Nobox (NOBOX oogenesis homeobox) - Rat Genome Database

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Gene: Nobox (NOBOX oogenesis homeobox) Mus musculus
Analyze
Symbol: Nobox
Name: NOBOX oogenesis homeobox
RGD ID: 1557267
MGI Page MGI
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within ovarian follicle development. Located in cytoplasm. Is expressed in several structures, including eye; genitourinary system; heart; liver; and musculoskeletal system. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 5. Orthologous to human NOBOX (NOBOX oogenesis homeobox).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: homeobox protein NOBOX; homeodomain-containing protein OG-2; newborn ovary homeobox protein; OG2; OG2 homeobox; Og2x; oocyte-specific homeobox protein
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39643,280,608 - 43,287,006 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl643,280,608 - 43,286,488 (-)EnsemblGRCm39 Ensembl
GRCm38643,303,674 - 43,310,072 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl643,303,674 - 43,309,554 (-)EnsemblGRCm38mm10GRCm38
MGSCv37643,253,673 - 43,259,553 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36643,233,281 - 43,239,169 (-)NCBIMGSCv36mm8
Celera643,251,662 - 43,257,542 (-)NCBICelera
Cytogenetic Map6B2.1NCBI
cM Map621.17NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. MGD IEA MGD IEA
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8855241   PMID:10725249   PMID:10922068   PMID:11804785   PMID:12477932   PMID:15326356   PMID:15489334   PMID:15618518   PMID:16416028   PMID:16690745   PMID:16997917   PMID:17494914  
PMID:17641088   PMID:18250097   PMID:18287559   PMID:18706558   PMID:19014927   PMID:19020301   PMID:19480014   PMID:20059953   PMID:20412781   PMID:20659469   PMID:20823249   PMID:21267068  
PMID:21369782   PMID:21478856   PMID:21504946   PMID:21677750   PMID:21873635   PMID:23585350   PMID:23759310   PMID:24194600   PMID:24357321   PMID:24952961   PMID:26412852   PMID:27065194  
PMID:27626380   PMID:28504655   PMID:28619824   PMID:31485074   PMID:31598710   PMID:31657143   PMID:32418930   PMID:32558204   PMID:34972250   PMID:35104175   PMID:35623357   PMID:36607631  
PMID:37493331   PMID:37494420  


