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Gene: Hspb1 (heat shock protein 1) Mus musculus
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Symbol: Hspb1
Name: heat shock protein 1
Description: Exhibits protein kinase C binding activity and protein kinase C inhibitor activity. Involved in negative regulation of protein kinase activity; positive regulation of cytokine production; and regulation of intracellular signal transduction. Localizes to the Z disc; nucleus; and plasma membrane. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2F; distal hereditary motor neuropathy type 2B; pancreatic cancer; and sarcoma. Is expressed in several structures, including adipose tissue; alimentary system; brain; early conceptus; and genitourinary system. Orthologous to human HSPB1 (heat shock protein family B (small) member 1); PARTICIPATES IN Entamoebiasis pathway; mitogen activated protein kinase signaling pathway; vascular endothelial growth factor signaling pathway; INTERACTS WITH (+)-schisandrin B; (2,4,5-trichlorophenoxy)acetic acid; (S)-amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 27kDa; growth-related 25 kDa protein; heat shock 25 kDa protein; heat shock 27 kDa protein; heat shock 27kDa protein 1; heat shock protein beta-1; heat shock protein, 25 kDa; HSP 25; HSP 27; Hsp25; p25; truncated hsp25
Orthologs:
Homo sapiens (human) : HSPB1 (heat shock protein family B (small) member 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Hspb1 (heat shock protein family B (small) member 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hspb1 (heat shock protein family B (small) member 1)
Pan paniscus (bonobo/pygmy chimpanzee) : HSPB1 (heat shock protein family B (small) member 1)
Canis lupus familiaris (dog) : HSPB1 (heat shock protein family B (small) member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hspb1 (heat shock protein family B (small) member 1)
Sus scrofa (pig) : HSPB1 (heat shock protein family B (small) member 1)
Heterocephalus glaber (naked mole-rat) : Hspb1 (heat shock protein family B (small) member 1)
more info ...
Related Pseudogenes: Hsp25-ps1  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl5135,887,919 - 135,889,563 (+)Ensembl
GRCm385135,887,919 - 135,889,563 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv375136,363,789 - 136,365,433 (+)NCBIGRCm37mm9NCBIm37
MGSCv365136,172,686 - 136,174,064 (+)NCBImm8
Celera5132,896,482 - 132,898,126 (+)NCBICelera
Cytogenetic Map5 G2NCBI
cM Map575.51NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Hspb1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732481
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-02-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.