Phb2 (prohibitin 2) - Rat Genome Database

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Gene: Phb2 (prohibitin 2) Ictidomys tridecemlineatus
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Symbol: Phb2
Name: prohibitin 2
RGD ID: 12627754
Description: ENCODES a protein that exhibits amide binding (ortholog); identical protein binding (ortholog); protein C-terminus binding (ortholog); INVOLVED IN activation of phospholipase C activity (ortholog); activation of protein kinase C activity (ortholog); antiviral innate immune response (ortholog); PARTICIPATES IN estrogen signaling pathway; mitochondria fusion pathway; tamoxifen pharmacodynamics pathway; ASSOCIATED WITH Brain Injuries (ortholog); developmental and epileptic encephalopathy 21 (ortholog); Hyperphosphatemic Familial Tumoral Calcinosis 1 (ortholog); FOUND IN axon (ortholog); cell periphery (ortholog); cell surface (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: prohibitin-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945102,186,944 - 102,191,636 (+)NCBI
SpeTri2.0NW_004936709854,493 - 859,182 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of phospholipase C activity  (ISO)
activation of protein kinase C activity  (ISO)
antiviral innate immune response  (ISO)
B cell activation  (ISO)
CD40 signaling pathway  (ISO)
cell migration  (ISO)
cellular response to hypoxia  (ISO)
cellular response to retinoic acid  (ISO)
mammary gland alveolus development  (ISO)
mammary gland branching involved in thelarche  (ISO)
mitochondrion organization  (ISO)
mitophagy  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of intracellular estrogen receptor signaling pathway  (ISO)
negative regulation of mammary gland epithelial cell proliferation  (ISO)
negative regulation of transcription, DNA-templated  (ISO)
positive regulation of cell cycle G1/S phase transition  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of exit from mitosis  (ISO)
positive regulation of immunoglobulin production  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of NIK/NF-kappaB signaling  (ISO)
protein import into nucleus  (ISO)
protein stabilization  (ISO)
regulation of branching involved in mammary gland duct morphogenesis  (ISO)
regulation of cardiolipin metabolic process  (ISO)
regulation of complement activation  (ISO)
regulation of cytochrome-c oxidase activity  (ISO)
response to wounding  (ISO)
RIG-I signaling pathway  (ISO)
sister chromatid cohesion  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
Phb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945102,186,944 - 102,191,636 (+)NCBI
SpeTri2.0NW_004936709854,493 - 859,182 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PHB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl126,965,327 - 6,970,780 (-)EnsemblGRCh38hg38GRCh38
GRCh38126,965,327 - 6,970,753 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37127,074,490 - 7,079,916 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,944,778 - 6,950,152 (-)NCBINCBI36hg18NCBI36
Celera128,695,534 - 8,700,935 (-)NCBI
Cytogenetic Map12p13.31NCBI
HuRef126,932,980 - 6,938,381 (-)NCBIHuRef
CHM1_1127,073,468 - 7,078,869 (-)NCBICHM1_1
Phb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396124,689,252 - 124,693,908 (+)NCBIGRCm39mm39
GRCm39 Ensembl6124,689,299 - 124,693,913 (+)Ensembl
GRCm386124,712,289 - 124,716,945 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6124,712,336 - 124,716,950 (+)EnsemblGRCm38mm10GRCm38
MGSCv376124,662,307 - 124,666,963 (+)NCBIGRCm37mm9NCBIm37
MGSCv366124,677,955 - 124,682,537 (+)NCBImm8
Celera6126,394,014 - 126,398,670 (+)NCBICelera
Cytogenetic Map6F2NCBI
cM Map659.17NCBI
Phb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24157,517,662 - 157,522,268 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl4157,517,577 - 157,522,272 (+)Ensembl
Rnor_6.04157,230,769 - 157,235,375 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4157,230,769 - 157,235,367 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04224,248,365 - 224,252,971 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44160,835,328 - 160,839,933 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14161,080,337 - 161,084,834 (+)NCBI
Celera4146,256,324 - 146,260,930 (+)NCBICelera
Cytogenetic Map4q42NCBI
Phb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554134,558,259 - 4,563,582 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554134,557,969 - 4,563,697 (-)NCBIChiLan1.0ChiLan1.0
PHB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1127,012,862 - 7,018,303 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl127,013,195 - 7,018,053 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0127,097,073 - 7,102,474 (-)NCBIMhudiblu_PPA_v0panPan3
PHB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12738,075,769 - 38,080,440 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2738,075,652 - 38,080,109 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha278,536,250 - 8,540,926 (-)NCBI
ROS_Cfam_1.02738,428,364 - 38,433,040 (+)NCBI
UMICH_Zoey_3.12738,303,246 - 38,307,922 (+)NCBI
UNSW_CanFamBas_1.02738,344,227 - 38,348,903 (+)NCBI
UU_Cfam_GSD_1.0278,015,013 - 8,019,689 (-)NCBI
PHB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl563,751,558 - 63,756,478 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1563,751,566 - 63,756,480 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2566,187,707 - 66,192,621 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PHB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1116,998,517 - 7,004,437 (-)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660631,213,103 - 1,219,227 (+)NCBIVero_WHO_p1.0
Phb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248603,599,435 - 3,605,016 (-)NCBIHetGla_female_1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005338308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: XM_005338308   ⟹   XP_005338365
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404945102,186,944 - 102,191,636 (+)NCBI
SpeTri2.0NW_004936709854,493 - 859,182 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005338365 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein KAG3292496 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005338365   ⟸   XM_005338308
- UniProtKB: I3N9G0 (UniProtKB/TrEMBL)
- Sequence:


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000027814 ENTREZGENE
Ensembl Protein ENSSTOP00000021006 ENTREZGENE
NCBI Gene Phb2 ENTREZGENE
UniProt I3N9G0 ENTREZGENE