Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Hspb1 (heat shock protein 1) Mus musculus
Symbol: Hspb1
Name: heat shock protein 1
Description: Exhibits protein kinase C binding activity and protein kinase C inhibitor activity. Involved in negative regulation of protein kinase activity; positive regulation of cytokine production; and regulation of intracellular signal transduction. Localizes to the Z disc; nucleus; and plasma membrane. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2F; distal hereditary motor neuropathy type 2B; pancreatic cancer; and sarcoma. Is expressed in several structures, including adipose tissue; alimentary system; brain; early conceptus; and genitourinary system. Orthologous to human HSPB1 (heat shock protein family B (small) member 1); PARTICIPATES IN Entamoebiasis pathway; mitogen activated protein kinase signaling pathway; vascular endothelial growth factor signaling pathway; INTERACTS WITH (+)-schisandrin B; (2,4,5-trichlorophenoxy)acetic acid; (S)-amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 27kDa; growth-related 25 kDa protein; heat shock 25 kDa protein; heat shock 27 kDa protein; heat shock 27kDa protein 1; heat shock protein beta-1; heat shock protein, 25 kDa; HSP 25; HSP 27; Hsp25; p25; truncated hsp25
Homo sapiens (human) : HSPB1 (heat shock protein family B (small) member 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Hspb1 (heat shock protein family B (small) member 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hspb1 (heat shock protein family B (small) member 1)
Pan paniscus (bonobo/pygmy chimpanzee) : HSPB1 (heat shock protein family B (small) member 1)
Canis lupus familiaris (dog) : HSPB1 (heat shock protein family B (small) member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hspb1 (heat shock protein family B (small) member 1)
Sus scrofa (pig) : HSPB1 (heat shock protein family B (small) member 1)
Heterocephalus glaber (naked mole-rat) : Hspb1 (heat shock protein family B (small) member 1)
more info ...
Related Pseudogenes: Hsp25-ps1  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl5135,887,919 - 135,889,563 (+)Ensembl
GRCm385135,887,919 - 135,889,563 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv375136,363,789 - 136,365,433 (+)NCBIGRCm37mm9NCBIm37
MGSCv365136,172,686 - 136,174,064 (+)NCBImm8
Celera5132,896,482 - 132,898,126 (+)NCBICelera
Cytogenetic Map5 G2NCBI
cM Map575.51NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Hspb1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732481
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-02-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.