Bmp3 (bone morphogenetic protein 3) - Rat Genome Database

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Gene: Bmp3 (bone morphogenetic protein 3) Mus musculus
Analyze
Symbol: Bmp3
Name: bone morphogenetic protein 3
RGD ID: 731333
MGI Page MGI
Description: Predicted to have BMP receptor binding activity; cytokine activity; and growth factor activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to localize to extracellular space and vesicle. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; skeleton; and urinary system. Orthologous to human BMP3 (bone morphogenetic protein 3).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 9130206H07; 9530029I04Rik; BMP-3; D630004D15R; D630004D15Rik; RIKEN cDNA D630004D15 gene
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39599,002,274 - 99,031,912 (+)NCBIGRCm39mm39
GRCm39 Ensembl599,002,274 - 99,032,255 (+)Ensembl
GRCm38598,854,415 - 98,884,053 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl598,854,415 - 98,884,396 (+)EnsemblGRCm38mm10GRCm38
MGSCv37599,283,458 - 99,309,979 (+)NCBIGRCm37mm9NCBIm37
MGSCv36599,094,741 - 99,120,430 (+)NCBImm8
Celera596,176,773 - 96,203,304 (+)NCBICelera
Cytogenetic Map5E3NCBI
cM Map548.24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:1460021   PMID:1468569   PMID:1869533   PMID:1904008   PMID:1970330   PMID:7789186   PMID:7811286   PMID:8661727   PMID:8808404   PMID:8985317   PMID:9056639   PMID:9415424  
PMID:9664685   PMID:10349636   PMID:10462412   PMID:10465785   PMID:10515202   PMID:10716617   PMID:11042159   PMID:11076861   PMID:11138004   PMID:11165481   PMID:11217851   PMID:11714677  
PMID:12477932   PMID:12666204   PMID:14691545   PMID:14973297   PMID:15342483   PMID:15963767   PMID:16141072   PMID:16141073   PMID:16151852   PMID:16602821   PMID:16818445   PMID:17066377  
PMID:17286598   PMID:17662325   PMID:18287559   PMID:18331343   PMID:19653325   PMID:20713518   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22074949   PMID:22560297   PMID:22682244  
PMID:23293290   PMID:23451274   PMID:24154525   PMID:24333131   PMID:24952961   PMID:26489765   PMID:26982203   PMID:27986952   PMID:28558017   PMID:28731788   PMID:30228991   PMID:30352686  
PMID:31669249   PMID:32325033  


Genomics

Comparative Map Data
Bmp3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39599,002,274 - 99,031,912 (+)NCBIGRCm39mm39
GRCm39 Ensembl599,002,274 - 99,032,255 (+)Ensembl
GRCm38598,854,415 - 98,884,053 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl598,854,415 - 98,884,396 (+)EnsemblGRCm38mm10GRCm38
MGSCv37599,283,458 - 99,309,979 (+)NCBIGRCm37mm9NCBIm37
MGSCv36599,094,741 - 99,120,430 (+)NCBImm8
Celera596,176,773 - 96,203,304 (+)NCBICelera
Cytogenetic Map5E3NCBI
cM Map548.24NCBI
BMP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl481,030,708 - 81,057,627 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl481,030,708 - 81,057,632 (+)EnsemblGRCh38hg38GRCh38
GRCh38481,030,708 - 81,057,627 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37481,951,862 - 81,978,781 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36482,171,143 - 82,197,709 (+)NCBINCBI36hg18NCBI36
Build 34482,309,297 - 82,331,904NCBI
Celera479,245,158 - 79,271,726 (+)NCBI
Cytogenetic Map4q21.21NCBI
HuRef477,696,010 - 77,722,586 (+)NCBIHuRef
CHM1_1481,928,619 - 81,955,186 (+)NCBICHM1_1
Bmp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21410,712,489 - 10,737,153 (-)NCBI
Rnor_6.0 Ensembl1412,359,363 - 12,387,102 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01412,362,912 - 12,387,572 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01412,306,370 - 12,331,030 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41412,065,635 - 12,090,295 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11412,065,634 - 12,090,295 (-)NCBI
Celera1410,801,184 - 10,825,826 (-)NCBICelera
Cytogenetic Map14p22NCBI
Bmp3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554335,211,592 - 5,246,194 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554335,194,312 - 5,246,125 (+)NCBIChiLan1.0ChiLan1.0
BMP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1448,992,172 - 49,018,780 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl448,992,266 - 49,019,205 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0443,143,784 - 43,170,854 (-)NCBIMhudiblu_PPA_v0panPan3
BMP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1325,206,040 - 5,233,848 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl325,207,833 - 5,231,966 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3236,645,845 - 36,674,004 (-)NCBI
ROS_Cfam_1.0325,238,247 - 5,266,418 (+)NCBI
UMICH_Zoey_3.1325,267,894 - 5,294,547 (+)NCBI
UNSW_CanFamBas_1.0325,175,043 - 5,202,995 (+)NCBI
UU_Cfam_GSD_1.03234,764,153 - 34,792,337 (-)NCBI
Bmp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244052857,106,302 - 7,130,557 (-)NCBI
SpeTri2.0NW_0049367491,025,867 - 1,053,578 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BMP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8136,880,456 - 136,905,263 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18136,880,456 - 136,904,739 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28146,174,734 - 146,199,020 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BMP3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1729,454,394 - 29,482,560 (+)NCBI
ChlSab1.1 Ensembl729,455,761 - 29,482,896 (+)Ensembl
Bmp3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247579,952,847 - 9,980,259 (-)NCBI

