Phb2 (prohibitin 2) - Rat Genome Database

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Gene: Phb2 (prohibitin 2) Mus musculus
Analyze
Symbol: Phb2
Name: prohibitin 2
RGD ID: 1558597
MGI Page MGI
Description: Enables sphingolipid binding activity. Involved in several processes, including CD40 signaling pathway; mitophagy; and regulation of gene expression. Acts upstream of or within several processes, including mammary gland development; negative regulation of intracellular estrogen receptor signaling pathway; and negative regulation of mammary gland epithelial cell proliferation. Located in cell surface; mitochondrial inner membrane; and nucleus. Part of mitochondrial prohibitin complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; nose; and respiratory system. Orthologous to human PHB2 (prohibitin 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AU044498; B-cell receptor-associated protein 37; B-cell receptor-associated protein BAP37; BAP; Bap37; Bcap; Bcap37; null; prohibitin-2; R; REA; repressor of estrogen receptor activity
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396124,689,252 - 124,693,908 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6124,689,299 - 124,693,913 (+)EnsemblGRCm39 Ensembl
GRCm386124,712,289 - 124,716,945 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6124,712,336 - 124,716,950 (+)EnsemblGRCm38mm10GRCm38
MGSCv376124,662,307 - 124,666,963 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366124,677,955 - 124,682,537 (+)NCBIMGSCv36mm8
Celera6126,394,014 - 126,398,670 (+)NCBICelera
Cytogenetic Map6F2NCBI
cM Map659.17NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (ISO)
Aroclor 1254  (EXP)
arsenite(3-)  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (ISO)
butan-1-ol  (ISO)
cadmium atom  (ISO)
capsaicin  (ISO)
carbon nanotube  (EXP)
chloroprene  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (EXP)
CU-O LINKAGE  (ISO)
D-glucose  (ISO)
disodium selenite  (ISO)
doxorubicin  (EXP)
fenvalerate  (ISO)
flutamide  (ISO)
folic acid  (EXP)
FR900359  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
furan  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glucose  (ISO)
inositol  (ISO)
ivermectin  (ISO)
L-methionine  (EXP)
lead(0)  (ISO)
mitoxantrone  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
ozone  (ISO)
paracetamol  (ISO)
parathion  (EXP)
PCB138  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (EXP,ISO)
Propiverine  (ISO)
simvastatin  (ISO)
sodium arsenite  (EXP)
sodium fluoride  (EXP)
succimer  (EXP)
tamoxifen  (EXP,ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
trimellitic anhydride  (EXP)
Triptolide  (ISO)
tungsten  (EXP)
zearalenone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6. Ansari-Lari MA, etal., Genome Res 1998 Jan;8(1):29-40.
2. Role of estrogen receptor alpha transcriptional coregulators in tamoxifen resistance in breast cancer. Girault I, etal., Maturitas. 2006 Jul 20;54(4):342-51. Epub 2006 Jul 5.
3. Coregulators in nuclear estrogen receptor action: from concept to therapeutic targeting. Hall JM and McDonnell DP, Mol Interv. 2005 Dec;5(6):343-57.
4. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. MGD IEA MGD IEA
8. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
9. The regulation of mitochondrial morphology: intricate mechanisms and dynamic machinery. Palmer CS, etal., Cell Signal. 2011 Oct;23(10):1534-45. doi: 10.1016/j.cellsig.2011.05.021. Epub 2011 Jun 13.
10. Mouse MP Annotation Import Pipeline RGD automated import pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Expression of PHB2 in rat brain cortex following traumatic brain injury. Xu T, etal., Int J Mol Sci. 2014 Feb 21;15(2):3299-318. doi: 10.3390/ijms15023299.
