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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:macrolide
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Accession:CHEBI:25106 term browser browse the term
Definition:A macrocyclic lactone with a ring of twelve or more members derived from a polyketide.
Synonyms:related_synonym: Makrolid;   macrolides
 xref: Wikipedia:Macrolide


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(E)-roxithromycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Roxithromycin results in decreased expression of BCL2 protein CTD PMID:12921874 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases activity ISO Roxithromycin results in decreased activity of CYP2B6 protein CTD PMID:17164692 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Faslg Fas ligand increases expression ISO Roxithromycin results in increased expression of FASLG protein CTD PMID:12921874 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Roxithromycin results in increased expression of FOS mRNA; Roxithromycin results in increased expression of FOS protein CTD PMID:32454074 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
Roxithromycin inhibits the reaction [Mustard Gas results in increased expression of IL1B mRNA]; Roxithromycin inhibits the reaction [Mustard Gas results in increased expression of IL1B protein]
Roxithromycin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
CTD PMID:17524151, PMID:18197913 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Roxithromycin inhibits the reaction [Mustard Gas results in increased expression of IL6 mRNA]; Roxithromycin inhibits the reaction [Mustard Gas results in increased expression of IL6 protein] CTD PMID:17524151 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itgb4 integrin subunit beta 4 decreases expression ISO Roxithromycin results in decreased expression of ITGB4 protein CTD PMID:14687228 NCBI chr10:104,524,000...104,560,180
Ensembl chr10:104,523,996...104,561,078
JBrowse link
G Lamc2 laminin subunit gamma 2 decreases expression ISO Roxithromycin results in decreased expression of LAMC2 protein CTD PMID:14687228 NCBI chr13:70,566,643...70,632,126
Ensembl chr13:70,566,643...70,626,252
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions EXP Roxithromycin inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC mRNA]; Roxithromycin inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC protein] CTD PMID:18197913 NCBI chr 1:214,725,482...214,756,653 JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP Roxithromycin inhibits the reaction [Diethylnitrosamine results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:16061884 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
Roxithromycin inhibits the reaction [Mustard Gas results in increased expression of NOS2 protein]
Roxithromycin inhibits the reaction [Diethylnitrosamine results in increased activity of NOS2 protein]
CTD PMID:16061884, PMID:17524151 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Roxithromycin inhibits the reaction [Diethylnitrosamine results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:16061884 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
Roxithromycin inhibits the reaction [Mustard Gas results in increased expression of TNF mRNA]; Roxithromycin inhibits the reaction [Mustard Gas results in increased expression of TNF protein]
Roxithromycin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
CTD PMID:17524151, PMID:18197913 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
22,23-dihydroavermectin B1a term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO 22,23-dihydroavermectin B(1)a inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein affects the localization of NCOA2 protein]] CTD PMID:25257666 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO 22,23-dihydroavermectin B(1)a inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein affects the localization of NCOA2 protein]]; 22,23-dihydroavermectin B(1)a inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; 22,23-dihydroavermectin B(1)a inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
abamectin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression
decreases response to substance
decreases expression
decreases activity
ISO
EXP
abamectin inhibits the reaction [ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]
abamectin results in increased expression of ABCB1A mRNA
[Ascorbic Acid co-treated with Sesame Oil] inhibits the reaction [abamectin results in increased expression of ABCB1A mRNA]; Ascorbic Acid inhibits the reaction [abamectin results in increased expression of ABCB1A mRNA]; Sesame Oil inhibits the reaction [abamectin results in increased expression of ABCB1A mRNA]
ABCB1A protein results in decreased susceptibility to abamectin
abamectin results in decreased expression of ABCB1A protein
abamectin results in decreased activity of ABCB1A protein
abamectin inhibits the reaction [ABCB1A protein results in increased transport of bisbenzimide ethoxide trihydrochloride]
abamectin results in decreased activity of ABCB1 protein
CTD PMID:9144452, PMID:17134887, PMID:19879343, PMID:25865432, PMID:31739238 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions
decreases activity
ISO abamectin inhibits the reaction [ABCC1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]
abamectin results in decreased activity of ABCC1 protein
CTD PMID:25865432 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Actb actin, beta decreases expression ISO abamectin results in decreased expression of ACTB protein CTD PMID:19879343 NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases expression ISO abamectin results in decreased expression of AKT1 protein CTD PMID:30958899 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Casp3 caspase 3 increases activity
increases expression
multiple interactions
ISO
EXP
abamectin results in increased activity of CASP3 protein
abamectin results in increased expression of CASP3 protein
[Ascorbic Acid co-treated with Sesame Oil] inhibits the reaction [abamectin results in increased expression of CASP3 protein]; Ascorbic Acid inhibits the reaction [abamectin results in increased expression of CASP3 protein]; Sesame Oil inhibits the reaction [abamectin results in increased expression of CASP3 protein]
CTD PMID:30958899, PMID:31739238 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase multiple interactions
increases activity
EXP [Ascorbic Acid co-treated with Sesame Oil] inhibits the reaction [abamectin results in increased activity of CAT protein]; Ascorbic Acid inhibits the reaction [abamectin results in increased activity of CAT protein]; Sesame Oil inhibits the reaction [abamectin results in increased activity of CAT protein] CTD PMID:31739238 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases expression
EXP [Ascorbic Acid co-treated with Sesame Oil] inhibits the reaction [abamectin results in increased expression of CYP2E1 protein]; Ascorbic Acid inhibits the reaction [abamectin results in increased expression of CYP2E1 protein]; Sesame Oil inhibits the reaction [abamectin results in increased expression of CYP2E1 protein] CTD PMID:31739238 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO abamectin inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; abamectin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Sqstm1 sequestosome 1 decreases expression ISO abamectin results in decreased expression of SQSTM1 protein CTD PMID:30958899 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
EXP abamectin results in increased expression of TNF protein
[Ascorbic Acid co-treated with Sesame Oil] inhibits the reaction [abamectin results in increased expression of TNF protein]; Ascorbic Acid inhibits the reaction [abamectin results in increased expression of TNF protein]; Sesame Oil inhibits the reaction [abamectin results in increased expression of TNF protein]
CTD PMID:31739238 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tubb3 tubulin, beta 3 class III decreases expression ISO abamectin results in decreased expression of TUBB3 protein CTD PMID:19879343 NCBI chr19:56,220,759...56,229,813
Ensembl chr19:56,220,755...56,229,813
JBrowse link
alpha-Zearalanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afp alpha-fetoprotein affects binding EXP Zeranol binds to AFP protein CTD PMID:25349334 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Zeranol inhibits the reaction [Homocysteine results in increased expression of BAX protein] CTD PMID:16757814 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
ISO Zeranol inhibits the reaction [Homocysteine results in decreased expression of BCL2 protein]
Zeranol results in increased expression of BCL2 protein
CTD PMID:16757814, PMID:27224899 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO Zeranol results in decreased expression of BCL2L1 protein CTD PMID:24120472 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Ccnd1 cyclin D1 increases expression
decreases expression
ISO Zeranol results in increased expression of CCND1 protein
Zeranol results in decreased expression of CCND1 protein
CTD PMID:22113133, PMID:24120472 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO Zeranol results in decreased expression of CDK2 protein CTD PMID:24120472 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO Zeranol results in decreased expression of CDK4 protein CTD PMID:24120472 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 increases expression ISO Zeranol results in increased expression of CITED2 mRNA CTD PMID:11331657 NCBI chr 1:12,823,363...12,825,806
Ensembl chr 1:12,823,363...12,825,786
JBrowse link
G Crh corticotropin releasing hormone multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Zeranol results in increased expression of CRH mRNA]
Zeranol results in increased expression of CRH mRNA; Zeranol results in increased expression of CRH protein
CTD PMID:23538034 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 increases expression ISO Zeranol results in increased expression of CRHR1 mRNA CTD PMID:24120472 NCBI chr10:92,191,473...92,233,662
Ensembl chr10:92,191,718...92,232,645
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO Zeranol inhibits the reaction [Homocysteine affects the expression of EDN1 protein] CTD PMID:16757814 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Esr1 estrogen receptor 1 affects binding
increases activity
ISO
EXP
Zeranol binds to ESR1 protein
Zeranol results in increased activity of ESR1 protein
CTD PMID:11331656, PMID:19913605, PMID:30742918 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 affects binding EXP
ISO
Zeranol binds to ESR2 protein CTD PMID:19913605, PMID:30742918 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Gstm3 glutathione S-transferase mu 3 increases expression ISO Zeranol results in increased expression of GSTM3 mRNA CTD PMID:11331657 NCBI chr 2:210,685,204...210,688,273
Ensembl chr 2:210,685,197...210,688,272
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 increases expression ISO Zeranol results in increased expression of GSTM3 mRNA CTD PMID:11331657 NCBI chr 2:210,685,338...210,688,133
Ensembl chr 2:210,685,197...210,688,272
JBrowse link
G Ifng interferon gamma decreases secretion ISO Zeranol results in decreased secretion of IFNG protein CTD PMID:14636701 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Jag1 jagged canonical Notch ligand 1 increases expression ISO Zeranol results in increased expression of JAG1 protein CTD PMID:22113133 NCBI chr 3:130,079,361...130,114,781
Ensembl chr 3:130,079,361...130,114,770
JBrowse link
G Maoa monoamine oxidase A increases expression ISO Zeranol results in increased expression of MAOA mRNA CTD PMID:10811566, PMID:11331657 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases expression
increases phosphorylation
multiple interactions
increases expression
ISO Zeranol results in decreased expression of MAPK1 protein
Zeranol results in increased phosphorylation of MAPK1 protein
ethyl-1-(4-(2*3*3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate inhibits the reaction [Zeranol results in increased phosphorylation of MAPK1 protein]; ML 204 inhibits the reaction [Zeranol results in increased phosphorylation of MAPK1 protein]
Zeranol results in increased expression of MAPK1 protein modified form
CTD PMID:23538034, PMID:24120472, PMID:27224899 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases expression
increases phosphorylation
multiple interactions
decreases expression
ISO Zeranol results in increased expression of MAPK3 protein modified form
Zeranol results in increased phosphorylation of MAPK3 protein
ethyl-1-(4-(2*3*3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate inhibits the reaction [Zeranol results in increased phosphorylation of MAPK3 protein]; ML 204 inhibits the reaction [Zeranol results in increased phosphorylation of MAPK3 protein]
Zeranol results in decreased expression of MAPK3 protein
CTD PMID:23538034, PMID:24120472, PMID:27224899 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mir34b microRNA 34b decreases expression ISO Zeranol results in decreased expression of MIR34B mRNA CTD PMID:22113133 NCBI chr 8:55,492,542...55,492,625
Ensembl chr 8:55,492,542...55,492,625
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO Zeranol inhibits the reaction [Homocysteine results in decreased expression of NOS3 protein] CTD PMID:16757814 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Pgr progesterone receptor increases expression ISO Zeranol results in increased expression of PGR mRNA CTD PMID:24120472 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel increases expression ISO Zeranol results in increased expression of PKD2 protein CTD PMID:27224899 NCBI chr14:6,602,004...6,645,257
Ensembl chr14:6,602,004...6,645,257
JBrowse link
G Prkcb protein kinase C, beta multiple interactions
increases phosphorylation
ISO ethyl-1-(4-(2*3*3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate inhibits the reaction [Zeranol results in increased phosphorylation of PRKCB protein] CTD PMID:27224899 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831
JBrowse link
G Prkcd protein kinase C, delta increases expression ISO Zeranol results in increased expression of PRKCD protein modified form CTD PMID:23538034 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO ethyl-1-(4-(2*3*3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate inhibits the reaction [Zeranol results in increased expression of PTGS2 mRNA]; ethyl-1-(4-(2*3*3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate inhibits the reaction [Zeranol results in increased expression of PTGS2 protein] CTD PMID:27224899 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptma prothymosin alpha decreases expression EXP Zeranol results in decreased expression of PTMA protein alternative form CTD PMID:10606005 NCBI chr 9:93,545,396...93,549,436
Ensembl chr 9:93,545,396...93,549,436
JBrowse link
G Rln1 relaxin 1 increases expression ISO Zeranol results in increased expression of RLN1 mRNA CTD PMID:24120472 NCBI chr 1:247,483,298...247,486,331
Ensembl chr 1:247,483,302...247,486,202
JBrowse link
G Serpina3m serpin family A member 3M increases expression ISO Zeranol results in increased expression of SERPINA3 mRNA CTD PMID:10811566 NCBI chr 6:127,808,785...127,816,067
Ensembl chr 6:127,808,785...127,816,055
JBrowse link
G Shbg sex hormone binding globulin affects binding ISO Zeranol binds to SHBG protein CTD PMID:25349334 NCBI chr10:56,219,861...56,237,354
Ensembl chr10:56,219,858...56,223,245
JBrowse link
G Slc6a14 solute carrier family 6 member 14 increases expression ISO Zeranol results in increased expression of SLC6A14 mRNA CTD PMID:11331657 NCBI chr  X:120,624,522...120,647,964
Ensembl chr  X:120,624,518...120,649,111
JBrowse link
G Tff1 trefoil factor 1 increases expression ISO Zeranol results in increased expression of TFF1 mRNA CTD PMID:10811566, PMID:11331657 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
JBrowse link
G Tgfb3 transforming growth factor, beta 3 increases expression ISO Zeranol results in increased expression of TGFB3 mRNA CTD PMID:10811566, PMID:11331657 NCBI chr 6:109,913,757...109,936,217
Ensembl chr 6:109,913,757...109,935,533
JBrowse link
G Trpc3 transient receptor potential cation channel, subfamily C, member 3 increases expression ISO Zeranol results in increased expression of TRPC3 protein CTD PMID:27224899 NCBI chr 2:123,329,954...123,467,574
Ensembl chr 2:123,329,875...123,407,496
JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 increases expression ISO Zeranol results in increased expression of TRPC6 protein CTD PMID:27224899 NCBI chr 8:6,811,543...6,917,534
Ensembl chr 8:6,811,543...6,917,535
JBrowse link
amphotericin B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arhgef26 Rho guanine nucleotide exchange factor 26 increases expression ISO Amphotericin B results in increased expression of ARHGEF26 mRNA CTD PMID:20849824 NCBI chr 2:27,107,263...27,236,336
Ensembl chr 2:27,107,318...27,236,672
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO Amphotericin B inhibits the reaction [[HIF1A protein binds to ARNT protein] which binds to EPO enhancer] CTD PMID:16189267 NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179
JBrowse link
G Atg3 autophagy related 3 decreases expression ISO Amphotericin B results in decreased expression of ATG3 mRNA CTD PMID:20849824 NCBI chr11:60,585,192...60,613,706
Ensembl chr11:60,585,171...60,613,718
JBrowse link
G Casp3 caspase 3 increases expression ISO Amphotericin B results in increased expression of CASP3 protein CTD PMID:23988732 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase decreases expression EXP Amphotericin B results in decreased expression of CAT mRNA CTD PMID:20623750 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 decreases expression EXP Amphotericin B results in decreased expression of CCR2 mRNA CTD PMID:20623750
G Clu clusterin affects expression EXP Amphotericin B affects the expression of CLU mRNA CTD PMID:20623750 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Ednrb endothelin receptor type B increases expression ISO Amphotericin B results in increased expression of EDNRB mRNA CTD PMID:20849824 NCBI chr15:88,004,775...88,036,354
Ensembl chr15:88,006,977...88,036,354
JBrowse link
G Eno1 enolase 1 multiple interactions ISO Amphotericin B inhibits the reaction [Oxygen deficiency results in increased expression of ENO1 mRNA]; Amphotericin B results in increased expression of and results in increased secretion of ENO1 protein CTD PMID:16189267, PMID:26259607 NCBI chr 5:167,288,223...167,299,610
Ensembl chr 5:167,288,223...167,299,609
JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO Amphotericin B inhibits the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]] CTD PMID:16189267 NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296
JBrowse link
G Epo erythropoietin multiple interactions
decreases expression
ISO
EXP
Amphotericin B inhibits the reaction [[HIF1A protein binds to ARNT protein] which binds to EPO enhancer]; Amphotericin B inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]
Amphotericin B results in decreased expression of EPO protein
CTD PMID:697352, PMID:2299214, PMID:16189267 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G Glod4 glyoxalase domain containing 4 decreases expression ISO Amphotericin B results in decreased expression of GLOD4 mRNA CTD PMID:20849824 NCBI chr10:64,379,922...64,398,263
Ensembl chr10:64,379,921...64,398,294
JBrowse link
G Gpr20 G protein-coupled receptor 20 increases expression ISO Amphotericin B results in increased expression of GPR20 mRNA CTD PMID:20849824 NCBI chr 7:114,943,675...114,953,977
Ensembl chr 7:114,944,282...114,945,344
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases expression
multiple interactions
EXP
ISO
Amphotericin B results in decreased expression of GSTP1 mRNA
Amphotericin B inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate]
CTD PMID:20623750, PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Gstt1 glutathione S-transferase theta 1 decreases expression EXP Amphotericin B results in decreased expression of GSTT1 mRNA CTD PMID:20623750 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
decreases activity
ISO Amphotericin B inhibits the reaction [[HIF1A protein binds to ARNT protein] which binds to EPO enhancer]; Amphotericin B inhibits the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]]; Amphotericin B promotes the reaction [HIF1AN protein binds to and results in increased hydroxylation of and results in decreased activity of HIF1A protein]
Amphotericin B results in decreased activity of HIF1A protein
CTD PMID:16189267 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hif1an hypoxia inducible factor 1 subunit alpha inhibitor multiple interactions ISO Amphotericin B promotes the reaction [HIF1AN protein binds to and results in increased hydroxylation of and results in decreased activity of HIF1A protein] CTD PMID:16189267 NCBI chr 1:264,309,214...264,319,269
Ensembl chr 1:264,309,214...264,319,267
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 multiple interactions ISO Amphotericin B results in increased expression of and results in increased secretion of HSPA8 protein CTD PMID:26259607 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Ifng interferon gamma multiple interactions ISO [Amphotericin B co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA; [Antimony Sodium Gluconate co-treated with Amphotericin B] results in increased expression of IFNG protein CTD PMID:17911647, PMID:29594315 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Ifngr1 interferon gamma receptor 1 increases expression ISO Amphotericin B results in increased expression of IFNGR1 CTD PMID:12803856 NCBI chr 1:15,062,380...15,080,815
Ensembl chr 1:15,062,432...15,080,907
JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 decreases expression ISO Amphotericin B results in decreased expression of IGFBP5 mRNA CTD PMID:20849824 NCBI chr 9:80,154,230...80,166,813
Ensembl chr 9:80,150,211...80,167,033
JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Antimony Sodium Gluconate co-treated with Amphotericin B] results in decreased expression of IL10 protein CTD PMID:17911647 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta increases expression ISO Amphotericin B results in increased expression of IL1B mRNA CTD PMID:29594315 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Amphotericin B co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA CTD PMID:29594315 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Kcnq4 potassium voltage-gated channel subfamily Q member 4 decreases expression ISO Amphotericin B results in decreased expression of KCNQ4 mRNA CTD PMID:20849824 NCBI chr 5:139,625,783...139,677,300
Ensembl chr 5:139,627,576...139,677,300
JBrowse link
G Lsg1 large 60S subunit nuclear export GTPase 1 decreases expression ISO Amphotericin B results in decreased expression of LSG1 mRNA CTD PMID:20849824 NCBI chr11:73,693,862...73,723,457
Ensembl chr11:73,693,814...73,723,501
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression ISO Amphotericin B results in increased expression of MAP1LC3B protein CTD PMID:23988732 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Nprl2 NPR2-like, GATOR1 complex subunit decreases expression ISO Amphotericin B results in decreased expression of NPRL2 mRNA CTD PMID:20849824 NCBI chr 8:116,297,950...116,301,123
Ensembl chr 8:116,297,950...116,301,122
JBrowse link
G Nt5c2 5'-nucleotidase, cytosolic II increases expression ISO Amphotericin B results in increased expression of NT5C2 mRNA CTD PMID:20849824 NCBI chr 1:266,652,966...266,782,935
Ensembl chr 1:266,659,519...266,782,910
JBrowse link
G Paip1 poly(A) binding protein interacting protein 1 decreases expression ISO Amphotericin B results in decreased expression of PAIP1 mRNA CTD PMID:20849824 NCBI chr 2:52,300,921...52,328,212
Ensembl chr 2:52,301,798...52,328,205
JBrowse link
G Pard3 par-3 family cell polarity regulator decreases expression ISO Amphotericin B results in decreased expression of PARD3 mRNA CTD PMID:20849824 NCBI chr19:60,017,746...60,580,628
Ensembl chr19:60,017,746...60,580,651
JBrowse link
G Pgk1 phosphoglycerate kinase 1 multiple interactions ISO Amphotericin B inhibits the reaction [Oxygen deficiency results in increased expression of PGK1 mRNA] CTD PMID:16189267 NCBI chr  X:77,263,399...77,279,373
Ensembl chr  X:77,263,359...77,279,367
JBrowse link
G Polm DNA polymerase mu increases expression ISO Amphotericin B results in increased expression of POLM mRNA CTD PMID:20849824 NCBI chr14:86,069,378...86,079,327
Ensembl chr14:86,069,016...86,078,954
JBrowse link
G RT1-CE5 RT1 class I, locus CE5 increases expression ISO Amphotericin B results in increased expression of HLA-F mRNA CTD PMID:20849824 NCBI chr20:4,892,702...4,896,993
Ensembl chr20:4,892,702...4,896,991
JBrowse link
G Runx3 RUNX family transcription factor 3 decreases expression ISO Amphotericin B results in decreased expression of RUNX3 mRNA CTD PMID:20849824 NCBI chr 5:153,507,093...153,531,137
Ensembl chr 5:153,507,093...153,531,137
JBrowse link
G Slit1 slit guidance ligand 1 decreases expression ISO Amphotericin B results in decreased expression of SLIT1 mRNA CTD PMID:20849824 NCBI chr 1:260,843,481...260,992,366
Ensembl chr 1:260,843,483...260,992,366
JBrowse link
G Spp1 secreted phosphoprotein 1 affects expression EXP Amphotericin B affects the expression of SPP1 mRNA CTD PMID:20623750 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [Antimony Sodium Gluconate co-treated with Amphotericin B] results in decreased expression of TGFB1 protein CTD PMID:17911647 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor increases expression EXP Amphotericin B results in increased expression of TNF mRNA CTD PMID:20623750 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 affects expression EXP Amphotericin B affects the expression of UGT1A9 mRNA CTD PMID:20623750 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Usp36 ubiquitin specific peptidase 36 increases expression ISO Amphotericin B results in increased expression of USP36 mRNA CTD PMID:20849824 NCBI chr10:107,292,828...107,324,355
Ensembl chr10:107,292,828...107,324,355
JBrowse link
amphotericin B methyl ester term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Havcr1 hepatitis A virus cellular receptor 1 increases expression ISO methylamphotericin B results in increased expression of HAVCR1 mRNA CTD PMID:22863853 NCBI chr10:31,813,819...31,860,934
Ensembl chr10:31,813,814...31,848,379
JBrowse link
G Lcn2 lipocalin 2 increases expression ISO methylamphotericin B results in increased expression of LCN2 mRNA CTD PMID:22863853 NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546
JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression ISO methylamphotericin B results in increased expression of SPP1 mRNA CTD PMID:22863853 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO methylamphotericin B results in increased expression of TIMP1 mRNA CTD PMID:22863853 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
ANTIMYCIN term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO antimycin results in decreased activity of ABCB11 protein CTD PMID:20829430 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Agt angiotensinogen multiple interactions EXP antimycin inhibits the reaction [AGT protein results in increased degradation of NFKBIA protein] CTD PMID:10712386 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation ISO antimycin results in increased phosphorylation of AKT1 protein CTD PMID:19901985 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression ISO antimycin results in increased expression of BCL2L1 protein CTD PMID:10463952 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp3 caspase 3 multiple interactions ISO antimycin results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:10463952 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP antimycin inhibits the reaction [AGT protein results in increased degradation of NFKBIA protein] CTD PMID:10712386 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Pax3 paired box 3 decreases expression ISO antimycin results in decreased expression of PAX3 mRNA CTD PMID:12739027 NCBI chr 9:84,004,004...84,101,226
Ensembl chr 9:84,005,183...84,101,172
JBrowse link
G Plcg1 phospholipase C, gamma 1 increases phosphorylation ISO antimycin results in increased phosphorylation of PLCG1 protein CTD PMID:19901985 NCBI chr 3:156,727,642...156,758,307
Ensembl chr 3:156,727,642...156,758,307
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 increases phosphorylation ISO antimycin results in increased phosphorylation of PRKAA1 protein CTD PMID:19901985 NCBI chr 2:54,857,688...54,893,404
Ensembl chr 2:54,857,688...54,893,404
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation
multiple interactions
ISO antimycin results in decreased phosphorylation of RPS6KB1 protein
oxophenylarsine inhibits the reaction [antimycin results in decreased phosphorylation of RPS6KB1 protein]
CTD PMID:16183647 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Sod2 superoxide dismutase 2 decreases response to substance ISO SOD2 protein results in decreased susceptibility to antimycin CTD PMID:10463952 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
antimycin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acox2 acyl-CoA oxidase 2 increases expression ISO Antimycin A results in increased expression of ACOX2 mRNA CTD PMID:19304788 NCBI chr15:18,449,304...18,481,472
Ensembl chr15:18,451,144...18,481,470
JBrowse link
G Akr1b7 aldo-keto reductase family 1, member B7 increases expression ISO Antimycin A results in increased expression of AKR1B7 mRNA CTD PMID:19304788 NCBI chr 4:61,850,256...61,879,733
Ensembl chr 4:61,850,348...61,862,526
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases activity
ISO Luteolin inhibits the reaction [Antimycin A results in decreased activity of AKT1 protein] CTD PMID:21466842, PMID:21782929 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Aldh1l2 aldehyde dehydrogenase 1 family, member L2 increases expression ISO Antimycin A results in increased expression of ALDH1L2 mRNA CTD PMID:19304788 NCBI chr 7:26,375,866...26,425,838
Ensembl chr 7:26,375,866...26,425,108
JBrowse link
G Angptl6 angiopoietin-like 6 increases expression ISO Antimycin A results in increased expression of ANGPTL6 mRNA CTD PMID:19304788 NCBI chr 8:21,895,523...21,902,002
Ensembl chr 8:21,895,524...21,901,829
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Antimycin A results in increased expression of ATF3 mRNA CTD PMID:19304788 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Atg13 autophagy related 13 multiple interactions ISO Antimycin A promotes the reaction [ATG13 protein results in increased expression of ULK1 protein]; ATG13 protein promotes the reaction [Antimycin A results in increased expression of ULK1 protein] CTD PMID:27629431 NCBI chr 3:80,580,549...80,614,554
Ensembl chr 3:80,581,247...80,601,410
JBrowse link
G Atp6v1h ATPase H+ transporting V1 subunit H multiple interactions ISO [PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of ATP6V1H mRNA CTD PMID:28366621 NCBI chr 5:14,262,352...14,367,898
Ensembl chr 5:14,262,349...14,367,898
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO [FOXO1 protein co-treated with FOXO4 protein co-treated with FOXO3 protein] affects the reaction [Resveratrol inhibits the reaction [Antimycin A results in increased expression of BAX protein]]; Resveratrol inhibits the reaction [Antimycin A results in increased expression of BAX protein] CTD PMID:24040102 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases response to substance
multiple interactions
ISO BCL2 protein results in decreased susceptibility to Antimycin A
PK 11195 inhibits the reaction [BCL2 protein results in decreased susceptibility to Antimycin A]
CTD PMID:12730627 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression
multiple interactions
ISO Antimycin A results in increased expression of BGLAP protein
sciadopitysin inhibits the reaction [Antimycin A results in increased expression of BGLAP protein]
CTD PMID:23624148 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression ISO Antimycin A results in increased expression of BNIP3 mRNA CTD PMID:19304788 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G Ca6 carbonic anhydrase 6 increases expression ISO Antimycin A results in increased expression of CAR6 mRNA CTD PMID:19304788 NCBI chr 5:167,226,246...167,244,786
Ensembl chr 5:167,226,246...167,244,786
JBrowse link
G Casp1 caspase 1 increases activity ISO Antimycin A results in increased activity of CASP1 protein CTD PMID:30582969 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp3 caspase 3 increases cleavage
increases activity
multiple interactions
ISO
EXP
Antimycin A results in increased cleavage of CASP3 protein
Antimycin A results in increased activity of CASP3 protein
NAD inhibits the reaction [Antimycin A results in increased cleavage of CASP3 protein]; Niacinamide promotes the reaction [Antimycin A results in increased cleavage of CASP3 protein]; Resveratrol inhibits the reaction [Antimycin A results in increased cleavage of CASP3 protein]; splitomicin promotes the reaction [Antimycin A results in increased cleavage of CASP3 protein]
CTD PMID:11078377, PMID:24040102 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Antimycin A results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 decreases expression ISO Antimycin A results in decreased expression of CCL3 protein CTD PMID:20116850 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO Antimycin A results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO Antimycin A results in decreased expression of CCL5 protein CTD PMID:20116850 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccna2 cyclin A2 decreases expression
multiple interactions
ISO Antimycin A results in decreased expression of CCNA2 mRNA; Antimycin A results in decreased expression of CCNA2 protein
Antimycin A inhibits the reaction [ELAVL1 protein binds to CCNA2 3' UTR]
CTD PMID:12730239 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 multiple interactions
decreases expression
ISO Antimycin A inhibits the reaction [ELAVL1 protein binds to CCNB1 3' UTR]
Antimycin A results in decreased expression of CCNB1 mRNA; Antimycin A results in decreased expression of CCNB1 protein
CTD PMID:12730239 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Cd14 CD14 molecule increases expression ISO Antimycin A results in increased expression of CD14 mRNA CTD PMID:10491287 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
JBrowse link
G Cd34 CD34 molecule decreases expression ISO Antimycin A results in decreased expression of CD34 mRNA CTD PMID:19304788 NCBI chr13:113,691,842...113,711,259
Ensembl chr13:113,691,932...113,711,647
JBrowse link
G Cd38 CD38 molecule increases expression ISO Antimycin A results in increased expression of CD38 mRNA CTD PMID:10491287 NCBI chr14:71,714,768...71,754,990
Ensembl chr14:71,715,269...71,754,672
JBrowse link
G Cd68 Cd68 molecule increases expression ISO Antimycin A results in increased expression of CD68 mRNA CTD PMID:19304788 NCBI chr10:56,268,726...56,270,605
Ensembl chr10:56,268,720...56,270,640
JBrowse link
G Chchd10 coiled-coil-helix-coiled-coil-helix domain containing 10 increases expression ISO Antimycin A results in increased expression of CHCHD10 mRNA CTD PMID:19304788 NCBI chr20:13,665,046...13,666,845
Ensembl chr20:13,665,031...13,667,333
JBrowse link
G Col16a1 collagen type XVI alpha 1 chain decreases expression ISO Antimycin A results in decreased expression of COL16A1 mRNA CTD PMID:19304788 NCBI chr 5:148,257,030...148,311,645
Ensembl chr 5:148,257,642...148,311,645
JBrowse link
G Cox6a2 cytochrome c oxidase subunit 6A2 increases expression ISO Antimycin A results in increased expression of COX6A2 mRNA CTD PMID:19304788 NCBI chr 1:199,624,037...199,626,255
Ensembl chr 1:199,624,037...199,624,783
JBrowse link
G Cp ceruloplasmin increases degradation
decreases expression
ISO Antimycin A results in increased degradation of CP mRNA
Antimycin A results in decreased expression of CP mRNA; Antimycin A results in decreased expression of CP protein
CTD PMID:19019832 NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
decreases phosphorylation
ISO 23-epi-26-deoxyactein inhibits the reaction [Antimycin A results in decreased phosphorylation of CREB1 protein]; acetovanillone inhibits the reaction [Antimycin A results in decreased phosphorylation of CREB1 protein] CTD PMID:21538410, PMID:22180388 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Cth cystathionine gamma-lyase increases expression ISO Antimycin A results in increased expression of CTH mRNA CTD PMID:19304788 NCBI chr 2:264,266,959...264,293,040
Ensembl chr 2:264,266,984...264,293,046
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO Antimycin A inhibits the reaction [TNF protein results in increased expression of CXCL1 mRNA] CTD PMID:24316229 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cycs cytochrome c, somatic multiple interactions
affects localization
ISO glabridin inhibits the reaction [Antimycin A affects the localization of CYCS protein] CTD PMID:21621525 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression EXP
ISO
Antimycin A results in increased expression of DDIT3 protein
Antimycin A results in increased expression of DDIT3 mRNA
CTD PMID:19304788, PMID:21337367 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G E2f7 E2F transcription factor 7 decreases expression ISO Antimycin A results in decreased expression of E2F7 mRNA CTD PMID:19304788 NCBI chr 7:53,275,659...53,318,261
Ensembl chr 7:53,275,676...53,316,481
JBrowse link
G Elavl1 ELAV like RNA binding protein 1 multiple interactions
decreases localization
ISO Antimycin A inhibits the reaction [ELAVL1 protein binds to CCNA2 3' UTR]; Antimycin A inhibits the reaction [ELAVL1 protein binds to CCNB1 3' UTR]
Antimycin A results in decreased localization of ELAVL1 protein
CTD PMID:12730239 NCBI chr12:2,461,502...2,502,432
Ensembl chr12:2,461,502...2,502,432
JBrowse link
G Entpd2 ectonucleoside triphosphate diphosphohydrolase 2 increases expression ISO Antimycin A results in increased expression of ENTPD2 mRNA CTD PMID:19304788 NCBI chr 3:2,617,795...2,623,818
Ensembl chr 3:2,617,805...2,623,445
JBrowse link
G Epas1 endothelial PAS domain protein 1 multiple interactions EXP Antimycin A inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein] CTD PMID:18353899 NCBI chr 6:10,306,508...10,385,239
Ensembl chr 6:10,306,405...10,387,265
JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha increases expression ISO Antimycin A results in increased expression of ERO1A mRNA CTD PMID:19304788 NCBI chr15:19,619,947...19,655,381
Ensembl chr15:19,619,973...19,655,381
JBrowse link
G Fas Fas cell surface death receptor decreases expression ISO Antimycin A results in decreased expression of FAS mRNA CTD PMID:8902626 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fgf1 fibroblast growth factor 1 decreases expression ISO Antimycin A results in decreased expression of FGF1 mRNA CTD PMID:19304788 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Foxo1 forkhead box O1 multiple interactions
decreases expression
ISO [Antimycin A co-treated with Resveratrol] results in decreased acetylation of FOXO1 protein; [FOXO1 protein co-treated with FOXO4 protein co-treated with FOXO3 protein] affects the reaction [Resveratrol inhibits the reaction [Antimycin A results in increased expression of BAX protein]]; FOXO1 mutant form affects the reaction [[Antimycin A co-treated with Resveratrol] affects the expression of SOD2 mRNA]; FOXO1 mutant form affects the reaction [[Antimycin A co-treated with Resveratrol] affects the expression of SOD2 protein]
Antimycin A results in decreased expression of FOXO1 protein
CTD PMID:24040102 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
G Foxo3 forkhead box O3 decreases expression
multiple interactions
ISO Antimycin A results in decreased expression of FOXO3 protein
[FOXO1 protein co-treated with FOXO4 protein co-treated with FOXO3 protein] affects the reaction [Resveratrol inhibits the reaction [Antimycin A results in increased expression of BAX protein]]; FOXO3 mutant form affects the reaction [[Antimycin A co-treated with Resveratrol] affects the expression of SOD2 mRNA]; FOXO3 mutant form affects the reaction [[Antimycin A co-treated with Resveratrol] affects the expression of SOD2 protein]
CTD PMID:24040102 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
JBrowse link
G Foxo4 forkhead box O4 multiple interactions
decreases expression
ISO [FOXO1 protein co-treated with FOXO4 protein co-treated with FOXO3 protein] affects the reaction [Resveratrol inhibits the reaction [Antimycin A results in increased expression of BAX protein]]; FOXO4 mutant form affects the reaction [[Antimycin A co-treated with Resveratrol] affects the expression of SOD2 mRNA]; FOXO4 mutant form affects the reaction [[Antimycin A co-treated with Resveratrol] affects the expression of SOD2 protein]
Antimycin A results in decreased expression of FOXO4 protein
CTD PMID:24040102 NCBI chr  X:71,155,284...71,162,158
Ensembl chr  X:71,155,601...71,162,158
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO Antimycin A results in increased expression of GADD45A mRNA CTD PMID:19304788 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gch1 GTP cyclohydrolase 1 increases expression ISO Antimycin A results in increased expression of GCH1 mRNA CTD PMID:19304788 NCBI chr15:23,935,011...23,968,971
Ensembl chr15:23,934,585...23,969,011
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression ISO Antimycin A results in increased expression of GSTA2 mRNA CTD PMID:19304788 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases expression ISO Antimycin A results in increased expression of GSTA1 mRNA CTD PMID:19304788 NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179
JBrowse link
G Gsta6 glutathione S-transferase alpha 6 increases expression ISO Antimycin A results in increased expression of GSTA2 mRNA CTD PMID:19304788 NCBI chr 9:27,475,273...27,533,939
Ensembl chr 9:27,475,273...27,511,176
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha affects expression EXP Antimycin A affects the expression of HIF1A protein CTD PMID:16034640 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression EXP Antimycin A results in increased expression of HSPA5 protein CTD PMID:21337367 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Htra1 HtrA serine peptidase 1 increases expression ISO Antimycin A results in increased expression of HTRA1 mRNA CTD PMID:19304788 NCBI chr 1:201,499,067...201,548,508
Ensembl chr 1:201,499,028...201,548,513
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression
multiple interactions
ISO Antimycin A results in decreased expression of ICAM1 mRNA
Antimycin A inhibits the reaction [N-caproylsphingosine results in increased expression of ICAM1 mRNA]
CTD PMID:12952965, PMID:19304788 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Acetylcysteine inhibits the reaction [[Antimycin A co-treated with IL1B protein] results in increased expression of CXCL8 protein]; Antimycin A promotes the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; Antimycin A promotes the reaction [IL1B protein results in increased expression of CXCL8 protein]; Antimycin A promotes the reaction [IL1B protein results in increased expression of PTGS2 protein]; BAY 11-7085 inhibits the reaction [[Antimycin A co-treated with IL1B protein] results in increased expression of CXCL8 protein]; IL1B protein promotes the reaction [Antimycin A results in increased expression of PTGS2 protein]; Resveratrol inhibits the reaction [[Antimycin A co-treated with IL1B protein] results in increased expression of CXCL8 protein] CTD PMID:22549761, PMID:24609059 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Antimycin A results in increased expression of and results in increased secretion of IL6 protein]; 23-epi-26-deoxyactein inhibits the reaction [Antimycin A results in increased expression of IL6 protein]; 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Antimycin A results in increased expression of and results in increased secretion of IL6 protein]; Antimycin A results in increased expression of and results in increased secretion of IL6 protein; Cyclosporine inhibits the reaction [Antimycin A results in increased expression of and results in increased secretion of IL6 protein] CTD PMID:21381053, PMID:21910134 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO Antimycin A results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:189,196,180...189,255,987