Position Markers
Bmp3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38598,872,030 - 98,872,410UniSTSGRCm38
MGSCv37599,301,049 - 99,301,429UniSTSGRCm37
Celera596,194,368 - 96,194,748UniSTS
Cytogenetic Map5E3UniSTS
cM Map555.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526236236138457140Mouse
4140990Lgq6_mlate growth QTL 6 (mouse)Not determined31975890100630065Mouse
4141219W10q16_mweight 10 weeks QTL 16 (mouse)Not determined31975890100630065Mouse
1301524Lmb2_mlupus in MRL and B6 F2 cross (mouse)Not determined537424144112317856Mouse
11041665Lmr24_mleishmaniasis resistance 24 (mouse)552537120107173175Mouse
11041899Lmr24a_mleishmaniasis resistance 24a (mouse)552537120107173175Mouse
4142064Tmc1m4_mTmc1 modifier 4 (mouse)Not determined554342835126924008Mouse
1301243Bmd2_mbone mineral density 2 (mouse)Not determined555230992100307666Mouse
4142317Rgcs1_mretinal ganglion cell susceptible 1 (mouse)Not determined55230992108614761Mouse
10045972Tir5_mtrypanosome infection response 5 (mouse)Not determined563548099104239199Mouse
12904739M2fscn2_mmodifier 2 of FSCN2 (mouse)566381814100381814Mouse
12904740M1fscn2_mmodifier 1 of Fscn2 (mouse)566381814100381814Mouse
26884395Humsd2_mhumerus midshaft diameter 2, 10 week (mouse)569900000132500000Mouse
10043993Hbnr10_mHeligmosomoides bakeri nematode resistance 10 (mouse)Not determined572271017106271152Mouse
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572700000140000000Mouse
13506928Recrq8_mrecombination rate in male meiosis QTL 8 (mouse)574300000132500000Mouse
25314315Mlh1fc4_mMLH1 foci count 4 (mouse)574300000132500000Mouse
1357431Cia27_mcollagen induced arthritis 27 (mouse)Not determined575154687119880564Mouse
4141438Skmw13_mskeletal muscle weight 13 (mouse)Not determined576042404110042620Mouse
4141505Chlq14_mcirculating hormone level QTL 14 (mouse)Not determined576132927110133058Mouse
1301691Cdcs10_mcytokine deficiency colitis susceptibility 10 (mouse)Not determined576132927110133058Mouse
1300986Hdlq2_mHDL QTL 2 (mouse)Not determined576132927110133058Mouse
1300931Cocrb6_mcocaine related behavior 6 (mouse)Not determined576297205110297366Mouse
1301829Thyls2_mthymic lymphoma susceptibility 2 (mouse)Not determined576297205110297366Mouse
1301713Dbsty2_mdiabesity 2 (mouse)Not determined576297205110297366Mouse
13464249Ahl16_mage related hearing loss, early onset 16 (mouse)576297205110297366Mouse
10401246Bglu13_mblood glucose level 13 (mouse)Not determined579391781113391927Mouse
10755524Mono1_mmonocyte differential 1 (mouse)580701400114701400Mouse
1301419Cypr3_mcytokine production 3 (mouse)Not determined580871790114871944Mouse
10401245Bglu18_mblood glucose level 18 (mouse)Not determined582690609116690738Mouse
13464242Ahl17_mage related hearing loss, early onset 17 (mouse)582690609116690738Mouse
1300801Drb2_mdopamine receptor binding 2 (mouse)Not determined587239005121239199Mouse
1301399Cpfd3_mcerebellum pattern fissures (mouse)Not determined587239005121239199Mouse
1301126Bwem1_mbody weight day 30 males 1 (mouse)Not determined587239005121239199Mouse
10043958Chldq12_mcholesterol and HDL QTL 12 (mouse)Not determined587239005121239199Mouse
13464241Ahl18_mage related hearing loss, early onset 18 (mouse)587239005121239199Mouse
1357725Eae39_mexperimental allergic encephalomyelitis 39 (mouse)Not determined589271017118725963Mouse
1300968Skts4_mskin tumor susceptibility 4 (mouse)Not determined589271017124100176Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589271017146851125Mouse
11049562Lmr24f_mleishmaniasis resistance 24f (mouse)590173096124173175Mouse
1301457Cfsw2_mcystic fibrosis survival to weaning 2 (mouse)Not determined590413140124413285Mouse
1300993Hycdc_mhypercapnic duty cycle (mouse)Not determined590413140124413285Mouse
9587780Afw16_mabdominal fat weight QTL 16 (mouse)Not determined592682300126682419Mouse
1301974Chab7_mcholesterol absorption 7 (mouse)Not determined595085348129085464Mouse
1357644Egrd1_mearly growth rate, direct effect 1 (mouse)Not determined595286714129286920Mouse
1558774Lith17_mlithogenic gene 17 (mouse)Not determined595317683129317856Mouse
10402486Dipa1_mdrug induced psychomotor activation 1 (mouse)Not determined595317683129317856Mouse
13464244Ahl19_mage related hearing loss, early onset 19 (mouse)595317683129317856Mouse
1300940Actd3_mactivity-distance traveled 3 (mouse)Not determined596172519130172667Mouse
1300659Pcd8ts1_mp-glycoprotein positive CD8 T cell subset 1 (mouse)Not determined596883692130883925Mouse
1301858Smdq1_msegregation of mitochondrial DNA QTL 1 (mouse)Not determined596883692130883925Mouse
10045978Tir10_mtrypanosome infection response 10 (mouse)Not determined597871790113883925Mouse
1301042Elmaz1_melevated maze behavior 1 (mouse)Not determined597871790116738565Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:195
Count of miRNA genes:171
Interacting mature miRNAs:181
Transcripts:ENSMUST00000031278
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000031278   ⟹   ENSMUSP00000031278
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl598,854,439 - 98,884,396 (+)Ensembl
RefSeq Acc Id: ENSMUST00000197143   ⟹   ENSMUSP00000142662
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl598,854,415 - 98,873,760 (+)Ensembl
RefSeq Acc Id: ENSMUST00000200388   ⟹   ENSMUSP00000142907
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl598,854,451 - 98,884,396 (+)Ensembl
RefSeq Acc Id: NM_001310677   ⟹   NP_001297606
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39599,002,274 - 99,031,912 (+)NCBI
GRCm38598,854,415 - 98,884,053 (+)NCBI
Sequence:
RefSeq Acc Id: NM_173404   ⟹   NP_775580
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39599,002,274 - 99,031,912 (+)NCBI
GRCm38598,854,415 - 98,884,053 (+)NCBI
MGSCv37599,283,458 - 99,309,979 (+)RGD
Celera596,176,773 - 96,203,304 (+)RGD
cM Map5 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_775580   ⟸   NM_173404
- Peptide Label: isoform 2 preproprotein
- UniProtKB: Q8BHE5 (UniProtKB/Swiss-Prot),   Q149J9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001297606   ⟸   NM_001310677
- Peptide Label: isoform 1 precursor
- UniProtKB: A0A0G2JEU2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000142662   ⟸   ENSMUST00000197143
RefSeq Acc Id: ENSMUSP00000031278   ⟸   ENSMUST00000031278
RefSeq Acc Id: ENSMUSP00000142907   ⟸   ENSMUST00000200388