Additional References at PubMed
PMID:8070406   PMID:9798653   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11302691   PMID:12477932   PMID:12865426   PMID:12878603   PMID:12904583   PMID:14610273  
PMID:14651853   PMID:14681479   PMID:15140878   PMID:15173318   PMID:15713652   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16602821   PMID:17065319   PMID:17785450   PMID:17932104  
PMID:18281461   PMID:18287559   PMID:18339324   PMID:18614015   PMID:18614564   PMID:18835980   PMID:19329436   PMID:20959514   PMID:21267068   PMID:21565611   PMID:21677750   PMID:21689744  
PMID:21780252   PMID:21862609   PMID:21873635   PMID:22417827   PMID:22479600   PMID:22585830   PMID:23144624   PMID:23241883   PMID:23392257   PMID:23665500   PMID:23863811   PMID:23937658  
PMID:24457600   PMID:24709813   PMID:24710105   PMID:24856930   PMID:24952961   PMID:25643582   PMID:25737280   PMID:25769926   PMID:26383514   PMID:26497683   PMID:26653759   PMID:26783299  
PMID:26885862   PMID:27034005   PMID:27105734   PMID:27160897   PMID:27507650   PMID:28017329   PMID:28187984   PMID:28378742   PMID:28671696   PMID:29111324   PMID:29530978   PMID:29867124  
PMID:30068389   PMID:30196744   PMID:30550785   PMID:30562941   PMID:31285263   PMID:31537525   PMID:32581705   PMID:33230847   PMID:34903570   PMID:36114006   PMID:36200440   PMID:36379251  
PMID:36417873   PMID:36808153   PMID:36878279   PMID:37451140   PMID:37781037   PMID:37839992   PMID:38322592   PMID:38351062   PMID:38464826  


Genomics

Comparative Map Data
Phb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396124,689,252 - 124,693,908 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6124,689,299 - 124,693,913 (+)EnsemblGRCm39 Ensembl
GRCm386124,712,289 - 124,716,945 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6124,712,336 - 124,716,950 (+)EnsemblGRCm38mm10GRCm38
MGSCv376124,662,307 - 124,666,963 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366124,677,955 - 124,682,537 (+)NCBIMGSCv36mm8
Celera6126,394,014 - 126,398,670 (+)NCBICelera
Cytogenetic Map6F2NCBI
cM Map659.17NCBI
PHB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38126,965,327 - 6,970,753 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl126,965,327 - 6,970,780 (-)EnsemblGRCh38hg38GRCh38
GRCh37127,074,490 - 7,079,916 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,944,778 - 6,950,152 (-)NCBINCBI36Build 36hg18NCBI36
Celera128,695,534 - 8,700,935 (-)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef126,932,980 - 6,938,381 (-)NCBIHuRef
CHM1_1127,073,468 - 7,078,869 (-)NCBICHM1_1
T2T-CHM13v2.0126,978,802 - 6,984,228 (-)NCBIT2T-CHM13v2.0
Phb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84159,203,948 - 159,208,561 (+)NCBIGRCr8
mRatBN7.24157,517,662 - 157,522,268 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4157,517,577 - 157,522,272 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4163,746,152 - 163,750,758 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04159,529,057 - 159,533,663 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04158,170,622 - 158,175,227 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04157,230,769 - 157,235,375 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4157,230,769 - 157,235,367 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04224,248,365 - 224,252,971 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44160,835,328 - 160,839,933 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14161,080,337 - 161,084,834 (+)NCBI
Celera4146,256,324 - 146,260,930 (+)NCBICelera
Cytogenetic Map4q42NCBI
Phb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554134,558,259 - 4,563,582 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554134,557,969 - 4,563,697 (-)NCBIChiLan1.0ChiLan1.0
PHB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21012,531,341 - 12,536,545 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11212,528,100 - 12,533,303 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0127,097,073 - 7,102,474 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1127,012,862 - 7,018,303 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl127,013,195 - 7,018,053 (-)Ensemblpanpan1.1panPan2
PHB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12738,075,769 - 38,080,440 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2738,075,652 - 38,080,109 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha278,536,250 - 8,540,926 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02738,428,364 - 38,433,040 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2738,428,395 - 38,433,026 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12738,303,246 - 38,307,922 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02738,344,227 - 38,348,903 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0278,015,013 - 8,019,689 (-)NCBIUU_Cfam_GSD_1.0
Phb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945102,186,944 - 102,191,636 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936709854,698 - 858,851 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936709854,493 - 859,182 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PHB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl563,751,558 - 63,756,478 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1563,751,566 - 63,756,480 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2566,187,707 - 66,192,621 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PHB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1116,998,517 - 7,004,437 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660631,213,103 - 1,219,227 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Phb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248603,599,687 - 3,604,872 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248603,599,435 - 3,605,016 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Phb2
150 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1403
Count of miRNA genes:574
Interacting mature miRNAs:710
Transcripts:ENSMUST00000004375, ENSMUST00000124779, ENSMUST00000129422, ENSMUST00000130279, ENSMUST00000143000, ENSMUST00000145447, ENSMUST00000147974, ENSMUST00000150847
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300887Pabr1_mplasma apolipoprotein B (human) regulator 1 (mouse)Not determined6103754405136400690Mouse
1300704Cia3_mcollagen induced arthritis QTL 3 (mouse)Not determined696324286130324483Mouse
1301244Ichs_mimmediate cutaneous hypersensitivity QTL (mouse)Not determined690772571124772807Mouse
1301083Bhr5_mbronchial hyperresponsiveness 5 (mouse)Not determined6115694477132578150Mouse
1301152Athsq2_matherosclerosis susceptibility QTL 2 (mouse)Not determined6117059949149588044Mouse
1301292Cfbw2_mcystic fibrosis body weight 2 (mouse)Not determined694981612128981699Mouse
1301658Radpf3_mradiation pulmonary fibrosis 3 (mouse)Not determined6115219814146330736Mouse
1301509Sluc3_msusceptibility to lung cancer 3 (mouse)Not determined6104480321127019938Mouse
1301518Bbaa5_mB.burgdorferi-associated arthritis 5 (mouse)Not determined698483798145881170Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648703490125333748Mouse
1301804Bulb2_mbulb size 2 (mouse)Not determined6120416806149588044Mouse
1301915Chab3_mcholesterol absorption 3 (mouse)Not determined698908709132916997Mouse
1301923Lith6_mlithogenic gene 6 (mouse)Not determined698694477132694676Mouse
1301927Etohcta6_methanol conditioned taste aversion 6 (mouse)Not determined6115578005149578150Mouse
1357555Tesq2_mtestis weight QTL 2 (mouse)Not determined696632912146535124Mouse
1302131Bmd8_mbone mineral density 8 (mouse)Not determined699132089133132228Mouse
1357806Aaj3_manxiety in A/J 3 (mouse)Not determined6104480321136400690Mouse
4140980Mvwf2_mmodifier of von Willebrand factor 2 (mouse)Not determined114345693145601739Mouse
4141194Cyx_mcycloheximide tasting (mouse)Not determined115546805149549364Mouse
4141064Ath37_matherosclerosis 37 (mouse)Not determined6116641858128495988Mouse
4141295Rua_mraffinose acetate tasting (mouse)Not determined115546805149549364Mouse
4141889Qui_mquinine sensitivity, taste (mouse)Not determined115546805149549364Mouse
4141940W6q5_mweight 6 weeks QTL 5 (mouse)Not determined96632912146535124Mouse
4142079Skmw15_mskeletal muscle weight 15 (mouse)Not determined6116829851149588044Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46912919136400690Mouse
4142416Egq11_mearly growth QTL 11 (mouse)Not determined96632912146535124Mouse
11252138Clas1_mcarcinogen-induced lung adenoma susceptibility 1 (mouse)6112246918146954059Mouse
11353842Bmiq4_mbody mass index QTL 4 (mouse)692584287146330736Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683690851146954059Mouse
10043891Tilss4_mTNF-induced lethal shock susceptibility 3 (mouse)Not determined6112246918125333748Mouse
10043923Bhr7_mbronchial hyperresponsiveness 7 (mouse)Not determined698219814132219938Mouse
10449436Pas17_mpulmonary adenoma susceptibility 17 (mouse)6124334273145601739Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645290993128811995Mouse
11040599Lmr4b_mleishmaniasis resistance 4b (mouse)696324286130324483Mouse
10412207Cypr5_mcytokine production 5 (mouse)Not determined6110815180144815323Mouse
13463481Mcvq14_mmean corpuscular volume QTL 14 (mouse)6111142448145142541Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673476983134676963Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648696934125336963Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648696934148351498Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse

Markers in Region
RH126903  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386124,716,733 - 124,716,934UniSTSGRCm38
MGSCv376124,666,751 - 124,666,952UniSTSGRCm37
Celera6126,398,458 - 126,398,659UniSTS
Cytogenetic Map6F2UniSTS
cM Map660.22UniSTS
Whitehead/MRC_RH61268.0UniSTS
Phb2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6F2UniSTS
cM Map659.17UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_007531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC002397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC164157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK002334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK090088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK132052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK132058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK135729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK158423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK207747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK218588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY211613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY319418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB595613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC145875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D49684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U89422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X78683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000004375   ⟹   ENSMUSP00000004375