Ensembl chr 2:189,205,701...189,254,628
JBrowse link
G Itgb7 integrin subunit beta 7 increases expression ISO Antimycin A results in increased expression of ITGB7 mRNA CTD PMID:19304788 NCBI chr 7:143,820,236...143,837,802
Ensembl chr 7:143,820,900...143,837,780
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO [Antimycin A co-treated with Paraquat] results in increased expression of JUN protein
Antimycin A results in increased expression of JUN protein
CTD PMID:16237197 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 multiple interactions ISO [PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of LAMP1 mRNA CTD PMID:28366621 NCBI chr16:81,689,576...81,714,341
Ensembl chr16:81,689,335...81,714,419
JBrowse link
G Lsm6 LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated decreases expression ISO Antimycin A results in decreased expression of LSM6 mRNA CTD PMID:19304788 NCBI chr19:32,770,640...32,785,215
Ensembl chr19:32,770,655...32,785,215
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO Antimycin A inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK14 protein] CTD PMID:15650392 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mmp13 matrix metallopeptidase 13 increases expression ISO Antimycin A results in increased expression of MMP13 mRNA CTD PMID:19304788 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
increases activity
ISO [Antimycin A results in increased abundance of Reactive Oxygen Species] which results in increased activity of MMP2 protein
Antimycin A results in increased activity of MMP2 protein
CTD PMID:11929863 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Ndrg1 N-myc downstream regulated 1 increases expression ISO Antimycin A results in increased expression of NDRG1 mRNA CTD PMID:19304788 NCBI chr 7:107,734,326...107,775,701
Ensembl chr 7:107,734,323...107,775,714
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Antimycin A inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein] CTD PMID:24316229 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nrp1 neuropilin 1 decreases expression ISO Antimycin A results in decreased expression of NRP1 mRNA CTD PMID:19304788 NCBI chr19:61,332,351...61,486,166
Ensembl chr19:61,332,351...61,485,858
JBrowse link
G Nt5e 5' nucleotidase, ecto increases expression ISO Antimycin A results in increased expression of NT5E mRNA CTD PMID:19304788 NCBI chr 8:95,969,002...96,012,733
Ensembl chr 8:95,968,652...96,012,696
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Antimycin A results in increased expression of NUPR1 mRNA CTD PMID:19304788 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO Antimycin A results in increased cleavage of PARP1 protein
[Antimycin A co-treated with Paraquat] results in increased cleavage of PARP1 protein
CTD PMID:16237197 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions ISO [PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of ATP6V1H mRNA; [PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of LAMP1 mRNA; [PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of TFEB mRNA; PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] affects the localization of PRKN protein]; PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] affects the localization of TFEB protein]; PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] results in increased expression of SQSTM1 mRNA]; PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]; Trifluoperazine affects the reaction [PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] affects the localization of TFEB protein]] CTD PMID:28366621 NCBI chr 5:156,677,146...156,689,258
Ensembl chr 5:156,677,146...156,689,415
JBrowse link
G Ppl periplakin decreases expression ISO Antimycin A results in decreased expression of PPL mRNA CTD PMID:19304788 NCBI chr10:10,644,572...10,690,223
Ensembl chr10:10,644,572...10,690,223
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO Antimycin A results in increased expression of PPP1R15A mRNA CTD PMID:19304788 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions ISO [oligomycin A co-treated with Antimycin A] affects the localization of PRKN protein; [Oligomycins co-treated with Antimycin A] affects the localization of PRKN protein; PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] affects the localization of PRKN protein] CTD PMID:28366621, PMID:28673964 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO Antimycin A results in increased expression of PTGS2 protein
Antimycin A results in increased expression of PTGS2 mRNA
Antimycin A promotes the reaction [IL1B protein results in increased expression of PTGS2 protein]; IL1B protein promotes the reaction [Antimycin A results in increased expression of PTGS2 protein]
CTD PMID:19304788, PMID:24609059 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rbl1 RB transcriptional corepressor like 1 decreases expression ISO Antimycin A results in decreased expression of RBL1 mRNA CTD PMID:19304788 NCBI chr 3:153,263,692...153,321,351
Ensembl chr 3:153,263,692...153,321,352
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization
multiple interactions
ISO Antimycin A affects the localization of RELA protein
Antimycin A inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]
CTD PMID:24316229, PMID:24609059 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rnd1 Rho family GTPase 1 increases expression ISO Antimycin A results in increased expression of RND1 mRNA CTD PMID:19304788 NCBI chr 7:140,349,138...140,356,209
Ensembl chr 7:140,349,138...140,356,209
JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 decreases expression ISO Antimycin A results in decreased expression of RRM2 mRNA CTD PMID:19304788 NCBI chr 6:43,884,627...43,890,818
Ensembl chr 6:43,884,678...43,889,515
JBrowse link
G Snai2 snail family transcriptional repressor 2 increases expression ISO Antimycin A results in increased expression of SNAI2 mRNA CTD PMID:19304788 NCBI chr11:90,404,421...90,406,730
Ensembl chr11:90,403,333...90,406,797
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression
ISO
EXP
Antimycin A inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]
[Antimycin A co-treated with Resveratrol] affects the expression of SOD2 mRNA; [Antimycin A co-treated with Resveratrol] affects the expression of SOD2 protein; FOXO1 mutant form affects the reaction [[Antimycin A co-treated with Resveratrol] affects the expression of SOD2 mRNA]; FOXO1 mutant form affects the reaction [[Antimycin A co-treated with Resveratrol] affects the expression of SOD2 protein]; FOXO3 mutant form affects the reaction [[Antimycin A co-treated with Resveratrol] affects the expression of SOD2 mRNA]; FOXO3 mutant form affects the reaction [[Antimycin A co-treated with Resveratrol] affects the expression of SOD2 protein]; FOXO4 mutant form affects the reaction [[Antimycin A co-treated with Resveratrol] affects the expression of SOD2 mRNA]; FOXO4 mutant form affects the reaction [[Antimycin A co-treated with Resveratrol] affects the expression of SOD2 protein]
Antimycin A inhibits the reaction [Lipopolysaccharides results in increased expression of SOD2 mRNA]
Antimycin A results in increased expression of SOD2 protein
CTD PMID:11264281, PMID:22718889, PMID:24040102 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sqstm1 sequestosome 1 increases expression
multiple interactions
ISO Antimycin A results in increased expression of SQSTM1 mRNA
[oligomycin A co-treated with Antimycin A] results in increased expression of SQSTM1 mRNA; PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] results in increased expression of SQSTM1 mRNA]
CTD PMID:19304788, PMID:28366621 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Star steroidogenic acute regulatory protein decreases expression ISO Antimycin A results in decreased expression of STAR protein CTD PMID:16469751 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Tfeb transcription factor EB multiple interactions ISO [oligomycin A co-treated with Antimycin A] affects the localization of TFEB protein; [PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of TFEB mRNA; PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] affects the localization of TFEB protein]; Trifluoperazine affects the reaction [PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] affects the localization of TFEB protein]] CTD PMID:28366621 NCBI chr 9:15,208,141...15,264,101
Ensembl chr 9:15,207,822...15,214,596
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
ISO Antimycin A results in increased expression of TNF protein
Antimycin A inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; Antimycin A promotes the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Antimycin A promotes the reaction [TNF protein results in increased expression of CXCL8 protein]
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Antimycin A results in increased expression of and results in increased secretion of TNF protein]; 23-epi-26-deoxyactein inhibits the reaction [Antimycin A results in increased expression of TNF protein]; 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Antimycin A results in increased expression of and results in increased secretion of TNF protein]; Antimycin A inhibits the reaction [TNF protein results in increased expression of CXCL1 mRNA]; Antimycin A inhibits the reaction [TNF protein results in increased expression of TNFAIP3 mRNA]; Antimycin A inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; Antimycin A inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]; Antimycin A results in increased expression of and results in increased secretion of TNF protein; Cyclosporine inhibits the reaction [Antimycin A results in increased expression of and results in increased secretion of TNF protein]; sciadopitysin inhibits the reaction [Antimycin A results in increased expression of TNF protein]
CTD PMID:11264281, PMID:21381053, PMID:21910134, PMID:22549761, PMID:23624148, PMID:24316229 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 multiple interactions ISO Antimycin A inhibits the reaction [TNF protein results in increased expression of TNFAIP3 mRNA] CTD PMID:24316229 NCBI chr 1:14,401,103...14,416,369
Ensembl chr 1:14,402,913...14,412,807
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B decreases expression ISO Antimycin A results in decreased expression of TNFRSF11B protein CTD PMID:21381053 NCBI chr 7:93,798,580...93,826,586
Ensembl chr 7:93,798,545...93,826,665
JBrowse link
G Tnfsf11 TNF superfamily member 11 increases expression
multiple interactions
ISO Antimycin A results in increased expression of TNFSF11 protein
23-epi-26-deoxyactein inhibits the reaction [Antimycin A results in increased expression of TNFSF11 protein]; 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Antimycin A results in increased expression of TNFSF11 protein]
CTD PMID:21381053, PMID:21910134 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
G Tnxb tenascin XB decreases expression ISO Antimycin A results in decreased expression of TNXB mRNA CTD PMID:19304788
G Tp53 tumor protein p53 multiple interactions
increases response to substance
increases acetylation
ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [Antimycin A results in increased acetylation of TRP53 protein]; Resveratrol inhibits the reaction [Antimycin A results in increased acetylation of TRP53 protein]
TRP53 protein results in increased susceptibility to Antimycin A
CTD PMID:24040102 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression ISO Antimycin A results in increased expression of TRIB3 mRNA CTD PMID:19304788 NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571
JBrowse link
G Trip12 thyroid hormone receptor interactor 12 decreases expression ISO Antimycin A results in decreased expression of TRIP12 mRNA CTD PMID:19304788 NCBI chr 9:92,305,059...92,435,388
Ensembl chr 9:92,305,051...92,435,365
JBrowse link
G Tshz2 teashirt zinc finger homeobox 2 decreases expression ISO Antimycin A results in decreased expression of TSHZ2 mRNA CTD PMID:19304788 NCBI chr 3:166,469,752...166,748,558
Ensembl chr 3:166,743,544...166,746,597
JBrowse link
G Ucp2 uncoupling protein 2 increases expression ISO Antimycin A results in increased expression of UCP2 protein CTD PMID:18082129 NCBI chr 1:165,506,375...165,512,744
Ensembl chr 1:165,506,361...165,512,744
JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 increases expression
multiple interactions
ISO Antimycin A results in increased expression of ULK1 mRNA; Antimycin A results in increased expression of ULK1 protein
Antimycin A inhibits the reaction [Cycloheximide results in decreased expression of ULK1 protein]; Antimycin A inhibits the reaction [Nitrogen deficiency results in decreased expression of ULK1 protein]; Antimycin A promotes the reaction [ATG13 protein results in increased expression of ULK1 protein]; ATG13 protein promotes the reaction [Antimycin A results in increased expression of ULK1 protein]; Cycloheximide inhibits the reaction [Antimycin A results in increased expression of ULK1 protein]; Nitrogen deficiency inhibits the reaction [Antimycin A results in increased expression of ULK1 protein]
CTD PMID:27629431 NCBI chr12:51,908,105...51,934,704
Ensembl chr12:51,908,448...51,934,702
JBrowse link
G Uts2 urotensin 2 increases expression ISO Antimycin A results in increased expression of UTS2 mRNA CTD PMID:19304788 NCBI chr 5:168,078,748...168,084,133
Ensembl chr 5:168,078,748...168,084,145
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Antimycin A results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Wnt7a Wnt family member 7A increases expression ISO Antimycin A results in increased expression of WNT7A mRNA CTD PMID:19304788 NCBI chr 4:122,994,425...123,040,609
Ensembl chr 4:122,994,425...123,040,609
JBrowse link
G Xbp1 X-box binding protein 1 increases expression EXP Antimycin A results in increased expression of XBP1 protein CTD PMID:21337367 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
G Zhx1 zinc fingers and homeoboxes 1 decreases expression ISO Antimycin A results in decreased expression of ZHX1 mRNA CTD PMID:19304788 NCBI chr 7:97,915,280...97,944,787
Ensembl chr 7:97,915,581...97,944,491
JBrowse link
ascomycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fkbp1a FKBP prolyl isomerase 1A multiple interactions ISO
EXP
immunomycin inhibits the reaction [Sirolimus binds to FKBP1A protein] CTD PMID:7503980, PMID:7532117 NCBI chr 3:147,042,944...147,062,725
Ensembl chr 3:147,042,944...147,062,724
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions EXP
ISO
[Okadaic Acid co-treated with immunomycin] results in increased phosphorylation of MAPT protein CTD PMID:7723735 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
avermectin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases response to substance
affects response to substance
increases response to substance
ISO ABCB1A protein results in decreased susceptibility to avermectin
ABCB1A protein affects the susceptibility to avermectin
ABCB1A gene mutant form results in increased susceptibility to avermectin
CTD PMID:9144452, PMID:10562306, PMID:22834856 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 decreases activity EXP avermectin results in decreased activity of GABRB2 protein CTD PMID:10841270 NCBI chr10:27,973,694...28,193,072
Ensembl chr10:27,973,681...28,187,565
JBrowse link
azithromycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arg1 arginase 1 increases expression ISO Azithromycin results in increased expression of ARG1 protein CTD PMID:20231397 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
JBrowse link
G Arsa arylsulfatase A increases activity EXP Azithromycin results in increased activity of ARSA protein CTD PMID:8830663 NCBI chr 7:130,446,644...130,452,632
Ensembl chr 7:130,446,668...130,451,283
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Azithromycin results in decreased expression of CCL2 protein CTD PMID:20231397 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ctsb cathepsin B multiple interactions
increases activity
EXP Cycloheximide inhibits the reaction [Azithromycin results in increased activity of CTSB protein] CTD PMID:8830663 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Azithromycin results in increased expression of FOS mRNA; Azithromycin results in increased expression of FOS protein CTD PMID:32454074 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Hexb hexosaminidase subunit beta increases activity EXP Azithromycin results in increased activity of HEXB protein CTD PMID:8830663 NCBI chr 2:27,983,925...28,003,260
Ensembl chr 2:27,984,117...28,003,186
JBrowse link
G Il1b interleukin 1 beta decreases expression
multiple interactions
ISO Azithromycin results in decreased expression of IL1B protein
Azithromycin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Azithromycin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]
CTD PMID:18435685, PMID:21195124 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 decreases expression ISO Azithromycin results in decreased expression of IL6 protein CTD PMID:20231397 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mmp1 matrix metallopeptidase 1 increases secretion
decreases secretion
ISO Azithromycin results in increased secretion of MMP1 protein
Azithromycin results in decreased secretion of MMP1 protein
CTD PMID:24890593 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mmp3 matrix metallopeptidase 3 increases secretion
decreases secretion
ISO Azithromycin results in increased secretion of MMP3 protein
Azithromycin results in decreased secretion of MMP3 protein
CTD PMID:24890593 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
JBrowse link
G Pla1a phospholipase A1 member A increases activity EXP Azithromycin results in increased activity of PLA1A protein CTD PMID:8830663 NCBI chr11:64,882,024...64,919,714
Ensembl chr11:64,882,288...64,919,579
JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions ISO Azithromycin inhibits the reaction [Lipopolysaccharides results in increased activity of RAC1 protein] CTD PMID:21417583 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Azithromycin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Tnf tumor necrosis factor decreases expression ISO Azithromycin results in decreased expression of TNF protein CTD PMID:20231397 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
bafilomycin A1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen multiple interactions EXP bafilomycin A1 inhibits the reaction [AGT protein affects the localization of Calcium] CTD PMID:21613610 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Aim2 absent in melanoma 2 multiple interactions ISO [bafilomycin A1 co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of AIM2 protein CTD PMID:32645460 NCBI chr13:91,919,834...91,963,080
Ensembl chr13:91,954,138...91,962,588
JBrowse link
G Akt1s1 AKT1 substrate 1 multiple interactions EXP bafilomycin A1 inhibits the reaction [EGF protein results in increased phosphorylation of AKT1S1 protein] CTD PMID:22689575 NCBI chr 1:100,845,443...100,851,961
Ensembl chr 1:100,845,563...100,851,960
JBrowse link
G Alb albumin decreases uptake ISO bafilomycin A1 results in decreased uptake of ALB protein CTD PMID:16313995 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO bafilomycin A1 results in increased expression of APAF1 protein CTD PMID:28483490 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
JBrowse link
G Appl1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 multiple interactions ISO bafilomycin A1 promotes the reaction [Lipopolysaccharides results in increased degradation of APPL1 protein]; bafilomycin A1 promotes the reaction [Poly I-C results in increased degradation of APPL1 protein] CTD PMID:25780039 NCBI chr16:2,560,103...2,602,035
Ensembl chr16:2,563,520...2,602,103
JBrowse link
G Asic1 acid sensing ion channel subunit 1 multiple interactions ISO bafilomycin A1 inhibits the reaction [Freund's Adjuvant results in increased expression of ASIC1 mRNA] CTD PMID:16769263 NCBI chr 7:141,324,714...141,354,937
Ensembl chr 7:141,326,321...141,354,937
JBrowse link
G Atg5 autophagy related 5 multiple interactions ISO ATG5 protein affects the reaction [bafilomycin A1 promotes the reaction [gossypol acetic acid results in increased expression of MAP1LC3B protein modified form]] CTD PMID:29938581 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO bafilomycin A1 inhibits the reaction [Hydroxychloroquine results in increased activity of BAX protein] CTD PMID:12813466 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO bafilomycin A1 results in decreased expression of BCL2 mRNA CTD PMID:31310755 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Becn1 beclin 1 multiple interactions ISO bafilomycin A1 inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of BECN1 protein] CTD PMID:32645460 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions ISO bafilomycin A1 inhibits the reaction [[Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] results in increased expression of BGLAP mRNA] CTD PMID:23111315 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions
increases cleavage
increases expression
EXP
ISO
bafilomycin A1 inhibits the reaction [manganese chloride results in increased expression of BID protein modified form]; bafilomycin A1 inhibits the reaction [manganese chloride results in increased expression of BID protein]
vistusertib affects the reaction [bafilomycin A1 results in increased cleavage of BID protein]
bafilomycin A1 results in increased expression of BID protein modified form
CTD PMID:26853465, PMID:28378122 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression
multiple interactions