Genomics

Comparative Map Data
Nobox
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39643,280,608 - 43,287,006 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl643,280,608 - 43,286,488 (-)EnsemblGRCm39 Ensembl
GRCm38643,303,674 - 43,310,072 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl643,303,674 - 43,309,554 (-)EnsemblGRCm38mm10GRCm38
MGSCv37643,253,673 - 43,259,553 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36643,233,281 - 43,239,169 (-)NCBIMGSCv36mm8
Celera643,251,662 - 43,257,542 (-)NCBICelera
Cytogenetic Map6B2.1NCBI
cM Map621.17NCBI
NOBOX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387144,396,900 - 144,410,227 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7144,397,240 - 144,410,227 (-)EnsemblGRCh38hg38GRCh38
GRCh377144,094,333 - 144,107,320 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367143,726,972 - 143,738,253 (-)NCBINCBI36Build 36hg18NCBI36
Celera7138,768,371 - 138,774,825 (-)NCBICelera
Cytogenetic Map7q35NCBI
HuRef7138,172,481 - 138,185,362 (-)NCBIHuRef
CHM1_17144,102,822 - 144,115,800 (-)NCBICHM1_1
T2T-CHM13v2.07145,577,071 - 145,590,391 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27143,432,585 - 143,445,573 (-)NCBI
Nobox
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8473,128,926 - 73,134,431 (-)NCBIGRCr8
mRatBN7.2472,128,931 - 72,134,436 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl472,128,931 - 72,134,436 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx477,116,956 - 77,122,446 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0473,030,187 - 73,035,677 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0471,419,402 - 71,424,914 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0472,749,239 - 72,757,066 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl472,751,382 - 72,756,887 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04137,454,563 - 137,460,365 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4471,072,318 - 71,077,823 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera467,074,709 - 67,080,214 (-)NCBICelera
Cytogenetic Map4q24NCBI
Nobox
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955491575,413 - 580,460 (-)NCBIChiLan1.0ChiLan1.0
NOBOX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26180,970,095 - 180,983,085 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1732,980,378 - 32,993,342 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07136,111,451 - 136,124,418 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17148,599,693 - 148,612,657 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7148,599,700 - 148,612,657 (-)Ensemblpanpan1.1panPan2
NOBOX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1165,625,279 - 5,638,052 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha166,743,111 - 6,749,429 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0165,495,072 - 5,501,389 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl165,495,035 - 5,501,106 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1165,427,807 - 5,432,663 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0165,283,408 - 5,289,715 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0165,354,169 - 5,360,489 (+)NCBIUU_Cfam_GSD_1.0
Nobox
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511811,489,109 - 11,492,541 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365271,411,403 - 1,417,041 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOBOX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9113,348,363 - 113,354,502 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19113,348,363 - 113,354,504 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29124,774,085 - 124,780,353 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NOBOX
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121113,032,304 - 113,052,090 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21113,034,100 - 113,047,037 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660729,810,433 - 9,828,445 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nobox
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462480010,827,528 - 10,833,231 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nobox
224 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:362
Count of miRNA genes:193
Interacting mature miRNAs:202
Transcripts:ENSMUST00000031749, ENSMUST00000172554, ENSMUST00000183706
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)63050001117476961Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487403016Mouse
11353840Bmiq2_mbody mass index QTL 2 (mouse)6450382345291115Mouse
1357520Axtq2_manxiety QTL 2 (mouse)Not determined6450382348703611Mouse
1357481Aaj2_manxiety in A/J 2 (mouse)Not determined6450382348703611Mouse
11353841Bmiq3_mbody mass index QTL 3 (mouse)6450382348703611Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396633110Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396633110Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396633110Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396633110Mouse
26884441Sklq3_mskull length QTL 3, 5 week (mouse)6760000080576983Mouse
1302051Sluc7_msusceptibility to lung cancer 7 (mouse)Not determined6929707443297168Mouse
10043869Cia6a_mcollagen induced arthritis QTL 6a (mouse)Not determined61211797146118069Mouse
4141749Obrq2_mobesity resistance QTL 2 (mouse)Not determined1275122146751333Mouse
1301998Bts2_mbladder tumor susceptibility 2 (mouse)Not determined61275122146751333Mouse
27226726Tibmd7_mtibia midshaft diameter 7, 16 week (mouse)61769999953476985Mouse
1301850Fglu_mfasting glucose (mouse)Not determined61771159851711719Mouse
1301724Pcd4ts1_mp-glycoprotein positive CD4 T cell subset 1 (mouse)Not determined61771159851711719Mouse
4140989Spqq2_msperm quality QTL 2 (mouse)Not determined1771159851711719Mouse
1357442Dbts1_mdiabetes 1 (mouse)Not determined61823414773364675Mouse
12904940Edlmmq5_mextensor digitorum longus muscle mass QTL 5 (mouse)61961634653616346Mouse
12904943Tammq4_mtibialis anterior muscle mass QTL 4 (mouse)61961634653616346Mouse
12904952Gmmq4_mgastrocnemius muscle mass QTL 4 (mouse)61961634653616346Mouse
10412213Sxbq2_mSGC/Knj cross B6 QTL 2 (mouse)Not determined61991268571299759Mouse
10412107Desp4_mdespair 4 (mouse)Not determined62004983054049830Mouse
14700690Ccs6_mcolon cancer susceptibility 6 (mouse)62377693457776934Mouse
13208564Bmiq7_mbody mass index QTL 7 (mouse)62499999979976983Mouse
4141988Obrq3_mobesity resistance QTL 3 (mouse)Not determined2829099362291115Mouse
4141454Obrq4_mobesity resistance QTL 4 (mouse)Not determined3170349965703611Mouse
12880425V25Dq5_mvitamin D inactive form serum level QTL 5 (mouse)63267698066676980Mouse
4141782Mrdq5_mmodifier of retinal degeneration QTL 5 (mouse)Not determined3282758578215957Mouse
1300959Lxw2_mlupus BXSB x NZW 2 (mouse)Not determined63387226167872400Mouse
11252142Mom12_mModifier of Min 12 (mouse)63387226167872400Mouse
1300767Aliq4_macute lung injury QTL 4 (mouse)Not determined63627333270273435Mouse
1357539Bsbob3_mBSB obesity 3 (mouse)Not determined63644845670448576Mouse
4141094Hrtr1_mheart rate 1 (mouse)Not determined3674146370741463Mouse
14746995Manh60_mmandible shape 60 (mouse)63720266271202662Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63864656092584431Mouse
1301326Trbv4c2_mT cell receptor beta variable 4 (mouse)Not determined64086823071356155Mouse
12880424V25Dq4_mvitamin D inactive form serum level QTL 4 (mouse)64157698575576985Mouse
11040600Lmr4c_mleishmaniasis resistance 4c (mouse)64209335876093500Mouse
11040601Lmr4a_mleishmaniasis resistance 4a (mouse)64209335876093500Mouse
11533915Mts4_mmammary tumor susceptibility 4 (mouse)64209335876093500Mouse
1301266Lmr4_mleishmaniasis resistance 4 (mouse)Not determined64209335876093500Mouse

