Hspb1 (heat shock protein 1) - Rat Genome Database

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Gene: Hspb1 (heat shock protein 1) Mus musculus
Analyze
Symbol: Hspb1
Name: heat shock protein 1
RGD ID: 732481
MGI Page MGI
Description: Exhibits protein kinase C binding activity and protein kinase C inhibitor activity. Involved in negative regulation of protein kinase activity; positive regulation of cytokine production; and regulation of intracellular signal transduction. Localizes to Z disc; nucleus; and plasma membrane. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and limb long bone. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2F; distal hereditary motor neuropathy type 2B; pancreatic cancer; and sarcoma. Orthologous to human HSPB1 (heat shock protein family B (small) member 1); PARTICIPATES IN Entamoebiasis pathway; mitogen activated protein kinase signaling pathway; vascular endothelial growth factor signaling pathway; INTERACTS WITH (+)-schisandrin B; (2,4,5-trichlorophenoxy)acetic acid; (S)-amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 27kDa; growth-related 25 kDa protein; heat shock 25 kDa protein; heat shock 27 kDa protein; heat shock 27kDa protein 1; heat shock protein beta-1; heat shock protein, 25 kDa; Hsp; HSP 25; HSP 27; Hsp25; p25; truncated hsp25
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Hsp25-ps1  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395135,916,773 - 135,918,417 (+)NCBIGRCm39mm39
GRCm39 Ensembl5135,916,773 - 135,918,417 (+)Ensembl
GRCm385135,887,919 - 135,889,563 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5135,887,919 - 135,889,563 (+)EnsemblGRCm38mm10GRCm38
MGSCv375136,363,789 - 136,365,433 (+)NCBIGRCm37mm9NCBIm37
MGSCv365136,172,686 - 136,174,064 (+)NCBImm8
Celera5132,896,482 - 132,898,126 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map575.51NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-lariciresinol  (ISO)
(+)-pilocarpine  (ISO)
(+)-schisandrin B  (EXP,ISO)
(-)-lariciresinol  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (EXP)
(S)-amphetamine  (EXP)
1,1-dichloroethene  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1,3,5-trinitro-1,3,5-triazinane  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-Hydroxypyrene  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
1H-pyrazole  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (ISO)
2-amino-4,6-dinitrotoluene  (ISO)
2-methylcholine  (ISO)
2-nitrofluorene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3'-diindolylmethane  (ISO)
3,3'-Thiobispropanoic acid  (ISO)
3-Hydroxybenzo[a]pyrene  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-amino-2,6-dinitrotoluene  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitroquinoline N-oxide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-formyltetrahydrofolic acid  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
aldrin  (EXP)
all-trans-retinoic acid  (EXP,ISO)
alpha-hexachlorocyclohexane  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
amphibole asbestos  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
arecoline  (EXP)
argipressin  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
ATP  (EXP)
atrazine  (ISO)
Aurin  (ISO)
azetidinecarboxylic acid  (ISO)
benomyl  (ISO)
benzo[a]pyrene  (EXP,ISO)
bexarotene  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A2  (ISO)
bortezomib  (ISO)
bucladesine  (ISO)
bufalin  (ISO)
butan-1-ol  (ISO)
butyric acid  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
capsaicin  (ISO)
captan  (EXP)
carbon nanotube  (EXP)
carboplatin  (ISO)
chlorogenic acid  (ISO)
chlorohydrocarbon  (ISO)
chloropicrin  (ISO)
chloroprene  (EXP)
chromium atom  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (EXP,ISO)
corticosterone  (ISO)
CU-O LINKAGE  (ISO)
cumene hydroperoxide  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
D-glucose  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (EXP)
diclofenac  (EXP)
Dienochlor  (ISO)
diethylstilbestrol  (ISO)
dihydroxyacetone  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
disulfiram  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
ethanol  (EXP,ISO)
fenofibrate  (EXP,ISO)
filipin III  (EXP)
finasteride  (ISO)
flutamide  (ISO)
folpet  (EXP)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP,ISO)
genistein  (EXP)
glucose  (ISO)
glutathione  (ISO)
gold atom  (EXP,ISO)
gold(0)  (EXP,ISO)
graphite  (ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (EXP,ISO)
