,345,305 - 19,348,141 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11619,345,311 - 19,348,054 (-)NCBI
Celera1619,030,610 - 19,033,446 (-)NCBICelera
Cytogenetic Map16p14NCBI
Isyna1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555243,098,995 - 3,100,454 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555243,099,017 - 3,100,454 (+)NCBIChiLan1.0ChiLan1.0
ISYNA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11918,884,406 - 18,887,931 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1918,884,412 - 18,887,931 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01917,913,400 - 17,916,789 (-)NCBIMhudiblu_PPA_v0panPan3
ISYNA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2044,489,219 - 44,598,497 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12044,594,816 - 44,598,495 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Isyna1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365962,815,782 - 2,819,100 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ISYNA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl259,363,714 - 59,367,752 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1259,363,672 - 59,367,003 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ISYNA1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl616,905,472 - 16,910,030 (-)Ensembl
ChlSab1.1616,906,724 - 16,910,194 (-)NCBI
Isyna1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249081,658,512 - 1,661,507 (-)NCBI

Position Markers
RH126908  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38870,597,031 - 70,597,280UniSTSGRCm38
MGSCv37873,120,930 - 73,121,179UniSTSGRCm37
Celera873,153,146 - 73,153,395UniSTS
Cytogenetic Map8B3.3UniSTS
Whitehead/MRC_RH8743.88UniSTS
RH136244  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38870,597,067 - 70,597,267UniSTSGRCm38
MGSCv37873,120,966 - 73,121,166UniSTSGRCm37
Celera873,153,182 - 73,153,382UniSTS
Cytogenetic Map8B3.3UniSTS
RH129421  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38870,597,104 - 70,597,275UniSTSGRCm38
MGSCv37873,121,003 - 73,121,174UniSTSGRCm37
Celera873,153,219 - 73,153,390UniSTS
Cytogenetic Map8B3.3UniSTS
Isyna1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38870,595,821 - 70,596,121UniSTSGRCm38
MGSCv37873,119,720 - 73,120,020UniSTSGRCm37
Celera873,151,936 - 73,152,236UniSTS
Cytogenetic Map8B3.3UniSTS
cM Map8 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81472316071045600Mouse
1357811Orq3_movulation rate QTL 3 (mouse)Not determined83201654471287993Mouse
4141437W10q14_mweight 10 weeks QTL 14 (mouse)Not determined3201654471287993Mouse
4141172W6q9_mweight 6 weeks QTL 9 (mouse)Not determined3201654471287993Mouse
4140966Egq12_mearly growth QTL 12 (mouse)Not determined3201654471287993Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84429488078295025Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86826982782600347Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:132
Count of miRNA genes:129
Interacting mature miRNAs:132
Transcripts:ENSMUST00000019283
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000019283   ⟹   ENSMUSP00000019283
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,594,481 - 70,597,288 (+)Ensembl
RefSeq Acc Id: ENSMUST00000209285   ⟹   ENSMUSP00000147836
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,594,473 - 70,597,191 (+)Ensembl
RefSeq Acc Id: ENSMUST00000209751
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,595,055 - 70,595,854 (+)Ensembl
RefSeq Acc Id: ENSMUST00000210005   ⟹   ENSMUSP00000148077
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,594,481 - 70,597,290 (+)Ensembl
RefSeq Acc Id: ENSMUST00000210358
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,594,473 - 70,595,323 (+)Ensembl
RefSeq Acc Id: ENSMUST00000210878
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,594,490 - 70,597,288 (+)Ensembl
RefSeq Acc Id: ENSMUST00000211117   ⟹   ENSMUSP00000148101
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,594,373 - 70,595,163 (+)Ensembl
RefSeq Acc Id: ENSMUST00000211501   ⟹   ENSMUSP00000147430
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,594,727 - 70,595,757 (+)Ensembl
RefSeq Acc Id: ENSMUST00000211773
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,595,967 - 70,596,767 (+)Ensembl
RefSeq Acc Id: NM_023627   ⟹   NP_076116
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39871,047,131 - 71,049,940 (+)NCBI
GRCm38870,594,481 - 70,597,290 (+)ENTREZGENE
MGSCv37873,118,380 - 73,121,189 (+)RGD
Celera873,150,596 - 73,153,405 (+)RGD
cM Map8 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_076116   ⟸   NM_023627
- UniProtKB: Q9JHU9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000147430   ⟸   ENSMUST00000211501
RefSeq Acc Id: ENSMUSP00000148101   ⟸   ENSMUST00000211117
RefSeq Acc Id: ENSMUSP00000148077   ⟸   ENSMUST00000210005
RefSeq Acc Id: ENSMUSP00000019283   ⟸   ENSMUST00000019283
RefSeq Acc Id: ENSMUSP00000147836   ⟸   ENSMUST00000209285

Promoters
RGD ID:8667369
Promoter ID:EPDNEW_M11693
Type:initiation region
Name:Isyna1_1
Description:Mus musculus myo-inositol 1-phosphate synthase A1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38870,594,505 - 70,594,565EPDNEW
RGD ID:6843341
Promoter ID:MM_KWN:54721
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_023627,   UC009MAW.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36873,117,491 - 73,118,527 (+)MPROMDB
RGD ID:6848309
Promoter ID:MM_ACW:47842
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Lung
Transcripts:ISYNA1.CSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36873,119,221 - 73,120,212 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1919030 AgrOrtholog
Ensembl Genes ENSMUSG00000019139 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000019283 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000147430 UniProtKB/TrEMBL
  ENSMUSP00000147836 UniProtKB/TrEMBL
  ENSMUSP00000148077 UniProtKB/Swiss-Prot
  ENSMUSP00000148101 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000019283 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000209285 UniProtKB/TrEMBL
  ENSMUST00000210005 UniProtKB/Swiss-Prot
  ENSMUST00000211117 UniProtKB/TrEMBL
  ENSMUST00000211501 UniProtKB/TrEMBL
InterPro Myo-inos-1-P_Synthase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myo-inos-1-P_Synthase_GAPDH UniProtKB/Swiss-Prot
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:71780 UniProtKB/Swiss-Prot
MGD MGI:1919030 ENTREZGENE
NCBI Gene 71780 ENTREZGENE
PANTHER PTHR11510 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Inos-1-P_synth UniProtKB/Swiss-Prot
  NAD_binding_5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Isyna1 PhenoGen
PIRSF Myoinos-ppht_syn UniProtKB/Swiss-Prot
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.29357 ENTREZGENE
UniProt A0A1B0GR94_MOUSE UniProtKB/TrEMBL
  A0A1B0GS86_MOUSE UniProtKB/TrEMBL
  A0A1B0GSW6_MOUSE UniProtKB/TrEMBL
  INO1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE