Mdk (midkine) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Mdk (midkine) Mus musculus
Analyze
Symbol: Mdk
Name: midkine
RGD ID: 69143
MGI Page MGI
Description: Enables chondroitin sulfate binding activity and heparin binding activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of cell adhesion; and positive regulation of leukocyte migration. Predicted to be located in cell projection. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study schizophrenia. Human ortholog(s) of this gene implicated in brain ischemia. Orthologous to human MDK (midkine).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Mek; MK; retinoic acid-induced differentiation factor
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Mdk-ps1  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39291,760,149 - 91,762,348 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl291,760,150 - 91,762,642 (-)EnsemblGRCm39 Ensembl
GRCm38291,929,805 - 91,932,297 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl291,929,805 - 91,932,297 (-)EnsemblGRCm38mm10GRCm38
MGSCv37291,769,978 - 91,772,439 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36291,730,660 - 91,733,121 (-)NCBIMGSCv36mm8
Celera293,320,223 - 93,322,680 (-)NCBICelera
Cytogenetic Map2E1NCBI
cM Map250.63NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-naringenin  (ISO)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (ISO)
amphetamine  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
Azoxymethane  (EXP)
azoxystrobin  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
beta-lapachone  (ISO)
bicalutamide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
butan-1-ol  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
carbon nanotube  (EXP)
carmustine  (ISO)
chlorpyrifos  (ISO)
choline  (EXP)
chondroitin sulfate  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
D-glucose  (EXP)
dermatan sulfate  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (EXP)
dieldrin  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
enzalutamide  (ISO)
ethanol  (EXP)
fenamidone  (EXP)
fenpyroximate  (ISO)
folic acid  (EXP)
furosemide  (ISO)
gefitinib  (EXP)
genistein  (ISO)
glucose  (EXP)
glycidol  (ISO)
gossypol  (ISO)
hexane  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (EXP)
lead diacetate  (ISO)
mitomycin C  (ISO)
monosodium L-glutamate  (EXP)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
Nutlin-3  (ISO)
O-methyleugenol  (ISO)
oxaliplatin  (ISO)
paraquat  (ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenytoin  (ISO)
PhIP  (ISO)
picoxystrobin  (ISO)
piroxicam  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
Rhein  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (EXP)
tebufenpyrad  (ISO)
temozolomide  (ISO)
thifluzamide  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trichloroethene  (ISO)
triptonide  (EXP)
troglitazone  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
zearalenone  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (ISO,ISS)
behavioral fear response  (IMP)
cell migration  (ISO)
cerebellar granular layer development  (IMP)
cerebral cortex development  (IEP)
cytoskeleton organization  (IMP)
defecation  (IMP)
dentate gyrus development  (IEP)
estrous cycle  (IMP)
glial cell projection elongation  (IDA)
hippocampus development  (IMP)
intracellular signal transduction  (ISO,ISS)
leukocyte chemotaxis involved in inflammatory response  (IMP,ISO,ISS)
negative regulation of canonical Wnt signaling pathway  (IMP)
negative regulation of cardiac muscle cell apoptotic process  (IMP,ISO,ISS)
negative regulation of cell adhesion  (IDA)
negative regulation of epithelial cell apoptotic process  (IMP)
negative regulation of inflammatory response to wounding  (IMP)
negative regulation of neuron apoptotic process  (IMP,ISO)
negative regulation of ossification  (IMP)
negative regulation of regulatory T cell differentiation  (ISO,ISS)
oogenesis  (IMP)
positive regulation of artery morphogenesis  (IMP)
positive regulation of blood vessel branching  (ISO,ISS)
positive regulation of cartilage development  (IMP)
positive regulation of cell adhesion  (ISO,ISS)
positive regulation of cell division  (IEA)
positive regulation of cell migration  (ISO,ISS)
positive regulation of DNA-templated transcription  (IMP)
positive regulation of epithelial to mesenchymal transition  (ISO,ISS)
positive regulation of hepatocyte proliferation  (IMP)
positive regulation of inflammatory response  (ISO,ISS)
positive regulation of inflammatory response to wounding  (IMP)
positive regulation of interleukin-12 production  (ISO,ISS)
positive regulation of keratinocyte proliferation  (ISO,ISS)
positive regulation of leukocyte adhesion to vascular endothelial cell  (IMP)
positive regulation of leukocyte cell-cell adhesion  (ISO,ISS)
positive regulation of leukocyte chemotaxis  (IMP)
positive regulation of macrophage chemotaxis  (IMP,ISO,ISS)
positive regulation of neural precursor cell proliferation  (IMP)
positive regulation of neuron migration  (ISO,ISS)
positive regulation of neuron projection development  (ISO,ISS)
positive regulation of neutrophil chemotaxis  (IMP)
positive regulation of neutrophil extravasation  (IMP)
positive regulation of oligodendrocyte differentiation  (ISO,ISS)
positive regulation of smooth muscle cell chemotaxis  (ISO,ISS)
positive regulation of substrate adhesion-dependent cell spreading  (IMP)
positive regulation of T cell differentiation  (IMP)
positive regulation of vascular endothelial cell proliferation  (IMP)
regulation of behavior  (IMP)
regulation of bone remodeling  (IMP)
regulation of chondrocyte differentiation  (IMP)
response to auditory stimulus  (IMP)
response to glucocorticoid  (ISO)
response to hormone  (ISO)
response to wounding  (IDA,ISO)
response to xenobiotic stimulus  (ISO)
short-term memory  (IMP)
T cell activation involved in immune response  (IMP)
tissue regeneration  (IMP)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal circulating enzyme level  (IAGP)
abnormal colon morphology  (IAGP)
abnormal dentate gyrus morphology  (IAGP)
abnormal digestive system morphology  (IAGP)
abnormal estrous cycle  (IAGP)
abnormal hearing physiology  (IAGP)
abnormal hippocampus development  (IAGP)
abnormal intestinal mucosa morphology  (IAGP)
abnormal learning/memory/conditioning  (IAGP)
abnormal macrophage chemotaxis  (IAGP)
abnormal social investigation  (IAGP)
abnormal vagina epithelium morphology  (IAGP)
abnormal vagina orifice morphology  (IAGP)
abnormal vascular endothelial cell morphology  (IAGP)
abnormal wound healing  (IAGP)
constricted vagina orifice  (IAGP)
decreased body weight  (IAGP)
decreased dopamine level  (IAGP)
decreased hepatocyte number  (IAGP)
decreased liver weight  (IAGP)
decreased locomotor activity  (IAGP)
decreased macrophage cell number  (IAGP)
decreased mature ovarian follicle number  (IAGP)
decreased mean corpuscular volume  (IEA)
decreased prepulse inhibition  (IAGP)
decreased superovulation rate  (IAGP)
female infertility  (IAGP)
impaired neutrophil chemotaxis  (IAGP)
impaired ovarian folliculogenesis  (IAGP)
impaired righting response  (IEA)
increased anxiety-related response  (IAGP)
increased circulating chloride level  (IEA)
increased circulating cholesterol level  (IEA)
increased circulating HDL cholesterol level  (IEA)
increased circulating sodium level  (IEA)
kidney failure  (IAGP)
preweaning lethality, incomplete penetrance  (IAGP)
prolonged diestrus  (IAGP)
prolonged proestrus  (IAGP)
short estrus  (IAGP)
slow postnatal weight gain  (IAGP)
small ovary  (IAGP)
tubular nephritis  (IAGP)
vagina atrophy  (IAGP)
vaginal septum  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Midkine and retinoic acid reduce cerebral infarction induced by middle cerebral artery ligation in rats. Harvey BK, etal., Neurosci Lett. 2004 Oct 14;369(2):138-41.
2. Possible implication of midkine in the development of endometriosis. Hirota Y, etal., Hum Reprod. 2005 Apr;20(4):1084-9. Epub 2005 Feb 25.
3. Neointima formation in a restenosis model is suppressed in midkine-deficient mice. Horiba M, etal., J Clin Invest 2000 Feb;105(4):489-95.