ISO bafilomycin A1 results in increased expression of BNIP3 mRNA; bafilomycin A1 results in increased expression of BNIP3 protein
BNIP3 mutant form promotes the reaction [bafilomycin A1 results in increased cleavage of PARP1 protein]; capivasertib affects the reaction [bafilomycin A1 results in increased expression of BNIP3 protein]; Erlotinib Hydrochloride inhibits the reaction [bafilomycin A1 results in increased expression of BNIP3 protein]; Gefitinib inhibits the reaction [bafilomycin A1 results in increased expression of BNIP3 protein]; HIF1A mutant form inhibits the reaction [bafilomycin A1 results in increased expression of BNIP3 mRNA]; Lapatinib inhibits the reaction [bafilomycin A1 results in increased expression of BNIP3 mRNA]; vistusertib inhibits the reaction [bafilomycin A1 results in increased expression of BNIP3 protein]
CTD PMID:25981168, PMID:26853465 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G C1qtnf9 C1q and TNF related 9 multiple interactions EXP bafilomycin A1 promotes the reaction [C1QTNF9 protein results in increased expression of MAP1LC3B protein modified form] CTD PMID:32278738 NCBI chr15:41,069,579...41,080,961
Ensembl chr15:41,069,507...41,081,159
JBrowse link
G Casp3 caspase 3 decreases activity
increases cleavage
multiple interactions
increases activity
ISO
EXP
bafilomycin A1 results in decreased activity of CASP3 protein
bafilomycin A1 results in increased cleavage of CASP3 protein
bafilomycin A1 inhibits the reaction [Cadmium results in increased cleavage of CASP3 protein]
bafilomycin A1 results in increased activity of CASP3 protein
bafilomycin A1 inhibits the reaction [manganese chloride results in increased cleavage of CASP3 protein]; bafilomycin A1 promotes the reaction [Hydrogen Peroxide results in increased expression of CASP3 protein modified form]
[bafilomycin A1 co-treated with cobaltous chloride co-treated with TP53 gene mutant form] results in increased activity of CASP3 protein; bafilomycin A1 inhibits the reaction [Soot analog results in increased expression of CASP3 protein]; bafilomycin A1 inhibits the reaction [tetrandrine results in increased cleavage of CASP3 protein]; bafilomycin A1 promotes the reaction [Atorvastatin results in increased cleavage of CASP3 protein]; bafilomycin A1 promotes the reaction [brazilin results in increased activity of CASP3 protein]; bafilomycin A1 promotes the reaction [fosbretabulin results in increased cleavage of CASP3 protein]; vistusertib affects the reaction [bafilomycin A1 results in increased cleavage of CASP3 protein]
CTD PMID:20876807, PMID:23380477, PMID:24321340, PMID:24889822, PMID:25266202, PMID:25981168, PMID:26853465, PMID:28063998, PMID:28378122, PMID:29111403, PMID:30240709 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp4 caspase 4 increases activity ISO bafilomycin A1 results in increased activity of CASP4 protein CTD PMID:20371669 NCBI chr 8:2,616,391...2,651,682
Ensembl chr 8:2,635,851...2,651,652
JBrowse link
G Casp7 caspase 7 increases activity
decreases activity
ISO bafilomycin A1 results in increased activity of CASP7 protein
bafilomycin A1 results in decreased activity of CASP7 protein
CTD PMID:20371669, PMID:25981168 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 multiple interactions EXP
ISO
bafilomycin A1 inhibits the reaction [manganese chloride results in increased cleavage of CASP8 protein]
bafilomycin A1 inhibits the reaction [Cadmium results in increased cleavage of CASP8 protein]
CTD PMID:28378122, PMID:29111403 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions EXP
ISO
bafilomycin A1 inhibits the reaction [manganese chloride results in increased cleavage of CASP9 protein]
bafilomycin A1 inhibits the reaction [Soot analog results in increased expression of CASP9 protein]
CTD PMID:28378122, PMID:30240709 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cdc25c cell division cycle 25C multiple interactions ISO bafilomycin A1 inhibits the reaction [xanthatin results in decreased stability of CDC25C protein] CTD PMID:29074359 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
JBrowse link
G Ctsb cathepsin B multiple interactions ISO bafilomycin A1 inhibits the reaction [[cobaltous chloride co-treated with TP53 gene mutant form] results in increased activity of CTSB protein]; bafilomycin A1 inhibits the reaction [Hydroxychloroquine affects the localization of CTSB protein] CTD PMID:12813466, PMID:23380477 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO bafilomycin A1 inhibits the reaction [CpG ODN 2216 results in increased expression of CXCL10 protein]; bafilomycin A1 inhibits the reaction [gardiquimod results in increased expression of CXCL10 protein]; bafilomycin A1 inhibits the reaction [Poly I-C results in increased expression of CXCL10 protein] CTD PMID:26682054 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression
multiple interactions
EXP bafilomycin A1 results in increased expression of DDIT4 protein
[EGF protein co-treated with bafilomycin A1] results in increased expression of DDIT4 protein
CTD PMID:22689575 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382
JBrowse link
G Egf epidermal growth factor multiple interactions EXP [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Arginine; [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Asparagine; [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Isoleucine; [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Leucine; [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Lysine; [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Methionine; [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Ornithine; [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Phenylalanine; [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Tyrosine; [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Valine; [bafilomycin A1 co-treated with EGF protein] results in increased abundance of Aspartic Acid; [bafilomycin A1 co-treated with EGF protein] results in increased abundance of Taurine; [EGF protein co-treated with bafilomycin A1] results in increased expression of DDIT4 protein; bafilomycin A1 inhibits the reaction [EGF protein results in increased activity of and results in increased phosphorylation of RPS6KB1 protein]; bafilomycin A1 inhibits the reaction [EGF protein results in increased phosphorylation of AKT1S1 protein]; bafilomycin A1 inhibits the reaction [EGF protein results in increased phosphorylation of EIF4EBP1 protein]; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Arginine]; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Asparagine]; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Isoleucine]; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Leucine]; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Lysine]; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Methionine]; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Ornithine]; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Phenylalanine]; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Tyrosine]; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Valine] CTD PMID:22689575 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO bafilomycin A1 inhibits the reaction [Arsenic Trioxide results in decreased expression of EGFR protein] CTD PMID:30237564 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions EXP bafilomycin A1 inhibits the reaction [EGF protein results in increased phosphorylation of EIF4EBP1 protein]; bafilomycin A1 inhibits the reaction [INS protein results in increased phosphorylation of EIF4EBP1 protein] CTD PMID:22689575 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Epor erythropoietin receptor multiple interactions ISO bafilomycin A1 inhibits the reaction [Aristolochic Acids results in increased degradation of and results in decreased expression of EPOR protein] CTD PMID:26136230 NCBI chr 8:22,969,737...22,974,468
Ensembl chr 8:22,969,745...22,974,321
JBrowse link
G Faslg Fas ligand multiple interactions ISO
EXP
bafilomycin A1 inhibits the reaction [FASL protein affects the localization of Calcium]
bafilomycin A1 inhibits the reaction [manganese chloride results in increased expression of FASLG protein]
CTD PMID:20200208, PMID:28378122 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fmc1 formation of mitochondrial complex V assembly factor 1 multiple interactions ISO bafilomycin A1 inhibits the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of FMC1 protein] CTD PMID:29371327 NCBI chr 4:66,276,835...66,284,868
Ensembl chr 4:66,276,835...66,284,868
JBrowse link
G Foxo1 forkhead box O1 multiple interactions EXP bafilomycin A1 inhibits the reaction [resveratrol inhibits the reaction [Hydrogen Peroxide results in increased acetylation of FOXO1 protein]] CTD PMID:24889822 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression
multiple interactions
ISO bafilomycin A1 results in increased expression of HIF1A protein
HIF1A mutant form inhibits the reaction [bafilomycin A1 results in increased expression of BNIP3 mRNA]; HIF1A mutant form promotes the reaction [bafilomycin A1 results in increased cleavage of PARP1 protein]; lapatinib inhibits the reaction [bafilomycin A1 results in increased expression of HIF1A protein]
CTD PMID:25981168 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmox1 heme oxygenase 1 decreases expression
multiple interactions
ISO bafilomycin A1 results in decreased expression of HMOX1 protein
bafilomycin A1 inhibits the reaction [4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole results in increased expression of HMOX1 protein]
CTD PMID:29796178 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Ifng interferon gamma decreases expression ISO bafilomycin A1 results in decreased expression of IFNG mRNA CTD PMID:16932910 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il1b interleukin 1 beta decreases expression
multiple interactions
ISO bafilomycin A1 results in decreased expression of IL1B mRNA
[bafilomycin A1 co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of IL1B protein; bafilomycin A1 inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with aluminum sulfate] results in increased secretion of IL1B protein]
CTD PMID:16932910, PMID:24158569, PMID:32645460 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 increases expression ISO bafilomycin A1 results in increased expression of IL6 mRNA CTD PMID:16932910 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ins2 insulin 2 multiple interactions EXP
ISO
bafilomycin A1 inhibits the reaction [INS protein results in increased phosphorylation of EIF4EBP1 protein]; bafilomycin A1 inhibits the reaction [INS protein results in increased phosphorylation of RPS6KB1 protein]
bafilomycin A1 promotes the reaction [Palmitic Acid inhibits the reaction [INS1 protein results in increased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose]]
CTD PMID:22689575, PMID:32283200 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 increases response to substance ISO LRRK2 gene mutant form results in increased susceptibility to bafilomycin A1 CTD PMID:25017139 NCBI chr 7:132,857,311...133,018,549
Ensembl chr 7:132,857,628...133,018,584
JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha multiple interactions
increases expression
ISO bafilomycin A1 promotes the reaction [Uranium results in increased expression of MAP1LC3A protein]
bafilomycin A1 results in increased expression of MAP1LC3A protein modified form
CTD PMID:30871063, PMID:31120128 NCBI chr 3:150,801,289...150,802,935
Ensembl chr 3:150,801,289...150,802,935
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases lipidation
increases expression
increases cleavage
decreases degradation
ISO
EXP
[di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone co-treated with bafilomycin A1] results in increased expression of MAP1LC3B mRNA; [TNF protein co-treated with bafilomycin A1] results in increased expression of MAP1LC3B protein alternative form; Acetylcysteine inhibits the reaction [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone promotes the reaction [bafilomycin A1 results in increased expression of MAP1LC3B protein]]; ATG5 protein affects the reaction [bafilomycin A1 promotes the reaction [gossypol acetic acid results in increased expression of MAP1LC3B protein modified form]]; bafilomycin A1 affects the reaction [Ammonium Chloride results in increased metabolism of MAP1LC3B protein]; bafilomycin A1 affects the reaction [AZD4547 affects the expression of MAP1LC3B protein modified form]; bafilomycin A1 affects the reaction [AZD8186 affects the expression of MAP1LC3B protein modified form]; bafilomycin A1 inhibits the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]; bafilomycin A1 promotes the reaction [capivasertib results in increased expression of MAP1LC3B protein modified form]; bafilomycin A1 promotes the reaction [gossypol acetic acid results in increased expression of MAP1LC3B protein modified form]; bafilomycin A1 promotes the reaction [Resveratrol results in increased expression of MAP1LC3B protein alternative form]; bafilomycin A1 promotes the reaction [vistusertib results in increased expression of MAP1LC3B protein modified form]; di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone promotes the reaction [bafilomycin A1 results in increased expression of MAP1LC3B protein]; Resveratrol promotes the reaction [[TNF protein co-treated with bafilomycin A1] results in increased expression of MAP1LC3B protein alternative form]
bafilomycin A1 results in increased lipidation of MAP1LC3B protein
[Doxorubicin co-treated with bafilomycin A1] results in increased expression of MAP1LC3B protein; [Glycyrrhizic Acid co-treated with bafilomycin A1] results in increased lipidation of MAP1LC3B protein; bafilomycin A1 promotes the reaction [C1QTNF9 protein results in increased expression of MAP1LC3B protein modified form]
bafilomycin A1 results in increased expression of MAP1LC3B protein modified form
bafilomycin A1 promotes the reaction [Triiodothyronine results in increased lipidation of MAP1LC3B protein]; Triiodothyronine promotes the reaction [bafilomycin A1 results in increased lipidation of MAP1LC3B protein]
bafilomycin A1 results in increased cleavage of MAP1LC3B protein
bafilomycin A1 results in decreased degradation of MAP1LC3B protein modified form
bafilomycin A1 results in increased expression of MAP1LC3B protein; bafilomycin A1 results in increased expression of MAP1LC3B protein alternative form; bafilomycin A1 results in increased expression of MAP1LC3B protein modified form
CTD PMID:23880069, PMID:24145604, PMID:25301941, PMID:26459185, PMID:26853465, PMID:29248574, PMID:29524503, PMID:29908302, PMID:29938581, PMID:30209975, PMID:31310755, PMID:32278738, PMID:32525084 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases expression
ISO bafilomycin A1 inhibits the reaction [Capsaicin results in increased activity of MAPK1 protein]; bafilomycin A1 inhibits the reaction [Iron Compounds results in increased expression of MAPK1 protein modified form]; bafilomycin A1 promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of MAPK1 protein]
bafilomycin A1 results in increased expression of MAPK1 protein modified form
CTD PMID:20371669, PMID:28483490, PMID:32645460 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases expression
ISO bafilomycin A1 inhibits the reaction [Capsaicin results in increased activity of MAPK3 protein]; bafilomycin A1 inhibits the reaction [Iron Compounds results in increased expression of MAPK3 protein modified form]; bafilomycin A1 promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of MAPK3 protein]
bafilomycin A1 results in increased expression of MAPK3 protein modified form
CTD PMID:20371669, PMID:28483490, PMID:32645460 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO bafilomycin A1 results in increased phosphorylation of MAPK8 protein CTD PMID:31310755 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO bafilomycin A1 results in decreased phosphorylation of MTOR protein CTD PMID:31310755 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Ndrg1 N-myc downstream regulated 1 multiple interactions ISO NDRG1 protein results in decreased susceptibility to [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone co-treated with bafilomycin A1] CTD PMID:24532803 NCBI chr 7:107,734,326...107,775,701
Ensembl chr 7:107,734,323...107,775,714
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases expression
ISO bafilomycin A1 promotes the reaction [[Particulate Matter co-treated with Vitamin D] results in increased expression of NFE2L2 protein]; bafilomycin A1 promotes the reaction [[Silicon Dioxide co-treated with Vitamin D] results in increased expression of NFE2L2 protein]; bafilomycin A1 promotes the reaction [Particulate Matter results in increased expression of NFE2L2 protein]; bafilomycin A1 promotes the reaction [Silicon Dioxide results in increased expression of NFE2L2 protein]
bafilomycin A1 results in increased expression of NFE2L2 protein
CTD PMID:30698894 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions
increases expression
ISO bafilomycin A1 inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of NLRP3 protein]
bafilomycin A1 results in increased expression of NLRP3 protein
CTD PMID:32645460 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 decreases expression ISO bafilomycin A1 results in decreased expression of NR5A1 protein CTD PMID:29524503 NCBI chr 3:22,998,900...23,020,441
Ensembl chr 3:22,999,616...23,020,441
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
increases expression
ISO bafilomycin A1 promotes the reaction [Atorvastatin results in increased cleavage of PARP1 protein]; bafilomycin A1 promotes the reaction [brazilin results in increased expression of PARP1 protein modified form]; bafilomycin A1 promotes the reaction [Flavanones results in increased cleavage of PARP1 protein]; bafilomycin A1 promotes the reaction [fosbretabulin results in increased cleavage of PARP1 protein]; BNIP3 mutant form promotes the reaction [bafilomycin A1 results in increased cleavage of PARP1 protein]; HIF1A mutant form promotes the reaction [bafilomycin A1 results in increased cleavage of PARP1 protein]
bafilomycin A1 inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]
bafilomycin A1 results in increased expression of PARP1 protein modified form
CTD PMID:20876807, PMID:21616090, PMID:24321340, PMID:25981168, PMID:28063998, PMID:29111403, PMID:31310755 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO bafilomycin A1 affects the localization of and results in increased activity of RELA protein CTD PMID:10339586 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation
multiple interactions
ISO
EXP
bafilomycin A1 results in decreased phosphorylation of RPS6KB1 protein
bafilomycin A1 inhibits the reaction [EGF protein results in increased activity of and results in increased phosphorylation of RPS6KB1 protein]; bafilomycin A1 inhibits the reaction [INS protein results in increased phosphorylation of RPS6KB1 protein]
CTD PMID:22689575, PMID:31310755 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions ISO bafilomycin A1 inhibits the reaction [[Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] results in increased expression of RUNX2 mRNA] CTD PMID:23111315 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP bafilomycin A1 inhibits the reaction [resveratrol inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT1 protein]] CTD PMID:24889822 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Slc17a7 solute carrier family 17 member 7 multiple interactions EXP bafilomycin A1 inhibits the reaction [SLC17A7 protein results in increased uptake of Excitatory Amino Acid Agents]; bafilomycin A1 inhibits the reaction [SLC17A7 protein results in increased uptake of Zinc]; bafilomycin A1 inhibits the reaction [SLC30A3 protein promotes the reaction [SLC17A7 protein results in increased uptake of Zinc]] CTD PMID:15860731 NCBI chr 1:101,161,265...101,172,292
Ensembl chr 1:101,161,252...101,173,174
JBrowse link
G Slc30a3 solute carrier family 30 member 3 multiple interactions EXP bafilomycin A1 inhibits the reaction [SLC30A3 protein promotes the reaction [SLC17A7 protein results in increased uptake of Zinc]] CTD PMID:15860731 NCBI chr 6:26,629,752...26,650,106
Ensembl chr 6:26,642,783...26,650,105
JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions
increases expression
ISO bafilomycin A1 promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI1 protein]
bafilomycin A1 results in increased expression of SNAI1 protein
CTD PMID:32645460 NCBI chr 3:164,274,710...164,279,199
Ensembl chr 3:164,274,710...164,279,378
JBrowse link
G Snca synuclein alpha multiple interactions
increases expression
ISO [bafilomycin A1 co-treated with Rotenone] results in increased expression of SNCA protein
bafilomycin A1 results in increased expression of SNCA protein
CTD PMID:26031332 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Sort1 sortilin 1 decreases expression ISO bafilomycin A1 results in decreased expression of SORT1 protein CTD PMID:25805502 NCBI chr 2:211,078,092...211,156,312
Ensembl chr 2:211,078,334...211,156,312
JBrowse link
G Sqstm1 sequestosome 1 increases expression
multiple interactions
ISO
EXP
bafilomycin A1 results in increased expression of SQSTM1 protein
bafilomycin A1 promotes the reaction [Hydrogen Peroxide results in increased expression of SQSTM1 protein]
[Resveratrol co-treated with bafilomycin A1] results in increased expression of SQSTM1 protein; [Silicon Dioxide co-treated with bafilomycin A1] results in increased expression of SQSTM1 protein; [Silicon Dioxide co-treated with Vitamin D co-treated with bafilomycin A1] results in increased expression of SQSTM1 protein; [TNF protein co-treated with bafilomycin A1] results in increased expression of SQSTM1 protein; [Vitamin D co-treated with bafilomycin A1] results in increased expression of SQSTM1 protein; bafilomycin A1 inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of SQSTM1 protein]; bafilomycin A1 inhibits the reaction [dactolisib results in decreased expression of SQSTM1 protein]; bafilomycin A1 inhibits the reaction [Resveratrol results in increased degradation of SQSTM1 protein]; bafilomycin A1 inhibits the reaction [Sorafenib results in decreased expression of SQSTM1 protein]; bafilomycin A1 promotes the reaction [N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SQSTM1 protein]; Fingolimod Hydrochloride affects the reaction [bafilomycin A1 results in increased expression of SQSTM1 protein]; sodium arsenite promotes the reaction [bafilomycin A1 results in increased expression of SQSTM1 protein]