Promoters
RGD ID:6887250
Promoter ID:EPDNEW_M7076
Type:initiation region
Name:Bmp3_1
Description:Mus musculus bone morphogenetic protein 3 , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38598,854,451 - 98,854,511EPDNEW
RGD ID:6837174
Promoter ID:MM_KWN:43028
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:NM_173404,   UC008YGG.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36599,283,756 - 99,284,307 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88179 AgrOrtholog
Ensembl Genes ENSMUSG00000029335 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000031278 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000142662 UniProtKB/TrEMBL
  ENSMUSP00000142907 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000031278 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000197143 UniProtKB/TrEMBL
  ENSMUST00000200388 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BMP3/BMP3B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cystine-knot_cytokine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-b_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-beta-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFb_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:110075 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:88179 ENTREZGENE
NCBI Gene 110075 ENTREZGENE
PANTHER PTHR11848 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TGF_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Bmp3 PhenoGen
PIRSF BMP3/GDF10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TGF_BETA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF_BETA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TGFB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JE75_MOUSE UniProtKB/TrEMBL
  A0A0G2JEU2 ENTREZGENE, UniProtKB/TrEMBL
  BMP3_MOUSE UniProtKB/Swiss-Prot
  Q149J9 ENTREZGENE, UniProtKB/TrEMBL
  Q8BHE5 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-21 Bmp3  bone morphogenetic protein 3  D630004D15Rik  RIKEN cDNA D630004D15 gene  Data Merged 737654 PROVISIONAL