PHB2 (prohibitin 2) - Rat Genome Database

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Gene: PHB2 (prohibitin 2) Pan paniscus
Analyze
Symbol: PHB2
Name: prohibitin 2
RGD ID: 11828486
Description: ENCODES a protein that exhibits amide binding (inferred); identical protein binding (inferred); protein heterodimerization activity (inferred); INVOLVED IN cellular response to hypoxia (ortholog); cellular response to retinoic acid (ortholog); intracellular estrogen receptor signaling pathway (ortholog); PARTICIPATES IN estrogen signaling pathway; mitochondria fusion pathway; tamoxifen pharmacodynamics pathway; ASSOCIATED WITH Brain Injuries (ortholog); developmental and epileptic encephalopathy 21 (ortholog); genetic disease (ortholog); FOUND IN axon (ortholog); GABA-ergic synapse (ortholog); glutamatergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: prohibitin-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21012,531,341 - 12,536,545 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11212,528,100 - 12,533,303 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0127,097,073 - 7,102,474 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1127,012,862 - 7,018,303 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl127,013,195 - 7,018,053 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PHB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21012,531,341 - 12,536,545 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11212,528,100 - 12,533,303 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0127,097,073 - 7,102,474 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1127,012,862 - 7,018,303 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl127,013,195 - 7,018,053 (-)Ensemblpanpan1.1panPan2
PHB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38126,965,327 - 6,970,753 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl126,965,327 - 6,970,780 (-)EnsemblGRCh38hg38GRCh38
GRCh37127,074,490 - 7,079,916 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,944,778 - 6,950,152 (-)NCBINCBI36Build 36hg18NCBI36
Celera128,695,534 - 8,700,935 (-)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef126,932,980 - 6,938,381 (-)NCBIHuRef
CHM1_1127,073,468 - 7,078,869 (-)NCBICHM1_1
T2T-CHM13v2.0126,978,802 - 6,984,228 (-)NCBIT2T-CHM13v2.0
Phb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396124,689,252 - 124,693,908 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6124,689,299 - 124,693,913 (+)EnsemblGRCm39 Ensembl
GRCm386124,712,289 - 124,716,945 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6124,712,336 - 124,716,950 (+)EnsemblGRCm38mm10GRCm38
MGSCv376124,662,307 - 124,666,963 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366124,677,955 - 124,682,537 (+)NCBIMGSCv36mm8
Celera6126,394,014 - 126,398,670 (+)NCBICelera
Cytogenetic Map6F2NCBI
cM Map659.17NCBI
Phb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84159,203,948 - 159,208,561 (+)NCBIGRCr8
mRatBN7.24157,517,662 - 157,522,268 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4157,517,577 - 157,522,272 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4163,746,152 - 163,750,758 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04159,529,057 - 159,533,663 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04158,170,622 - 158,175,227 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04157,230,769 - 157,235,375 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4157,230,769 - 157,235,367 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04224,248,365 - 224,252,971 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44160,835,328 - 160,839,933 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14161,080,337 - 161,084,834 (+)NCBI
Celera4146,256,324 - 146,260,930 (+)NCBICelera
Cytogenetic Map4q42NCBI
Phb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554134,558,259 - 4,563,582 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554134,557,969 - 4,563,697 (-)NCBIChiLan1.0ChiLan1.0
PHB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12738,075,769 - 38,080,440 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2738,075,652 - 38,080,109 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha278,536,250 - 8,540,926 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02738,428,364 - 38,433,040 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2738,428,395 - 38,433,026 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12738,303,246 - 38,307,922 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02738,344,227 - 38,348,903 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0278,015,013 - 8,019,689 (-)NCBIUU_Cfam_GSD_1.0
Phb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945102,186,944 - 102,191,636 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936709854,698 - 858,851 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936709854,493 - 859,182 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PHB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl563,751,558 - 63,756,478 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1563,751,566 - 63,756,480 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2566,187,707 - 66,192,621 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PHB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1116,998,517 - 7,004,437 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660631,213,103 - 1,219,227 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Phb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248603,599,687 - 3,604,872 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248603,599,435 - 3,605,016 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000051101   ⟹   ENSPPAP00000028255
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl127,013,195 - 7,018,053 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000051106   ⟹   ENSPPAP00000028260
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl127,013,195 - 7,018,053 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000051109   ⟹   ENSPPAP00000028263
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl127,013,202 - 7,018,053 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000051114   ⟹   ENSPPAP00000028268
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl127,013,959 - 7,018,053 (-)Ensembl
RefSeq Acc Id: XM_055095329   ⟹   XP_054951304
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21012,531,341 - 12,536,545 (-)NCBI
NHGRI_mPanPan11212,528,100 - 12,533,303 (-)NCBI
Protein Sequences
Protein RefSeqs XP_054951304 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000028255.1
  ENSPPAP00000028260.1
  ENSPPAP00000028263.1
  ENSPPAP00000028268.1
Reference Protein Sequences
RefSeq Acc Id: ENSPPAP00000028260   ⟸   ENSPPAT00000051106
RefSeq Acc Id: ENSPPAP00000028255   ⟸   ENSPPAT00000051101
RefSeq Acc Id: ENSPPAP00000028268   ⟸   ENSPPAT00000051114
RefSeq Acc Id: ENSPPAP00000028263   ⟸   ENSPPAT00000051109
RefSeq Acc Id: XP_054951304   ⟸   XM_055095329
- UniProtKB: A0A2R9BG79 (UniProtKB/TrEMBL)
Protein Domains
Band


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000037135 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000051101.1 UniProtKB/TrEMBL
  ENSPPAT00000051106.1 UniProtKB/TrEMBL
  ENSPPAT00000051109.1 UniProtKB/TrEMBL
  ENSPPAT00000051114.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.479.30 UniProtKB/TrEMBL
InterPro Band_7 UniProtKB/TrEMBL
  Band_7/SPFH_dom_sf UniProtKB/TrEMBL
  Prohibitin UniProtKB/TrEMBL
KEGG Report pps:100992543 UniProtKB/TrEMBL
NCBI Gene PHB2 ENTREZGENE
PANTHER PROHIBITIN-2 UniProtKB/TrEMBL
  PTHR23222 UniProtKB/TrEMBL
Pfam Band_7 UniProtKB/TrEMBL
PRINTS PROHIBITIN UniProtKB/TrEMBL
SMART PHB UniProtKB/TrEMBL
Superfamily-SCOP SSF117892 UniProtKB/TrEMBL
UniProt A0A2R9BF37_PANPA UniProtKB/TrEMBL
  A0A2R9BF41_PANPA UniProtKB/TrEMBL
  A0A2R9BG79 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BG85_PANPA UniProtKB/TrEMBL