[bafilomycin A1 co-treated with Rotenone] results in increased expression of SQSTM1 protein; bafilomycin A1 inhibits the reaction [Resveratrol inhibits the reaction [Streptozocin results in increased expression of SQSTM1 protein]]; bafilomycin A1 inhibits the reaction [Sirolimus results in decreased expression of SQSTM1 protein]; Streptozocin promotes the reaction [bafilomycin A1 results in increased expression of SQSTM1 protein]
CTD PMID:21778691, PMID:21858812, PMID:23151917, PMID:24145604, PMID:24238063, PMID:24889822, PMID:25939952, PMID:25943029, PMID:26031332, PMID:28125038, PMID:29248574, PMID:29524503, PMID:30698894, PMID:32186374, PMID:32645460 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Tbk1 TANK-binding kinase 1 multiple interactions ISO bafilomycin A1 promotes the reaction [Lipopolysaccharides results in increased phosphorylation of TBK1 protein]; bafilomycin A1 promotes the reaction [Poly I-C results in increased phosphorylation of TBK1 protein] CTD PMID:25780039 NCBI chr 7:63,655,247...63,687,978
Ensembl chr 7:63,655,247...63,687,978
JBrowse link
G Tlr8 toll-like receptor 8 multiple interactions ISO bafilomycin A1 inhibits the reaction [resiquimod results in increased activity of TLR8 protein] CTD PMID:21398612 NCBI chr  X:28,539,158...28,562,803
Ensembl chr  X:28,539,158...28,562,803
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
ISO bafilomycin A1 results in increased expression of TNF mRNA
[TNF protein co-treated with bafilomycin A1] results in increased expression of MAP1LC3B protein alternative form; [TNF protein co-treated with bafilomycin A1] results in increased expression of SQSTM1 protein; resveratrol promotes the reaction [[TNF protein co-treated with bafilomycin A1] results in increased expression of MAP1LC3B protein alternative form]
CTD PMID:16932910, PMID:24145604 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tomm20 translocase of outer mitochondrial membrane 20 increases expression
multiple interactions
ISO bafilomycin A1 results in increased expression of TOMM20 protein
Triiodothyronine promotes the reaction [bafilomycin A1 results in increased expression of TOMM20 protein]
CTD PMID:30209975 NCBI chr19:59,863,421...59,873,411
Ensembl chr19:59,863,421...59,873,411
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [bafilomycin A1 co-treated with cobaltous chloride co-treated with TP53 gene mutant form] results in increased activity of CASP3 protein; bafilomycin A1 inhibits the reaction [[cobaltous chloride co-treated with TP53 gene mutant form] results in increased activity of CTSB protein] CTD PMID:23380477 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 multiple interactions EXP bafilomycin A1 affects the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide affects the reaction [Glucose affects the phosphorylation of ULK1 protein]] CTD PMID:29128638 NCBI chr12:51,908,105...51,934,704
Ensembl chr12:51,908,448...51,934,702
JBrowse link
G Vdac1 voltage-dependent anion channel 1 multiple interactions
increases expression
ISO Triiodothyronine promotes the reaction [bafilomycin A1 results in increased expression of VDAC1 protein] CTD PMID:30209975 NCBI chr10:37,724,915...37,752,827
Ensembl chr10:37,724,915...37,752,826
JBrowse link
G Vdr vitamin D receptor multiple interactions ISO [bafilomycin A1 co-treated with Vitamin D] results in increased expression of VDR protein; [Silicon Dioxide co-treated with Vitamin D co-treated with bafilomycin A1] results in increased expression of VDR protein CTD PMID:30698894 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166
JBrowse link
G Vim vimentin multiple interactions
increases expression
ISO bafilomycin A1 promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of VIM protein]
bafilomycin A1 results in increased expression of VIM protein
CTD PMID:32645460 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
beta-Zearalanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afp alpha-fetoprotein affects binding EXP taleranol binds to AFP protein CTD PMID:23013281, PMID:25349334 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
JBrowse link
G Ar androgen receptor affects binding
decreases activity
EXP
ISO
taleranol binds to AR protein
taleranol results in decreased activity of AR protein
CTD PMID:14565775, PMID:25455890 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Esr1 estrogen receptor 1 increases activity ISO taleranol results in increased activity of ESR1 protein CTD PMID:11331656, PMID:25455890 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Shbg sex hormone binding globulin affects binding ISO taleranol binds to SHBG protein CTD PMID:25349334 NCBI chr10:56,219,861...56,237,354
Ensembl chr10:56,219,858...56,223,245
JBrowse link
borrelidin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator decreases response to substance ISO BCL2 protein results in decreased susceptibility to borrelidin CTD PMID:24155182 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage
ISO borrelidin results in increased activity of CASP3 protein
borrelidin results in increased cleavage of CASP3 protein
CTD PMID:14563161, PMID:26271225 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases activity ISO borrelidin results in increased activity of CASP8 protein CTD PMID:14563161 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO borrelidin results in increased expression of DDIT3 protein CTD PMID:21678129 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases phosphorylation ISO borrelidin results in increased phosphorylation of EIF2A protein CTD PMID:26271225 NCBI chr 2:148,722,343...148,755,781
Ensembl chr 2:148,722,231...148,755,520
JBrowse link
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 increases activity ISO borrelidin results in increased activity of EIF2AK4 protein CTD PMID:21678129 NCBI chr 3:110,159,624...110,245,382
Ensembl chr 3:110,159,708...110,249,217
JBrowse link
G Tars1 threonyl-tRNA synthetase 1 decreases activity
multiple interactions
ISO borrelidin results in decreased activity of TARS1 protein
borrelidin analog binds to and affects the folding of TARS1 protein; borrelidin binds to and affects the folding of TARS1 protein; borrelidin binds to and results in decreased activity of TARS1 protein
CTD PMID:25489076, PMID:25824639, PMID:26271225 NCBI chr 2:61,394,632...61,414,115
Ensembl chr 2:61,394,770...61,414,102
JBrowse link
G Vegfa vascular endothelial growth factor A affects splicing
multiple interactions
ISO borrelidin affects the splicing of VEGFA mRNA; borrelidin analog affects the splicing of VEGFA mRNA
borrelidin analog inhibits the reaction [WBP4 protein affects the splicing of VEGFA mRNA]
CTD PMID:22822423 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Wbp4 WW domain binding protein 4 affects binding
multiple interactions
ISO borrelidin analog binds to WBP4 protein; borrelidin binds to WBP4 protein
borrelidin analog inhibits the reaction [WBP4 protein affects the splicing of VEGFA mRNA]
CTD PMID:22822423 NCBI chr15:61,745,989...61,772,516
Ensembl chr15:61,745,989...61,772,516
JBrowse link
brefeldin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen multiple interactions EXP Brefeldin A inhibits the reaction [AGT protein results in increased phosphorylation of AKT1 protein] CTD PMID:15525798 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
EXP Brefeldin A inhibits the reaction [AGT protein results in increased phosphorylation of AKT1 protein]
Brefeldin A results in decreased phosphorylation of AKT1 protein
CTD PMID:15525798, PMID:24090963 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO Brefeldin A results in increased expression of ATF4 protein CTD PMID:24865413, PMID:27358234 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atf6 activating transcription factor 6 multiple interactions ISO Apigenin inhibits the reaction [Brefeldin A results in increased cleavage of ATF6 protein] CTD PMID:20493918 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
JBrowse link
G Atp7a ATPase copper transporting alpha multiple interactions ISO Brefeldin A inhibits the reaction [ATP7A protein affects the localization of Doxorubicin] CTD PMID:17510416 NCBI chr  X:77,076,085...77,193,644
Ensembl chr  X:77,076,106...77,193,644
JBrowse link
G Atp7b ATPase copper transporting beta multiple interactions ISO Brefeldin A inhibits the reaction [Copper affects the localization of ATP7B protein] CTD PMID:10982773 NCBI chr16:74,865,516...74,944,935
Ensembl chr16:74,865,516...74,945,286
JBrowse link
G Casp12 caspase 12 increases activity
multiple interactions
ISO Brefeldin A results in increased activity of CASP12 protein
Apigenin inhibits the reaction [Brefeldin A results in increased activity of CASP12 protein]
CTD PMID:20493918 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
JBrowse link
G Casp2 caspase 2 multiple interactions ISO Bortezomib promotes the reaction [Brefeldin A results in increased cleavage of and results in increased activity of CASP2 protein]; Brefeldin A promotes the reaction [Bortezomib results in increased cleavage of and results in increased activity of CASP2 protein]; Brefeldin A results in increased cleavage of and results in increased activity of CASP2 protein CTD PMID:18723477 NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO Brefeldin A results in increased activity of CASP3 protein
Apigenin inhibits the reaction [Brefeldin A results in increased activity of CASP3 protein]
CTD PMID:20150630, PMID:20493918 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cftr CF transmembrane conductance regulator decreases activity
multiple interactions
ISO Brefeldin A results in decreased activity of CFTR protein
Brefeldin A inhibits the reaction [5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; Brefeldin A inhibits the reaction [5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium results in increased activity of CFTR protein mutant form]; Brefeldin A inhibits the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; Brefeldin A inhibits the reaction [miglustat results in increased activity of CFTR protein mutant form]
CTD PMID:15371258, PMID:18230692 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Brefeldin A inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Brefeldin A inhibits the reaction [Quercetin results in increased secretion of CSF2 protein] CTD PMID:18346843 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO Brefeldin A inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA] CTD PMID:22167199 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions
ISO Brefeldin A results in increased expression of DDIT3 mRNA; Brefeldin A results in increased expression of DDIT3 protein
Acetylcysteine inhibits the reaction [Brefeldin A results in increased expression of DDIT3 protein]; Apigenin inhibits the reaction [Brefeldin A results in increased expression of DDIT3 protein]; Glutathione inhibits the reaction [Brefeldin A results in increased expression of DDIT3 protein]
CTD PMID:19428936, PMID:20493918, PMID:20626587, PMID:24865413, PMID:27358234 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases expression ISO Brefeldin A results in increased expression of EIF2AK3 protein CTD PMID:24865413 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions
increases phosphorylation
ISO Apigenin inhibits the reaction [Brefeldin A results in increased phosphorylation of ERN1 protein] CTD PMID:20493918 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Fhl1 four and a half LIM domains 1 multiple interactions EXP Brefeldin A inhibits the reaction [25-hydroxycholesterol results in increased expression of FHL1 mRNA] CTD PMID:17161435 NCBI chr  X:159,112,516...159,172,528
Ensembl chr  X:159,112,880...159,172,524
JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 multiple interactions
increases expression
ISO Apigenin inhibits the reaction [Brefeldin A results in increased expression of HSP90B1 protein] CTD PMID:20493918 NCBI chr 7:27,226,570...27,240,533
Ensembl chr 7:27,226,569...27,240,533
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [Brefeldin A results in increased expression of HSPA5 protein]; Apigenin inhibits the reaction [Brefeldin A results in increased expression of HSPA5 protein]; Glutathione inhibits the reaction [Brefeldin A results in increased expression of HSPA5 protein]
Brefeldin A results in increased expression of HSPA5 mRNA; Brefeldin A results in increased expression of HSPA5 protein
bortezomib inhibits the reaction [Brefeldin A results in increased expression of HSPA5 protein]
CTD PMID:12147617, PMID:18723477, PMID:19428936, PMID:20493918, PMID:20626587, PMID:27358234 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Il6 interleukin 6 decreases secretion
multiple interactions
ISO Brefeldin A results in decreased secretion of IL6 protein
Brefeldin A inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
CTD PMID:11216681, PMID:22102721, PMID:24849676 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
multiple interactions
EXP Brefeldin A results in decreased phosphorylation of MAPK1 protein
Brefeldin A inhibits the reaction [Levodopa results in increased phosphorylation of MAPK1 protein]
CTD PMID:24090963, PMID:25044243 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions
EXP Brefeldin A results in decreased phosphorylation of MAPK3 protein
Brefeldin A inhibits the reaction [Levodopa results in increased phosphorylation of MAPK3 protein]
CTD PMID:24090963, PMID:25044243 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nfe2l1 nuclear factor, erythroid 2-like 1 multiple interactions ISO Brefeldin A affects the reaction [sodium arsenite affects the localization of NFE2L1 protein] CTD PMID:20805060 NCBI chr10:84,686,762...84,699,313
Ensembl chr10:84,682,460...84,698,886
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO Brefeldin A inhibits the reaction [sodium arsenite results in increased activity of NFE2L2 protein] CTD PMID:20805060 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 decreases expression ISO Brefeldin A results in decreased expression of NR1I2 mRNA CTD PMID:25616597 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO Apigenin inhibits the reaction [Brefeldin A results in increased cleavage of PARP1 protein] CTD PMID:20493918 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Scnn1b sodium channel epithelial 1 subunit beta multiple interactions EXP Brefeldin A inhibits the reaction [Terbutaline inhibits the reaction [Oxygen deficiency results in decreased expression of SCNN1B protein]] CTD PMID:12608646 NCBI chr 1:191,829,547...191,883,991
Ensembl chr 1:191,829,555...191,884,298
JBrowse link
G Scnn1g sodium channel epithelial 1 subunit gamma multiple interactions EXP Brefeldin A inhibits the reaction [Terbutaline inhibits the reaction [Oxygen deficiency results in decreased expression of SCNN1G protein]] CTD PMID:12608646 NCBI chr 1:191,704,397...191,738,271
Ensembl chr 1:191,704,311...191,738,268
JBrowse link
G Tnf tumor necrosis factor decreases secretion ISO Brefeldin A results in decreased secretion of TNF protein CTD PMID:22102721 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b multiple interactions ISO Brefeldin A inhibits the reaction [Bortezomib results in increased localization of TNFRSF10A protein] CTD PMID:17326159 NCBI chr15:51,433,853...51,464,215 JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO Brefeldin A affects the reaction [Bortezomib results in increased susceptibility to and results in increased activity of TNFSF10 protein] CTD PMID:17326159 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 increases expression ISO Brefeldin A results in increased expression of TP53BP1 protein CTD PMID:27358234 NCBI chr 3:113,160,030...113,259,701
Ensembl chr 3:113,160,000...113,231,790
JBrowse link
G Vegfa vascular endothelial growth factor A decreases secretion
multiple interactions
increases expression
ISO Brefeldin A results in decreased secretion of VEGFA protein
Brefeldin A inhibits the reaction [cobaltous chloride results in increased secretion of VEGFA protein]
Brefeldin A results in increased expression of VEGFA mRNA
CTD PMID:12147617, PMID:20850416 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions
increases expression
increases activity
ISO bortezomib inhibits the reaction [Brefeldin A results in increased activity of XBP1 protein]
Brefeldin A results in increased expression of XBP1 protein
CTD PMID:18723477, PMID:27358234 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
bryostatin 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc3 baculoviral IAP repeat-containing 3 increases expression ISO bryostatin 1 results in increased expression of BIRC3 mRNA CTD PMID:14527959 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Cd22 CD22 molecule increases expression ISO bryostatin 1 results in increased expression of CD22 protein CTD PMID:10741703 NCBI chr 1:89,313,475...89,329,902
Ensembl chr 1:89,314,558...89,329,418
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO bryostatin 1 inhibits the reaction [Paclitaxel results in increased activity of CDK1 protein] CTD PMID:10516758 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO bryostatin 1 results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Il10 interleukin 10 decreases expression ISO bryostatin 1 analog results in decreased expression of IL10 mRNA; bryostatin 1 results in decreased expression of IL10 mRNA CTD PMID:15614042 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il12b interleukin 12B decreases expression
increases expression
ISO bryostatin 1 analog results in decreased expression of IL12B mRNA
bryostatin 1 results in increased expression of IL12B mRNA
CTD PMID:15614042 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Itgax integrin subunit alpha X increases expression ISO bryostatin 1 results in increased expression of ITGAX protein CTD PMID:10741703 NCBI chr 1:199,555,560...199,576,948
Ensembl chr 1:199,555,722...199,576,932
JBrowse link
G Prkca protein kinase C, alpha multiple interactions
decreases expression
ISO [bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCA protein
bryostatin 1 results in decreased expression of PRKCA protein
CTD PMID:8892972 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Prkcb protein kinase C, beta multiple interactions
decreases expression
ISO [bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCB protein; [bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCB protein alternative form
bryostatin 1 results in decreased expression of PRKCB protein; bryostatin 1 results in decreased expression of PRKCB protein alternative form
CTD PMID:8892972 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831
JBrowse link
G Prkcg protein kinase C, gamma multiple interactions
decreases expression
ISO [bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCG protein
bryostatin 1 results in decreased expression of PRKCG protein
CTD PMID:8892972 NCBI chr 1:64,407,098...64,433,698
Ensembl chr 1:64,407,114...64,433,636
JBrowse link
bryostatin 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F3 coagulation factor III, tissue factor increases expression ISO bryostatin 2 results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
clarithromycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
ISO Clarithromycin inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Clarithromycin results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 increases expression ISO Clarithromycin results in increased expression of ASAH1 mRNA CTD PMID:15342952 NCBI chr16:53,998,604...54,030,006
Ensembl chr16:53,998,560...54,040,836
JBrowse link
G Ckm creatine kinase, M-type multiple interactions ISO [Clarithromycin co-treated with Simvastatin] results in increased expression of CKM protein CTD PMID:19252767 NCBI chr 1:80,321,507...80,331,841
Ensembl chr 1:80,321,585...80,331,841
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [Ofloxacin co-treated with Clarithromycin] inhibits the reaction [CYP1A2 protein results in increased metabolism of Theophylline] CTD PMID:11408986 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Clarithromycin results in increased expression of FOS mRNA; Clarithromycin results in increased expression of FOS protein CTD PMID:32454074 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Ifng interferon gamma multiple interactions EXP
ISO
[IFNG protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Clarithromycin CTD PMID:19362101 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO
EXP
[IFNG protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Clarithromycin; [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Clarithromycin CTD PMID:19362101 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il4 interleukin 4 decreases expression ISO Clarithromycin results in decreased expression of IL4 protein CTD PMID:16006447 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
ISO
EXP
[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Clarithromycin
Clarithromycin results in decreased expression of IL6 mRNA
CTD PMID:9869567, PMID:19362101 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Clarithromycin results in increased expression of INHBE mRNA CTD PMID:15342952 NCBI chr 7:70,641,423...70,642,848
Ensembl chr 7:70,640,075...70,643,169
JBrowse link
G Itgb4 integrin subunit beta 4 decreases expression ISO Clarithromycin results in decreased expression of ITGB4 protein CTD PMID:14687228 NCBI chr10:104,524,000...104,560,180
Ensembl chr10:104,523,996...104,561,078
JBrowse link
G Kcne2 potassium voltage-gated channel subfamily E regulatory subunit 2 multiple interactions ISO [KCNE2 protein mutant form binds to KCNH2 protein] which results in increased susceptibility to Clarithromycin CTD PMID:10219239 NCBI chr11:32,434,786...32,447,264