imidacloprid  (ISO)
indometacin  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isobutanol  (ISO)
isoprenaline  (ISO)
kojic acid  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (ISO)
lead(II) chloride  (ISO)
leflunomide  (ISO)
linalool  (ISO)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (ISO)
LY294002  (ISO)
menadione  (ISO)
mercury dichloride  (ISO)
metacetamol  (EXP)
methamphetamine  (EXP,ISO)
methapyrilene  (ISO)
methimazole  (ISO)
methotrexate  (EXP,ISO)
methoxyacetic acid  (ISO)
methyl beta-cyclodextrin  (EXP)
methylglyoxal  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (EXP,ISO)
Monobutylphthalate  (EXP,ISO)
monocrotaline  (EXP)
monosodium L-glutamate  (ISO)
morphine  (ISO)
motexafin gadolinium  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-BUTYL-11-[(7R,8R,9S,13S,14S,17S)-3,17-DIHYDROXY-13-METHYL-7,8,9,11,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHREN-7-YL]-N-METHYLUNDECANAMIDE  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methylformamide  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
N-nitrosomorpholine  (ISO)
naphthalene  (EXP)
nefazodone  (ISO)
neodymium atom  (ISO)
nickel atom  (ISO)
nicotinic acid  (ISO)
nimesulide  (ISO)
Nonylphenol  (ISO)
O-acetyl-L-carnitine  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
Osajin  (ISO)
oxaliplatin  (ISO)
oxidopamine  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentobarbital  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (EXP)
phenethyl caffeate  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phenytoin  (EXP)
PhIP  (ISO)
phlorizin  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP,ISO)
Pomiferin  (ISO)
potassium dichromate  (ISO)
potassium hydroxide  (ISO)
progesterone  (ISO)
propiconazole  (EXP)
puerarin  (ISO)
quercetin  (EXP,ISO)
reactive oxygen species  (EXP)
resveratrol  (ISO)
rifampicin  (EXP)
Rosavin  (ISO)
rotenone  (EXP,ISO)
SB 203580  (EXP,ISO)
SCH 23390  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (ISO)
streptozocin  (ISO)
sunitinib  (ISO)
superoxide  (EXP)
tamoxifen  (EXP,ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (EXP)
thimerosal  (ISO)
thioacetamide  (ISO)
thiopental  (ISO)
thiostrepton  (ISO)
Tiron  (EXP)
titanium dioxide  (EXP,ISO)
topotecan  (ISO)
trichloroethene  (EXP,ISO)
troglitazone  (EXP)
tungsten  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
vinclozolin  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zearalenone  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
anterograde axonal protein transport  (ISO)
cellular response to butyrate  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to interleukin-11  (ISO)
cellular response to vascular endothelial growth factor stimulus  (ISO)
chaperone-mediated protein folding  (ISO)
female pregnancy  (ISO)
intracellular signal transduction  (ISO)
negative regulation of apoptotic signaling pathway  (IDA)
negative regulation of oxidative stress-induced cell death  (ISO)
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  (IDA)
negative regulation of protein kinase activity  (IDA)
negative regulation of regulatory T cell differentiation  (ISO)
platelet aggregation  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of endothelial cell chemotaxis  (ISO)
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway  (ISO)
positive regulation of interleukin-1 beta production  (IDA)
positive regulation of neuron projection development  (ISO)
positive regulation of tumor necrosis factor production  (IDA)
regulation of I-kappaB kinase/NF-kappaB signaling  (IDA)
regulation of protein phosphorylation  (ISO)
response to angiotensin  (ISO)
response to ischemia  (ISO)
response to muscle stretch  (ISO)
response to unfolded protein  (NAS)
response to virus  (ISO)
retina homeostasis  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Bechtold DA and Brown IR, Neurochem Res 2003 Aug;28(8):1163-73.
2. Filipcik P, etal., Biochim Biophys Acta. 2015 Jul;1852(7):1219-29. doi: 10.1016/j.bbadis.2015.03.003. Epub 2015 Mar 12.
3. Fujisawa K, etal., Exp Toxicol Pathol. 2013 Jul;65(5):469-76. doi: 10.1016/j.etp.2012.02.001. Epub 2012 Mar 12.
4. Gong Y, etal., Stroke. 2004 Nov;35(11):2571-5. Epub 2004 Oct 7.
5. He Y, etal., Biosci Rep. 2018 Nov 7;38(6). pii: BSR20180895. doi: 10.1042/BSR20180895. Print 2018 Dec 21.
6. Heinrich JC, etal., J Cancer Res Clin Oncol. 2011 Sep;137(9):1349-61. doi: 10.1007/s00432-011-1005-1. Epub 2011 Jul 22.