4. Basic FGF and FGF receptor 1 are expressed in microglia during experimental autoimmune encephalomyelitis: temporally distinct expression of midkine and pleiotrophin. Liu X, etal., Glia. 1998 Dec;24(4):390-7.
5. Midkine, a heparin-binding growth factor, is fundamentally involved in the pathogenesis of rheumatoid arthritis. Maruyama K, etal., Arthritis Rheum. 2004 May;50(5):1420-9.
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. MGD IEA MGD IEA
8. Myocardial infarction induces expression of midkine, a heparin-binding growth factor with reparative activity. Obama H, etal., Anticancer Res. 1998 Jan-Feb;18(1A):145-52.
9. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
10. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
11. Haptotactic migration induced by midkine. Involvement of protein-tyrosine phosphatase zeta. Mitogen-activated protein kinase, and phosphatidylinositol 3-kinase. Qi M, etal., J Biol Chem. 2001 May 11;276(19):15868-75.
12. Mouse MP Annotation Import Pipeline RGD automated import pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Midkine antisense oligodeoxyribonucleotide inhibits renal damage induced by ischemic reperfusion. Sato W, etal., Kidney Int. 2005 Apr;67(4):1330-9.
16. Alteration of midkine expression in the ischemic brain of humans. Wada M, etal., J Neurol Sci. 2002 Aug 15;200(1-2):67-73.
Additional References at PubMed
PMID:1347477   PMID:1450517   PMID:1550576   PMID:1689730   PMID:2025291   PMID:2345177   PMID:2355021   PMID:3355557   PMID:7488150   PMID:7698992   PMID:7829063   PMID:7835084  
PMID:7867507   PMID:7982887   PMID:8281012   PMID:8318736   PMID:8358169   PMID:8377224   PMID:8507561   PMID:8535077   PMID:8537330   PMID:8827451   PMID:8921396   PMID:8950987  
PMID:8978061   PMID:9089390   PMID:9434962   PMID:9449675   PMID:9501026   PMID:9572580   PMID:10096022   PMID:10349636   PMID:10830434   PMID:10958641   PMID:10978312   PMID:11042159  
PMID:11076861   PMID:11133157   PMID:11217851   PMID:11518254   PMID:11544339   PMID:11731432   PMID:12122009   PMID:12207052   PMID:12215536   PMID:12386288   PMID:12477932   PMID:12495930  
PMID:12761850   PMID:14610273   PMID:14681479   PMID:14708942   PMID:14970216   PMID:15031101   PMID:15047154   PMID:15060137   PMID:15197188   PMID:15482347   PMID:15489334   PMID:15509530  
PMID:15582152   PMID:15604097   PMID:15632069   PMID:15645444   PMID:15703188   PMID:15817462   PMID:15823575   PMID:15878231   PMID:15979460   PMID:15985215   PMID:16141072   PMID:16141073  
PMID:16400005   PMID:16537572   PMID:16602821   PMID:16619002   PMID:16643958   PMID:16683987   PMID:16901907   PMID:17015789   PMID:17062627   PMID:17121547   PMID:17204554   PMID:17230638  
PMID:17438133   PMID:17496152   PMID:17607302   PMID:17901120   PMID:18287559   PMID:18319343   PMID:18340008   PMID:18554416   PMID:18582856   PMID:18799693   PMID:18973680   PMID:19060126  
PMID:19217924   PMID:19303107   PMID:19409372   PMID:19437545   PMID:19451697   PMID:19521555   PMID:19535098   PMID:20200993   PMID:20346117   PMID:20442752   PMID:20685737   PMID:21041952  
PMID:21048029   PMID:21089377   PMID:21185956   PMID:21267068   PMID:21301897   PMID:21704677   PMID:21862448   PMID:21873635   PMID:22130515   PMID:22140262   PMID:22323540   PMID:22342918  
PMID:22682244   PMID:22707563   PMID:22871361   PMID:22998872   PMID:23201132   PMID:23243020   PMID:23459167   PMID:23537525   PMID:23640455   PMID:23673330   PMID:23891830   PMID:23891929  
PMID:23895415   PMID:23976985   PMID:24055194   PMID:24083030   PMID:24096156   PMID:24102259   PMID:24106831   PMID:24116381   PMID:24125182   PMID:24194600   PMID:24238062   PMID:24291499  
PMID:24458438   PMID:24516630   PMID:25035421   PMID:25149366   PMID:25377079   PMID:25551381   PMID:26206265   PMID:26975703   PMID:27626380   PMID:27992669   PMID:28044069   PMID:28183532  
PMID:28398003   PMID:28650075   PMID:28658220   PMID:28671696   PMID:28700664   PMID:28705898   PMID:29031500   PMID:29061398   PMID:29233575   PMID:29438518   PMID:30647120   PMID:30825522  
PMID:31972179   PMID:31996236   PMID:32442405   PMID:32587339   PMID:34348153   PMID:34358624   PMID:34927678   PMID:35012549   PMID:35187538   PMID:35427698   PMID:35830813   PMID:37039821  
PMID:37269057   PMID:38355793   PMID:38923264  


Genomics

Comparative Map Data
Mdk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39291,760,149 - 91,762,348 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl291,760,150 - 91,762,642 (-)EnsemblGRCm39 Ensembl