Ensembl chr11:32,440,237...32,447,259
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity
ISO [KCNE2 protein mutant form binds to KCNH2 protein] which results in increased susceptibility to Clarithromycin
Clarithromycin results in decreased activity of KCNH2 protein
CTD PMID:10219239, PMID:24052561 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Lss lanosterol synthase decreases expression ISO Clarithromycin results in decreased expression of LSS mRNA CTD PMID:15342952 NCBI chr20:12,844,522...12,870,474
Ensembl chr20:12,842,884...12,870,497
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression EXP Clarithromycin results in decreased expression of MMP9 mRNA CTD PMID:9869567 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II decreases expression ISO Clarithromycin results in decreased expression of COX2 protein CTD PMID:31915244 NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689
JBrowse link
G Mtif2 mitochondrial translational initiation factor 2 decreases response to substance ISO MTIF2 protein results in decreased susceptibility to Clarithromycin CTD PMID:31915244 NCBI chr14:113,946,084...113,965,574
Ensembl chr14:113,945,843...113,965,745
JBrowse link
G Phyh phytanoyl-CoA 2-hydroxylase decreases expression ISO Clarithromycin results in decreased expression of PHYH mRNA CTD PMID:15342952 NCBI chr17:77,287,580...77,304,482
Ensembl chr17:77,287,188...77,304,530
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO Clarithromycin inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein] CTD PMID:21430235 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO
EXP
[IFNG protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Clarithromycin; [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Clarithromycin
Clarithromycin results in decreased expression of TNF mRNA
CTD PMID:9869567, PMID:19362101 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
concanamycin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO concanamycin A inhibits the reaction [enterotoxin C, staphylococcal results in increased expression of BAX protein] CTD PMID:27742270 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression
multiple interactions
ISO concanamycin A results in increased expression of BNIP3 mRNA
lapatinib inhibits the reaction [concanamycin A results in increased expression of BNIP3 mRNA]
CTD PMID:25981168 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G Casp3 caspase 3 multiple interactions ISO concanamycin A inhibits the reaction [enterotoxin C, staphylococcal analog results in increased activity of CASP3 protein]; concanamycin A inhibits the reaction [enterotoxin C, staphylococcal results in increased activity of CASP3 protein] CTD PMID:27742270 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 multiple interactions ISO concanamycin A inhibits the reaction [enterotoxin C, staphylococcal analog results in increased activity of CASP9 protein]; concanamycin A inhibits the reaction [enterotoxin C, staphylococcal results in increased activity of CASP9 protein] CTD PMID:27742270 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO concanamycin A results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression
multiple interactions
ISO concanamycin A results in increased expression of HIF1A protein
lapatinib inhibits the reaction [concanamycin A results in increased expression of HIF1A protein]
CTD PMID:25981168 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [lapatinib co-treated with concanamycin A] results in increased cleavage of PARP1 protein CTD PMID:25981168 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
Doramectin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression
decreases activity
ISO doramectin results in decreased expression of ABCB1 mRNA; doramectin results in decreased expression of ABCB1 protein
doramectin results in decreased activity of ABCB1A protein
doramectin results in decreased expression of ABCB1A protein
CTD PMID:17134887, PMID:19879343, PMID:20487225 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Actb actin, beta decreases expression ISO doramectin results in decreased expression of ACTB protein CTD PMID:19879343 NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO doramectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO doramectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]; doramectin inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; doramectin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666, PMID:27773686 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Tubb3 tubulin, beta 3 class III decreases expression ISO doramectin results in decreased expression of TUBB3 protein CTD PMID:19879343 NCBI chr19:56,220,759...56,229,813
Ensembl chr19:56,220,755...56,229,813
JBrowse link
emamectin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity
multiple interactions
ISO emamectin results in decreased activity of ABCB1 protein
emamectin inhibits the reaction [ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]
emamectin results in decreased activity of ABCB1A protein
emamectin inhibits the reaction [ABCB1A protein results in increased transport of bisbenzimide ethoxide trihydrochloride]
CTD PMID:25865432 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions
decreases activity
ISO emamectin inhibits the reaction [ABCC1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]
emamectin results in decreased activity of ABCC1 protein
CTD PMID:25865432 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO emamectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO emamectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]; emamectin inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; emamectin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666, PMID:27773686 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
emamectin benzoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase multiple interactions
decreases activity
ISO Plant Oils inhibits the reaction [emamectin benzoate results in decreased activity of CAT protein] CTD PMID:29268245 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases expression
ISO Plant Oils inhibits the reaction [emamectin benzoate results in increased expression of CYP2E1 mRNA] CTD PMID:29268245 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Dio1 iodothyronine deiodinase 1 decreases activity ISO emamectin benzoate results in decreased activity of DIO1 protein CTD PMID:29228274 NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 increases expression
multiple interactions
ISO emamectin benzoate results in increased expression of MGST1 mRNA
Plant Oils inhibits the reaction [emamectin benzoate results in increased expression of MGST1 mRNA]
CTD PMID:29268245 NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607
JBrowse link
G Nts neurotensin affects activity ISO emamectin benzoate affects the activity of NTS protein CTD PMID:23611293 NCBI chr 7:44,111,594...44,120,998
Ensembl chr 7:44,111,151...44,121,130
JBrowse link
epothilone A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases expression
multiple interactions
ISO epothilone A results in increased expression of CASP3 mRNA
[epothilone A co-treated with Metformin] results in increased expression of CASP3 mRNA; Sodium Salicylate promotes the reaction [[epothilone A co-treated with Metformin] results in increased expression of CASP3 mRNA]; triciribine promotes the reaction [[epothilone A co-treated with Metformin] results in increased expression of CASP3 mRNA]
CTD PMID:29117515 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G H2ax H2A.X variant histone multiple interactions
increases expression
ISO [epothilone A co-treated with Metformin] results in increased expression of H2AX mRNA
epothilone A results in increased expression of H2AX mRNA
CTD PMID:29117515 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases expression
ISO [epothilone A co-treated with Metformin] results in increased expression of PARP1 mRNA; Sodium Salicylate inhibits the reaction [epothilone A results in increased expression of PARP1 mRNA]; triciribine inhibits the reaction [epothilone A results in increased expression of PARP1 mRNA]; triciribine promotes the reaction [[epothilone A co-treated with Metformin] results in increased expression of PARP1 mRNA] CTD PMID:29117515 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
epothilone B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calca calcitonin-related polypeptide alpha decreases expression
multiple interactions
EXP epothilone B results in decreased expression of CALCA protein
epothilone B affects the reaction [[Capsaicin co-treated with NGF protein] results in increased secretion of CALCA protein]; epothilone B inhibits the reaction [Potassium results in increased secretion of CALCA protein]; epothilone B promotes the reaction [[Potassium co-treated with NGF protein] results in increased secretion of CALCA protein]
CTD PMID:26883566 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Ngf nerve growth factor multiple interactions EXP epothilone B affects the reaction [[Capsaicin co-treated with NGF protein] results in increased secretion of CALCA protein]; epothilone B promotes the reaction [[Potassium co-treated with NGF protein] results in increased secretion of CALCA protein] CTD PMID:26883566 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
eprinomectin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity ISO eprinomectin results in decreased activity of ABCB1A protein CTD PMID:17134887 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO eprinomectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO eprinomectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
erythromycin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
ISO Erythromycin inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Erythromycin results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
affects transport
ISO
EXP
Erythromycin inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]; Erythromycin inhibits the reaction [ABCB1 protein results in increased transport of quinidinium]
ABCB1 protein affects the transport of Erythromycin
CTD PMID:12235267, PMID:15304119, PMID:25268938 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Acaca acetyl-CoA carboxylase alpha multiple interactions
increases expression
ISO [Penicillin G co-treated with Erythromycin] results in increased expression of ACACA mRNA
Erythromycin results in increased expression of ACACA mRNA
CTD PMID:27503388 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Acly ATP citrate lyase increases expression
multiple interactions
ISO Erythromycin results in increased expression of ACLY mRNA
[Penicillin G co-treated with Erythromycin] results in increased expression of ACLY mRNA
CTD PMID:27503388 NCBI chr10:88,392,248...88,442,845
Ensembl chr10:88,392,248...88,442,845
JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 increases expression ISO Erythromycin results in increased expression of ASAH1 mRNA CTD PMID:17175557 NCBI chr16:53,998,604...54,030,006
Ensembl chr16:53,998,560...54,040,836
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) decreases expression ISO Erythromycin results in decreased expression of ASNS mRNA CTD PMID:17175557 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO [Erythromycin co-treated with IL1B protein] results in increased activity of CASP3 protein; [Erythromycin co-treated with IL6 protein] results in increased activity of CASP3 protein; [Erythromycin co-treated with TNF protein] results in increased activity of CASP3 protein; [TNF protein co-treated with IL6 protein co-treated with IL1B protein] inhibits the reaction [Erythromycin results in increased activity of CASP3 protein] CTD PMID:30876886 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase multiple interactions ISO [Benzoyl Peroxide co-treated with Erythromycin] results in decreased activity of CAT protein CTD PMID:11809596 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
multiple interactions
ISO Erythromycin results in increased expression of CCL2 mRNA
[Penicillin G co-treated with Erythromycin] results in increased expression of CCL2 mRNA
CTD PMID:27503388 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 increases expression
multiple interactions
ISO Erythromycin results in increased expression of CCR2 mRNA
[Penicillin G co-treated with Erythromycin] results in increased expression of CCR2 mRNA
CTD PMID:27503388
G Cd34 CD34 molecule increases expression ISO Erythromycin results in increased expression of CD34 protein CTD PMID:16297520 NCBI chr13:113,691,842...113,711,259
Ensembl chr13:113,691,932...113,711,647
JBrowse link
G Cd36 CD36 molecule increases expression
multiple interactions
ISO Erythromycin results in increased expression of CD36 mRNA
[Penicillin G co-treated with Erythromycin] results in increased expression of CD36 mRNA
CTD PMID:27503388 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions
increases expression
ISO [Penicillin G co-treated with Erythromycin] results in increased expression of CPT1A mRNA
Erythromycin results in increased expression of CPT1A mRNA
CTD PMID:27503388 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Crp C-reactive protein increases expression
multiple interactions
ISO Erythromycin results in increased expression of CRP mRNA
[Penicillin G co-treated with Erythromycin] results in increased expression of CRP mRNA
CTD PMID:27503388 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Cs citrate synthase increases expression
multiple interactions
ISO Erythromycin results in increased expression of CS mRNA
[Penicillin G co-treated with Erythromycin] results in increased expression of CS mRNA
CTD PMID:27503388 NCBI chr 7:2,752,680...2,778,963
Ensembl chr 7:2,752,680...2,778,963
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression ISO Erythromycin results in increased expression of CXCR4 protein CTD PMID:19502290 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 increases expression ISO Erythromycin results in increased expression of CYP11B2 CTD PMID:17822730 NCBI chr 7:116,155,928...116,161,781
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Erythromycin results in decreased activity of CYP2C29 protein CTD PMID:18420780 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO Erythromycin results in decreased activity of CYP2D22 protein CTD PMID:18420780 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 decreases methylation ISO CYP3A5 protein results in decreased methylation of Erythromycin CTD PMID:15383492 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Defb1 defensin beta 1 decreases expression
multiple interactions
ISO Erythromycin results in decreased expression of DEFB1 mRNA
[Penicillin G co-treated with Erythromycin] results in decreased expression of DEFB1 mRNA
CTD PMID:27503388 NCBI chr16:75,294,385...75,309,127
Ensembl chr16:75,294,376...75,309,176
JBrowse link
G Depp1 DEPP1, autophagy regulator increases expression ISO Erythromycin results in increased expression of DEPP1 mRNA CTD PMID:17175557 NCBI chr 4:148,780,330...148,784,566
Ensembl chr 4:148,782,479...148,784,562
JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 multiple interactions ISO [Penicillin G co-treated with Erythromycin] results in increased expression of DGAT1 mRNA CTD PMID:27503388 NCBI chr 7:117,566,363...117,576,735
Ensembl chr 7:117,566,368...117,576,737
JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 multiple interactions ISO [Penicillin G co-treated with Erythromycin] results in increased expression of DGAT2 mRNA CTD PMID:27503388 NCBI chr 1:164,113,459...164,143,818
Ensembl chr 1:164,113,459...164,143,818
JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression
multiple interactions
ISO Erythromycin results in increased expression of FABP1 mRNA
[Penicillin G co-treated with Erythromycin] results in increased expression of FABP1 mRNA
CTD PMID:17175557, PMID:27503388 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954
JBrowse link
G Fasn fatty acid synthase increases expression
multiple interactions
ISO Erythromycin results in increased expression of FASN mRNA
[Penicillin G co-treated with Erythromycin] results in increased expression of FASN mRNA
CTD PMID:27503388 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Erythromycin results in increased expression of FOS mRNA; Erythromycin results in increased expression of FOS protein CTD PMID:32454074 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial increases expression
multiple interactions
ISO Erythromycin results in increased expression of GPAM mRNA
[Penicillin G co-treated with Erythromycin] results in increased expression of GPAM mRNA
CTD PMID:27503388 NCBI chr 1:275,843,823...275,906,880
Ensembl chr 1:275,846,819...275,906,686
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Erythromycin inhibits the reaction [Particulate Matter results in increased expression of HMOX1 mRNA]; Erythromycin inhibits the reaction [Vehicle Emissions results in increased expression of HMOX1 mRNA] CTD PMID:23291319 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hpn hepsin increases expression ISO Erythromycin results in increased expression of HPN mRNA CTD PMID:17175557 NCBI chr 1:89,534,112...89,549,575
Ensembl chr 1:89,534,106...89,543,967
JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions EXP [Diphenhydramine results in decreased activity of HRH1 protein] which results in decreased susceptibility to Erythromycin CTD PMID:12856827 NCBI chr 4:146,374,596...146,458,148
Ensembl chr 4:146,455,332...146,457,074
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO Erythromycin results in increased expression of ICAM1 protein CTD PMID:14729754, PMID:16297520 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifng interferon gamma multiple interactions
increases expression
ISO [Penicillin G co-treated with Erythromycin] results in increased expression of IFNG mRNA
Erythromycin results in increased expression of IFNG mRNA
CTD PMID:27503388 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il1a interleukin 1 alpha increases expression
multiple interactions
ISO Erythromycin results in increased expression of IL1A mRNA
[Penicillin G co-treated with Erythromycin] results in increased expression of IL1A mRNA
CTD PMID:27503388 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [Erythromycin co-treated with IL1B protein] results in increased activity of CASP3 protein; [TNF protein co-treated with IL6 protein co-treated with IL1B protein] inhibits the reaction [Erythromycin results in increased activity of CASP3 protein] CTD PMID:30876886 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
ISO Erythromycin results in increased expression of IL6 mRNA
[Erythromycin co-treated with IL6 protein] results in increased activity of CASP3 protein; [TNF protein co-treated with IL6 protein co-treated with IL1B protein] inhibits the reaction [Erythromycin results in increased activity of CASP3 protein]
[Penicillin G co-treated with Erythromycin] results in increased expression of IL6 mRNA
CTD PMID:27503388, PMID:30876886 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Erythromycin results in increased expression of INHBE mRNA CTD PMID:17175557 NCBI chr 7:70,641,423...70,642,848
Ensembl chr 7:70,640,075...70,643,169
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 affects binding
decreases activity
multiple interactions
ISO Erythromycin binds to KCNH2 protein
Erythromycin results in decreased activity of KCNH2 protein
Erythromycin affects the reaction [KCNH2 protein results in decreased susceptibility to Doxorubicin]; Erythromycin binds to and results in decreased activity of KCNH2 protein
CTD PMID:15272206, PMID:16086867, PMID:18701618, PMID:24052561 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Lbp lipopolysaccharide binding protein multiple interactions ISO [Penicillin G co-treated with Erythromycin] results in increased expression of LBP mRNA CTD PMID:27503388 NCBI chr 3:154,786,232...154,812,910
Ensembl chr 3:154,786,215...154,813,464
JBrowse link
G LOC100364500 RT1 class I, locus CE11-like affects expression ISO Erythromycin affects the expression of HLA-A mRNA CTD PMID:25811541 NCBI chr20:2,704,153...2,707,111
Ensembl chr20:2,704,148...2,707,120
JBrowse link
G Lss lanosterol synthase increases expression ISO Erythromycin results in increased expression of LSS mRNA CTD PMID:17175557 NCBI chr20:12,844,522...12,870,474
Ensembl chr20:12,842,884...12,870,497
JBrowse link
G Mttp microsomal triglyceride transfer protein multiple interactions ISO [Penicillin G co-treated with Erythromycin] results in increased expression of MTTP mRNA CTD PMID:27503388 NCBI chr 2:243,366,181...243,407,608
Ensembl chr 2:243,366,181...243,407,608
JBrowse link
G Muc2 mucin 2, oligomeric mucus/gel-forming decreases expression
multiple interactions
ISO Erythromycin results in decreased expression of MUC2 mRNA
[Penicillin G co-treated with Erythromycin] results in decreased expression of MUC2 mRNA
CTD PMID:27503388 NCBI chr 1:214,663,929...214,693,197 JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO Erythromycin inhibits the reaction [Particulate Matter results in increased activity of NFE2L2 protein]; Erythromycin inhibits the reaction [Vehicle Emissions results in increased activity of NFE2L2 protein] CTD PMID:23291319 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression
multiple interactions
ISO Erythromycin results in increased expression of NFKB1 mRNA
[Penicillin G co-treated with Erythromycin] results in increased expression of NFKB1 mRNA
CTD PMID:27503388 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO Erythromycin inhibits the reaction [Particulate Matter results in increased expression of NQO1 mRNA]; Erythromycin inhibits the reaction [Vehicle Emissions results in increased expression of NQO1 mRNA] CTD PMID:23291319 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression
decreases expression
ISO Erythromycin results in increased expression of NUPR1 mRNA
Erythromycin results in decreased expression of NUPR1 mRNA
CTD PMID:17175557 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524
JBrowse link