7. Imura T, etal., J Neurosci. 1999 Nov 15;19(22):9768-79.
8. Joachim SC, etal., Invest Ophthalmol Vis Sci. 2011 Jun 1;52(6):3468-74. doi: 10.1167/iovs.10-5763.
9. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
10. Koh TJ and Escobedo J, Am J Physiol Cell Physiol 2004 Mar;286(3):C713-22. Epub 2003 Nov 19.
11. MGD data from the GO Consortium
12. Neidhardt L, etal., Mech Dev 2000 Nov;98(1-2):77-94.
13. OMIM Disease Annotation Pipeline
14. Pipeline to import KEGG annotations from KEGG into RGD
15. RGD automated import pipeline
16. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. RGD automated import pipeline for gene-chemical interactions
18. Sanchez-Nino MD, etal., Lab Invest. 2012 Jan;92(1):32-45. doi: 10.1038/labinvest.2011.138. Epub 2011 Sep 19.
19. Sanz O, etal., Glia. 2001 Dec;36(3):259-70.
20. Sedlackova L, etal., Scand J Rheumatol. 2011;40(5):354-7. doi: 10.3109/03009742.2011.552522. Epub 2011 Mar 21.
21. Tachibana T, etal., Neurosci Lett. 2002 Jul 19;327(2):133-7.
22. Tadros SF, etal., PLoS One. 2014 Feb 28;9(2):e90279. doi: 10.1371/journal.pone.0090279. eCollection 2014.
Additional References at PubMed
PMID:1860870   PMID:2645135   PMID:8093612   PMID:8132504   PMID:8425893   PMID:8514193   PMID:8514194   PMID:9122205   PMID:9344682   PMID:9880236   PMID:10101046   PMID:10221453  
PMID:10349636   PMID:10383393   PMID:10545106   PMID:10631312   PMID:10751411   PMID:10859165   PMID:10922068   PMID:11032181   PMID:11042159   PMID:11076861   PMID:11086286   PMID:11304494  
PMID:11331528   PMID:11774370   PMID:11892982   PMID:12038984   PMID:12385642   PMID:12466851   PMID:12477932   PMID:12592567   PMID:12637495   PMID:12730876   PMID:12740362   PMID:12748967  
PMID:12930754   PMID:14578350   PMID:14610273   PMID:14662766   PMID:14975446   PMID:15010265   PMID:15122254   PMID:15155620   PMID:15170228   PMID:15272315   PMID:15350538   PMID:15454285  
PMID:15472464   PMID:15489334   PMID:15509539   PMID:15538386   PMID:15593327   PMID:15649839   PMID:15687248   PMID:15706091   PMID:15731106   PMID:16127699   PMID:16141072   PMID:16141073  
PMID:16160063   PMID:16306130   PMID:16333981   PMID:16554407   PMID:16571921   PMID:16624816   PMID:16638982   PMID:16774995   PMID:16840785   PMID:17030443   PMID:17071584   PMID:17177285  
PMID:17439945   PMID:17616692   PMID:17661394   PMID:17881652   PMID:18384969   PMID:18927263   PMID:19021764   PMID:19100870   PMID:19225803   PMID:19240800   PMID:19726550   PMID:20196617  
PMID:20304146   PMID:20368287   PMID:20394049   PMID:21427224   PMID:21431469   PMID:21436445   PMID:21565611   PMID:21589869   PMID:21731611   PMID:21975426   PMID:22068623   PMID:22140065  
PMID:22185976   PMID:22350794   PMID:22971995   PMID:23979601   PMID:24141048   PMID:24143227   PMID:24194600   PMID:24465581   PMID:24586549   PMID:25446099   PMID:25736854   PMID:26026081  
PMID:26141737   PMID:26514267   PMID:26744531   PMID:26936078   PMID:27152617   PMID:27418600   PMID:27512988   PMID:27626380   PMID:27928820   PMID:28077174   PMID:28378742   PMID:28700664  
PMID:28768826   PMID:28797631   PMID:28902366   PMID:29133339   PMID:29164525   PMID:29459677   PMID:29792912   PMID:29982352   PMID:30171788   PMID:30578393   PMID:30595499   PMID:30833597  
PMID:30964709   PMID:31509576   PMID:32325033   PMID:32379417   PMID:32420594  


Genomics

Comparative Map Data
Hspb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395135,916,773 - 135,918,417 (+)NCBIGRCm39mm39
GRCm39 Ensembl5135,916,773 - 135,918,417 (+)Ensembl
GRCm385135,887,919 - 135,889,563 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5135,887,919 - 135,889,563 (+)EnsemblGRCm38mm10GRCm38
MGSCv375136,363,789 - 136,365,433 (+)NCBIGRCm37mm9NCBIm37
MGSCv365136,172,686 - 136,174,064 (+)NCBImm8
Celera5132,896,482 - 132,898,126 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map575.51NCBI
HSPB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl776,302,673 - 76,304,295 (+)EnsemblGRCh38hg38GRCh38
GRCh38776,302,673 - 76,304,292 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37775,931,990 - 75,933,609 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36775,769,859 - 75,771,548 (+)NCBINCBI36hg18NCBI36
Build 34775,576,573 - 75,578,263NCBI
Celera770,800,374 - 70,802,113 (+)NCBI
Cytogenetic Map7q11.23NCBI
HuRef771,018,196 - 71,019,935 (+)NCBIHuRef
CHM1_1775,861,968 - 75,863,707 (+)NCBICHM1_1
CRA_TCAGchr7v2775,264,939 - 75,266,678 (+)NCBI
Hspb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21220,794,014 - 20,795,675 (-)NCBI