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6124,689,299 - 124,693,913 (+)Ensembl
GRCm38.p6 Ensembl6124,712,336 - 124,716,950 (+)Ensembl
RefSeq Acc Id: ENSMUST00000124779
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6124,689,299 - 124,690,833 (+)Ensembl
GRCm38.p6 Ensembl6124,712,336 - 124,713,870 (+)Ensembl
RefSeq Acc Id: ENSMUST00000129422
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6124,692,326 - 124,693,502 (+)Ensembl
GRCm38.p6 Ensembl6124,715,363 - 124,716,539 (+)Ensembl
RefSeq Acc Id: ENSMUST00000130279   ⟹   ENSMUSP00000121535
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6124,690,085 - 124,693,603 (+)Ensembl
GRCm38.p6 Ensembl6124,713,122 - 124,716,640 (+)Ensembl
RefSeq Acc Id: ENSMUST00000143000
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6124,692,311 - 124,693,913 (+)Ensembl
GRCm38.p6 Ensembl6124,715,348 - 124,716,950 (+)Ensembl
RefSeq Acc Id: ENSMUST00000145447
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6124,689,299 - 124,693,913 (+)Ensembl
GRCm38.p6 Ensembl6124,712,336 - 124,716,950 (+)Ensembl
RefSeq Acc Id: ENSMUST00000147974   ⟹   ENSMUSP00000119316
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6124,689,729 - 124,691,763 (+)Ensembl
GRCm38.p6 Ensembl6124,712,766 - 124,714,800 (+)Ensembl
RefSeq Acc Id: ENSMUST00000150847
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6124,689,299 - 124,690,031 (+)Ensembl
GRCm38.p6 Ensembl6124,712,336 - 124,713,068 (+)Ensembl
RefSeq Acc Id: NM_007531   ⟹   NP_031557
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396124,689,252 - 124,693,908 (+)NCBI
GRCm386124,712,289 - 124,716,945 (+)NCBI
MGSCv376124,662,307 - 124,666,963 (+)RGD
Celera6126,394,014 - 126,398,670 (+)RGD
cM Map6 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_031557   ⟸   NM_007531
- UniProtKB: O89075 (UniProtKB/Swiss-Prot),   Q61336 (UniProtKB/Swiss-Prot),   O35129 (UniProtKB/Swiss-Prot),   Q3V235 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000121535   ⟸   ENSMUST00000130279
RefSeq Acc Id: ENSMUSP00000119316   ⟸   ENSMUST00000147974
RefSeq Acc Id: ENSMUSP00000004375   ⟸   ENSMUST00000004375
Protein Domains
Band

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35129-F1-model_v2 AlphaFold O35129 1-299 view protein structure

Promoters
RGD ID:6839238
Promoter ID:MM_KWN:47552
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000100958,   NM_007531,   NM_013536,   OTTMUST00000048977,   OTTMUST00000048978,   OTTMUST00000048980,   OTTMUST00000057563,   OTTMUST00000057564,   OTTMUST00000067270,   OTTMUST00000067271,   UC009DRH.1,   UC009DRI.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv366124,662,026 - 124,663,437 (-)MPROMDB
RGD ID:6839741
Promoter ID:MM_KWN:47553
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   ES_Cell,   Kidney,   Liver,   Lung
Transcripts:OTTMUST00000048981,   OTTMUST00000067272
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv366124,664,456 - 124,665,697 (+)MPROMDB
RGD ID:6891020
Promoter ID:EPDNEW_M8938
Type:initiation region
Name:Phb2_1
Description:Mus musculus prohibitin 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm386124,712,321 - 124,712,381EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:102520 AgrOrtholog
Ensembl Genes ENSMUSG00000004264 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000004375 ENTREZGENE
  ENSMUST00000004375.16 UniProtKB/Swiss-Prot
  ENSMUST00000130279.2 UniProtKB/TrEMBL
  ENSMUST00000147974.8 UniProtKB/TrEMBL
Gene3D-CATH 3.30.479.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.250.2090 UniProtKB/TrEMBL
InterPro Band_7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Band_7/SPFH_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prohibitin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12034 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:102520 ENTREZGENE
NCBI Gene 12034 ENTREZGENE
PANTHER PROHIBITIN-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23222 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Band_7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Phb2 PhenoGen
PRINTS PROHIBITIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PHB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF117892 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F6Q8V7_MOUSE UniProtKB/TrEMBL
  F6QPR1_MOUSE UniProtKB/TrEMBL
  O35129 ENTREZGENE
  O89075 ENTREZGENE
  PHB2_MOUSE UniProtKB/Swiss-Prot
  Q3V235 ENTREZGENE, UniProtKB/TrEMBL
  Q3V2V2_MOUSE UniProtKB/TrEMBL
  Q61336 ENTREZGENE
UniProt Secondary O89075 UniProtKB/Swiss-Prot
  Q61336 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-26 Phb2  prohibitin 2  Bcap37    Data merged from RGD:734178 737654 PROVISIONAL