G Pla2g2a phospholipase A2 group IIA decreases expression ISO Erythromycin results in decreased expression of PLA2G2A mRNA CTD PMID:27503388 NCBI chr 5:157,282,650...157,285,295
Ensembl chr 5:157,282,669...157,285,328
JBrowse link
G Reg3g regenerating family member 3 gamma multiple interactions
decreases expression
ISO [Penicillin G co-treated with Erythromycin] results in decreased expression of REG3G mRNA
Erythromycin results in decreased expression of REG3G mRNA
CTD PMID:27503388 NCBI chr 4:109,529,679...109,532,234
Ensembl chr 4:109,529,679...109,532,234
JBrowse link
G Retnlb resistin like beta multiple interactions
decreases expression
ISO [Penicillin G co-treated with Erythromycin] results in decreased expression of RETNLB mRNA
Erythromycin results in decreased expression of RETNLB mRNA
CTD PMID:27503388 NCBI chr11:54,565,471...54,567,578
Ensembl chr11:54,565,472...54,567,357
JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions
increases expression
ISO [Penicillin G co-treated with Erythromycin] results in increased expression of SCD1 mRNA
Erythromycin results in increased expression of SCD1 mRNA
CTD PMID:27503388 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Sele selectin E increases expression ISO Erythromycin results in increased expression of SELE protein CTD PMID:16297520 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Sell selectin L increases expression ISO Erythromycin results in increased expression of SELL protein CTD PMID:16297520 NCBI chr13:82,369,820...82,387,774
Ensembl chr13:82,369,493...82,387,631
JBrowse link
G Slc22a7 solute carrier family 22 member 7 multiple interactions ISO Erythromycin inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]
Erythromycin inhibits the reaction [SLC22A7 protein results in increased uptake of Glutarates]
CTD PMID:12065749, PMID:15901346 NCBI chr 9:16,925,321...16,931,119
Ensembl chr 9:16,924,520...16,931,766
JBrowse link
G Slc27a2 solute carrier family 27 member 2 multiple interactions ISO [Penicillin G co-treated with Erythromycin] results in increased expression of SLC27A2 mRNA CTD PMID:27503388 NCBI chr 3:119,014,620...119,052,531
Ensembl chr 3:119,014,620...119,052,531
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression
multiple interactions
ISO Erythromycin results in increased expression of SREBF1 mRNA
[Penicillin G co-treated with Erythromycin] results in increased expression of SREBF1 mRNA
CTD PMID:27503388 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Tagln transgelin decreases expression ISO Erythromycin results in decreased expression of TAGLN mRNA CTD PMID:17567588 NCBI chr 8:50,222,895...50,228,369
Ensembl chr 8:50,222,896...50,231,357
JBrowse link
G Tlr4 toll-like receptor 4 increases expression
multiple interactions
ISO Erythromycin results in increased expression of TLR4 mRNA
[Penicillin G co-treated with Erythromycin] results in increased expression of TLR4 mRNA
CTD PMID:27503388 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
ISO Erythromycin results in increased expression of TNF mRNA
[Erythromycin co-treated with TNF protein] results in increased activity of CASP3 protein; [TNF protein co-treated with IL6 protein co-treated with IL1B protein] inhibits the reaction [Erythromycin results in increased activity of CASP3 protein]
[Penicillin G co-treated with Erythromycin] results in increased expression of TNF mRNA
CTD PMID:27503388, PMID:30876886 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression ISO Erythromycin results in increased expression of VCAM1 protein CTD PMID:16297520 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Erythromycin results in increased expression of WIPI1 mRNA CTD PMID:17175557 NCBI chr10:97,859,730...97,896,949
Ensembl chr10:97,859,727...97,896,525
JBrowse link
erythromycin estolate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression
decreases activity
EXP
ISO
Erythromycin Estolate results in decreased expression of ABCB11 mRNA
Erythromycin Estolate results in decreased activity of ABCB11 protein
CTD PMID:17522070, PMID:20829430, PMID:23956101, PMID:28437613 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases expression EXP Erythromycin Estolate results in increased expression of ABCB1 mRNA; Erythromycin Estolate results in increased expression of ABCB1A mRNA CTD PMID:17522070, PMID:24412560 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP Erythromycin Estolate results in increased expression of ABCC3 mRNA CTD PMID:17522070, PMID:24412560 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 increases expression EXP Erythromycin Estolate results in increased expression of ABCG5 mRNA CTD PMID:24412560 NCBI chr 6:7,935,771...7,961,207
Ensembl chr 6:7,935,771...7,961,207
JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 increases expression EXP Erythromycin Estolate results in increased expression of ABCG8 mRNA CTD PMID:24412560 NCBI chr 6:7,961,413...7,980,708
Ensembl chr 6:7,961,413...7,980,708
JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain decreases expression EXP Erythromycin Estolate results in decreased expression of ACADM mRNA CTD PMID:17522070 NCBI chr 2:260,124,418...260,148,589
Ensembl chr 2:260,124,418...260,148,589
JBrowse link
G Acly ATP citrate lyase decreases expression EXP Erythromycin Estolate results in decreased expression of ACLY mRNA CTD PMID:17522070 NCBI chr10:88,392,248...88,442,845
Ensembl chr10:88,392,248...88,442,845
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 decreases expression EXP Erythromycin Estolate results in decreased expression of ACSL1 mRNA CTD PMID:17522070 NCBI chr16:48,937,456...49,003,898
Ensembl chr16:48,937,456...49,003,246
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP Erythromycin Estolate results in increased expression of ALDH1A1 mRNA CTD PMID:24412560 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 decreases expression EXP Erythromycin Estolate results in decreased expression of ALDH3A2 mRNA CTD PMID:17522070 NCBI chr10:47,525,486...47,546,535
Ensembl chr10:47,525,493...47,546,345
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 decreases expression EXP Erythromycin Estolate results in decreased expression of APEX1 mRNA CTD PMID:17522070 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082
JBrowse link
G Aspm assembly factor for spindle microtubules decreases expression
increases expression
EXP Erythromycin Estolate results in decreased expression of ASPM mRNA
Erythromycin Estolate results in increased expression of ASPM mRNA
CTD PMID:24412560 NCBI chr13:56,546,021...56,591,793
Ensembl chr13:56,546,021...56,591,793
JBrowse link
G Aurkb aurora kinase B increases expression
decreases expression
EXP Erythromycin Estolate results in increased expression of AURKB mRNA
Erythromycin Estolate results in decreased expression of AURKB mRNA
CTD PMID:24412560 NCBI chr10:55,625,860...55,632,399
Ensembl chr10:55,626,741...55,634,991
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression EXP Erythromycin Estolate results in decreased expression of BAX mRNA CTD PMID:12883083 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression EXP Erythromycin Estolate results in increased expression of BCL2 mRNA CTD PMID:12883083 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression EXP Erythromycin Estolate results in increased expression of BTG2 mRNA CTD PMID:17522070 NCBI chr13:50,913,185...50,916,944
Ensembl chr13:50,913,180...50,916,982
JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I decreases expression EXP Erythromycin Estolate results in decreased expression of CACNA1I mRNA CTD PMID:24412560 NCBI chr 7:121,521,787...121,619,300
Ensembl chr 7:121,511,097...121,619,283
JBrowse link
G Calu calumenin increases expression EXP Erythromycin Estolate results in increased expression of CALU mRNA CTD PMID:17522070 NCBI chr 4:56,625,611...56,653,112
Ensembl chr 4:56,625,561...56,653,111
JBrowse link
G Car1 carbonic anhydrase 1 decreases expression EXP Erythromycin Estolate results in decreased expression of CAR1 mRNA CTD PMID:24412560 NCBI chr 2:88,185,204...88,227,486
Ensembl chr 2:88,217,188...88,227,479
JBrowse link
G Cat catalase decreases expression EXP Erythromycin Estolate results in decreased expression of CAT mRNA CTD PMID:17522070 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression EXP Erythromycin Estolate results in decreased expression of CCN2 mRNA CTD PMID:24412560 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Ccna2 cyclin A2 increases expression
decreases expression
EXP Erythromycin Estolate results in increased expression of CCNA2 mRNA
Erythromycin Estolate results in decreased expression of CCNA2 mRNA
CTD PMID:24412560 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 decreases expression
increases expression
EXP Erythromycin Estolate results in decreased expression of CCNB1 mRNA
Erythromycin Estolate results in increased expression of CCNB1 mRNA
CTD PMID:24412560 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Cdca3 cell division cycle associated 3 decreases expression
increases expression
EXP Erythromycin Estolate results in decreased expression of CDCA3 mRNA
Erythromycin Estolate results in increased expression of CDCA3 mRNA
CTD PMID:24412560 NCBI chr 4:157,347,876...157,351,889
Ensembl chr 4:157,348,020...157,351,604
JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression
decreases expression
EXP Erythromycin Estolate results in increased expression of CDK1 mRNA
Erythromycin Estolate results in decreased expression of CDK1 mRNA
CTD PMID:24412560 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 decreases expression EXP Erythromycin Estolate results in decreased expression of CEACAM1 mRNA CTD PMID:17522070 NCBI chr 1:82,327,955...82,344,345
Ensembl chr 1:82,327,955...82,344,345
JBrowse link
G Cenpw centromere protein W increases expression
decreases expression
EXP Erythromycin Estolate results in increased expression of CENPW mRNA
Erythromycin Estolate results in decreased expression of CENPW mRNA
CTD PMID:24412560 NCBI chr 1:29,915,443...29,920,598
Ensembl chr 1:29,915,443...29,920,598
JBrowse link
G Ces2h carboxylesterase 2H increases expression EXP Erythromycin Estolate results in increased expression of CES2 mRNA CTD PMID:24412560 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156
JBrowse link
G Chd2 chromodomain helicase DNA binding protein 2 increases expression EXP Erythromycin Estolate results in increased expression of CHD2 mRNA CTD PMID:24412560 NCBI chr 1:134,757,934...134,873,053
Ensembl chr 1:134,757,934...134,871,167
JBrowse link
G Ctsl cathepsin L increases expression EXP Erythromycin Estolate results in increased expression of CTSL mRNA CTD PMID:17522070 NCBI chr17:1,873,105...1,879,266
Ensembl chr17:1,872,848...1,879,279
JBrowse link
G Cyb5r3 cytochrome b5 reductase 3 decreases expression EXP Erythromycin Estolate results in decreased expression of CYB5R3 mRNA CTD PMID:17522070 NCBI chr 7:124,024,003...124,041,564
Ensembl chr 7:124,023,995...124,041,594
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression EXP Erythromycin Estolate results in increased expression of CYP1A1 mRNA CTD PMID:24412560 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp2d3 cytochrome P450, family 2, subfamily d, polypeptide 3 decreases expression EXP Erythromycin Estolate results in decreased expression of CYP2D3 mRNA CTD PMID:17522070 NCBI chr 7:123,634,400...123,638,757
Ensembl chr 7:123,625,590...123,638,765
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP Erythromycin Estolate results in increased expression of CYP3A23-3A1 mRNA CTD PMID:12883083 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases expression EXP Erythromycin Estolate results in increased expression of CYP3A9 mRNA CTD PMID:24412560 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 increases expression EXP Erythromycin Estolate results in increased expression of CYP8B1 mRNA CTD PMID:24412560 NCBI chr 8:130,548,418...130,550,388
Ensembl chr 8:130,548,418...130,550,388
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression EXP Erythromycin Estolate results in increased expression of DDIT3 mRNA CTD PMID:17522070 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dut deoxyuridine triphosphatase increases expression EXP Erythromycin Estolate results in increased expression of DUT mRNA CTD PMID:24412560 NCBI chr 3:117,514,399...117,525,450
Ensembl chr 3:117,514,444...117,525,446
JBrowse link
G Ect2 epithelial cell transforming 2 decreases expression
increases expression
EXP Erythromycin Estolate results in decreased expression of ECT2 mRNA
Erythromycin Estolate results in increased expression of ECT2 mRNA
CTD PMID:24412560 NCBI chr 2:112,769,385...112,831,476
Ensembl chr 2:112,769,385...112,831,476
JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression EXP Erythromycin Estolate results in increased expression of FABP1 mRNA CTD PMID:17522070 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954
JBrowse link
G Fads1 fatty acid desaturase 1 decreases expression EXP Erythromycin Estolate results in decreased expression of FADS1 mRNA CTD PMID:17522070 NCBI chr 1:226,234,034...226,249,118
Ensembl chr 1:226,234,074...226,249,138
JBrowse link
G Fam111a FAM111 trypsin like peptidase A increases expression
decreases expression
EXP Erythromycin Estolate results in increased expression of FAM111A mRNA
Erythromycin Estolate results in decreased expression of FAM111A mRNA
CTD PMID:24412560 NCBI chr 1:229,003,778...229,019,532
Ensembl chr 1:229,003,961...229,019,527
JBrowse link
G Fasn fatty acid synthase decreases expression EXP Erythromycin Estolate results in decreased expression of FASN mRNA CTD PMID:17522070 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fga fibrinogen alpha chain increases expression EXP Erythromycin Estolate results in increased expression of FGA mRNA CTD PMID:17522070 NCBI chr 2:181,997,562...182,013,726
Ensembl chr 2:182,006,242...182,013,763
JBrowse link
G Fgb fibrinogen beta chain increases expression EXP Erythromycin Estolate results in increased expression of FGB mRNA CTD PMID:17522070 NCBI chr 2:182,028,044...182,035,026
Ensembl chr 2:182,027,115...182,038,178
JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 decreases expression EXP Erythromycin Estolate results in decreased expression of FMO1 mRNA CTD PMID:17522070 NCBI chr13:80,712,885...80,745,095
Ensembl chr13:80,712,882...80,745,347
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression EXP Erythromycin Estolate results in decreased expression of G6PC mRNA CTD PMID:24412560 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression EXP Erythromycin Estolate results in increased expression of GADD45A mRNA CTD PMID:17522070 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gck glucokinase decreases expression EXP Erythromycin Estolate results in decreased expression of GCK mRNA CTD PMID:17522070 NCBI chr14:86,149,146...86,191,589
Ensembl chr14:86,148,928...86,190,659
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression EXP Erythromycin Estolate results in decreased expression of GPX1 mRNA CTD PMID:17522070 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gpx2 glutathione peroxidase 2 increases expression EXP Erythromycin Estolate results in increased expression of GPX2 mRNA CTD PMID:24412560 NCBI chr 6:99,839,960...99,843,245
Ensembl chr 6:99,839,960...99,843,245
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 decreases expression EXP Erythromycin Estolate results in decreased expression of GSTM3 mRNA CTD PMID:17522070 NCBI chr 2:210,685,338...210,688,133
Ensembl chr 2:210,685,197...210,688,272
JBrowse link
G Hibadh 3-hydroxyisobutyrate dehydrogenase decreases expression EXP Erythromycin Estolate results in decreased expression of HIBADH mRNA CTD PMID:17522070 NCBI chr 4:82,604,369...82,702,429
Ensembl chr 4:82,604,373...82,702,429
JBrowse link
G Hmmr hyaluronan-mediated motility receptor increases expression
decreases expression
EXP Erythromycin Estolate results in increased expression of HMMR mRNA
Erythromycin Estolate results in decreased expression of HMMR mRNA
CTD PMID:24412560 NCBI chr10:25,861,490...25,890,639
Ensembl chr10:25,861,490...25,890,639
JBrowse link
G Igf2r insulin-like growth factor 2 receptor increases expression EXP Erythromycin Estolate results in increased expression of IGF2R mRNA CTD PMID:24412560 NCBI chr 1:48,176,095...48,264,482
Ensembl chr 1:48,176,106...48,264,477
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression EXP Erythromycin Estolate results in increased expression of IGFBP1 mRNA CTD PMID:17522070 NCBI chr14:87,448,716...87,453,783
Ensembl chr14:87,448,692...87,453,785
JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 increases expression EXP Erythromycin Estolate results in increased expression of IGFBP2 mRNA CTD PMID:24412560 NCBI chr 9:80,118,029...80,144,804
Ensembl chr 9:80,118,029...80,144,789
JBrowse link
G Ip6k2 inositol hexakisphosphate kinase 2 decreases expression EXP Erythromycin Estolate results in decreased expression of IP6K2 mRNA CTD PMID:24412560 NCBI chr 8:117,574,136...117,599,849
Ensembl chr 8:117,574,161...117,599,848
JBrowse link
G Isy1 ISY1 splicing factor homolog increases expression EXP Erythromycin Estolate results in increased expression of ISY1 mRNA CTD PMID:24412560 NCBI chr 4:119,721,659...119,742,349
Ensembl chr 4:119,721,660...119,742,349
JBrowse link
G Kif20b kinesin family member 20B increases expression
decreases expression
EXP Erythromycin Estolate results in increased expression of KIF20B mRNA
Erythromycin Estolate results in decreased expression of KIF20B mRNA
CTD PMID:24412560 NCBI chr 1:253,220,038...253,275,523
Ensembl chr 1:253,221,812...253,275,490
JBrowse link
G Kif23 kinesin family member 23 increases expression
decreases expression
EXP Erythromycin Estolate results in increased expression of KIF23 mRNA
Erythromycin Estolate results in decreased expression of KIF23 mRNA
CTD PMID:24412560 NCBI chr 8:66,866,043...66,893,241
Ensembl chr 8:66,866,082...66,893,196
JBrowse link
G Kif2c kinesin family member 2C decreases expression
increases expression
EXP Erythromycin Estolate results in decreased expression of KIF2C mRNA
Erythromycin Estolate results in increased expression of KIF2C mRNA
CTD PMID:24412560 NCBI chr 5:136,027,923...136,053,268
Ensembl chr 5:136,027,934...136,053,210
JBrowse link
G Krt18 keratin 18 increases expression EXP Erythromycin Estolate results in increased expression of KRT18 mRNA CTD PMID:17522070 NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131
JBrowse link
G Lbp lipopolysaccharide binding protein increases expression EXP Erythromycin Estolate results in increased expression of LBP mRNA CTD PMID:17522070 NCBI chr 3:154,786,232...154,812,910
Ensembl chr 3:154,786,215...154,813,464
JBrowse link
G Lgals3 galectin 3 increases expression EXP Erythromycin Estolate results in increased expression of LGALS3 mRNA CTD PMID:17522070 NCBI chr15:24,153,602...24,165,537
Ensembl chr15:24,141,651...24,165,537
JBrowse link
G Lipc lipase C, hepatic type decreases expression EXP Erythromycin Estolate results in decreased expression of LIPC mRNA CTD PMID:17522070 NCBI chr 8:77,272,582...77,398,485
Ensembl chr 8:77,272,570...77,398,248
JBrowse link
G LOC100909485 spindlin-2-like decreases expression EXP Erythromycin Estolate results in decreased expression of SPIN2B mRNA CTD PMID:17522070 NCBI chr  X:18,340,413...18,342,492
Ensembl chr  X:18,340,688...18,341,467
JBrowse link
G Lpin1 lipin 1 decreases expression EXP Erythromycin Estolate results in decreased expression of LPIN1 mRNA CTD PMID:24412560 NCBI chr 6:41,796,214...41,905,149
Ensembl chr 6:41,799,749...41,870,046
JBrowse link
G Lpl lipoprotein lipase increases expression EXP Erythromycin Estolate results in increased expression of LPL mRNA CTD PMID:17522070 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Maob monoamine oxidase B decreases expression EXP Erythromycin Estolate results in decreased expression of MAOB mRNA CTD PMID:17522070 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534
JBrowse link
G Mir16 microRNA 16 increases expression EXP Erythromycin Estolate results in increased expression of MIR16 mRNA CTD PMID:17522070 NCBI chr 2:165,606,072...165,606,166
Ensembl chr 2:165,606,072...165,606,166
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression
decreases expression
EXP Erythromycin Estolate results in increased expression of MYC mRNA
Erythromycin Estolate results in decreased expression of MYC mRNA
CTD PMID:17522070, PMID:24412560 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Ncaph non-SMC condensin I complex, subunit H decreases expression
increases expression
EXP Erythromycin Estolate results in decreased expression of NCAPH mRNA
Erythromycin Estolate results in increased expression of NCAPH mRNA
CTD PMID:24412560 NCBI chr 3:119,583,798...119,611,148
Ensembl chr 3:119,583,648...119,611,136
JBrowse link
G Nfkbib NFKB inhibitor beta decreases expression EXP Erythromycin Estolate results in decreased expression of NFKBIB mRNA CTD PMID:17522070 NCBI chr 1:86,941,073...86,948,845
Ensembl chr 1:86,941,074...86,948,845
JBrowse link
G Noct nocturnin decreases expression EXP Erythromycin Estolate results in decreased expression of NOCT mRNA CTD PMID:24412560 NCBI chr 2:140,286,661...140,306,869
Ensembl chr 2:140,286,661...140,306,869
JBrowse link
G Nusap1 nucleolar and spindle associated protein 1 increases expression
decreases expression
EXP Erythromycin Estolate results in increased expression of NUSAP1 mRNA
Erythromycin Estolate results in decreased expression of NUSAP1 mRNA
CTD PMID:24412560 NCBI chr 3:111,422,267...111,452,600
Ensembl chr 3:111,422,267...111,452,971
JBrowse link
G Obp3 alpha-2u globulin PGCL4 decreases expression EXP Erythromycin Estolate results in decreased expression of OBP3 mRNA CTD PMID:24412560 NCBI chr 5:77,313,357...77,316,875 JBrowse link
G Otc ornithine transcarbamylase decreases expression EXP Erythromycin Estolate results in decreased expression of OTC mRNA CTD PMID:17522070 NCBI chr  X:13,524,804...13,601,074
Ensembl chr  X:13,524,607...13,601,069
JBrowse link
G Pclaf PCNA clamp associated factor increases expression
decreases expression