GRCm38291,929,805 - 91,932,297 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl291,929,805 - 91,932,297 (-)EnsemblGRCm38mm10GRCm38
MGSCv37291,769,978 - 91,772,439 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36291,730,660 - 91,733,121 (-)NCBIMGSCv36mm8
Celera293,320,223 - 93,322,680 (-)NCBICelera
Cytogenetic Map2E1NCBI
cM Map250.63NCBI
MDK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381146,380,784 - 46,383,837 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1146,380,756 - 46,383,837 (+)EnsemblGRCh38hg38GRCh38
GRCh371146,402,334 - 46,405,387 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361146,359,194 - 46,361,951 (+)NCBINCBI36Build 36hg18NCBI36
Build 341146,359,794 - 46,361,950NCBI
Celera1146,550,196 - 46,552,952 (+)NCBICelera
Cytogenetic Map11p11.2NCBI
HuRef1146,109,292 - 46,112,345 (+)NCBIHuRef
CHM1_11146,400,770 - 46,403,840 (+)NCBICHM1_1
T2T-CHM13v2.01146,536,860 - 46,539,912 (+)NCBIT2T-CHM13v2.0
Mdk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8398,356,789 - 98,358,960 (-)NCBIGRCr8
mRatBN7.2377,901,134 - 77,903,997 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl377,901,158 - 77,903,130 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx381,376,607 - 81,377,964 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0389,975,637 - 89,976,994 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0387,826,859 - 87,828,216 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0380,841,003 - 80,843,895 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl380,841,005 - 80,842,916 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0387,539,671 - 87,542,415 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4376,309,988 - 76,311,345 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1376,206,095 - 76,208,044 (-)NCBI
Celera377,104,074 - 77,105,431 (-)NCBICelera
Cytogenetic Map3q24NCBI
Mdk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554221,655,358 - 1,657,044 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554221,655,351 - 1,657,026 (-)NCBIChiLan1.0ChiLan1.0
MDK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2948,593,687 - 48,596,920 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11148,600,717 - 48,603,778 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01146,339,365 - 46,342,388 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11146,890,151 - 46,893,318 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1146,891,540 - 46,893,254 (+)Ensemblpanpan1.1panPan2
LOC491316
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1955,100,491 - 55,101,081 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha954,295,784 - 54,296,356 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0956,022,875 - 56,023,626 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl956,022,875 - 56,023,306 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1954,782,276 - 54,783,027 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0955,096,747 - 55,097,319 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0955,188,655 - 55,189,227 (+)NCBIUU_Cfam_GSD_1.0
Mdk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494720,576,217 - 20,578,924 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365622,687,825 - 2,689,484 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365622,687,825 - 2,690,292 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MDK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl216,130,788 - 16,133,510 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1216,130,787 - 16,133,791 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2217,476,834 - 17,479,834 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MDK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1118,945,355 - 18,948,394 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl118,946,378 - 18,947,134 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038116,230,790 - 116,233,817 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mdk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247672,171,096 - 2,173,512 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247672,171,096 - 2,173,436 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mdk
109 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:797
Count of miRNA genes:254
Interacting mature miRNAs:281
Transcripts:ENSMUST00000028672, ENSMUST00000069423, ENSMUST00000090602, ENSMUST00000111309
