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Gene: PHB2 (prohibitin 2) Homo sapiens
Symbol: PHB2
Name: prohibitin 2
RGD ID: 1604641
Description: Exhibits several functions, including protein C-terminus binding activity; protein N-terminus binding activity; and protein dimerization activity. Involved in several processes, including defense response to virus; positive regulation of cell cycle phase transition; and regulation of transcription, DNA-templated. Localizes to several cellular components, including cell surface; mitochondrial membrane; and nuclear matrix; PARTICIPATES IN estrogen signaling pathway; mitochondria fusion pathway; tamoxifen pharmacodynamics pathway; INTERACTS WITH 17beta-estradiol; acetylsalicylic acid; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: B-cell associated protein; B-cell receptor-associated protein BAP37; BAP; Bap37; BCAP37; D-prohibitin; hBAP; MGC117268; p22; PNAS-141; prohibitin-2; REA; repressor of estrogen receptor activity
Mus musculus (house mouse) : Phb2 (prohibitin 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Phb2 (prohibitin 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Phb2 (prohibitin 2)
Pan paniscus (bonobo/pygmy chimpanzee) : PHB2 (prohibitin 2)
Canis lupus familiaris (dog) : PHB2 (prohibitin 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Phb2 (prohibitin 2)
Sus scrofa (pig) : PHB2 (prohibitin 2)
Chlorocebus sabaeus (African green monkey) : PHB2 (prohibitin 2)
Heterocephalus glaber (naked mole-rat) : Phb2 (prohibitin 2)
more info ...
Related Pseudogenes: PHB2P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl126,965,327 - 6,970,753 (-)EnsemblGRCh38hg38GRCh38
GRCh38126,965,327 - 6,970,753 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37127,074,515 - 7,079,981 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,944,778 - 6,950,152 (-)NCBINCBI36hg18NCBI36
Celera128,695,534 - 8,700,935 (-)NCBI
Cytogenetic Map12p13.31NCBI
HuRef126,932,980 - 6,938,381 (-)NCBIHuRef
CHM1_1127,073,468 - 7,078,869 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on PHB2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1604641
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2020-10-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.