EXP Erythromycin Estolate results in increased expression of PCLAF mRNA
Erythromycin Estolate results in decreased expression of PCLAF mRNA
CTD PMID:24412560 NCBI chr 8:71,514,281...71,526,182
Ensembl chr 8:71,514,281...71,526,182
JBrowse link
G Pcmtd1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 decreases expression EXP Erythromycin Estolate results in decreased expression of PCMTD1 mRNA CTD PMID:24412560 NCBI chr 5:12,132,657...12,204,376
Ensembl chr 5:12,132,657...12,199,283
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 decreases expression EXP Erythromycin Estolate results in decreased expression of PDK4 mRNA CTD PMID:24412560 NCBI chr 4:30,546,772...30,556,774
Ensembl chr 4:30,546,664...30,556,814
JBrowse link
G Per1 period circadian regulator 1 decreases expression EXP Erythromycin Estolate results in decreased expression of PER1 mRNA CTD PMID:24412560 NCBI chr10:55,681,761...55,696,557
Ensembl chr10:55,687,050...55,695,994
JBrowse link
G Pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 decreases expression EXP Erythromycin Estolate results in decreased expression of PFKFB3 mRNA CTD PMID:24412560 NCBI chr17:70,632,778...70,713,736
Ensembl chr17:70,684,134...70,713,726
JBrowse link
G Pklr pyruvate kinase L/R decreases expression EXP Erythromycin Estolate results in decreased expression of PKLR mRNA CTD PMID:17522070 NCBI chr 2:188,449,158...188,458,034
Ensembl chr 2:188,449,210...188,459,592
JBrowse link
G Pygl glycogen phosphorylase L decreases expression EXP Erythromycin Estolate results in decreased expression of PYGL mRNA CTD PMID:17522070 NCBI chr 6:92,597,759...92,643,734
Ensembl chr 6:92,597,706...92,643,847
JBrowse link
G Rad51 RAD51 recombinase increases expression
decreases expression
EXP Erythromycin Estolate results in increased expression of RAD51 mRNA
Erythromycin Estolate results in decreased expression of RAD51 mRNA
CTD PMID:24412560 NCBI chr 3:110,918,240...110,942,920
Ensembl chr 3:110,918,243...110,942,917
JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 decreases expression
increases expression
EXP Erythromycin Estolate results in decreased expression of RRM2 mRNA
Erythromycin Estolate results in increased expression of RRM2 mRNA
CTD PMID:24412560 NCBI chr 6:43,884,627...43,890,818
Ensembl chr 6:43,884,678...43,889,515
JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression EXP Erythromycin Estolate results in increased expression of S100A8 mRNA CTD PMID:17522070 NCBI chr 2:190,073,239...190,074,333
Ensembl chr 2:190,073,815...190,074,354
JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression EXP Erythromycin Estolate results in increased expression of S100A9 mRNA CTD PMID:17522070 NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276
JBrowse link
G Serpina7 serpin family A member 7 increases expression EXP Erythromycin Estolate results in increased expression of SERPINA7 mRNA CTD PMID:24412560 NCBI chr  X:110,226,565...110,232,202
Ensembl chr  X:110,226,572...110,232,179
JBrowse link
G Sertad3 SERTA domain containing 3 increases expression EXP Erythromycin Estolate results in increased expression of SERTAD3 mRNA CTD PMID:24412560 NCBI chr 1:84,280,945...84,284,681
Ensembl chr 1:84,280,945...84,284,663
JBrowse link
G Shcbp1 SHC binding and spindle associated 1 decreases expression
increases expression
EXP Erythromycin Estolate results in decreased expression of SHCBP1 mRNA
Erythromycin Estolate results in increased expression of SHCBP1 mRNA
CTD PMID:24412560 NCBI chr16:90,613,826...90,642,683
Ensembl chr16:90,613,870...90,641,420
JBrowse link
G Slc38a2 solute carrier family 38, member 2 decreases expression EXP Erythromycin Estolate results in decreased expression of SLC38A2 mRNA CTD PMID:24412560 NCBI chr 7:138,088,654...138,100,869
Ensembl chr 7:138,088,649...138,100,841
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 increases expression EXP Erythromycin Estolate results in increased expression of SLCO1A4 mRNA CTD PMID:24412560 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 decreases expression EXP Erythromycin Estolate results in decreased expression of SLCO1B2 mRNA CTD PMID:17522070 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768
JBrowse link
G Spc25 SPC25 component of NDC80 kinetochore complex increases expression
decreases expression
EXP Erythromycin Estolate results in increased expression of SPC25 mRNA
Erythromycin Estolate results in decreased expression of SPC25 mRNA
CTD PMID:24412560 NCBI chr 3:55,438,534...55,451,961
Ensembl chr 3:55,438,536...55,451,798
JBrowse link
G Spink1 serine peptidase inhibitor, Kazal type 1 increases expression EXP Erythromycin Estolate results in increased expression of SPINK1 mRNA CTD PMID:24412560 NCBI chr18:38,221,919...38,242,092
Ensembl chr18:38,221,681...38,242,119
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression EXP Erythromycin Estolate results in decreased expression of SREBF1 mRNA CTD PMID:17522070 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression EXP Erythromycin Estolate results in increased expression of STAT3 mRNA CTD PMID:17522070 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Styxl1 serine/threonine/tyrosine interacting-like 1 increases expression EXP Erythromycin Estolate results in increased expression of STYXL1 mRNA CTD PMID:24412560 NCBI chr12:23,954,563...23,987,155
Ensembl chr12:23,954,574...23,987,271
JBrowse link
G Sugt1 SGT1 homolog, MIS12 kinetochore complex assembly cochaperone increases expression EXP Erythromycin Estolate results in increased expression of SUGT1 mRNA CTD PMID:24412560 NCBI chr15:61,873,158...61,913,983
Ensembl chr15:61,873,056...61,914,072
JBrowse link
G Tgfb3 transforming growth factor, beta 3 decreases expression EXP Erythromycin Estolate results in decreased expression of TGFB3 mRNA CTD PMID:24412560 NCBI chr 6:109,913,757...109,936,217
Ensembl chr 6:109,913,757...109,935,533
JBrowse link
G Thrsp thyroid hormone responsive decreases expression EXP Erythromycin Estolate results in decreased expression of THRSP mRNA CTD PMID:17522070 NCBI chr 1:162,381,251...162,385,575
Ensembl chr 1:162,381,253...162,385,575
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression EXP Erythromycin Estolate results in increased expression of TIMP1 mRNA CTD PMID:17522070 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tmcc1 transmembrane and coiled-coil domain family 1 decreases expression EXP Erythromycin Estolate results in decreased expression of TMCC1 mRNA CTD PMID:24412560 NCBI chr 4:147,920,987...148,048,852
Ensembl chr 4:147,921,724...148,048,726
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 decreases expression EXP Erythromycin Estolate results in decreased expression of TNFAIP3 mRNA CTD PMID:24412560 NCBI chr 1:14,401,103...14,416,369
Ensembl chr 1:14,402,913...14,412,807
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression EXP Erythromycin Estolate results in increased expression of TNFRSF1A mRNA CTD PMID:17522070 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link
G Tp53 tumor protein p53 decreases expression EXP Erythromycin Estolate results in decreased expression of TP53 mRNA CTD PMID:17522070 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tsc22d3 TSC22 domain family, member 3 decreases expression EXP Erythromycin Estolate results in decreased expression of TSC22D3 mRNA CTD PMID:24412560 NCBI chr  X:111,884,285...111,944,693
Ensembl chr  X:111,884,295...111,887,906
JBrowse link
G Ttr transthyretin decreases expression EXP Erythromycin Estolate results in decreased expression of TTR mRNA CTD PMID:17522070 NCBI chr18:15,532,963...15,542,180
Ensembl chr18:15,532,963...15,540,177
JBrowse link
G Txnrd1 thioredoxin reductase 1 decreases expression EXP Erythromycin Estolate results in decreased expression of TXNRD1 mRNA CTD PMID:17522070 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Ugt2a1 UDP glucuronosyltransferase family 2 member A1 increases expression EXP Erythromycin Estolate results in increased expression of UGT2A1 mRNA CTD PMID:24412560 NCBI chr14:22,192,970...22,217,094 JBrowse link
G Zc3h13 zinc finger CCCH type containing 13 increases expression EXP Erythromycin Estolate results in increased expression of ZC3H13 mRNA CTD PMID:24412560 NCBI chr15:57,340,522...57,405,287
Ensembl chr15:57,340,579...57,405,287
JBrowse link
G Zfp354a zinc finger protein 354A decreases expression EXP Erythromycin Estolate results in decreased expression of ZFP354A mRNA CTD PMID:24412560 NCBI chr10:36,586,495...36,600,172
Ensembl chr10:36,589,181...36,600,469
JBrowse link
G Zfp574 zinc finger protein 574 increases expression EXP Erythromycin Estolate results in increased expression of ZFP574 mRNA CTD PMID:24412560 NCBI chr 1:81,952,067...81,957,330
Ensembl chr 1:81,952,067...81,957,329
JBrowse link
everolimus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Everolimus results in decreased activity of ABCB11 protein CTD PMID:23956101 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects stability
affects response to substance
multiple interactions
ISO ABCB1A protein affects the stability of Everolimus
ABCB1 polymorphism affects the susceptibility to Everolimus
bis(4-nitrophenyl)phosphate inhibits the reaction [ABCB1A protein affects the stability of Everolimus]; Everolimus inhibits the reaction [ABCB1A protein affects the metabolism of irinotecan]
CTD PMID:24727322, PMID:27169792 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B affects stability
multiple interactions
ISO ABCB1B protein affects the stability of Everolimus
bis(4-nitrophenyl)phosphate inhibits the reaction [ABCB1B protein affects the stability of Everolimus]; Everolimus inhibits the reaction [ABCB1B protein affects the metabolism of irinotecan]
CTD PMID:24727322 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 affects stability
multiple interactions
ISO ABCG2 protein affects the stability of Everolimus
bis(4-nitrophenyl)phosphate inhibits the reaction [ABCG2 protein affects the stability of Everolimus]; Everolimus inhibits the reaction [ABCG2 protein affects the metabolism of irinotecan]
CTD PMID:24727322 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
decreases phosphorylation
ISO Everolimus results in increased phosphorylation of AKT1 protein
Everolimus results in decreased phosphorylation of AKT1 protein
CTD PMID:16033851, PMID:22885370, PMID:23300809, PMID:28711525 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression
multiple interactions
ISO Everolimus results in decreased expression of BIRC5 protein
Everolimus promotes the reaction [platycodin D results in decreased expression of BIRC5 protein]; navitoclax promotes the reaction [Everolimus results in decreased expression of BIRC5 protein]; platycodin D promotes the reaction [Everolimus results in decreased expression of BIRC5 protein]
CTD PMID:21601561, PMID:28711525, PMID:28947240 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Brd4 bromodomain containing 4 multiple interactions ISO [MYC protein results in decreased susceptibility to Everolimus] promotes the reaction [BRD4 protein binds to MYC gene] CTD PMID:25537515 NCBI chr 7:14,222,101...14,303,055
Ensembl chr 7:14,222,101...14,303,055
JBrowse link
G Casp3 caspase 3 increases cleavage ISO Everolimus results in increased cleavage of CASP3 protein CTD PMID:15940265 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO Everolimus results in decreased expression of CCNA2 protein CTD PMID:16856892 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions
ISO Everolimus results in decreased expression of CCND1 protein
[letrozole co-treated with Everolimus] results in decreased expression of CCND1 protein
CTD PMID:16033851 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd2 cyclin D2 multiple interactions
decreases expression
ISO [letrozole co-treated with Everolimus] results in decreased expression of CCND2 protein
Everolimus results in decreased expression of CCND2 protein
CTD PMID:16033851 NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207
JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO Everolimus results in decreased expression of CCND3 protein CTD PMID:16856892 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Cdh1 cadherin 1 increases expression ISO Everolimus results in increased expression of CDH1 protein CTD PMID:28258630 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Ces1d carboxylesterase 1D decreases activity ISO Everolimus results in decreased activity of CES1 protein CTD PMID:24727322 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Ces2h carboxylesterase 2H decreases activity ISO Everolimus results in decreased activity of CES2 protein CTD PMID:24727322 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156
JBrowse link
G Egfr epidermal growth factor receptor increases expression
multiple interactions
ISO Everolimus results in increased expression of EGFR mRNA; Everolimus results in increased expression of EGFR protein
platycodin D inhibits the reaction [Everolimus results in increased expression of EGFR protein]
CTD PMID:28711525 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E increases phosphorylation
multiple interactions
ISO Everolimus results in increased phosphorylation of EIF4E protein
Everolimus inhibits the reaction [Estradiol results in decreased phosphorylation of EIF4E protein]
CTD PMID:16033851 NCBI chr 2:243,819,616...243,853,987
Ensembl chr 2:243,820,661...243,852,631
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions
decreases phosphorylation
ISO [letrozole co-treated with Everolimus] results in increased phosphorylation of and results in decreased activity of EIF4EBP1 protein; Everolimus inhibits the reaction [Estradiol results in increased phosphorylation of and results in decreased activity of EIF4EBP1 protein]; Everolimus promotes the reaction [platycodin D results in decreased phosphorylation of EIF4EBP1 protein]; Everolimus results in increased phosphorylation of and results in decreased activity of EIF4EBP1 protein; platycodin D promotes the reaction [Everolimus results in decreased phosphorylation of EIF4EBP1 protein] CTD PMID:16033851, PMID:16856892, PMID:16951235, PMID:21372221, PMID:28711525 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Eif4g1 eukaryotic translation initiation factor 4 gamma, 1 multiple interactions ISO Everolimus inhibits the reaction [Estradiol results in increased phosphorylation of EIF4G1 protein] CTD PMID:16033851 NCBI chr11:83,907,659...83,927,683
Ensembl chr11:83,908,109...83,926,524
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO Everolimus promotes the reaction [TNF protein results in increased expression of F3 protein] CTD PMID:19567381 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions
increases expression
ISO platycodin D inhibits the reaction [Everolimus results in increased expression of IGF1R protein]
Everolimus results in increased expression of IGF1R mRNA; Everolimus results in increased expression of IGF1R protein
CTD PMID:28711525 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO Everolimus promotes the reaction [Tretinoin results in increased expression of ITGAM protein] CTD PMID:29743969 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Everolimus inhibits the reaction [4-cresol results in increased expression of MMP9 protein] CTD PMID:30910523 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases activity
ISO
EXP
[Everolimus co-treated with Y 27632] inhibits the reaction [4-cresol results in increased phosphorylation of MTOR protein]; [Letrozole co-treated with Everolimus] inhibits the reaction [Androstenedione affects the activity of MTOR protein]; Everolimus inhibits the reaction [4-cresol results in increased phosphorylation of MTOR protein]; Everolimus inhibits the reaction [Androstenedione affects the activity of MTOR protein]; Everolimus inhibits the reaction [Estradiol affects the activity of MTOR protein]; Everolimus inhibits the reaction [MTOR results in decreased susceptibility to Trabectedin]
Everolimus inhibits the reaction [rhodioloside inhibits the reaction [[cobaltous chloride co-treated with NGF protein] results in decreased phosphorylation of MTOR protein]]
Everolimus results in decreased activity of MTOR; Everolimus results in decreased activity of MTOR protein
CTD PMID:16033851, PMID:20890178, PMID:21622721, PMID:24989011, PMID:30910523 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
decreases response to substance
increases expression
ISO [MYC protein results in decreased susceptibility to Everolimus] promotes the reaction [BRD4 protein binds to MYC gene]
Everolimus results in increased expression of MYC protein
CTD PMID:25537515 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Ngf nerve growth factor multiple interactions EXP Everolimus inhibits the reaction [rhodioloside inhibits the reaction [[cobaltous chloride co-treated with NGF protein] results in decreased phosphorylation of MTOR protein]]; Everolimus inhibits the reaction [rhodioloside inhibits the reaction [[cobaltous chloride co-treated with NGF protein] results in decreased phosphorylation of RPS6KB1 protein]] CTD PMID:24989011 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
decreases expression
ISO Aspirin inhibits the reaction [Everolimus results in decreased expression of NOS3 protein]; cilostazol inhibits the reaction [Everolimus results in decreased expression of NOS3 protein] CTD PMID:19520256 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 decreases activity ISO Everolimus results in decreased activity of NR1I3 protein CTD PMID:30203046 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [navitoclax co-treated with Everolimus] results in increased cleavage of PARP1 protein CTD PMID:28947240 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression EXP Everolimus results in increased expression of PTGS2 mRNA; Everolimus results in increased expression of PTGS2 protein CTD PMID:15937522 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases expression ISO Everolimus results in decreased expression of PTK2 protein modified form CTD PMID:28258630 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions
decreases phosphorylation
ISO [letrozole co-treated with Everolimus] results in decreased phosphorylation of and affects the activity of RB1 protein; Everolimus results in decreased phosphorylation of and affects the activity of RB1 protein
Everolimus results in decreased phosphorylation of RB1 protein
CTD PMID:16033851, PMID:16856892 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rhoa ras homolog family member A decreases expression
multiple interactions
ISO Everolimus results in decreased expression of RHOA protein
[Everolimus co-treated with Y 27632] inhibits the reaction [4-cresol results in increased expression of RHOA protein]
CTD PMID:28258630, PMID:30910523 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Rps6 ribosomal protein S6 multiple interactions
decreases phosphorylation
ISO [letrozole co-treated with Everolimus] results in decreased phosphorylation of RPS6 protein; Everolimus inhibits the reaction [Estradiol results in increased phosphorylation of RPS6 protein]
Everolimus results in decreased phosphorylation of RPS6 protein
CTD PMID:16033851, PMID:21372221, PMID:22885370, PMID:23151917, PMID:23300809, PMID:24386346 NCBI chr 5:105,197,821...105,200,681
Ensembl chr 5:105,197,857...105,200,148
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions EXP
ISO
Everolimus inhibits the reaction [rhodioloside inhibits the reaction [[cobaltous chloride co-treated with NGF protein] results in decreased phosphorylation of RPS6KB1 protein]]
Everolimus inhibits the reaction [Estradiol results in increased phosphorylation of RPS6KB1 protein]; Everolimus inhibits the reaction [TNF protein results in increased phosphorylation of RPS6KB1 protein]
CTD PMID:16033851, PMID:19567381, PMID:24989011 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Sirt1 sirtuin 1 multiple interactions
decreases expression
ISO Aspirin inhibits the reaction [Everolimus results in decreased expression of SIRT1 protein]; cilostazol inhibits the reaction [Everolimus results in decreased expression of SIRT1 protein] CTD PMID:19520256 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase decreases expression ISO Everolimus results in decreased expression of SRC protein modified form CTD PMID:28258630 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Everolimus inhibits the reaction [TNF protein results in increased phosphorylation of RPS6KB1 protein]; Everolimus promotes the reaction [TNF protein results in increased expression of F3 protein] CTD PMID:19567381 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vim vimentin decreases expression ISO Everolimus results in decreased expression of VIM protein CTD PMID:28258630 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
fidaxomicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc51a solute carrier family 51 subunit alpha multiple interactions ISO Fidaxomicin inhibits the reaction [[SLC51A protein binds to SLC51B protein] which results in increased uptake of Glycochenodeoxycholic Acid]; Fidaxomicin inhibits the reaction [[SLC51A protein binds to SLC51B protein] which results in increased uptake of Glycocholic Acid]; Fidaxomicin inhibits the reaction [[SLC51A protein binds to SLC51B protein] which results in increased uptake of Taurochenodeoxycholic Acid]; Fidaxomicin inhibits the reaction [[SLC51A protein binds to SLC51B protein] which results in increased uptake of Taurocholic Acid] CTD PMID:32294204 NCBI chr11:71,533,078...71,547,476
Ensembl chr11:71,533,078...71,547,476
JBrowse link
G Slc51b solute carrier family 51 subunit beta multiple interactions ISO Fidaxomicin inhibits the reaction [[SLC51A protein binds to SLC51B protein] which results in increased uptake of Glycochenodeoxycholic Acid]; Fidaxomicin inhibits the reaction [[SLC51A protein binds to SLC51B protein] which results in increased uptake of Glycocholic Acid]; Fidaxomicin inhibits the reaction [[SLC51A protein binds to SLC51B protein] which results in increased uptake of Taurochenodeoxycholic Acid]; Fidaxomicin inhibits the reaction [[SLC51A protein binds to SLC51B protein] which results in increased uptake of Taurocholic Acid]