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11038697Ltpr2d_mLeishmania tropica response 2d (mouse)286095716120095823Mouse
11038698Ltpr2c_mLeishmania tropica response 2c (mouse)286095716120095823Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220897778118894840Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
13824983Vclq1_mcurvilinear velocity QTL 1 (mouse)261830344136841920Mouse
11528549Sluc31_msusceptibility to lung cancer 31 (mouse)274524117129213005Mouse
4141236Hbnr5_mHeligmosomoides bakeri nematode resistance 5 (mouse)Not determined31214567105143570Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
1301405Etohr_methanol response acute (mouse)Not determined26300595497006113Mouse
1301660Iba1_minduction of brown adipocytes 1 (mouse)Not determined267647887101648142Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
1301703Bomd3_mbone mineral density 3 (mouse)Not determined26300595497006113Mouse
11532731Sluc31a_msusceptibility to lung cancer 31a (mouse)288015003122015170Mouse
1301834Bits1_mbitterness sensitivity 1 (mouse)Not determined287440643121440778Mouse
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388712693421651Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220897778118894840Mouse
4141155Plast2b_mplasma plant sterol 2b (mouse)Not determined284013198148522175Mouse
1357577Trmq3_mT cell ratio modifier QTL 3 (mouse)Not determined260520612119355518Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220897778118894840Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229307947148374934Mouse
1301873Hsl1_mhyperoxia susceptibility locus 1 (mouse)Not determined26357015497570301Mouse
1558901Skmw8_mskeletal muscle weight 8 (mouse)Not determined284008488118008593Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220897778118894840Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220897778118894840Mouse
1300662Etohila_methanol induced locomotor activity (mouse)Not determined26300595497006113Mouse
1301109Dntcs2_mdental caries susceptibility 2 (mouse)Not determined240885493114910165Mouse
4141657Mohg1_mmodifier of hg 1 (mouse)Not determined276678758103095823Mouse
1300852Lmr14_mleishmaniasis resistance 14 (mouse)Not determined286095716120095823Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220897778118894840Mouse
10053681Lith24_mlithogenic gene 24 (mouse)Not determined26300595497006113Mouse
1301882Etohc2_methanol consumption 2 (mouse)Not determined268724269102724407Mouse
1301048Actre2_mactivity response to ethanol 2 (mouse)Not determined26300595497006113Mouse
10412082Hylaq1_mHyperlocomotor activity related QTL 1 (mouse)Not determined284013198148667470Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220897778118894840Mouse
1301374Cplaq7_mcircadian period of locomotor activity 7 (mouse)Not determined276421483110421651Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265269746162518926Mouse
1301948Elsgp3_melevated serum gp70 3 (mouse)Not determined268724269102724407Mouse
10043894Bw22_mbody weight QTL 22 (mouse)Not determined280895334114895334Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285724269180896594Mouse
15092054Egrme5_mearly growth rate, maternal effect 5 (mouse)282190187118004745Mouse
4142223Femwf4_mfemur work to failure 4 (mouse)Not determined88143423122143570Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245347635145312647Mouse
11049565Lmr28g_mleishmaniasis resistance 28g (mouse)286095716120095823Mouse
13463482Mchq17_mmean corpuscular hemoglobin QTL 17 (mouse)267647887101648142Mouse
4142088Parms1_mpatched associated RMS 1 (mouse)Not determined74524117114123532Mouse
1301098Cd8mts3_mCD8 memory T cell subset 3 (mouse)Not determined291089974125090104Mouse
10044002Hdl7_mHDL level 7 (mouse)Not determined26300595497006113Mouse
12738429Lfibq18_mliver fibrosis QTL 18 (mouse)25791999191919991Mouse

Markers in Region
D5Mit116  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38291,931,869 - 91,931,971UniSTSGRCm38
MGSCv37291,772,026 - 91,772,128UniSTSGRCm37
Celera293,322,271 - 93,322,373UniSTS
Cytogenetic Map2E1UniSTS
cM Map559.0UniSTS
cM Map2 UniSTS
Whitehead Genetic543.0705UniSTS
D5Mit116.1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38291,931,964 - 91,932,132UniSTSGRCm38
MGSCv37291,772,121 - 91,772,289UniSTSGRCm37
Celera293,322,366 - 93,322,534UniSTS
Cytogenetic Map2E1UniSTS
cM Map559.0UniSTS
cM Map2 UniSTS
Whitehead Genetic543.0705UniSTS
Mdk  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2E1UniSTS
cM Map253.0UniSTS
cM Map253.0UniSTS
D2Tfv15  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2E1UniSTS