Rnor_6.0 Ensembl1223,839,399 - 23,841,049 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01223,839,390 - 23,841,051 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01225,837,102 - 25,838,663 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41221,911,223 - 21,912,784 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11221,898,486 - 21,900,048 (-)NCBI
Celera1222,557,404 - 22,559,067 (-)NCBICelera
Cytogenetic Map12q12NCBI
Hspb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049558447,790 - 10,004 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049558448,094 - 9,565 (+)NCBIChiLan1.0ChiLan1.0
HSPB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1782,751,385 - 82,753,109 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl782,751,523 - 82,752,984 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0767,716,021 - 67,717,762 (-)NCBIMhudiblu_PPA_v0panPan3
HSPB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.167,487,164 - 7,488,576 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl67,487,250 - 7,488,576 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha69,182,749 - 9,184,173 (+)NCBI
ROS_Cfam_1.067,307,626 - 7,309,048 (+)NCBI
UMICH_Zoey_3.167,276,667 - 7,278,079 (+)NCBI
UNSW_CanFamBas_1.067,239,649 - 7,241,061 (+)NCBI
UU_Cfam_GSD_1.067,403,114 - 7,404,545 (+)NCBI
Hspb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344131,924,637 - 131,926,212 (+)NCBI
SpeTri2.0NW_0049365432,110,351 - 2,111,896 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSPB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl310,037,936 - 10,039,915 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1310,038,074 - 10,039,441 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.239,925,991 - 9,927,359 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HSPB1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12810,442,530 - 10,443,804 (+)NCBI
ChlSab1.1 Ensembl2810,442,398 - 10,443,855 (+)Ensembl
Hspb1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474014,940,161 - 14,941,561 (+)NCBI

Position Markers
Hspb1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381345,078,636 - 45,079,043UniSTSGRCm38
GRCm385135,888,143 - 135,889,292UniSTSGRCm38
MGSCv371345,173,874 - 45,174,073UniSTSGRCm37
Celera5132,896,706 - 132,897,855UniSTS
Celera1346,147,078 - 46,147,485UniSTS
Cytogenetic Map5G2UniSTS
Cytogenetic Map13A5UniSTS
cM Map576.0UniSTS
Hsp25  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381345,078,491 - 45,078,715UniSTSGRCm38
GRCm385135,889,085 - 135,889,437UniSTSGRCm38
MGSCv375136,364,955 - 136,365,307UniSTSGRCm37
MGSCv371345,173,860 - 45,174,084UniSTSGRCm37
Celera5132,897,648 - 132,898,000UniSTS
Celera1346,146,933 - 46,147,157UniSTS
Cytogenetic Map5G2UniSTS
Cytogenetic Map13A5UniSTS
cM Map576.0UniSTS
Hspb1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381345,078,505 - 45,078,704UniSTSGRCm38
MGSCv371345,173,874 - 45,174,073UniSTSGRCm37
Celera1346,146,947 - 46,147,146UniSTS
Cytogenetic Map13A5UniSTS
Cytogenetic Map5G2UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526236236138457140Mouse
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572700000140000000Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589271017146851125Mouse
14746986Manh58_mmandible shape 58 (mouse)5102308218136308218Mouse
11532736Sluc33b_msusceptibility to lung cancer 33b (mouse)5102806972136807131Mouse
10412202Bbaa26_mB.burgdorferi-associated arthritis 26 (mouse)Not determined5104435822138557193Mouse
10412239Alpq7_malcohol preference QTL 7 (mouse)Not determined5104567876138567876Mouse
4142473Chlq11_mcirculating hormone level QTL 11 (mouse)Not determined5107829235141829348Mouse
10043890Trigq4_mtriglyceride QTL 4 (mouse)Not determined5107829235141829348Mouse
13464243Ahl20_mage related hearing loss, early onset 20 (mouse)5107829235141829348Mouse
10412197Bbaa25_mB.burgdorferi-associated arthritis 25 (mouse)Not determined5109090176143090317Mouse
13464251Ahl21_mage related hearing loss, early onset 21 (mouse)5109090176143090317Mouse
1301543Hypch_mhypercholesterolemia (mouse)Not determined5109090758139133150Mouse
1300913Bwefm_mbody weight females and males day 10 (mouse)Not determined5109362284143362395Mouse
1301102Cia14_mcollagen induced arthritis 14 (mouse)Not determined5113172519138557193Mouse
1300827Cora1_mcorrelation in cytokine production 1 (mouse)Not determined5115128044149128176Mouse
1301226Bbaa2_mB.burgdorferi-associated arthritis 2 (mouse)Not determined5115128044149128176Mouse
1301857Bglq14_mbody growth late QTL 14 (mouse)Not determined5118920110151834684Mouse
10412191Bbaa24_mB.burgdorferi-associated arthritis 24 (mouse)Not determined5119806972141714711Mouse
4141081Nidd7k_mNidd7 on KK-A (mouse)Not determined119806972149423861Mouse
11528552Scram1_mspinal cord resistance to astrocytoma modifier 1 (mouse)5121457140151834684Mouse