Markers in Region
Nobox  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38643,306,748 - 43,307,253UniSTSGRCm38
MGSCv37643,256,747 - 43,257,252UniSTSGRCm37
Celera643,254,736 - 43,255,241UniSTS
Cytogenetic Map6B2.1UniSTS
cM Map618.3UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000031749   ⟹   ENSMUSP00000031749
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl643,280,608 - 43,286,488 (-)Ensembl
GRCm38.p6 Ensembl643,303,674 - 43,309,554 (-)Ensembl
RefSeq Acc Id: ENSMUST00000172554   ⟹   ENSMUSP00000133353
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl643,280,832 - 43,284,170 (-)Ensembl
GRCm38.p6 Ensembl643,303,898 - 43,307,236 (-)Ensembl
RefSeq Acc Id: ENSMUST00000183706
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl643,280,634 - 43,282,069 (-)Ensembl
GRCm38.p6 Ensembl643,303,700 - 43,305,135 (-)Ensembl
RefSeq Acc Id: NM_130869   ⟹   NP_570939
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39643,280,608 - 43,286,488 (-)NCBI
GRCm38643,303,674 - 43,309,554 (-)NCBI
MGSCv37643,253,673 - 43,259,553 (-)RGD
Celera643,251,662 - 43,257,542 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030255220   ⟹   XP_030111080
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39643,280,731 - 43,287,006 (-)NCBI
GRCm38643,303,797 - 43,310,072 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_570939   ⟸   NM_130869
- UniProtKB: P70367 (UniProtKB/Swiss-Prot),   Q8VIH1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030111080   ⟸   XM_030255220
- Peptide Label: isoform X1
RefSeq Acc Id: ENSMUSP00000031749   ⟸   ENSMUST00000031749
RefSeq Acc Id: ENSMUSP00000133353   ⟸   ENSMUST00000172554
Protein Domains
Homeobox

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VIH1-F1-model_v2 AlphaFold Q8VIH1 1-527 view protein structure

Promoters
RGD ID:6889554
Promoter ID:EPDNEW_M8228
Type:single initiation site
Name:Nobox_1
Description:Mus musculus NOBOX oogenesis homeobox , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38643,309,476 - 43,309,536EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:108011 AgrOrtholog
Ensembl Genes ENSMUSG00000029736 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000031749 ENTREZGENE
  ENSMUST00000031749.16 UniProtKB/Swiss-Prot
  ENSMUST00000172554.4 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18291 UniProtKB/Swiss-Prot
MGD MGI:108011 ENTREZGENE
NCBI Gene 18291 ENTREZGENE
PANTHER HOMEOBOX PROTEIN NOBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR47060 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nobox PhenoGen
PROSITE HOMEOBOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt G3UWN1_MOUSE UniProtKB/TrEMBL
  NOBOX_MOUSE UniProtKB/Swiss-Prot
  P70367 ENTREZGENE
  Q8VIH1 ENTREZGENE
UniProt Secondary P70367 UniProtKB/Swiss-Prot