cM Map253.0UniSTS
cM Map2 UniSTS
Chrm4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38291,928,665 - 91,929,877UniSTSGRCm38
MGSCv37291,768,822 - 91,770,034UniSTSGRCm37
Celera293,319,066 - 93,320,279UniSTS
Cytogenetic Map2E1UniSTS
cM Map249.0UniSTS
cM Map253.0UniSTS
Mdk  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2E1UniSTS
cM Map253.0UniSTS
Mdk-ps1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811102,545,743 - 102,545,814UniSTSGRCm38
GRCm38291,931,116 - 91,931,199UniSTSGRCm38
MGSCv3711102,407,057 - 102,407,128UniSTSGRCm37
MGSCv37291,771,273 - 91,771,356UniSTSGRCm37
Celera11114,256,015 - 114,256,086UniSTS
Celera293,321,518 - 93,321,601UniSTS
Cytogenetic Map11E1UniSTS
Cytogenetic Map2E1UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001012335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001012336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001291481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001291482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001291483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001420412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011239335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK032742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK084457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL364704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL731772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY864926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC012244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY092625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF728526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF731708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF738400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF740555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ174056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ174578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D14817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ323886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ323887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M19662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M34094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M34327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M34328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M35833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000028672   ⟹   ENSMUSP00000028672
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl291,760,173 - 91,762,642 (-)Ensembl
GRCm38.p6 Ensembl291,929,828 - 91,932,297 (-)Ensembl
Ensembl Acc Id: ENSMUST00000069423   ⟹   ENSMUSP00000068413
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl291,760,173 - 91,762,125 (-)Ensembl
GRCm38.p6 Ensembl291,929,828 - 91,931,780 (-)Ensembl
Ensembl Acc Id: ENSMUST00000090602   ⟹   ENSMUSP00000088090
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl291,760,311 - 91,762,044 (-)Ensembl
GRCm38.p6 Ensembl291,929,966 - 91,931,699 (-)Ensembl
Ensembl Acc Id: ENSMUST00000111309   ⟹   ENSMUSP00000106941
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl291,760,150 - 91,762,033 (-)Ensembl
GRCm38.p6 Ensembl291,929,805 - 91,931,688 (-)Ensembl
RefSeq Acc Id: NM_001012335   ⟹   NP_001012335
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39291,760,149 - 91,762,090 (-)NCBI
GRCm38291,929,805 - 91,931,702 (-)NCBI
MGSCv37291,769,978 - 91,772,439 (-)RGD
Celera293,320,207 - 93,322,695 (-)NCBI
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001012336   ⟹   NP_001012336
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39291,760,149 - 91,762,090 (-)NCBI
GRCm38291,929,805 - 91,931,859 (-)NCBI
MGSCv37291,769,978 - 91,772,439 (-)RGD
Celera293,320,207 - 93,322,695 (-)NCBI
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001291481   ⟹   NP_001278410
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39291,760,149 - 91,762,090 (-)NCBI
GRCm38291,929,805 - 91,931,702 (-)NCBI
Celera293,320,207 - 93,322,695 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001291482   ⟹   NP_001278411
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39291,760,149 - 91,762,090 (-)NCBI
GRCm38291,929,805 - 91,931,859 (-)NCBI
Celera293,320,207 - 93,322,695 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001291483   ⟹   NP_001278412
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39291,760,149 - 91,762,348 (-)NCBI
