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Gene: Aifm1 (apoptosis-inducing factor, mitochondrion-associated 1) Mus musculus
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Symbol: Aifm1
Name: apoptosis-inducing factor, mitochondrion-associated 1
Description: Exhibits DNA binding activity; FAD binding activity; and NAD(P)H oxidase activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; neuron apoptotic process; and regulation of apoptotic DNA fragmentation. Localizes to the cytosol; mitochondrion; and nucleus. Used to study mitochondrial complex I deficiency. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease X-linked recessive 4; X-linked nonsyndromic deafness; and combined oxidative phosphorylation deficiency. Is expressed in several structures, including early embryo and retina. Orthologous to human AIFM1 (apoptosis inducing factor mitochondria associated 1); PARTICIPATES IN ceramide signaling pathway; apoptotic cell death pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AIF; AIFsh2; apoptosis-inducing factor 1, mitochondrial; harlequin; Hq; mAIF; MGC5706; Pdcd8; programmed cell death 8; programmed cell death protein 8
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 EnsemblX48,474,944 - 48,513,563 (-)Ensembl
GRCm38X48,474,944 - 48,513,563 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37X45,828,121 - 45,866,603 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X44,719,571 - 44,758,053 (-)NCBImm8
CeleraX35,976,732 - 36,015,196 (-)NCBICelera
Cytogenetic MapX A5NCBI
cM MapX25.68NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

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Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
 
More on Aifm1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731381
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-12-31
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.