1301986Bpq4_mblood pressure QTL 4 (mouse)Not determined5121556974151834684Mouse
1302079Lbw3_mlupus NZB x NZW 3 (mouse)Not determined5124714580151834684Mouse
1301715Elmaz2_melevated maze behavior 2 (mouse)Not determined5125101165141714711Mouse
1301363Pbwg13_mpostnatal body weight growth 13 (mouse)Not determined5125147702151834684Mouse
4141218Ath24_matherosclerosis 24 (mouse)Not determined129583274151834684Mouse
12880406Jcdq2_mjoint cartilage degeneration QTL 2 (mouse)5129851021151834684Mouse
11049557Lmr26_mleishmaniasis resistance 26 (mouse)5134002093151834684Mouse
14700793Mencq4_mmeniscus calcification QTL 4 (mouse)5135867000136190000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:353
Count of miRNA genes:262
Interacting mature miRNAs:280
Transcripts:ENSMUST00000005077, ENSMUST00000111155
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_013560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA013886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC084162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF047377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF047378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH001918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK003119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK010663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AV458710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC018257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC090388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC099463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L07577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U03560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U03561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U03562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X14686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X14687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000005077   ⟹   ENSMUSP00000005077
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl5135,887,919 - 135,889,563 (+)Ensembl
RefSeq Acc Id: ENSMUST00000111155   ⟹   ENSMUSP00000106785
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl5135,888,018 - 135,889,561 (+)Ensembl
RefSeq Acc Id: NM_013560   ⟹   NP_038588
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395135,916,773 - 135,918,417 (+)NCBI
GRCm385135,887,919 - 135,889,563 (+)ENTREZGENE
MGSCv375136,363,789 - 136,365,433 (+)RGD
Celera5132,896,482 - 132,898,126 (+)RGD
cM Map5 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_038588   ⟸   NM_013560
- UniProtKB: P14602 (UniProtKB/Swiss-Prot),   Q545F4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000106785   ⟸   ENSMUST00000111155
RefSeq Acc Id: ENSMUSP00000005077   ⟸   ENSMUST00000005077
Protein Domains
sHSP

Promoters
RGD ID:6888340
Promoter ID:EPDNEW_M7621
Type:initiation region
Name:Hspb1_1
Description:Mus musculus heat shock protein 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385135,888,002 - 135,888,062EPDNEW
RGD ID:6837724
Promoter ID:MM_KWN:44383
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000111155,   ENSMUST00000111156,   NM_013560,   UC008ZZD.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365136,363,701 - 136,364,201 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96240 AgrOrtholog
Ensembl Genes ENSMUSG00000004951 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000005077 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000106785 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000005077 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000111155 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.790 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro A-crystallin/Hsp20_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ACD_HspB1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Alpha-crystallin/HSP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP20-like_chaperone UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:15507 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:96240 ENTREZGENE
NCBI Gene 15507 ENTREZGENE
PANTHER PTHR45640 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HSP20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hspb1 PhenoGen
PRINTS ACRYSTALLIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SHSP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49764 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3YZ06_MOUSE UniProtKB/TrEMBL
  HSPB1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q545F4 ENTREZGENE, UniProtKB/TrEMBL
  Q9Z2L2_MOUSE UniProtKB/TrEMBL
  Q9Z2L3_MOUSE UniProtKB/TrEMBL