GRCm38291,929,805 - 91,932,297 (-)NCBI
Celera293,320,207 - 93,322,695 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001420412   ⟹   NP_001407341
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39291,760,149 - 91,762,090 (-)NCBI
RefSeq Acc Id: NM_010784   ⟹   NP_034914
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39291,760,149 - 91,762,348 (-)NCBI
GRCm38291,929,805 - 91,932,297 (-)NCBI
MGSCv37291,769,978 - 91,772,439 (-)RGD
Celera293,320,207 - 93,322,695 (-)NCBI
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011239335   ⟹   XP_011237637
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39291,760,166 - 91,762,120 (-)NCBI
GRCm38291,929,821 - 91,931,775 (-)NCBI
Sequence:
RefSeq Acc Id: NP_034914   ⟸   NM_010784
- Peptide Label: isoform a precursor
- UniProtKB: P12025 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001012336   ⟸   NM_001012336
- Peptide Label: isoform a precursor
- UniProtKB: P12025 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001012335   ⟸   NM_001012335
- Peptide Label: isoform a precursor
- UniProtKB: P12025 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001278412   ⟸   NM_001291483
- Peptide Label: isoform c precursor
- UniProtKB: Q2LEK5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001278411   ⟸   NM_001291482
- Peptide Label: isoform b
- Sequence:
RefSeq Acc Id: NP_001278410   ⟸   NM_001291481
- Peptide Label: isoform a precursor
- UniProtKB: P12025 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011237637   ⟸   XM_011239335
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSMUSP00000106941   ⟸   ENSMUST00000111309
Ensembl Acc Id: ENSMUSP00000088090   ⟸   ENSMUST00000090602
Ensembl Acc Id: ENSMUSP00000028672   ⟸   ENSMUST00000028672
Ensembl Acc Id: ENSMUSP00000068413   ⟸   ENSMUST00000069423
RefSeq Acc Id: NP_001407341   ⟸   NM_001420412
- Peptide Label: isoform b
Protein Domains
Pleiotrophin/Midkine C-terminal   Pleiotrophin/Midkine N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P12025-F1-model_v2 AlphaFold P12025 1-140 view protein structure

Promoters
RGD ID:6831784
Promoter ID:MM_KWN:30512
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell
Transcripts:ENSMUST00000111309,   ENSMUST00000111310,   NM_001012335,   NM_001012336,   OTTMUST00000033983,   UC008KWW.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36291,771,571 - 91,773,272 (-)MPROMDB
RGD ID:6877940
Promoter ID:EPDNEW_M2420
Type:initiation region
Name:Mdk_1
Description:Mus musculus midkine , transcript variant 6, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38291,931,745 - 91,931,805EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96949 AgrOrtholog
Ensembl Genes ENSMUSG00000027239 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000028672 ENTREZGENE
  ENSMUST00000028672.13 UniProtKB/Swiss-Prot
  ENSMUST00000069423 ENTREZGENE
  ENSMUST00000069423.13 UniProtKB/Swiss-Prot
  ENSMUST00000090602 ENTREZGENE
  ENSMUST00000090602.6 UniProtKB/Swiss-Prot
  ENSMUST00000111309 ENTREZGENE
  ENSMUST00000111309.8 UniProtKB/Swiss-Prot
Gene3D-CATH 2.20.60.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Heparin-binding Growth Factor, Midkine, Chain A- C-terminal Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Midkine_heparin-bd_GF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTN/MK_C_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTN/MK_C_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTN/MK_diS_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTN/MK_N_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTN/MK_N_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTN_MK_heparin-bd_GF_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17242 UniProtKB/Swiss-Prot
MGD MGI:96949 ENTREZGENE
NCBI Gene 17242 ENTREZGENE
PANTHER MIDKINE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR13850 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PTN_MK_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTN_MK_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mdk PhenoGen
PRINTS PTNMIDKINE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PTN_MK_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTN_MK_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PTN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57288 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt MK_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q2LEK5 ENTREZGENE, UniProtKB/TrEMBL
  Q2LEK6_MOUSE UniProtKB/TrEMBL
  Q8BN87_MOUSE UniProtKB/TrEMBL